Affinage

TUBA1B

Tubulin alpha-1B chain · UniProt P68363

Length
451 aa
Mass
50.2 kDa
Annotated
2026-06-10
77 papers in source corpus 12 papers cited in narrative 12 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 5/5 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

TUBA1B encodes the major ubiquitous α-tubulin isoform (K-alpha-1) that constitutes the principal α-tubulin isotype incorporated into microtubules in non-neuronal carcinoma cells and is subject to only low-level C-terminal mono-glutamylation, with extensive polyglutamylation and detyrosination absent in these contexts (PMID:11329278). Its incorporation into microtubules and the polymerization state of those microtubules are directly controlled by the C-terminal processing state of the encoded α-tubulin: expression of a Δ3-tubulin form from the endogenous TUBA1B promoter impairs mitotic spindle morphology and orientation and increases nuclear size, demonstrating direct control of spindle integrity during cell division (PMID:37930423). TUBA1B-containing microtubule polymerization is positively modulated by direct binding of the TCA-cycle metabolite malate, which promotes microtubule assembly to facilitate confined cell migration and metastasis (PMID:42151565), and is inhibited by direct interaction with the tight junction protein CLDN11 through its intracellular loop and C-terminus, which blocks tubulin polymerization and suppresses cell migration (PMID:29747653). TUBA1B is a direct pharmacological target: the microtubule-destabilizing agent TK216 binds TUBA1B-containing microtubules and resistance arises through TUBA1B mutations (PMID:35803262), and the small molecule asiatic acid binds TUBA1B directly (PMID:39479883). Loss-of-function studies place TUBA1B as a driver of tumor cell proliferation, migration, and invasion across glioma and colorectal cancer models (PMID:40094001, PMID:39259234), and its expression is positively regulated by MeCP2 (PMID:19174478).

Mechanistic history

Synthesis pass · year-by-year structured walk · 10 steps
  1. 2001 Medium

    Establishing which α-tubulin isotype and post-translational modification state predominates in non-neuronal human cells defined the molecular identity of the TUBA1B gene product in cancer contexts.

    Evidence MALDI-TOF mass spectrometry of C-terminal tubulin peptides from breast and lung carcinoma cell lines

    PMID:11329278

    Open questions at the time
    • Does not address modification state in neuronal or other tissues
    • Functional consequence of mono-glutamylation not tested
  2. 2009 Medium

    Identifying an upstream transcriptional regulator addressed how TUBA1B expression is controlled, linking it to MeCP2 function and cell morphology.

    Evidence Western blotting and genetic rescue in MeCP2-deficient mouse embryonic fibroblasts

    PMID:19174478

    Open questions at the time
    • Direct vs indirect transcriptional regulation not resolved
    • Whether MeCP2 binds the TUBA1B locus not shown
  3. 2018 Medium

    Discovery of a direct protein partner that inhibits polymerization explained one mechanism restraining TUBA1B-dependent microtubule assembly and migration.

    Evidence Reciprocal Co-IP/LC-MS/MS, domain mapping, and nocodazole rescue in NPC cells

    PMID:29747653

    Open questions at the time
    • Single lab
    • Structural basis of CLDN11-tubulin interaction not defined
  4. 2019 Medium

    Endogenous-locus fluorescent tagging established methodology for accurate single-molecule quantification of TUBA1B without overexpression artifacts.

    Evidence CRISPR-Cas9 knock-in of mEos variants at TUBA1B locus with PALM imaging

    PMID:31578415

    Open questions at the time
    • Primarily methodological
    • No new functional mechanism established
  5. 2022 High

    Genetic resistance mutations and reconstituted polymerization defined TUBA1B as the direct target of the microtubule-destabilizing agent TK216.

    Evidence Forward-genetics resistance screen, in vitro reconstituted MT polymerization, cell-based chemical probe competition in Ewing sarcoma cells

    PMID:35803262

    Open questions at the time
    • Precise binding-site residues not fully mapped
    • Isoform selectivity vs other α-tubulins not addressed
  6. 2023 Medium

    Driving a C-terminally processed Δ3-tubulin from the endogenous promoter showed that TUBA1B processing state directly governs mitotic spindle integrity.

    Evidence Endogenous TUBA1B-promoter-driven EGFP-Δ3-tubulin, spindle imaging, and nuclear size quantification in PANC-1 cells

    PMID:37930423

    Open questions at the time
    • Enzymes generating Δ3 form in vivo not identified
    • Single cell line
  7. 2024 High

    Multi-method target identification established asiatic acid as a direct TUBA1B binder, extending the gene's role as a druggable target.

    Evidence Photoaffinity chemical proteomics, SPR, pull-down, CETSA, DARTS, and docking in HepG2 cells

    PMID:39479883

    Open questions at the time
    • Downstream microtubule/functional consequence of asiatic acid binding not detailed
    • Binding site only modeled by docking
  8. 2024 Low

    Loss-of-function linked TUBA1B to inflammatory cytokine expression and proliferation in colorectal cancer cells.

    Evidence siRNA knockdown with cytokine expression and growth assays in Caco-2 and Colo-205

    PMID:39259234

    Open questions at the time
    • Single method beyond knockdown, no pathway placement beyond association
    • Mechanism connecting tubulin to cytokine expression unknown
  9. 2025 Medium

    Knockdown across glioma models placed TUBA1B upstream of proliferation, invasion, and autophagy, supporting a pro-tumorigenic role.

    Evidence siRNA knockdown with proliferation/migration/invasion/autophagy assays and mouse xenografts

    PMID:40094001

    Open questions at the time
    • Mechanistic link to autophagy not resolved
    • Direct effectors downstream of TUBA1B not identified
  10. 2026 Medium

    Identifying malate as a direct metabolite ligand revealed a metabolism-cytoskeleton axis whereby TUBA1B couples TCA-cycle output to microtubule assembly and metastasis.

    Evidence CRISPR metabolic screen, malate-TUBA1B interaction assays, and in vivo metastasis models with interaction mutants and ARE-deleted knock-in mice

    PMID:42151565

    Open questions at the time
    • Structural detail of malate binding site limited
    • Generality beyond colorectal cancer under mechanical compression not established

Open questions

Synthesis pass · forward-looking unresolved questions
  • How the enzymes and signals that set TUBA1B's C-terminal processing and modification state are regulated, and how these integrate with its ligand-dependent assembly control, remains unresolved.
  • No identification of the enzymes generating the Δ3 form in vivo
  • No structural model unifying malate, CLDN11, TK216, and asiatic acid binding sites
  • Tissue-specific modification regulation uncharacterized

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0005198 structural molecule activity 3
Localization
GO:0005856 cytoskeleton 2
Pathway
R-HSA-1640170 Cell Cycle 2
Partners
CLDN11MECP2

Evidence

Reading pass · 12 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2022 Forward-genetics screening in Ewing sarcoma (EWS) cell lines identified recurrent mutations in TUBA1B (encoding α-tubulin) that are sufficient to drive resistance to TK216. Using reconstituted microtubule (MT) polymerization in vitro and cell-based chemical probe competition assays, TK216 was demonstrated to act as an MT destabilizing agent that directly targets TUBA1B-containing microtubules. Forward-genetics hypermutation screen, in vitro reconstituted microtubule polymerization assay, cell-based chemical probe competition assay, active-site mutagenesis via spontaneous resistance mutations Cell chemical biology High 35803262
2001 Mass spectrometry analysis of human breast (MDA-MB-231) and lung (A549) carcinoma cell lines identified k-alpha 1 (TUBA1B) as the major α-tubulin isotype present. Only low-level mono-glutamylation of k-alpha 1 was detected; extensive polyglutamylation and detyrosination (Glu-tubulin) were absent in these non-neuronal lines. SDS-PAGE, CNBr digestion, MALDI-TOF mass spectrometry of C-terminal tubulin peptides Biochemistry Medium 11329278
2018 Co-immunoprecipitation and LC-MS/MS proteomics in NPC cells identified TUBA1B as a binding partner of the tight junction protein CLDN11. The interaction was mediated through the intracellular loop and C-terminus of CLDN11, and CLDN11 was shown to block tubulin polymerization and inhibit cell migration through this interaction. Co-immunoprecipitation, LC-MS/MS proteomics, domain-deletion functional assays, tubulin polymerization inhibitor (nocodazole) rescue experiment Journal of experimental & clinical cancer research : CR Medium 29747653
2009 In MeCP2-deficient mouse embryonic fibroblasts (MeCP2−/y MEFs), TUBA1B expression and tyrosinated α-tubulin protein levels were markedly reduced, causing deteriorated cell morphology. Reintroduction of human MeCP2 completely reversed these deficits, establishing MeCP2 as a positive regulator of TUBA1B expression in neuronal cells. Expression analysis of brain tissue from RTT/AS patients, Western blotting for tyrosinated α-tubulin in MeCP2−/y MEFs, genetic rescue by MeCP2 re-expression Human molecular genetics Medium 19174478
2024 Chemical proteomics (AfBPP photoaffinity probe with diazirine and alkyne), surface plasmon resonance, pull-down, cellular thermal shift assay (CETSA), and drug affinity responsive target stability (DARTS) assay collectively identified TUBA1B (α-tubulin alpha-1B chain) as a direct binding target of asiatic acid (AA) in HepG2 hepatoma cells. Molecular docking further characterized the interaction interface. Photoaffinity-based chemical proteomics (AfBPP), mass spectrometry, surface plasmon resonance, pull-down assay, CETSA, DARTS, molecular docking Organic & biomolecular chemistry High 39479883
2023 Expression of EGFP-tagged Δ3-tubulin driven by the endogenous TUBA1B promoter in PANC-1 pancreatic cancer cells impaired spindle body morphology and orientation during cell division (increased spindle bending, condensation defects) and increased nuclear size in a dose-dependent manner, demonstrating that the C-terminal processing state of TUBA1B-encoded α-tubulin directly controls mitotic spindle integrity. Endogenous promoter-driven EGFP-Δ3-tubulin expression (TUBA1B locus), live-cell/fixed imaging of spindle morphology, nuclear size quantification, cell proliferation assay Medical molecular morphology Medium 37930423
2019 CRISPR-Cas9 knock-in at the TUBA1B locus was used to introduce fluorescent protein (mEos) tags for single-molecule localization microscopy. More monomeric and codon-optimized mEos variants showed improved expression at the TUBA1B locus, enabling accurate single-molecule quantification of endogenously tagged protein compared to overexpressed constructs. CRISPR-Cas9 knock-in at TUBA1B locus, PALM (single-molecule localization microscopy), quantitative single-molecule imaging Scientific reports Medium 31578415
2026 In colorectal cancer cells, malate (produced via elevated DLD-driven TCA cycle metabolism under mechanical compression) was found to interact directly with TUBA1B to promote microtubule assembly, facilitating confined cell migration and metastasis. Disruption of the malate-TUBA1B interaction significantly suppressed tumor metastasis in vivo. CRISPR metabolic enzyme screen, biochemical interaction assays between malate and TUBA1B, in vivo xenograft/metastasis models with TUBA1B interaction mutants, ARE-deleted knock-in mice Cell research Medium 42151565
2025 In glioma cells, siRNA-mediated knockdown of TUBA1B reduced tumor cell proliferation, migration, invasion, and autophagy in vitro, and suppressed tumor growth in mouse xenograft models, placing TUBA1B upstream of cell cycle pathway regulation and intercellular communication in glioma progression. siRNA knockdown, in vitro proliferation/migration/invasion assays, autophagy assays, mouse xenograft model, qRT-PCR Frontiers in oncology Medium 40094001
2024 siRNA-mediated silencing of TUBA1B in colorectal cancer cell lines (Caco-2 and Colo-205) significantly reduced expression of pro-inflammatory cytokines IL-6, IL-7, CXCL1, and CXCL2, and inhibited tumor cell growth, identifying TUBA1B as a regulator of inflammatory signaling and tumor cell proliferation. siRNA knockdown, cytokine expression measurement, cell growth assay Discover oncology Low 39259234
1996 Semiquantitative RT-PCR analysis of paclitaxel-resistant MES-SA sarcoma mutants showed reduced transcript levels of specific β-tubulin isotypes (5β and β4) across all clones, while K-alpha-1 (TUBA1B) transcript levels were examined but not directly implicated in resistance; the study established that tubulin isotype expression changes (not involving TUBA1B) accompany selection for paclitaxel resistance. Semiquantitative RT-PCR, immunoblotting for total tubulin content, fluctuation analysis Cancer research Low 8640766
2025 Proteomics of stress granules (SGs) immunoprecipitated from postmortem frontal cortex of Alzheimer's disease patients showed reduced abundance of TUBA1B within SGs in rapidly progressive AD (rpAD) compared to controls and slowly progressive AD. Dysregulation of TUBA1B was also observed in 3xTg mouse model cortical tissue and human cortical homogenates, indicating cytoskeletal vulnerability and altered SG composition during aggressive AD progression. Anti-TIAR immunoprecipitation of stress granules, LC-MS/MS proteomics, Western blotting in human postmortem tissue and 3xTg mouse model bioRxivpreprint Low 41847015

Source papers

Stage 0 corpus · 77 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2010 Antibodies to self-antigens predispose to primary lung allograft dysfunction and chronic rejection. The Annals of thoracic surgery 114 20868794
1996 Resistance mechanisms in human sarcoma mutants derived by single-step exposure to paclitaxel (Taxol). Cancer research 113 8640766
2013 Non-HLA antibodies in solid organ transplantation: recent concepts and clinical relevance. Current opinion in organ transplantation 71 23838648
2019 High throughput circRNA sequencing analysis reveals novel insights into the mechanism of nitidine chloride against hepatocellular carcinoma. Cell death & disease 66 31506425
2018 Circulating Exosomes with Distinct Properties during Chronic Lung Allograft Rejection. Journal of immunology (Baltimore, Md. : 1950) 61 29491008
2010 Antihuman leukocyte antigen antibody-induced autoimmunity: role in chronic rejection. Current opinion in organ transplantation 61 19898237
2023 Large-scale rare variant burden testing in Parkinson's disease. Brain : a journal of neurology 42 37348876
2022 TK216 targets microtubules in Ewing sarcoma cells. Cell chemical biology 41 35803262
2018 Tissue-associated self-antigens containing exosomes: Role in allograft rejection. Human immunology 37 29908844
2021 Dynamic Network Biomarker of Pre-Exhausted CD8+ T Cells Contributed to T Cell Exhaustion in Colorectal Cancer. Frontiers in immunology 35 34434188
2022 Tubulin Alpha 1b Is Associated with the Immune Cell Infiltration and the Response of HCC Patients to Immunotherapy. Diagnostics (Basel, Switzerland) 31 35453905
2021 Significance of TERT Genetic Alterations and Telomere Length in Hepatocellular Carcinoma. Cancers 31 33946181
2001 Identification by mass spectrometry of a new alpha-tubulin isotype expressed in human breast and lung carcinoma cell lines. Biochemistry 31 11329278
2020 RP11-480I12.5-004 Promotes Growth and Tumorigenesis of Breast Cancer by Relieving miR-29c-3p-Mediated AKT3 and CDK6 Degradation. Molecular therapy. Nucleic acids 28 32810693
2018 Inactivation of the tight junction gene CLDN11 by aberrant hypermethylation modulates tubulins polymerization and promotes cell migration in nasopharyngeal carcinoma. Journal of experimental & clinical cancer research : CR 28 29747653
2024 Single-Cell Transcriptomic Analysis of Epstein-Barr Virus-Associated Hemophagocytic Lymphohistiocytosis. Journal of clinical immunology 23 38642164
2009 Expression of Na,K-ATPase-beta(1) subunit increases uptake and sensitizes carcinoma cells to oxaliplatin. Cancer chemotherapy and pharmacology 23 19322565
2024 Single-cell transcriptional atlas of tumor-associated macrophages in breast cancer. Breast cancer research : BCR 21 39232806
2009 MeCP2 involvement in the regulation of neuronal alpha-tubulin production. Human molecular genetics 20 19174478
2022 Behavioral changes and transcriptomic effects at embryonic and post-embryonic stages reveal the toxic effects of 2,2',4,4'-tetrabromodiphenyl ether on neurodevelopment in zebrafish (Danio rerio). Ecotoxicology and environmental safety 19 36423367
2019 Prevalence of antibodies to lung self-antigens (Kα1 tubulin and collagen V) and donor specific antibodies to HLA in lung transplant recipients and implications for lung transplant outcomes: Single center experience. Transplant immunology 18 30794945
2019 Optimised insert design for improved single-molecule imaging and quantification through CRISPR-Cas9 mediated knock-in. Scientific reports 17 31578415
2022 A novel HDAC11 inhibitor potentiates the tumoricidal effects of cordycepin against malignant peripheral nerve sheath tumor through the Hippo signaling pathway. American journal of cancer research 15 35261809
2019 The impact of non-HLA antibodies on outcomes after lung transplantation and implications for therapeutic approaches. Human immunology 15 31005400
2021 Lower levels of tubulin alpha 1b in the frontal pole in schizophrenia supports a role for changed cytoskeletal dynamics in the aetiology of the disorder. Psychiatry research 14 34274903
2020 Sensitivity to differential NRF1 gene signatures contributes to breast cancer disparities. Journal of cancer research and clinical oncology 14 32705365
2024 Deciphering the impact of aggregated autophagy-related genes TUBA1B and HSP90AA1 on colorectal cancer evolution: a single-cell sequencing study of the tumor microenvironment. Discover oncology 13 39259234
2021 Transcriptome-wide association study identifies multiple genes associated with childhood body mass index. International journal of obesity (2005) 13 33627773
2020 The Expression and Potential Role of Tubulin Alpha 1b in Wilms' Tumor. BioMed research international 13 32908931
2018 Comprehensive analysis of Reverse Phase Protein Array data reveals characteristic unique proteomic signatures for glioblastoma subtypes. Gene 13 30401645
2024 GLI1-Altered Mesenchymal Tumor-Multiomic Characterization of a Case Series and Patient-Level Meta-analysis of One Hundred Sixty-Seven Cases for Risk Stratification. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 12 39442668
1995 Structures of quinoxaline antibiotics. Acta crystallographica. Section B, Structural science 12 8554726
1991 Structure of a new cyclotetrapeptide trapoxin A. Acta crystallographica. Section C, Crystal structure communications 12 1930826
2023 The miR-221/222 cluster regulates hematopoietic stem cell quiescence and multipotency by suppressing both Fos/AP-1/IEG pathway activation and stress-like differentiation to granulocytes. PLoS biology 10 37983263
2012 Na,K-ATPase β-subunit cis homo-oligomerization is necessary for epithelial lumen formation in mammalian cells. Journal of cell science 10 23077177
2024 Epigallocatechin gallate induces apoptosis in multiple myeloma cells through endoplasmic reticulum stress induction and cytoskeletal disruption. International immunopharmacology 8 39159563
2023 From stability to reliability: Unveiling the un-biased reference genes in porcine ovarian granulosa cells under different conditions. Gene 8 38123003
2024 The significance of CD8+ tumor-infiltrating lymphocytes exhaustion heterogeneity and its underlying mechanism in diffuse large B-cell lymphoma. International immunopharmacology 7 38909497
2020 Direct Measurement of Single-Molecule Ligand-Receptor Interactions. The journal of physical chemistry. B 7 32790373
2013 Role of alloimmunity and autoimmunity in allograft rejection. Clinical transplants 7 25095525
2022 A trans-omics assessment of gene-gene interaction in early-stage NSCLC. Molecular oncology 6 36408734
2024 TBC1D4 antagonizes RAB2A-mediated autophagic and endocytic pathways. Autophagy 5 38964379
2023 Evaluating the Association Between Genetically Proxied Neurodevelopmental Language Phenotypes and the Risk of Primary Progressive Aphasia. Neurology 5 36889925
2022 Atomic force microscopy identifies the alteration of rheological properties of the cardiac fibroblasts in idiopathic restrictive cardiomyopathy. PloS one 5 36174041
1989 Structures of three DNA cross-linking agents, ethane-1,2-di(methylsulfonate), propane-1,3-di(methylsulfonate) and n-butane-1,4-di(methylsulfonate). Acta crystallographica. Section C, Crystal structure communications 5 2558689
2024 Identifying Candidate Gene Drivers Associated with Relapse in Pediatric T-Cell Acute Lymphoblastic Leukemia Using a Gene Co-Expression Network Approach. Cancers 4 38730619
2023 CRISPR/Cas9-Mediated Knockout of tnfaip1 in Zebrafish Plays a Role in Early Development. Genes 4 37239365
2018 Effect of Silver Nanoparticles on Protein Composition of Rat Liver Microsomal Fraction. Bulletin of experimental biology and medicine 4 30450525
2013 Detection of antibodies to self-antigens (K-alpha 1 tubulin, collagen I, II, IV, and V, myosin, and vimentin) by enzyme-linked immunosorbent assay (ELISA). Methods in molecular biology (Clifton, N.J.) 4 23775748
2025 The aggrephagy-related gene TUBA1B influences clinical outcomes in glioma patients by regulating the cell cycle. Frontiers in oncology 3 40094001
2025 Reserpine Causes Neuroendocrine Toxicity, Inducing Impairments in Cognition via Disturbing Hypothalamic-Pituitary-Thyroid Axis in Zebrafish. NeuroSci 3 40265358
2024 Noninvasive biomarkers for the detection of GERD-induced pulmonary injury. Surgical endoscopy 3 39266756
2024 Identification of α-tubulin alpha-1B chain as a target of asiatic acid using chemical proteomics in HepG2 hepatoma cells. Organic & biomolecular chemistry 3 39479883
2022 Placental Gene Transcript Proportions are Altered in the Presence of In Utero Arsenic and Cadmium Exposures, Genetic Variants, and Birth Weight Differences. Frontiers in genetics 3 35646058
2022 Validation of superior reference genes in mouse submandibular glands under developmental and functional regeneration states. International journal of molecular medicine 3 36069228
1992 Structure of the anti-malarial drug primaquine diphosphate. Acta crystallographica. Section C, Crystal structure communications 3 1627276
1989 Structure of a kappa-opioid receptor misfit: (1S,5R,8R,9R)-2'-hydroxy-5,9-dimethyl-8,2-epoxyethano-6,7-benzomorphan hydrochloride. Acta crystallographica. Section C, Crystal structure communications 3 2557866
2025 Targeting the Aryl Hydrocarbon Receptor to Attenuate IGF1R Signaling in Thyroid Eye Disease. Thyroid : official journal of the American Thyroid Association 2 40257057
2024 Higher levels of AKT-interacting protein in the frontal pole from people with schizophrenia are limited to a sub-group who have a marked deficit in cortical muscarinic M1 receptors. Psychiatry research 2 39236366
2024 Collagen-V and K-α-1 Tubulin Antibodies as Potential Markers of Unsuspected GERD-Related Lung Damage: Insights from a Cross-Sectional Analysis. Lung 2 39317885
2023 Identifying genes associated with resistance to KRAS G12C inhibitors via machine learning methods. Biochimica et biophysica acta. General subjects 2 37805078
2021 [Mechanism of puerarin reversing SH-SY5Y cell injury induced by Aβ_(1-42) based on proteomics]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 2 34402289
1992 Crystal structure of lactitol (4-O-beta-D-galactopyranosyl-D-glucitol). Carbohydrate research 2 1596932
2026 FOXM1 Signaling Network Transcriptionally Upregulates Expression of Proteins Involved in Mitotic Progression to Induce High Proliferation and Chromosomal Instability in Androgen Receptor-Low Triple-Negative Breast Cancer. International journal of molecular sciences 1 41751958
2025 Improving predictive accuracy in multiple myeloma using a plasma cell profile derived from single-cell RNA sequencing. Haematologica 1 40438979
2025 Exploring novel blood-based DNA methylation biomarkers for alzheimer's disease via targeted sequencing of highly variable CpG sites. BMC research notes 1 40796861
2025 Screening the composition of tubulin isotypes reveals the most abundant TUBB4B for ciliary polarity in ependymal cells. Journal of molecular cell biology 1 41459724
2023 Δ3-tubulin impairs mitotic spindle morphology and increases nuclear size in pancreatic cancer cells. Medical molecular morphology 1 37930423
1992 Crystal structure of lactitol (4-O-beta-D-galactopyranosyl-D-glucitol) dihydrate. Carbohydrate research 1 1596933
2026 A spatial and temporal atlas of tubulin isotype expression during neural crest EMT. bioRxiv : the preprint server for biology 0 41847015
2026 Highly efficient and scarless genome editing via essential-gene-coupled homology-directed repair. Genome research 0 41985988
2026 Compression-induced metabolic adaptation drives confined tumor cell migration and distant metastasis via malate-dependent microtubule reinforcement. Cell research 0 42151565
2026 Single-cell RNA sequencing reveals cadmium-induced cell-type-specific mechanisms of developmental neurotoxicity in human cortical organoids. Journal of hazardous materials 0 42208297
2025 Single-Cell Profiling of the Microenvironment in High-Risk Neuroblastoma. IUBMB life 0 40536225
1992 Crystal structure of lactitol (4-O-beta-D-galactopyranosyl-D-glucitol) trihydrate. Carbohydrate research 0 1423354
1991 Structures of 1-(3,3-dimethylamino)propyl naphtho[2,1-b]thiophene-4- carboxylate and N-(3,3-dimethylamino)propyl-8-methoxynaphtho[2,1- b]thiophene-4-carboxamide, intercalators into double-helical DNA. Acta crystallographica. Section C, Crystal structure communications 0 1805872
1989 Structure and absolute configuration of two stereoisomers of alpha,alpha'-[iminobis-(methylene)]bis(3,4-dihydro-2H-1-benzopyran-2- methanol) hydrobromide. Acta crystallographica. Section C, Crystal structure communications 0 2576841

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