Affinage

RPS26

Small ribosomal subunit protein eS26 · UniProt P62854

Length
115 aa
Mass
13.0 kDa
Annotated
2026-06-10
48 papers in source corpus 17 papers cited in narrative 20 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/7 claims corpus-supported (86%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

RPS26/eS26 is an essential component of the eukaryotic 40S ribosomal subunit that occupies the mRNA exit channel and confers transcript-selective control over translation (PMID:28759050, PMID:22167470). Through its eukaryote-specific YxxPKxYxK motif (residues ~60–71) and C-terminal tail, it directly contacts mRNA at positions upstream of the E-site codon (-3 to -16 relative to the start codon), placing it at the mRNA-binding channel 5' of the E site (PMID:22167470, PMID:37013984, PMID:15612591), a position first localized by affinity labeling at the ribosomal mRNA-binding site (PMID:6708946). This motif overlaps the footprint of initiation factor eIF3, and its mutation shifts polysome distribution and eIF3e content, indicating a role in fine-tuning selective translation (PMID:35817369). Functionally, C-terminal mRNA binding exerts positive control over Kozak-driven and negative control over TISU-driven translation, and links ribosome function to energy metabolism through mTOR and AMPK signaling (PMID:37013984). RPS26 is required for 18S rRNA processing at the 18S-E step and for 40S subunit assembly and 80S formation, and its loss-of-function mutations cause Diamond-Blackfan anemia (PMID:20116044, PMID:27303706). Beyond a constitutive role, RPS26 defines a specialized ribosome state: the chaperone Tsr2 reversibly releases Rps26 from assembled ribosomes during osmotic/pH stress, with released Rps26 degraded via the Pro/N-degron pathway by the GID-complex E3 ligase, generating Rps26-deficient ribosomes that preferentially translate stress-response mRNAs in a feed-forward loop (PMID:28759050, PMID:35213229). RPS26 additionally functions outside the ribosome: it stabilizes p53 by binding Mdm2 and inhibiting p53 ubiquitination while co-existing in a p53/p300 complex to promote p53 transcriptional activity and DNA-damage-induced G2/M arrest (PMID:23728348), autoregulates its own expression by binding and suppressing splicing of its pre-mRNA (PMID:15716004), and contacts the NMD factor Upf1 via the Upf1 CH domain on the 40S subunit (PMID:23801788).

Mechanistic history

Synthesis pass · year-by-year structured walk · 20 steps
  1. 1984 Medium

    Established that the S26 ribosomal protein physically resides at the mRNA-binding site of the ribosome, the first localization placing it in the translational path of mRNA.

    Evidence Affinity labeling with an alkylating oligonucleotide analogue on rat liver ribosomes, with poly(U) competition

    PMID:6708946

    Open questions at the time
    • Did not define which mRNA positions contact the protein
    • No residue-level mapping of the contact
  2. 2004 Medium

    Resolved where on the mRNA RPS26 sits, identifying it as the principal protein neighboring mRNA 5' of the E-site codon (positions -4 to -9).

    Evidence Site-directed UV cross-linking with photoactivatable mRNA analogues in human 80S complexes

    PMID:15612591

    Open questions at the time
    • Did not identify the protein region responsible
    • Functional consequence of the contact untested
  3. 2005 Medium

    Showed RPS26 is autoregulatory at the splicing level, binding its own pre-mRNA to suppress splicing, establishing a feedback control of its own abundance.

    Evidence In vitro binding (nitrocellulose filtration), in vitro splicing suppression with recombinant protein, toe-printing of binding sites

    PMID:15716004

    Open questions at the time
    • In vitro reconstitution not confirmed in cells
    • Stoichiometry/threshold for autoregulation undefined
  4. 2006 Medium

    Demonstrated that RPS26 dosage controls translation of a specific mRNA (FLO11), an early indication of transcript-selective function rather than uniform ribosome activity.

    Evidence Yeast single/double deletion strains, FLO11-lacZ reporter, northern blot, complementation

    PMID:16721598

    Open questions at the time
    • Mechanism of selectivity for FLO11 mRNA unresolved
    • Restricted to a yeast paralog (RPS26A vs RPS26B)
  5. 2010 High

    Linked RPS26 to human disease and to a defined biogenesis step, showing its mutations cause Diamond-Blackfan anemia and that it is required for 18S rRNA processing at the 18S-E step.

    Evidence Pre-rRNA analysis in patient lymphoblastoid cells and siRNA knockdown in HeLa with northern blot

    PMID:20116044

    Open questions at the time
    • Mechanism connecting processing defect to erythroid phenotype not defined
    • Does not separate biogenesis from translational roles
  6. 2011 High

    Identified the eukaryote-specific YxxPKxYxK motif as the structural element making direct mRNA contact (positions -3 to -9), explaining how RPS26 reads sequence near the start codon.

    Evidence Site-directed cross-linking with mRNA analogues and proteolytic peptide mapping on human 80S, plus X-ray analysis of Tetrahymena 40S

    PMID:22167470

    Open questions at the time
    • Functional output of the contact not yet measured
    • Sequence preference of the motif not defined
  7. 2013 Medium

    Revealed an extra-ribosomal role in the p53 pathway, with RPS26 binding Mdm2 to inhibit p53 ubiquitination and forming a p53/p300 complex to support p53 transactivation and DNA-damage checkpoint arrest.

    Evidence siRNA knockdown, reciprocal Co-IP, p53 ubiquitination assay, ChIP, cell-cycle analysis

    PMID:23728348

    Open questions at the time
    • Single-lab finding without independent replication
    • Whether free or ribosome-bound RPS26 mediates this is unclear
  8. 2013 Medium

    Connected RPS26 to mRNA surveillance, showing the NMD factor Upf1 binds Rps26 of the 40S subunit via its CH domain in an ATP-dependent, factor-independent manner.

    Evidence Two-hybrid screen, in vitro binding, Co-IP with tagged 40S, Upf1 domain mapping

    PMID:23801788

    Open questions at the time
    • Functional role of the interaction in NMD not established
    • Not reciprocally validated beyond this lab
  9. 2016 Medium

    Distinguished RPS26's biogenesis role from translation, showing the YxxPKxYxK segment is essential for viability and required for 40S assembly/80S formation, with free 60S accumulation upon mutation.

    Evidence Alanine-scanning mutagenesis, polysome profiling, growth assays, and human RPS26 complementation in S. cerevisiae

    PMID:27303706

    Open questions at the time
    • Single substitutions had no effect, leaving residue-level function ambiguous
    • Yeast vs human functional equivalence only partly resolved
  10. 2017 High

    Established the central concept of specialized Rps26-deficient ribosomes, showing Rps26 reads the Kozak context and that stress generates Rps26-deficient ribosomes that selectively translate stress-response mRNAs in a feed-forward loop.

    Evidence Separation of Rps26+/- ribosome populations with RNA-seq plus genetic/biochemical analysis in S. cerevisiae

    PMID:28759050

    Open questions at the time
    • Mechanism of Rps26 removal from mature ribosomes not yet defined here
    • Generality across mammalian systems untested at this stage
  11. 2018 Medium

    Identified a biogenesis-export function, with the eS26 C-terminus required for nucleophosmin binding to 40S subunits, linking it to nuclear export of pre-40S particles.

    Evidence Inducible FLAG-eS26 expression with polysome fractionation and in vitro binding with recombinant nucleophosmin in HeLa nuclear extract

    PMID:29563070

    Open questions at the time
    • Export defect not directly demonstrated upon C-terminal loss
    • Phosphorylation dependence inferred from extract conditions
  12. 2018 Medium

    Showed an in vivo physiological requirement, with oocyte-specific Rps26 knockout arresting chromatin transition and signaling and causing premature ovarian failure.

    Evidence Conditional knockout mouse with histology, immunofluorescence, and signaling western blots

    PMID:30451825

    Open questions at the time
    • Whether phenotype is from general ribosome loss or a selective translation defect is unresolved
    • Specific target mRNAs not identified
  13. 2022 High

    Defined the molecular machinery that produces specialized ribosomes, showing the chaperone Tsr2 reversibly releases Rps26 under high Na+/elevated pH, stores it, and reincorporates it after stress.

    Evidence In vitro Tsr2-mediated release assay, in vivo Tsr2 deletion, ribosome fractionation, site-directed mutagenesis of a DBA-associated residue

    PMID:35213229

    Open questions at the time
    • Sensing mechanism converting ionic change to release not fully resolved
    • Mammalian conservation of the Tsr2 mechanism untested here
  14. 2022 Medium

    Refined the mammalian translational consequence, showing the YxxPKxYxK motif contacts the same mRNA residues as eIF3 and its mutation alters polysome distribution and eIF3e content.

    Evidence Cross-linking on mammalian 80S, FLAG-eS26 transfection in HEK293T, polysome profiling with western and qPCR

    PMID:35817369

    Open questions at the time
    • Direct competition between eS26 and eIF3 not demonstrated
    • Specific target transcripts not enumerated
  15. 2022 Medium

    Tied RPS26 loss to the disease-relevant cell type, showing deficiency in erythroid progenitors causes rRNA imbalance, apoptosis, calcium elevation, and impaired differentiation.

    Evidence siRNA knockdown in HUDEP-1 cells with rRNA analysis, flow cytometry, and calcium measurement

    PMID:36579335

    Open questions at the time
    • Causal chain from rRNA imbalance to apoptosis not dissected
    • Selective vs global translation effects not separated
  16. 2023 High

    Mapped the C-terminal mRNA contact (positions -10 to -16) to opposite translational outcomes on Kozak vs TISU mRNAs and connected RPS26 to cellular energy/stress signaling.

    Evidence CRISPR-Cas9 C-terminal mutant (RPS26dC), ribosome profiling, Kozak/TISU reporters, glucose-starvation and mTOR/AMPK assays

    PMID:37013984

    Open questions at the time
    • Direct mechanism linking C-terminal mRNA binding to mTOR/AMPK unresolved
    • Element-specificity rules for selectivity incomplete
  17. 2024 High

    Completed the specialized-ribosome cycle by identifying the degradation route, showing released Rps26 is polyubiquitinated by the GID-complex/Gid4 via the Pro/N-degron pathway, enabling Tsr2 recycling and Rps26-deficient ribosome accumulation.

    Evidence Yeast genetics (N-terminal proline substitution, GID/Gid4 deletion), ubiquitination assays, polysome profiling, salt-stress assays (preprint)

    Open questions at the time
    • Preprint not yet peer-reviewed
    • Mammalian conservation of the degron pathway untested
  18. 2024 Medium

    Provided structural context for conservation, with archaeal cryo-EM showing eS26 in the mRNA exit channel wrapped around rRNA 3' end and incompatible with SD:antiSD pairing.

    Evidence Cryo-EM of archaeal small subunit initiation complexes (preprint)

    Open questions at the time
    • No mutagenesis validation of archaeal eS26 function
    • Preprint not yet peer-reviewed
  19. 2025 Medium

    Extended RPS26's selective-translation role to repeat-associated translation, showing it is enriched on CGG-expanded FMR1 RNA and modulates FMRpolyG production, with insufficiency preferentially affecting short GC-rich 5'UTR mRNAs.

    Evidence RNA-tagging/mass spectrometry, siRNA knockdown of RPS26 and TSR2, FMRpolyG assay, translatome analysis

    PMID:40377206

    Open questions at the time
    • Direct mechanism of RAN translation modulation not defined
    • Single-study finding
  20. 2025 Low

    Raised a new function in termination fidelity, correlating Rps26 stoichiometry with tissue-specific termination pausing and stop-codon slippage.

    Evidence Terminating ribosome profiling and parallel reporter assays in mammalian cells (preprint)

    Open questions at the time
    • Correlational only; Rps26 levels not directly manipulated to test causality
    • Preprint not yet peer-reviewed

Open questions

Synthesis pass · forward-looking unresolved questions
  • How RPS26's many roles—exit-channel mRNA reading, biogenesis, p53 regulation, NMD contact, and stress-induced ribosome remodeling—are coordinated and which are direct versus secondary to ribosome dysfunction remains unresolved.
  • No unified model distinguishing on-ribosome from extra-ribosomal functions
  • Mammalian conservation of the Tsr2/GID specialized-ribosome cycle not established
  • Rules governing transcript selectivity by RPS26 incompletely defined

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0003723 RNA binding 4 GO:0045182 translation regulator activity 3 GO:0005198 structural molecule activity 2
Localization
GO:0005840 ribosome 3 GO:0005730 nucleolus 1
Pathway
R-HSA-8953897 Cellular responses to stimuli 3 R-HSA-8953854 Metabolism of RNA 2
Partners
EP300GID4MDM2NPM1TP53TSR2UPF1
Complex memberships
40S ribosomal subunitRps26-Tsr2 complex

Evidence

Reading pass · 20 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2017 Yeast Rps26 contributes to mRNA-specific translation by recognition of the Kozak sequence in well-translated mRNAs; Rps26-deficient ribosomes preferentially translate mRNAs from select stress-response pathways. Exposure to stress leads to formation of Rps26-deficient ribosomes and increased translation of their target mRNAs, establishing a feed-forward translational stress response loop. Separation of two ribosome populations (with and without Rps26) from same cells combined with RNA-seq; genetic and biochemical analysis in S. cerevisiae Nature structural & molecular biology High 28759050
2022 The chaperone Tsr2 releases Rps26 from fully assembled ribosomes in the presence of high Na+ or elevated pH in vitro, and is required for Rps26 release in vivo during osmotic/pH stress. Tsr2 stores free Rps26 and promotes its reincorporation into ribosomes after stress subsides, enabling a reversible ribosome population change. A DBA-associated residue in Rps26 mediates the Na+ effect. In vitro biochemical assay (Tsr2-mediated Rps26 release), in vivo yeast genetics (Tsr2 deletion), ribosome fractionation, site-directed mutagenesis Science advances High 35213229
2024 Released Rps26 (from the Rps26•Tsr2 complex during high-salt stress) is degraded via the Pro/N-degron pathway. The GID-complex E3 ubiquitin ligase and its adaptor Gid4 mediate polyubiquitination of Rps26 at Lys66 and Lys70, enabling Tsr2 recycling, accumulation of Rps26-deficient ribosomes to ~50% of total, and high-salt stress resistance. Yeast genetics (N-terminal proline substitution, GID-complex/Gid4 deletion), ubiquitination assays, polysome profiling, salt-stress phenotype assays bioRxivpreprint High
2013 RPS26 knockdown induces p53 stabilization via an RPL11-dependent mechanism. RPS26 protein interacts with Mdm2 and inhibits Mdm2-mediated p53 ubiquitination. RPS26 also interacts with p53 independently of Mdm2 and co-exists in a complex with p53 and p300. RPS26 knockdown impairs p53 transcriptional activity, p53 acetylation, and recruitment of p53 to target gene promoters in response to DNA damage, abolishing G2/M arrest. siRNA knockdown in cells, Co-immunoprecipitation, p53 ubiquitination assay, ChIP assay, cell cycle analysis Oncogene Medium 23728348
2013 Upf1 (NMD regulator) interacts specifically with Rps26 of the 40S ribosomal subunit. This interaction is mediated by the N-terminal CH domain of Upf1, is dependent on ATP, and occurs without simultaneous association of eRF1, eRF3, Upf2, or Upf3. Two-hybrid screen, in vitro binding assay, coimmunoprecipitation with epitope-tagged 40S subunits, domain mapping with UPF1 mutations RNA (New York, N.Y.) Medium 23801788
2010 Mutations in RPS26 cause Diamond-Blackfan anemia (DBA). Lymphoblastoid cells from patients with RPS26 mutations show elevated 18S-E pre-rRNA, and siRNA knockdown of RPS26 in HeLa cells phenocopies this, indicating RPS26 is required for 18S rRNA processing at the 18S-E step. Pre-rRNA analysis in patient lymphoblastoid cells; siRNA knockdown in HeLa cells with pre-rRNA northern blot American journal of human genetics High 20116044
2005 Human RPS26 protein binds to the first intron and mRNA fragment of its own pre-mRNA (detected by nitrocellulose filtration). Recombinant RPS26 suppresses in vitro splicing of both conventional and alternative RPS26 mRNAs. Toe-printing mapped RPS26 binding to two clusters in the pre-mRNA secondary structure flanking the conventional and alternative 3' splice sites, establishing an autoregulatory feedback mechanism at the level of pre-mRNA splicing. Nitrocellulose filtration binding assay, in vitro splicing assay with recombinant protein and HeLa nuclear extract, toe-printing Biochimica et biophysica acta Medium 15716004
2011 The eukaryote-specific motif YxxPKxYxK (fragment 60–71) of human rpS26e directly contacts mRNA at positions -3 to -9 relative to the E-site codon on the 80S ribosome, establishing this region as part of the mRNA binding channel 5' of the E site. X-ray structural analysis showed this motif is not involved in intraribosomal contacts, implying its function in translation. Site-directed cross-linking with mRNA analogues bearing perfluorophenyl azide at defined positions, proteolytic mapping of cross-linked peptides in human 80S ribosomal complexes, X-ray structural analysis of Tetrahymena thermophila 40S subunit Nucleic acids research High 22167470
2023 RPS26 C-terminal domain binds mRNA at positions -10 to -16 (AUG upstream nucleotides at the exit channel). This binding exerts positive effects on Kozak-driven translation and negative effects on TISU-driven translation. CRISPR-Cas9 mutation of the RPS26 C-terminus (RPS26dC) confers resistance to glucose starvation and mTOR inhibition, reduces basal mTOR activity, and activates AMPK, linking RPS26 C-terminal RNA binding to energy metabolism and translational stress responses. CRISPR-Cas9 mutagenesis of RPS26 C-terminus, translatome analysis (ribosome profiling/RNA-seq), reporter assays with Kozak/TISU elements, glucose starvation and mTOR inhibition assays, AMPK/mTOR activity measurements Nucleic acids research High 37013984
2016 The eukaryote-specific Y62-K70 (YxxPKxYxK) segment of Rps26 is essential for viability (complete deletion is lethal), and simultaneous alanine substitution of five conserved residues within this segment causes growth defects and accumulation of free 60S subunits (indicating impaired 80S assembly). Single-amino-acid substitutions in this motif did not affect function. Human Rps26 expressed in yeast supports growth but causes altered 40S/60S ratios, indicating a role for Rps26 in 40S subunit assembly and 80S ribosome formation rather than specifically in translation initiation. Alanine-scanning mutagenesis in S. cerevisiae, polysome profiling, growth assays under stress conditions, complementation with human RPS26 mSphere Medium 27303706
2022 The eukaryote-specific YxxPKxYxK motif of human eS26 contacts the same mRNA nucleotide residues as translation initiation factor eIF3 on mammalian 80S ribosomes. Simultaneous replacement of all five conserved residues (5A mutant) increases the light polysome fraction and enhances eIF3e content in that fraction, suggesting involvement of this motif in fine-tuning selective translation. Site-directed cross-linking on mammalian 80S ribosomes, transfection of HEK293T cells with FLAG-tagged wild-type or mutant eS26 constructs, polysome profiling with western blot analysis, real-time PCR Biochimica et biophysica acta. Gene regulatory mechanisms Medium 35817369
2018 The C-terminus of eS26 is required for nucleophosmin binding to the 40S ribosomal subunit. FLAG-tagged eS26 incorporates into 40S subunits without affecting ribosome assembly or translational activity, but eS26FLAG-containing ribosome fractions show reduced nucleophosmin content. Direct binding of nucleophosmin to isolated eS26 and to 40S subunits was demonstrated with recombinant protein in the presence of HeLa nuclear extract (which phosphorylates nucleophosmin), implicating the eS26 C-terminus in the mRNA exit site region for nucleophosmin-dependent nuclear export of pre-40S subunits. Doxycycline-inducible expression of C-terminally FLAG-tagged eS26 in HEK293-derived cells, polysome fractionation with western blot, in vitro binding assay with recombinant nucleophosmin and HeLa nuclear extract Biochimica et biophysica acta. Proteins and proteomics Medium 29563070
1984 Ribosomal protein S26 is located at the mRNA binding site of rat liver ribosomes, as established by affinity labeling with a radioactive alkylating heptauridylate derivative; labeling was abolished by competing poly(U). Affinity labeling with radioactive alkylating oligonucleotide analogue on rat liver ribosomes; competition with poly(U) Molecular biology reports Medium 6708946
2004 mRNA positions -4 to -9 (5' of the E-site codon) on the human 80S ribosome are primarily cross-linked to protein S26, establishing S26 as the principal ribosomal protein neighboring mRNA 5' of the E site codon. Site-directed UV cross-linking with photoactivatable mRNA analogues positioned in human 80S ribosomal complexes; protein identification by gel analysis Molekuliarnaia biologiia Medium 15612591
2006 RPS26A (but not RPS26B) in S. cerevisiae is required for FLO11-mediated haploid adhesive and diploid pseudohyphal growth. FLO11-lacZ activity is absent in rps26AΔ strains despite normal FLO11 mRNA levels, indicating that Rps26 amount is critical for accurate translation of FLO11 mRNA and the dimorphic switch. Overexpression of RPS26B or RPS26B driven by the RPS26A promoter complements this defect, indicating the proteins are functionally interchangeable when expressed at sufficient levels. Yeast genetics (single and double deletion strains), reporter assays (FLO11-lacZ), northern blot for FLO11 mRNA, complementation experiments Molecular genetics and genomics Medium 16721598
2025 Depletion of RPS26 (and its chaperone TSR2) modulates FMRpolyG production from CGG-repeat-expanded FMR1 mRNA (repeat-associated non-AUG translation). RPS26 was identified as enriched on CGG-expanded FMR1 RNA by RNA-tagging/mass spectrometry. RPS26 insufficiency preferentially impacts translation of mRNAs with short, GC-rich 5'UTRs. RNA-tagging and mass spectrometry screening for proteins enriched on CGGexp FMR1 RNA; siRNA knockdown of RPS26 and TSR2; FMRpolyG production assay; translatome analysis eLife Medium 40377206
2025 Tissue-specific patterns of ribosome termination pausing correlate with the stoichiometry of Rps26, which modulates mRNA:rRNA interactions at the stop codon. Reduced Rps26 levels are associated with altered termination pausing and increased stop codon slippage. Terminating ribosome profiling in mammalian cells; massively parallel reporter assays; correlation of Rps26 stoichiometry with termination pausing patterns across tissues bioRxivpreprint Low
2024 Cryo-EM structures of archaeal (Saccharolobus solfataricus) small ribosomal subunit initiation complexes show archaeal eS26 positioned in the mRNA exit channel wrapped around the 3' end of ribosomal RNA, as in eukaryotes, and its position is incompatible with an SD:antiSD duplex in the exit channel, suggesting a conserved role of eS26 in translation regulation. Cryo-EM structure determination of archaeal ribosomal initiation complexes bioRxivpreprint Medium
2022 RPS26 deficiency in human erythroid progenitor cells (HUDEP-1) causes imbalanced ribosomal RNA production, upregulation of pro-apoptotic genes, reduced cell viability, increased intracellular calcium, and impaired erythroid differentiation. siRNA knockdown of RPS26 in HUDEP-1 cells; rRNA analysis; flow cytometry for erythroid markers and apoptosis; calcium measurement Frontiers in genetics Medium 36579335
2018 Specific knockout of Rps26 in mouse oocytes arrests chromatin configuration at the NSN-to-SN transition, decreases mRNA transcription, reduces H3K4/H3K9 trimethylation and DNA methylation, lowers oocyte-derived growth factors (GDF9, BMP15, CX37), and disrupts PI3K/AKT/FOXO3a signaling, causing premature ovarian failure. Conditional knockout mouse (oocyte-specific Rps26 deletion), histology, immunofluorescence for histone modifications and DNA methylation, western blot for signaling pathway components Cell death & disease Medium 30451825

Source papers

Stage 0 corpus · 48 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1993 S26 ribosomal protein RNA: an invariant control for gene regulation experiments in eucaryotic cells and tissues. Nucleic acids research 206 8464749
2010 Ribosomal protein genes RPS10 and RPS26 are commonly mutated in Diamond-Blackfan anemia. American journal of human genetics 192 20116044
2017 Rps26 directs mRNA-specific translation by recognition of Kozak sequence elements. Nature structural & molecular biology 119 28759050
2013 The ribosomal protein S26 regulates p53 activity in response to DNA damage. Oncogene 94 23728348
1977 Isolation of eukaryotic ribosomal proteins. Purification and characterization of the 40 S ribosomal subunit proteins Sa, Sc, S3a, S3b, S5', S9, S10, S11, S12, S14, S15, S15', S16, S17, S18, S19, S20, S21, S26, S27', and S29. The Journal of biological chemistry 60 925037
2018 Loss of oocyte Rps26 in mice arrests oocyte growth and causes premature ovarian failure. Cell death & disease 46 30451825
2022 The chaperone Tsr2 regulates Rps26 release and reincorporation from mature ribosomes to enable a reversible, ribosome-mediated response to stress. Science advances 42 35213229
1996 Photoreceptor protein s26, a cone homologue of S-modulin in frog retina. The Journal of biological chemistry 37 8702916
1985 Molecular cloning and nucleotide sequence of DNA complementary to rat ribosomal protein S26 messenger RNA. Journal of biochemistry 37 2993263
2013 Yeast Upf1 CH domain interacts with Rps26 of the 40S ribosomal subunit. RNA (New York, N.Y.) 32 23801788
2005 Human ribosomal protein S26 suppresses the splicing of its pre-mRNA. Biochimica et biophysica acta 30 15716004
2003 Expression and purification of human ribosomal proteins S3, S5, S10, S19, and S26. Protein expression and purification 26 12651107
2005 Purification and characterization of exo-beta-D-glucosaminidase from Aspergillus fumigatus S-26. Protein expression and purification 24 16289917
2011 A central fragment of ribosomal protein S26 containing the eukaryote-specific motif YxxPKxYxK is a key component of the ribosomal binding site of mRNA region 5' of the E site codon. Nucleic acids research 21 22167470
2006 FLO11 mediated filamentous growth of the yeast Saccharomyces cerevisiae depends on the expression of the ribosomal RPS26 genes. Molecular genetics and genomics : MGG 18 16721598
1984 Affinity labelling of rat liver ribosomal protein S26 by heptauridylate containing a 5'-terminal alkylating group. Molecular biology reports 18 6708946
1980 Purification of Drosophila ribosomal proteins. Isolation of proteins S8, S13, S14, S16, S19, S20/L24, S22/L26, S24, S25/S27, S26, S29, L4, L10/L11, L12, L13, L16, L18, L19, L27, 1, 7/8, 9, and 11. Biochemistry 16 6773542
1984 Esterase-26 (ES-26): characterization and genetic location on chromosome 3 of an eserine-sensitive esterase of the house mouse (Mus musculus). Biochemical genetics 11 6529441
2009 Structural motifs of the bacterial ribosomal proteins S20, S18 and S16 that contact rRNA present in the eukaryotic ribosomal proteins S25, S26 and S27A, respectively. Nucleic acids research 9 20034956
2023 Translation regulation of specific mRNAs by RPS26 C-terminal RNA-binding tail integrates energy metabolism and AMPK-mTOR signaling. Nucleic acids research 8 37013984
2016 Ribosomal Protein Rps26 Influences 80S Ribosome Assembly in Saccharomyces cerevisiae. mSphere 8 27303706
2023 Identification of novel mutations in patients with Diamond-Blackfan anemia and literature review of RPS10 and RPS26 mutations. International journal of laboratory hematology 7 37376976
1998 Isolation, structural analysis and mapping of the functional gene of human ribosomal protein S26. Gene 7 9602156
1993 The sucrase-isomaltase structural gene (Si-s) and a regulatory gene (Si-r) are closely linked to esterase-26 (Es-26) on mouse chromosome 3. Mammalian genome : official journal of the International Mammalian Genome Society 7 8118103
2022 Deficiency of ribosomal protein S26, which is mutated in a subset of patients with Diamond Blackfan anemia, impairs erythroid differentiation. Frontiers in genetics 6 36579335
2019 Identification of a novel RPS26 nonsense mutation in a Chinese Diamond-Blackfan Anemia patient. BMC medical genetics 6 31277601
2025 Insufficiency of 40S ribosomal proteins, RPS26 and RPS25, negatively affects biosynthesis of polyglycine-containing proteins in fragile-X associated conditions. eLife 5 40377206
2023 Association of RPS26 gene polymorphism with different types of diabetes in Chinese individuals. Journal of diabetes investigation 5 38041572
2022 The functional role of the eukaryote-specific motif YxxPKxYxK of the human ribosomal protein eS26 in translation. Biochimica et biophysica acta. Gene regulatory mechanisms 5 35817369
2018 The eS26 protein is involved in the formation of a nucleophosmin binding site on the human 40S ribosomal subunit. Biochimica et biophysica acta. Proteins and proteomics 4 29563070
1994 The Saccharomyces cerevisiae homologue of ribosomal protein S26. Gene 4 7821815
2025 Single-cell RNA sequencing study reveals the potential role of the RPS26 gene in attention deficit hyperactivity disorder. Progress in neuro-psychopharmacology & biological psychiatry 3 40653146
2023 Marine actinomycete Streptomyces variabilis S26 as a biocontrol agent for vibriosis in shrimp larval rearing systems. Journal of basic microbiology 3 37906111
2021 Characterization of a Novel CaCO3-Forming Alkali-Tolerant Rhodococcus erythreus S26 as a Filling Agent for Repairing Concrete Cracks. Molecules (Basel, Switzerland) 3 34067627
2018 [Enhancer trapping nearby rps26 gene in zebrafish mediated by the Tol2 transposon and it's annotation]. Sheng wu gong cheng xue bao = Chinese journal of biotechnology 2 29577695
1994 [Cloning cDNA of human S26 ribosomal protein and determination of its primary structure]. Bioorganicheskaia khimiia 2 7945460
2024 A novel nonsense RPS26 mutation in a patient with Diamond-Blackfan anemia: a case report. Journal of medical case reports 1 39568018
2003 [Interaction of human S26 ribosomal protein with fragments of mRNA and pre-mRNA for this protein in Hela nuclear cell extracts]. Molekuliarnaia biologiia 1 14593928
2002 [Ribosomal protein binding with the first intron of the human ribosomal protein S26 pre-mRNA stimulates its interaction with proteins extracted from Hela cells]. Molekuliarnaia biologiia 1 12068637
2002 A simple and rapid PCR-based method to isolate complete small macronuclear minichromosomes from hypotrich ciliates: 5S rDNA and S26 ribosomal protein gene of Oxytricha (Sterkiella) nova. Protist 1 12125755
2026 RPS26 Expression as a Predictive Biomarker and Functional Modulator in Sublingual Immunotherapy for Japanese Cedar Pollinosis. International archives of allergy and immunology 0 41790586
2025 Transcriptome analysis and reverse engineering verification of SNZ3Val125Ile and Pho3Asn134Asp revealed the mechanism of adaptive laboratory evolution to increase the yield of tyrosol in Saccharomyces cerevisiae strain S26-AE2. Biotechnology for biofuels and bioproducts 0 40045317
2025 Right robotic-assisted thoracic surgery retrograde fissureless en bloc S2/6 bisegmentectomy. Multimedia manual of cardiothoracic surgery : MMCTS 0 40214307
2004 [Human ribosomal protein S26 inhibits splicing of its own pre-mRNA]. Molekuliarnaia biologiia 0 15456139
2004 [Part of the matrix on the 5' side from codon in the E-segment is close to protein S26 on the human 80S ribosome]. Molekuliarnaia biologiia 0 15612591
1998 [Cloning and structure-function analysis of the human S26 ribosomal protein gene]. Genetika 0 9612692
1995 [Mapping of the genes for ribosomal proteins S26, L19, and L32 on human chromosomes]. Bioorganicheskaia khimiia 0 8670309
1995 [The 5'-region of mink ribosomal protein S26 cDNA: sequencing and comparative analysis]. Bioorganicheskaia khimiia 0 8670311

Missed literature

Know a paper Affinage missed for RPS26? Flag it for the maintainers and the community.

No submissions yet.