Affinage

DGAT2

Diacylglycerol O-acyltransferase 2 · UniProt Q96PD7

Length
388 aa
Mass
43.8 kDa
Annotated
2026-06-09
97 papers in source corpus 24 papers cited in narrative 23 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 9/9 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

DGAT2 is an integral endoplasmic reticulum membrane enzyme that catalyzes the terminal, committed step of triacylglycerol synthesis, transferring a fatty acyl chain from acyl-CoA to diacylglycerol (PMID:11481335, PMID:11481333). It is a distinct gene family from DGAT1, with no sequence homology, and the two enzymes are functionally non-redundant: DGAT2-knockout mice are profoundly lipopenic and die postnatally from energy substrate deficiency and skin barrier failure, a phenotype DGAT1 cannot rescue (PMID:11481335, PMID:11481333, PMID:14668353). This non-redundancy is tissue- and product-specific — DGAT1 fully compensates in adipocytes (PMID:30936184) yet DGAT2 uniquely partitions newly synthesized TG into larger lipid droplets that are spared from ATGL-mediated lipolysis and beta-oxidation (PMID:37516308). DGAT2 resides in the ER under basal conditions and, upon lipid loading, redistributes to lipid droplet surfaces and mitochondria-associated membranes; an N-terminal positively charged mitochondrial targeting signal (residues 61–66) directs this localization (PMID:19049983). Recruitment to the lipid droplet surface requires DAG delivered by ATG2A and is promoted by the secretory GTPase Rab1b, coupling DGAT2 activity to lipid droplet expansion (PMID:38809969, PMID:41249819). DGAT2 functions within higher-order assemblies, forming homodimers and a ~650 kDa complex and channeling substrates by physically interacting with MGAT2 via its transmembrane domains and co-localizing with SCD1 (PMID:16751624, PMID:25164810). In the liver DGAT2 is the isoform tied to de novo lipogenic TG synthesis and to hepatic insulin resistance, and is regulated by signals including the MEK/ERK pathway, CTRP12, uPA/p38, and FAAH (PMID:17526931, PMID:20739640, PMID:32749667, PMID:25244504). A de novo DGAT2 missense mutation (p.Y223H) causes autosomal-dominant early-onset axonal Charcot-Marie-Tooth disease (PMID:26786738). The enzyme is selectively inhibitable by small molecules through a slowly reversible, noncompetitive two-step binding mechanism that depends on histidines H161 and H163 (PMID:30422629).

Mechanistic history

Synthesis pass · year-by-year structured walk · 13 steps
  1. 2001 High

    Established the core biochemical identity of DGAT2 as a diacylglycerol acyltransferase distinct from DGAT1, answering what reaction the gene product catalyzes.

    Evidence Heterologous expression in insect cells with in vitro acyltransferase assays and substrate specificity profiling

    PMID:11481333 PMID:11481335

    Open questions at the time
    • No structural basis for catalysis defined
    • Membrane topology and active-site residues not yet mapped
  2. 2003 High

    Demonstrated that DGAT2 is physiologically essential and non-redundant with DGAT1, resolving whether the two acyltransferases serve interchangeable roles.

    Evidence Constitutive Dgat2-knockout mice with lipid quantification and skin barrier assays

    PMID:14668353

    Open questions at the time
    • Tissue-specific contributions not dissected by global KO
    • Molecular basis for non-redundancy unexplained
  3. 2006 Medium

    Identified physical proximity between DGAT2 and SCD1, supporting substrate channeling of monounsaturated fatty acids into TG synthesis.

    Evidence Confocal co-localization, co-IP, and FRET in HeLa cells plus liver fractionation

    PMID:16751624

    Open questions at the time
    • Direct channeling of SCD1 product not biochemically demonstrated
    • Single-lab interaction data
  4. 2008 High

    Defined DGAT2 subcellular dynamics, showing basal ER residence and lipid-induced redistribution governed by an N-terminal mitochondrial targeting signal.

    Evidence Live-cell imaging, fractionation, and deletion mutagenesis with oleate loading

    PMID:19049983

    Open questions at the time
    • Trafficking machinery for LD/MAM redistribution not identified at the time
    • Functional consequence of MAM localization unclear
  5. 2007 High

    Linked hepatic DGAT2 specifically to lipogenic TG synthesis and insulin resistance, distinguishing it from DGAT1 in metabolic disease.

    Evidence Antisense oligonucleotide knockdown in diet-induced obese rats with hyperinsulinemic-euglycemic clamps

    PMID:17526931

    Open questions at the time
    • Mechanism connecting DGAT2 to SREBP1c regulation not resolved
    • Causal versus correlative role in insulin signaling not fully separated
  6. 2014 High

    Revealed DGAT2 quaternary organization and substrate-channeling partnership with MGAT2, explaining how the enzyme is embedded in a TG-synthesis assembly.

    Evidence Chemical cross-linking, co-IP, proximity ligation, and deletion mutagenesis identifying transmembrane-domain-mediated MGAT2 interaction

    PMID:25164810

    Open questions at the time
    • Composition of the full ~650 kDa complex not enumerated
    • Stoichiometry of DGAT2-MGAT2 interaction unknown
  7. 2018 High

    Defined the kinetic mechanism and key residues for pharmacological DGAT2 inhibition, enabling selective targeting.

    Evidence Enzyme kinetics, time-dependent inhibition, radioligand binding, and H161/H163 site-directed mutagenesis with imidazopyridine inhibitors

    PMID:30422629

    Open questions at the time
    • Whether H161/H163 are catalytic or purely inhibitor-binding residues not fully resolved
    • No co-crystal structure of inhibited enzyme
  8. 2018 High

    Separated the distinct contributions of DGAT1 and DGAT2 to hepatic VLDL assembly, showing DGAT2 supports particle number while DGAT1 drives full lipidation.

    Evidence Hepatocyte-specific DGAT1-KO mice with VLDL secretion assays, apoB quantification, EM, and isoform inhibitors

    PMID:30397187

    Open questions at the time
    • Spatial site of DGAT2-supplied TG for VLDL not pinpointed
    • Mechanism of compartmentalized TG pools unclear
  9. 2019 High

    Showed DGAT2 dispensability in adipocytes and its ability to rescue DGAT1-deficient intestinal LD formation, refining the tissue map of isoform compensation.

    Evidence Adipocyte-specific DGAT2-KO mice and DGAT2 overexpression rescue in patient-derived intestinal organoids

    PMID:30936184 PMID:31315900

    Open questions at the time
    • Determinants of tissue-specific compensation not defined
    • Why DGAT1 loss causes ER-stress lipotoxicity rescued by DGAT2 not mechanistically resolved
  10. 2023 Medium

    Established that DGAT2- versus DGAT1-generated TG enters functionally distinct lipid droplet pools with different lipolytic fates.

    Evidence Isoform-specific inhibitors in Huh7 cells with LD size analysis, ATGL co-localization, and fatty acid oxidation assays

    PMID:37516308

    Open questions at the time
    • Molecular basis for differential LD targeting unknown
    • Single-lab pharmacological discrimination
  11. 2024 Medium

    Identified Rab1b as a regulator of DGAT2 ER-to-LD redistribution and connected this trafficking to a human disease model.

    Evidence FRET with DGAT2/Rab1b activity mutants and analysis of TBC1D20-mutant fibroblasts

    PMID:38809969

    Open questions at the time
    • Direct Rab1b-DGAT2 physical contact not shown
    • How Rab1b activity controls DGAT2 movement mechanistically unclear
  12. 2025 High

    Defined the lipid-transfer mechanism recruiting DGAT2 to lipid droplets, showing ATG2A-delivered DAG is required for DGAT2 relocation and LD expansion.

    Evidence ATG2A loss-of-function, in vitro DAG-recruitment assay, LD imaging, and DGAT2 inhibitor experiments

    PMID:41249819

    Open questions at the time
    • Whether DAG binding directly anchors DGAT2 or acts via partners not fully resolved
    • Generalizability beyond the studied cell systems untested
  13. 2025 Medium

    Extended DGAT2 function to microglial lipid droplet formation in Alzheimer pathology, implicating it in amyloid-driven immune dysfunction.

    Evidence Pharmacological DGAT2 inhibition in vitro and in 5xFAD mice with lipidomics, phagocytosis assays, and plaque quantification

    PMID:40393454

    Open questions at the time
    • Direct enzymatic versus indirect contribution not separated
    • Off-target effects of inhibitor not fully excluded

Open questions

Synthesis pass · forward-looking unresolved questions
  • How DGAT2's distinct localization, substrate channeling, and lipid-droplet-product partitioning are integrated to produce a TG pool functionally separate from DGAT1 remains unresolved at the structural and mechanistic level.
  • No high-resolution structure of DGAT2 or its complexes
  • Composition of the ~650 kDa complex unknown
  • Mechanism coupling localization to distinct LD product identity undefined

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0016740 transferase activity 3 GO:0016787 hydrolase activity 1
Localization
GO:0005811 lipid droplet 4 GO:0005783 endoplasmic reticulum 3 GO:0005739 mitochondrion 1
Pathway
R-HSA-1430728 Metabolism 3 R-HSA-1852241 Organelle biogenesis and maintenance 2
Partners
ATG2AMGAT2RAB1BSCD1
Complex memberships
DGAT2 homodimer / ~650 kDa membrane complexDGAT2-MGAT2 complex

Evidence

Reading pass · 23 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2001 DGAT2 encodes a diacylglycerol acyltransferase that catalyzes triacylglycerol synthesis using fatty acyl-CoA and diacylglycerol as substrates; activity was demonstrated in insect cell expression systems and is inhibited by high MgCl2 (100 mM), distinguishing it from DGAT1. It belongs to a gene family with no homology to DGAT1. Heterologous expression in insect cells, in vitro enzyme activity assay with radiolabeled substrates, substrate specificity assays The Journal of biological chemistry High 11481333 11481335
2003 DGAT2 is essential for mammalian survival; DGAT2-knockout mice are profoundly lipopenic and die shortly after birth due to energy substrate deficiency and impaired skin permeability barrier function. DGAT1 cannot compensate for loss of DGAT2, indicating the two enzymes serve fundamentally different roles. Gene knockout in mice (Dgat2-/- mice), phenotypic analysis including lipid quantification and skin barrier assays The Journal of biological chemistry High 14668353
2008 DGAT2 localizes to the endoplasmic reticulum under basal conditions and redistributes to lipid droplet surfaces and mitochondria-associated membranes (MAMs) upon oleate loading. The N-terminal 67 amino acids of DGAT2, containing a conserved positively charged mitochondrial targeting signal (residues 61–66), are sufficient to direct a fluorescent protein reporter to mitochondria. Live-cell fluorescence imaging, biochemical fractionation, deletion mutagenesis with fluorescent protein fusions, oleate loading experiments The Journal of biological chemistry High 19049983
2006 DGAT2 co-localizes with SCD1 (stearoyl-CoA desaturase 1) in the ER, as shown by confocal microscopy co-localization, co-immunoprecipitation, and FRET, consistent with substrate channeling of SCD1-generated monounsaturated fatty acids directly to DGAT2 for triglyceride synthesis. Confocal microscopy co-localization, co-immunoprecipitation, FRET in HeLa cells, subcellular fractionation of mouse liver Journal of lipid research Medium 16751624
2007 Antisense oligonucleotide knockdown of hepatic DGAT2 (but not DGAT1) in diet-induced obese rats reduces hepatic diacylglycerol and triglyceride content and reverses hepatic insulin resistance, associated with reduced SREBP1c-mediated lipogenesis and increased fatty acid oxidation, identifying DGAT2 as the isoform primarily linked to de novo lipogenic triglyceride synthesis. Antisense oligonucleotide knockdown in rats, hepatic lipid quantification, insulin sensitivity assays (hyperinsulinemic-euglycemic clamp), gene expression analysis The Journal of biological chemistry High 17526931
2004 Niacin noncompetitively inhibits DGAT2 but not DGAT1 activity in HepG2 microsomal fractions, decreasing apparent Vmax without altering Km, and has no effect on DGAT1 or DGAT2 mRNA expression. Microsomal enzyme activity assay, enzyme kinetics (Lineweaver-Burk), isoform-specific activity measurement in HepG2 cells Journal of lipid research Medium 15258194
2014 DGAT2 forms homodimers and is part of a ~650 kDa protein complex in membranes and on lipid droplets. DGAT2 physically interacts with MGAT2 (monoacylglycerol acyltransferase 2) via its two transmembrane domains, co-localizes with MGAT2 in the ER and on lipid droplets, and co-expression increases triglyceride storage. No significant interaction with lipin1 was detected. Chemical cross-linking (DSS), co-immunoprecipitation, in situ proximity ligation assay, deletion mutagenesis, confocal co-localization, lipid droplet imaging The Journal of biological chemistry High 25164810
2018 Imidazopyridine DGAT2 inhibitors (PF-06424439 and compound 2) act as slowly reversible, time-dependent, noncompetitive inhibitors with respect to acyl-CoA via a two-step binding mechanism (EI → EI* isomerization), with Ki*app ~16 nM and EI* dissociation half-lives of ~1 h. Histidine residues H161 and H163 are critical for inhibitor binding, as H161A and H163A mutations reduced inhibitor binding to 11–17% of wild-type. Enzyme kinetics assays, time-dependent inhibition analysis, radioligand binding with 125I-labeled inhibitor, site-directed mutagenesis Biochemistry High 30422629
2016 A de novo missense mutation (p.Y223H) in DGAT2 causes autosomal-dominant early-onset axonal Charcot-Marie-Tooth disease. Overexpression of mutant DGAT2 significantly inhibited proliferation of mouse motor neuron cells, and the variant inhibited axonal branching in zebrafish peripheral nervous system. Exome sequencing, in vitro motor neuron cell proliferation assay, zebrafish axonal branching assay Human mutation Medium 26786738
2019 In adipocyte-specific DGAT2 knockout mice, DGAT2 is not essential for adipose triglyceride storage or glucose metabolism on regular or high-fat diets, demonstrating that DGAT1 can fully compensate for DGAT2 loss specifically in adipocytes. Adipocyte-specific conditional knockout mice, body composition analysis, metabolic phenotyping on chow and high-fat diets Journal of lipid research High 30936184
2010 DGAT2 upregulation in alcoholic liver disease is mediated by suppression of the MEK/ERK1/2 pathway; specific MEK/ERK1/2 inhibitors increased DGAT2 expression and triglyceride content in HepG2 cells, while ERK1/2 activation (by EGF) had the opposite effect. Disrupted transmethylation (reduced SAM/SAH ratio) by alcohol contributes to ERK1/2 suppression and consequent DGAT2 upregulation. In vitro pharmacological inhibition of MEK/ERK pathway in HepG2 cells, mRNA/protein expression analysis, triglyceride quantification, in vivo alcohol feeding model with betaine supplementation Journal of lipid research Medium 20739640
2024 Rab1b, a GTPase regulating secretory transport, promotes DGAT2 redistribution from the ER to lipid droplet surfaces as shown by FRET between DGAT2 and Rab1b activity mutants. In TBC1D20-mutant (Warburg Micro syndrome) mouse fibroblasts, Rab1b activity and DGAT2 redistribution to lipid droplets are altered, linking this mechanism to a human disease. FRET analysis with DGAT2 and Rab1b mutants, dominant-negative overexpression, LD formation assays, analysis of TBC1D20-mutant mouse fibroblasts Science advances Medium 38809969
2025 ATG2A transfers DAG from the ER to lipid droplets; in ATG2A-deficient cells, DGAT2 fails to relocate to lipid droplets. In vitro, DAG recruits DGAT2 to lipid droplets. ATG2A-mediated DAG transfer is required for DGAT2 recruitment to the LD surface to promote LD expansion; DGAT2 inhibition reduces ATG2A-dependent LD growth. ATG2A loss-of-function, in vitro DAG-recruitment assay, LD imaging, DGAT2 inhibitor experiments Nature structural & molecular biology High 41249819
2025 Amyloid-β exposure drives microglial lipid droplet formation by increasing DGAT2 expression and shifting FFAs to TGs; pharmacological DGAT2 inhibition improved microglial Aβ phagocytosis and reduced plaque load and neuronal damage in 5xFAD mice. Pharmacological DGAT2 inhibition in vivo and in vitro, lipidomic analysis, microglial phagocytosis assays, plaque quantification in 5xFAD mice Immunity Medium 40393454
2021 In DGAT1-deficient HepG2 cells generated by CRISPR/Cas9 gene editing, endogenous DGAT2 protein stability is increased compared to wild-type cells, suggesting a compensatory post-translational mechanism regulating DGAT2 levels when DGAT1 is absent. CRISPR/Cas9 gene editing to FLAG-tag endogenous DGAT2, immunoblotting, DGAT1 inhibitor treatment Biochimica et biophysica acta. Molecular and cell biology of lipids Medium 34116261
2023 DGAT2-generated TG is stored in larger lipid droplets than DGAT1-generated TG in Huh7 hepatocytes; ATGL preferentially targets DGAT1-generated (smaller) LDs, and fatty acids from DGAT1-generated TG are preferentially used for beta-oxidation. Isoform-specific DGAT1/DGAT2 inhibitors in Huh7 cells, LD size analysis, ATGL co-localization, fatty acid oxidation assays Biochimica et biophysica acta. Molecular and cell biology of lipids Medium 37516308
2017 A nonsense variant (p.R128*) in DGAT2 severely damages TG-biosynthesis activity in vitro. FAAH overexpression inhibits DGAT2 expression and TG synthesis, and a loss-of-function FAAH variant (p.R315I) eliminates this inhibitory effect, suggesting FAAH regulates DGAT2 expression and TG synthesis. In vitro TG synthesis assay with DGAT2 mutant, FAAH overexpression and knockdown in cells, TG quantification Endocrine Medium 28243972
2020 CTRP12 (an adipokine) treatment in hepatoma cells and primary hepatocytes inhibits triglyceride synthesis by suppressing DGAT2 expression (along with GPAT), and also downregulates HNF-4α and MTTP, reducing VLDL-TG secretion. CTRP12 treatment of HepG2 cells and primary hepatocytes, DGAT expression analysis, VLDL-TG secretion assay, in vivo CTRP12 overexpression FEBS letters Medium 32749667
2014 uPA stimulates triglyceride synthesis in Huh7 hepatoma cells via p38-dependent upregulation of DGAT2 expression; p38 inhibition abolishes uPA-stimulated triglyceride synthesis and DGAT2 upregulation. The effect requires binding of uPA to its receptor uPAR. uPA treatment with p38 inhibitors in Huh7 cells, TG synthesis assays, gene expression analysis, uPAR knockout mice Atherosclerosis Medium 25244504
2018 In hepatocyte-specific DGAT1-knockout (DGAT1-LKO) mice, VLDL particle number is maintained (DGAT2 can fully support apoB secretion), but particle size and TG content per particle are approximately halved, demonstrating DGAT1 is uniquely required for full VLDL particle lipidation in the ER lumen while DGAT2 supports particle number. Hepatocyte-specific DGAT1 KO mice, Triton WR1339-based VLDL secretion assay, apoB quantification, electron microscopy of liver ER, DGAT isoform-specific inhibitors in HepG2 cells Journal of lipid research High 30397187
2023 Knockdown of DGAT2 in C2C12 skeletal myotubes reduces glucose uptake (2-deoxyglucose), decreases GLUT4 mRNA, impairs insulin-stimulated Akt phosphorylation, and shifts oleic acid away from TG re-esterification toward free fatty acid accumulation and beta-oxidation, demonstrating DGAT2 regulates both glucose uptake and fatty acid partitioning in skeletal muscle. siRNA knockdown in C2C12 myotubes, radiolabeled glucose uptake assay, radiolabeled fatty acid incorporation assay, Akt phosphorylation immunoblot Journal of microbiology and biotechnology Medium 37644753
2024 DGAT2 knockdown in HepG2 cells suppresses mitochondrial function and promotes cell proliferation, associated with downregulation of ESRRA (estrogen-related receptor alpha) and increased ESRRA dimerization with corepressor PROX1, indicating DGAT2 sustains hepatic mitochondrial function partly through the ESRRA-PROX1 transcriptional network. DGAT2 knockdown in HepG2 cells, transcriptome analysis, ISMARA motif analysis, co-expression analysis from patient cohorts Diabetes & metabolism journal Low 38644620
2019 DGAT2 partially compensates for LD formation in DGAT1-deficient human intestinal organoids; overexpression of DGAT2 fully rescues LD formation and lipotoxicity caused by DGAT1 deficiency. Lipotoxicity in this context is mediated by ER stress. Patient-derived intestinal organoids with DGAT1 deficiency, DGAT2 overexpression rescue experiments, LD imaging, ER stress markers Journal of lipid research Medium 31315900

Source papers

Stage 0 corpus · 97 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2001 Cloning of DGAT2, a second mammalian diacylglycerol acyltransferase, and related family members. The Journal of biological chemistry 614 11481335
2003 Lipopenia and skin barrier abnormalities in DGAT2-deficient mice. The Journal of biological chemistry 479 14668353
2006 Tung tree DGAT1 and DGAT2 have nonredundant functions in triacylglycerol biosynthesis and are localized to different subdomains of the endoplasmic reticulum. The Plant cell 393 16920778
2008 The endoplasmic reticulum enzyme DGAT2 is found in mitochondria-associated membranes and has a mitochondrial targeting signal that promotes its association with mitochondria. The Journal of biological chemistry 329 19049983
2007 Suppression of diacylglycerol acyltransferase-2 (DGAT2), but not DGAT1, with antisense oligonucleotides reverses diet-induced hepatic steatosis and insulin resistance. The Journal of biological chemistry 318 17526931
2001 DGAT2 is a new diacylglycerol acyltransferase gene family: purification, cloning, and expression in insect cells of two polypeptides from Mortierella ramanniana with diacylglycerol acyltransferase activity. The Journal of biological chemistry 260 11481333
2005 Antisense oligonucleotide reduction of DGAT2 expression improves hepatic steatosis and hyperlipidemia in obese mice. Hepatology (Baltimore, Md.) 247 16001399
2004 Niacin noncompetitively inhibits DGAT2 but not DGAT1 activity in HepG2 cells. Journal of lipid research 175 15258194
2006 Colocalization of SCD1 and DGAT2: implying preference for endogenous monounsaturated fatty acids in triglyceride synthesis. Journal of lipid research 170 16751624
2019 The triglyceride synthesis enzymes DGAT1 and DGAT2 have distinct and overlapping functions in adipocytes. Journal of lipid research 142 30936184
2006 Identification and functional expression of a type 2 acyl-CoA:diacylglycerol acyltransferase (DGAT2) in developing castor bean seeds which has high homology to the major triglyceride biosynthetic enzyme of fungi and animals. Phytochemistry 134 17084870
2010 DGAT1, DGAT2 and PDAT expression in seeds and other tissues of epoxy and hydroxy fatty acid accumulating plants. Lipids 114 20101470
2002 Concerted elevation of acyl-coenzyme A:diacylglycerol acyltransferase (DGAT) activity through independent stimulation of mRNA expression of DGAT1 and DGAT2 by carbohydrate and insulin. Biochemical and biophysical research communications 105 12413942
2013 Hepatic triacylglycerol synthesis and secretion: DGAT2 as the link between glycaemia and triglyceridaemia. The Biochemical journal 96 23489367
2005 Identification of two novel human acyl-CoA wax alcohol acyltransferases: members of the diacylglycerol acyltransferase 2 (DGAT2) gene superfamily. The Journal of biological chemistry 91 15671038
2014 Diacylglycerol acyltransferase-2 (DGAT2) and monoacylglycerol acyltransferase-2 (MGAT2) interact to promote triacylglycerol synthesis. The Journal of biological chemistry 69 25164810
2025 Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer's disease. Immunity 65 40393454
2009 The DGAT2 gene is a candidate for the dissociation between fatty liver and insulin resistance in humans. Clinical science (London, England : 1979) 65 18980578
2018 DGAT2 Inhibition Alters Aspects of Triglyceride Metabolism in Rodents but Not in Non-human Primates. Cell metabolism 63 29706567
2010 Identification and characterization of an acyl-CoA:diacylglycerol acyltransferase 2 (DGAT2) gene from the microalga O. tauri. Plant physiology and biochemistry : PPB 63 20400321
2020 Oil-Producing Metabolons Containing DGAT1 Use Separate Substrate Pools from those Containing DGAT2 or PDAT. Plant physiology 53 32732347
2021 Lipid Droplet Biosynthesis Impairment through DGAT2 Inhibition Sensitizes MCF7 Breast Cancer Cells to Radiation. International journal of molecular sciences 52 34576263
2013 Identification and characterization of PtDGAT2B, an acyltransferase of the DGAT2 acyl-coenzyme A: diacylglycerol acyltransferase family in the diatom Phaeodactylum tricornutum. FEBS letters 51 23337871
2010 Involvement and mechanism of DGAT2 upregulation in the pathogenesis of alcoholic fatty liver disease. Journal of lipid research 51 20739640
2010 The olive DGAT2 gene is developmentally regulated and shares overlapping but distinct expression patterns with DGAT1. Journal of experimental botany 50 20870930
2004 Expression of DGAT2 in white adipose tissue is regulated by central leptin action. The Journal of biological chemistry 48 15550388
2024 The role of DGAT1 and DGAT2 in regulating tumor cell growth and their potential clinical implications. Journal of translational medicine 44 38500157
2009 Fenofibrate ameliorates diabetic and dyslipidemic profiles in KKAy mice partly via down-regulation of 11beta-HSD1, PEPCK and DGAT2. Comparison of PPARalpha, PPARgamma, and liver x receptor agonists. European journal of pharmacology 44 19245804
2003 A novel diacylglycerol acyltransferase (DGAT2) is decreased in human psoriatic skin and increased in diabetic mice. Biochemical and biophysical research communications 44 14521909
2016 DGAT2 Mutation in a Family with Autosomal-Dominant Early-Onset Axonal Charcot-Marie-Tooth Disease. Human mutation 42 26786738
2018 In silico characterization and expression profiling of the diacylglycerol acyltransferase gene family (DGAT1, DGAT2, DGAT3 and WS/DGAT) from oil palm, Elaeis guineensis. Plant science : an international journal of experimental plant biology 36 30107884
2021 An RNAi therapeutic targeting hepatic DGAT2 in a genetically obese mouse model of nonalcoholic steatohepatitis. Molecular therapy : the journal of the American Society of Gene Therapy 34 34774753
2022 DGAT2 Inhibition Potentiates Lipid Droplet Formation To Reduce Cytotoxicity in APOL1 Kidney Risk Variants. Journal of the American Society of Nephrology : JASN 31 35232775
2020 Involvement of CYP2E1-ROS-CD36/DGAT2 axis in the pathogenesis of VPA-induced hepatic steatosis in vivo and in vitro. Toxicology 27 33007364
2007 Mutation screen and association studies in the diacylglycerol O-acyltransferase homolog 2 gene (DGAT2), a positional candidate gene for early onset obesity on chromosome 11q13. BMC genetics 27 17477860
2024 The translational potential of miR-26 in atherosclerosis and development of agents for its target genes ACC1/2, COL1A1, CPT1A, FBP1, DGAT2, and SMAD7. Cardiovascular diabetology 25 38195542
2015 Identification of a 13 bp indel polymorphism in the 3'-UTR of DGAT2 gene associated with backfat thickness and lean percentage in pigs. Gene 23 26407871
2022 Overexpression of DGAT2 Stimulates Lipid Droplet Formation and Triacylglycerol Accumulation in Bovine Satellite Cells. Animals : an open access journal from MDPI 22 35883393
2019 DGAT2 partially compensates for lipid-induced ER stress in human DGAT1-deficient intestinal stem cells. Journal of lipid research 19 31315900
2014 Characterisation of DGAT1 and DGAT2 from Jatropha curcas and their functions in storage lipid biosynthesis. Functional plant biology : FPB 18 32480992
2018 Hepatic VLDL secretion: DGAT1 determines particle size but not particle number, which can be supported entirely by DGAT2. Journal of lipid research 17 30397187
2015 Identification of DGAT2 Inhibitors Using Mass Spectrometry. Journal of biomolecular screening 17 26403520
2011 Isolation, mapping, SNP detection and association with backfat traits of the porcine CTNNBL1 and DGAT2 genes. Molecular biology reports 17 21997828
2003 Genomic organization of the DGAT2/MOGAT gene family in cattle (Bos taurus) and other mammals. Cytogenetic and genome research 17 14970677
2020 Enhanced triacylglycerol production in oleaginous microalga Neochloris oleoabundans by co-overexpression of lipogenic genes: Plastidial LPAAT1 and ER-located DGAT2. Journal of bioscience and bioengineering 16 33069576
2018 Association of DGAT2 gene polymorphisms with carcass and meat quality traits in domestic pigeons (Columba livia). British poultry science 16 29207879
2024 DGAT1 and DGAT2 Inhibitors for Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Management: Benefits for Their Single or Combined Application. International journal of molecular sciences 15 39201759
2021 CD36 and DGAT2 facilitate the lipid-lowering effect of chitooligosaccharides via fatty acid intake and triglyceride synthesis signaling. Food & function 15 34351342
2012 Rescue of Mtp siRNA-induced hepatic steatosis by DGAT2 siRNA silencing. Journal of lipid research 15 22355095
2022 Expression of DGAT2 Gene and Its Associations With Intramuscular Fat Content and Breast Muscle Fiber Characteristics in Domestic Pigeons (Columba livia). Frontiers in veterinary science 14 35754541
2017 Genetic interaction of DGAT2 and FAAH in the development of human obesity. Endocrine 14 28243972
2025 Antisense oligonucleotide DGAT-2 inhibitor, ION224, for metabolic dysfunction-associated steatohepatitis (ION224-CS2): results of a 51-week, multicentre, randomised, double-blind, placebo-controlled, phase 2 trial. Lancet (London, England) 13 40849139
2024 The role of DGAT1 and DGAT2 in tumor progression via fatty acid metabolism: A comprehensive review. International journal of biological macromolecules 13 39154689
2020 CTRP12 inhibits triglyceride synthesis and export in hepatocytes by suppressing HNF-4α and DGAT2 expression. FEBS letters 12 32749667
2019 Resveratrol protects against hepatic insulin resistance in a rat's model of non-alcoholic fatty liver disease by down-regulation of GPAT-1 and DGAT2 expression and inhibition of PKC membranous translocation. Clinical and experimental pharmacology & physiology 12 30773673
2015 Dietary Omega-3 Fatty Acids Prevented Adipocyte Hypertrophy by Downregulating DGAT-2 and FABP-4 in a Sex-Dependent Fashion. Lipids 12 26662277
2014 Dictyostelium discoideum Dgat2 can substitute for the essential function of Dgat1 in triglyceride production but not in ether lipid synthesis. Eukaryotic cell 12 24562909
2024 Diurnal expression of Dgat2 induced by time-restricted feeding maintains cardiac health in the Drosophila model of circadian disruption. Aging cell 11 38616316
2024 Rab1b facilitates lipid droplet growth by ER-to-lipid droplet targeting of DGAT2. Science advances 11 38809969
2021 DGAT2 stability is increased in response to DGAT1 inhibition in gene edited HepG2 cells. Biochimica et biophysica acta. Molecular and cell biology of lipids 11 34116261
2019 Tangduqing Granules Attenuate Insulin Resistance and Abnormal Lipid Metabolism through the Coordinated Regulation of PPARγ and DGAT2 in Type 2 Diabetic Rats. Journal of diabetes research 11 31019978
2023 Preferential lipolysis of DGAT1 over DGAT2 generated triacylglycerol in Huh7 hepatocytes. Biochimica et biophysica acta. Molecular and cell biology of lipids 10 37516308
2015 Treatment of rats with Jiangzhi Capsule improves liquid fructose-induced fatty liver: modulation of hepatic expression of SREBP-1c and DGAT-2. Journal of translational medicine 10 26031670
2023 Overexpression of DGAT2 Regulates the Differentiation of Bovine Preadipocytes. Animals : an open access journal from MDPI 9 37048451
2021 Low expression of miR-19a-5p is associated with high mRNA expression of diacylglycerol O-acyltransferase 2 (DGAT2) in hybrid tilapia. Genomics 9 34022348
2019 Tissue Expression and Variation of the DGAT2 Gene and Its Effect on Carcass and Meat Quality Traits in Yak. Animals : an open access journal from MDPI 9 30769898
2011 The effect of excess cobalt on milk fatty acid profiles and transcriptional regulation of SCD, FASN, DGAT1 and DGAT2 in the mammary gland of lactating dairy cows. Journal of animal physiology and animal nutrition 9 21895781
2020 Pluripotent Stem Cell-Derived Hepatocytes Phenotypic Screening Reveals Small Molecules Targeting the CDK2/4-C/EBPα/DGAT2 Pathway Preventing ER-Stress Induced Lipid Accumulation. International journal of molecular sciences 8 33334026
2018 Mechanistic Characterization of Long Residence Time Inhibitors of Diacylglycerol Acyltransferase 2 (DGAT2). Biochemistry 8 30422629
2025 ATG2A-mediated DAG transfer recruits DGAT2 for lipid droplet growth. Nature structural & molecular biology 6 41249819
2023 Role of Dgat2 in Glucose Uptake and Fatty Acid Metabolism in C2C12 Skeletal Myotubes. Journal of microbiology and biotechnology 6 37644753
2016 Cutinsomes and cuticle enzymes GPAT6 and DGAT2 seem to travel together from a lipotubuloid metabolon (LM) to extracellular matrix of O. umbellatum ovary epidermis. Micron (Oxford, England : 1993) 6 27088229
2014 Urokinase-type plasminogen activator (uPA) stimulates triglyceride synthesis in Huh7 hepatoma cells via p38-dependent upregulation of DGAT2. Atherosclerosis 6 25244504
2014 Identification and characterization of a type-2 diacylglycerol acyltransferase (DGAT2) from Rhodosporidium diobovatum. Antonie van Leeuwenhoek 6 25294723
2025 Regulation of lipid dysmetabolism and neuroinflammation progression linked with Alzheimer's disease through modulation of Dgat2. bioRxiv : the preprint server for biology 5 40027815
2024 Apolipoprotein E Induces Lipid Accumulation Through Dgat2 That Is Prevented with Time-Restricted Feeding in Drosophila. Genes 5 39596576
2016 Expressional profiling of prostate cancer risk SNPs at 11q13.5 identifies DGAT2 as a new target gene. Genes, chromosomes & cancer 5 27113481
2025 DGAT2 reduction and lipid dysregulation drive psoriasis development in keratinocyte-specific SPRY1-deficient mice. JCI insight 4 40694426
2024 The transcription factor MYB1 activates DGAT2 transcription to promote triacylglycerol accumulation in sacha inchi (Plukenetia volubilis L.) leaves under heat stress. Plant physiology and biochemistry : PPB 4 38503190
2023 Newly identified essential amino acids affecting peanut (Arachis hypogaea L.) DGAT2 enzyme activity. Heliyon 4 36711321
2023 Dual targeting of hepatocyte DGAT2 and stellate cell FASN alleviates nonalcoholic steatohepatitis in mice. bioRxiv : the preprint server for biology 4 37461560
2023 Characterization of thraustochytrid-specific sterol O-acyltransferase: modification of DGAT2-like enzyme to increase the sterol production in Aurantiochytrium limacinum mh0186. Applied and environmental microbiology 4 37874286
2020 Identification, molecular characteristics, and tissue differential expression of DGAT2 full-CDS cDNA sequence in Binglangjiang buffalo (Bubalus bubalis). Archives animal breeding 4 32232120
2012 FAD2-DGAT2 genes coexpressed in endophytic Aspergillus fumigatus derived from tung oilseeds. TheScientificWorldJournal 4 22919314
2008 [Association of polymorphisms of DGAT2 gene with growth traits in Jiaxian red cattle]. Yi chuan = Hereditas 4 18332002
2022 Corrigendum: Expression of DGAT2 gene and its associations with intramuscular fat content and breast muscle fiber characteristics in domestic pigeons (Columba livia). Frontiers in veterinary science 3 36187813
2024 DGAT2 Plays a Crucial Role to Control ESRRA-PROX1 Transcriptional Network to Maintain Hepatic Mitochondrial Sustainability. Diabetes & metabolism journal 2 38644620
2021 DGAT2-MOGAT2 SNPs and Gene-Environment Interactions on Serum Lipid Profiles and the Risk of Ischemic Stroke. Frontiers in cardiovascular medicine 2 34901200
2019 The Amphibian Diacylglycerol O-acyltransferase 2 (DGAT2): a 'paleo-protein' with Conserved Function but Unique Folding. The protein journal 2 30697667
2007 [Polymorphisms of DGAT2 gene and its associations with several growth traits in Nanyang cattle]. Yi chuan = Hereditas 2 17681922
2026 Regulation of Lipid Dysmetabolism and Neuroinflammation Progression Linked With Alzheimer's Disease Through Modulation of Dgat2. Aging cell 1 41832772
2025 miR-10c Targets dgat2 and Affects the Expression of Genes Involved in Fatty Acid and Triglyceride Metabolism in Oreochromis niloticus Under Heat Stress. International journal of molecular sciences 1 41096982
2022 The Postnatal Resolution of Developmental Toxicity Induced by Pharmacological Diacylglycerol Acyltransferase 2 (DGAT2) Inhibition During Gestation in Rats. Toxicological sciences : an official journal of the Society of Toxicology 1 35866640
2026 Inflammation promotes hepatic but not adipose tissue DGAT2 expression and triglyceride synthesis in MAFLD mice. Pathology, research and practice 0 41814114
2026 APOC3 Promotes DGAT2-Dependent Triglyceride Accumulation in Hepatocytes During Early Metabolic Dysfunction. Biomolecules 0 42072728
2025 Effect of Varying Degrees of Hepatic Impairment on the Pharmacokinetics of Ervogastat, a Diacylglycerol Acyltransferase 2 (DGAT2) Inhibitor, and Clesacostat, an Acetyl-CoA Carboxylase (ACC) Inhibitor. Journal of clinical pharmacology 0 40996355
2008 [Research progress on diacylgycerol acyltransferase 2 (DGAT2) gene]. Yi chuan = Hereditas 0 18331995

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