Affinage

KIFC1

Kinesin-like protein KIFC1 · UniProt Q9BW19

Length
673 aa
Mass
73.7 kDa
Annotated
2026-06-10
100 papers in source corpus 37 papers cited in narrative 37 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 8/8 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

KIFC1 (HSET) is a minus-end-directed, non-processive kinesin-14 motor that cross-links and slides antiparallel microtubules to organize bipolar spindle architecture and broader microtubule arrays (PMID:10525540, PMID:11382767). Single-molecule force spectroscopy shows each homodimer produces a single load-dependent power stroke (~30 nm, ~0.5 pN), with motors cooperating in teams to generate forces ≥1 pN and faster microtubule sliding, establishing that cooperative ensemble behavior underlies its cellular roles (PMID:39095439). During spindle assembly, KIFC1 opposes the plus-end motor Eg5 to balance forces, and its microtubule-sliding activity—not cross-linking alone—sets spindle length, with activity gated by Ran/importin α/β sequestration in the interphase nucleus (PMID:10525540, PMID:19116309). The motor and tail domains are functionally separable: the tail mediates static microtubule cross-linking while the motor domain executes ATP-dependent sliding, a duality that organizes axonal microtubules and steers neuronal migration by providing traction for dynein-driven forces and enabling asymmetric soma tilting (PMID:30804089, PMID:35046122). In cancer cells with supernumerary centrosomes, KIFC1 drives clustering of extra centrosomes into pseudo-bipolar spindles via a CEP215–HSET complex and cooperation with IFT proteins, a function selectively required by amplified-centrosome cells and exploitable by specific small-molecule inhibitors (AZ82, CW069, SR31527) that cause centrosome declustering and multipolar mitosis without harming normal diploid cells (PMID:26987684, PMID:32270908, PMID:23895133, PMID:24210220, PMID:26846349). KIFC1 stability and activity are post-translationally controlled: ATM/ATR phosphorylate Ser26 under DNA damage to enhance centrosome clustering and drug resistance, while the deubiquitinase OTUD6B prevents premature mitotic degradation (PMID:33397932, PMID:39789388). Beyond mitosis, KIFC1 contributes to early endosome fission with Kif5B, Golgi positioning, ciliary membrane-protein export through ASAP1, ER quality-control targeting of misfolded CFTR, intracellular DNA transport, and spermatid acrosome biogenesis (PMID:17360972, PMID:28430595, PMID:29042452, PMID:30066085, PMID:23543461, PMID:12826589). KIFC1 is recurrently overexpressed in cancers, where it is transcriptionally driven by factors including ELK1, TCF-4, and FOXD1 and acts through downstream signaling axes (gankyrin/AKT/TWIST1, HMGA1, TRIM37/PLK4) to promote proliferation, EMT, and chromosomal instability (PMID:31340839, PMID:30115976, PMID:39349439, PMID:37339943, PMID:39541848).

Mechanistic history

Synthesis pass · year-by-year structured walk · 20 steps
  1. 1999 High

    Established that KIFC1/HSET is a spindle-associated microtubule cross-linker whose force opposes Eg5, answering whether it actively shapes spindle architecture.

    Evidence Immuno-EM, inhibitory-antibody microinjection in oocytes, and in vitro aster assembly with simultaneous HSET/Eg5 inhibition

    PMID:10525540

    Open questions at the time
    • Did not resolve motor directionality or biophysical force output
    • No role demonstrated in centrosome-containing mitotic spindle architecture
  2. 2001 High

    Defined HSET biochemically as an active minus-end-directed motor, converting the cross-linker concept into a measured motility activity.

    Evidence Native protein purification from mitotic HeLa cells and in vitro microtubule gliding assay

    PMID:11382767

    Open questions at the time
    • Non-processive behavior and force per motor not quantified
    • Regulation of motor activity in cells not addressed
  3. 2003 Medium

    Linked KIFC1 to nuclear transport machinery and spermatid acrosome biogenesis, broadening its role beyond the spindle.

    Evidence Co-IP of KIFC1 with importin beta and immunofluorescence in rat spermatids

    PMID:12826589

    Open questions at the time
    • Single Co-IP without reciprocal validation
    • Direct cargo carried during acrosome formation not identified
  4. 2004 Medium

    Mapped tail-domain sequences that route KIFC1 to organelles versus the spindle, showing localization is encoded by short divergent tail segments.

    Evidence GFP-fusion tail-deletion constructs with fluorescence localization mapping

    PMID:15236353

    Open questions at the time
    • Binding partners recognized by the targeting sequences not identified
    • Functional consequence of organelle targeting untested
  5. 2007 High

    Showed KIFC1 cooperates with the plus-end motor Kif5B to drive early endosome fission, extending its mechanics to vesicle trafficking.

    Evidence In vitro vesicle motility, antibody inhibition, and FLAG-Kifc1 Co-IP of Kif5B from 293T cells

    PMID:17360972

    Open questions at the time
    • Direct vs. adaptor-mediated KIFC1-Kif5B coupling not resolved
    • Vesicle adaptor linking motor to endosome unknown
  6. 2008 High

    Demonstrated that sliding activity (not cross-linking alone) sets spindle length and that Ran/importin sequesters HSET in the interphase nucleus, defining its spatial regulation.

    Evidence NLS mutagenesis, RNAi, and ATPase-uncoupled motor mutant with quantitative spindle-length readouts in HeLa cells

    PMID:19116309

    Open questions at the time
    • Importin binding sites on HSET not mapped
    • How nuclear release is timed at mitotic entry not detailed
  7. 2013 High

    Identified KIFC1 as the mechanistic driver of centrosome clustering in cancer cells with supernumerary centrosomes, validated by specific small-molecule inhibitors and loss-of-function in diploid cells.

    Evidence ATPase inhibitor characterization (AZ82, CW069) with kinetic mode analysis and centrosome declustering/multipolar assays; shRNA in IMR-90 fibroblasts with Mad2 epistasis

    PMID:23318213 PMID:23895133 PMID:24210220

    Open questions at the time
    • Molecular partners mediating clustering at centrosomes not yet defined in these studies
    • Selectivity basis for cancer vs. normal cells unexplained
  8. 2013 Medium

    Revealed an unexpected activity: KIFC1 actively transports bare double-stranded DNA along microtubules.

    Evidence Single-molecule in-cell imaging, mass spectrometry of DNA-bound proteins, and extract immunodepletion motility assays

    PMID:23543461

    Open questions at the time
    • Physiological context and cargo specificity of DNA transport unclear
    • Direct vs. adaptor-mediated DNA binding not resolved
  9. 2016 High

    Defined the CEP215-HSET complex as the physical bridge linking centrosomes to spindle poles and mediating clustering of extra centrosomes.

    Evidence Proteomic interaction profiling, CEP215 HSET-binding-domain deletion, and centrosome phenotype imaging including patient-derived cells

    PMID:26987684

    Open questions at the time
    • Structural basis of CEP215-HSET binding not determined
    • Whether SR31527/CEP215 act in the same pathway not directly tested
  10. 2016 High

    Provided direct-binding and structural evidence for an allosteric inhibitor site on KIFC1, supporting it as a druggable anticancer target.

    Evidence Bio-layer interferometry, ATPase inhibition, STD-NMR and docking, and centrosome clustering assay in TNBC cells (SR31527)

    PMID:26846349

    Open questions at the time
    • Co-crystal structure of inhibitor bound to KIFC1 absent
    • In vivo efficacy and selectivity not established here
  11. 2017 Medium

    Extended KIFC1's cross-linking role to organelle positioning, showing it tethers the Golgi to microtubules.

    Evidence KIFC1 domain-deletion constructs with Golgi morphology and co-localization readouts

    PMID:28430595

    Open questions at the time
    • Golgi receptor recognized by the motor domain unknown
    • Single-lab localization-based model without biochemical reconstitution
  12. 2018 Medium

    Connected KIFC1 to ciliogenesis through Golgi export of ciliary membrane proteins and an ASAP1 interaction, plus a role in ER quality control of misfolded CFTR.

    Evidence KIFC1 knockdown with ciliary-receptor trafficking and ciliogenesis assays, KIFC1-ASAP1 Co-IP; LC-MS/MS interaction profiling with F508del-CFTR and stability assays

    PMID:29042452 PMID:30066085

    Open questions at the time
    • Whether KIFC1 transports CFTR or merely associates is unresolved
    • Directness of ASAP1 interaction and shared adaptors not detailed
  13. 2019 High

    Established KIFC1 as an organizer of axonal microtubules and a regulator of S-phase/chromatin maintenance, separating its ATP-dependent sliding from ATP-independent cross-linking.

    Evidence RNAi, pharmacological inhibition, and mutant constructs in rat neurons; kifc1-/- human cells with cell-cycle, lamin, and spindle readouts

    PMID:30804089 PMID:31127080

    Open questions at the time
    • Replication-related cargos transported during S phase not identified
    • Mechanism of lamin degradation upon KIFC1 loss unclear
  14. 2019 Medium

    Identified KIFC1 as a transcriptional co-activator of HMGA1 driven downstream of TCF-4, linking its overexpression to cancer gene programs.

    Evidence KIFC1-HMGA1 Co-IP, ChIP, and dual-luciferase reporter assays in HCC cells

    PMID:31340839

    Open questions at the time
    • How a microtubule motor enters the nucleus to co-activate transcription unexplained
    • Direct DNA or chromatin engagement by KIFC1 not shown
  15. 2020 High

    Showed IFT proteins directly cooperate with HSET for efficient centrosome clustering, integrating ciliary trafficking machinery into the clustering mechanism.

    Evidence siRNA and AID-inducible IFT88 degradation combined with HSET inhibition and live imaging

    PMID:32270908

    Open questions at the time
    • Mechanistic step at which IFT proteins act during clustering not defined
    • Whether IFT-HSET complex is the same as CEP215-HSET complex untested
  16. 2021 High

    Defined ATM/ATR phosphorylation of KIFC1 at Ser26 as a DNA-damage-induced switch that maintains centrosome clustering and promotes drug resistance.

    Evidence In vivo phosphorylation assay, Ser26 mutagenesis, ATM/ATR inhibition, clustering and tumor-recurrence models

    PMID:33397932

    Open questions at the time
    • How Ser26 phosphorylation alters motor mechanics or partner binding unresolved
    • Phosphatase reversing this mark unidentified
  17. 2022 High

    Established KIFC1 as essential for oocyte meiotic spindle and migration, acting through tubulin acetylation regulators and actin-nucleation machinery, and as a steering factor in neuronal migration.

    Evidence KIFC1 depletion with mRNA rescue, MS interaction screens, and imaging of tubulin acetylation/actin in oocytes; RNAi and sliding-vs-crosslinking mutants in vitro and in mouse brain

    PMID:35046122 PMID:35142352

    Open questions at the time
    • Mechanism coupling KIFC1 to HDAC6/NAT10 and actin factors not biochemically resolved
    • How crosslinking provides traction for dynein not directly visualized
  18. 2024 High

    Quantified the biophysical basis of KIFC1 function: non-processive single power strokes per encounter with cooperative force amplification by motor teams.

    Evidence Single-molecule optical-trap force spectroscopy and in vitro multi-motor MT-sliding assays

    PMID:39095439

    Open questions at the time
    • Stoichiometry of cooperative teams in vivo unknown
    • How post-translational marks modulate force output untested
  19. 2024 Medium

    Expanded the cancer post-translational and signaling network of KIFC1, including CDK1 phosphorylation, TRIM37/PLK4 centrosome amplification, deubiquitinase stabilization, and multiple RNA/transcription axes.

    Evidence Co-IP, ubiquitination assays, epistasis rescue, and transcription-factor ChIP/luciferase across endometrial, cervical, pancreatic, sarcoma, bladder, and breast cancer models (CDK1, TRIM37/PLK4, USP25, FXR1/MAD2L1, ELK1, FOXD1, BUB1B, MYH9)

    PMID:37339943 PMID:38456590 PMID:38902769 PMID:39349439 PMID:39387242 PMID:39541848 PMID:40379626 PMID:40857057

    Open questions at the time
    • Several interactions rest on single Co-IPs without reciprocal validation
    • Direct kinase assays for CDK1-KIFC1 phosphorylation not described
    • Mechanistic unification of these context-specific axes incomplete
  20. 2025 High

    Defined OTUD6B as a deubiquitinase that protects KIFC1 from premature mitotic degradation, identifying a stability control independent of centrosome amplification.

    Evidence DUB siRNA screen, OTUD6B-KIFC1 Co-IP, polyubiquitination assay, catalytic-dead and overexpression rescues, and CRISPR OTUD6B knockout

    PMID:39789388

    Open questions at the time
    • E3 ligase opposing OTUD6B on KIFC1 not identified
    • Mitotic timing signal triggering KIFC1 deubiquitination unknown

Open questions

Synthesis pass · forward-looking unresolved questions
  • How KIFC1's distinct activities—spindle/centrosome mechanics, organelle and vesicle positioning, DNA/cargo transport, and nuclear transcriptional co-activation—are partitioned and coordinated by its post-translational marks and tail-domain partners remains unresolved.
  • No unified model linking specific PTMs/partners to each functional mode
  • Structural basis for cargo selection by motor vs. tail domain not determined
  • How a cytoskeletal motor exerts nuclear transcriptional functions mechanistically unexplained

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0003774 cytoskeletal motor activity 4 GO:0008092 cytoskeletal protein binding 4 GO:0140657 ATP-dependent activity 4 GO:0003677 DNA binding 1
Localization
GO:0005815 microtubule organizing center 3 GO:0005634 nucleus 2 GO:0005794 Golgi apparatus 2 GO:0005856 cytoskeleton 2
Pathway
R-HSA-1640170 Cell Cycle 3 R-HSA-1266738 Developmental Biology 2 R-HSA-1643685 Disease 2 R-HSA-5653656 Vesicle-mediated transport 2
Partners
ASAP1CEP215FXR1HMGA1KIF5BKPNA2OTUD6BTRIM37
Complex memberships
CEP215-HSET complex

Evidence

Reading pass · 37 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1999 HSET (KIFC1) localizes between microtubules within the mammalian metaphase spindle (immuno-EM), consistent with a microtubule cross-linking function. Microinjection of inhibitory antibodies showed HSET activity is essential for meiotic spindle organization in murine oocytes and taxol-induced aster assembly in cultured cells. In vitro, simultaneous inhibition of HSET and Eg5 restores aster organization, demonstrating that HSET and Eg5 exert opposing forces during spindle assembly. HSET inhibition alone did not affect mitotic spindle architecture in centrosome-containing cultured cells. Immuno-EM, antibody microinjection, in vitro aster assembly assay, simultaneous inhibition of HSET and Eg5 The Journal of cell biology High 10525540
2001 Native HSET purified from mitotic HeLa cells migrates as a ~75 kDa protein and is an active minus-end-directed motor that induces microtubule gliding at ~5 µm/min, with microtubules gliding an average of 3 µm before ceasing movement. Native protein purification from mitotic HeLa cells, in vitro microtubule gliding assay The Journal of biological chemistry High 11382767
2003 KIFC1 associates with importin beta and co-localizes with it on curvilinear structures associated with spermatid nuclei; KIFC1 localizes sequentially to membrane-bounded organelles, then the acrosomal vesicle, and finally the elongating acrosome during spermatogenesis, suggesting a role in acrosome formation and/or elongation via nuclear transport factor interactions. Co-immunoprecipitation (KIFC1 with importin beta), immunofluorescence localization in rat spermatids Biology of reproduction Medium 12826589
2004 The divergent tail domains of KIFC1 and KIFC5A determine their distinct subcellular localizations: a 19 amino acid sequence in the KIFC1 tail is sufficient to target KIFC1 to membrane-bounded organelles, whereas the KIFC5A tail contains a 43 amino acid sequence directing it to the spindle. GFP-fusion constructs with tail deletions transfected into cells; fluorescence microscopy to map localization determinants Cell motility and the cytoskeleton Medium 15236353
2007 Kifc1 and Kif5B mediate minus-end and plus-end motility, respectively, of early endocytic vesicles in mouse liver. More than 90% of Kifc1-associated vesicles also contained Kif5B. Inhibition of either motor reduced vesicle fission, indicating that opposing forces from both motors are required for fission. FLAG-Kifc1 immunoprecipitated native Kif5B from 293T cells, showing the two motors can interact. In vitro vesicle motility on microtubules, antibody inhibition, co-immunoprecipitation (FLAG-Kifc1 pulldown of Kif5B) Molecular biology of the cell High 17360972
2008 Mutation of the nuclear localization signal (NLS) of HSET causes cytoplasmic accumulation and strong microtubule bundling. HSET overexpression in HeLa cells results in longer spindles, while RNAi knockdown results in shorter spindles without affecting pole formation. An HSET mutant with sliding activity uncoupled from ATPase activity produced shorter spindles than wild-type HSET overexpression, demonstrating that microtubule sliding (not just cross-linking) controls spindle length. Ran/importin alpha/beta regulate HSET by sequestering it in the nucleus during interphase. NLS mutagenesis, RNAi knockdown, ATPase-uncoupled motor mutant overexpression, spindle length measurement in HeLa cells Molecular biology of the cell High 19116309
2013 KIFC1 actively transports bare double-stranded DNA along microtubules. Mass spectrometry of DNA-bound proteins identified KIFC1 as a preferential binder of short DNA molecules. Cell-extract depletion of KIFC1 significantly decreased intracellular DNA motion, confirming active involvement of KIFC1 in intracellular DNA transport. Single-molecule in-cell imaging, in vitro motility assay with cell extracts, mass spectrometry of DNA-bound proteins, extract immunodepletion Nucleic acids research Medium 23543461
2013 AZ82, the first reported small molecule inhibitor of KIFC1, binds specifically to the KIFC1/microtubule binary complex and inhibits MT-stimulated KIFC1 ATPase activity in an ATP-competitive, MT-noncompetitive manner (Ki = 0.043 µM). AZ82 engages with KIFC1 inside cells to reverse monopolar spindles induced by Eg5 inhibition, and causes centrosome declustering in BT-549 breast cancer cells with amplified centrosomes. Biochemical ATPase assay, kinetic inhibition mode analysis, cell-based spindle assay, centrosome declustering assay ACS chemical biology High 23895133
2013 CW069, an allosteric inhibitor of HSET, inhibits HSET ATPase activity in vitro and induces multipolar mitoses selectively in cancer cells containing supernumerary centrosomes, but not in normal cells with two centrosomes, establishing HSET as the mechanistic driver of centrosome clustering in those cancer cells. In vitro HSET ATPase inhibition assay, cell-based multipolar mitosis phenotype scoring, in silico compound design followed by biochemical validation Chemistry & biology High 24210220
2013 KIFC1 knockdown in normal diploid human primary fibroblasts (IMR-90) induces multiple MTOCs, lagging chromosomes, micronuclei, and aneuploidy, ultimately leading to cellular senescence. Double knockdown of KIFC1 and Mad2 causes apoptosis rather than senescence, placing KIFC1 in a pathway distinct from the spindle assembly checkpoint (Mad2 pathway) for bipolar MTOC formation. Lentiviral shRNA knockdown, karyotyping, senescence-associated beta-galactosidase staining, double knockdown epistasis with Mad2 Cell structure and function Medium 23318213
2016 A CEP215-HSET complex physically links centrosomes with spindle poles. HSET was identified as a direct binding partner of CEP215 by proteomic profiling. Targeted deletion of the HSET-binding domain of CEP215 causes centrosome detachment and HSET depletion at centrosomes. In cancer cells with centrosome amplification, the CEP215-HSET complex promotes clustering of extra centrosomes into pseudo-bipolar spindles. Proteomic profiling (MS-based interaction screen), targeted domain deletion in vertebrate cells, immunofluorescence of centrosome phenotypes Nature communications High 26987684
2016 SR31527, a small molecule inhibitor, binds directly to KIFC1 (Kd = 25.4 nM by bio-layer interferometry) and inhibits MT-stimulated KIFC1 ATPase activity (IC50 = 6.6 µM). STD-NMR and computational modeling indicate SR31527 binds to an allosteric site on KIFC1 distinct from the ATP-binding site. SR31527 prevents centrosome clustering in triple-negative breast cancer cells. Bio-layer interferometry (direct binding), ATPase inhibition assay, STD-NMR, computational docking, centrosome clustering cell assay The Biochemical journal High 26846349
2017 KIFC1 regulates the positioning and structural integrity of the Golgi apparatus in non-polarized mammalian cells. The motor domain of KIFC1 mediates recognition and binding of the Golgi, while the tail domain statically cross-links to microtubules, suggesting KIFC1 functions as a cross-linker between the Golgi and microtubules to maintain central Golgi positioning. KIFC1 domain-deletion constructs, immunofluorescence of Golgi morphology, co-localization studies in mammalian cells Oncotarget Medium 28430595
2018 KIFC1 is required for export of ciliary membrane proteins from the Golgi complex in non-photoreceptor cells. After serum starvation, KIFC1 immunoreactivity appears in the Golgi region. KIFC1 knockdown inhibits export of ciliary receptors from the Golgi. KIFC1 physically interacts with ASAP1 (an ARF-GAP that regulates budding of rhodopsin transport carriers). KIFC1 depletion causes Golgi accumulation of ASAP1 and reduces centrosomal levels of IFT20 and TTBK2, impairing ciliogenesis. KIFC1 knockdown, co-immunoprecipitation (KIFC1-ASAP1 interaction), immunofluorescence of ciliary receptor trafficking, ciliogenesis assay FASEB journal Medium 29042452
2018 KIFC1 was identified as a stronger interactor with misfolded F508del-CFTR (bearing ER retention motifs) versus F508del-CFTR lacking these motifs, by LC-MS/MS proteomic interaction profiling. Decreasing KIFC1 levels or activity stabilizes the immature form of F508del-CFTR by reducing its degradation, implicating KIFC1 in early ER quality control targeting of misfolded CFTR. LC-MS/MS proteomic interaction profiling, KIFC1 siRNA knockdown and pharmacological inhibition, CFTR stability/degradation assays Cellular and molecular life sciences Medium 30066085
2018 KIFC1 promotes hepatocellular carcinoma EMT and metastasis via gankyrin/AKT/TWIST1 signaling. KIFC1 knockdown inhibits gankyrin-dependent AKT activation; inhibiting gankyrin reverses the EMT induced by KIFC1. miR-532-3p directly regulates KIFC1 expression. KIFC1 knockdown/overexpression in HCC cell lines and in vivo xenograft, luciferase reporter for miR-532-3p targeting, pathway inhibition epistasis Oncogene Medium 30115976
2019 KIFC1 interacts with HMGA1, an architectural transcription factor, and enhances HMGA1 transcriptional activity. HMGA1 binds to the promoters of Stat3, MMP2, and EMT-related genes to promote transcription. The upstream transcription factor TCF-4 activates KIFC1 expression. These interactions were demonstrated by co-immunoprecipitation, ChIP, and dual-luciferase reporter assays. Co-immunoprecipitation (KIFC1-HMGA1), ChIP assay, dual-luciferase reporter assay, KIFC1 knockdown in HCC cells Journal of experimental & clinical cancer research Medium 31340839
2019 KIFC1 participates in DNA synthesis regulation during S phase and chromatin maintenance during mitosis. KIFC1 deletion prolongs S phase, causes aberrant nuclear membrane morphology with degradation of lamin B and lamin A/C, disrupts metaphase spindle assembly, and leads to micronuclei and aneuploidy. KIFC1 may transport replication-related proteins into the nucleus to facilitate S phase progression. KIFC1 knockout in human cells (kifc1-/-), cell cycle kinetics analysis, nuclear membrane/lamin immunostaining, spindle assembly assay Cell death & disease Medium 31127080
2019 KIFC1 is an organizer of microtubules in axons of postmitotic neurons. Partial RNAi depletion, pharmacological inhibition, and expression of mutant KIFC1 constructs demonstrate that KIFC1 slides microtubules in an ATP-dependent manner and cross-links them in an ATP-independent manner to oppose subsequent sliding by other motors, regulating axonal growth, retraction, and growth cone morphology. RNAi in rat neurons, KIFC1 pharmacological inhibitors, mutant KIFC1 construct expression, live imaging of microtubule organization and axon morphology The Journal of neuroscience High 30804089
2020 IFT proteins (including IFT88) directly interact with HSET (KIFC1) and are required together with HSET for efficient centrosome clustering in cancer cells with supernumerary centrosomes. siRNA knockdown of IFT proteins or AID-inducible degradation of IFT88 combined with HSET inhibition impairs clustering dynamics. siRNA knockdown of IFT proteins, AID-inducible IFT88 degradation, small-molecule HSET inhibition, direct interaction assay, live imaging of centrosome clustering EMBO reports High 32270908
2020 TRIM8 interacts with KIFC1 and KIF11/Eg5 in mouse embryonic neural stem cells (identified by proteomics). TRIM8 localizes to the mitotic spindle during mitosis and plays a role in centrosome separation at the beginning of mitosis, with downstream impact on chromosomal stability. Proteomic interaction screen (TRIM8 interactome by MS), immunofluorescence of TRIM8 at mitotic spindle, centrosome separation assay Cancer letters Medium 31904480
2021 ATM and ATR kinases phosphorylate KIFC1 at Ser26 under DNA damaging conditions. This phosphorylation selectively maintains centrosome clustering in cancer cells with amplified centrosomes, promoting drug resistance and tumor recurrence. Inhibition of KIFC1 phosphorylation at Ser26 represses centrosome clustering. In vivo phosphorylation assay, phosphorylation-site mutagenesis (Ser26), ATM/ATR inhibition, centrosome clustering assay, tumor recurrence models Nature communications High 33397932
2022 KIFC1 depletion in mouse oocytes causes failure of polar body extrusion, disrupted meiotic spindle formation, and chromosome misalignment. KIFC1 affects tubulin acetylation via HDAC6 and NAT10. Mass spectrometry showed KIFC1 associates with actin nucleation factors; KIFC1 depletion causes aberrant distribution of actin filaments, abnormal formin 2 and ARP2/3 complex expression, and disrupted endoplasmic reticulum distribution, impairing actin-dependent spindle migration. KIFC1 depletion (morpholino/siRNA), mass spectrometry interaction screen, rescue by exogenous KIFC1 mRNA, immunofluorescence of tubulin acetylation and actin distribution Development (Cambridge, England) High 35142352
2022 KIFC1 regulates the trajectory of neuronal migration. Depletion of KIFC1 causes neurons to migrate off their appropriate path. KIFC1 cross-linking of microtubules into a non-sliding mode is necessary for dynein-driven forces to achieve sufficient traction to thrust the soma forward. Asymmetric KIFC1-driven microtubule sliding enables soma tilting for midcourse trajectory corrections. KIFC1 also contributes to interkinetic nuclear migration during earlier neuronal development. RNAi in rat migratory neurons in vitro, in vivo mouse brain electroporation, ectopic expression of mutant KIFC1 forms (sliding vs. cross-linking mutants) The Journal of neuroscience High 35046122
2024 HSET (KIFC1) and KlpA are non-processive kinesin-14 motors that produce single load-dependent power strokes (~30 nm for HSET) per microtubule encounter. Each homodimer generates ~0.5 pN force. When assembled in teams, multiple motors cooperate to generate forces ≥1 pN and exhibit increased MT-sliding velocities, demonstrating cooperative behavior is essential for their cellular functions. Single-molecule optical trap force measurements, in vitro MT-sliding assays with multiple motor assemblies Nature communications High 39095439
2023 HSET (KIFC1) and KlpA are non-processive microtubule motors that function under load with single power strokes per MT encounter (~30-35 nm), generating ~0.5 pN per homodimer; cooperative team activity increases both force and MT-sliding velocity. Single-molecule optical trap force spectroscopy, in vitro MT-sliding assays bioRxivpreprint Medium 37333225
2025 OTUD6B deubiquitinase interacts with KIFC1 and prevents its polyubiquitination and premature degradation during mitosis. In OTUD6B-deficient cells, KIFC1 is prematurely degraded, leading to increased multipolar spindles without centrosome amplification. Phenotypic rescue depends on OTUD6B catalytic activity and is recapitulated by KIFC1 overexpression, establishing OTUD6B as a writer/eraser controlling KIFC1 stability via ubiquitination. Parallel siRNA screens of deubiquitinases, co-immunoprecipitation (OTUD6B-KIFC1), polyubiquitination assay, catalytic-dead OTUD6B mutant rescue, KIFC1 overexpression rescue, CRISPR-Cas9 OTUD6B knockout EMBO reports High 39789388
2024 CDK1 directly phosphorylates KIFC1 in endometrial carcinoma cells (shown by Co-IP of CDK1 and KIFC1, and detection of phosphorylated KIFC1). CDK1-mediated KIFC1 phosphorylation activates the PI3K/AKT pathway to promote tumor proliferation and invasion. Co-immunoprecipitation (CDK1-KIFC1 interaction), western blot for phospho-KIFC1, PI3K/AKT pathway activation assay, CDK1 knockdown in vivo and in vitro Journal of gynecologic oncology Medium 38456590
2024 KIFC1 inhibits the E3 ubiquitin ligase TRIM37, thereby preventing ubiquitination and degradation of PLK4, which promotes centrosome amplification and endometrial cancer progression. KIFC1 overexpression increases centrosome number and chromosomal instability; this depends on KIFC1's regulation of TRIM37-PLK4 axis. KIFC1/TRIM37 knockdown and overexpression, PLK4 ubiquitination assay, centrosome number quantification, in vivo xenograft model Cell death discovery Medium 39349439
2024 USP25, a deubiquitinating enzyme, stabilizes KIFC1 protein through deubiquitination, promoting its accumulation in cervical cancer cells. USP25 suppression decreases KIFC1 and MYCBP levels; reintroduction of KIFC1 into USP25-deficient cells restores MYCBP expression, placing USP25 upstream of KIFC1 in a USP25/KIFC1/MYCBP signaling axis. USP25 and KIFC1 knockdown/overexpression, ubiquitination assay, epistasis rescue experiments (KIFC1 re-expression in USP25-KD cells), in vivo xenograft Cell death & disease Medium 40379626
2024 KIFC1 interacts with KPNA2 (karyopherin alpha 2) in bladder cancer cells (co-immunoprecipitation). The KPNA2-KIFC1 interaction facilitates G2/M phase transition and promotes tumor progression via PI3K/AKT pathway activation. Co-immunoprecipitation (KPNA2-KIFC1), cell cycle analysis, PI3K/AKT pathway assay Cellular & molecular biology letters Low 39956902
2024 ELK1 binds to the KIFC1 promoter and activates KIFC1 transcription in breast cancer cells (validated by dual-luciferase reporter assay and ChIP). KIFC1 overexpression increases intracellular GSH levels, reduces ROS, and promotes proliferation; GSH synthesis inhibitor (BSO) attenuates this proliferative effect, linking KIFC1 to glutathione metabolism regulation. ChIP assay, dual-luciferase reporter, GSH/GSSG measurement, ROS assay, BSO rescue experiment The journal of obstetrics and gynaecology research Medium 37339943
2024 KIFC1 binds to and stabilizes BUB1B by competing with ubiquitination, reducing BUB1B degradation in pancreatic cancer cells. Rescue experiments showed that BUB1B overexpression reverses the growth inhibition caused by KIFC1 knockdown, placing BUB1B downstream of KIFC1. Co-immunoprecipitation (KIFC1-BUB1B), ubiquitination assay, epistasis rescue (BUB1B overexpression in KIFC1-KD cells), in vivo xenograft Journal of cellular and molecular medicine Medium 40857057
2024 KIFC1 interacts with Aurora B kinase (identified by proteomics in ESCC cells). KIFC1 knockdown reduces Aurora B distribution on the metaphase plate and substantially inhibits phosphorylation of Histone H3 (canonical Aurora B substrate), suggesting KIFC1 transports or positions Aurora B at the kinetochore region. Proteomics (mass spectrometry) to identify KIFC1 binding partners, immunofluorescence of Aurora B, Histone H3 phosphorylation assay after KIFC1 knockdown Aging Low 37955677
2024 KIFC1 interacts with FXR1, an RNA-binding protein, and this interaction stabilizes MAD2L1 mRNA in an m6A-dependent manner. KIFC1 knockout induces cellular senescence in soft tissue sarcoma cells via FXR1-dependent MAD2L1 mRNA regulation. Co-immunoprecipitation (KIFC1-FXR1 interaction), RNA stability assay, m6A-dependent mRNA analysis, KIFC1 KO in vitro and PDX models Advanced science Medium 39387242
2024 FOXD1 binds to the KIFC1 promoter (validated by ChIP and dual-luciferase reporter assays) and activates KIFC1 transcription, promoting aerobic glycolysis and cisplatin resistance in breast cancer cells. Overexpression of FOXD1 reverses the inhibitory effects of KIFC1 knockdown on cisplatin resistance. ChIP assay, dual-luciferase reporter, KIFC1 and FOXD1 knockdown/overexpression, glycolysis measurements (ECAR, glucose, lactate), epistasis rescue Reproductive biology Medium 39541848
2025 In TNBC cells, nuclear KIFC1 interacts with the tumor suppressor MYH9 (myosin heavy chain 9). This interaction is more prominent in African American TNBC-derived cells than European American cells. KIFC1 KO in AA TNBC cells significantly inhibited proliferation, migration, and invasion, with RNA sequencing showing downregulation of migration/invasion/metastasis genes, but these effects were not seen in EA cells. Co-immunoprecipitation (KIFC1-MYH9), KIFC1 CRISPR-Cas9 knockout, RNA sequencing, pharmacological inhibition Cell communication and signaling Medium 38902769

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1999 The kinesin-related protein, HSET, opposes the activity of Eg5 and cross-links microtubules in the mammalian mitotic spindle. The Journal of cell biology 275 10525540
2008 Kinesin-14 family proteins HSET/XCTK2 control spindle length by cross-linking and sliding microtubules. Molecular biology of the cell 160 19116309
2003 C-terminal kinesin motor KIFC1 participates in acrosome biogenesis and vesicle transport. Biology of reproduction 114 12826589
2013 Design, synthesis, and biological evaluation of an allosteric inhibitor of HSET that targets cancer cells with supernumerary centrosomes. Chemistry & biology 97 24210220
2013 Discovery and mechanistic study of a small molecule inhibitor for motor protein KIFC1. ACS chemical biology 93 23895133
2012 Acentrosomal spindle organization renders cancer cells dependent on the kinesin HSET. Journal of cell science 92 22946058
2015 KIFC1 is a novel potential therapeutic target for breast cancer. Cancer biology & therapy 83 26177331
2018 KIFC1 regulated by miR-532-3p promotes epithelial-to-mesenchymal transition and metastasis of hepatocellular carcinoma via gankyrin/AKT signaling. Oncogene 77 30115976
2016 A CEP215-HSET complex links centrosomes with spindle poles and drives centrosome clustering in cancer. Nature communications 73 26987684
2016 KIFC1: a promising chemotherapy target for cancer treatment? Oncotarget 65 27102297
2015 HSET overexpression fuels tumor progression via centrosome clustering-independent mechanisms in breast cancer patients. Oncotarget 65 25788277
2021 The ATM and ATR kinases regulate centrosome clustering and tumor recurrence by targeting KIFC1 phosphorylation. Nature communications 60 33397932
2007 Kif5B and Kifc1 interact and are required for motility and fission of early endocytic vesicles in mouse liver. Molecular biology of the cell 58 17360972
2009 KIFC1 participates in acrosomal biogenesis, with discussion of its importance for the perforatorium in the Chinese mitten crab Eriocheir sinensis. Cell and tissue research 52 19484267
2016 A centrosome clustering protein, KIFC1, predicts aggressive disease course in serous ovarian adenocarcinomas. Journal of ovarian research 49 26992853
2019 KIFC1 is activated by TCF-4 and promotes hepatocellular carcinoma pathogenesis by regulating HMGA1 transcriptional activity. Journal of experimental & clinical cancer research : CR 47 31340839
2019 KIFC1 Inhibitor CW069 Induces Apoptosis and Reverses Resistance to Docetaxel in Prostate Cancer. Journal of clinical medicine 46 30744126
2016 KIFC1 induces resistance to docetaxel and is associated with survival of patients with prostate cancer. Urologic oncology 45 27665358
2001 Purification and characterization of native conventional kinesin, HSET, and CENP-E from mitotic hela cells. The Journal of biological chemistry 41 11382767
2016 Discovery of a novel inhibitor of kinesin-like protein KIFC1. The Biochemical journal 40 26846349
2022 Kinesin motor KIFC1 is required for tubulin acetylation and actin-dependent spindle migration in mouse oocyte meiosis. Development (Cambridge, England) 37 35142352
2016 Induction of KIFC1 expression in gastric cancer spheroids. Oncology reports 37 27176706
2013 Kinesin KIFC1 actively transports bare double-stranded DNA. Nucleic acids research 37 23543461
2013 KIFC1 is essential for bipolar spindle formation and genomic stability in the primary human fibroblast IMR-90 cell. Cell structure and function 36 23318213
2014 Discovery of potent KIFC1 inhibitors using a method of integrated high-throughput synthesis and screening. Journal of medicinal chemistry 35 25458601
2019 Kinesin-14 motor protein KIFC1 participates in DNA synthesis and chromatin maintenance. Cell death & disease 33 31127080
2013 Acroframosome-dependent KIFC1 facilitates acrosome formation during spermatogenesis in the caridean shrimp Exopalaemon modestus. PloS one 33 24098763
2010 Molecular cloning and characterization of KIFC1-like kinesin gene (es-KIFC1) in the testis of the Chinese mitten crab Eriocheir sinensis. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 32 20554056
2016 miR-135a acts as a tumor suppressor in gastric cancer in part by targeting KIFC1. OncoTargets and therapy 30 27366092
2020 IFT proteins interact with HSET to promote supernumerary centrosome clustering in mitosis. EMBO reports 29 32270908
2016 Transient endoreplication down-regulates the kinesin-14 HSET and contributes to genomic instability. Molecular biology of the cell 29 27489338
2019 Mitotic Motor KIFC1 Is an Organizer of Microtubules in the Axon. The Journal of neuroscience : the official journal of the Society for Neuroscience 28 30804089
2018 Proteomic interaction profiling reveals KIFC1 as a factor involved in early targeting of F508del-CFTR to degradation. Cellular and molecular life sciences : CMLS 28 30066085
2021 KIFC1 promotes aerobic glycolysis in endometrial cancer cells by regulating the c-myc pathway. Journal of bioenergetics and biomembranes 26 34729671
2004 Comparative analysis of two C-terminal kinesin motor proteins: KIFC1 and KIFC5A. Cell motility and the cytoskeleton 26 15236353
2010 KIFC1-like motor protein associates with the cephalopod manchette and participates in sperm nuclear morphogenesis in Octopus tankahkeei. PloS one 25 21187923
2020 Kinesin Family Member C1 (KIFC1) Regulated by Centrosome Protein E (CENPE) Promotes Proliferation, Migration, and Epithelial-Mesenchymal Transition of Ovarian Cancer. Medical science monitor : international medical journal of experimental and clinical research 24 33361741
2018 Export of membrane proteins from the Golgi complex to the primary cilium requires the kinesin motor, KIFC1. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 24 29042452
2012 Characterization and expression pattern of KIFC1-like kinesin gene in the testis of the Macrobrachium nipponense with discussion of its relationship with structure lamellar complex (LCx) and acroframosome (AFS). Molecular biology reports 24 22327780
2020 TRIM8 interacts with KIF11 and KIFC1 and controls bipolar spindle formation and chromosomal stability. Cancer letters 23 31904480
2017 Minus end-directed kinesin-14 KIFC1 regulates the positioning and architecture of the Golgi apparatus. Oncotarget 23 28430595
2016 Decreased Expression of KIFC1 in Human Testes with Globozoospermic Defects. Genes 22 27690105
2017 KIFC1 and myosin Va: two motors for acrosomal biogenesis and nuclear shaping during spermiogenesis of Portunus trituberculatus. Cell and tissue research 21 28639134
2017 C-terminal kinesin motor KIFC1 participates in facilitating proper cell division of human seminoma. Oncotarget 21 28977870
2020 Inhibition of kinesin motor protein KIFC1 by AZ82 induces multipolar mitosis and apoptosis in prostate cancer cell. Gene 20 32717307
2021 KIFC1 regulates ZWINT to promote tumor progression and spheroid formation in colorectal cancer. Pathology international 18 33819373
2018 Fission yeast cells overproducing HSET/KIFC1 provides a useful tool for identification and evaluation of human kinesin-14 inhibitors. Fungal genetics and biology : FG & B 17 29684553
2020 miR-635 targets KIFC1 to inhibit the progression of gastric cancer. Journal of investigative medicine : the official publication of the American Federation for Clinical Research 16 32753405
2019 C-terminal kinesin motor es-KIFC1 regulates nuclear formation during spermiogenesis in Chinese mitten crab Eriocheir sinensis. Gene 16 31446094
2010 Molecular cloning and characterization of KIFC1-like kinesin gene (ot-kifc1) from Octopus tankahkeei. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 16 20304088
2009 The presence of kinesin superfamily motor proteins KIFC1 and KIF17 in normal and pathological human placenta. Placenta 16 19679349
2022 Computational benchmarking of putative KIFC1 inhibitors. Medicinal research reviews 15 36104980
2019 KIFC1 promotes the proliferation of hepatocellular carcinoma in vitro and in vivo. Oncology letters 15 31788047
2017 The C-terminal kinesin motor KIFC1 may participate in nuclear reshaping and flagellum formation during spermiogenesis of Larimichthys crocea. Fish physiology and biochemistry 15 28534180
2017 Overexpression of KIFC1 and its association with spheroid formation in esophageal squamous cell carcinoma. Pathology, research and practice 14 28964573
2020 Kinesin Family Member C1 (KIFC1) Accelerates Proliferation and Invasion of Endometrial Cancer Cells Through Modulating the PI3K/AKT Signaling Pathway. Technology in cancer research & treatment 13 33034273
2018 Expression and putative functions of KIFC1 for nuclear reshaping and midpiece formation during spermiogenesis of Phascolosoma esculenta. Gene 13 30316921
2017 KIFC1 is essential for acrosome formation and nuclear shaping during spermiogenesis in the lobster Procambarus clarkii. Oncotarget 13 28415605
2022 KIFC1 Regulates the Trajectory of Neuronal Migration. The Journal of neuroscience : the official journal of the Society for Neuroscience 12 35046122
2024 Identification of KIFC1 as a putative vulnerability in lung cancers with centrosome amplification. Cancer gene therapy 11 39179685
2024 KIFC1 depends on TRIM37-mediated ubiquitination of PLK4 to promote centrosome amplification in endometrial cancer. Cell death discovery 11 39349439
2023 ELK1/KIFC1 axis promotes breast cancer cell proliferation by regulating glutathione metabolism. The journal of obstetrics and gynaecology research 11 37339943
2019 KIFC1 is essential for normal spermatogenesis and its depletion results in early germ cell apoptosis in the Kuruma shrimp, Penaeus (Marsupenaeus) japonicus. Aging 11 31895691
2013 The expression pattern of the C-terminal kinesin gene kifc1 during the spermatogenesis of Sepiella maindroni. Gene 11 24035901
2013 Molecular characterization and expression analysis of a KIFC1-like kinesin gene in the testis of Eumeces chinensis. Molecular biology reports 11 24078165
2025 Tumor-derived exosomal KPNA2 activates fibroblasts and interacts with KIFC1 to promote bladder cancer progression, a process inhibited by miR-26b-5p. Cellular & molecular biology letters 10 39956902
2022 Target-based virtual screening, computational multiscoring docking and molecular dynamics simulation of small molecules as promising drug candidate affecting kinesin-like protein KIFC1. Cell biochemistry and function 10 35758564
2019 Kolavenic acid analog restores growth in HSET-overproducing fission yeast cells and multipolar mitosis in MDA-MB-231 human cells. Bioorganic & medicinal chemistry 10 31753800
2024 Kinesin-14 HSET and KlpA are non-processive microtubule motors with load-dependent power strokes. Nature communications 9 39095439
2021 Kinesin Family Member C1 (KIFC1/HSET): A Potential Actionable Biomarker of Early Stage Breast Tumorigenesis and Progression of High-Risk Lesions. Journal of personalized medicine 9 34945833
2022 Kinesin-14 KIFC1 modulates spindle assembly and chromosome segregation in mouse spermatocytes. Experimental cell research 8 35259401
2022 An Integrative Pan-Cancer Analysis of Kinesin Family Member C1 (KIFC1) in Human Tumors. Biomedicines 8 35327439
2020 Bone morphogenetic protein 2 (BMP2) mediates spermatogenesis in Chinese mitten crab Eriocheir sinensis by regulating kinesin motor KIFC1 expression. Gene 8 32522697
2020 The Trypanosoma Brucei KIFC1 Kinesin Ensures the Fast Antibody Clearance Required for Parasite Infectivity. iScience 8 32889430
2024 CDK1 promotes the phosphorylation of KIFC1 to regulate the tumorgenicity of endometrial carcinoma. Journal of gynecologic oncology 7 38456590
2024 A novel role for KIFC1-MYH9 interaction in triple-negative breast cancer aggressiveness and racial disparity. Cell communication and signaling : CCS 7 38902769
2023 Kinesin Family Member C1 (KIFC1/HSET) Underlies Aggressive Disease in Androgen Receptor-Low and Basal-Like Triple-Negative Breast Cancers. International journal of molecular sciences 7 38003261
2024 The DDX6/KIFC1 signaling axis, as regulated by YY1, contributes to the malignant behavior of pancreatic cancer. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 6 38551642
2024 Targeting KIFC1 Promotes Senescence in Soft Tissue Sarcoma via FXR1-Dependent Regulation of MAD2L1 mRNA Stability. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 6 39387242
2022 Transport of Acrosomal Enzymes by KIFC1 via the Acroframosomal Cytoskeleton during Spermatogenesis in Macrobrachium rosenbergii (Crustacea, Decapoda, Malacostracea). Animals : an open access journal from MDPI 6 35454238
1999 Genomic organization of the HSET locus and the possible association of HLA-linked genes with immotile cilia syndrome (ICS). Immunogenetics 6 10369922
2025 KIFC1 in cancer: Understanding its expression, regulation, and therapeutic potential. Experimental cell research 5 40058447
2021 KIFC1 functions in nuclear reshaping and midpiece formation during the spermatogenesis of small yellow croaker Larimichthys polyactis. Animal reproduction science 5 33581918
2025 OTUD6B regulates KIFC1-dependent centrosome clustering and breast cancer cell survival. EMBO reports 4 39789388
2025 C/EBPβ increases tumor aggressiveness by enhancing KIFC1 expression in androgen receptor negative triple negative breast cancer. Cell communication and signaling : CCS 4 40448099
2023 KIFC1 promotes proliferation and pseudo-bipolar division of ESCC through the transportation of Aurora B kinase. Aging 4 37955677
2023 KIFC1 aggravates non-small-cell lung cancer cell proliferation and metastasis via provoking TGF-β/SMAD signal. Cellular and molecular biology (Noisy-le-Grand, France) 4 38279416
2024 FOXD1 activates KIFC1 to modulate aerobic glycolysis and reinforce cisplatin resistance of breast cancer. Reproductive biology 3 39541848
2023 Discovery of 2-(3-Benzamidopropanamido)thiazole-5-carboxylate Inhibitors of the Kinesin HSET (KIFC1) and the Development of Cellular Target Engagement Probes. Journal of medicinal chemistry 3 36749938
2022 The Roles of KIFC1 in the Development of Osteosarcoma: Characterization of Potential Therapeutic Targets. Computational and mathematical methods in medicine 3 35479190
2024 Screening of Reference Genes for Quantitative Real-Time PCR Analysis in Tissues and during Testis Development, and Application to Analyze the Expression of kifc1 in Hemibarbus labeo (Teleostei, Cypriniformes, Cyprinidae). Animals : an open access journal from MDPI 2 38998118
2023 Kinesin-14 KIFC1 promotes acrosome formation and chromatin maturation during mouse spermiogenesis. Biochimica et biophysica acta. Molecular cell research 2 37524262
2025 Loss of KIFC1 activity induces spindle instability and actin defects during porcine oocyte maturation. Theriogenology 1 39919850
2025 KIFC1 inhibition: Exploring the potential of propolis-derived small molecules for targeting cancer progression through in silico analysis. PloS one 1 40471955
2025 Meiotic progression in multinuclear mouse spermatocytes without the spindle pole clustering motor protein KIFC1 or cytokinesis forms single-cell late-stage spermatids. Scientific reports 1 41107451
2022 Kinesin-14 HSET may not oppose kinesin-5 Eg5 activity in RPE-1 cells. microPublication biology 1 36004005
2025 USP25-driven KIFC1 regulates MYCBP expression and promotes the progression of cervical cancer. Cell death & disease 0 40379626
2025 Two cancer cell lines utilize Myosin 10 and the kinesin HSET differentially to maintain mitotic spindle bipolarity. PloS one 0 40440343
2025 KIFC1 Overexpression Promotes Pancreatic Carcinoma Progression via Stabilising BUB1B. Journal of cellular and molecular medicine 0 40857057
2023 Kinesin-14 HSET and KlpA are non-processive microtubule motors with load-dependent power strokes. bioRxiv : the preprint server for biology 0 37333225

Missed literature

Know a paper Affinage missed for KIFC1? Flag it for the maintainers and the community.

No submissions yet.