Affinage

XBP1

X-box-binding protein 1 · UniProt P17861

Length
261 aa
Mass
28.7 kDa
Annotated
2026-06-11
100 papers in source corpus 42 papers cited in narrative 41 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

XBP1 is a bZIP transcription factor central to the IRE1α arm of the unfolded protein response, whose activity is gated by an unconventional cytoplasmic splicing event: under ER stress IRE1 cleaves XBP1 mRNA to remove a short intron, producing a frameshift that converts the inert unspliced product into the potent transcriptional activator XBP1s, with ATF6 supplying the upstream transcriptional induction of XBP1 mRNA (PMID:11779464, PMID:32788214). This pathway is amplified and tuned at multiple levels—ATF4 downstream of PERK raises IRE1α to increase the splicing ratio (PMID:27052593), PERK-induced miR-30c-2* dampens XBP1 output (PMID:22431749), and the splicing reaction itself is set by CNP/RtcA remodeling of cleaved exon termini for RtcB ligation (PMID:30355738) and by IRE1-phosphorylated Pumilio that shields spliced XBP1 mRNA from regulated IRE1-dependent decay (PMID:35332141). XBP1s executes a broad, cell-type-specific transcriptional program: it maintains a core ER-folding/secretory gene set in all cells while directing tissue-specific targets, including direct control of the differentiation regulator Mist1 (PMID:17612490), and it is required for plasma cell differentiation and immunoglobulin/IL-6 production (PMID:12612580), adipogenesis via a C/EBPβ→XBP1→C/EBPα circuit (PMID:19490910), and osteoclastogenesis through direct transactivation of NFATc1 (PMID:26193638). In metabolism, XBP1s drives hepatic de novo lipogenesis and lipid homeostasis, governs a hepatic 12-hour clock cistrome, and controls oxidative proinsulin folding by inducing protein disulfide isomerases (PMID:19751410, PMID:33277471, PMID:29507125), while the unspliced isoform XBP1u carries out distinct, splicing-independent functions—stabilizing MDM2 to degrade p53 (PMID:29057323), stabilizing SREBP2 to drive cholesterol synthesis (PMID:35933495), and targeting β-catenin for degradation (PMID:34870453). XBP1 also acts as a survival and pro-tumorigenic factor: it supports survival under hypoxia (PMID:15342372), forms transcriptional complexes with HIF1α and MYC to potentiate their programs (PMID:24670641, PMID:29480818), and reshapes the tumor microenvironment by reprogramming dendritic-cell lipid metabolism and constraining T-cell effector function through glutamine-transporter regulation (PMID:26073941, PMID:30305738). In innate immunity it directly transactivates PTGS2/PTGES to enable prostaglandin E2 production (PMID:31320508).

Mechanistic history

Synthesis pass · year-by-year structured walk · 37 steps
  1. 2001 High

    Established the defining regulatory logic of XBP1: that its mRNA is the substrate of IRE1 cytoplasmic splicing, converting it by frameshift into an active transcription factor, with ATF6 inducing the message upstream.

    Evidence Molecular cloning, reporter and splicing assays in mammalian cells

    PMID:11779464

    Open questions at the time
    • Did not enumerate the downstream transcriptional program
    • Splicing machinery components (ligase, terminal processing) not resolved
  2. 2003 High

    Showed the IRE1-XBP1 splicing event is physiologically essential for a defined differentiation program, linking the UPR to plasma cell development and antibody secretion.

    Evidence Genetic rescue in XBP1-/- mouse B cells with differentiation and cytokine readouts

    PMID:12612580

    Open questions at the time
    • Direct target genes mediating the differentiation block not mapped here
    • How IL-4 controls XBP1 transcription mechanistically unresolved
  3. 2004 High

    Extended XBP1 beyond classical ER stress to hypoxia, defining it as a survival factor whose loss increases apoptosis—relevant to tumor biology.

    Evidence XBP1-deficient cells, clonogenic/apoptosis assays and xenografts

    PMID:15342372

    Open questions at the time
    • Survival-mediating target genes not identified
    • Spliced vs unspliced contribution under hypoxia not dissected
  4. 2007 High

    Resolved how one factor produces diverse outputs by mapping cell-type-specific cistromes, distinguishing a universal ER-maintenance set from tissue-specific targets such as Mist1.

    Evidence Genome-wide ChIP and expression profiling in muscle and secretory cells

    PMID:17612490

    Open questions at the time
    • Determinants of cell-type-specific motif selection not defined
    • Cofactors directing context-specific binding unknown at this stage
  5. 2009 High

    Defined XBP1 as a required node in metabolic differentiation and lipid synthesis, establishing direct promoter circuits in adipogenesis and hepatic lipogenesis.

    Evidence XBP1-deficient MEFs/3T3-L1, promoter ChIP, liver-specific knockout with lipid phenotyping

    PMID:19490910 PMID:19751410

    Open questions at the time
    • Whether lipogenic control is purely XBP1s-dependent left open here
    • Relationship between metabolic and ER-folding programs unresolved
  6. 2012 Medium

    Revealed inter-arm UPR cross-talk in which PERK-induced miR-30c-2* caps XBP1 output, showing XBP1 levels are set not just by splicing but by miRNA control.

    Evidence miRNA gain/loss-of-function with XBP1 measurement and PERK genetics

    PMID:22431749

    Open questions at the time
    • Single-lab finding
    • Quantitative contribution relative to splicing not established
  7. 2014 High

    Identified XBP1 as a partner that physically assembles with HIF1α to potentiate hypoxic transcription and drive TNBC tumorigenicity, beyond its canonical UPR role.

    Evidence ChIP-seq, Co-IP, shRNA depletion and xenografts

    PMID:24670641

    Open questions at the time
    • Interaction interface not mapped
    • Whether complex requires XBP1s splicing not formally isolated
  8. 2014 Medium

    Linked XBP1 to invasion programs by showing it upregulates Snail to drive EMT in breast cancer.

    Evidence siRNA/overexpression with marker and invasion assays

    PMID:25280941

    Open questions at the time
    • Direct vs indirect regulation of Snail not resolved
    • Single lab
  9. 2015 High

    Broadened the cell-fate program of XBP1s to osteoclast differentiation via direct NFATc1 transactivation, with IRE1 activation tied to ER Ca2+ oscillation.

    Evidence Conditional IRE1α KO mice, osteoclast assays, NFATc1-promoter ChIP

    PMID:26193638

    Open questions at the time
    • How Ca2+ oscillation feeds IRE1 mechanistically incomplete
  10. 2015 High

    Connected selective IRE1α-XBP1 activation to secretory protein maturation and disease, showing XBP1 is required for polycystin-1 GPS cleavage and ameliorates polycystic disease.

    Evidence SEC63/XBP1 double-KO mice, reciprocal Co-IP, GPS cleavage and XBP1s overexpression

    PMID:25844898

    Open questions at the time
    • Direct targets mediating PC1 maturation not fully enumerated
  11. 2015 High

    Established XBP1 as the adaptive resolver of hepatic ER stress, with its loss causing maladaptive UPR, injury and fibrosis.

    Evidence Liver-specific XBP1 KO with pharmacological ER stress

    PMID:26504083

    Open questions at the time
    • Did not separate loss-of-XBP1 effects from secondary IRE1α hyperactivation (resolved later)
  12. 2015 High

    Uncovered a pathogenic role in tumor immunity, showing constitutive XBP1 in tumor dendritic cells drives a lipid program that disables anti-tumor T-cell support.

    Evidence DC-specific XBP1 KO, nanoparticle silencing, lipid and T-cell assays, tumor models

    PMID:26073941

    Open questions at the time
    • Direct lipogenic target genes in tDCs not fully mapped
  13. 2016 Medium

    Showed feed-forward amplification of the pathway, with PERK/ATF4-driven IRE1α induction raising the XBP1 splicing ratio to prolong signaling.

    Evidence IRE1α/ATF4 knockdown with splicing-ratio time courses

    PMID:27052593

    Open questions at the time
    • Single lab
    • Quantitative impact on target output not measured
  14. 2017 High

    Distinguished a splicing-independent function: unspliced XBP1u stabilizes MDM2 via its unique C-terminus to promote p53 degradation, redefining the 'inactive' isoform as a functional regulator.

    Evidence shRNA screen, Co-IP, domain mapping, ubiquitination and cell-cycle assays

    PMID:29057323

    Open questions at the time
    • Cellular contexts where XBP1u-MDM2 axis dominates not delineated
  15. 2017 Medium

    Added direct proliferation- and inflammation-promoting target circuits, showing XBP1s transactivates Cyclin D1 and IL-6 in cancer.

    Evidence ChIP, luciferase, siRNA/ectopic expression and proliferation/STAT3 readouts

    PMID:26742428 PMID:28222747

    Open questions at the time
    • Single-lab findings per target
    • Cell-type generality not tested
  16. 2018 High

    Defined XBP1 as a metabolic brake on T-cell function in cancer, limiting glutamine influx and mitochondrial respiration to suppress IFNγ.

    Evidence T-cell-specific XBP1 KO, metabolomics, transporter and respiration assays, tumor models

    PMID:30305738

    Open questions at the time
    • Direct transporter-gene targets not all confirmed in this study
  17. 2018 High

    Showed reciprocal transcription-factor coupling, with MYC controlling IRE1 and forming a complex with XBP1, establishing XBP1 as a synthetic-lethal MYC partner.

    Evidence ChIP, Co-IP, XBP1 silencing in MYC-driven cells, PDX models

    PMID:29480818

    Open questions at the time
    • Structural basis of MYC-XBP1 complex unknown
  18. 2018 High

    Linked constitutive IRE1α-XBP1 to secretory cell physiology by showing it controls proinsulin oxidative folding via induction of multiple PDIs.

    Evidence β-cell-specific Ire1α KO and pathway reconstitution with insulin/PDI readouts

    PMID:29507125

    Open questions at the time
    • Direct XBP1 binding at all five PDI promoters not individually demonstrated
  19. 2018 High

    Connected XBP1 to inflammatory lipid mediator production, showing XBP1s directly transactivates PTGS2/PTGES for prostaglandin E2 synthesis in myeloid cells.

    Evidence IRE1α/XBP1-deficient myeloid cells, promoter transactivation, PGE2 and pain models

    PMID:31320508

    Open questions at the time
    • Stimulus-specific control of the COX-2/mPGES-1 module not fully parsed
  20. 2018 High

    Mechanistically defined splicing fidelity, showing CNP and RtcA antagonistically set XBP1 exon-terminus chemistry for RtcB ligation.

    Evidence In vitro splicing assays with CNP/RtcA manipulation

    PMID:30355738

    Open questions at the time
    • Physiological conditions modulating CNP/RtcA balance not defined
  21. 2019 High

    Extended XBP1 to muscle pathology, identifying a TLR/MyD88/XBP1 axis driving cancer cachexia-associated muscle wasting.

    Evidence Muscle-specific XBP1 KO, tumor-bearing model, myotube atrophy and overexpression

    PMID:31138662

    Open questions at the time
    • Atrophy-effector target genes downstream of XBP1 not mapped
  22. 2019 Medium

    Showed evolutionary conservation of XBP1s as a lipid-metabolism and longevity effector, acting via lysosomal lipase and FAT-6 desaturase in C. elegans.

    Evidence C. elegans transgenics, metabolomics and fat-6 epistasis

    PMID:31315038

    Open questions at the time
    • Direct transcriptional targets in the worm not mapped
    • Single-organism inference
  23. 2020 High

    Integrated XBP1 isoforms into nutrient signaling, showing AKT phosphorylates IRE1 to generate XBP1s for fed-state lipogenesis while XBP1u drives fasting gluconeogenesis.

    Evidence AKT/IRE1 phosphosite mapping, kinase assays, hepatocyte depletion/re-expression with isoform-specific readouts

    PMID:35863429

    Open questions at the time
    • Mechanism by which XBP1u potentiates cAMP-driven gluconeogenic genes unresolved
  24. 2020 High

    Resolved a long-standing ambiguity by genetic epistasis: XBP1-loss liver injury arises mainly from secondary IRE1α hyperactivation rather than loss of XBP1 transcriptional output.

    Evidence Hepatocyte XBP1/IRE1α single and double conditional KO with dietary challenge

    PMID:33219328

    Open questions at the time
    • RIDD substrate spectrum driving injury not enumerated
  25. 2020 High

    Linked XBP1 to circadian and membrane lipid homeostasis, defining a hepatic 12-hour cistrome whose loss promotes NAFLD.

    Evidence Liver-specific KO, 12-hour cistrome ChIP-seq, lipid/membrane fluidity assays

    PMID:33277471

    Open questions at the time
    • Relationship between 12-hour clock and canonical UPR targets unresolved
  26. 2021 High

    Expanded XBP1u's degradation-targeting role beyond MDM2, showing it directly binds β-catenin for proteasomal degradation independent of GSK-3β, suppressing vascular calcification.

    Evidence Interactome, Co-IP, domain mapping, ubiquitination, SMC-specific KO and rescue

    PMID:34870453

    Open questions at the time
    • E3 ligase used by XBP1u for β-catenin not identified
  27. 2021 Medium

    Showed XBP1s can act as a transcriptional repressor of tumor-suppressive and pro-apoptotic programs, suppressing TAp73 and PUMA to favor proliferation/survival.

    Evidence ChIP/luciferase with rescue (TAp73); inducible XBP1s RNA-seq with motif analysis (PUMA/IRE1)

    PMID:30473215 PMID:34636989

    Open questions at the time
    • Repressive cofactors enabling XBP1s repression not defined
    • Single-lab findings
  28. 2022 Medium

    Defined XBP1u as a driver of cholesterol biosynthesis by stabilizing SREBP2 to induce HMGCR, promoting hepatocellular carcinoma.

    Evidence Co-IP, ubiquitination/stability assays, HMGCR analysis and tumor growth

    PMID:35933495

    Open questions at the time
    • Single lab
    • Direct vs indirect SREBP2 stabilization mechanism partial
  29. 2022 High

    Connected XBP1s to innate immune signaling via mitophagy control, showing it represses BNIP3 to enhance cGAS/STING/NLRP3 activation and liver fibrosis.

    Evidence BNIP3-promoter ChIP, RNA-seq, myeloid XBP1 KO and BNIP3 knockdown in fibrosis models

    PMID:36185574

    Open questions at the time
    • Generality across macrophage subsets not tested
  30. 2022 Medium

    Added a paracrine immunosuppressive mechanism whereby cancer-cell XBP1 promotes cholesterol-laden extracellular vesicles that activate MDSCs.

    Evidence XBP1 depletion/inhibition, EV cholesterol quantification, MDSC and tumor assays

    PMID:36351432

    Open questions at the time
    • Which XBP1 isoform drives EV cholesterol secretion not specified
    • Single lab
  31. 2022 Medium

    Linked XBP1s to inflammasome priming by enhancing NLRP3 promoter activity in renal ischemia/reperfusion injury.

    Evidence NLRP3 promoter luciferase, XBP1 interference and in vivo renal IRI

    PMID:36801911

    Open questions at the time
    • Direct XBP1 occupancy at NLRP3 promoter not shown by ChIP
    • Single lab
  32. 2022 High

    Demonstrated metazoan conservation of post-transcriptional protection of spliced XBP1, with IRE1-phosphorylated Pumilio shielding it from RIDD.

    Evidence Drosophila genetics, in vitro IRE1 kinase assays, mRNA stability and 3'UTR binding

    PMID:35332141

    Open questions at the time
    • Whether the mammalian Pumilio orthologs perform the same role in vivo not established
  33. 2022 Medium

    Clarified pathway hierarchy, showing ATF6α is required for full XBP1 target induction but not for XBP1 splicing, and is itself independent of XBP1.

    Evidence Acute ATF6α knockdown in primary islets with timed ER stressors and target measurement

    PMID:32788214

    Open questions at the time
    • Molecular basis of ATF6α/XBP1 cooperativity at promoters not defined
    • Single lab
  34. 2023 Medium

    Extended XBP1 control to redox/cell-death pathways, defining an XBP1-Hrd1-Nrf2 axis promoting ferroptosis under high glucose.

    Evidence Co-IP, ubiquitylation assays and ferroptosis markers in high-glucose models

    PMID:37224754

    Open questions at the time
    • Whether Hrd1 is a direct XBP1 transcriptional target not shown by ChIP here
    • Single lab
  35. 2023 Medium

    Showed XBP1 represses a glutamine transporter (SLC38A2) to impair cytotoxic T cells in myeloma, paralleling its glutamine-limiting role in ovarian-cancer T cells.

    Evidence scRNA-seq, XBP1 gain/loss, SLC38A2-promoter ChIP and glutamine/T-cell assays

    PMID:37054944

    Open questions at the time
    • Single lab
    • Direct vs indirect repression mechanism not fully resolved
  36. 2023 Medium

    Defined XBP1's role in shaping adaptive immune polarization, promoting TIM4 in DCs and partnering with GATA3 (via RhoA) to drive Th2 IL-4 transcription.

    Evidence Xbp1-deficient T cells/DCs, promoter binding, XBP1-GATA3 Co-IP, GATA3 phosphorylation and airway allergy models

    PMID:35910793 PMID:37368951

    Open questions at the time
    • Mechanism of XBP1-induced GATA3 phosphorylation unresolved
    • Single lab
  37. 2024 Low

    Proposed XBP1 as a regulator of ferritinophagy via NCOA4, protecting against ferroptosis in ischemic kidney injury.

    Evidence XBP1 knockdown in H/R and I/R-AKI models with ferritinophagy/ferroptosis markers

    PMID:39061070

    Open questions at the time
    • No direct XBP1-NCOA4 binding evidence; pathway inferred indirectly
    • Single knockdown approach, single lab

Open questions

Synthesis pass · forward-looking unresolved questions
  • How the choice between XBP1s and XBP1u functions—and which isoform dominates in a given tissue or disease—is integrated with upstream kinase, splicing-fidelity, and cofactor inputs remains unresolved.
  • Structural basis of XBP1 partnerships with HIF1α, MYC and GATA3 unknown
  • E3 ligases and degradation machinery used by XBP1u not identified
  • Quantitative rules governing cell-type-specific cistromes undefined

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0003677 DNA binding 6 GO:0140110 transcription regulator activity 6 GO:0098772 molecular function regulator activity 3
Localization
GO:0005634 nucleus 4 GO:0005829 cytosol 3
Pathway
R-HSA-168256 Immune System 5 R-HSA-74160 Gene expression (Transcription) 5 R-HSA-1430728 Metabolism 4 R-HSA-1266738 Developmental Biology 3 R-HSA-392499 Metabolism of proteins 3 R-HSA-8953854 Metabolism of RNA 3 R-HSA-8953897 Cellular responses to stimuli 3
Partners
CTNNB1GATA3HIF1AIRE1MDM2MYCPUMSREBP2

Evidence

Reading pass · 41 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2001 XBP1 mRNA is a substrate of the IRE1 endoribonuclease in mammals; IRE1 performs unconventional cytoplasmic splicing of XBP1 mRNA under ER stress, producing a frameshift that generates a highly active transcription factor (spliced XBP1). Additionally, ATF6 induces transcription of XBP1 mRNA upstream of this splicing event. Molecular cloning, reporter assays, mRNA splicing analysis, and functional UPR activation assays in mammalian cells Cell High 11779464
2003 IRE1-mediated splicing of XBP1 is required for plasma cell differentiation and immunoglobulin production; only spliced XBP1 rescues immunoglobulin production in XBP1-/- B cells. IL-4 signaling controls XBP1 transcription during B cell differentiation, while immunoglobulin synthesis drives post-transcriptional XBP1 processing. XBP1 also controls IL-6 production, which is essential for plasma cell survival. Genetic rescue experiments in XBP1-/- mouse B cells, B cell differentiation assays, cytokine measurements Nature immunology High 12612580
2004 Hypoxia induces XBP1 at the transcriptional level and activates splicing of its mRNA, resulting in increased activated XBP1 protein. XBP1-deficient cells show increased apoptosis and decreased clonogenic survival under hypoxia, establishing XBP1 as an essential survival factor for hypoxic stress. Gene expression analysis, XBP1-deficient cell lines, clonogenic survival assays, apoptosis assays, tumor xenograft models Cancer research High 15342372
2004 Hepatitis C virus suppresses the IRE1-XBP1 pathway; HCV replicons elevate XBP1 expression but repress its trans-activating activity, preventing XBP1-dependent induction of EDEM (required for misfolded protein degradation). IRE1α-null MEFs with defective IRE1-XBP1 signaling show elevated HCV IRES-mediated translation. HCV replicon cell lines, XBP1 trans-activation assays, IRE1α-null MEFs, EDEM expression analysis The Journal of biological chemistry Medium 14960590
2007 Genome-wide mapping revealed that XBP1 regulates distinct target genes in different cell types through different sequence motifs; it controls a core ER-maintenance gene set in all cell types plus tissue-specific targets. XBP1 was found to directly regulate Mist1, a critical regulator of differentiation, explaining developmental defects in XBP1-null mice. Genome-wide ChIP, microarray expression profiling in skeletal muscle and secretory cells Molecular cell High 17612490
2009 The IRE1α-XBP1 pathway is indispensable for adipogenesis; C/EBPβ directly binds the Xbp1 proximal promoter to induce its expression, and XBP1 then binds the Cebpa promoter to activate C/EBPα expression. Only the IRE1α-spliced form of XBP1 (XBP1s) rescues adipogenic defects in XBP1-deficient cells. XBP1-deficient MEFs, 3T3-L1 knockdown, promoter ChIP assays, adipogenic differentiation assays, XBP1s rescue experiments Cell metabolism High 19490910
2009 XBP1 is required for de novo fatty acid synthesis in the liver; XBP1 protein expression is induced by high-carbohydrate diet and directly controls induction of genes involved in fatty acid synthesis. Liver-specific XBP1 deletion results in profound hypocholesterolemia and hypotriglyceridemia due to diminished hepatic lipid production. Inducible liver-specific XBP1 knockout mice, gene expression analysis, lipid measurements Annals of the New York Academy of Sciences High 19751410
2012 miR-30c-2* (miR-30c-2-3p) is induced by the PERK pathway of the UPR and directly suppresses XBP1 expression, limiting the scale of XBP1-mediated gene expression and influencing cell fate in the UPR. This represents a cross-talk mechanism where PERK signaling dampens IRE1/XBP1 output. miRNA induction assays, miRNA overexpression/inhibition, XBP1 protein/mRNA measurement, PERK pathway genetic approaches The Journal of cell biology Medium 22431749
2014 XBP1 promotes TNBC tumorigenicity by assembling a transcriptional complex with HIF1α that recruits RNA polymerase II to regulate HIF1α target gene expression. Genome-wide mapping of the XBP1 transcriptional regulatory network confirmed physical interaction of XBP1 with HIF1α. Genome-wide ChIP-seq, Co-immunoprecipitation, XBP1 depletion (shRNA), tumor xenograft models Nature High 24670641
2014 XBP1 regulates epithelial-to-mesenchymal transition (EMT) in breast cancer by upregulating the key EMT regulator Snail, leading to decreased E-cadherin and increased mesenchymal marker expression. XBP1 knockdown restores E-cadherin expression and suppresses cell invasion. siRNA knockdown, XBP1 overexpression, E-cadherin/mesenchymal marker expression assays, invasion assays Cellular signalling Medium 25280941
2015 Constitutive XBP1 activation in tumor-associated dendritic cells, fueled by lipid peroxidation byproducts, induces a triglyceride biosynthetic program leading to abnormal lipid accumulation and inhibition of anti-tumor T cell support. DC-specific XBP1 deletion or nanoparticle-mediated XBP1 silencing in tDCs restored immunostimulatory activity. DC-specific XBP1 conditional knockout mice, nanoparticle-mediated XBP1 silencing, lipid accumulation assays, T cell activation assays, tumor progression models Cell High 26073941
2015 XBP1 directly binds the promoter of NFATc1 and induces its transcription to drive osteoclastogenesis. IRE1α activation during osteoclastogenesis is partially dependent on Ca2+ oscillation via ITPR2 and ITPR3 in the ER. Conditional IRE1α knockout mice, osteoclast differentiation assays, ChIP for XBP1 binding to NFATc1 promoter, pharmacological inhibition of ITPR2/3 The Journal of clinical investigation High 26193638
2015 SEC63 deficiency selectively activates IRE1α-XBP1 in the ER; SEC63 exists in a complex with PC1 (polycystin-1). XBP1 is required for GPS cleavage and maturation of PC1; enforced XBP1s expression enhances GPS cleavage of PC1 and ameliorates polycystic disease. Murine genetic models (SEC63/XBP1 double knockout), co-immunoprecipitation, GPS cleavage assays, XBP1s overexpression The Journal of clinical investigation High 25844898
2015 Hepatic XBP1 controls the adaptive UPR response in the liver; liver-specific Xbp1 knockout mice cannot resolve ER stress, leading to sustained UPR activation, progressive liver injury, apoptosis, and fibrosis in response to pharmacological ER stress. Liver-specific Xbp1 knockout mice, pharmacological ER stress induction, liver injury/apoptosis/fibrosis assessment The Journal of biological chemistry High 26504083
2016 In addition to ATF6-mediated transcriptional induction of XBP1 mRNA, IRE1α expression is induced by ATF4 downstream of PERK under ER stress; increased IRE1α expression raises the XBP1 mRNA splicing ratio, amplifying and prolonging IRE1α-XBP1 pathway activation. IRE1α/ATF4 knockdown, XBP1 splicing ratio measurement, ER stress time-course experiments Scientific reports Medium 27052593
2017 Unspliced XBP1 (XBP1-u) negatively regulates the p53/p21 axis by binding and stabilizing MDM2 protein, inhibiting MDM2 self-ubiquitination and thereby enhancing p53 ubiquitination and degradation. The C-terminal domain of XBP1-u (which differs from XBP1-s due to a codon shift) mediates MDM2 binding. shRNA library screen, Co-immunoprecipitation, ubiquitination assays, domain mapping, cell cycle analysis Science advances High 29057323
2017 XBP1s directly binds the Cyclin D1 promoter to activate its expression, mediating IRE1α-dependent cell proliferation in colorectal cancer cells. ChIP, luciferase reporter assays, siRNA knockdown of IRE1α/XBP1, proliferation assays Biochemical and biophysical research communications Medium 26742428
2017 XBP1s binds the IL-6 promoter directly and activates its expression in melanoma cells; secreted IL-6 then activates JAK/STAT3 signaling in an autocrine/paracrine manner to promote melanoma cell proliferation. Inhibition of IRE1α RNase activity abolishes this effect. ChIP experiments, luciferase reporter assays, XBP1s ectopic expression, IRE1α inhibition, western blotting for STAT3 Journal of translational medicine Medium 28222747
2018 IRE1α-XBP1 activation in T cells suppresses mitochondrial activity and IFNγ production in ovarian cancer. Mechanistically, XBP1 induction regulates the abundance of glutamine carriers, limiting glutamine influx needed for mitochondrial respiration under glucose-deprived conditions. XBP1-deficient T cells show improved effector capacity. T cell-specific XBP1 deletion, metabolic assays, glutamine transporter expression analysis, mitochondrial respiration measurement, mouse tumor models Nature High 30305738
2018 MYC directly controls IRE1 transcription by binding to its promoter and enhancer. Furthermore, MYC forms a transcriptional complex with XBP1 and enhances XBP1 transcriptional activity. XBP1 is a synthetic lethal partner of MYC in breast cancer. ChIP for MYC binding to IRE1 promoter/enhancer, Co-immunoprecipitation of MYC-XBP1 complex, XBP1 silencing in MYC-hyperactivated cells, PDX mouse models The Journal of clinical investigation High 29480818
2018 IRE1α-XBP1 constitutive activation in pancreatic β cells regulates oxidative folding of proinsulin by controlling expression of five protein disulfide isomerases (PDI, PDIR, P5, ERp44, ERp46). Reconstitution of the IRE1α-XBP1 pathway in Ire1α-deleted insulinoma cells restored proinsulin content, insulin secretion, and PDI expression. β cell-specific Ire1α conditional knockout mice, Cre-loxP cell lines, insulin secretion assays, PDI expression analysis, IRE1α-XBP1 reconstitution The Journal of cell biology High 29507125
2018 XBP1s directly transactivates the human PTGS2 (COX-2) and PTGES genes to enable optimal prostaglandin E2 production in myeloid cells. IRE1α-XBP1-deficient myeloid cells show compromised induction of Cox-2 and mPGES-1 under ER stress or pattern recognition receptor stimulation. IRE1α-deficient myeloid cells, XBP1-deficient myeloid cells, ChIP/transactivation assays for PTGS2/PTGES promoters, PGE2 measurements, pain behavior models Science High 31320508
2018 2',3'-cyclic nucleotide phosphodiesterase (CNP) suppresses RtcB-mediated XBP1 splicing by hydrolyzing 2',3'-cyclic phosphate on cleaved XBP1 exon termini; conversely, RNA 3'-terminal cyclase (RtcA) facilitates XBP1 splicing by converting 2'-phosphate back to 2',3'-cyclic phosphate for RtcB ligation. In vitro splicing assays, mammalian cell lines, CNP/RtcA overexpression/knockdown, XBP1 splicing measurement The Journal of biological chemistry High 30355738
2019 Muscle-specific deletion of XBP1 ameliorates cancer cachexia-induced skeletal muscle wasting; overexpression of active XBP1 causes myotube atrophy. XBP1 acts downstream of TLR/MyD88 signaling to mediate muscle wasting, identifying a TLR/MyD88/XBP1 axis in cancer cachexia. Muscle-specific XBP1 conditional knockout mice, Lewis lung carcinoma tumor-bearing model, myotube atrophy assays, XBP1 overexpression Molecular and cellular biology High 31138662
2019 Constitutive XBP-1s expression in C. elegans increases lysosomal lipase activity and upregulates transcription of Δ9 desaturase FAT-6, increasing oleic acid levels; FAT-6 is required for the full lifespan extension induced by XBP-1s. C. elegans transgenic expression, metabolomics, fat-6 genetic epistasis, lysosomal lipase activity assays Cell reports Medium 31315038
2020 Insulin-activated kinase AKT directly phosphorylates IRE1 at S724, which mediates XBP1u mRNA splicing to generate XBP1s in mouse liver in the fed state, stimulating lipogenic gene expression. In the fasted state, XBP1u (not XBP1s) increases cAMP-stimulated gluconeogenic gene expression (G6pc, Pck1) and glucose production. AKT phosphorylation site mapping, in vitro kinase assays, hepatocyte-specific XBP1 depletion with re-expression, gluconeogenesis/lipogenesis assays, primary hepatocytes The Journal of biological chemistry High 35863429
2020 Hepatocyte-specific XBP1 deletion sensitizes mice to liver injury through hyperactivation of IRE1α (evidenced by XBP1 mRNA splicing, JNK activation, and RIDD). Concomitant deletion of both XBP1 and IRE1α protected mice from fructose-mediated liver injury, demonstrating that deleterious effects of XBP1 deletion are primarily due to IRE1α hyperactivation. Hepatocyte-specific single and double (XBP1/IRE1α) conditional knockout mice, dietary challenge, liver injury markers, IRE1α activity assays Cell death and differentiation High 33219328
2020 Liver-specific ablation of XBP1 disrupts the hepatic 12-hour clock and promotes NAFLD; XBP1s directly binds to the hepatic 12-hour cistrome. XBP1 ablation reduces membrane fluidity and impairs lipid homeostasis via fatty acid monounsaturation and phospholipid remodeling pathways. Liver-specific XBP1 knockout mice, ChIP-seq of 12-hour cistrome, genome-wide transcriptional profiling, lipid/membrane fluidity assays Nature communications High 33277471
2021 Unspliced XBP1 (XBP1u) directly binds β-catenin via amino acids 205–230 in its C-terminal degradation domain, promoting β-catenin ubiquitin-proteasomal degradation independently of the GSK-3β destruction complex, thereby inhibiting β-catenin/TCF-mediated transcription of Runx2 and Msx2 and suppressing vascular calcification. Interactome analysis, Co-immunoprecipitation, ubiquitination assays, domain mapping, smooth muscle cell-specific XBP1 knockout mice, vascular calcification models Circulation research High 34870453
2021 XBP1s directly binds the TAp73 promoter and suppresses its transcriptional activity, reducing p53-family tumor suppression and promoting colorectal cancer cell proliferation. TAp73 overexpression cancelled the pro-proliferative effect of XBP1s. ChIP for XBP1s binding to TAp73 promoter, luciferase reporter assays, XBP1s overexpression, TAp73 rescue experiments Biochemical and biophysical research communications Medium 30473215
2021 XBP1s genome-wide mRNA profiling identified XBP1 as a transcriptional repressor of PUMA (proapoptotic gene) and IRE1 mRNA expression during UPR, providing a negative feedback mechanism. Elevated XBP1 expression during ER stress had a prosurvival effect with reduced PUMA protein. XBP1s-inducible human cell line, siRNA silencing, next-generation RNA sequencing, bioinformatic analysis of XBP1-binding motifs Cellular and molecular life sciences Medium 34636989
2022 Unspliced XBP1 (XBP1-u) colocalizes with SREBP2 and inhibits its ubiquitination/proteasomal degradation, stabilizing SREBP2 and activating HMGCR transcription, thereby promoting cholesterol biosynthesis and tumorigenesis in hepatocellular carcinoma. Co-immunoprecipitation, ubiquitination assays, SREBP2 stability assays, HMGCR expression analysis, tumor growth experiments Cellular and molecular life sciences Medium 35933495
2022 Spliced XBP1 binds directly to the BNIP3 promoter and inhibits BNIP3 transcription in macrophages, thereby suppressing BNIP3-mediated mitophagy. Reduced mitophagy in Xbp1-expressing macrophages promotes cytosolic mtDNA leakage, activating cGAS/STING/NLRP3 signaling to drive liver fibrosis. Chromatin immunoprecipitation (ChIP) for XBP1 binding to Bnip3 promoter, RNA sequencing, myeloid-specific Xbp1 knockout mice, BNIP3 knockdown, liver fibrosis models JHEP reports High 36185574
2022 Cancer cell XBP1 favors synthesis and secretion of cholesterol in small extracellular vesicles; cholesterol is internalized by MDSCs via macropinocytosis, activating MDSCs and causing immunosuppression. XBP1 genetic or pharmacological depletion reduces MDSC abundance and triggers anti-tumor responses. XBP1 genetic depletion/pharmacological inhibition, extracellular vesicle isolation, cholesterol quantification, MDSC activation assays, tumor models Cell metabolism Medium 36351432
2022 Spliced XBP1 enhances the activity of the NLRP3 promoter (demonstrated by luciferase reporter assay), linking XBP1-mediated ER-mitochondria crosstalk to caspase-1-dependent inflammation in renal ischemia/reperfusion injury. Luciferase reporter assay for NLRP3 promoter, XBP1 interference in renal tubular cells, in vivo renal IRI model Cell death discovery Medium 36801911
2022 In Drosophila, IRE1-mediated phosphorylation of the RNA-binding protein Pumilio enables Pumilio to protect spliced Xbp1 mRNA from regulated Ire1-dependent decay (RIDD). hIRE1 can directly phosphorylate Pumilio, and phosphorylated Pumilio binds and stabilizes Xbp1spliced mRNA. Drosophila genetics, in vitro IRE1 kinase assays, mRNA stability assays, Pumilio binding site identification in Xbp1 3'UTR Nature communications High 35332141
2022 ATF6α is required for full activation of XBP1 target genes in pancreatic islet cells; acute ATF6α knockdown reduces induction of XBP1 targets without altering XBP1 mRNA splicing dynamics. XBP1 is not required for activation of ATF6α targets, establishing ATF6α as upstream of XBP1 target expression but not of XBP1 splicing. Acute ATF6α conditional knockdown in primary mouse islets (adenovirus-Cre), timed ER stressor exposures, transcriptional target gene measurement The Journal of biological chemistry Medium 32788214
2023 XBP1 overexpression increases Hrd1 expression; Hrd1 then interacts with and ubiquitinates Nrf2 under high-glucose conditions (confirmed by Co-IP and ubiquitylation assays), promoting ferroptosis via the XBP1-Hrd1-Nrf2 pathway in diabetic nephropathy. Co-immunoprecipitation, ubiquitylation assays, XBP1 overexpression, ferroptosis markers, high-glucose cell model Biomedicine & pharmacotherapy Medium 37224754
2023 XBP1 inhibits SLC38A2 (glutamine transporter) expression by directly binding to its promoter; reduced SLC38A2 decreases glutamine uptake and causes immune dysfunction in cytotoxic T cells in multiple myeloma. Single-cell RNA sequencing, in vitro XBP1 overexpression/inhibition, ChIP for XBP1 binding to SLC38A2 promoter, glutamine uptake assays, T cell functional assays Cancer letters Medium 37054944
2023 XBP1 in dendritic cells directly promotes TIM4 mRNA and protein expression in response to IL-2. RhoA facilitates binding between XBP1 and GATA3 in CD4+ T cells; XBP1 induces GATA3 phosphorylation to promote Il4 gene transcription and Th2 polarization. Xbp1-deficient CD4+ T cells and DCs, XBP1-TIM4 promoter binding assays, Co-IP for XBP1-GATA3 interaction, GATA3 phosphorylation assays, in vivo airway allergy models Science signaling / Theranostics Medium 35910793 37368951
2024 XBP1 upregulation promotes ferritinophagy via NCOA4; SeNPs protect against ferroptosis by upregulating XBP1, which in turn suppresses NCOA4-mediated ferritinophagy. XBP1 downregulation promoted ferritinophagy and partially counteracted protective effects on ferroptosis. In vitro H/R model, in vivo I/R-AKI mouse model, XBP1 knockdown, ferritinophagy and ferroptosis markers, lysosomal Fe2+ measurement Cell communication and signaling Low 39061070

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2001 XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor. Cell 3335 11779464
2015 ER Stress Sensor XBP1 Controls Anti-tumor Immunity by Disrupting Dendritic Cell Homeostasis. Cell 752 26073941
2003 Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1. Nature immunology 719 12612580
2014 XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway. Nature 704 24670641
2007 XBP1 controls diverse cell type- and condition-specific transcriptional regulatory networks. Molecular cell 688 17612490
2004 XBP1 is essential for survival under hypoxic conditions and is required for tumor growth. Cancer research 458 15342372
2018 IRE1α-XBP1 controls T cell function in ovarian cancer by regulating mitochondrial activity. Nature 354 30305738
2009 The IRE1alpha-XBP1 pathway of the unfolded protein response is required for adipogenesis. Cell metabolism 241 19490910
2004 Hepatitis C virus suppresses the IRE1-XBP1 pathway of the unfolded protein response. The Journal of biological chemistry 194 14960590
2018 Pharmacological targeting of MYC-regulated IRE1/XBP1 pathway suppresses MYC-driven breast cancer. The Journal of clinical investigation 193 29480818
2015 Targeting the IRE1α-XBP1 branch of the unfolded protein response in human diseases. Seminars in cancer biology 149 25986851
2022 Cancer cell-intrinsic XBP1 drives immunosuppressive reprogramming of intratumoral myeloid cells by promoting cholesterol production. Cell metabolism 142 36351432
2022 Role of XBP1 in regulating the progression of non-alcoholic steatohepatitis. Journal of hepatology 120 35292349
2019 IRE1α-XBP1 signaling in leukocytes controls prostaglandin biosynthesis and pain. Science (New York, N.Y.) 114 31320508
2016 Novel mechanism of enhancing IRE1α-XBP1 signalling via the PERK-ATF4 pathway. Scientific reports 113 27052593
2006 Targeting XBP-1 as a novel anti-cancer strategy. Cancer biology & therapy 108 16861911
2022 XBP1-mediated activation of the STING signalling pathway in macrophages contributes to liver fibrosis progression. JHEP reports : innovation in hepatology 104 36185574
2023 Endoplasmic reticulum stress-triggered ferroptosis via the XBP1-Hrd1-Nrf2 pathway induces EMT progression in diabetic nephropathy. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 102 37224754
2018 IRE1-XBP1 pathway regulates oxidative proinsulin folding in pancreatic β cells. The Journal of cell biology 102 29507125
2010 XBP1: the last two decades. Annals of the rheumatic diseases 102 19995749
2020 The emerging role of XBP1 in cancer. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 97 32294597
2012 MicroRNA-30c-2* limits expression of proadaptive factor XBP1 in the unfolded protein response. The Journal of cell biology 96 22431749
2010 Emerging roles for XBP1, a sUPeR transcription factor. Gene expression 95 21061914
2019 XBP-1 Remodels Lipid Metabolism to Extend Longevity. Cell reports 94 31315038
2015 Involvement of the IRE1α-XBP1 pathway and XBP1s-dependent transcriptional reprogramming in metabolic diseases. DNA and cell biology 89 25216212
2014 XBP1 induces snail expression to promote epithelial- to-mesenchymal transition and invasion of breast cancer cells. Cellular signalling 89 25280941
2016 XBP1: A Pivotal Transcriptional Regulator of Glucose and Lipid Metabolism. Trends in endocrinology and metabolism: TEM 80 26803729
2021 XBP1 regulates the protumoral function of tumor-associated macrophages in human colorectal cancer. Signal transduction and targeted therapy 79 34667145
2018 ZIKV infection activates the IRE1-XBP1 and ATF6 pathways of unfolded protein response in neural cells. Journal of neuroinflammation 79 30241539
2021 Unspliced XBP1 Counteracts β-Catenin to Inhibit Vascular Calcification. Circulation research 78 34870453
2011 Stressed out about obesity: IRE1α-XBP1 in metabolic disorders. Trends in endocrinology and metabolism: TEM 76 21703863
2015 Activation of IRE1α-XBP1 pathway induces cell proliferation and invasion in colorectal carcinoma. Biochemical and biophysical research communications 66 26742428
2009 From sugar to fat: How the transcription factor XBP1 regulates hepatic lipogenesis. Annals of the New York Academy of Sciences 66 19751410
2017 XBP1-FoxO1 interaction regulates ER stress-induced autophagy in auditory cells. Scientific reports 65 28667325
2022 Unfolded protein response IRE1/XBP1 signaling is required for healthy mammalian brain aging. The EMBO journal 64 36314651
2009 Genetic variation of promoter sequence modulates XBP1 expression and genetic risk for vitiligo. PLoS genetics 64 19543371
2015 XBP1 mitigates aminoglycoside-induced endoplasmic reticulum stress and neuronal cell death. Cell death & disease 62 25973683
2009 IRE1alpha controls cyclin A1 expression and promotes cell proliferation through XBP-1. Cell stress & chaperones 60 20013084
2019 Unravel the molecular mechanism of XBP1 in regulating the biology of cancer cells. Journal of Cancer 59 31205564
2017 IRE1α-XBP1 pathway promotes melanoma progression by regulating IL-6/STAT3 signaling. Journal of translational medicine 55 28222747
2010 Endoplasmic reticulum Ca2+ depletion activates XBP1 and controls terminal differentiation in keratinocytes and epidermis. The British journal of dermatology 55 20846312
2015 IRE1α/XBP1-mediated branch of the unfolded protein response regulates osteoclastogenesis. The Journal of clinical investigation 54 26193638
2015 Sec63 and Xbp1 regulate IRE1α activity and polycystic disease severity. The Journal of clinical investigation 52 25844898
2020 Targeting the IRE1-XBP1 axis to overcome endocrine resistance in breast cancer: Opportunities and challenges. Cancer letters 51 32446861
2020 XBP1 links the 12-hour clock to NAFLD and regulation of membrane fluidity and lipid homeostasis. Nature communications 51 33277471
2015 Hepatic Xbp1 Gene Deletion Promotes Endoplasmic Reticulum Stress-induced Liver Injury and Apoptosis. The Journal of biological chemistry 48 26504083
2024 CircPDIA3/miR-449a/XBP1 feedback loop curbs pyroptosis by inhibiting palmitoylation of the GSDME-C domain to induce chemoresistance of colorectal cancer. Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 46 38861804
2019 The Toll-Like Receptor/MyD88/XBP1 Signaling Axis Mediates Skeletal Muscle Wasting during Cancer Cachexia. Molecular and cellular biology 46 31138662
2018 IRE1α-XBP1 signaling pathway regulates IL-6 expression and promotes progression of hepatocellular carcinoma. Oncology letters 46 30214606
2020 Intersection of the ATF6 and XBP1 ER stress pathways in mouse islet cells. The Journal of biological chemistry 45 32788214
2017 Identification of XBP1-u as a novel regulator of the MDM2/p53 axis using an shRNA library. Science advances 45 29057323
2016 IRE1α-XBP1 signaling pathway, a potential therapeutic target in multiple myeloma. Leukemia research 43 27518808
2022 Spliced or Unspliced, That Is the Question: The Biological Roles of XBP1 Isoforms in Pathophysiology. International journal of molecular sciences 41 35269888
2020 Protein Palmitoylation Regulates Cell Survival by Modulating XBP1 Activity in Glioblastoma Multiforme. Molecular therapy oncolytics 40 33024813
2023 XBP1 modulates endoplasmic reticulum and mitochondria crosstalk via regulating NLRP3 in renal ischemia/reperfusion injury. Cell death discovery 39 36801911
2017 The requirement of IRE1 and XBP1 in resolving physiological stress during Drosophila development. Journal of cell science 38 28775151
2015 Epithelial Xbp1 is required for cellular proliferation and differentiation during mammary gland development. Molecular and cellular biology 37 25713103
2021 Genome-wide mRNA profiling identifies X-box-binding protein 1 (XBP1) as an IRE1 and PUMA repressor. Cellular and molecular life sciences : CMLS 35 34636989
2021 Scutellarin ameliorates hepatic lipid accumulation by enhancing autophagy and suppressing IRE1α/XBP1 pathway. Phytotherapy research : PTR 33 34859513
2020 X-box binding protein 1 (XBP1) function in diseases. Cell biology international 33 33325615
2022 Unspliced XBP1 contributes to cholesterol biosynthesis and tumorigenesis by stabilizing SREBP2 in hepatocellular carcinoma. Cellular and molecular life sciences : CMLS 32 35933495
2004 X-box binding protein 1 (XBP1) C--116G polymorphisms in bipolar disorders and age of onset. Neuroscience letters 32 15331160
2024 Selenium nanoparticles alleviate renal ischemia/reperfusion injury by inhibiting ferritinophagy via the XBP1/NCOA4 pathway. Cell communication and signaling : CCS 31 39061070
2020 Hepatocyte-specific deletion of XBP1 sensitizes mice to liver injury through hyperactivation of IRE1α. Cell death and differentiation 31 33219328
2022 Hyperlipidemia induces proinflammatory responses by activating STING pathway through IRE1α-XBP1 in retinal endothelial cells. The Journal of nutritional biochemistry 29 36370931
2009 Expression pattern of XBP1(S) in human B-cell lymphomas. Haematologica 29 19176362
2023 The transcription factor XBP1 in dendritic cells promotes the TH2 cell response in airway allergy. Science signaling 28 37368951
2022 Genetic and pharmacological inhibition of XBP1 protects against APAP hepatotoxicity through the activation of autophagy. Cell death & disease 28 35145060
2015 Spliced XBP1 promotes macrophage survival and autophagy by interacting with Beclin-1. Biochemical and biophysical research communications 28 26026678
2015 XBP1 silencing decreases glioma cell viability and glycolysis possibly by inhibiting HK2 expression. Journal of neuro-oncology 28 26680227
2020 IRE1α Promotes Zika Virus Infection via XBP1. Viruses 27 32138181
2020 MiR-34a-5p inhibits fibroblast‑like synoviocytes proliferation via XBP1. European review for medical and pharmacological sciences 27 33275235
2017 PERK and XBP1 differentially regulate CXCL10 and CCL2 production. Experimental eye research 27 28065589
2013 Unfolded protein response inducers tunicamycin and dithiothreitol promote myeloma cell differentiation mediated by XBP-1. Clinical and experimental medicine 27 24356728
2022 Regulatory network of BLIMP1, IRF4, and XBP1 triad in plasmacytic differentiation and multiple myeloma pathogenesis. Cellular immunology 25 36081178
2021 XBP1- IGFBP3 Signaling Pathway Promotes NSCLC Invasion and Metastasis. Frontiers in oncology 25 34094948
2023 Single-cell RNA sequencing reveals XBP1-SLC38A2 axis as a metabolic regulator in cytotoxic T lymphocytes in multiple myeloma. Cancer letters 23 37054944
2022 Pumilio protects Xbp1 mRNA from regulated Ire1-dependent decay. Nature communications 23 35332141
2024 The IRE1α/XBP1 pathway sustains cytokine responses of group 3 innate lymphoid cells in inflammatory bowel disease. The Journal of clinical investigation 22 38722686
2023 Macrophage RIPK3 triggers inflammation and cell death via the XBP1-Foxo1 axis in liver ischaemia-reperfusion injury. JHEP reports : innovation in hepatology 22 37841640
2022 Activation of the canonical ER stress IRE1-XBP1 pathway by insulin regulates glucose and lipid metabolism. The Journal of biological chemistry 22 35863429
2022 IRE1/XBP1 and endoplasmic reticulum signaling - from basic to translational research for cardiovascular disease. Current opinion in physiology 22 37207249
2019 IRE1-XBP1 Pathway of the Unfolded Protein Response Is Required during Early Differentiation of C2C12 Myoblasts. International journal of molecular sciences 22 31888027
2015 X-box binding protein 1 (XBP-1) enhances colorectal cancer cell invasion. Journal of chemotherapy (Florence, Italy) 21 25692573
2022 XBP1 is required in Th2 polarization induction in airway allergy. Theranostics 20 35910793
2020 Palmitate-Induced IRE1-XBP1-ZEB Signaling Represses Desmoplakin Expression and Promotes Cancer Cell Migration. Molecular cancer research : MCR 20 33106375
2020 Intracellular XBP1-IL-24 axis dismantles cytotoxic unfolded protein response in the liver. Cell death & disease 19 31907348
2018 XBP1-s promotes colorectal cancer cell proliferation by inhibiting TAp73 transcriptional activity. Biochemical and biophysical research communications 19 30473215
2017 The Multiple Roles of XBP1 in Regulation of Glucose and Lipid Metabolism. Current protein & peptide science 19 27356931
2022 UPR Responsive Genes Manf and Xbp1 in Stroke. Frontiers in cellular neuroscience 18 35783104
2019 XBP1 signalling is essential for alleviating mutant protein aggregation in ER-stress related skeletal disease. PLoS genetics 18 31260448
2017 TLR7-mediated activation of XBP1 correlates with the IFNα production in humans. Cytokine 18 28408069
2021 Cell cycle-independent integration of stress signals by Xbp1 promotes Non-G1/G0 quiescence entry. The Journal of cell biology 17 34694336
2018 The cyclic phosphodiesterase CNP and RNA cyclase RtcA fine-tune noncanonical XBP1 splicing during ER stress. The Journal of biological chemistry 17 30355738
2022 Activating ATF6 in spinal muscular atrophy promotes SMN expression and motor neuron survival through the IRE1α-XBP1 pathway. Neuropathology and applied neurobiology 15 35338505
2021 Electroacupuncture Pretreatment Mitigates Myocardial Ischemia/Reperfusion Injury via XBP1/GRP78/Akt Pathway. Frontiers in cardiovascular medicine 15 34195232
2019 XBP1 inhibits mesangial cell apoptosis in response to oxidative stress via the PTEN/AKT pathway in diabetic nephropathy. FEBS open bio 15 31077568
2018 The interaction between XBP1 and eNOS contributes to endothelial cell migration. Experimental cell research 15 29352987
2018 XBP1 and PERK Have Distinct Roles in Aβ-Induced Pathology. Molecular neurobiology 15 29427089
2023 XBP1 Modulates the Aging Cardiorenal System by Regulating Oxidative Stress. Antioxidants (Basel, Switzerland) 14 38001786

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