Affinage

DGAT2

Diacylglycerol O-acyltransferase 2 · UniProt Q96PD7

Length
388 aa
Mass
43.8 kDa
Annotated
2026-04-28
100 papers in source corpus 20 papers cited in narrative 20 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

DGAT2 is an ER-resident diacylglycerol acyltransferase that catalyzes the final committed step of triacylglycerol (TG) biosynthesis, transferring a fatty acyl group from acyl-CoA to diacylglycerol, and is essential for mammalian survival as demonstrated by neonatal lethality of DGAT2-null mice due to lipopenia and skin barrier failure (PMID:11481335, PMID:14668353). Under lipid-loading conditions, DAG generated by ATG2A-mediated lipid transfer and MGAT2 activity recruits DGAT2 from the ER to lipid droplet surfaces, where it forms a ~650 kDa complex with MGAT2 and channels substrates for TG storage into large lipid droplets; this relocalization is further promoted by the GTPase Rab1b (PMID:25164810, PMID:41249819, PMID:38809969). DGAT2 also physically interacts with SCD1 in the ER to channel monounsaturated fatty acids into TG, and its expression is regulated by SREBP1c-mediated lipogenesis and MEK/ERK signaling (PMID:16751624, PMID:17526931, PMID:20739640). A missense mutation (p.Y223H) in DGAT2 causes autosomal-dominant axonal Charcot-Marie-Tooth disease (PMID:26786738).

Mechanistic history

Synthesis pass · year-by-year structured walk · 13 steps
  1. 2001 High

    Identifying DGAT2 as a novel acyltransferase unrelated to DGAT1 established that mammals possess two mechanistically independent enzymes for the terminal step of TG synthesis.

    Evidence Heterologous expression in insect cells with radiolabeled substrate assays and kinetic characterization; independent purification from fungal lipid bodies with cDNA cloning

    PMID:11481333 PMID:11481335

    Open questions at the time
    • No structural information on the active site
    • Substrate channeling mechanism unknown
    • Relative contributions of DGAT1 vs DGAT2 in vivo undefined
  2. 2003 High

    Demonstrating that DGAT2 knockout is neonatally lethal while DGAT1 knockout is not revealed that the two DGAT enzymes have non-redundant physiological roles, with DGAT2 essential for skin barrier lipids and systemic TG homeostasis.

    Evidence Germline knockout mice with lipid quantification, histological analysis of skin barrier, and metabolic profiling

    PMID:14668353

    Open questions at the time
    • Whether DGAT2 essentiality is tissue-specific was unclear
    • Mechanism of skin barrier lipid dependence on DGAT2 unresolved
  3. 2006 High

    Discovery that DGAT2 physically interacts with SCD1 in the ER via co-IP and FRET established a substrate channeling model in which monounsaturated fatty acids produced by SCD1 are directly funneled to DGAT2 for TG synthesis.

    Evidence Co-immunoprecipitation, confocal colocalization, and FRET in HeLa cells; subcellular fractionation of mouse liver

    PMID:16751624

    Open questions at the time
    • Stoichiometry and structural basis of SCD1–DGAT2 interaction unknown
    • Whether channeling is obligatory or modulatory not resolved
  4. 2007 High

    ASO knockdown of DGAT2 in obese rats reversed hepatic steatosis and insulin resistance, placing DGAT2 downstream of SREBP1c in de novo lipogenesis and demonstrating its pathophysiological role in fatty liver disease.

    Evidence In vivo ASO knockdown with hyperinsulinemic-euglycemic clamp, hepatic DAG/TG quantification, and gene expression analysis

    PMID:17526931

    Open questions at the time
    • Direct transcriptional regulation of DGAT2 by SREBP1c not shown at the promoter level
    • Relative contribution of reduced TG synthesis vs increased oxidation to phenotype unclear
  5. 2008 High

    Identifying that DGAT2 redistributes from the ER to lipid droplet–mitochondria contact sites upon oleate loading, and that its unique N-terminal mitochondrial targeting signal mediates MAM localization, revealed how DGAT2 accesses different membrane compartments for TG synthesis.

    Evidence Live-cell imaging, subcellular fractionation, MAM isolation, and deletion mutagenesis with RFP fusions

    PMID:19049983

    Open questions at the time
    • Functional consequence of mitochondrial targeting for TG metabolism not established
    • Signal for return to ER not identified
  6. 2014 High

    Discovery that DGAT2 forms homodimers within a ~650 kDa complex containing MGAT2, and that MGAT2-derived DAG triggers DGAT2 translocation to lipid droplets, established a substrate-channeling complex that couples sequential acylation reactions on LD surfaces.

    Evidence Chemical cross-linking, co-IP, proximity ligation assay, deletion mutagenesis, and TG storage assays in McArdle RH7777 cells

    PMID:25164810

    Open questions at the time
    • Full composition of the ~650 kDa complex not determined
    • Whether MGAT2–DGAT2 coupling is obligatory for LD-directed TG synthesis unknown
  7. 2016 Medium

    Identification of a dominantly acting DGAT2 p.Y223H mutation causing axonal Charcot-Marie-Tooth disease extended DGAT2's functional significance beyond lipid storage to neuronal/axonal biology.

    Evidence Exome sequencing, overexpression in mouse motor neuron cells (proliferation assay), zebrafish axonal branching assay

    PMID:26786738

    Open questions at the time
    • Mechanism by which DGAT2 mutation impairs axonal branching unknown
    • Whether enzymatic activity or an alternative function is affected not determined
    • Single family reported
  8. 2018 High

    Detailed kinetic characterization of DGAT2 inhibitors revealed a two-step slow-onset inhibition mechanism and identified H161/H163 as critical residues for inhibitor binding, providing the first active-site mapping of the enzyme.

    Evidence Time-dependent inhibition kinetics, radioligand binding, site-directed mutagenesis of H161A and H163A

    PMID:30422629

    Open questions at the time
    • No crystal or cryo-EM structure of DGAT2
    • Whether H161/H163 are catalytic residues or only inhibitor-binding residues not resolved
  9. 2018 High

    Delineating that DGAT2 primarily supports VLDL particle number while DGAT1 determines VLDL particle size established distinct roles for the two enzymes in hepatic lipoprotein assembly.

    Evidence Liver-specific DGAT1 KO mice, DGAT1/DGAT2-specific inhibitors in HepG2 cells, VLDL secretion assays, electron microscopy

    PMID:30397187

    Open questions at the time
    • Whether DGAT2 directly lipidates apoB or acts indirectly via ER TG pools not determined
    • Mechanism of functional compensation between DGAT1 and DGAT2 for apoB secretion unknown
  10. 2023 Medium

    Showing that DGAT2-synthesized TG preferentially populates larger lipid droplets while DGAT1-synthesized TG goes to smaller, ATGL-accessible droplets defined distinct metabolic fates for TG produced by each enzyme.

    Evidence Selective pharmacological inhibition of DGAT1/DGAT2 in Huh7 cells, LD size quantification, ATGL colocalization, fatty acid oxidation measurement

    PMID:37516308

    Open questions at the time
    • Mechanism determining LD size specificity unknown
    • Whether this reflects ER subdomain localization or LD surface targeting not resolved
  11. 2024 Medium

    Identification of Rab1b as a GTPase promoting DGAT2 redistribution from ER to lipid droplets, with disease relevance via the Rab1b-GAP TBC1D20 in Warburg Micro syndrome, revealed a GTPase-regulated trafficking step in DGAT2 targeting.

    Evidence FRET between DGAT2 and Rab1b activity mutants, dominant-negative Rab1b, in vitro DAG recruitment assay, Warburg Micro syndrome mouse fibroblasts

    PMID:38809969

    Open questions at the time
    • Direct physical interaction between Rab1b and DGAT2 not confirmed by reciprocal pull-down
    • Whether Rab1b acts on DGAT2 directly or via membrane remodeling not established
  12. 2025 High

    Reconstitution of ATG2A-mediated DAG transfer from ER to lipid droplets as the upstream signal recruiting DGAT2 to LDs unified the DAG-sensing, ER-to-LD relocalization, and LD expansion mechanisms into a single pathway.

    Evidence In vitro lipid transfer reconstitution, ATG2A KO/KD, DAG-mediated DGAT2 recruitment to artificial LDs, live-cell imaging

    PMID:41249819

    Open questions at the time
    • DAG-binding domain on DGAT2 not mapped
    • Whether other lipid transfer proteins can substitute for ATG2A unknown
  13. 2025 High

    Demonstration that amyloid-β induces DGAT2-dependent lipid droplet accumulation in microglia and that DGAT2 inhibition restores Aβ phagocytosis and reduces plaque burden established DGAT2 as a pathogenic mediator in Alzheimer's disease neuroinflammation.

    Evidence Lipidomics of Aβ-treated microglia, DGAT2 KO and pharmacological inhibition, phagocytosis assay, 5xFAD mouse model with plaque quantification

    PMID:40393454

    Open questions at the time
    • Whether DGAT2 inhibition affects microglial polarization beyond LD metabolism not determined
    • Long-term cognitive outcomes of DGAT2 inhibition not assessed

Open questions

Synthesis pass · forward-looking unresolved questions
  • No high-resolution structure of DGAT2 exists; the catalytic mechanism, the DAG-sensing domain mediating LD recruitment, the basis for DGAT1/DGAT2 non-redundancy at the structural level, and the mechanism linking DGAT2 to axonal integrity remain unresolved.
  • No crystal or cryo-EM structure available
  • DAG-binding site on DGAT2 not mapped
  • Molecular basis of axonal CMT phenotype completely unknown

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0008289 lipid binding 3 GO:0016740 transferase activity 2
Localization
GO:0005811 lipid droplet 4 GO:0005783 endoplasmic reticulum 2 GO:0005739 mitochondrion 1
Pathway
R-HSA-1430728 Metabolism 7 R-HSA-162582 Signal Transduction 2 R-HSA-1643685 Disease 2
Partners
ATG2AFAAHMGAT2RAB1BSCD1TBC1D20
Complex memberships
DGAT2–MGAT2 ~650 kDa complex

Evidence

Reading pass · 20 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2001 DGAT2 is a diacylglycerol acyltransferase that catalyzes the final step of triacylglycerol synthesis using fatty acyl-CoA and diacylglycerol as substrates; it has no sequence homology to DGAT1, is inhibited by high MgCl2 concentrations, and shows no activity toward acyl acceptors other than diacylglycerol. Expression in insect cells followed by membrane-based enzymatic assay with radiolabeled substrates; substrate specificity and inhibition kinetics The Journal of biological chemistry High 11481335
2001 DGAT2 defines a new gene family (originally identified from Mortierella ramanniana) unrelated to DGAT1/ACAT family, encoding enzymes with DGAT activity that co-purify with lipid bodies and have broad activity optimum between pH 6–8. Protein purification from fungal lipid bodies, partial peptide sequencing, cDNA cloning, heterologous expression in insect cells with DGAT activity assay The Journal of biological chemistry High 11481333
2003 DGAT2 is required for survival in mice; DGAT2-deficient mice are lipopenic and die neonatally due to profound reductions in triglyceride substrates for energy metabolism and impaired skin permeability barrier function; DGAT1 cannot compensate for DGAT2 loss, indicating the two enzymes have fundamentally different roles in triglyceride metabolism. Gene knockout in mice; biochemical analysis of lipid content; histological analysis of skin barrier The Journal of biological chemistry High 14668353
2004 Niacin noncompetitively inhibits DGAT2 but not DGAT1 activity in HepG2 cells, decreasing apparent Vmax without changing Km, acting on overt (cytosolic-facing) DGAT activity. Microsomal DGAT activity assay with radiolabeled substrates, Lineweaver-Burk kinetic analysis, selective DGAT1/DGAT2 inhibition comparison Journal of lipid research Medium 15258194
2006 DGAT2 co-localizes with SCD1 in the ER as demonstrated by confocal microscopy, co-immunoprecipitation, and FRET, supporting substrate channeling of SCD1-produced monounsaturated fatty acids directly to DGAT2 for triglyceride synthesis. Co-immunoprecipitation, confocal colocalization, FRET in HeLa cells; subcellular fractionation of mouse liver Journal of lipid research High 16751624
2007 Antisense oligonucleotide knockdown of DGAT2 (but not DGAT1) in diet-induced obese rats reverses hepatic steatosis and insulin resistance by reducing hepatic diacylglycerol content via decreased SREBP1c-mediated lipogenesis and increased fatty acid oxidation, placing DGAT2 downstream of SREBP1c in the hepatic de novo lipogenesis pathway. ASO-mediated knockdown in vivo, hepatic lipid quantification, gene expression analysis, hyperinsulinemic-euglycemic clamp, DAG/TG/LCFA-CoA measurement The Journal of biological chemistry High 17526931
2008 DGAT2 localizes to the ER under basal conditions, but after oleate stimulation also localizes near lipid droplet surfaces where it co-localizes with mitochondria; DGAT2 is present in mitochondria-associated membranes (MAM). The N-terminal 67 amino acids of DGAT2 (not conserved in family members) contain a positively charged mitochondrial targeting signal (residues 61–66) sufficient to direct a red fluorescent protein to mitochondria. Live-cell imaging, subcellular fractionation, biochemical MAM isolation, deletion mutagenesis with RFP fusion constructs in cultured cells The Journal of biological chemistry High 19049983
2014 DGAT2 forms homodimers and is part of a ~650 kDa protein complex in membranes and on lipid droplets; DGAT2 physically interacts with MGAT2 (monoacylglycerol acyltransferase 2) via its two transmembrane domains. Co-expression of DGAT2 and MGAT2 increases TG storage above either enzyme alone, and MGAT2-derived DAG triggers DGAT2 translocation to lipid droplets. Chemical cross-linking (DSS), co-immunoprecipitation, in situ proximity ligation assay, deletion mutagenesis, colocalization, TG storage measurement in McArdle RH7777 cells The Journal of biological chemistry High 25164810
2016 A missense mutation (p.Y223H) in DGAT2 causes autosomal-dominant axonal Charcot-Marie-Tooth disease; overexpression of the mutant DGAT2 inhibits proliferation of mouse motor neuron cells and inhibits axonal branching in zebrafish peripheral nervous system, indicating DGAT2 function in neuronal/axonal biology. Exome sequencing, overexpression of mutant DGAT2 in mouse motor neuron cells (proliferation assay), zebrafish axonal branching assay Human mutation Medium 26786738
2018 Imidazopyridine inhibitors (including PF-06424439) are slowly reversible, noncompetitive (with respect to acyl-CoA) time-dependent inhibitors of DGAT2 that engage via a two-step binding mechanism (EI→EI* isomerization). Mutagenesis of H161 and H163 dramatically reduces inhibitor binding, identifying these histidine residues as critical for the inhibitor binding site. Kinetic inhibition analysis, time-dependent inhibition assays, active-site mutagenesis (H161A, H163A), 125I-labeled radioligand binding assay Biochemistry High 30422629
2018 In mouse hepatocytes and rodent models, DGAT2 inhibition reduces VLDL-TG secretion and hepatic lipid; DGAT2 primarily supports apoB particle number (VLDL secretion) and DGAT1 determines VLDL particle size/lipidation within the ER lumen; the two enzymes can largely compensate for each other for apoB secretion. Liver-specific DGAT1 knockout mice (Triton WR-1339 VLDL secretion assay), DGAT1/DGAT2-specific inhibitors in HepG2 cells, electron microscopy of ER lipid content, microsomal TAG/protein ratios Journal of lipid research High 30397187
2019 In adipocytes, DGAT2 and DGAT1 can largely compensate for each other for TG storage; adipocyte-specific DGAT2 knockout mice have normal TG storage on chow or high-fat diet, while DGAT1 adipocyte-specific knockout causes reduced body fat and glucose intolerance on high-fat diet associated with ER stress activation. Adipocyte-specific conditional knockout mice, body composition measurement, metabolic testing (glucose tolerance, insulin tolerance), ER stress pathway analysis Journal of lipid research High 30936184
2021 DGAT2 stability is increased when DGAT1 is inhibited, suggesting a compensatory regulation of DGAT2 protein levels in response to DGAT1 loss. Endogenous DGAT2 protein was successfully detected by CRISPR/Cas9-mediated insertion of a 3×FLAG tag at the C-terminus in HepG2 cells. CRISPR/Cas9 knock-in epitope tagging of endogenous DGAT2, immunoblotting, DGAT1 inhibitor treatment Biochimica et biophysica acta. Molecular and cell biology of lipids Medium 34116261
2023 DGAT2-synthesized TG is stored in larger lipid droplets whereas DGAT1-synthesized TG accumulates in smaller lipid droplets; adipose triglyceride lipase (ATGL) preferentially targets lipid droplets generated by DGAT1, and fatty acids from DGAT1-made TG are preferentially used for beta-oxidation. Individual DGAT1/DGAT2 inhibition in Huh7 hepatocytes, ATGL colocalization, fatty acid oxidation measurement, lipid droplet size quantification Biochimica et biophysica acta. Molecular and cell biology of lipids Medium 37516308
2024 Rab1b GTPase promotes DGAT2 redistribution from the ER to lipid droplet surfaces (demonstrated by FRET between DGAT2 and Rab1b and activity mutants); DAG recruits DGAT2 to lipid droplets in vitro. In Warburg Micro syndrome model mouse fibroblasts, mutations in the Rab1b-GAP TBC1D20 alter LD metabolism consistent with Rab1b activity on DGAT2. FRET between DGAT2 and Rab1b activity mutants, dominant-negative Rab1b overexpression, LD formation assay, in vitro DAG recruitment assay, Warburg Micro syndrome mouse fibroblast model Science advances Medium 38809969
2025 ATG2A transfers DAG from the ER to lipid droplets and this DAG transfer recruits DGAT2 to the LD surface for TAG synthesis and LD expansion; in ATG2A deficiency, DGAT2 fails to relocate to LDs. In vitro, DAG directly recruits DGAT2 to LDs. ATG2A and DGAT2 act synergistically for LD growth. ATG2A knockdown/knockout, in vitro lipid transfer reconstitution, DAG-mediated DGAT2 recruitment to artificial LDs, DGAT2 inhibitor studies, live-cell imaging Nature structural & molecular biology High 41249819
2025 Amyloid-β exposure induces DGAT2-dependent lipid droplet formation in microglia, converting free fatty acids to triacylglycerols; DGAT2 expression is increased in 5xFAD mouse and human AD brains. Pharmacological DGAT2 inhibition improves microglial Aβ phagocytosis and reduces plaque load and neuronal damage in 5xFAD mice. Lipidomic analysis of Aβ-treated microglia, DGAT2 KO/pharmacological inhibition, Aβ phagocytosis assay, plaque load quantification in 5xFAD mouse model Immunity High 40393454
2010 Chronic alcohol feeding upregulates DGAT2 gene and protein expression in liver via suppression of MEK/ERK1/2 signaling, and this is mechanistically linked through disrupted methionine metabolism (reduced SAM/SAH ratio); restoring SAM/SAH with betaine supplementation alleviates ERK1/2 inhibition and attenuates DGAT2 upregulation. In vivo alcohol feeding model, MEK/ERK inhibitor treatment in HepG2 cells, betaine supplementation, gene expression analysis, TG quantification Journal of lipid research Medium 20739640
2014 FAAH overexpression inhibits DGAT2 expression and TG synthesis; a loss-of-function FAAH variant (R315I) eliminates this inhibitory effect, demonstrating that FAAH functions upstream of DGAT2 to regulate TG biosynthesis. In vitro overexpression of FAAH and DGAT2 in cell lines, TG synthesis assay, exome sequencing plus functional validation of FAAH R315I mutation Endocrine Medium 28243972
2004 DGAT2 mRNA expression in white adipose tissue is regulated by central leptin action; intracerebroventricular leptin infusion reduces DGAT2 expression in WAT of IRS-2-deficient and ob/ob mice independently of DGAT1, placing DGAT2 downstream of central leptin/IRS-2 signaling in adipose triglyceride metabolism. IRS-2 KO and ob/ob mouse models, intracerebroventricular leptin infusion, RT-PCR for DGAT1/DGAT2 mRNA, 3T3-L1 adipocyte hypertrophy model The Journal of biological chemistry Medium 15550388

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2001 Cloning of DGAT2, a second mammalian diacylglycerol acyltransferase, and related family members. The Journal of biological chemistry 613 11481335
2003 Lipopenia and skin barrier abnormalities in DGAT2-deficient mice. The Journal of biological chemistry 478 14668353
2006 Tung tree DGAT1 and DGAT2 have nonredundant functions in triacylglycerol biosynthesis and are localized to different subdomains of the endoplasmic reticulum. The Plant cell 392 16920778
2008 The endoplasmic reticulum enzyme DGAT2 is found in mitochondria-associated membranes and has a mitochondrial targeting signal that promotes its association with mitochondria. The Journal of biological chemistry 329 19049983
2007 Suppression of diacylglycerol acyltransferase-2 (DGAT2), but not DGAT1, with antisense oligonucleotides reverses diet-induced hepatic steatosis and insulin resistance. The Journal of biological chemistry 315 17526931
2001 DGAT2 is a new diacylglycerol acyltransferase gene family: purification, cloning, and expression in insect cells of two polypeptides from Mortierella ramanniana with diacylglycerol acyltransferase activity. The Journal of biological chemistry 260 11481333
2005 Antisense oligonucleotide reduction of DGAT2 expression improves hepatic steatosis and hyperlipidemia in obese mice. Hepatology (Baltimore, Md.) 245 16001399
2004 Niacin noncompetitively inhibits DGAT2 but not DGAT1 activity in HepG2 cells. Journal of lipid research 174 15258194
2006 Colocalization of SCD1 and DGAT2: implying preference for endogenous monounsaturated fatty acids in triglyceride synthesis. Journal of lipid research 168 16751624
2019 The triglyceride synthesis enzymes DGAT1 and DGAT2 have distinct and overlapping functions in adipocytes. Journal of lipid research 138 30936184
2006 Identification and functional expression of a type 2 acyl-CoA:diacylglycerol acyltransferase (DGAT2) in developing castor bean seeds which has high homology to the major triglyceride biosynthetic enzyme of fungi and animals. Phytochemistry 134 17084870
2010 DGAT1, DGAT2 and PDAT expression in seeds and other tissues of epoxy and hydroxy fatty acid accumulating plants. Lipids 112 20101470
2002 Concerted elevation of acyl-coenzyme A:diacylglycerol acyltransferase (DGAT) activity through independent stimulation of mRNA expression of DGAT1 and DGAT2 by carbohydrate and insulin. Biochemical and biophysical research communications 105 12413942
2013 Hepatic triacylglycerol synthesis and secretion: DGAT2 as the link between glycaemia and triglyceridaemia. The Biochemical journal 96 23489367
2005 Identification of two novel human acyl-CoA wax alcohol acyltransferases: members of the diacylglycerol acyltransferase 2 (DGAT2) gene superfamily. The Journal of biological chemistry 90 15671038
2014 Diacylglycerol acyltransferase-2 (DGAT2) and monoacylglycerol acyltransferase-2 (MGAT2) interact to promote triacylglycerol synthesis. The Journal of biological chemistry 67 25164810
2009 The DGAT2 gene is a candidate for the dissociation between fatty liver and insulin resistance in humans. Clinical science (London, England : 1979) 65 18980578
2010 Identification and characterization of an acyl-CoA:diacylglycerol acyltransferase 2 (DGAT2) gene from the microalga O. tauri. Plant physiology and biochemistry : PPB 63 20400321
2018 DGAT2 Inhibition Alters Aspects of Triglyceride Metabolism in Rodents but Not in Non-human Primates. Cell metabolism 62 29706567
2025 Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer's disease. Immunity 56 40393454
2020 Oil-Producing Metabolons Containing DGAT1 Use Separate Substrate Pools from those Containing DGAT2 or PDAT. Plant physiology 52 32732347
2021 Lipid Droplet Biosynthesis Impairment through DGAT2 Inhibition Sensitizes MCF7 Breast Cancer Cells to Radiation. International journal of molecular sciences 51 34576263
2013 Identification and characterization of PtDGAT2B, an acyltransferase of the DGAT2 acyl-coenzyme A: diacylglycerol acyltransferase family in the diatom Phaeodactylum tricornutum. FEBS letters 51 23337871
2010 Involvement and mechanism of DGAT2 upregulation in the pathogenesis of alcoholic fatty liver disease. Journal of lipid research 51 20739640
2010 The olive DGAT2 gene is developmentally regulated and shares overlapping but distinct expression patterns with DGAT1. Journal of experimental botany 50 20870930
2004 Expression of DGAT2 in white adipose tissue is regulated by central leptin action. The Journal of biological chemistry 48 15550388
2014 Function and localization of the Arabidopsis thaliana diacylglycerol acyltransferase DGAT2 expressed in yeast. PloS one 47 24663078
2009 Fenofibrate ameliorates diabetic and dyslipidemic profiles in KKAy mice partly via down-regulation of 11beta-HSD1, PEPCK and DGAT2. Comparison of PPARalpha, PPARgamma, and liver x receptor agonists. European journal of pharmacology 44 19245804
2003 A novel diacylglycerol acyltransferase (DGAT2) is decreased in human psoriatic skin and increased in diabetic mice. Biochemical and biophysical research communications 44 14521909
2016 DGAT2 Mutation in a Family with Autosomal-Dominant Early-Onset Axonal Charcot-Marie-Tooth Disease. Human mutation 42 26786738
2024 The role of DGAT1 and DGAT2 in regulating tumor cell growth and their potential clinical implications. Journal of translational medicine 40 38500157
2018 In silico characterization and expression profiling of the diacylglycerol acyltransferase gene family (DGAT1, DGAT2, DGAT3 and WS/DGAT) from oil palm, Elaeis guineensis. Plant science : an international journal of experimental plant biology 36 30107884
2021 An RNAi therapeutic targeting hepatic DGAT2 in a genetically obese mouse model of nonalcoholic steatohepatitis. Molecular therapy : the journal of the American Society of Gene Therapy 34 34774753
2022 DGAT2 Inhibition Potentiates Lipid Droplet Formation To Reduce Cytotoxicity in APOL1 Kidney Risk Variants. Journal of the American Society of Nephrology : JASN 31 35232775
2007 Mutation screen and association studies in the diacylglycerol O-acyltransferase homolog 2 gene (DGAT2), a positional candidate gene for early onset obesity on chromosome 11q13. BMC genetics 27 17477860
2020 Involvement of CYP2E1-ROS-CD36/DGAT2 axis in the pathogenesis of VPA-induced hepatic steatosis in vivo and in vitro. Toxicology 26 33007364
2024 The translational potential of miR-26 in atherosclerosis and development of agents for its target genes ACC1/2, COL1A1, CPT1A, FBP1, DGAT2, and SMAD7. Cardiovascular diabetology 23 38195542
2015 Identification of a 13 bp indel polymorphism in the 3'-UTR of DGAT2 gene associated with backfat thickness and lean percentage in pigs. Gene 23 26407871
2022 Overexpression of DGAT2 Stimulates Lipid Droplet Formation and Triacylglycerol Accumulation in Bovine Satellite Cells. Animals : an open access journal from MDPI 22 35883393
2017 Characterization and Functional Analysis of a Type 2 Diacylglycerol Acyltransferase (DGAT2) Gene from Oil Palm (Elaeis guineensis Jacq.) Mesocarp in Saccharomyces cerevisiae and Transgenic Arabidopsis thaliana. Frontiers in plant science 21 29089956
2019 DGAT2 partially compensates for lipid-induced ER stress in human DGAT1-deficient intestinal stem cells. Journal of lipid research 19 31315900
2015 Effects of tung oilseed FAD2 and DGAT2 genes on unsaturated fatty acid accumulation in Rhodotorula glutinis and Arabidopsis thaliana. Molecular genetics and genomics : MGG 19 25754996
2014 Characterisation of DGAT1 and DGAT2 from Jatropha curcas and their functions in storage lipid biosynthesis. Functional plant biology : FPB 18 32480992
2018 Hepatic VLDL secretion: DGAT1 determines particle size but not particle number, which can be supported entirely by DGAT2. Journal of lipid research 17 30397187
2015 Identification of DGAT2 Inhibitors Using Mass Spectrometry. Journal of biomolecular screening 17 26403520
2011 Isolation, mapping, SNP detection and association with backfat traits of the porcine CTNNBL1 and DGAT2 genes. Molecular biology reports 17 21997828
2003 Genomic organization of the DGAT2/MOGAT gene family in cattle (Bos taurus) and other mammals. Cytogenetic and genome research 17 14970677
2020 Enhanced triacylglycerol production in oleaginous microalga Neochloris oleoabundans by co-overexpression of lipogenic genes: Plastidial LPAAT1 and ER-located DGAT2. Journal of bioscience and bioengineering 16 33069576
2021 CD36 and DGAT2 facilitate the lipid-lowering effect of chitooligosaccharides via fatty acid intake and triglyceride synthesis signaling. Food & function 15 34351342
2018 Association of DGAT2 gene polymorphisms with carcass and meat quality traits in domestic pigeons (Columba livia). British poultry science 15 29207879
2012 Rescue of Mtp siRNA-induced hepatic steatosis by DGAT2 siRNA silencing. Journal of lipid research 15 22355095
2024 The role of DGAT1 and DGAT2 in tumor progression via fatty acid metabolism: A comprehensive review. International journal of biological macromolecules 13 39154689
2024 DGAT1 and DGAT2 Inhibitors for Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Management: Benefits for Their Single or Combined Application. International journal of molecular sciences 13 39201759
2022 Expression of DGAT2 Gene and Its Associations With Intramuscular Fat Content and Breast Muscle Fiber Characteristics in Domestic Pigeons (Columba livia). Frontiers in veterinary science 13 35754541
2017 Genetic interaction of DGAT2 and FAAH in the development of human obesity. Endocrine 13 28243972
2020 CTRP12 inhibits triglyceride synthesis and export in hepatocytes by suppressing HNF-4α and DGAT2 expression. FEBS letters 12 32749667
2019 Resveratrol protects against hepatic insulin resistance in a rat's model of non-alcoholic fatty liver disease by down-regulation of GPAT-1 and DGAT2 expression and inhibition of PKC membranous translocation. Clinical and experimental pharmacology & physiology 12 30773673
2015 Dietary Omega-3 Fatty Acids Prevented Adipocyte Hypertrophy by Downregulating DGAT-2 and FABP-4 in a Sex-Dependent Fashion. Lipids 12 26662277
2014 Dictyostelium discoideum Dgat2 can substitute for the essential function of Dgat1 in triglyceride production but not in ether lipid synthesis. Eukaryotic cell 12 24562909
2024 Rab1b facilitates lipid droplet growth by ER-to-lipid droplet targeting of DGAT2. Science advances 11 38809969
2021 DGAT2 stability is increased in response to DGAT1 inhibition in gene edited HepG2 cells. Biochimica et biophysica acta. Molecular and cell biology of lipids 11 34116261
2019 Tangduqing Granules Attenuate Insulin Resistance and Abnormal Lipid Metabolism through the Coordinated Regulation of PPARγ and DGAT2 in Type 2 Diabetic Rats. Journal of diabetes research 11 31019978
2023 Preferential lipolysis of DGAT1 over DGAT2 generated triacylglycerol in Huh7 hepatocytes. Biochimica et biophysica acta. Molecular and cell biology of lipids 10 37516308
2015 Treatment of rats with Jiangzhi Capsule improves liquid fructose-induced fatty liver: modulation of hepatic expression of SREBP-1c and DGAT-2. Journal of translational medicine 10 26031670
2024 Diurnal expression of Dgat2 induced by time-restricted feeding maintains cardiac health in the Drosophila model of circadian disruption. Aging cell 9 38616316
2023 Overexpression of DGAT2 Regulates the Differentiation of Bovine Preadipocytes. Animals : an open access journal from MDPI 9 37048451
2021 Low expression of miR-19a-5p is associated with high mRNA expression of diacylglycerol O-acyltransferase 2 (DGAT2) in hybrid tilapia. Genomics 9 34022348
2019 Tissue Expression and Variation of the DGAT2 Gene and Its Effect on Carcass and Meat Quality Traits in Yak. Animals : an open access journal from MDPI 9 30769898
2011 The effect of excess cobalt on milk fatty acid profiles and transcriptional regulation of SCD, FASN, DGAT1 and DGAT2 in the mammary gland of lactating dairy cows. Journal of animal physiology and animal nutrition 9 21895781
2025 Antisense oligonucleotide DGAT-2 inhibitor, ION224, for metabolic dysfunction-associated steatohepatitis (ION224-CS2): results of a 51-week, multicentre, randomised, double-blind, placebo-controlled, phase 2 trial. Lancet (London, England) 8 40849139
2020 Pluripotent Stem Cell-Derived Hepatocytes Phenotypic Screening Reveals Small Molecules Targeting the CDK2/4-C/EBPα/DGAT2 Pathway Preventing ER-Stress Induced Lipid Accumulation. International journal of molecular sciences 8 33334026
2018 Mechanistic Characterization of Long Residence Time Inhibitors of Diacylglycerol Acyltransferase 2 (DGAT2). Biochemistry 8 30422629
2016 Cutinsomes and cuticle enzymes GPAT6 and DGAT2 seem to travel together from a lipotubuloid metabolon (LM) to extracellular matrix of O. umbellatum ovary epidermis. Micron (Oxford, England : 1993) 6 27088229
2014 Urokinase-type plasminogen activator (uPA) stimulates triglyceride synthesis in Huh7 hepatoma cells via p38-dependent upregulation of DGAT2. Atherosclerosis 6 25244504
2014 Identification and characterization of a type-2 diacylglycerol acyltransferase (DGAT2) from Rhodosporidium diobovatum. Antonie van Leeuwenhoek 6 25294723
2025 ATG2A-mediated DAG transfer recruits DGAT2 for lipid droplet growth. Nature structural & molecular biology 5 41249819
2023 Role of Dgat2 in Glucose Uptake and Fatty Acid Metabolism in C2C12 Skeletal Myotubes. Journal of microbiology and biotechnology 5 37644753
2016 Expressional profiling of prostate cancer risk SNPs at 11q13.5 identifies DGAT2 as a new target gene. Genes, chromosomes & cancer 5 27113481
2025 Regulation of lipid dysmetabolism and neuroinflammation progression linked with Alzheimer's disease through modulation of Dgat2. bioRxiv : the preprint server for biology 4 40027815
2024 The transcription factor MYB1 activates DGAT2 transcription to promote triacylglycerol accumulation in sacha inchi (Plukenetia volubilis L.) leaves under heat stress. Plant physiology and biochemistry : PPB 4 38503190
2024 Apolipoprotein E Induces Lipid Accumulation Through Dgat2 That Is Prevented with Time-Restricted Feeding in Drosophila. Genes 4 39596576
2023 Newly identified essential amino acids affecting peanut (Arachis hypogaea L.) DGAT2 enzyme activity. Heliyon 4 36711321
2023 Dual targeting of hepatocyte DGAT2 and stellate cell FASN alleviates nonalcoholic steatohepatitis in mice. bioRxiv : the preprint server for biology 4 37461560
2023 Characterization of thraustochytrid-specific sterol O-acyltransferase: modification of DGAT2-like enzyme to increase the sterol production in Aurantiochytrium limacinum mh0186. Applied and environmental microbiology 4 37874286
2020 Identification, molecular characteristics, and tissue differential expression of DGAT2 full-CDS cDNA sequence in Binglangjiang buffalo (Bubalus bubalis). Archives animal breeding 4 32232120
2012 FAD2-DGAT2 genes coexpressed in endophytic Aspergillus fumigatus derived from tung oilseeds. TheScientificWorldJournal 4 22919314
2008 [Association of polymorphisms of DGAT2 gene with growth traits in Jiaxian red cattle]. Yi chuan = Hereditas 4 18332002
2022 Corrigendum: Expression of DGAT2 gene and its associations with intramuscular fat content and breast muscle fiber characteristics in domestic pigeons (Columba livia). Frontiers in veterinary science 3 36187813
2019 Identification and function analysis of a type 2 diacylglycerol acyltransferase (DGAT2) from the endosperm of coconut (Cocos nucifera L.). Gene 3 30928362
2025 DGAT2 reduction and lipid dysregulation drive psoriasis development in keratinocyte-specific SPRY1-deficient mice. JCI insight 2 40694426
2024 DGAT2 Plays a Crucial Role to Control ESRRA-PROX1 Transcriptional Network to Maintain Hepatic Mitochondrial Sustainability. Diabetes & metabolism journal 2 38644620
2021 DGAT2-MOGAT2 SNPs and Gene-Environment Interactions on Serum Lipid Profiles and the Risk of Ischemic Stroke. Frontiers in cardiovascular medicine 2 34901200
2019 The Amphibian Diacylglycerol O-acyltransferase 2 (DGAT2): a 'paleo-protein' with Conserved Function but Unique Folding. The protein journal 2 30697667
2007 [Polymorphisms of DGAT2 gene and its associations with several growth traits in Nanyang cattle]. Yi chuan = Hereditas 2 17681922
2026 Regulation of Lipid Dysmetabolism and Neuroinflammation Progression Linked With Alzheimer's Disease Through Modulation of Dgat2. Aging cell 1 41832772
2025 miR-10c Targets dgat2 and Affects the Expression of Genes Involved in Fatty Acid and Triglyceride Metabolism in Oreochromis niloticus Under Heat Stress. International journal of molecular sciences 1 41096982
2022 The Postnatal Resolution of Developmental Toxicity Induced by Pharmacological Diacylglycerol Acyltransferase 2 (DGAT2) Inhibition During Gestation in Rats. Toxicological sciences : an official journal of the Society of Toxicology 1 35866640
2026 Inflammation promotes hepatic but not adipose tissue DGAT2 expression and triglyceride synthesis in MAFLD mice. Pathology, research and practice 0 41814114
2025 Effect of Varying Degrees of Hepatic Impairment on the Pharmacokinetics of Ervogastat, a Diacylglycerol Acyltransferase 2 (DGAT2) Inhibitor, and Clesacostat, an Acetyl-CoA Carboxylase (ACC) Inhibitor. Journal of clinical pharmacology 0 40996355
2008 [Research progress on diacylgycerol acyltransferase 2 (DGAT2) gene]. Yi chuan = Hereditas 0 18331995