Affinage

CDS2

Phosphatidate cytidylyltransferase 2 · UniProt O95674

Length
445 aa
Mass
51.4 kDa
Annotated
2026-06-09
66 papers in source corpus 19 papers cited in narrative 19 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

CDS2 is an ER-resident integral membrane CDP-diacylglycerol synthase that converts phosphatidic acid (PA) to CDP-diacylglycerol, supplying the activated lipid intermediate for de novo phosphatidylinositol synthesis (PMID:9407135, PMID:29253589, PMID:32117988). Among the two mammalian CDS isoforms, CDS2 is the principal enzyme sustaining PI resynthesis during PLC-driven phosphoinositide recycling, where it preferentially channels arachidonoyl-enriched PA species toward PI and is required to maintain enhanced PI synthesis through the PI cycle under sustained receptor stimulation; its loss instead drives accumulation of PA, CDP-DG, DG, and TG (PMID:35712788, PMID:39312194). By controlling ER and lipid-droplet PA levels, CDS2 restrains lipid droplet growth through a mechanism distinct from CDS1, with its deficiency promoting LD association of DGAT2 and GPAT4 and producing giant lipid droplets (PMID:26946540, PMID:31548309). In endothelium, CDS2-dependent maintenance of PIP2/PIP3 governs VEGFA signaling output, such that CDS2 ablation reduces PIP3, activates FOXO1, and switches angiogenesis to vessel regression (PMID:31501519). CDS2 is enriched at mitochondria-associated membranes and supports mitochondrial PE levels and function, with liver-specific loss provoking a NASH-like phenotype that is rescued by PISD overexpression (PMID:36546079). CDS2 and CDS1 form a functionally redundant synthetic lethal pair: in tumors with low CDS1 expression, CDS2 loss disrupts phosphoinositide synthesis and triggers apoptosis in a manner dependent on CDS2 catalytic activity, defining CDS2 as a tractable cancer dependency (PMID:40615675, PMID:40615674).

Mechanistic history

Synthesis pass · year-by-year structured walk · 9 steps
  1. 1998 Medium

    Establishing that mammals encode two distinct CDP-diacylglycerol synthases set the stage for dissecting isoform-specific roles in phospholipid synthesis.

    Evidence cDNA cloning of CDS1 and CDS2 with radiation hybrid and FISH chromosomal mapping; identification as homolog of Drosophila CDS

    PMID:9407135 PMID:9806839 PMID:9889000

    Open questions at the time
    • Catalytic mechanism and substrate specificity not resolved at cloning
    • Functional difference between CDS1 and CDS2 not yet addressed
  2. 2005 Medium

    Localizing both isoforms answered where CDS2 acts, placing the enzyme at the ER and distinguishing its ubiquitous expression from the restricted distribution of CDS1.

    Evidence Transient transfection of epitope-tagged murine Cds1/Cds2 with immunofluorescence and in situ hybridization

    PMID:16023307

    Open questions at the time
    • Based on tagged overexpression rather than endogenous protein
    • Submembrane/contact-site localization not addressed
  3. 2017 High

    Resolving an earlier mitochondrial attribution clarified that CDS2 is an ER integral membrane enzyme and that mitochondrial CDP-DAG synthesis is provided by TAMM41, sharpening the compartmental model.

    Evidence Subcellular fractionation, TAMM41 knockdown, and enzyme activity assays

    PMID:29253589

    Open questions at the time
    • Does not exclude MAM-localized CDS2 contributions to mitochondrial lipids
    • Reconciliation with CDS2-dependent cardiolipin phenotypes not addressed
  4. 2019 High

    Connecting CDS2 to phosphoinositide pools demonstrated its physiological role in PI cycle recycling and in tuning VEGFA-driven endothelial behavior, moving the enzyme from a biosynthetic step to a signaling controller.

    Evidence Zebrafish and mouse knockouts with live imaging and PIP2/PIP3 quantification; isotope tracing with LC-MS showing arachidonoyl-PA routing to PI

    PMID:31501519 PMID:35712788

    Open questions at the time
    • Mechanism of arachidonoyl-PA species selection not defined
    • How CDS2 is recruited to PLC-active sites unknown
  5. 2019 High

    Defining the lipid droplet phenotype showed CDS2 restrains LD growth through a CDS1-distinct, DGAT2/GPAT4-dependent route driven by PA accumulation, separating the two isoforms mechanistically.

    Evidence siRNA and CRISPR knockout with epistasis rescues (DGAT2/GPAT4 vs CIDEC), lipidomics, and fluorescence microscopy

    PMID:26946540 PMID:31548309

    Open questions at the time
    • Direct biochemical link between surface PA and DGAT2/GPAT4 recruitment not established
    • Whether enzymatic activity per se or PA level drives LD effect not fully separated
  6. 2021 High

    Liver-specific loss tied CDS2 to mitochondria-associated membranes and mitochondrial PE homeostasis, explaining how its deficiency produces metabolic disease.

    Evidence Hepatocyte conditional knockout with mitochondrial fractionation, lipidomics, PISD-overexpression and PPARα-agonist rescue

    PMID:36546079

    Open questions at the time
    • Molecular basis of CDS2 enrichment at MAMs unknown
    • How ER CDP-DAG output feeds mitochondrial PE not mechanistically traced
  7. 2024 High

    Quantitative tracing in macrophages distinguished CDS2's modest role in basal PI synthesis from its essential role in sustaining PI-cycle flux, refining where the enzyme is rate-limiting.

    Evidence CRISPR deletion with dual stable-isotope labeling, LC-MS lipidomics, GPCR-stimulated PLC assays, and calcium imaging

    PMID:39312194

    Open questions at the time
    • Origin of the PLC-independent calcium homeostasis defect unexplained
    • Whether CDS1 compensates basal synthesis not directly tested here
  8. 2025 High

    Genome-scale screens established CDS1/CDS2 as a robust synthetic lethal pair, demonstrating that CDS2 catalytic activity becomes essential in low-CDS1 tumors and nominating it as a cancer target.

    Evidence Single-gene and paired CRISPR screens, catalytic-mutant and CDS1 re-expression rescues, lipidomics, apoptosis assays, and in vivo xenografts

    PMID:40615674 PMID:40615675

    Open questions at the time
    • Structural basis for catalysis and potential inhibitor binding not defined
    • Determinants of CDS1 silencing across tumor types not addressed
  9. 2025 Medium

    A proposed CDS2-MBOAT7 ER interaction introduces a candidate adaptive response coupling CDS2 loss to lipid droplet regulation, but this awaits peer-reviewed confirmation.

    Evidence Co-immunoprecipitation, confocal imaging, RAB1 manipulation, and LD assays (preprint)

    PMID:bio_10.1101_2025.08.26.672501

    Open questions at the time
    • Preprint, not yet peer-reviewed
    • Reciprocal/structural validation of CDS2-MBOAT7 binding not shown
    • Physiological significance of MBOAT7 relocalization unestablished

Open questions

Synthesis pass · forward-looking unresolved questions
  • How CDS2 is recruited and regulated at distinct membrane subdomains (PLC-active sites, lipid droplet contacts, MAMs) to channel specific PA species into different downstream lipids remains unresolved.
  • No structural model of substrate selection or activity regulation
  • Mechanism of spatial targeting to subcompartments unknown
  • Direct regulators of CDS2 activity (vs transcriptional control) uncharacterized

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0016740 transferase activity 4 GO:0016787 hydrolase activity 2
Localization
GO:0005783 endoplasmic reticulum 4 GO:0005739 mitochondrion 1
Pathway
R-HSA-1430728 Metabolism 4 R-HSA-5357801 Programmed Cell Death 3 R-HSA-162582 Signal Transduction 2
Partners
CDS1DGAT2GPAT4MBOAT7

Evidence

Reading pass · 19 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1997 CDS2 (CDP-diacylglycerol synthetase 2) was identified as a second human CDS enzyme in the EST database. Overexpression of CDS1 or PIS1 alone or in combination did not enhance the rate of phosphatidylinositol biosynthesis, indicating that the levels of CDS1 and PIS1 protein expression are not critical determinants of cellular PI content. cDNA cloning from EST database, COS-7 cell overexpression, phospholipid metabolic assays The Journal of biological chemistry Medium 9407135
1998 Two human CDP-diacylglycerol synthase genes, CDS1 and CDS2, were cloned and localized to chromosomes 4q21 and 20p13, respectively, by radiation hybrid panel mapping and FISH. cDNA cloning, radiation hybrid panel mapping, fluorescence in situ hybridization Genomics Medium 9806839
1999 Human CDS2 was identified as a mammalian homolog of Drosophila CDS, encoding CDP-diacylglycerol synthase. Mouse Cds2 (but not Cds1) showed high expression in differentiating neuroblasts of the neural retina and CNS during embryonic development, with no detection in adult retina, while Cds1 was highly expressed in the photoreceptor layer of adult retina. Bioinformatic identification, cDNA isolation and sequencing, RNA in situ hybridization on mouse tissue sections Genomics Medium 9889000
2003 CDS-2 activity and mRNA level in mouse heart were elevated by PPARα activation (clofibrate feeding) in vivo; in PPARα-null mice, clofibrate feeding did not alter CDS-2 activity or mRNA level, confirming CDS-2 is regulated by PPARα activation. CDS-2 activity was not affected by clofibrate in H9c2 cells in vitro, indicating alternative regulation in vivo versus cultured cells. In vivo clofibrate treatment, PPARα-null mouse model, enzyme activity assays, mRNA quantification Journal of lipid research Medium 14594999
2005 Murine Cds1 and Cds2 proteins, when transiently transfected with epitope tags, were both associated with the endoplasmic reticulum. Cds2 shows ubiquitous expression while Cds1 shows restricted expression including in photoreceptor inner segments. Transient transfection of epitope-tagged proteins, subcellular localization by immunofluorescence, RNA in situ hybridization Gene Medium 16023307
2010 Knockdown of CDS-2 (via shRNA) disrupted cardiolipin biosynthesis and eliminated mitomycin C-induced translocation of p53 to mitochondria, as well as reducing mitochondrial distribution of Bcl-xL and Bcl-2, placing CDS2-dependent cardiolipin synthesis upstream of mitochondrial p53 localization and apoptosis regulation. shRNA knockdown of CDS-2, immunofluorescence for mitochondrial p53 localization, Western blot for Bcl-xL/Bcl-2 Neoplasia (New York, N.Y.) Medium 20126473
2016 Knockdown of CDS2 (or CDS1) resulted in formation of giant/supersized lipid droplets in cultured mammalian cells and dramatically increased PA levels in the endoplasmic reticulum. Depleting CDS2 had a moderate inhibitory effect on 3T3-L1 preadipocyte differentiation. The increase in ER PA levels upon CDS2 knockdown suggests PA accumulation underlies the lipid droplet phenotype. siRNA knockdown, lipid droplet imaging, phospholipid mass spectrometry, adipocyte differentiation assay Journal of lipid research High 26946540
2017 Mitochondrial CDP-diacylglycerol synthase activity was found to be due to TAMM41 (a peripheral mitochondrial protein), not CDS1 or CDS2 (integral membrane proteins). CDS1 and CDS2 are localized to the endoplasmic reticulum, not mitochondria. Subcellular fractionation, Western blot, TAMM41 knockdown, enzyme activity assays, H9c2 differentiation Biochimica et biophysica acta. Molecular and cell biology of lipids High 29253589
2018 p53 physically interacts with SIRT6 in vitro and in vivo, and together they bind the promoters of CDS1 and CDS2 to enhance cardiolipin de novo biosynthesis; SIRT6 acts as a co-activator of p53, recruiting RNA polymerase II to CDS1 and CDS2 promoters in response to palmitic acid treatment. Co-immunoprecipitation, chromatin immunoprecipitation (ChIP), in vitro binding assay, cardiolipin biosynthesis assay Cell death & disease Medium 30237540
2019 Genetic ablation of CDS2 in zebrafish and mice switched VEGFA signaling output from promoting angiogenesis to inducing vessel regression. Mechanistically, VEGFA stimulation in CDS2-null endothelium reduced PIP2 availability, causing PIP3 deficiency and FOXO1 activation, which triggered endothelial regression. Re-expression experiments and live imaging confirmed this mechanism. Zebrafish cds2 mutant, mouse conditional knockout, live imaging, PIP2/PIP3 quantification, FOXO1 localization, tumor implantation models Cell research High 31501519
2019 CDS2, but not CDS1, contributes to increased PI resynthesis during PLC activation and preferentially routes arachidonoyl-enriched PA species toward PI synthesis, contributing to maintenance of the unique fatty acid profile of phosphoinositide lipids. siRNA knockdown, stable isotope labeling with 13C-glucose, LC-MS lipid analysis EMBO reports Medium 35712788
2019 CDS2-deficient lipid droplet phenotype is rescued by reducing DGAT2 or GPAT4 expression (but not by reducing CIDEC), while CDS1-deficient LD phenotype is rescued by CIDEC knockdown (but not DGAT2/GPAT4), demonstrating that CDS1 and CDS2 regulate lipid droplet growth through distinct mechanisms. CDS2 deficiency promoted LD association of DGAT2 and GPAT4 and impaired initial LD maturation. CDS2 had a stronger effect on PA levels at the LD surface. siRNA knockdown, CRISPR/Cas9 knockout, immunofluorescence, fluorescence microscopy, lipidomics The Journal of biological chemistry High 31548309
2019 Vasopressin selectively stimulates an increase in CDS1 (not CDS2) mRNA in H9c2 cardiomyoblasts, mediated through phospholipase C, protein kinase C, and cFos (AP-1); this mechanism provides upregulation of PI resynthesis specifically through CDS1 during sustained PLC signaling. RT-qPCR, AP-1 inhibitor (T-5224), PKC inhibitor, Western blot for cFos Biochimica et biophysica acta. Molecular and cell biology of lipids Medium 30862571
2020 CDS enzymes CDS1 and CDS2 are ancient integral membrane proteins localized to the ER in mammals, providing CDP-DAG for PI synthesis; CDS2 is suggested to be the major CDS for phosphoinositide recycling during PLC signaling based on reviewed experimental evidence. Review synthesizing localization and functional data from multiple experimental studies Frontiers in cell and developmental biology Medium 32117988
2021 Liver-specific Cds2 deficiency in mice provoked hepatic steatosis, inflammation and fibrosis. CDS2 is enriched in mitochondria-associated membranes (MAMs). Hepatic Cds2 deficiency impaired mitochondrial function and decreased mitochondrial PE levels. Overexpression of phosphatidylserine decarboxylase (PISD) alleviated the NASH-like phenotype and mitochondrial dysfunction caused by CDS2 deficiency. PPARα agonist treatment also attenuated mitochondrial defects. Cds2 overexpression protected against high-fat diet-induced hepatic steatosis. Liver-specific conditional knockout (Cds2f/f;AlbCre), mitochondrial fractionation, lipidomics, PISD overexpression rescue, electron microscopy, PPARα agonist treatment, Cds2 overexpression Science bulletin High 36546079
2024 Genetic deletion of CDS2 in primary mouse macrophages resulted in modest changes in steady-state PI levels but substantial increases in PA, CDP-DG, DG, and TG. Stable isotope labeling showed CDS2 loss caused minimal reduction in basal de novo PI synthesis rate but substantially increased de novo PA synthesis from glycerol-3-phosphate (G3P). Under sustained GPCR-stimulated PLC conditions, CDS2-deficient macrophages could not maintain enhanced PI synthesis via the 'PI cycle', leading to substantial PI loss. CDS2-deficient macrophages exhibited defects in calcium homeostasis unrelated to PLC activation. CRISPR/Cas9 deletion, stable isotope labeling (13C6- and 13C6D7-glucose), LC-MS lipidomics, GPCR stimulation assays, calcium imaging The Biochemical journal High 39312194
2025 CDS2 is a synthetic lethal dependency in uveal melanoma and other tumor types with low CDS1 expression. CDS2 knockout in low-CDS1 cancer cells disrupted phosphoinositide synthesis, increased cellular apoptosis, and re-expression of CDS1 rescued this cell fitness defect, establishing CDS1/CDS2 as a functionally redundant synthetic lethal pair. The synthetic lethality was validated in vivo. CRISPR-Cas9 screening (single-gene and combinatorial paired-gene libraries), CDS1 re-expression rescue, in vivo xenograft models, pan-cancer data analysis Nature genetics High 40615675
2025 CDS2 essentiality in mesenchymal-like cancers with low/absent CDS1 expression is mechanistically driven by CDS2 dosage and catalytic activity (not a scaffolding role). CDS1-CDS2 synthetic lethality is accompanied by disruption of lipid homeostasis including accumulation of cholesterol esters and triglycerides, and apoptosis. Genome-wide CRISPR knockout screens identified no common escape mechanism, indicating robustness of the interaction. Computational SLI analysis, CRISPR-Cas9 knockout screens, catalytic mutant rescue experiments, lipidomics, apoptosis assays Nature genetics High 40615674
2025 Under physiological conditions, MBOAT7 interacts with CDS2 at the endoplasmic reticulum to maintain lipid metabolic homeostasis. Disruption of this interaction (via CDS2 knockdown or loss of function) triggers adaptive translocation of MBOAT7 to ER-lipid droplet contact sites in a RAB1-dependent manner, where it inhibits DGAT2-mediated lipid droplet growth and promotes lipolysis. Co-immunoprecipitation, confocal microscopy, siRNA knockdown, RAB1 manipulation, lipid droplet assays bioRxivpreprint Medium bio_10.1101_2025.08.26.672501

Source papers

Stage 0 corpus · 66 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2001 Performance of comorbidity scores to control for confounding in epidemiologic studies using claims data. American journal of epidemiology 624 11682368
2013 MMAPPR: mutation mapping analysis pipeline for pooled RNA-seq. Genome research 285 23299975
2009 Abscisic acid has a key role in modulating diverse plant-pathogen interactions. Plant physiology 236 19571312
2006 Identification of MglA-regulated genes reveals novel virulence factors in Francisella tularensis. Infection and immunity 139 17000729
2012 High levels of RNA-editing site conservation amongst 15 laboratory mouse strains. Genome biology 135 22524474
2000 Evidence for the secretion of Chlamydia trachomatis CopN by a type III secretion mechanism. Molecular microbiology 132 11123678
2019 Phosphatidylinositol synthesis at the endoplasmic reticulum. Biochimica et biophysica acta. Molecular and cell biology of lipids 103 31173893
1997 The role of CDP-diacylglycerol synthetase and phosphatidylinositol synthase activity levels in the regulation of cellular phosphatidylinositol content. The Journal of biological chemistry 102 9407135
2008 Cardiolipin biosynthesis and remodeling enzymes are altered during development of heart failure. Journal of lipid research 91 19001357
2020 CDP-Diacylglycerol Synthases (CDS): Gateway to Phosphatidylinositol and Cardiolipin Synthesis. Frontiers in cell and developmental biology 86 32117988
2011 Underexpression of miR-224 in methotrexate resistant human colon cancer cells. Biochemical pharmacology 69 21864507
2013 The identification of novel targets of miR-16 and characterization of their biological functions in cancer cells. Molecular cancer 52 23941513
2019 Endothelial CDS2 deficiency causes VEGFA-mediated vascular regression and tumor inhibition. Cell research 49 31501519
2020 Establishment and characterization of NCC-CDS2-C1: a novel patient-derived cell line of CIC-DUX4 sarcoma. Human cell 46 31898195
2020 RNA-Seq based genetic variant discovery provides new insights into controlling fat deposition in the tail of sheep. Scientific reports 46 32782325
2016 CDP-diacylglycerol synthases regulate the growth of lipid droplets and adipocyte development. Journal of lipid research 43 26946540
2005 Isolation and characterization of murine Cds (CDP-diacylglycerol synthase) 1 and 2. Gene 40 16023307
2017 Mitochondrial CDP-diacylglycerol synthase activity is due to the peripheral protein, TAMM41 and not due to the integral membrane protein, CDP-diacylglycerol synthase 1. Biochimica et biophysica acta. Molecular and cell biology of lipids 39 29253589
2008 STAT-3 regulates surfactant phospholipid homeostasis in normal lung and during endotoxin-mediated lung injury. Journal of applied physiology (Bethesda, Md. : 1985) 38 18369093
2021 Hepatic CDP-diacylglycerol synthase 2 deficiency causes mitochondrial dysfunction and promotes rapid progression of NASH and fibrosis. Science bulletin 37 36546079
2006 Interleukin-17 receptor-like gene is a novel antiapoptotic gene highly expressed in androgen-independent prostate cancer. Cancer research 37 16397230
2021 Phospholipid dynamics in ex vivo lung cancer and normal lung explants. Experimental & molecular medicine 36 33408336
2002 Differential expression of cold- and diet-specific genes encoding two carp liver delta 9-acyl-CoA desaturase isoforms. American journal of physiology. Regulatory, integrative and comparative physiology 36 12388470
1999 Identification and characterization of CDS2, a mammalian homolog of the Drosophila CDP-diacylglycerol synthase gene. Genomics 35 9889000
1998 Isolation and chromosomal localization of two human CDP-diacylglycerol synthase (CDS) genes. Genomics 35 9806839
2019 CDP-DAG synthase 1 and 2 regulate lipid droplet growth through distinct mechanisms. The Journal of biological chemistry 33 31548309
2018 p53 cooperates with SIRT6 to regulate cardiolipin de novo biosynthesis. Cell death & disease 32 30237540
2021 Genome-wide analyses reveal population structure and identify candidate genes associated with tail fatness in local sheep from a semi-arid area. Animal : an international journal of animal bioscience 29 33715983
2019 Dysregulation of MicroRNA Regulatory Network in Lower Extremities Arterial Disease. Frontiers in genetics 29 31827490
2014 Genome-wide transcriptomic profiling of ramie (Boehmeria nivea L. Gaud) in response to cadmium stress. Gene 29 25550046
2003 Stimulation of cardiac cardiolipin biosynthesis by PPARalpha activation. Journal of lipid research 28 14594999
2020 Integrated Analysis of lncRNA-miRNA-mRNA ceRNA Network Identified lncRNA EPB41L4A-AS1 as a Potential Biomarker in Non-small Cell Lung Cancer. Frontiers in genetics 27 33193600
2021 Comparison of the effects of synthesis methods of B, N, S, and P-doped carbon dots with high photoluminescence properties on HeLa tumor cells. RSC advances 25 35423683
2022 Metabolic routing maintains the unique fatty acid composition of phosphoinositides. EMBO reports 24 35712788
2021 Exosomal Circular RNA RNA-seq Profiling and the Carcinogenic Role of Exosomal circ-CYP24A1 in Cutaneous Squamous Cell Carcinoma. Frontiers in medicine 20 34109199
2008 Prolonged androgen receptor loading onto chromatin and the efficient recruitment of p160 coactivators contribute to androgen-independent growth of prostate cancer cells. The Prostate 20 18780293
2021 Identification of Novel Gene Signatures using Next-Generation Sequencing Data from COVID-19 Infection Models: Focus on Neuro-COVID and Potential Therapeutics. Frontiers in pharmacology 18 34531741
2010 Translocation of p53 to mitochondria is regulated by its lipid binding property to anionic phospholipids and it participates in cell death control. Neoplasia (New York, N.Y.) 17 20126473
2020 Transcriptome analysis on responses of orchardgrass (Dactylis glomerata L.) leaves to a short term flooding. Hereditas 16 32418541
2010 Rapid decrease in active tension generated by C2C12 myotubes after termination of artificial exercise. Journal of muscle research and cell motility 14 21120590
2019 Prioritization of metabolic genes as novel therapeutic targets in estrogen-receptor negative breast tumors using multi-omics data and text mining. Oncotarget 12 31231467
2025 The synthetic lethal interaction between CDS1 and CDS2 is a vulnerability in uveal melanoma and across multiple tumor types. Nature genetics 11 40615675
2020 The Nature and Extent of Plasmid Variation in Chlamydia trachomatis. Microorganisms 11 32155798
2009 Regulation of cardiolipin biosynthesis by fatty acid transport protein-1 IN HEK 293 cells. Biochimica et biophysica acta 10 19523918
2009 The effects of pyridoxine deficiency and supplementation on hematological profiles, lymphocyte function, and hepatic cytochrome P450 in B6C3F1 mice. Journal of immunotoxicology 10 19637937
2019 Sustained phospholipase C stimulation of H9c2 cardiomyoblasts by vasopressin induces an increase in CDP-diacylglycerol synthase 1 (CDS1) through protein kinase C and cFos. Biochimica et biophysica acta. Molecular and cell biology of lipids 9 30862571
2015 Oxidative injury induced by cadmium sulfide nanoparticles in A549 cells and rat lungs. Inhalation toxicology 9 26405836
2023 ASL mRNA-LNP Therapeutic for the Treatment of Argininosuccinic Aciduria Enables Survival Benefit in a Mouse Model. Biomedicines 8 37371829
2007 Characterization and physical mapping of the porcine CDS1 and CDS2 genes. Animal biotechnology 8 17364441
2020 Mutation screening of the UBE3A gene in Chinese Han population with autism. BMC psychiatry 6 33308194
2025 Cytidine diphosphate diacylglycerol synthase 2 is a synthetic lethal target in mesenchymal-like cancers. Nature genetics 5 40615674
2025 Integrative genomic identification of therapeutic targets for pancreatic cancer. Cell reports 5 40848256
2024 CDS2 expression regulates de novo phosphatidic acid synthesis. The Biochemical journal 5 39312194
2021 A novel RNA pol II CTD interaction site on the mRNA capping enzyme is essential for its allosteric activation. Nucleic acids research 4 33684220
2023 The identification of metabolism-related subtypes and potential treatments for idiopathic pulmonary fibrosis. Frontiers in pharmacology 3 37274115
2022 Chicken CDS2 isoforms presented distinct spatio-temporal expression pattern and regulated by insulin in a breed-specific manner. Poultry science 3 35504066
2025 Integrated Transcriptomic and Metabolomic Analysis of the Mechanism of Intramuscular Fat Differences in Wandong Cattle. International journal of molecular sciences 2 41373709
2025 Chlorogenic Acid and VX765 Alleviate Deoxynivalenol-Induced Enterohepatic Injury and Lipid Metabolism Disorders by Improving Intestinal Microecology. Toxins 1 41003531
2024 Network Pharmacology Approaches Used to Identify Therapeutic Molecules for Chronic Venous Disease Based on Potential miRNA Biomarkers. Journal of xenobiotics 1 39449424
2026 Hydroxyl radical-mediated oxidative modification of Camellia sinensis (L.) Kuntze cell-wall polysaccharides alleviates obesity by modulating glucose and lipid metabolism. Glycobiology 0 41841787
2026 Integrated metabolomic and transcriptomic analysis reveals novel plasma biomarkers and metabolic pathway dysregulation in latent tuberculosis infection. Microbiology spectrum 0 41891697
2025 RXLR effectors from Phytophthora infestans suppress host cell death and promote virulence via nuclear localization in Nicotiana benthamiana. Plant science : an international journal of experimental plant biology 0 40854374
2025 Carbon dot (CD)-based fluorescent probes for rapid and real-time tracking lysosomes movement and ATP monitoring in live cell. Mikrochimica acta 0 40936032
2025 Mechanism of Quercetin alleviated E. coli K88-induced Liver Injury in Broilers. Poultry science 0 40976095
2024 Quantifying Personalized Shift-Work Molecular Portraits Underlying Alzheimer's Disease through Computational Biology. The journal of prevention of Alzheimer's disease 0 39559883
2003 Evidence for a type III secretion system in Chlamydophila psittaci. Communications in agricultural and applied biological sciences 0 24757810

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