Affinage

RAB23

Ras-related protein Rab-23 · UniProt Q9ULC3

Length
237 aa
Mass
26.7 kDa
Annotated
2026-04-28
80 papers in source corpus 26 papers cited in narrative 26 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

RAB23 is a small GTPase that functions as a negative regulator of Hedgehog signaling and a versatile mediator of membrane trafficking to primary cilia and the plasma membrane. It acts downstream of Smoothened and upstream of Gli transcription factors in a Su(Fu)-dependent manner to suppress Gli2 activator function and promote Gli3 repressor formation, and it regulates Smoothened levels within the cilium (PMID:11449277, PMID:16364285, PMID:22365972, PMID:20375059). RAB23 is activated by the Inturned–Fuzzy GEF complex, localizes to the plasma membrane, endosomes, and primary cilia in its GTP-bound state, and mediates ciliary delivery of receptors including dopamine D1R and EP4 via IFT-B/KIF17, while also participating in clathrin-coated vesicle formation through interactions with AP-2, PICALM, and endophilin A2 (PMID:31564489, PMID:26182404, PMID:41372612, PMID:40261407). Loss-of-function mutations in RAB23 cause Carpenter syndrome, a craniosynostosis-polydactyly disorder driven by context-dependent primary cilia dysfunction and deregulated FGF/ERK and Hedgehog signaling (PMID:17503333, PMID:32662771, PMID:40825043).

Mechanistic history

Synthesis pass · year-by-year structured walk · 14 steps
  1. 2001 High

    The foundational question of where RAB23 acts in development was answered when positional cloning of the mouse open brain locus revealed Rab23 as an essential negative regulator of Shh signaling, establishing the first link between a Rab GTPase and Hedgehog pathway control.

    Evidence Map-based cloning of opb locus and Shh/opb double-mutant epistasis in mouse

    PMID:11449277

    Open questions at the time
    • Mechanism of negative regulation unknown
    • Subcellular site of action unresolved
    • No direct biochemical target identified
  2. 2003 High

    Determining where RAB23 resides in the cell revealed plasma membrane and early endosome localization with GTP-state dependence, and showed Patched but not Smoothened colocalizes with Rab23 vesicles, narrowing the trafficking compartment involved.

    Evidence Live-cell fluorescence, immunoelectron microscopy, GFP-tagged WT/Q68L/S23N Rab23 in cultured cells

    PMID:14617350

    Open questions at the time
    • Ciliary localization not yet examined
    • No functional connection to Hh signaling components established biochemically
  3. 2005 High

    Genetic epistasis placed Rab23 downstream of Smoothened and identified Gli2 activator as its primary target, with additional promotion of Gli3 repressor, resolving the signaling hierarchy within the Hh pathway.

    Evidence Rab23/Gli2, Rab23/Gli3, Rab23/Smo double-mutant analysis in mouse

    PMID:16364285

    Open questions at the time
    • Direct biochemical mechanism linking Rab23 to Gli processing or trafficking unknown
    • Role of Su(Fu) not yet tested
  4. 2007 High

    Identification of RAB23 loss-of-function mutations in Carpenter syndrome families established the human disease consequence and confirmed the clinical relevance of RAB23-mediated Hedgehog regulation.

    Evidence Homozygosity mapping and sequencing of 15 Carpenter syndrome families

    PMID:17503333

    Open questions at the time
    • Cellular pathomechanism in cranial sutures undefined
    • Whether cilia defects underlie the syndrome not tested
  5. 2010 High

    The discovery that Rab23 depletion decreases Smoothened levels in the primary cilium revealed a specific ciliary trafficking function, connecting its GTPase activity to cilium-dependent Hh signaling.

    Evidence FRAP and siRNA/dominant-negative perturbation in MDCK cilia

    PMID:20375059

    Open questions at the time
    • Whether Rab23 itself enters cilia not established
    • Cargo specificity beyond Smoothened not tested
  6. 2012 High

    Two distinct roles emerged simultaneously: Rab23 directly associates with Su(Fu) to suppress Gli1 nuclear localization in a GTPase-dependent manner, providing the first biochemical partner in Hh regulation; and Rab23 participates in autophagosome formation targeting Group A Streptococcus independently of starvation autophagy.

    Evidence Co-IP of Rab23–Su(Fu), Gli-luciferase in WT vs Su(Fu)-null fibroblasts [PMID:22365972]; siRNA KD with LC3/Atg5 autophagosome assays for GAS [PMID:22452336]

    PMID:22365972 PMID:22452336

    Open questions at the time
    • Whether Su(Fu) interaction occurs at cilia or endosomes unclear
    • Mechanism of autophagosome recruitment undefined
    • GAS-targeting specificity mechanism unknown
  7. 2014 High

    Demonstration that Rab23 is required in the node for Nodal signal production—independent of Hh—revealed a Hedgehog-independent developmental function in left-right axis determination.

    Evidence Mouse/zebrafish double-mutant analysis, Nodal protein and cDNA rescue in embryos

    PMID:24780629

    Open questions at the time
    • Trafficking cargo for Nodal signaling not identified
    • Whether this involves cilia in the node not resolved
  8. 2015 High

    Rab23 was shown to form a complex with Kif17 and importin-β2 and to be required for ciliary targeting of Kif17 and dopamine D1 receptors via IFT-B, establishing a general receptor ciliary delivery pathway.

    Evidence Co-IP and affinity binding of Rab23–Kif17–importin-β2 [PMID:26136363]; siRNA depletion and Rab23 chimera mis-targeting for D1R ciliary access [PMID:26182404]

    PMID:26136363 PMID:26182404

    Open questions at the time
    • Full repertoire of Rab23-dependent ciliary cargoes unknown
    • Whether Rab23 enters cilia with cargo not resolved
  9. 2018 Medium

    Rab23 was found to regulate cortical neuron radial migration through PDGFRα–ERK1/2–N-cadherin signaling, extending its functions beyond Hh-dependent contexts into neuronal cell biology.

    Evidence In utero electroporation KD/CKO with rescue, Western blot, pharmacological ERK inhibition in mouse cortex

    PMID:29420702

    Open questions at the time
    • Whether this involves ciliary or endosomal Rab23 pools not distinguished
    • Direct binding partners in this pathway not identified
  10. 2019 High

    Identification of the Inturned–Fuzzy complex as a Rab23-specific GEF resolved how Rab23 GTP loading is regulated and linked planar cell polarity effector proteins to Rab23 activation at the basal body.

    Evidence Biochemical GEF assay, Drosophila loss-of-function genetics, siRNA in mammalian cells, longin domain analysis

    PMID:31564489

    Open questions at the time
    • No GAP for Rab23 identified
    • Structural basis of GEF specificity unresolved
  11. 2020 High

    The Carpenter syndrome craniosynostosis mechanism was elucidated: RAB23 deficiency causes osteoprogenitor hyperproliferation via elevated FGF10–FGFR1–pERK1/2 and GLI1 signaling, rescuable by ERK inhibition.

    Evidence Rab23-deficient mouse, immunostaining, Western blot, pharmacological pERK1/2 rescue

    PMID:32662771

    Open questions at the time
    • Whether FGFR trafficking is directly Rab23-dependent not shown
    • Tissue-specific cilia dependence not yet tested
  12. 2021 High

    Conditional knockout in cerebellum revealed Rab23 has dual opposing roles: it represses basal Hh pathway activity but facilitates cilium-dependent Smo translocation upon extrinsic Shh stimulation, reconciling apparently conflicting observations.

    Evidence Nestin-Cre CKO mouse, Gli reporter, SAG stimulation, Smo ciliary localization assay

    PMID:34210780

    Open questions at the time
    • How Rab23 simultaneously represses basal and promotes stimulated Hh at the molecular level is mechanistically unresolved
  13. 2024 High

    Crystal structures of GDP-bound and GTP-analog-bound human RAB23, plus the Carpenter-associated Y79del mutant, provided the first atomic-level view, showing that Y79del distorts switch II to disrupt effector binding.

    Evidence X-ray crystallography, in vitro biochemical and mutant functional assays

    PMID:39615683

    Open questions at the time
    • No co-crystal with Su(Fu) or any effector
    • Structural basis of GEF (Inturned–Fuzzy) recognition unknown
  14. 2025 High

    Multiple studies converged to show that RAB23 loss causes context-dependent (cell-type-specific) cilia defects confirming Carpenter syndrome as a ciliopathy, that RAB23 participates in clathrin-coated vesicle formation at the plasma membrane via AP-2/PICALM/endophilin A2, and that EP4 is an additional Rab23-dependent ciliary cargo.

    Evidence CKO mouse/iPSC-neurons/zebrafish cilia analysis [PMID:40825043]; co-IP of RAB23–AP-2–PICALM–endophilin A2 with transferrin uptake assays [PMID:40261407]; siRNA screen and co-IP for EP4 ciliary trafficking [PMID:41372612]

    PMID:40261407 PMID:40825043 PMID:41372612

    Open questions at the time
    • How Rab23 coordinates clathrin-mediated endocytosis with ciliary trafficking is unknown
    • Complete set of Rab23-dependent ciliary cargoes undefined
    • Whether clathrin role is GTP- or GDP-state-dependent not established

Open questions

Synthesis pass · forward-looking unresolved questions
  • Major open questions include: the identity of the Rab23 GAP, the structural basis of Rab23 interaction with Su(Fu) and the Inturned–Fuzzy GEF, the molecular logic determining cell-type-specific cilia dependence on Rab23, and how Rab23 mechanistically integrates its endosomal, plasma membrane, and ciliary trafficking functions.
  • No Rab23 GAP identified
  • No effector co-structure available
  • Cell-type specificity mechanism uncharacterized

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0098772 molecular function regulator activity 4 GO:0003924 GTPase activity 3
Localization
GO:0005886 plasma membrane 3 GO:0005929 cilium 3 GO:0031410 cytoplasmic vesicle 2 GO:0005768 endosome 1
Pathway
R-HSA-162582 Signal Transduction 6 R-HSA-1266738 Developmental Biology 4 R-HSA-5653656 Vesicle-mediated transport 4 R-HSA-1643685 Disease 2 R-HSA-9612973 Autophagy 1
Partners
AP2B1FUZINTUKIF17KPNB2PICALMSH3GL1SUFU
Complex memberships
AP-2/PICALM/endophilin A2/Rab23 clathrin vesicle complexIFT-B/KIF17/Rab23 ciliary transport complex

Evidence

Reading pass · 26 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2001 Rab23 is an essential negative regulator of the Sonic hedgehog (Shh) signaling pathway, acting downstream of Shh; loss of Rab23 in the open brain (opb) mouse mutant rescues ventral cell types absent in Shh mutants, placing Rab23 genetically downstream of Shh in neural tube patterning. Genetic epistasis (Shh opb double mutants), map-based cloning of the opb locus Nature High 11449277
2003 Rab23 localizes predominantly to the plasma membrane and early endocytic vesicles (colocalizing with Rab5Q79L and internalized transferrin); the constitutively active Q68L mutant shares this distribution while the dominant-negative S23N mutant is cytosolic. Patched colocalizes with intracellular Rab23-GFP vesicles but Smoothened does not, and neither Patched nor Smoothened distribution is altered by Rab23 expression. Live-cell fluorescence microscopy, immunoelectron microscopy, co-expression with GFP-tagged Rab23 mutants, co-localization with endocytic markers Traffic High 14617350
2005 Rab23 acts upstream of Gli transcription factors and downstream of Smoothened in the Shh pathway; double mutant analysis shows the primary target of Rab23 is Gli2 activator function, with additive effects with Gli3 repressor; Rab23 also promotes Gli3 repressor production. Rab23 does not work through Patched or Smoothened. Genetic epistasis (Rab23/Gli2, Rab23/Gli3, Rab23/Smo double mutants in mouse), Gli3 protein analysis Developmental Biology High 16364285
2007 RAB23 mutations (truncating and one missense) cause Carpenter syndrome with autosomal recessive inheritance; RAB23 functions as a negative regulator of Hedgehog signaling and is required for cranial suture development, implicating HH signaling in craniosynostosis. Homozygosity mapping, direct sequencing of RAB23 in 15 families, identification of loss-of-function mutations American Journal of Human Genetics High 17503333
2008 Elevated Rab23 expression inhibits chondrogenic differentiation of ATDC5 cells, as shown by retroviral insertion into the Rab23 promoter causing differentiation failure; conversely, stable siRNA knockdown of Rab23 also inhibits differentiation and reduces Sox9 and Gli1 expression, indicating Rab23 regulates chondrogenesis via the Gli1-Sox9 axis. Retroviral insertion mutagenesis, stable siRNA knockdown, overexpression, RT-PCR for Sox9/Gli1 Journal of Biological Chemistry Medium 18218620
2010 Depletion of Rab23 or expression of dominant-negative Rab23 specifically decreases steady-state Smoothened levels in the primary cilium without affecting EB1 or the apical protein Kim1, demonstrating a role for Rab23 in regulating Smoothened protein turnover within the cilium. FRAP (fluorescence recovery after photobleaching) in MDCK cilia, dominant-negative Rab23 expression, siRNA knockdown Journal of Cell Science High 20375059
2010 Drosophila Rab23 associates with the planar cell polarity protein Prickle and is required for hexagonal packing of wing cells and restriction of prehair initiation; absence of Rab23 leads to increased subapical actin accumulation; Rab23 acts as a dominant enhancer of core polarity mutations and is sensitive to planar polarity effector gene dosage. Genetic screen, loss-of-function Drosophila mutants, co-association assay with Prickle, actin staining, genetic interaction with PCP effector genes Genetics Medium 20124028
2012 Rab23 directly associates with Su(Fu) (Suppressor of Fused) and inhibits Gli1 transcriptional activity in a Su(Fu)-dependent manner; Rab23 suppresses Gli1 nuclear localization in wild-type but not Su(Fu)-null fibroblasts; GTPase activity of Rab23 is required, as the dominant-negative form cannot suppress Gli1 activity. Co-immunoprecipitation, confocal microscopy for colocalization, Gli1-luciferase reporter assay in WT vs. Su(Fu) null fibroblasts, GTPase activity assay, dominant-negative mutant analysis Cellular Signalling High 22365972
2012 Rab23 is recruited to GAS-capturing forming autophagosomes (GcAVs) during Group A Streptococcus infection; knockdown of Rab23 decreases both LC3- and Atg5-positive GAS-associated structures and causes accumulation of LC3-positive structures not associated with intracellular GAS, indicating Rab23 is required for autophagosomal vacuole formation targeting GAS but is dispensable for starvation-induced autophagy. siRNA knockdown, fluorescence microscopy (LC3/Atg5 colocalization), GcAV formation assay Cellular Microbiology Medium 22452336
2014 Rab23 plays a separate role in Nodal signaling and left-right patterning independently of the Hedgehog pathway; Rab23 is required in the node/Kupffer's vesicle for production of functional Nodal signals (not the response to them), as demonstrated by microinjection of Nodal protein and Nodal cDNA in embryos. Gain- and loss-of-function approaches in both mouse and zebrafish confirm this role. Mouse double mutant analysis, Nodal protein microinjection, Nodal cDNA transfection in embryo, zebrafish gain/loss-of-function Developmental Biology High 24780629
2015 Rab23 is required for ciliary targeting of the kinesin-2 motor Kif17; wild-type and constitutively active Rab23 Q68L enrich at the primary cilium; Rab23 exists in a complex with Kif17 and importin β2 (as shown by co-immunoprecipitation and affinity-binding); Rab23 depletion disrupts ciliary localization of Kif17 but Rab23 and Ran have distinct roles in Kif17 ciliary import. Immunofluorescence, co-immunoprecipitation, affinity-binding studies, Rab23 siRNA depletion, GFP-tagged Rab23 localization Journal of Cell Science High 26136363
2015 D1-type dopamine receptors are delivered to the ciliary membrane by a mechanism requiring the receptor cytoplasmic tail, IFT-B complex, KIF17, and Rab23; depletion of Rab23 prevents dopamine receptor ciliary access; fusion of Rab23 to a non-ciliary receptor drives its nucleotide-dependent mis-localization to the ciliary membrane. siRNA depletion, GFP-receptor chimera mis-targeting, live-cell ciliary imaging, IFT-B perturbation eLife High 26182404
2016 Rab23 promotes squamous cell carcinoma cell migration and invasion in a GTP-dependent manner; Rab23 co-localizes and co-precipitates with integrin β1 and Tiam1 in a GTP-dependent manner at the cell membrane; integrin β1 siRNA disrupts the Rab23-Tiam1 interaction and attenuates Rab23-promoted migration; Rac1 inhibition or silencing attenuates Rab23-promoted invasion, placing Rab23 upstream of integrin β1/Tiam1/Rac1. Co-immunoprecipitation, siRNA, Transwell invasion assay, Rac1 activity assay, stable overexpression of WT and Q68L Rab23 Oncotarget Medium 26716504
2018 Rab23 regulates radial migration of cortical projection neurons via N-cadherin; Rab23-KD neurons show reduced N-cadherin expression and impaired migration; Rab23 silencing impedes ERK1/2 activation via perturbed PDGFRα signaling; pharmacological ERK1/2 inhibition also reduces N-cadherin; restoration of Rab23 or N-cadherin reverses migration defects. In utero electroporation knockdown, conditional knockout, Western blot (ERK1/2, N-cadherin, PDGFRα), pharmacological inhibition, rescue experiments Cerebral Cortex Medium 29420702
2019 Inturned and Fuzzy, planar cell polarity effector proteins containing multiple longin domains characteristic of Mon1-Ccz1 family Rab7 GEFs, form a specific Rab23 GEF complex; in flies, loss of Rab23 causes planar-polarized trichome defects consistent with this relationship; in cultured cells, Inturned and Fuzzy localize to the basal body/proximal cilia and their depletion arrests ciliogenesis after ciliary vesicle docking but before axoneme elongation. Biochemical GEF activity assay, Drosophila genetics (loss-of-function), siRNA in human/mouse cells, immunofluorescence localization, longin domain sequence analysis Current Biology High 31564489
2019 GTP-bound Rab23 accumulates at the spindle during mouse oocyte meiosis and promotes migration of Kif17 to spindle poles; depletion of Rab23 or Kif17 causes polar body extrusion failure and perturbs spindle formation, chromosome alignment, and tubulin acetylation; Kif17 regulates tubulin acetylation by associating with αTAT and Sirt2; Kif17 tail domain associates with RhoA-ROCK-LIMK-cofilin pathway components to modulate actin assembly for spindle migration. siRNA depletion, immunofluorescence (spindle/actin), co-immunoprecipitation (Kif17-αTAT/Sirt2/RhoA-ROCK-LIMK-cofilin), polar body extrusion assay Development Medium 30696709
2019 Rab23 is involved in apical trafficking of influenza hemagglutinin (HA) and neuraminidase (NA); HA associates with Rab23 in lipid raft fractions (co-immunoprecipitation); Rab23 dominant-negative expression impairs cell surface expression of HA; Rab23-positive vesicles transport HA/NA in the apical cytoplasm, downstream of Rab17. Co-immunoprecipitation, live-cell imaging, dominant-negative expression, cholesterol depletion, immunofluorescence colocalization Frontiers in Microbiology Medium 31456775
2020 RAB23 deficiency causes premature cranial suture fusion through aberrant osteoprogenitor proliferation driven by elevated FGF10-FGFR1/pERK1/2 signaling; RAB23 acts as an upstream negative regulator of both FGFR and canonical Hh-GLI1 signaling, and also non-canonically regulates GLI1 through pERK1/2; inhibition of pERK1/2 normalizes osteoprogenitor proliferation and prevents craniosynostosis. Rab23-deficient mouse model, immunostaining, Western blot (pERK1/2, FGFR1, RUNX2, GLI1), pharmacological pERK1/2 inhibition rescue eLife High 32662771
2021 Conditional knockout of Rab23 in mouse brain causes mis-patterning of cerebellar folia and elevated granule cell precursor (GCP) proliferation; Rab23-depleted GCPs show upregulated basal Shh pathway activity but abnormal ciliogenesis; they are desensitized to extrinsic Shh and Smo agonist (SAG) stimulation with attenuated Smo ciliary localization in response to SAG, revealing dual functions: Rab23 represses basal Hh signaling but facilitates cilium-dependent extrinsic Shh activation. Nestin-Cre conditional KO mouse, immunofluorescence, Gli luciferase reporter, SAG treatment, Smo ciliary localization assay Journal of Neuroscience High 34210780
2024 Crystal structures of human Rab23 in complex with GDP and with the non-hydrolysable GTP analog GMPPNP were determined, along with the structure of the Carpenter syndrome Y79del clinical mutant; the Y79del mutant shows structural distortions in the switch II region that disrupt binding to interacting partners, causing loss-of-function and Carpenter syndrome pathogenesis. X-ray crystallography (high-resolution crystal structures of GDP- and GMPPNP-bound forms), in vitro biochemical assays, functional analyses of mutants Journal of Biological Chemistry High 39615683
2007 Rab23 is phosphorylated in mouse brain specifically in response to cytidine 3′,5′-cyclic monophosphate (cCMP) but not cAMP or cGMP, identifying Rab23 as the first protein reported to be selectively phosphorylated in response to cCMP. IMAC phosphoprotein enrichment from mouse brain, MALDI-ToF MS and LC/ESI-MS/MS identification of tryptic phosphopeptides Rapid Communications in Mass Spectrometry Low 17639578
2025 RAB23 interacts with β-adaptin (AP2β1) subunit of the AP-2 clathrin adaptor complex, with clathrin assembly protein PICALM, with vesicle curvature protein endophilin A2, and with cortactin; RAB23 deficiency reduces AP2β1-clathrin interaction and impairs clathrin-dependent endocytosis (transferrin uptake); BMP-stimulated vesicle formation and signal transduction are aberrant in RAB23-deficient cells, indicating RAB23 functions in clathrin-coated nascent vesicle formation at the plasma membrane. Co-immunoprecipitation (RAB23/AP2β1/PICALM/endophilin A2/cortactin), time-lapse live-cell imaging of transferrin uptake, RAB23 KD with rescue, microarray-driven hypergeometric test, BMP signaling assay Cellular and Molecular Life Sciences Medium 40261407
2025 RAB23 (in its GDP-bound state) localizes to the basal body just below the transition zone and acts as a RAB18-specific guanine nucleotide exchange factor (GEF); RAB23-GDP activates RAB18-GDP, which then recruits the BBSome as an effector to cross the transition zone for ciliary entry; RAB23-GDP subsequently enters cilia as a BBSome cargo, establishing a RAB23-RAB18 module that mediates inward BBSome transition zone diffusion for proper ciliary signaling. Chlamydomonas model, GEF activity assay, localization studies, BBSome interaction assays bioRxiv (preprint)preprint Low bio_10.1101_2025.02.20.639385
2025 RAB23 loss-of-function causes context-dependent (cell-type-specific) primary cilia defects in vivo; Rab23-CKO mouse mutants, CS patient iPSC-derived neurons, and zebrafish morphants all show perturbed cilia formation selectively in certain cell types (chondrocytes, neocortical neurons) but not others (epithelial cells, cerebellar granule cells); Rab23-KO neural progenitors are desensitized to cilium-dependent Hedgehog pathway activation, confirming Carpenter syndrome as a ciliopathy. Conditional knockout mouse (Rab23-CKO), patient iPSC differentiation, zebrafish morpholino knockdown, immunofluorescence of cilia in multiple cell types, Hedgehog pathway activity assay PLoS Genetics High 40825043
2025 Rab23 and IFT43 are identified as crucial regulators of prostaglandin E receptor 4 (EP4) ciliary trafficking; EP4 physically interacts with IFT43 and Rab23 through its IC3 loop and C-terminal region; high-content siRNA screening and zebrafish/mammalian validation confirm that Rab23 (and IFT43) are required for EP4 delivery to primary cilia. High-content siRNA screen, co-immunoprecipitation (EP4/IFT43/Rab23), zebrafish embryo localization, mammalian cell ciliary trafficking assay, CRISPR base editing of EP4 LPG motif Communications Biology Medium 41372612
2022 Rab23 co-localizes with mature melanosomes (TRP-1-positive) and its downregulation by siRNA reduces melanin synthesis, tyrosinase activity, and inhibits UVB-induced melanogenesis via decreased PKA/CREB/MITF pathway activity; Rab23 knockdown also causes abnormal melanosome accumulation around the nucleus, implicating Rab23 in melanosome transport. siRNA knockdown, melanin quantification, tyrosinase activity assay, immunofluorescence co-localization (Rab23/TRP-1), Western blot (PKA/CREB/MITF pathway) Experimental Dermatology Low 35514241

Source papers

Stage 0 corpus · 80 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2001 Rab23 is an essential negative regulator of the mouse Sonic hedgehog signalling pathway. Nature 303 11449277
2007 RAB23 mutations in Carpenter syndrome imply an unexpected role for hedgehog signaling in cranial-suture development and obesity. American journal of human genetics 179 17503333
2005 Mouse Rab23 regulates hedgehog signaling from smoothened to Gli proteins. Developmental biology 120 16364285
2003 Rab23, a negative regulator of hedgehog signaling, localizes to the plasma membrane and the endocytic pathway. Traffic (Copenhagen, Denmark) 105 14617350
2008 Integrative genomics identifies RAB23 as an invasion mediator gene in diffuse-type gastric cancer. Cancer research 95 18559507
2010 Differential role of Rab proteins in ciliary trafficking: Rab23 regulates smoothened levels. Journal of cell science 86 20375059
2012 The small GTPases Rab9A and Rab23 function at distinct steps in autophagy during Group A Streptococcus infection. Cellular microbiology 75 22452336
2015 Dopamine receptors reveal an essential role of IFT-B, KIF17, and Rab23 in delivering specific receptors to primary cilia. eLife 70 26182404
2007 Rab23 is a potential biological target for treating hepatocellular carcinoma. World journal of gastroenterology 49 17373734
2018 miR-338-3p targets RAB23 and suppresses tumorigenicity of prostate cancer cells. American journal of cancer research 45 30662812
2010 RAB23 mutation in a large family from Comoros Islands with Carpenter syndrome. American journal of medical genetics. Part A 45 20358613
2019 Planar Cell Polarity Effector Proteins Inturned and Fuzzy Form a Rab23 GEF Complex. Current biology : CB 43 31564489
2017 MiR-429 regulates the metastasis and EMT of HCC cells through targeting RAB23. Archives of biochemistry and biophysics 42 29191386
1994 Isolation of a mouse cDNA encoding Rab23, a small novel GTPase expressed predominantly in the brain. Gene 40 8125302
2019 Circular RNA MYLK promotes hepatocellular carcinoma progression by increasing Rab23 expression by sponging miR-362-3p. Cancer cell international 39 31413665
2016 MicroRNA-665 suppressed the invasion and metastasis of osteosarcoma by directly inhibiting RAB23. American journal of translational research 39 27904698
2014 The microRNA-367 inhibits the invasion and metastasis of gastric cancer by directly repressing Rab23. Genetic testing and molecular biomarkers 39 25489984
2006 Open brain gene product Rab23: expression pattern in the adult mouse brain and functional characterization. Journal of neuroscience research 39 16463280
2015 A role for Rab23 in the trafficking of Kif17 to the primary cilium. Journal of cell science 38 26136363
2015 Rab23 is overexpressed in human bladder cancer and promotes cancer cell proliferation and invasion. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 37 26715272
2012 Rab23 negatively regulates Gli1 transcriptional factor in a Su(Fu)-dependent manner. Cellular signalling 35 22365972
2006 Rab23: what exactly does it traffic? Traffic (Copenhagen, Denmark) 35 16683919
2019 Rab23/Kif17 regulate meiotic progression in oocytes by modulating tubulin acetylation and actin dynamics. Development (Cambridge, England) 34 30696709
2011 Carpenter syndrome: extended RAB23 mutation spectrum and analysis of nonsense-mediated mRNA decay. Human mutation 33 21412941
2017 Upregulation of miR-802 suppresses gastric cancer oncogenicity via targeting RAB23 expression. European review for medical and pharmacological sciences 32 29028094
2014 Rab23 regulates Nodal signaling in vertebrate left-right patterning independently of the Hedgehog pathway. Developmental biology 30 24780629
2016 Rab23 promotes squamous cell carcinoma cell migration and invasion via integrin β1/Rac1 pathway. Oncotarget 29 26716504
2015 Effect of Rab23 on the proliferation and apoptosis in breast cancer. Oncology reports 29 26238143
2016 MicroRNA-16 Alleviates Inflammatory Pain by Targeting Ras-Related Protein 23 (RAB23) and Inhibiting p38 MAPK Activation. Medical science monitor : international medical journal of experimental and clinical research 27 27770129
2010 Drosophila Rab23 is involved in the regulation of the number and planar polarization of the adult cuticular hairs. Genetics 24 20124028
2018 Rab23 promotes the cisplatin resistance of ovarian cancer via the Shh-Gli-ABCG2 signaling pathway. Oncology letters 23 29552151
2016 Rab23 is overexpressed in human astrocytoma and promotes cell migration and invasion through regulation of Rac1. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 21 26897750
2014 Prenatal findings in carpenter syndrome and a novel mutation in RAB23. American journal of medical genetics. Part A 21 25168863
2008 Rab23 regulates differentiation of ATDC5 chondroprogenitor cells. The Journal of biological chemistry 21 18218620
2005 Characterization of Rab23, a negative regulator of sonic hedgehog signaling. Methods in enzymology 21 16473637
2019 lncRNA OSER1-AS1 acts as a ceRNA to promote tumorigenesis in hepatocellular carcinoma by regulating miR-372-3p/Rab23 axis. Biochemical and biophysical research communications 20 31635804
2016 RAB23, regulated by miR-92b, promotes the progression of esophageal squamous cell carcinoma. Gene 20 27659550
2020 RAB23 coordinates early osteogenesis by repressing FGF10-pERK1/2 and GLI1. eLife 19 32662771
2020 CircHIPK3 Promotes Thyroid Cancer Tumorigenesis and Invasion through the Mirna-338-3p/RAB23 Axis. Medical principles and practice : international journal of the Kuwait University, Health Science Centre 18 33105143
2018 Rab23 Promotes Hepatocellular Carcinoma Cell Migration Via Rac1/TGF-β Signaling. Pathology oncology research : POR 18 30191377
2017 Downregulation of Rab23 in Prostate Cancer Inhibits Tumor Growth In Vitro and In Vivo. Oncology research 18 28277196
2019 Apical Trafficking Pathways of Influenza A Virus HA and NA via Rab17- and Rab23-Positive Compartments. Frontiers in microbiology 17 31456775
2018 Association of genetic variants in RAB23 and ANXA11 with uveitis in sarcoidosis. Molecular vision 17 29416296
2018 Rab23 Regulates Radial Migration of Projection Neurons via N-cadherin. Cerebral cortex (New York, N.Y. : 1991) 17 29420702
2016 Rab23 activities and human cancer-emerging connections and mechanisms. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 17 27449041
2007 Mass spectrometric identification of Rab23 phosphorylation as a response to challenge by cytidine 3',5'-cyclic monophosphate in mouse brain. Rapid communications in mass spectrometry : RCM 17 17639578
2020 MicroRNA-429 inhibits the proliferation and migration of esophageal squamous cell carcinoma cells by targeting RAB23 through the NF-κB pathway. European review for medical and pharmacological sciences 16 32096149
2018 Rab23 and developmental disorders. Reviews in the neurosciences 16 29727300
2012 Sublocalization of Rab23, a mediator of Sonic hedgehog signaling pathway, in hepatocellular carcinoma cell lines. Molecular medicine reports 16 23007279
2012 A Novel Aberrant Splice Site Mutation in RAB23 Leads to an Eight Nucleotide Deletion in the mRNA and Is Responsible for Carpenter Syndrome in a Consanguineous Emirati Family. Molecular syndromology 16 23599695
2003 Molecular cloning and characterization of human RAB23, a member of the group of Rab GTPases. International journal of molecular medicine 16 14612978
2018 MicroRNA-16 suppressed the invasion and migration of osteosarcoma by directly inhibiting RAB23. European review for medical and pharmacological sciences 15 29771408
2017 Rab23's genetic structure, function and related diseases: a review. Bioscience reports 15 28104793
2015 Inactivation of Rab23 inhibits the invasion and motility of pancreatic duct adenocarcinoma. Genetics and molecular research : GMR 14 25867419
2011 Rab23 is a flagellar protein in Trypanosoma brucei. BMC research notes 14 21676215
2021 Multifaceted Functions of Rab23 on Primary Cilium-Mediated and Hedgehog Signaling-Mediated Cerebellar Granule Cell Proliferation. The Journal of neuroscience : the official journal of the Society for Neuroscience 11 34210780
2023 Biomarker of Pulmonary Inflammatory Response in LUAD: miR-584-5p Targets RAB23 to Suppress Inflammation Induced by LPS in A549 Cells. Protein and peptide letters 10 38093594
2019 Downregulation of Rab23 inhibits proliferation, invasion, and metastasis of human ovarian cancer. The international journal of biochemistry & cell biology 9 31550546
2011 Rab23 plays a role in the pathophysiology of mesangial cells--a proteomic analysis. Proteomics 9 21268268
2007 Rab23 GTPase is expressed asymmetrically in Hensen's node and plays a role in the dorsoventral patterning of the chick neural tube. Developmental dynamics : an official publication of the American Association of Anatomists 9 17937392
2005 Expression of the Hedgehog antagonists Rab23 and Slimb/betaTrCP during mouse tooth development. Archives of oral biology 9 15721142
2021 miR‑367‑3p downregulates Rab23 expression and inhibits Hedgehog signaling resulting in the inhibition of the proliferation, migration, and invasion of prostate cancer cells. Oncology reports 8 34278506
2023 MicroRNA-367-3p directly targets RAB23 and inhibits proliferation, migration and invasion of bladder cancer cells and increases cisplatin sensitivity. Journal of cancer research and clinical oncology 7 37935937
2018 miR-384 suppressed renal cell carcinoma cell proliferation and migration through targeting RAB23. Journal of cellular biochemistry 6 30390327
2023 Downregulation of Rab23 inhibits hepatocellular carcinoma by repressing SHH signaling pathway. Cancer reports (Hoboken, N.J.) 4 37884351
2020 miR-597-3p inhibits invasion and migration of thyroid carcinoma SW579 cells by targeting RAB23. Endokrynologia Polska 4 32856288
2022 Effect of Licochalcone-A Combined with Rab23 Gene on Proliferation of Glioma U251 Cells. Evidence-based complementary and alternative medicine : eCAM 3 35497928
2019 Integrated analysis and knockdown of RAB23 indicate the role of RAB23 in gastric adenocarcinoma. Annals of translational medicine 3 32042761
2024 Cap-Specific m6Am Methyltransferase PCIF1/CAPAM Regulates mRNA Stability of RAB23 and CNOT6 through the m6A Methyltransferase Activity. Cells 2 39451207
2024 Structural basis for Rab23 activation and a loss-of-function mutation in Carpenter syndrome. The Journal of biological chemistry 2 39615683
2022 Silencing of Rab23 by siRNA inhibits ultraviolet B-induced melanogenesis via downregulation of PKA/CREB/MITF. Experimental dermatology 2 35514241
2015 [Rab23 enhances invasion of Sa3 cutaneous squamous cell carcinoma cells via up-regulating the expression of Rac1]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 2 26648292
2013 [Role of Rab23 in invasion and migration of human breast cancer Bcap-37 cells]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 2 23948406
2025 RAB23 facilitates clathrin-coated nascent vesicle formation at the plasma membrane and modulates cell signaling. Cellular and molecular life sciences : CMLS 1 40261407
2025 RAB23 loss-of-function mutation causes context-dependent ciliopathy in Carpenter syndrome. PLoS genetics 1 40825043
2023 RAB23 regulates musculoskeletal development and patterning. Frontiers in cell and developmental biology 1 36910145
2017 Molecular Analysis of Gli3, Ihh, Rab23, and Jag1 in a Rabbit Model of Craniosynostosis: Likely Exclusion as the Loci of Origin. The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association 1 29437519
2025 Rab23 GTPase and IFT43 regulate the trafficking of prostaglandin E receptor 4 to primary cilia. Communications biology 0 41372612
2024 The inhibition roles of RAB23 gene in granulosa cell proliferation and progesterone synthesis of hen ovarian prehierarchical follicles. British poultry science 0 39036858
2019 Rab23 contributes to the progression of colorectal cancer via protein kinase B and extracellular signal-regulated kinase signaling pathways. Oncology letters 0 31423247