Affinage

CDS2

Phosphatidate cytidylyltransferase 2 · UniProt O95674

Length
445 aa
Mass
51.4 kDa
Annotated
2026-04-28
72 papers in source corpus 18 papers cited in narrative 18 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

CDS2 is an integral endoplasmic reticulum membrane enzyme that catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), serving as the committed step for phosphatidylinositol (PI) resynthesis during phospholipase C signaling. CDS2 preferentially channels arachidonoyl-enriched PA species toward PI synthesis and is specifically required to sustain the PI cycle during agonist-stimulated PLC activation; its loss causes PA, diacylglycerol, and triglyceride accumulation, giant lipid droplet formation via DGAT2/GPAT4 recruitment, and calcium homeostasis defects (PMID:35712788, PMID:39312194, PMID:31548309, PMID:26946540). CDS2 localizes to mitochondria-associated membranes where it supports mitochondrial phosphatidylethanolamine levels, and liver-specific CDS2 deletion causes hepatic steatosis, inflammation, and fibrosis (PMID:36546079). CDS2 is a robust synthetic lethal partner of its paralog CDS1, such that CDS2 loss in CDS1-low cancers disrupts phosphoinositide homeostasis and triggers apoptosis in a catalytic-activity-dependent manner (PMID:40615675, PMID:40615674).

Mechanistic history

Synthesis pass · year-by-year structured walk · 11 steps
  1. 1997 High

    Identification of CDS2 as a second mammalian CDP-diacylglycerol synthase established that PA-to-CDP-DAG conversion is catalyzed by two distinct isoforms, raising the question of whether they serve redundant or specialized roles.

    Evidence cDNA cloning from EST database, expression in COS-7 cells with in vitro enzyme activity assay

    PMID:9407135

    Open questions at the time
    • No isoform-specific substrates or regulation identified
    • Overexpression did not limit PI content, leaving physiological rate-limiting role unclear
  2. 2003 High

    Demonstration that PPARα activates CDS2 transcription and CDS2-dependent cardiolipin biosynthesis in heart tissue established the first transcriptional regulator of CDS2 and linked it to cardiac mitochondrial lipid metabolism.

    Evidence Clofibrate treatment of wild-type vs. PPARα-null mice with CDS-2 enzyme activity and mRNA quantification

    PMID:14594999

    Open questions at the time
    • Whether PPARα directly binds CDS2 promoter or acts indirectly was not resolved
    • Cardiac-specific role versus systemic relevance unclear
  3. 2009 Medium

    CDS2 knockdown disrupted cardiolipin biosynthesis and abolished mitomycin C-induced p53 mitochondrial translocation, revealing CDS2 as required for a stress-activated apoptotic signaling step.

    Evidence shRNA knockdown in HepG2/HEK293T cells with mitochondrial fractionation and immunoblot

    PMID:20126473

    Open questions at the time
    • Single study without independent replication
    • Whether cardiolipin itself or downstream lipid changes mediate p53 translocation was not distinguished
  4. 2016 High

    CDS2 depletion was shown to cause giant lipid droplet formation and ER phosphatidic acid accumulation, establishing that CDS2 controls PA flux away from neutral lipid storage pathways.

    Evidence siRNA knockdown with fluorescence microscopy and lipidomic analysis of PA species

    PMID:26946540

    Open questions at the time
    • Mechanism by which elevated PA drives giant LD formation not yet defined
    • CDS1 vs CDS2 specificity in LD phenotype not resolved in this study
  5. 2017 High

    Definitive ER localization of CDS1/CDS2 was established by showing that mitochondrial CDP-DAG synthase activity belongs to TAMM41, not CDS2, resolving a longstanding compartmental ambiguity.

    Evidence Subcellular fractionation, siRNA knockdown of TAMM41, cardiolipin and oxygen consumption measurements in H9c2 cells

    PMID:29253589

    Open questions at the time
    • Does not address CDS2 presence at mitochondria-associated membranes (later shown)
  6. 2018 Medium

    The p53–SIRT6 complex was shown to directly bind CDS2 promoter and recruit RNA polymerase II, identifying a second transcriptional axis controlling CDS2 expression relevant to cardiolipin metabolism.

    Evidence Co-immunoprecipitation and chromatin immunoprecipitation with reporter assays

    PMID:30237540

    Open questions at the time
    • Single laboratory study
    • Physiological contexts beyond palmitate stress not tested
  7. 2019 High

    Two key advances distinguished CDS2 from CDS1: (1) CDS2 specifically sustains PI resynthesis during PLC signaling by preferentially routing arachidonoyl-PA toward PI, and (2) CDS2 loss uniquely promotes DGAT2/GPAT4 recruitment to lipid droplets, a phenotype rescued by depleting these enzymes.

    Evidence Stable isotope tracing with mass spectrometry for PI species (CDS2 vs CDS1 knockdown); CRISPR KO plus double-knockdown rescue of giant LD phenotype

    PMID:31548309 PMID:35712788

    Open questions at the time
    • Structural basis for CDS2 substrate selectivity toward arachidonoyl-PA unknown
    • Mechanism linking local PA to DGAT2/GPAT4 recruitment not fully defined
  8. 2019 High

    Genetic ablation of CDS2 in zebrafish and mouse endothelium converted VEGFA signaling from pro-angiogenic to pro-regressive through PIP2/PIP3 depletion and FOXO1 activation, revealing CDS2 as a vascular-specific gatekeeper of PI-dependent signaling.

    Evidence Zebrafish cds2 mutant live imaging, conditional mouse CDS2 KO in retinal and tumor vasculature, PIP2/PIP3 measurement

    PMID:31501519

    Open questions at the time
    • Whether other PI-dependent pathways (e.g., mTOR) are similarly affected in endothelium not tested
    • Contribution of CDS1 compensation in vivo not quantified
  9. 2021 High

    Liver-specific CDS2 deletion caused NASH-like pathology; CDS2 enrichment at mitochondria-associated membranes and rescue by PISD overexpression placed CDS2 upstream of mitochondrial PE synthesis, linking ER CDP-DAG production to mitochondrial membrane lipid homeostasis.

    Evidence Liver-specific Cds2 KO mice, MAM fractionation, lipidomics, PISD genetic rescue

    PMID:36546079

    Open questions at the time
    • How CDP-DAG generated at ER/MAMs feeds into mitochondrial PE synthesis pathway is mechanistically unclear
    • Whether CDS1 compensates in other tissues not addressed
  10. 2024 High

    Isotope tracing in primary CDS2-KO macrophages showed that CDS2 is dispensable for basal PI synthesis rates but essential to sustain enhanced PI resynthesis during PLC stimulation, and revealed CDS2 loss causes calcium dysregulation independent of PLC.

    Evidence CRISPR KO in primary macrophages, dual stable isotope labeling, GPCR-stimulated PLC assays, calcium imaging

    PMID:39312194

    Open questions at the time
    • Mechanism of PLC-independent calcium defect not identified
    • Whether findings extend to non-macrophage immune cells unclear
  11. 2025 High

    Two independent genome-wide CRISPR screens identified CDS2 as a robust synthetic lethal target in CDS1-low cancers; the interaction depends on CDS2 catalytic activity, operates in vivo, and is accompanied by broad lipid homeostasis disruption including cholesterol ester and triglyceride accumulation.

    Evidence Genome-wide CRISPR screens across uveal melanoma and pan-cancer cell lines, catalytic mutant rescue, CDS1 re-expression rescue, in vivo tumor models, lipidomics

    PMID:40615674 PMID:40615675

    Open questions at the time
    • No therapeutic agent targeting CDS2 yet developed
    • Mechanisms of downstream apoptosis induction beyond lipid imbalance not fully delineated

Open questions

Synthesis pass · forward-looking unresolved questions
  • The structural basis for CDS2's preference for arachidonoyl-PA substrates, the mechanism by which CDS2-derived CDP-DAG at MAMs supports mitochondrial PE, and whether CDS2 inhibition can be therapeutically exploited in CDS1-low cancers remain unresolved.
  • No crystal or cryo-EM structure of CDS2
  • No small-molecule CDS2 inhibitor reported
  • Precise lipid transfer mechanism from ER/MAM CDP-DAG pool to mitochondrial PE synthesis unknown

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0016740 transferase activity 5
Localization
GO:0005783 endoplasmic reticulum 4 GO:0005811 lipid droplet 2 GO:0005739 mitochondrion 1
Pathway
R-HSA-1430728 Metabolism 6 R-HSA-162582 Signal Transduction 3 R-HSA-5357801 Programmed Cell Death 2
Partners
CDS1DGAT2GPAT4MBOAT7SIRT6TP53

Evidence

Reading pass · 18 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1997 CDS2 encodes a second human CDP-diacylglycerol synthase (CDS) isoform that converts phosphatidic acid to CDP-diacylglycerol; its existence was inferred from EST database screening alongside CDS1, with both enzymes localized to the ER and their overexpression shown not to be rate-limiting for cellular phosphatidylinositol content. cDNA cloning from EST database, expression in COS-7 cells, in vitro enzyme activity assay, Northern blot The Journal of biological chemistry High 9407135
1998 Human CDS2 gene was cloned, sequenced, and mapped to chromosome 20p13 by radiation hybrid panel mapping and FISH; the encoded protein is homologous to Drosophila CDP-diacylglycerol synthase required for phototransduction. cDNA cloning, radiation hybrid mapping, fluorescence in situ hybridization (FISH) Genomics High 9806839
1999 CDS2 full-length cDNA was isolated and shown to encode a protein 64.4% identical to Drosophila CDS; in situ hybridization showed Cds2 is highly expressed in differentiating neuroblasts of the neural retina and CNS during embryonic mouse development but absent from adult retina. cDNA isolation, sequence analysis, RNA in situ hybridization on mouse tissue sections Genomics High 9889000
2003 PPARα activation in mouse heart in vivo upregulates CDS-2 activity and mRNA levels and stimulates cardiolipin de novo biosynthesis; this regulation was absent in PPARα-null mice, placing CDS2 downstream of PPARα in cardiac cardiolipin synthesis. Clofibrate treatment of wild-type and PPARα-null mice, CDS-2 enzyme activity assay, mRNA quantification, cardiolipin biosynthesis assay Journal of lipid research High 14594999
2005 Murine Cds2 (and Cds1) proteins were shown by transient transfection with epitope-tagged constructs to localize to the endoplasmic reticulum; Cds2 exhibits ubiquitous expression while Cds1 is restricted, and the two proteins are 73% identical. Fluorescence microscopy of epitope-tagged proteins in transiently transfected cells, RT-PCR expression analysis, FISH chromosomal mapping Gene Medium 16023307
2009 CDS-2 shRNA knockdown in HepG2/HEK293T cells disrupted cardiolipin biosynthesis and abolished mitomycin C-induced mitochondrial translocation of p53, demonstrating that CDS2-dependent cardiolipin synthesis is required for p53 mitochondrial localization and its downstream regulation of Bcl-xL and Bcl-2. shRNA knockdown, immunoblot fractionation of mitochondria, cardiolipin biosynthesis disruption assay Neoplasia Medium 20126473
2009 In FATP-1-overexpressing HEK293 cells, CDS-2 mRNA expression and CDS enzyme activity were reduced, correlating with decreased cardiolipin synthesis; in vitro CDS activity was inhibited by exogenous oleoyl-CoA, suggesting FATP-1 regulates cardiolipin biosynthesis through CDS-2. siRNA knockdown and overexpression of FATP-1, CDS enzyme activity assay, mRNA quantification, radiolabeled glycerol incorporation into cardiolipin, in vitro CDS activity with oleoyl-CoA Biochimica et biophysica acta Medium 19523918
2017 CDS1 and CDS2 are integral membrane proteins of the ER, while the mitochondrial CDP-diacylglycerol synthase activity previously attributed to CDS1 was traced to the peripheral mitochondrial protein TAMM41; TAMM41 knockdown reduced mitochondrial CDS activity, cardiolipin levels, and oxygen consumption. Subcellular fractionation, immunoblot, siRNA knockdown of TAMM41, cardiolipin quantification, oxygen consumption measurement, differentiation of H9c2 cells Biochimica et biophysica acta. Molecular and cell biology of lipids High 29253589
2016 Knockdown of CDS2 (or CDS1) in cultured mammalian cells causes formation of giant/supersized lipid droplets and increases phosphatidic acid levels in the ER; CDS2 depletion had a moderate inhibitory effect on 3T3-L1 adipocyte differentiation. siRNA knockdown, fluorescence microscopy of lipid droplets, lipidomic analysis of PA species, 3T3-L1 differentiation assay Journal of lipid research High 26946540
2018 p53 physically interacts with SIRT6 in vitro and in vivo, and the complex binds promoters of CDS1 and CDS2 to enhance their transcription; SIRT6 acts as a co-activator recruiting RNA polymerase II to CDS2 promoter, thereby regulating cardiolipin de novo biosynthesis. Co-immunoprecipitation (in vitro and in vivo), chromatin immunoprecipitation (ChIP), reporter assays, palmitic acid treatment Cell death & disease Medium 30237540
2019 Genetic ablation of CDS2 in zebrafish and mouse endothelium switches VEGFA signaling from pro-angiogenic to pro-regressive; mechanistically, VEGFA stimulation in CDS2-null endothelium reduces PIP2 availability, causing PIP3 deficiency and FOXO1 activation that triggers vessel regression. Zebrafish cds2 mutant live imaging, conditional mouse CDS2 knockout (retina and tumor models), PIP2/PIP3 measurements, FOXO1 activation assay Cell research High 31501519
2019 CDS2, but not CDS1, contributes to increased PI resynthesis during PLC activation; CDS2 preferentially routes arachidonoyl-enriched PA species toward PI synthesis, contributing to maintenance of the 38:4 fatty acid profile of phosphoinositides during agonist stimulation. Stable isotope labeling (13C-glucose), mass spectrometry of PI species, siRNA knockdown of CDS2 vs CDS1, agonist-stimulated PLC assays EMBO reports High 35712788
2019 CDS2 deficiency (but not CDS1 deficiency) promotes LD association of DGAT2 and GPAT4 and impairs initial LD maturation; reducing DGAT2 or GPAT4 expression rescued the giant LD phenotype in CDS2-deficient cells but not CDS1-deficient cells, revealing distinct mechanisms for CDS1 vs CDS2 in LD growth. siRNA knockdown, CRISPR/Cas9 knockout, fluorescence microscopy, immunological localization of DGAT2/GPAT4 at LDs The Journal of biological chemistry High 31548309
2021 Liver-specific CDS2 deficiency in mice caused hepatic steatosis, inflammation, and fibrosis; CDS2 is enriched in mitochondria-associated membranes (MAMs) and its loss impairs mitochondrial function and decreases mitochondrial PE levels; overexpression of PISD (phosphatidylserine decarboxylase) rescued the NASH-like phenotype, placing CDS2 upstream of mitochondrial PE synthesis. Liver-specific Cds2 knockout mice, MAM fractionation, mitochondrial function assays, lipidomics, PISD overexpression rescue, PPARα agonist treatment Science bulletin High 36546079
2024 In primary mouse macrophages, CDS2 deletion causes modest changes in steady-state PI but substantially increases PA, CDP-DG, DG, and TG; stable isotope labeling showed CDS2 loss minimally reduces de novo PI synthesis rate but substantially increases de novo PA synthesis from G3P. Under sustained PLC stimulation, CDS2-deficient macrophages cannot maintain enhanced PI synthesis ('PI cycle'), causing PI depletion; CDS2 deficiency also causes calcium homeostasis defects independent of PLC activation. CRISPR/Cas9 knockout in primary macrophages, stable isotope labeling (13C6-glucose, 13C6D7-glucose), lipidomics, GPCR-stimulated PLC assays, calcium imaging The Biochemical journal High 39312194
2025 CDS2 is a synthetic lethal target in the context of low CDS1 expression in uveal melanoma and multiple tumor types; CDS2 knockout disrupts phosphoinositide synthesis and increases cellular apoptosis; re-expression of CDS1 rescues the cell fitness defect; synthetic lethality depends on CDS2 catalytic activity and operates in vivo. Genome-wide CRISPR-Cas9 single and paired-gene screens in 10 uveal melanoma cell lines, CDS1 re-expression rescue, in vivo tumor models, pan-cancer data analysis Nature genetics High 40615675
2025 CDS2 essentiality in mesenchymal-like (CDS1-low) cancers is accompanied by disruption of lipid homeostasis including accumulation of cholesterol esters and triglycerides; synthetic lethality is driven by CDS2 dosage and requires catalytic activity; no common CRISPR escape mechanism was identified, indicating robustness of the interaction. Genome-wide CRISPR-Cas9 KO screens in CDS1-negative cancer cells, lipidomics, catalytic mutant rescue experiments Nature genetics High 40615674
2025 Under physiological conditions MBOAT7 interacts with CDS2 at the ER to maintain lipid metabolic homeostasis; CDS2 knockdown or loss of function triggers MBOAT7 translocation from ER to ER-LD contact sites in a RAB1-dependent manner, where it inhibits DGAT2-mediated LD growth and promotes lipolysis. Co-immunoprecipitation, fluorescence microscopy of MBOAT7 localization, CDS2 knockdown, RAB1 dependency assay, LD size measurement, lipolysis assay bioRxivpreprint Medium bio_10.1101_2025.08.26.672501

Source papers

Stage 0 corpus · 72 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2001 Performance of comorbidity scores to control for confounding in epidemiologic studies using claims data. American journal of epidemiology 623 11682368
2013 MMAPPR: mutation mapping analysis pipeline for pooled RNA-seq. Genome research 280 23299975
2009 Abscisic acid has a key role in modulating diverse plant-pathogen interactions. Plant physiology 236 19571312
2006 Identification of MglA-regulated genes reveals novel virulence factors in Francisella tularensis. Infection and immunity 139 17000729
2012 High levels of RNA-editing site conservation amongst 15 laboratory mouse strains. Genome biology 135 22524474
2000 Evidence for the secretion of Chlamydia trachomatis CopN by a type III secretion mechanism. Molecular microbiology 132 11123678
2019 Phosphatidylinositol synthesis at the endoplasmic reticulum. Biochimica et biophysica acta. Molecular and cell biology of lipids 101 31173893
1997 The role of CDP-diacylglycerol synthetase and phosphatidylinositol synthase activity levels in the regulation of cellular phosphatidylinositol content. The Journal of biological chemistry 100 9407135
2008 Cardiolipin biosynthesis and remodeling enzymes are altered during development of heart failure. Journal of lipid research 91 19001357
2020 CDP-Diacylglycerol Synthases (CDS): Gateway to Phosphatidylinositol and Cardiolipin Synthesis. Frontiers in cell and developmental biology 84 32117988
2011 Underexpression of miR-224 in methotrexate resistant human colon cancer cells. Biochemical pharmacology 68 21864507
2013 The identification of novel targets of miR-16 and characterization of their biological functions in cancer cells. Molecular cancer 51 23941513
2019 Endothelial CDS2 deficiency causes VEGFA-mediated vascular regression and tumor inhibition. Cell research 46 31501519
2020 Establishment and characterization of NCC-CDS2-C1: a novel patient-derived cell line of CIC-DUX4 sarcoma. Human cell 45 31898195
2020 RNA-Seq based genetic variant discovery provides new insights into controlling fat deposition in the tail of sheep. Scientific reports 45 32782325
2016 CDP-diacylglycerol synthases regulate the growth of lipid droplets and adipocyte development. Journal of lipid research 42 26946540
2005 Isolation and characterization of murine Cds (CDP-diacylglycerol synthase) 1 and 2. Gene 40 16023307
2017 Mitochondrial CDP-diacylglycerol synthase activity is due to the peripheral protein, TAMM41 and not due to the integral membrane protein, CDP-diacylglycerol synthase 1. Biochimica et biophysica acta. Molecular and cell biology of lipids 39 29253589
2008 STAT-3 regulates surfactant phospholipid homeostasis in normal lung and during endotoxin-mediated lung injury. Journal of applied physiology (Bethesda, Md. : 1985) 38 18369093
2006 Interleukin-17 receptor-like gene is a novel antiapoptotic gene highly expressed in androgen-independent prostate cancer. Cancer research 37 16397230
2021 Phospholipid dynamics in ex vivo lung cancer and normal lung explants. Experimental & molecular medicine 36 33408336
2002 Differential expression of cold- and diet-specific genes encoding two carp liver delta 9-acyl-CoA desaturase isoforms. American journal of physiology. Regulatory, integrative and comparative physiology 36 12388470
2013 Extraplastidial cytidinediphosphate diacylglycerol synthase activity is required for vegetative development in Arabidopsis thaliana. The Plant journal : for cell and molecular biology 35 23711240
1999 Identification and characterization of CDS2, a mammalian homolog of the Drosophila CDP-diacylglycerol synthase gene. Genomics 35 9889000
1998 Isolation and chromosomal localization of two human CDP-diacylglycerol synthase (CDS) genes. Genomics 35 9806839
2021 Hepatic CDP-diacylglycerol synthase 2 deficiency causes mitochondrial dysfunction and promotes rapid progression of NASH and fibrosis. Science bulletin 34 36546079
2019 CDP-DAG synthase 1 and 2 regulate lipid droplet growth through distinct mechanisms. The Journal of biological chemistry 32 31548309
2018 p53 cooperates with SIRT6 to regulate cardiolipin de novo biosynthesis. Cell death & disease 32 30237540
2019 Dysregulation of MicroRNA Regulatory Network in Lower Extremities Arterial Disease. Frontiers in genetics 29 31827490
2014 Genome-wide transcriptomic profiling of ramie (Boehmeria nivea L. Gaud) in response to cadmium stress. Gene 29 25550046
2021 Genome-wide analyses reveal population structure and identify candidate genes associated with tail fatness in local sheep from a semi-arid area. Animal : an international journal of animal bioscience 28 33715983
2003 Stimulation of cardiac cardiolipin biosynthesis by PPARalpha activation. Journal of lipid research 28 14594999
2020 Integrated Analysis of lncRNA-miRNA-mRNA ceRNA Network Identified lncRNA EPB41L4A-AS1 as a Potential Biomarker in Non-small Cell Lung Cancer. Frontiers in genetics 27 33193600
2022 Metabolic routing maintains the unique fatty acid composition of phosphoinositides. EMBO reports 24 35712788
2021 Comparison of the effects of synthesis methods of B, N, S, and P-doped carbon dots with high photoluminescence properties on HeLa tumor cells. RSC advances 23 35423683
2008 Prolonged androgen receptor loading onto chromatin and the efficient recruitment of p160 coactivators contribute to androgen-independent growth of prostate cancer cells. The Prostate 20 18780293
2021 Exosomal Circular RNA RNA-seq Profiling and the Carcinogenic Role of Exosomal circ-CYP24A1 in Cutaneous Squamous Cell Carcinoma. Frontiers in medicine 19 34109199
2021 Identification of Novel Gene Signatures using Next-Generation Sequencing Data from COVID-19 Infection Models: Focus on Neuro-COVID and Potential Therapeutics. Frontiers in pharmacology 18 34531741
2010 Translocation of p53 to mitochondria is regulated by its lipid binding property to anionic phospholipids and it participates in cell death control. Neoplasia (New York, N.Y.) 17 20126473
2020 Transcriptome analysis on responses of orchardgrass (Dactylis glomerata L.) leaves to a short term flooding. Hereditas 16 32418541
2010 Rapid decrease in active tension generated by C2C12 myotubes after termination of artificial exercise. Journal of muscle research and cell motility 14 21120590
2023 Transcription Factor GmERF105 Negatively Regulates Salt Stress Tolerance in Arabidopsis thaliana. Plants (Basel, Switzerland) 12 37631217
2019 Prioritization of metabolic genes as novel therapeutic targets in estrogen-receptor negative breast tumors using multi-omics data and text mining. Oncotarget 12 31231467
2020 The Nature and Extent of Plasmid Variation in Chlamydia trachomatis. Microorganisms 11 32155798
2025 The synthetic lethal interaction between CDS1 and CDS2 is a vulnerability in uveal melanoma and across multiple tumor types. Nature genetics 10 40615675
2009 Regulation of cardiolipin biosynthesis by fatty acid transport protein-1 IN HEK 293 cells. Biochimica et biophysica acta 10 19523918
2009 The effects of pyridoxine deficiency and supplementation on hematological profiles, lymphocyte function, and hepatic cytochrome P450 in B6C3F1 mice. Journal of immunotoxicology 10 19637937
2019 Sustained phospholipase C stimulation of H9c2 cardiomyoblasts by vasopressin induces an increase in CDP-diacylglycerol synthase 1 (CDS1) through protein kinase C and cFos. Biochimica et biophysica acta. Molecular and cell biology of lipids 9 30862571
2023 ASL mRNA-LNP Therapeutic for the Treatment of Argininosuccinic Aciduria Enables Survival Benefit in a Mouse Model. Biomedicines 8 37371829
2015 Oxidative injury induced by cadmium sulfide nanoparticles in A549 cells and rat lungs. Inhalation toxicology 8 26405836
2007 Characterization and physical mapping of the porcine CDS1 and CDS2 genes. Animal biotechnology 8 17364441
2022 Comparative chloroplast genomes and phylogenetic relationships of Aglaonema modestum and five variegated cultivars of Aglaonema. PloS one 7 36054201
2022 Cytidinediphosphate diacylglycerol synthase-Mediated phosphatidic acid metabolism is crucial for early embryonic development of Arabidopsis. PLoS genetics 6 35877676
2020 Mutation screening of the UBE3A gene in Chinese Han population with autism. BMC psychiatry 6 33308194
2025 Cytidine diphosphate diacylglycerol synthase 2 is a synthetic lethal target in mesenchymal-like cancers. Nature genetics 4 40615674
2024 CDS2 expression regulates de novo phosphatidic acid synthesis. The Biochemical journal 4 39312194
2021 A novel RNA pol II CTD interaction site on the mRNA capping enzyme is essential for its allosteric activation. Nucleic acids research 4 33684220
2023 The identification of metabolism-related subtypes and potential treatments for idiopathic pulmonary fibrosis. Frontiers in pharmacology 3 37274115
2022 Chicken CDS2 isoforms presented distinct spatio-temporal expression pattern and regulated by insulin in a breed-specific manner. Poultry science 3 35504066
2025 Integrative genomic identification of therapeutic targets for pancreatic cancer. Cell reports 2 40848256
2020 Ecotopic over-expression of PoCHS from Paeonia ostii altered the fatty acids composition and content in Arabidopsis thaliana. Physiologia plantarum 2 33247451
2025 Integrated Transcriptomic and Metabolomic Analysis of the Mechanism of Intramuscular Fat Differences in Wandong Cattle. International journal of molecular sciences 1 41373709
2024 Network Pharmacology Approaches Used to Identify Therapeutic Molecules for Chronic Venous Disease Based on Potential miRNA Biomarkers. Journal of xenobiotics 1 39449424
2026 Hydroxyl radical-mediated oxidative modification of Camellia sinensis (L.) Kuntze cell-wall polysaccharides alleviates obesity by modulating glucose and lipid metabolism. Glycobiology 0 41841787
2026 Integrated metabolomic and transcriptomic analysis reveals novel plasma biomarkers and metabolic pathway dysregulation in latent tuberculosis infection. Microbiology spectrum 0 41891697
2026 Functional Prediction of AT5G35460 Reveals Its Regulatory Role in Reproductive Development and Lipid Remodeling in Arabidopsis thaliana. Membranes 0 41893274
2025 RXLR effectors from Phytophthora infestans suppress host cell death and promote virulence via nuclear localization in Nicotiana benthamiana. Plant science : an international journal of experimental plant biology 0 40854374
2025 Carbon dot (CD)-based fluorescent probes for rapid and real-time tracking lysosomes movement and ATP monitoring in live cell. Mikrochimica acta 0 40936032
2025 Mechanism of Quercetin alleviated E. coli K88-induced Liver Injury in Broilers. Poultry science 0 40976095
2025 Chlorogenic Acid and VX765 Alleviate Deoxynivalenol-Induced Enterohepatic Injury and Lipid Metabolism Disorders by Improving Intestinal Microecology. Toxins 0 41003531
2024 Quantifying Personalized Shift-Work Molecular Portraits Underlying Alzheimer's Disease through Computational Biology. The journal of prevention of Alzheimer's disease 0 39559883
2003 Evidence for a type III secretion system in Chlamydophila psittaci. Communications in agricultural and applied biological sciences 0 24757810