Affinage

TUBB

Tubulin beta chain · UniProt P07437

Length
444 aa
Mass
49.7 kDa
Annotated
2026-06-13
43 papers in source corpus

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

No mechanistic discoveries found in literature.

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
No controlled-vocabulary terms were assigned to this entry.

Source papers

Stage 0 corpus · 43 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2012 Mutations in the β-tubulin gene TUBB5 cause microcephaly with structural brain abnormalities. Cell reports 150 23246003
1993 Galanin-receptor ligand M40 peptide distinguishes between putative galanin-receptor subtypes. Proceedings of the National Academy of Sciences of the United States of America 130 7504301
1993 Galanin receptor antagonists M40 and C7 block galanin-induced feeding. Brain research 94 7679604
2015 Mutations in Either TUBB or MAPRE2 Cause Circumferential Skin Creases Kunze Type. American journal of human genetics 67 26637975
1996 Galanin receptor antagonist M40 blocks galanin-induced choice accuracy deficits on a delayed-nonmatching-to-position task. Behavioral neuroscience 49 8919005
1998 Coadministration of galanin antagonist M40 with a muscarinic M1 agonist improves delayed nonmatching to position choice accuracy in rats with cholinergic lesions. The Journal of neuroscience : the official journal of the Society for Neuroscience 48 9634573
2019 The miR-195 Axis Regulates Chemoresistance through TUBB and Lung Cancer Progression through BIRC5. Molecular therapy oncolytics 42 31508486
1995 Galanin and the galanin antagonist M40 do not change fat intake in a fat-chow choice paradigm in rats. The American journal of physiology 36 7573550
2014 TUBB5 and its disease-associated mutations influence the terminal differentiation and dendritic spine densities of cerebral cortical neurons. Human molecular genetics 34 24833723
1997 Analysis of galanin and the galanin antagonist M40 on delayed non-matching-to-position performance in rats lesioned with the cholinergic immunotoxin 192 IgG-saporin. Behavioral neuroscience 34 9189270
1996 Feeding induced by pharmacological blockade of fatty acid metabolism is selectively attenuated by hindbrain injections of the galanin receptor antagonist, M40. Obesity research 31 8822757
1991 The tubB alpha-tubulin gene is essential for sexual development in Aspergillus nidulans. Genes & development 31 1936991
2016 Mutations in the murine homologue of TUBB5 cause microcephaly by perturbing cell cycle progression and inducing p53-associated apoptosis. Development (Cambridge, England) 29 26903504
2020 TUBB Variants Underlying Different Phenotypes Result in Altered Vesicle Trafficking and Microtubule Dynamics. International journal of molecular sciences 26 32085672
2017 Pathogenic Acanthamoeba castellanii Secretes the Extracellular Aminopeptidase M20/M25/M40 Family Protein to Target Cells for Phagocytosis by Disruption. Molecules (Basel, Switzerland) 23 29258252
1997 Sense and antisense RNA for the membrane associated 40 kDa subunit M40 of the insect V-ATPase. FEBS letters 22 9271213
1999 The effects on feeding of galanin and M40 when injected into the nucleus of the solitary tract, the lateral parabrachial nucleus, and the third ventricle. Physiology & behavior 21 10477058
1994 Presence of an expressed beta-tubulin gene (TUBB) in the HLA class I region may provide the genetic basis for HLA-linked microtubule dysfunction. Human genetics 20 8270253
2015 Effects of the Galanin Receptor Antagonist M40 on Cardiac Function and Remodeling in Rats with Heart Failure. Cardiovascular therapeutics 18 26177027
2000 The galanin receptor antagonist M40 blocks the central cardiovascular actions of the galanin N-terminal fragment (1-15). European journal of pharmacology 17 10884520
2019 Spectrum of clinical heterogeneity of β-tubulin TUBB5 gene mutations. Gene 14 30738969
2022 Silencing LINC00665 inhibits cutaneous melanoma in vitro progression and induces apoptosis via the miR-339-3p/TUBB. Journal of clinical laboratory analysis 13 35929185
1986 An expressed beta-tubulin gene, TUBB, is located on the short arm of human chromosome 6 and two related sequences are dispersed on chromosomes 8 and 13. Experimental cell research 13 3007184
2012 Mutational and structural analysis of L-N-carbamoylase reveals new insights into a peptidase M20/M25/M40 family member. Journal of bacteriology 12 22904279
2018 Intrafamiliar clinical variability of circumferential skin creases Kunze type caused by a novel heterozygous mutation of N-terminal TUBB gene. Clinical genetics 10 29427453
1999 Intracerebroventricular infusion of the galanin antagonist M40 attenuates heterosexual partner preference in ferrets. Behavioral neuroscience 10 10357463
2020 Clinical variability of TUBB-associated disorders: Diagnosis through reanalysis. American journal of medical genetics. Part A 9 33016642
2017 Brain-specific knockin of the pathogenic Tubb5 E401K allele causes defects in motor coordination and prepulse inhibition. Behavioural brain research 6 28130172
2011 Galanin receptor antagonist m35 but not m40 or c7 ameliorates cerulein-induced acute pancreatitis in mice. Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 6 21242707
2022 EHBP1, TUBB, and WWOX SNPs, Gene-Gene and Gene-Environment Interactions on Coronary Artery Disease and Ischemic Stroke. Frontiers in genetics 5 35559044
2021 Associations between TUBB-WWOX SNPs, their haplotypes, gene-gene, and gene-environment interactions and dyslipidemia. Aging 5 33612478
2023 Dynamics of TUBB protein with five majorly occurring natural variants: a risk of cortical dysplasia. Journal of molecular modeling 4 36928665
2022 Inherited bone marrow failure with macrothrombocytopenia due to germline tubulin beta class I (TUBB) variant. British journal of haematology 3 36207145
2012 In Vivo Replication and Pathogenesis of Vesicular Stomatitis Virus Recombinant M40 Containing Ebola Virus L-Domain Sequences. Infectious diseases 3 23794798
2023 Molecular detection of Trichomonas vaginalis from vaginal swabs collected in Copan TransystemTM M40 Amies media using the Hologic Panther test system. Diagnostic microbiology and infectious disease 2 38007913
2023 [Genetic analysis of a child with Complex cortical dysplasia with other brain malformations type 6 due to a p.M73V variant of TUBB gene]. Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics 1 37994139
2026 [Genetic analysis and prenatal diagnosis of structural brain abnormalities associated with TUBB gene c.155A>G variant]. Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics 0 41663304
2026 Tubulinopathy Case Series: Marked Intrafamilial Phenotypic Variability Associated With a Novel Missense TUBB Variant. American journal of medical genetics. Part A 0 42015805
2026 tubb5 knockout in zebrafish causes neurodevelopmental defects via notch pathways. Human molecular genetics 0 42241496
2025 Identification and validation of TUBB, CLTA, and FBXL5 as potential diagnostic markers of postmenopausal osteoporosis. Biomolecules & biomedicine 0 40791155
2025 Integrated bioinformatics and in vitro validation reveal TUBB as a core gene and therapeutic target in NAFLD-related hepatocellular carcinoma. International journal of biological macromolecules 0 41271048
2025 Mutations in the β-tubulin TUBB impair ciliogenesis and are associated with ciliopathy-like phenotypes. Nature communications 0 41309602
2023 Effects of Venlafaxine on the Size of Brain and Expression of , and Genes in BALB/c Mice. Psychopharmacology bulletin 0 37601086

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