Affinage

MBOAT7

Membrane-bound acylglycerophosphatidylinositol O-acyltransferase MBOAT7 · UniProt Q96N66

Length
472 aa
Mass
52.8 kDa
Annotated
2026-04-28
100 papers in source corpus 19 papers cited in narrative 19 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

MBOAT7 (LPIAT1) is an integral endomembrane acyltransferase that selectively transfers arachidonic acid from arachidonoyl-CoA onto lysophosphatidylinositol to generate AA-enriched phosphatidylinositol, thereby maintaining the acyl-chain composition of PI and PI phosphates via the Lands cycle (PMID:23097495, PMID:33513444, PMID:37316513). Its six-transmembrane topology positions the catalytic dyad (Asn-321/His-356) on the lumenal side, where arachidonyl-CoA and lyso-PI access the active site through a twisted tunnel, and N-terminal lumenal residues determine headgroup selectivity; MBOAT7 operates within a Golgi-localized MMD–ACSL4–MBOAT7 complex that channels arachidonic acid into PI (PMID:30959108, PMID:37316513, PMID:37691145). Loss of MBOAT7 activity accumulates lysophosphatidylinositol and depletes AA-PI, triggering SREBP-1c–driven de novo lipogenesis and PLC/DAG-mediated triglyceride synthesis in hepatocytes, a TAZ/IHH profibrotic axis, impaired TFEB-dependent lysosomal biogenesis, redistribution of arachidonic acid toward proinflammatory eicosanoids in macrophages, and adipose insulin resistance—collectively driving NAFLD/MASH, alcohol-associated liver disease, and metabolic dysfunction (PMID:32859645, PMID:32253259, PMID:38776184, PMID:38648183, PMID:36473860, PMID:36806709). Homozygous inactivating MBOAT7 variants cause autosomal recessive intellectual disability with epilepsy and autistic features, reflecting a requirement for AA-containing PI in cortical neuronal migration (PMID:27616480, PMID:23097495).

Mechanistic history

Synthesis pass · year-by-year structured walk · 11 steps
  1. 2012 High

    Establishing that MBOAT7/LPIAT1 is the non-redundant lysophosphatidylinositol acyltransferase that incorporates arachidonic acid into PI, and that its absence disrupts brain PI composition, cortical lamination, and neuronal migration

    Evidence Lpiat1 knockout mice with lipidomics, histology, and neurite outgrowth assays

    PMID:23097495

    Open questions at the time
    • Catalytic mechanism and substrate specificity not biochemically defined
    • Whether brain phenotype reflects PI or PIP2 depletion unresolved
    • Role in non-neural tissues not explored
  2. 2013 High

    Demonstrating that MBOAT7 loss reduces not only PI but also PIP2 species and elevates lyso-PI in both brain and liver, establishing a broader role in phosphoinositide homeostasis

    Evidence Lpiat1 KO mouse tissues analyzed by LC-ESI/MS lipidomics

    PMID:23472195

    Open questions at the time
    • Liver functional consequences of altered PI not yet studied
    • Whether lyso-PI itself has signaling properties unknown
  3. 2016 High

    Linking the common MBOAT7 rs641738 variant to reduced hepatic MBOAT7 expression and altered plasma PI species in humans, connecting the enzyme to human liver disease susceptibility; simultaneously, rare biallelic MBOAT7 loss-of-function variants were shown to cause autosomal recessive intellectual disability with epilepsy

    Evidence Human cohort genotyping with hepatic protein/plasma lipidomics; whole-exome sequencing in six consanguineous families

    PMID:26850495 PMID:27616480

    Open questions at the time
    • Mechanism linking reduced MBOAT7 to steatosis/fibrosis not defined
    • No animal model recapitulating rs641738 partial loss
  4. 2019 High

    Resolving MBOAT7 membrane topology—six transmembrane domains with a lumenally oriented catalytic dyad—and showing that Mboat7 loss is sufficient to promote NAFLD progression, with accumulated lyso-PI acting as a causal lipotoxic mediator

    Evidence Fluorescence protease protection and selective permeabilization in cells; Mboat7 KO and ASO knockdown mice with direct LPI administration

    PMID:30959108 PMID:31621579

    Open questions at the time
    • High-resolution structure not yet available
    • Downstream signaling pathways from lyso-PI not mapped
  5. 2020 High

    Elucidating hepatocyte-autonomous mechanisms: MBOAT7 loss drives steatosis via both SREBP-1c activation (requiring Scap) and a PLC/DAG pathway that directly fuels triglyceride synthesis from PI breakdown; insulin signaling represses MBOAT7 expression, with FATP1 upregulation as a rescuable effector

    Evidence Hepatocyte-specific KO, Scap/Mboat7 double KO epistasis, isotope-tracing in hepatocytes and liver spheroids, FATP1 genetic rescue

    PMID:32058943 PMID:32253259 PMID:32591434 PMID:32859645

    Open questions at the time
    • Relative contribution of SREBP-1c vs. PLC/DAG pathway not quantified
    • Whether insulin-mediated downregulation operates transcriptionally or post-transcriptionally unclear
  6. 2020 High

    Demonstrating that MBOAT7-generated AA-PI pools are required for cancer cell proliferation, with ACSL3 acting upstream to channel arachidonic acid into PI for MBOAT7 remodeling

    Evidence CRISPR KO in ccRCC and lung cancer cells, in vivo tumor models, lipidomics

    PMID:32034305 PMID:32180553

    Open questions at the time
    • Whether pro-tumorigenic role is via eicosanoid generation, PI signaling, or ferroptosis sensitivity not resolved
    • Cancer-type specificity not established
  7. 2021 High

    Confirming MBOAT7 substrate preference for 20:4/20:5 PUFAs and the essentiality of the Asn-321/His-356 catalytic dyad through in vitro reconstitution with purified enzyme

    Evidence Recombinant MBOAT7 and site-directed mutants expressed in Pichia pastoris, radiolabeled acyltransferase assays

    PMID:33513444

    Open questions at the time
    • Structural basis for PUFA selectivity unknown
    • Kinetic parameters not fully determined
  8. 2022 High

    Revealing that MBOAT7 is a negative regulator of TLR signaling in macrophages: its deficiency redistributes arachidonic acid toward proinflammatory eicosanoids, induces ER stress, and remodels chromatin accessibility at inflammatory loci

    Evidence MBOAT7 KO/KD in macrophages with lipidomics, eicosanoid profiling, ATAC-seq, gain-of-function rescue

    PMID:36473860

    Open questions at the time
    • Which specific eicosanoid species drive the phenotype not pinpointed
    • In vivo macrophage-specific KO not tested
  9. 2023 High

    High-resolution cryo-EM structure revealed the twisted tunnel architecture for dual substrate access and showed that lumenal N-terminal residues determine PI headgroup selectivity; simultaneously, the Golgi-resident MMD–ACSL4–MBOAT7 complex was defined as a functional unit channeling AA into PI and sensitizing cells to ferroptosis

    Evidence Cryo-EM structure with domain-swap mutagenesis; reciprocal co-IP and genetic epistasis with ferroptosis assays

    PMID:37316513 PMID:37691145

    Open questions at the time
    • Structure of the ternary MMD–ACSL4–MBOAT7 complex not resolved
    • Whether ferroptosis sensitization operates in hepatocytes in vivo unknown
  10. 2023 High

    Establishing a cell-autonomous metabolic role in adipocytes: adipocyte-specific MBOAT7 loss depletes AA-PI, promotes hyperinsulinemia and systemic insulin resistance independent of hepatocyte MBOAT7

    Evidence Adipocyte-specific Mboat7 KO mice with metabolic phenotyping and lipidomics

    PMID:36806709

    Open questions at the time
    • Signaling pathway from adipocyte PI depletion to insulin resistance not defined
    • Contribution to human metabolic syndrome unknown
  11. 2024 High

    Identifying downstream pathways of hepatocyte MBOAT7 loss in chronic liver disease: a cholesterol trafficking–TAZ–IHH profibrotic axis drives fibrosis in MASH, while impaired TFEB-mediated lysosomal biogenesis and autophagic flux exacerbate alcohol-associated liver injury

    Evidence Hepatocyte-specific MBOAT7 overexpression/silencing in MASH mice with human biopsy validation; hepatocyte-specific KO with ethanol feeding and autophagic flux/TFEB analysis

    PMID:38648183 PMID:38776184

    Open questions at the time
    • How altered PI composition mechanistically activates TAZ not resolved
    • Whether lysosomal defects and TAZ activation represent parallel or sequential pathways unknown

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key open questions include the structural basis of the MMD–ACSL4–MBOAT7 ternary complex, the precise lipid signaling intermediate linking PI depletion to SREBP-1c processing, the mechanism by which altered PI composition disrupts lysosomal biogenesis and TFEB activity, and whether pharmacological MBOAT7 activation can reverse established liver fibrosis in humans
  • No ternary complex structure available
  • Lipid intermediate between PI depletion and SREBP-1c unknown
  • No clinical intervention data

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0016740 transferase activity 5 GO:0008289 lipid binding 3
Localization
GO:0005783 endoplasmic reticulum 2 GO:0005794 Golgi apparatus 1
Pathway
R-HSA-1430728 Metabolism 6 R-HSA-1643685 Disease 4 R-HSA-162582 Signal Transduction 2 R-HSA-168256 Immune System 1 R-HSA-5357801 Programmed Cell Death 1 R-HSA-9612973 Autophagy 1
Partners
ACSL3ACSL4FATP1MMD
Complex memberships
MMD-ACSL4-MBOAT7

Evidence

Reading pass · 19 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2012 LPIAT1/MBOAT7 is a lysophosphatidylinositol acyltransferase that selectively incorporates arachidonic acid (AA) into phosphatidylinositol (PI). Lpiat1 knockout mice show almost no LPIAT activity with arachidonoyl-CoA as acyl donor, reduced AA content in PI and PI phosphates, and die within a month with atrophy of the cerebral cortex and hippocampus, disordered cortical lamination, delayed neuronal migration, and reduced neurite outgrowth in vitro. Mouse knockout (Lpiat1-/-), lipid mass spectrometry, immunohistochemistry, in vitro neurite outgrowth assay Molecular biology of the cell High 23097495
2013 LPIAT1/MBOAT7 plays a non-redundant role in maintaining physiological levels of PtdIns and PtdInsP2 through an active deacylation/reacylation cycle. LPIAT1 knockout mice show reduced C38:4 PtdIns and PtdInsP2 (26-44% reduction) and markedly elevated C18:0 lyso-PtdIns in both brain and liver, confirming a substrate-specific reacylation function. Mouse knockout (LPIAT1-/-), LC-ESI/MS lipidomics of brain and liver PloS one High 23472195
2016 The MBOAT7 rs641738 T risk allele is associated with reduced MBOAT7 protein expression in the liver and changes in plasma phosphatidylinositol species consistent with decreased MBOAT7 acyltransferase function, linking the variant to impaired hepatic phosphatidylinositol acyl-chain remodeling. Human cohort genotyping, hepatic protein expression measurement, plasma lipidomics Gastroenterology Medium 26850495
2016 Homozygous inactivating variants in MBOAT7 (encoding LPIAT1, a membrane-bound phospholipid-remodeling enzyme that transfers arachidonic acid to lysophosphatidylinositol) cause autosomal recessive intellectual disability accompanied by epilepsy and autistic features, establishing a direct role for AA-containing phosphatidylinositols in brain development. Human genetics (whole-exome sequencing, Sanger sequencing) in six consanguineous families American journal of human genetics High 27616480
2019 MBOAT7 is an integral membrane protein anchored to endomembranes by six transmembrane domains. Its predicted catalytic dyad—Asn-321 and His-356—faces the lumen of endomembranes, consistent with acylation of lysophospholipid substrates on the lumenal side. Membrane fractionation, in silico topology prediction, GFP/FLAG-tagged truncation constructs in live cells, co-immunofluorescence, fluorescence protease protection (FPP) assay, selective membrane permeabilization Journal of structural biology High 30959108
2019 Mboat7 loss of function (but not Tmc4 loss) in mice is sufficient to promote NAFLD progression under high-fat diet. Mboat7 loss is associated with accumulation of its substrate lysophosphatidylinositol (LPI), and direct LPI administration promotes hepatic inflammatory and fibrotic transcriptional changes in an Mboat7-dependent manner, establishing the MBOAT7-driven acylation of LPI as a suppressor of NAFLD progression. Mouse whole-body knockout, antisense oligonucleotide knockdown, direct LPI administration, hepatic gene expression, histology eLife High 31621579
2020 Hepatocyte-specific deletion of Mboat7 in mice causes spontaneous hepatic steatosis (increased cholesterol ester content) and increased fibrosis on high-fat diet, with accumulation of lysophosphatidylinositol species, via an inflammation-independent pathway of liver fibrosis mediated by lipid signaling. Hepatocyte-specific Mboat7 knockout mouse (Mboat7Δhep), histology (picrosirius red, hydroxyproline), flow cytometry, RNA-seq, lipidomics of mouse and human biopsies Gut High 32591434
2020 MBOAT7 depletion in hepatocytes increases triglyceride synthesis via a non-canonical pathway: reduced PI acyl-chain remodeling causes high PI turnover (simultaneous stimulation of PI synthesis and breakdown), and PI degradation by phospholipase C produces diacylglycerol (DAG), a triglyceride precursor, directly fueling hepatic fat accumulation. Hepatocyte-specific Lpiat1 KO mice, CRISPR-Cas9 and siRNA depletion in human hepatic cells and liver spheroids, radiolabeled glycerol/fatty acid flux, LC-ESI-MS lipidomics Gut High 32253259
2020 Hyperinsulinemia downregulates Mboat7 expression (via insulin signaling activation after refeeding), and acute Mboat7 silencing promotes hepatic steatosis in vivo by reducing arachidonic acid incorporation into PI, resulting in accumulation of saturated triglycerides, enhanced lipogenesis, and upregulation of fatty acid transporter FATP1; FATP1 deletion rescues the steatotic phenotype. Antisense oligonucleotide silencing in C57Bl/6 mice, CRISPR-Cas9 deletion in HepG2 cells, radiolabeled fatty acid incorporation assay, in vivo insulin treatment, FATP1 rescue experiment EBioMedicine High 32058943
2020 MBOAT7 deletion in clear cell renal cell carcinoma (ccRCC) cells decreases proliferation, induces cell cycle arrest, and prevents tumor formation in vivo; MBOAT7-/- RNAseq reveals alterations in cell migration and extracellular matrix organization, functionally validated in migration assays. ccRCC tumors accumulate arachidonic acid-enriched phosphatidylinositols (AA-PI) in an MBOAT7-dependent manner. Genome editing (CRISPR) in ccRCC cell lines, proliferation assays, in vivo tumor formation, RNA-seq, migration assays, shotgun lipidomics Molecular metabolism High 32180553
2020 ACSL3 channels arachidonic acid into phosphatidylinositols to provide LPIAT1/MBOAT7 with a pool of AA for sustained prostaglandin synthesis in lung cancer cells. LPIAT1 knockdown suppresses proliferation, anchorage-independent growth, and in vivo tumorigenesis in lung cancer, defining an ACSL3-LPIAT1 axis. Lung cancer cell line KD, KrasG12D mouse models, proliferation/colony assays, in vivo tumor models Oncogene High 32034305
2021 MBOAT7 (LPIAT1) preferentially transfers 20:4 (arachidonic acid) and 20:5 polyunsaturated fatty acids to lysophosphatidylinositol. Missense mutations at the putative catalytic dyad (N321A, H356A, and N321A+H356A double mutant) abolish O-acyltransferase activity, confirming these residues as essential for catalysis. Recombinant MBOAT7 and mutants expressed in Pichia pastoris, Ni-affinity purification, in vitro acyltransferase assay with radiolabeled fatty acids Biochimica et biophysica acta. Molecular and cell biology of lipids High 33513444
2021 Hepatic deletion of Mboat7 causes activation of SREBP-1c and de novo lipogenesis as the mechanism underlying fatty liver. Lipidomics showed selective reduction in 20-carbon PUFA-containing phosphatidylinositols but not other phospholipids. Dual deletion of Scap (required for SREBP processing) and Mboat7 normalized hepatic triglycerides, establishing that increased SREBP-1c processing is required for Mboat7-induced steatosis. Liver-specific Mboat7 KO mice (Mboat7 LSKO), hepatic lipidomics by MS, dual Scap/Mboat7 liver KO genetic epistasis, gene expression analysis Journal of lipid research High 32859645
2022 MBOAT7 functions as a negative regulator of toll-like receptor (TLR) signaling in macrophages. MBOAT7 deficiency alters membrane phospholipid composition, redistributes arachidonic acid toward proinflammatory eicosanoids, induces ER stress and mitochondrial dysfunction, and remodels the accessible inflammatory chromatin landscape, culminating in exaggerated macrophage TLR responses. Activation of MBOAT7 reverses these effects. MBOAT7 KD/KO in macrophages, lipidomics, eicosanoid measurement, ER stress and mitochondrial function assays, chromatin accessibility (ATAC-seq), TLR stimulation assays Nature communications High 36473860
2023 Cryo-EM structure of human MBOAT7 reveals that arachidonyl-CoA and lyso-PI access the catalytic center through a twisted tunnel from the cytosol and lumenal sides, respectively. N-terminal residues on the ER lumenal side determine phospholipid headgroup selectivity: swapping N-terminal regions between MBOATs 1, 5, and 7 converts enzyme specificity for different lyso-phospholipid substrates. Structure-based virtual screening identified small-molecule inhibitors. Cryo-EM structure determination, domain-swap mutagenesis with acyltransferase activity assays, virtual screening Nature communications High 37316513
2023 Golgi-resident scaffold protein MMD physically interacts with both ACSL4 and MBOAT7 and promotes flux of arachidonic acid into phosphatidylinositol. MMD promotes ferroptosis susceptibility in ovarian and renal carcinoma cells in an ACSL4- and MBOAT7-dependent manner, identifying a MMD-ACSL4-MBOAT7 complex that increases AA-PI levels and pro-ferroptotic phospholipid peroxidation. Co-immunoprecipitation, genetic KO of MMD/ACSL4/MBOAT7, ferroptosis assays, lipidomics Cell reports High 37691145
2023 MBOAT7-driven lysophosphatidylinositol acylation in adipocytes is the major source of arachidonic acid-containing PI pools in adipose tissue. Adipocyte-specific Mboat7 KO promotes hyperinsulinemia, systemic insulin resistance, and mild fatty liver in mice fed high-fat/high-sucrose diet, demonstrating a cell-autonomous role in glucose homeostasis distinct from hepatocyte MBOAT7 function. Floxed Mboat7 mice crossed to adiponectin-Cre and albumin-Cre, metabolic phenotyping, adipose/hepatic lipidomics, panel of ~100 inbred mouse strains Journal of lipid research High 36806709
2024 Hepatocyte MBOAT7 loss promotes liver fibrosis via a cholesterol trafficking pathway that upregulates TAZ (WWTR1) and TAZ-induced profibrotic factor Indian hedgehog (IHH). MBOAT7 restoration in MASH mice lowers hepatocyte TAZ levels and slows fibrosis progression; MBOAT7 silencing in established steatohepatitis exacerbates fibrosis and increases nuclear TAZ and IHH mRNA, a finding validated in human MASH livers carrying the rs641738-T allele. Hepatocyte-specific MBOAT7 overexpression/silencing in MASH mice (AAV, ASO), TAZ/IHH protein and mRNA measurement, human liver biopsy TAZ immunostaining Hepatology High 38776184
2024 Hepatocyte-specific (but not myeloid-specific) deletion of Mboat7 exacerbates ethanol-induced liver injury. Mboat7-HSKO livers show reorganization of the hepatic lipidome with increased endosomal/lysosomal lipids, dysregulated autophagic flux, impaired TFEB-mediated lysosomal biogenesis, and autophagosome accumulation, revealing that MBOAT7 shapes lysosomal lipid homeostasis to control alcohol-associated liver disease. Hepatocyte-specific and myeloid-specific Mboat7 KO mice, ethanol feeding, lipidomics, autophagic flux assays, TFEB pathway analysis, flow cytometry eLife High 38648183

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1993 Activated T cells induce expression of B7/BB1 on normal or leukemic B cells through a CD40-dependent signal. The Journal of experimental medicine 541 7681471
2016 The MBOAT7-TMC4 Variant rs641738 Increases Risk of Nonalcoholic Fatty Liver Disease in Individuals of European Descent. Gastroenterology 526 26850495
1993 Induction of alloantigen-specific hyporesponsiveness in human T lymphocytes by blocking interaction of CD28 with its natural ligand B7/BB1. The Journal of experimental medicine 501 7678111
1991 The CD28 ligand B7/BB1 provides costimulatory signal for alloactivation of CD4+ T cells. The Journal of experimental medicine 390 1847724
1982 B lymphoblast antigen (BB-1) expressed on Epstein-Barr virus-activated B cell blasts, B lymphoblastoid cell lines, and Burkitt's lymphomas. Journal of immunology (Baltimore, Md. : 1950) 345 6274961
1992 Functional expression of the costimulatory molecule, B7/BB1, on murine dendritic cell populations. The Journal of experimental medicine 324 1328465
1992 The B7/BB1 antigen provides one of several costimulatory signals for the activation of CD4+ T lymphocytes by human blood dendritic cells in vitro. The Journal of clinical investigation 294 1378854
1993 Functional expression of B7/BB1 on activated T lymphocytes. The Journal of experimental medicine 283 7679711
1994 In vivo blockade of CD28/CTLA4: B7/BB1 interaction with CTLA4-Ig reduces lethal murine graft-versus-host disease across the major histocompatibility complex barrier in mice. Blood 228 7515723
2017 MBOAT7 rs641738 variant and hepatocellular carcinoma in non-cirrhotic individuals. Scientific reports 200 28674415
1994 T cell costimulation by B7/BB1 induces CD8 T cell-dependent tumor rejection: an important role of B7/BB1 in the induction, recruitment, and effector function of antitumor T cells. The Journal of experimental medicine 188 7511683
1992 Antibody and B7/BB1-mediated ligation of the CD28 receptor induces tyrosine phosphorylation in human T cells. The Journal of experimental medicine 144 1372649
2012 LPIAT1 regulates arachidonic acid content in phosphatidylinositol and is required for cortical lamination in mice. Molecular biology of the cell 123 23097495
1993 B7/BB1, the ligand for CD28, is expressed on repeatedly activated human T cells in vitro. European journal of immunology 123 7678229
1993 Discordant expression of CD28 ligands, BB-1, and B7 on keratinocytes in vitro and psoriatic cells in vivo. The American journal of pathology 117 7682758
1993 Expression and functional properties of mouse B7/BB1 using a fusion protein between mouse CTLA4 and human gamma 1. Immunology 106 8244464
2016 MBOAT7 rs641738 increases risk of liver inflammation and transition to fibrosis in chronic hepatitis C. Nature communications 105 27630043
2019 Obesity-linked suppression of membrane-bound O-acyltransferase 7 (MBOAT7) drives non-alcoholic fatty liver disease. eLife 104 31621579
2020 rs641738C>T near MBOAT7 is associated with liver fat, ALT and fibrosis in NAFLD: A meta-analysis. Journal of hepatology 103 32882372
1995 Abnormal expression of the E2 component of the pyruvate dehydrogenase complex on the luminal surface of biliary epithelium occurs before major histocompatibility complex class II and BB1/B7 expression. Hepatology (Baltimore, Md.) 102 7535733
2020 LPIAT1/MBOAT7 depletion increases triglyceride synthesis fueled by high phosphatidylinositol turnover. Gut 101 32253259
1999 Expression of the costimulatory molecule BB-1, the ligands CTLA-4 and CD28, and their mRNA in inflammatory myopathies. The American journal of pathology 97 10433938
2021 TM6SF2/PNPLA3/MBOAT7 Loss-of-Function Genetic Variants Impact on NAFLD Development and Progression Both in Patients and in In Vitro Models. Cellular and molecular gastroenterology and hepatology 88 34823063
2020 Loss of hepatic Mboat7 leads to liver fibrosis. Gut 87 32591434
1993 In situ expression of B7/BB1 on antigen-presenting cells and activated B cells: an immunohistochemical study. International immunology 79 7682106
1993 The B7/BB1 antigen is expressed by Reed-Sternberg cells of Hodgkin's disease and contributes to the stimulating capacity of Hodgkin's disease-derived cell lines. Blood 78 7693051
1993 Follicular dendritic cells help resting B cells to become effective antigen-presenting cells: induction of B7/BB1 and upregulation of major histocompatibility complex class II molecules. The Journal of experimental medicine 77 7504055
2016 Mutations in MBOAT7, Encoding Lysophosphatidylinositol Acyltransferase I, Lead to Intellectual Disability Accompanied by Epilepsy and Autistic Features. American journal of human genetics 71 27616480
2013 Lysophosphatidylinositol-acyltransferase-1 (LPIAT1) is required to maintain physiological levels of PtdIns and PtdInsP(2) in the mouse. PloS one 68 23472195
2020 Mboat7 down-regulation by hyper-insulinemia induces fat accumulation in hepatocytes. EBioMedicine 67 32058943
1993 CD28 ligation by monoclonal antibodies or B7/BB1 provides an accessory signal for the cyclosporin A-resistant generation of cytotoxic T cell activity. Journal of immunology (Baltimore, Md. : 1950) 64 7682237
1994 Elevated expression of CD80 (B7/BB1) and other accessory molecules on synovial fluid mononuclear cell subsets in rheumatoid arthritis. Arthritis and rheumatism 63 7526869
2006 Bombesin receptors as a novel anti-anxiety therapeutic target: BB1 receptor actions on anxiety through alterations of serotonin activity. The Journal of neuroscience : the official journal of the Society for Neuroscience 60 17035523
1995 Genetic and antigenic characterization of Babesia bovis merozoite spherical body protein Bb-1. Molecular and biochemical parasitology 59 7770080
1994 Expression of the B7/BB1 activation antigen and its ligand CD28 in T-cell-mediated skin diseases. The Journal of investigative dermatology 59 7523532
2000 Expression of the co-stimulatory molecule BB-1, the ligands CTLA-4 and CD28 and their mRNAs in chronic inflammatory demyelinating polyneuropathy. Brain : a journal of neurology 57 10908195
2020 MBOAT7 down-regulation by genetic and environmental factors predisposes to MAFLD. EBioMedicine 56 32629394
2005 Dihydroflavonol BB-1, an extract of natural plant Blumea balsamifera, abrogates TRAIL resistance in leukemia cells. Blood 54 16195335
2021 Hepatic deletion of Mboat7 (LPIAT1) causes activation of SREBP-1c and fatty liver. Journal of lipid research 48 32859645
1994 Expression of the costimulatory molecule B7/BB1 in autoimmune thyroid disease. The Quarterly journal of medicine 46 7516083
2019 MBOAT7 is anchored to endomembranes by six transmembrane domains. Journal of structural biology 44 30959108
2018 Lack of evidence supporting a role of TMC4-rs641738 missense variant-MBOAT7- intergenic downstream variant-in the Susceptibility to Nonalcoholic Fatty Liver Disease. Scientific reports 44 29572551
2023 MMD collaborates with ACSL4 and MBOAT7 to promote polyunsaturated phosphatidylinositol remodeling and susceptibility to ferroptosis. Cell reports 43 37691145
2018 The rs626283 Variant in the MBOAT7 Gene is Associated with Insulin Resistance and Fatty Liver in Caucasian Obese Youth. The American journal of gastroenterology 43 29485130
1993 Identification of two Th1 cell epitopes on the Babesia bovis-encoded 77-kilodalton merozoite protein (Bb-1) by use of truncated recombinant fusion proteins. Infection and immunity 41 7678098
2016 Association of MBOAT7 gene variant with plasma ALT levels in children: the PANIC study. Pediatric research 40 27411039
2020 The ACSL3-LPIAT1 signaling drives prostaglandin synthesis in non-small cell lung cancer. Oncogene 38 32034305
2022 A metabolic associated fatty liver disease risk variant in MBOAT7 regulates toll like receptor induced outcomes. Nature communications 37 36473860
1998 The BB1 monoclonal antibody recognizes both cell surface CD74 (MHC class II-associated invariant chain) as well as B7-1 (CD80), resolving the question regarding a third CD28/CTLA-4 counterreceptor. Journal of immunology (Baltimore, Md. : 1950) 35 9743327
2019 TM6SF2 and MBOAT7 Gene Variants in Liver Fibrosis and Cirrhosis. International journal of molecular sciences 33 30875804
2006 Identification of basogranulin (BB1) as a novel immunohistochemical marker of basophils in normal bone marrow and patients with myeloproliferative disorders. American journal of clinical pathology 30 16393678
1996 Lack of B7-1/BB1 and B7-2/B70 expression on thyrocytes of patients with Graves' disease. Delivery of costimulatory signals from bystander professional antigen-presenting cells. The Journal of clinical endocrinology and metabolism 30 8923872
1992 Induction of proliferative responses of T cells from Babesia bovis-immune cattle with a recombinant 77-kilodalton merozoite protein (Bb-1). Infection and immunity 30 1730498
2019 Meta-analysis of the association between MBOAT7 rs641738, TM6SF2 rs58542926 and nonalcoholic fatty liver disease susceptibility. Clinics and research in hepatology and gastroenterology 29 30824369
1996 Human keratinocytes constitutively express IL-4 receptor molecules and respond to IL-4 with an increase in B7/BB1 expression. Experimental dermatology 28 9028793
2011 Structure and activity of exo-1,3/1,4-β-glucanase from marine bacterium Pseudoalteromonas sp. BB1 showing a novel C-terminal domain. The FEBS journal 27 22129429
2022 Membrane-bound O-acyltransferase 7 (MBOAT7)-driven phosphatidylinositol remodeling in advanced liver disease. Journal of lipid research 26 35636492
2016 Phage-mediated horizontal gene transfer of both prophage and heterologous DNA by ϕBB-1, a bacteriophage of Borrelia burgdorferi. Pathogens and disease 26 27811049
2001 Mass, charge, and subcellular localization of a unique secretory product identified by the basophil-specific antibody BB1. The Journal of allergy and clinical immunology 25 11344351
1993 Interleukin-7 specifically induces the B7/BB1 antigen on human cord blood and peripheral blood T cells and T cell clones. International immunology 25 7690242
2021 LPIAT1/MBOAT7 contains a catalytic dyad transferring polyunsaturated fatty acids to lysophosphatidylinositol. Biochimica et biophysica acta. Molecular and cell biology of lipids 24 33513444
1995 Signal transduction by B7/BB1 expressed on activated T lymphocytes: cross-linking of B7/BB1 induces protein tyrosine phosphorylation and synergizes with signalling through T-cell receptor/CD3. Immunology 24 7490112
1994 B7/BB1 provides an important costimulatory signal for CD3-mediated T lymphocyte proliferation in patients with systemic lupus erythematosus (SLE). Clinical and experimental immunology 24 7512010
2020 Identification of novel loss of function variants in MBOAT7 resulting in intellectual disability. Genomics 21 32645526
2023 MBOAT7 in liver and extrahepatic diseases. Liver international : official journal of the International Association for the Study of the Liver 20 37605540
2021 PNPLA3, TM6SF2, and MBOAT7 Influence on Nutraceutical Therapy Response for Non-alcoholic Fatty Liver Disease: A Randomized Controlled Trial. Frontiers in medicine 20 34692725
2020 MBOAT7-driven phosphatidylinositol remodeling promotes the progression of clear cell renal carcinoma. Molecular metabolism 20 32180553
2019 Expanding the phenotype of phospholipid remodelling disease due to MBOAT7 gene defect. Journal of inherited metabolic disease 20 30701556
2019 Homozygous variants in the HEXB and MBOAT7 genes underlie neurological diseases in consanguineous families. BMC medical genetics 19 31852446
2018 Evidence for PTGER4, PSCA, and MBOAT7 as risk genes for gastric cancer on the genome and transcriptome level. Cancer medicine 18 30191681
2023 The structure of phosphatidylinositol remodeling MBOAT7 reveals its catalytic mechanism and enables inhibitor identification. Nature communications 17 37316513
2012 Selenium and zinc internalized by Lactobacillus buchneri Lb26 (DSM 16341) and Bifidobacterium lactis Bb1 (DSM 17850): improved bioavailability using a new biological approach. Journal of clinical gastroenterology 17 22955356
2019 Expanding the phenotypic spectrum of MBOAT7-related intellectual disability. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 16 31282596
2021 Association between MBOAT7 rs641738 polymorphism and non-alcoholic fatty liver in overweight or obese children. Nutrition, metabolism, and cardiovascular diseases : NMCD 15 33810963
2010 Discovery and characterization of a distinctive exo-1,3/1,4-{beta}-glucanase from the marine bacterium Pseudoalteromonas sp. strain BB1. Applied and environmental microbiology 15 20729316
2024 Low MBOAT7 expression, a genetic risk for MASH, promotes a profibrotic pathway involving hepatocyte TAZ upregulation. Hepatology (Baltimore, Md.) 14 38776184
2024 Characterization and genomic analysis of the Lyme disease spirochete bacteriophage ϕBB-1. PLoS pathogens 13 38558079
2018 Effect of MBOAT7 variant on hepatitis B and C infections in Moroccan patients. Scientific reports 13 30116012
1983 Studies on the B lymphoblast antigen No. 1 (BB-1) on a series of Burkitt lymphoma lines differing in the expression of the EBV/C3 receptor complex. Journal of immunology (Baltimore, Md. : 1950) 13 6187858
2023 MBOAT7-driven lysophosphatidylinositol acylation in adipocytes contributes to systemic glucose homeostasis. Journal of lipid research 12 36806709
2023 Enhancing Hepatic MBOAT7 Expression in Mice With Nonalcoholic Steatohepatitis. Gastro hep advances 12 37293574
2023 MBOAT7 rs641738 (C>T) is associated with NAFLD progression in men and decreased ASCVD risk in elder Chinese population. Frontiers in endocrinology 12 37424875
2022 Functional and Structural Changes in the Membrane-Bound O-Acyltransferase Family Member 7 (MBOAT7) Protein: The Pathomechanism of a Novel MBOAT7 Variant in Patients With Intellectual Disability. Frontiers in neurology 12 35509994
2020 A patient with novel MBOAT7 variant: The cerebellar atrophy is progressive and displays a peculiar neurometabolic profile. American journal of medical genetics. Part A 12 32744787
1996 Elevated in vivo expression of the costimulatory molecule B7-BB1 (CD80) on antigen presenting cells from a patient with SLE. Clinical and experimental rheumatology 12 8978970
2024 Membrane-bound O-acyltransferase 7 (MBOAT7) shapes lysosomal lipid homeostasis and function to control alcohol-associated liver injury. eLife 11 38648183
2021 The PNPLA3 rs738409 Variant but not MBOAT7 rs641738 is a Risk Factor for Nonalcoholic Fatty Liver Disease in Obese U.S. Children of Hispanic Ethnicity. Pediatric gastroenterology, hepatology & nutrition 11 34557398
2019 In Vitro Release of Bioactive Bone Morphogenetic Proteins (GDF5, BB-1, and BMP-2) from a PLGA Fiber-Reinforced, Brushite-Forming Calcium Phosphate Cement. Pharmaceutics 11 31484306
2022 A Seed-Borne Bacterium of Rice, Pantoea dispersa BB1, Protects Rice from the Seedling Rot Caused by the Bacterial Pathogen Burkholderia glumae. Life (Basel, Switzerland) 10 35743824
2020 The MBOAT7 rs641738 variant is associated with an improved outcome in primary sclerosing cholangitis. Clinics and research in hepatology and gastroenterology 10 31928970
2020 Phenotypic Characterization of Intellectual Disability Caused by MBOAT7 Mutation in Two Consanguineous Pakistani Families. Frontiers in pediatrics 10 33335874
1994 IL-7 induces surface expression of B7/BB1 on pre-B cells and an associated increase in their costimulatory effects on T cell proliferation. Cellular immunology 10 7507002
2017 The GDF5 mutant BB-1 enhances the bone formation induced by an injectable, poly(l-lactide-co-glycolide) acid (PLGA) fiber-reinforced, brushite-forming cement in a sheep defect model of lumbar osteopenia. The spine journal : official journal of the North American Spine Society 9 29031993
2021 Phomaligols F-I, polyoxygenated cyclohexenone derivatives from marine-derived fungus Aspergillus flavus BB1. Bioorganic chemistry 7 34426151
1996 Molecular analysis of a gene, BB1, overexpressed in bladder and breast carcinoma. Anticancer research 7 8702217
2024 Bifidobacterium bifidum Strain BB1 Inhibits Tumor Necrosis Factor-α-Induced Increase in Intestinal Epithelial Tight Junction Permeability via Toll-Like Receptor-2/Toll-Like Receptor-6 Receptor Complex-Dependent Stimulation of Peroxisome Proliferator-Activated Receptor γ and Suppression of NF-κB p65. The American journal of pathology 6 38885924
2023 Exome sequencing identifies homozygous variants in MBOAT7 associated with neurodevelopmental disorder. Clinical genetics 6 38088234
2002 Expression of the costimulatory molecule BB-1 and its receptors in patients with scleroderma-polymyositis overlap syndrome. Journal of the neurological sciences 6 12409186
2023 Liver Involvement in Patients with Rare MBOAT7 Variants and Intellectual Disability: A Case Report and Literature Review. Genes 5 37628684
2021 MBOAT7-TMC4 rs641738 Is Not Associated With the Risk of Hepatocellular Carcinoma or Persistent Hepatitis B Infection. Frontiers in oncology 5 34113561