Affinage

SGPL1

Sphingosine-1-phosphate lyase 1 · UniProt O95470

Length
568 aa
Mass
63.5 kDa
Annotated
2026-06-10
100 papers in source corpus 8 papers cited in narrative 8 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 5/5 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

SGPL1 is the intracellular lyase that irreversibly cleaves sphingosine-1-phosphate (S1P) into ethanolamine phosphate and a long-chain aldehyde, an activity that simultaneously terminates S1P signaling and channels the ethanolamine phosphate product into phosphatidylethanolamine (PE) synthesis (PMID:28521611). In neurons, this SGPL1-derived PE is required for autophagy: neural-specific ablation lowers brain PE, impairs LC3-I→LC3-II conversion, accumulates unclosed phagophore-like structures and SQSTM1/BECN1, and blocks autophagic flux, defects rescued by exogenous PE (PMID:28521611). The degradative arm of this enzyme controls S1P abundance across multiple tissues, and its loss produces a multi-systemic disease (SPLIS): AAV9 delivery of human SGPL1 to Sgpl1-knockout mice restores enzymatic activity, normalizes S1P/sphingosine/ceramide, and prevents nephrosis, neurodevelopmental delay, anemia and hypercholesterolemia, establishing that enzymatic deficiency is the root cause (PMID:33755599). S1P accumulation upon SGPL1 loss disrupts mitochondrial morphology and oxidative phosphorylation (PMID:32682944) and impairs gonadal germ-cell development through distinct downstream effectors—reduced NPR2 activity in ovarian granulosa cells and elevated p21-driven Leydig-cell apoptosis in the testis (PMID:34083520). SGPL1 also localizes to the plasma membrane of mammary epithelial cells, where it degrades extracellular S1P and restrains S1P-dependent cell migration (PMID:29718989).

Mechanistic history

Synthesis pass · year-by-year structured walk · 5 steps
  1. 2017 High

    Established that SGPL1's cleavage of S1P does more than terminate signaling—its ethanolamine phosphate product feeds PE synthesis required for autophagosome membrane lipidation in neurons, linking sphingolipid catabolism to autophagy.

    Evidence Conditional neural knockout mouse, LC3 flux reporter, lipidomics, EM, and PE rescue in cultured neurons

    PMID:28521611

    Open questions at the time
    • Does not establish whether peripheral tissues use the same PE-dependent autophagy link
    • Mechanism connecting ethanolamine phosphate to specific PE pools at the phagophore not resolved
  2. 2020 Medium

    Showed that SGPL1 activity is required for normal mitochondrial morphology and respiration, identifying a mitochondrial dimension to the cellular consequences of S1P/sphingolipid accumulation.

    Evidence Patient-derived fibroblasts and CRISPR-KO HeLa cells with sphingolipid mass spectrometry and mitochondrial functional assays

    PMID:32682944

    Open questions at the time
    • Direct molecular link between accumulated S1P and mitochondrial dysfunction not defined
    • Single lab; two cellular models only
  3. 2021 High

    Demonstrated in vivo that restoring SGPL1 enzymatic activity reverses the multi-systemic SPLIS phenotype, proving enzyme deficiency is causal rather than correlative.

    Evidence AAV9 gene transfer in Sgpl1-KO mice with survival, sphingolipid MS, histopathology, and STAT3/cytokine analysis

    PMID:33755599

    Open questions at the time
    • Tissue-specific contributions to each phenotype not dissected
    • Mechanism of renal STAT3 activation downstream of S1P not resolved
  4. 2021 Medium

    Resolved how S1P accumulation impairs reproduction, showing tissue-divergent downstream effectors (NPR2 in ovary, p21/apoptosis in testis) rather than a single shared pathway.

    Evidence Sgpl1-KO mice with gonadal S1P quantification, granulosa NPR2 activity assay, and Leydig-cell p21/apoptosis measurements

    PMID:34083520

    Open questions at the time
    • How S1P modulates NPR2 activity mechanistically is unknown
    • Single lab; receptor mediating S1P effects on each cell type not identified
  5. 2018 Medium

    Extended SGPL1 localization beyond the ER/cytoplasm to the plasma membrane, where it degrades extracellular S1P and restrains migration—implicating its loss in cancer cell motility.

    Evidence Immunofluorescence, subcellular fractionation, Western blot, and overexpression migration assays in mammary epithelial and breast cancer lines

    PMID:29718989

    Open questions at the time
    • Mechanism targeting SGPL1 to the plasma membrane unknown
    • Whether plasma-membrane SGPL1 acts on extracellular vs. intracellular S1P pools not definitively separated

Open questions

Synthesis pass · forward-looking unresolved questions
  • How SGPL1-regulated S1P levels intersect with specific S1P receptors and pro-survival kinase signaling (Akt/Erk) across tissues remains to be defined mechanistically.
  • Direct enzymatic characterization absent in tumor-context studies
  • Receptor- and kinase-level coupling inferred from expression/pathway readouts rather than direct tests

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0016829 lyase activity 2 GO:0016787 hydrolase activity 1
Localization
GO:0005783 endoplasmic reticulum 1 GO:0005829 cytosol 1 GO:0005886 plasma membrane 1
Pathway
R-HSA-1430728 Metabolism 3 R-HSA-9612973 Autophagy 1

Evidence

Reading pass · 8 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2017 SGPL1 cleaves sphingosine-1-phosphate (S1P) into ethanolamine phosphate, which is directed toward phosphatidylethanolamine (PE) synthesis; PE anchors LC3-I to phagophore membranes as LC3-II, thereby supporting autophagy initiation in neurons. Neural-specific SGPL1 ablation reduced brain PE levels, decreased LC3-I→LC3-II conversion, increased BECN1/p62, accumulated unclosed phagophore-like structures, and impaired autophagic flux; addition of exogenous PE was sufficient to restore LC3-I→LC3-II conversion and normalize SQSTM1/APP/SNCA levels. Conditional neural knockout mouse (SGPL1fl/fl/Nes), pharmacological/genetic inhibition in cultured neurons, lipidomics (PE measurement), immunofluorescence and electron microscopy, EGFP-mRFP-LC3 flux reporter, PE rescue experiments Autophagy High 28521611
2021 Sgpl1 deletion in mice causes S1P accumulation in gonads. In the ovary, elevated S1P decreases natriuretic peptide receptor 2 (NPR2) activity in granulosa cells and inhibits early follicle growth. In the testis, elevated S1P increases p21 (cyclin-dependent kinase inhibitor 1A) levels and apoptosis in Leydig cells, resulting in spermatogenesis arrest. Thus SGPL1-mediated S1P degradation is required for germ cell development via distinct downstream pathways in each gonad. Sgpl1-knockout mice, gonadal S1P quantification, NPR2 activity assay in granulosa cells, p21 and apoptosis measurements in Leydig cells Cell death & disease Medium 34083520
2021 AAV9-mediated delivery of human SGPL1 to newborn Sgpl1-KO mice restored SGPL1 expression and enzymatic activity, reduced plasma and tissue sphingolipid levels (S1P, sphingosine, ceramide), prevented nephrosis, neurodevelopmental delay, anemia, and hypercholesterolemia, and attenuated renal STAT3 pathway activation and pro-inflammatory/pro-fibrogenic cytokines, demonstrating that SGPL1 enzymatic activity is the root cause of the multi-systemic SPLIS phenotype. AAV9 gene transfer in Sgpl1-KO mouse model, survival analysis, sphingolipid mass spectrometry, histopathology, cytokine profiling, STAT3 pathway analysis JCI insight High 33755599
2020 SGPL1 deficiency (patient-derived fibroblasts and CRISPR-engineered SGPL1-KO HeLa cells) is associated with accumulation of S1P, sphingosine, ceramide, and sphingomyelin, reduced total mitochondrial volume, and altered mitochondrial dynamics and oxidative phosphorylation parameters, indicating that S1P lyase activity is required for normal mitochondrial morphology and function. Patient-derived dermal fibroblasts, CRISPR-KO HeLa cells, mass spectrometry for sphingolipids, mitochondrial morphology imaging, oxidative phosphorylation assays, cortisol output assay The Journal of steroid biochemistry and molecular biology Medium 32682944
2018 SGPL1 protein is expressed not only in the endoplasmic reticulum/cytoplasm but also at the plasma membrane of non-tumorigenic mammary epithelial cells. Loss of this plasma membrane localization in breast cancer cell lines (MCF-7, BT-20) coincides with reduced SGPL1 expression and enhanced S1P-dependent cell migration. Overexpression of the natural SGPL1 variant suppressed both S1P-stimulated and general migratory activity, functionally linking plasma membrane SGPL1 to extracellular S1P degradation and migration control. Immunofluorescence, subcellular fractionation, Western blot, migration/invasion assays, SGPL1 overexpression in breast cancer cell lines PloS one Medium 29718989
2016 In oral squamous cell carcinoma (OSCC) cells, S1P signaling (regulated by SPHK1 and SGPL1) promotes cell migration/invasion and attenuates cisplatin-induced death. S1P-induced migration of OSCC cells is mediated in part through S1PR2 overexpression. FTY720, which depletes functional S1P receptors, induced apoptosis in OSCC cells and synergized with cisplatin, placing SGPL1-regulated S1P levels upstream of S1PR2-driven migration. In vitro migration/invasion assays, siRNA knockdown, S1PR2 overexpression, apoptosis assays, drug combination studies in OSCC cell lines Scientific reports Low 27160553
2022 SGPL1 overexpression in steatotic HHL-5 hepatocytes abolished the anti-apoptotic effect of ginsenoside Rg1, downregulated Bcl-2, p-Akt, and p-Erk1/2, and upregulated Bax, demonstrating that SGPL1 activity suppresses pro-survival signaling (Akt and Erk1/2 pathways) in fatty liver cells, likely through S1P degradation. SGPL1 overexpression in HHL-5 hepatocytes, apoptosis assays, Western blot for Bcl-2/Bax/p-Akt/p-Erk1/2, lipid accumulation assays Molecular medicine reports Low 35322862
2017 Genistein + calcitriol combination treatment of MG-63 osteosarcoma cells upregulated SGPL1 expression by ~350%, leading to increased ethanolamine metabolite levels (consistent with S1P cleavage) and suppression of cancer cell migration, linking SGPL1 enzymatic activity to anti-metastatic effects via S1P degradation. GC/MS metabolomics, qPCR, Western blot for SGPL1, cell proliferation and migration assays in osteosarcoma cell lines PloS one Low 28125641

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2015 The miR156/SPL Module, a Regulatory Hub and Versatile Toolbox, Gears up Crops for Enhanced Agronomic Traits. Molecular plant 242 25617719
2002 Hairy/E(spl)-related (Her) genes are central components of the segmentation oscillator and display redundancy with the Delta/Notch signaling pathway in the formation of anterior segmental boundaries in the zebrafish. Development (Cambridge, England) 226 12050140
2001 HERP, a novel heterodimer partner of HES/E(spl) in Notch signaling. Molecular and cellular biology 187 11486045
1992 The Enhancer of split [E(spl)] locus of Drosophila encodes seven independent helix-loop-helix proteins. Proceedings of the National Academy of Sciences of the United States of America 187 1528887
1987 cDNA and deduced amino acid sequence of human pulmonary surfactant-associated proteolipid SPL(Phe). Proceedings of the National Academy of Sciences of the United States of America 183 3035561
2013 Functional Evolution in the Plant SQUAMOSA-PROMOTER BINDING PROTEIN-LIKE (SPL) Gene Family. Frontiers in plant science 177 23577017
1996 Functional relationships between Notch, Su(H) and the bHLH genes of the E(spl) complex: the E(spl) genes mediate only a subset of Notch activities during imaginal development. Development (Cambridge, England) 163 8787746
2020 The miR156/SPL module regulates apple salt stress tolerance by activating MdWRKY100 expression. Plant biotechnology journal 161 32885918
1999 her4, a zebrafish homologue of the Drosophila neurogenic gene E(spl), is a target of NOTCH signalling. Development (Cambridge, England) 160 10101116
2014 microRNA156-targeted SPL/SBP box transcription factors regulate tomato ovary and fruit development. The Plant journal : for cell and molecular biology 142 24580734
1988 cDNA, deduced polypeptide structure and chromosomal assignment of human pulmonary surfactant proteolipid, SPL(pVal). The Journal of biological chemistry 121 3335510
2020 MiR156 regulates anthocyanin biosynthesis through SPL targets and other microRNAs in poplar. Horticulture research 100 32821401
2017 SGPL1 (sphingosine phosphate lyase 1) modulates neuronal autophagy via phosphatidylethanolamine production. Autophagy 91 28521611
2020 Characterizing the Role of the miR156-SPL Network in Plant Development and Stress Response. Plants (Basel, Switzerland) 85 32942558
2018 miR156-SPL modules regulate induction of somatic embryogenesis in citrus callus. Journal of experimental botany 67 29659948
2003 Two modes of recruitment of E(spl) repressors onto target genes. Development (Cambridge, England) 66 12466194
2014 Molecular characterization of the SPL gene family in Populus trichocarpa. BMC plant biology 65 24884654
2016 The Spl Serine Proteases Modulate Staphylococcus aureus Protein Production and Virulence in a Rabbit Model of Pneumonia. mSphere 64 27747296
2017 Response of miR156-SPL Module during the Red Peel Coloration of Bagging-Treated Chinese Sand Pear (Pyrus pyrifolia Nakai). Frontiers in physiology 62 28824447
2013 Genome-wide analysis and molecular dissection of the SPL gene family in Salvia miltiorrhiza. Journal of integrative plant biology 60 24112769
2020 Genome-wide identification, phylogeny and expression analysis of the SPL gene family in wheat. BMC plant biology 59 32912142
1993 Molecular cloning and characterization of the Bacillus subtilis spore photoproduct lyase (spl) gene, which is involved in repair of UV radiation-induced DNA damage during spore germination. Journal of bacteriology 59 8449881
2018 Exploiting SPL genes to improve maize plant architecture tailored for high-density planting. Journal of experimental botany 58 29992284
2018 Genome-wide analysis of the SPL/miR156 module and its interaction with the AP2/miR172 unit in barley. Scientific reports 57 29728569
2004 her3, a zebrafish member of the hairy-E(spl) family, is repressed by Notch signalling. Development (Cambridge, England) 51 15169758
1995 Suppressor of hairless, the Drosophila homologue of RBP-J kappa, transactivates the neurogenic gene E(spl)m8. Idengaku zasshi 50 7546844
2013 Transcriptional dynamics elicited by a short pulse of notch activation involves feed-forward regulation by E(spl)/Hes genes. PLoS genetics 46 23300480
2005 Inhibition of neurogenesis at the zebrafish midbrain-hindbrain boundary by the combined and dose-dependent activity of a new hairy/E(spl) gene pair. Development (Cambridge, England) 45 15590746
1999 Ectopic expression of individual E(spl) genes has differential effects on different cell fate decisions and underscores the biphasic requirement for notch activity in wing margin establishment in Drosophila. Development (Cambridge, England) 43 10207145
2017 MicroRNA 157-targeted SPL genes regulate floral organ size and ovule production in cotton. BMC plant biology 42 28068913
2006 Functional and structural characterization of Spl proteases from Staphylococcus aureus. Journal of molecular biology 42 16516230
2015 Molecular characterization of SQUAMOSA PROMOTER BINDING PROTEIN-LIKE (SPL) gene family from Citrus and the effect of fruit load on their expression. Frontiers in plant science 41 26074947
2007 Completing the set of h/E(spl) cyclic genes in zebrafish: her12 and her15 reveal novel modes of expression and contribute to the segmentation clock. Developmental biology 41 17274976
2019 Roles of the SPL gene family and miR156 in the salt stress responses of tamarisk (Tamarix chinensis). BMC plant biology 38 31438851
2016 Aberrant expression of the S1P regulating enzymes, SPHK1 and SGPL1, contributes to a migratory phenotype in OSCC mediated through S1PR2. Scientific reports 38 27160553
2007 Identification of neural progenitor pools by E(Spl) factors in the embryonic and adult brain. Brain research bulletin 37 18331883
2016 Trichome patterning control involves TTG1 interaction with SPL transcription factors. Plant molecular biology 36 27631431
1993 Drosophila evolution challenges postulated redundancy in the E(spl) gene complex. Proceedings of the National Academy of Sciences of the United States of America 36 8516287
2018 Genome-wide identification and characterization of SPL transcription factor family and their evolution and expression profiling analysis in cotton. Scientific reports 35 29335584
2021 Involvement of the miR156/SPL module in flooding response in Medicago sativa. Scientific reports 34 33547346
2019 Genome-wide identification of the SPL gene family in Tartary Buckwheat (Fagopyrum tataricum) and expression analysis during fruit development stages. BMC plant biology 34 31286919
2014 Genomic organization, differential expression, and functional analysis of the SPL gene family in Gossypium hirsutum. Molecular genetics and genomics : MGG 34 25159110
2017 Nephrotic syndrome and adrenal insufficiency caused by a variant in SGPL1. Clinical kidney journal 33 30090628
2020 Molecular and functional characterization of the SBP-box transcription factor SPL-CNR in tomato fruit ripening and cell death. Journal of experimental botany 32 32016417
2018 Molecular Characterization of SQUAMOSA PROMOTER BINDING PROTEIN-LIKE (SPL) Gene Family in Betula luminifera. Frontiers in plant science 32 29780401
2019 Roles of the GA-mediated SPL Gene Family and miR156 in the Floral Development of Chinese Chestnut (Castanea mollissima). International journal of molecular sciences 30 30934840
2022 Low-affinity SPL binding sites contribute to subgenome expression divergence in allohexaploid wheat. Science China. Life sciences 29 36417050
2016 Control of Neural Daughter Cell Proliferation by Multi-level Notch/Su(H)/E(spl)-HLH Signaling. PLoS genetics 29 27070787
2015 Effect of SPL (Spent Pot Liner) and its main components on root growth, mitotic activity and phosphorylation of Histone H3 in Lactuca sativa L. Ecotoxicology and environmental safety 29 26615478
2011 Spent Pot Liner (SPL) induced DNA damage and nuclear alterations in root tip cells of Allium cepa as a consequence of programmed cell death. Ecotoxicology and environmental safety 29 21232797
2019 SGPL1 Deficiency: A Rare Cause of Primary Adrenal Insufficiency. The Journal of clinical endocrinology and metabolism 28 30517686
2015 Paralogous SQUAMOSA PROMOTER BINDING PROTEIN-LIKE (SPL) genes differentially regulate leaf initiation and reproductive phase change in petunia. Planta 27 26445769
2023 Meristem dormancy in Marchantia polymorpha is regulated by a liverwort-specific miRNA and a clade III SPL gene. Current biology : CB 26 36696899
2021 Efficacy of AAV9-mediated SGPL1 gene transfer in a mouse model of S1P lyase insufficiency syndrome. JCI insight 26 33755599
2020 Genome-wide characterization of the SPL gene family involved in the age development of Jatropha curcas. BMC genomics 26 32434522
2018 Characterization of Vv-miR156: Vv-SPL pairs involved in the modulation of grape berry development and ripening. Molecular genetics and genomics : MGG 26 29943289
1996 Distinct phosphate backbone contacts revealed by some mutant peptides of zinc finger protein Spl: effect of protein-induced bending on DNA recognition. Biochemistry 26 8679640
2022 The miR157-SPL-CNR module acts upstream of bHLH101 to negatively regulate iron deficiency responses in tomato. Journal of integrative plant biology 25 35297168
2019 Genome-wide characterization of SPL family in Medicago truncatula reveals the novel roles of miR156/SPL module in spiky pod development. BMC genomics 25 31277566
2019 Regulation of Notch output dynamics via specific E(spl)-HLH factors during bristle patterning in Drosophila. Nature communications 24 31375669
2017 Genome-wide identification and characterization of the SPL gene family in Ziziphus jujuba. Gene 24 28652183
2014 E(spl): genetic, developmental, and evolutionary aspects of a group of invertebrate Hes proteins with close ties to Notch signaling. Current topics in developmental biology 24 25248478
2021 Intra-articular injection of loaded sPL sustained-release microspheres inhibits osteoarthritis and promotes cartilaginous repairs. Journal of orthopaedic surgery and research 23 34717689
2004 Drosophila CK2 regulates eye morphogenesis via phosphorylation of E(spl)M8. Mechanisms of development 23 15003630
1990 Defective ommatidial cell assembly leads to defective morphogenesis: a phenotypic analysis of the E(spl) D mutation of Drosophila melanogaster. Roux's archives of developmental biology : the official organ of the EDBO 23 28305667
2020 Sphingosine-1-phosphate lyase (SGPL1) deficiency is associated with mitochondrial dysfunction. The Journal of steroid biochemistry and molecular biology 22 32682944
2018 First evidence of SGPL1 expression in the cell membrane silencing the extracellular S1P siren in mammary epithelial cells. PloS one 22 29718989
2022 Conservation and Divergence of SQUAMOSA-PROMOTER BINDING PROTEIN-LIKE (SPL) Gene Family between Wheat and Rice. International journal of molecular sciences 21 35216210
2022 Genome-wide identification and characterization of the SPL gene family and its expression in the various developmental stages and stress conditions in foxtail millet (Setaria italica). BMC genomics 21 35596144
2022 Genome-wide identification and expression analysis of the SPL transcription factor family and its response to abiotic stress in Quinoa (Chenopodium quinoa). BMC genomics 21 36434504
2019 Characterization and Rapid Gene-Mapping of Leaf Lesion Mimic Phenotype of spl-1 Mutant in Soybean (Glycine max (L.) Merr.). International journal of molecular sciences 21 31058828
2023 Molecular characterization of SPL gene family during flower morphogenesis and regulation in blueberry. BMC plant biology 20 36650432
1999 Overexpression of the m4 and malpha genes of the E(spl)-complex antagonizes notch mediated lateral inhibition. Mechanisms of development 20 10446264
2023 The SPL transcription factor TaSPL6 negatively regulates drought stress response in wheat. Plant physiology and biochemistry : PPB 19 38091935
2019 Comparative genome analysis of the SPL gene family reveals novel evolutionary features in maize. Genetics and molecular biology 19 31271590
1995 A Drosophila E(spł) gene is "neurogenic" in Xenopus: a green fluorescent protein study. Developmental biology 19 7729602
2023 Identification of Alfalfa SPL gene family and expression analysis under biotic and abiotic stresses. Scientific reports 18 36596810
2019 Expression Pattern of FT/TFL1 and miR156-Targeted SPL Genes Associated with Developmental Stages in Dendrobium catenatum. International journal of molecular sciences 18 31163611
2018 Notch Target Gene E(spl)mδ Is a Mediator of Methylmercury-Induced Myotoxicity in Drosophila. Frontiers in genetics 18 29379520
2018 Genome-wide identification and expression analysis of the SPL gene family in woodland strawberry Fragaria vesca. Genome 18 30067072
2014 The Notch target E(spl)mδ is a muscle-specific gene involved in methylmercury toxicity in motor neuron development. Neurotoxicology and teratology 18 24632433
2022 Ginsenoside Rg1 exerts anti‑apoptotic effects on non‑alcoholic fatty liver cells by downregulating the expression of SGPL1. Molecular medicine reports 17 35322862
2021 Genome-wide identification, gene cloning, subcellular location and expression analysis of SPL gene family in P. granatum L. BMC plant biology 17 34454435
2022 Genome-wide analysis and molecular dissection of the SPL gene family in Fraxinus mandshurica. BMC plant biology 16 36127640
2000 Barbu: an E(spl) m4/m(alpha)-related gene that antagonizes Notch signaling and is required for the establishment of ommatidial polarity. Development (Cambridge, England) 16 10662650
2023 Genome-Wide Identification of the SQUAMOSA Promoter-Binding Protein-like (SPL) Transcription Factor Family in Sweet Cherry Fruit. International journal of molecular sciences 15 36769201
2021 Sgpl1 deletion elevates S1P levels, contributing to NPR2 inactivity and p21 expression that block germ cell development. Cell death & disease 15 34083520
2017 Synergistic Action of Genistein and Calcitriol in Immature Osteosarcoma MG-63 Cells by SGPL1 Up-Regulation. PloS one 14 28125641
2014 The transcription factor hairy/E(spl)-related 2 induces proliferation of neural progenitors and regulates neurogenesis and gliogenesis. Developmental biology 14 25446033
1999 Enhancer of split [E(spl)(D)] is a gro-independent, hypermorphic mutation in Drosophila. Developmental genetics 14 10440851
2024 Genome-wide identification, evolution, and role of SPL gene family in beet (Beta vulgaris L.) under cold stress. BMC genomics 13 38262939
2022 A rare cause of nephrotic syndrome-sphingosine-1-phosphate lyase (SGPL1) deficiency: 6 cases and a review of the literature. Pediatric nephrology (Berlin, Germany) 13 35748945
2015 Deltex1 is inhibited by the Notch-Hairy/E(Spl) signaling pathway and induces neuronal and glial differentiation. Neural development 13 26714454
2013 The two Tribolium E(spl) genes show evolutionarily conserved expression and function during embryonic neurogenesis. Mechanisms of development 13 23485410
2011 Mechanistic studies of the radical SAM enzyme spore photoproduct lyase (SPL). Biochimica et biophysica acta 13 22197590
2021 Genome-wide identification, phylogenetic analysis, and expression analysis of the SPL gene family in orchardgrass (Dactylis glomerata L.). Genomics 12 34058273
2012 The bHLH factors Dpn and members of the E(spl) complex mediate the function of Notch signalling regulating cell proliferation during wing disc development. Biology open 12 23213460
2022 Genome-wide identification, phylogeny and expression analysis of the SPL gene family and its important role in salt stress in Medicago sativa L. BMC plant biology 11 35705909
2022 Comprehensive analyses of the SPL transcription factor family in Paulownia fortunei and their responses to biotic and abiotic stresses. International journal of biological macromolecules 11 36442550
2021 Characterization and expression analysis of the SPL gene family during floral development and abiotic stress in pecan (Carya illinoinensis). PeerJ 11 34966577

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