Affinage

RPS7

Small ribosomal subunit protein eS7 · UniProt P62081

Audit flag: rerun needed
Length
194 aa
Mass
22.1 kDa
Annotated
2026-04-28
130 papers in source corpus

Mechanistic narrative

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Mechanism profile

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Source papers

Stage 0 corpus · 130 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2012 Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 1718 22658674
2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America 1479 12477932
2015 The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell 1118 26186194
2017 Architecture of the human interactome defines protein communities and disease networks. Nature 1085 28514442
2015 A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell 1015 26496610
2014 A proteome-scale map of the human interactome network. Cell 977 25416956
2012 The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Molecular cell 973 22681889
2018 VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell discovery 829 29507755
2003 Complete sequencing and characterization of 21,243 full-length human cDNAs. Nature genetics 754 14702039
2021 Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Cell 705 33961781
2012 A census of human soluble protein complexes. Cell 689 22939629
2011 Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Briefings in bioinformatics 656 21873635
2005 Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin. Cell 544 16213212
2017 Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15. Science (New York, N.Y.) 533 28302793
2011 Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Nature cell biology 490 21423176
2013 Structures of the human and Drosophila 80S ribosome. Nature 481 23636399
2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome research 438 15489334
2022 OpenCell: Endogenous tagging for the cartography of human cellular organization. Science (New York, N.Y.) 432 35271311
1998 Importin beta, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells. The EMBO journal 431 9687515
2010 Global analysis of TDP-43 interacting proteins reveals strong association with RNA splicing and translation machinery. Journal of proteome research 422 20020773
2015 Panorama of ancient metazoan macromolecular complexes. Nature 407 26344197
2004 The molecular mechanics of eukaryotic translation. Annual review of biochemistry 396 15189156
2015 Structure of the human 80S ribosome. Nature 380 25901680
2015 Proteome-wide profiling of protein assemblies by cross-linking mass spectrometry. Nature methods 370 26414014
2007 Functional specialization of beta-arrestin interactions revealed by proteomic analysis. Proceedings of the National Academy of Sciences of the United States of America 360 17620599
2008 Ribosomal protein L5 and L11 mutations are associated with cleft palate and abnormal thumbs in Diamond-Blackfan anemia patients. American journal of human genetics 340 19061985
2014 A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways. Cell 325 25036637
2010 Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. Cell 318 21145461
2012 A high-throughput approach for measuring temporal changes in the interactome. Nature methods 273 22863883
1995 Structure and evolution of mammalian ribosomal proteins. Biochemistry and cell biology = Biochimie et biologie cellulaire 265 8722009
2007 Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function. Oncogene 220 17310983
2009 Ribosomal protein S7 is both a regulator and a substrate of MDM2. Molecular cell 180 19683495
1994 CD43 (S7) expression identifies peripheral B cell subsets. Journal of immunology (Baltimore, Md. : 1950) 112 7989752
1988 Assembly of the 30S subunit from Escherichia coli ribosomes occurs via two assembly domains which are initiated by S4 and S7. Biochemistry 108 2461734
1998 Detection and assignment of proteins encoded by rice black streaked dwarf fijivirus S7, S8, S9 and S10. The Journal of general virology 102 9634092
1975 Specific cross-linking of proteins S7 and L4 to ribosomal RNA, by UV irradiation of Escherichia coli ribosomal subunits. Molecular & general genetics : MGG 102 814400
1983 The localization of multiple sites on 16S RNA which are cross-linked to proteins S7 and S8 in Escherichia coli 30S ribosomal subunits by treatment with 2-iminothiolane. Nucleic acids research 74 6338481
1976 The isolation of eukaryotic ribosomal proteins. The purification and characterization of the 40 S ribosomal subunit proteins S2, S3, S4, S5, S6, S7, S8, S9, S13, S23/S24, S27, and S28. The Journal of biological chemistry 72 947902
1988 Probing the assembly of the 3' major domain of 16 S ribosomal RNA. Quaternary interactions involving ribosomal proteins S7, S9 and S19. Journal of molecular biology 67 3373531
2005 Structural locations and functional roles of new subsites S5, S6, and S7 in memapsin 2 (beta-secretase). Biochemistry 66 15628850
2015 Mutation in mitochondrial ribosomal protein S7 (MRPS7) causes congenital sensorineural deafness, progressive hepatic and renal failure and lactic acidemia. Human molecular genetics 65 25556185
1975 Nucleotide sequences of Escherichia coli 16-S RNA associated with ribosomal proteins S7, S9, S10, S14 and S19. European journal of biochemistry 64 1100389
1997 The structure of ribosomal protein S7 at 1.9 A resolution reveals a beta-hairpin motif that binds double-stranded nucleic acids. Structure (London, England : 1993) 62 9331418
1984 The genes for the ribosomal proteins S12 and S7 are clustered with the gene for the EF-Tu protein on the chloroplast genome of Euglena gracilis. Nucleic acids research 62 6324129
2013 Small ribosomal protein subunit S7 suppresses ovarian tumorigenesis through regulation of the PI3K/AKT and MAPK pathways. PloS one 61 24244431
2011 Ling Zhi-8 mediates p53-dependent growth arrest of lung cancer cells proliferation via the ribosomal protein S7-MDM2-p53 pathway. Carcinogenesis 61 21983128
1975 Neutron scattering measurements of separation and shape of proteins in 30S ribosomal subunit of Escherichia coli: S2-S5, S5-S8, S3-S7. Proceedings of the National Academy of Sciences of the United States of America 59 1105567
1997 Ribosomal protein S7: a new RNA-binding motif with structural similarities to a DNA architectural factor. Structure (London, England : 1993) 57 9331423
1987 RNA-protein cross-linking in Escherichia coli 30S ribosomal subunits; determination of sites on 16S RNA that are cross-linked to proteins S3, S4, S7, S9, S10, S11, S17, S18 and S21 by treatment with bis-(2-chloroethyl)-methylamine. Nucleic acids research 54 2437528
2000 Mapping subunit contacts in the regulatory complex of the 26 S proteasome. S2 and S5b form a tetramer with ATPase subunits S4 and S7. The Journal of biological chemistry 53 10625621
1987 RNA-protein cross-linking in Escherichia coli 30S ribosomal subunits; determination of sites on 16S RNA that are cross-linked to proteins S3, S4, S5, S7, S8, S9, S11, S13, S19 and S21 by treatment with methyl p-azidophenyl acetimidate. Nucleic acids research 53 2437527
1976 Studies on the environment of protein S7 within the 30-S subunit Escherichia coli ribosomes. European journal of biochemistry 53 776616
2007 Molecular phylogenetics of the family Cyprinidae (Actinopterygii: Cypriniformes) as evidenced by sequence variation in the first intron of S7 ribosomal protein-coding gene: further evidence from a nuclear gene of the systematic chaos in the family. Molecular phylogenetics and evolution 52 18203625
1996 Primary structure of ribosomal proteins S3 and S7 from Manduca sexta. Insect molecular biology 52 8630533
2000 Phylogenetic relationships of bluetongue viruses based on gene S7. Virus research 49 10867193
1981 Identification of ribosomal protein S7 as a repressor of translation within the str operon of E. coli. Cell 46 7016341
1994 Post-transcriptional regulation of the str operon in Escherichia coli. Ribosomal protein S7 inhibits coupled translation of S7 but not its independent translation. Journal of molecular biology 45 7507167
2013 Mutation of the diamond-blackfan anemia gene Rps7 in mouse results in morphological and neuroanatomical phenotypes. PLoS genetics 43 23382688
1990 Genes for the plastid elongation factor Tu and ribosomal protein S7 and six tRNA genes on the 73 kb DNA from Astasia longa that resembles the chloroplast DNA of Euglena. Molecular & general genetics : MGG 43 2338940
1989 Genes for the ribosomal proteins S12 and S7 and elongation factors EF-G and EF-Tu of the cyanobacterium, Anacystis nidulans: structural homology between 16S rRNA and S7 mRNA. Molecular & general genetics : MGG 43 2499762
2021 SMYD2 promotes tumorigenesis and metastasis of lung adenocarcinoma through RPS7. Cell death & disease 40 33935284
2017 A Novel Quorum-Quenching N-Acylhomoserine Lactone Acylase from Acidovorax sp. Strain MR-S7 Mediates Antibiotic Resistance. Applied and environmental microbiology 40 28455333
2016 RPS7 inhibits colorectal cancer growth via decreasing HIF-1α-mediated glycolysis. Oncotarget 40 26735579
2011 Knockdown of ribosomal protein S7 causes developmental abnormalities via p53 dependent and independent pathways in zebrafish. The international journal of biochemistry & cell biology 40 21550419
1993 Interaction of Escherichia coli ribosomal protein S7 with 16S rRNA. Nucleic acids research 39 7681943
2003 A functional interaction between ribosomal proteins S7 and S11 within the bacterial ribosome. The Journal of biological chemistry 38 12937172
1980 Effect of ultraviolet irradiation on 30-S ribosomal subunits. Identification of the RNA region crosslinked to protein S7. European journal of biochemistry 37 6989601
2006 Fusion of carbohydrate binding modules from Thermotoga neapolitana with a family 10 xylanase from Bacillus halodurans S7. Extremophiles : life under extreme conditions 34 17006740
1994 Post-transcriptional regulation of the str operon in Escherichia coli. Structural and mutational analysis of the target site for translational repressor S7. Journal of molecular biology 34 8289236
2020 Circular RNA S-7 promotes ovarian cancer EMT via sponging miR-641 to up-regulate ZEB1 and MDM2. Bioscience reports 33 32667627
2000 Phylogenetic analysis of the S7 gene does not segregate Chinese strains of bluetongue virus into a single topotype. Archives of virology 33 10948989
1990 Cotranscription of the wild-type chloroplast atpE gene encoding the CF1/CF0 epsilon subunit with the 3' half of the rps7 gene in Chlamydomonas reinhardtii and characterization of frameshift mutations in atpE. Molecular & general genetics : MGG 32 2196429
1989 Sequence analysis of the peptide-elongation factor EF-2 gene, downstream from those of ribosomal proteins H-S12 and H-S7, from the archaebacterial extreme halophile, Halobacterium halobium. European journal of biochemistry 32 2513185
1993 Characterization of the S7 ribosomal protein gene in wheat mitochondria. Molecular & general genetics : MGG 31 8437584
1999 Identification of a mammalian mitochondrial homolog of ribosomal protein S7. Biochemical and biophysical research communications 30 10581179
1998 Nuclear import and nucleolar accumulation of the human ribosomal protein S7 depends on both a minimal nuclear localization sequence and an adjacent basic region. Biochemical and biophysical research communications 30 9731210
2020 Ribosomal protein S7 ubiquitination during ER stress in yeast is associated with selective mRNA translation and stress outcome. Scientific reports 29 33184379
2004 Assembly of the 30S ribosomal subunit: positioning ribosomal protein S13 in the S7 assembly branch. RNA (New York, N.Y.) 29 15525707
1991 A paradigm for local conformational control of function in the ribosome: binding of ribosomal protein S19 to Escherichia coli 16S rRNA in the presence of S7 is required for methylation of m2G966 and blocks methylation of m5C967 by their respective methyltransferases. Nucleic acids research 29 1766869
1987 Nucleotide sequence, promoter analysis, and linkage mapping of the unusually organized operon encoding ribosomal proteins S7 and S12 in maize chloroplast. The Journal of biological chemistry 29 2822717
1996 A functional role for some Fugu introns larger than the typical short ones: the example of the gene coding for ribosomal protein S7 and snoRNA U17. Nucleic acids research 28 8774896
1981 Apparent association constants for E. coli ribosomal proteins S4, S7, S8, S15, S17 and S20 binding to 16S RNA. Nucleic acids research 28 7029472
2011 Molecular characterization of segments S7 to S10 of a southern rice black-streaked dwarf virus isolate from maize in northern China. Virologica Sinica 27 21331890
1992 Photochemical cross-linking of the anticodon loop of yeast tRNA(Phe) to 30S-subunit protein S7 at the ribosomal A and P sites. Biochimie 27 1637863
2010 Indirect ELISA and indirect immunofluorescent antibody assay for detecting the antibody against murine norovirus S7 in mice. Experimental animals 26 20224169
1989 Analysis of lymphoid population in scid mice; detection of a potential B lymphocyte progenitor population present at normal levels in scid mice by three color flow cytometry with B220 and S7. Current topics in microbiology and immunology 26 2478339
1992 The yeast ribosomal protein S7 and its genes. The Journal of biological chemistry 25 1737755
1989 Ribosomal proteins S7 and L1 are located close to the decoding site of E. coli ribosome--affinity labeling studies with modified tRNAs carrying photoreactive probes attached adjacent to the 3'-end of the anticodon. Nucleic acids research 25 2685749
2019 Kinase PIM1 promotes prostate cancer cell growth via c-Myc-RPS7-driven ribosomal stress. Carcinogenesis 24 30247545
2009 Yeast strains with N-terminally truncated ribosomal protein S5: implications for the evolution, structure and function of the Rps5/Rps7 proteins. Nucleic acids research 24 19969550
2000 Tagging ribosomal protein S7 allows rapid identification of mutants defective in assembly and function of 30 S subunits. Journal of molecular biology 24 10772857
2014 Molecular network including eIF1AX, RPS7, and 14-3-3γ regulates protein translation and cell proliferation in bovine mammary epithelial cells. Archives of biochemistry and biophysics 23 25281768
2006 Cloning, sequence analysis, and expression of a gene encoding an endoxylanase from Bacillus halodurans S7. Molecular biotechnology 23 16757802
1998 Matching the crystallographic structure of ribosomal protein S7 to a three-dimensional model of the 16S ribosomal RNA. RNA (New York, N.Y.) 23 9582096
1994 Mutational and structural analysis of the RNA binding site for Escherichia coli ribosomal protein S7. Journal of molecular biology 23 7525976
1984 Comparative electron microscopic study on the location of ribosomal proteins S3 and S7 on the surface of the E. coli 30S subunit using monoclonal and conventional antibody. Molecular & general genetics : MGG 23 6394951
2013 Ribosomal protein S7 regulates arsenite-induced GADD45α expression by attenuating MDM2-mediated GADD45α ubiquitination and degradation. Nucleic acids research 22 23563151
2001 Ribosomal protein S7 from Escherichia coli uses the same determinants to bind 16S ribosomal RNA and its messenger RNA. Nucleic acids research 22 11160889
1995 The single-ring Thermoanaerobacter brockii chaperonin 60 (Tbr-EL7) dimerizes to Tbr-EL14.Tbr-ES7 under protein folding conditions. Biochemistry 22 7578105
2007 Molecular analysis of the genome segments S1, S4, S6, S7 and S12 of a Rice gall dwarf virus isolate from Thailand; completion of the genomic sequence. Archives of virology 21 17426918
1983 Electron microscopic investigations on the location of rat liver ribosomal proteins S3a, S5, S6, S7 and S9 by means of antibody labeling. Biomedica biochimica acta 21 6196023
2024 RNA-binding protein RPS7 promotes hepatocellular carcinoma progression via LOXL2-dependent activation of ITGB1/FAK/SRC signaling. Journal of experimental & clinical cancer research : CR 20 38326908
2019 RPS7 promotes cell migration through targeting epithelial-mesenchymal transition in prostate cancer. Urologic oncology 20 30737160
2001 Chloroplast ribosomal protein S7 of Chlamydomonas binds to chloroplast mRNA leader sequences and may be involved in translation initiation. The Plant cell 20 11158540
2017 ES7, encoding a ferredoxin-dependent glutamate synthase, functions in nitrogen metabolism and impacts leaf senescence in rice. Plant science : an international journal of experimental plant biology 19 28483051
1997 Specific interactions of the autoantigen L7 with multi-zinc finger protein ZNF7 and ribosomal protein S7. The Journal of biological chemistry 19 9268371
1997 Rice ragged stunt oryzavirus genome segments S7 and S10 encode non-structural proteins of M(r) 68,025 (Pns7) and M(r) 32,364 (Pns10). Archives of virology 19 9672632
2015 Stabilization of SIRT7 deacetylase by viral oncoprotein HBx leads to inhibition of growth restrictive RPS7 gene and facilitates cellular transformation. Scientific reports 18 26442981
1986 Multiple crosslinks of proteins S7, S9, S13 to domains 3 and 4 of 16S RNA in the 30S particle. Nucleic acids research 18 2423965
2019 Identification of a novel membrane-associated protein from the S7 segment of grass carp reovirus. The Journal of general virology 17 30688636
2000 Proteins S7, S10, S16 and S19 of the human 40S ribosomal subunit are most resistant to dissociation by salt. Biochimica et biophysica acta 17 11121577
2003 The S7 gene and VP7 protein are highly conserved among temporally and geographically distinct American isolates of epizootic hemorrhagic disease virus. Virus research 16 12902042
1988 Protein binding sites on Escherichia coli 16S ribosomal RNA; RNA regions that are protected by proteins S7, S9 and S19, and by proteins S8, S15 and S17. Nucleic acids research 16 3279390
1987 Protein binding sites on Escherichia coli 16S RNA; RNA regions that are protected by proteins S7, S14 and S19 in the presence or absence of protein S9. Nucleic acids research 16 2438658
2021 Cellular Trafficking of Glutathione Transferase M2-2 Between U373MG and SHSY-S7 Cells is Mediated by Exosomes. Neurotoxicity research 14 33555546
1995 The phosphorylated ribosomal protein S7 in Tetrahymena is homologous with mammalian S4 and the phosphorylated residues are located in the C-terminal region. Structural characterization of proteins separated by two-dimensional polyacrylamide gel electrophoresis. The Journal of biological chemistry 14 7890730
1980 Analysis of rpsD mutations in Escherichia coli. IV. Accumulation of minor forms of protein S7(K) in ribosomes of rpsD mutant strains due to translational read-through. Molecular & general genetics : MGG 14 6990204
1979 The primary structure of ribosomal protein S7 from E. coli strains K and B. Biochimie 14 385062
2009 Phylogenetic relationships of North American phoxinins (Actinopterygii: Cypriniformes: Leuciscidae) as inferred from S7 nuclear DNA sequences. Molecular phylogenetics and evolution 13 19909821
1991 The nucleotide sequences of Bacillus stearothermophilus ribosomal protein S12 and S7 genes: comparison with the str operon of Escherichia coli. Agricultural and biological chemistry 13 1368664
2020 A novel biphenyl compound IMB-S7 ameliorates hepatic fibrosis in BDL rats by suppressing Sp1-mediated integrin αv expression. Acta pharmacologica Sinica 12 31932644
2017 BCCIPβ modulates the ribosomal and extraribosomal function of S7 through a direct interaction. Journal of molecular cell biology 12 28510697
1990 The primary structure of rat ribosomal protein S7. FEBS letters 12 2226813
2022 BmCPV-Derived Circular DNA vcDNA-S7 Mediated by Bombyx mori Reverse Transcriptase (RT) Regulates BmCPV Infection. Frontiers in immunology 11 35371040
2022 Baicalein Inhibits the SMYD2/RPS7 Signaling Pathway to Inhibit the Occurrence and Metastasis of Lung Cancer. Journal of oncology 11 35432530
2010 Deletion of the RluD pseudouridine synthase promotes SsrA peptide tagging of ribosomal protein S7. Molecular microbiology 11 21219455
2009 Molecular phylogenetics of North American phoxinins (Actinopterygii: Cypriniformes: Leuciscidae) based on RAG1 and S7 nuclear DNA sequence data. Molecular phylogenetics and evolution 11 20040376
1995 The human ribosomal protein S7-encoding gene: isolation, structure and localization in 2p25. Gene 11 8522193
1986 Different alterations of the ribosomal protein S7 lead to opposite effects on translational fidelity in the fungus Podospora anserina. The Journal of biological chemistry 10 3949806
1981 Effect of bile acid derivatives on taurine biosynthesis and extracellular slime production in encapsulated Staphylococcus aureus S-7. Infection and immunity 10 7216475