- Length
- 504 aa
- Mass
- 55.7 kDa
- Annotated
- 2026-06-13
40 papers in source corpus
Mechanistic narrative
Synthesis pass · prose summary of the discoveries below
No mechanistic discoveries found in literature.
Mechanism profile
Synthesis pass · controlled-vocabulary classification · explore literature graph →
No controlled-vocabulary terms were assigned to this entry.
Source papers
Stage 0 corpus · 40 papers · ranked by NIH iCite citations
| Year | Title | Journal | Citations | PMID |
|---|---|---|---|---|
| 2017 | Mutations in signal recognition particle SRP54 cause syndromic neutropenia with Shwachman-Diamond-like features. | The Journal of clinical investigation | 126 | 28972538 |
| 1997 | Empty site forms of the SRP54 and SR alpha GTPases mediate targeting of ribosome-nascent chain complexes to the endoplasmic reticulum. | Cell | 109 | 9182758 |
| 2018 | Mutations in the SRP54 gene cause severe congenital neutropenia as well as Shwachman-Diamond-like syndrome. | Blood | 90 | 29914977 |
| 2006 | SRp54 (SFRS11), a regulator for tau exon 10 alternative splicing identified by an expression cloning strategy. | Molecular and cellular biology | 50 | 16943417 |
| 2000 | The crystal structure of the conserved GTPase of SRP54 from the archaeon Acidianus ambivalens and its comparison with related structures suggests a model for the SRP-SRP receptor complex. | Structure (London, England : 1993) | 49 | 10801496 |
| 1992 | A Mycoplasma protein homologous to mammalian SRP54 recognizes a highly conserved domain of SRP RNA. | Nucleic acids research | 41 | 1280809 |
| 2002 | RNA interference of signal peptide-binding protein SRP54 elicits deleterious effects and protein sorting defects in trypanosomes. | The Journal of biological chemistry | 36 | 12244113 |
| 1996 | Identification of a region of Bacillus subtilis Ffh, a homologue of mammalian SRP54 protein, that is essential for binding to small cytoplasmic RNA. | The Journal of biological chemistry | 33 | 8662730 |
| 1998 | A role for SRp54 during intron bridging of small introns with pyrimidine tracts upstream of the branch point. | Molecular and cellular biology | 31 | 9710626 |
| 1997 | Binding site of the M-domain of human protein SRP54 determined by systematic site-directed mutagenesis of signal recognition particle RNA. | Nucleic acids research | 28 | 9016569 |
| 1994 | The Srp54 GTPase is essential for protein export in the fission yeast Schizosaccharomyces pombe. | Molecular and cellular biology | 28 | 7969124 |
| 2021 | SRP54 mutations induce congenital neutropenia via dominant-negative effects on XBP1 splicing. | Blood | 27 | 33227812 |
| 1994 | The Bacillus subtilis SRP54 homologue, Ffh, has an intrinsic GTPase activity and forms a ribonucleoprotein complex with small cytoplasmic RNA in vivo. | Biochemical and biophysical research communications | 27 | 7511896 |
| 1994 | A structure for the signal sequence binding protein SRP54: 3D reconstruction from STEM images of single molecules. | Journal of structural biology | 26 | 7880651 |
| 2008 | Structures of SRP54 and SRP19, the two proteins that organize the ribonucleic core of the signal recognition particle from Pyrococcus furiosus. | PloS one | 23 | 18953414 |
| 1999 | Enhancing effect of Bacillus subtilis Ffh, a homologue of the SRP54 subunit of the mammalian signal recognition particle, on the binding of SecA to precursors of secretory proteins in vitro. | Journal of biochemistry | 23 | 9880811 |
| 1993 | Identification of RNA sequences and structural elements required for assembly of fission yeast SRP54 protein with signal recognition particle RNA. | Molecular and cellular biology | 23 | 8382769 |
| 2001 | An archaeal protein homologous to mammalian SRP54 and bacterial Ffh recognizes a highly conserved region of SRP RNA. | FEBS letters | 22 | 11696367 |
| 1998 | Protein SRP54 of human signal recognition particle: cloning, expression, and comparative analysis of functional sites. | Gene | 18 | 9511762 |
| 1996 | Bacillus subtilis Ffh, a homologue of mammalian SRP54, can intrinsically bind to the precursors of secretory proteins. | Biochemical and biophysical research communications | 18 | 8886007 |
| 2020 | Structural and Functional Impact of SRP54 Mutations Causing Severe Congenital Neutropenia. | Structure (London, England : 1993) | 17 | 33053321 |
| 1997 | Yarrowia lipolytica SRP54 homolog and translocation of Kar2p. | Yeast (Chichester, England) | 12 | 9178502 |
| 2020 | Congenital neutropenia with variable clinical presentation in novel mutation of the SRP54 gene. | Pediatric blood & cancer | 10 | 32277798 |
| 1995 | Modulation of the signal recognition particle 54-kDa subunit (SRP54) in rat preosteoblasts by the extracellular matrix. | The Journal of biological chemistry | 9 | 7673110 |
| 1994 | Structural and functional characterisation of the signal recognition particle-specific 54 kDa protein (SRP54) of tomato. | Molecular & general genetics : MGG | 9 | 7808407 |
| 2020 | SRP54 Negatively Regulates IFN-Beta Production and Antiviral Response by Targeting RIG-I and MDA5. | Virologica Sinica | 8 | 32767210 |
| 2002 | Systematic site-directed mutagenesis of human protein SRP54: interactions with signal recognition particle RNA and modes of signal peptide recognition. | Biochemistry | 8 | 12234178 |
| 2001 | Assembly of the human signal recognition particle (SRP): overlap of regions required for binding of protein SRP54 and assembly control. | RNA (New York, N.Y.) | 7 | 11680843 |
| 2022 | Acute myeloid leukemia in SRP54-mutated congenital neutropenia. | EJHaem | 6 | 35846055 |
| 2017 | The Exon Junction Complex and Srp54 Contribute to Hedgehog Signaling via ci RNA Splicing in Drosophila melanogaster. | Genetics | 5 | 28637711 |
| 2022 | Case Report: Association between cyclic neutropenia and SRP54 deficiency. | Frontiers in immunology | 4 | 36159802 |
| 2011 | Compositional and structural features related to thermal stability in the archaea SRP19 and SRP54 signal recognition particle proteins. | Journal of molecular evolution | 4 | 21505884 |
| 2004 | Two strategically placed base pairs in helix 8 of mammalian signal recognition particle RNA are crucial for the SPR19-dependent binding of protein SRP54. | RNA (New York, N.Y.) | 3 | 15037766 |
| 2021 | Cellular Traffic Jam and Disease Due to Mutations in SRP54. | Structure (London, England : 1993) | 2 | 33417891 |
| 2021 | Archaeal SRP RNA and SRP19 facilitate the assembly of SRP54-FtsY targeting complex. | Biochemical and biophysical research communications | 2 | 34116357 |
| 1999 | Systematic mutagenesis of the fission yeast Srp54 protein. | Current genetics | 2 | 10079327 |
| 2002 | Identification and characterization of Streptococcus pneumoniae Ffh, a homologue of SRP54 subunit of mammalian signal recognition particle. | Biochemical and biophysical research communications | 1 | 11922609 |
| 2026 | SRP54-related congenital neutropenia: a multidisciplinary effort. | BMJ case reports | 0 | 41638760 |
| 2025 | srp54 promotes motor neuron development and is required for motility in zebrafish. | Neuroscience | 0 | 40328346 |
| 2024 | SRP54 of black carp negatively regulates MDA5-mediated antiviral innate immunity. | Developmental and comparative immunology | 0 | 39173725 |
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