{"gene":"SRP54","run_date":"2026-06-13T19:06:35","timeline":{"discoveries":[],"current_model":"Parse failed"},"narrative":{"mechanistic_narrative":"No mechanistic discoveries found in literature.","teleology":[],"mechanism_profile":null},"prefetch_data":{"uniprot":{"accession":"P61011","full_name":"Signal recognition particle subunit SRP54","aliases":["Signal recognition particle 54 kDa protein"],"length_aa":504,"mass_kda":55.7,"function":"Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (PubMed:34020957). As part of the SRP complex, associates with the SRP receptor (SR) component SRPRA to target secretory proteins to the endoplasmic reticulum membrane (PubMed:34020957). Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes (PubMed:34020957). Displays basal GTPase activity, and stimulates reciprocal GTPase activation of the SR subunit SRPRA (PubMed:28972538, PubMed:34020957). Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SR subunit SRPRA (PubMed:34020957). SR compaction and GTPase mediated rearrangement of SR drive SRP-mediated cotranslational protein translocation into the ER (PubMed:34020957). Requires the presence of SRP9/SRP14 and/or SRP19 to stably interact with RNA (By similarity). Plays a role in proliferation and differentiation of granulocytic cells, neutrophils migration capacity and exocrine pancreas development (PubMed:28972538, PubMed:29914977)","subcellular_location":"Nucleus speckle; Cytoplasm; Endoplasmic reticulum","url":"https://www.uniprot.org/uniprotkb/P61011/entry"},"depmap":{"release":"DepMap","has_data":true,"is_common_essential":true,"resolved_as":"","url":"https://depmap.org/portal/gene/SRP54","classification":"Common 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SCN8","url":"https://www.omim.org/entry/618752"},{"mim_id":"612177","title":"RNA, 7SL, CYTOPLASMIC 1; RN7SL1","url":"https://www.omim.org/entry/612177"},{"mim_id":"604858","title":"SIGNAL RECOGNITION PARTICLE, 68-KD; SRP68","url":"https://www.omim.org/entry/604858"},{"mim_id":"604857","title":"SIGNAL RECOGNITION PARTICLE, 54-KD; SRP54","url":"https://www.omim.org/entry/604857"}],"hpa":{"profiled":true,"resolved_as":"","reliability":"Approved","locations":[{"location":"Cytosol","reliability":"Approved"}],"tissue_specificity":"Low tissue specificity","tissue_distribution":"Detected in 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