Affinage

FUZ

Protein fuzzy homolog · UniProt Q9BT04

Length
418 aa
Mass
45.7 kDa
Annotated
2026-04-28
100 papers in source corpus 12 papers cited in narrative 12 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

FUZ is a planar cell polarity effector and CPLANE complex component that functions as a critical regulator of ciliogenesis by directing membrane trafficking of cargo to basal bodies and selectively promoting retrograde intraflagellar transport without affecting anterograde transport (PMID:19767740, PMID:22778277). Through its role in primary cilia formation, FUZ controls Sonic Hedgehog signal transduction by regulating Gli processing and the ciliary localization of GPR161, with which it physically interacts and is genetically epistatic (PMID:23806618, PMID:39369306). Loss of FUZ in mice disrupts Hedgehog-dependent patterning across multiple tissues—including neural tube, craniofacial structures, skin, and pituitary—while simultaneously derepressing canonical Wnt/β-catenin signaling through a negative feedback loop in which β-catenin/TCF directly drives Fuz transcription (PMID:21935430, PMID:20962855, PMID:37794731, PMID:38501709). FUZ mutations in humans cause ciliopathy phenotypes including skeletal dysplasia and Hirschsprung disease, attributed to impaired Hedgehog signaling and neural crest cell migration (PMID:41952398).

Mechanistic history

Synthesis pass · year-by-year structured walk · 8 steps
  1. 2009 High

    Establishing that FUZ is a membrane trafficking effector required for cargo delivery to basal bodies and cilia tips — and for exocytosis — resolved its cellular function as a vesicular transport regulator rather than a polarity signal transducer per se.

    Evidence In vivo mucociliary epithelium imaging, co-IP/interaction studies in Xenopus and mouse identifying a Rab-related GTPase partner

    PMID:19767740

    Open questions at the time
    • Identity of specific vesicular cargo delivered to basal bodies not determined
    • How FUZ interfaces with Rab GTPase machinery at a structural level unknown
    • Whether FUZ trafficking role is cilia-specific or broadly used in non-ciliated secretory cells not resolved
  2. 2010 Medium

    Demonstrating that FUZ loss abolishes primary cilia formation and Hedgehog signaling in skin cells in a cell-autonomous manner linked the trafficking defect to a specific developmental signaling output.

    Evidence Fuz knockout mouse with skin graft and reconstitution assays, Hedgehog pathway analysis

    PMID:20962855

    Open questions at the time
    • Molecular step at which Hedgehog signaling fails (ligand reception, transduction, Gli processing) not defined
    • Single lab study without independent replication
  3. 2011 Medium

    Showing that FUZ loss simultaneously reduces Hedgehog and elevates Wnt/β-catenin signaling — and that β-catenin/TCF directly binds the Fuz promoter — established FUZ as a node integrating and feeding back on two major developmental pathways.

    Evidence Fuz knockout mouse with signaling pathway analysis and chromatin immunoprecipitation

    PMID:21935430

    Open questions at the time
    • Whether Wnt upregulation is a direct consequence of cilia loss or a parallel FUZ function not distinguished
    • Functional significance of the negative feedback loop for pathway homeostasis not tested in vivo
  4. 2012 High

    Dissecting IFT dynamics revealed that FUZ selectively controls retrograde but not anterograde intraflagellar transport, pinpointing the mechanistic step at which FUZ acts within the cilium.

    Evidence Novel in vivo IFT dynamics imaging platform in Xenopus with directional IFT readouts upon Fuz loss-of-function

    PMID:22778277

    Open questions at the time
    • How FUZ distinguishes retrograde from anterograde IFT complexes at a molecular level unknown
    • Whether retrograde IFT defect fully accounts for the cargo delivery phenotype not established
  5. 2013 High

    Genetic epistasis showing that reducing Fgf8 rescues Fuz-mutant craniofacial defects placed dysregulated Gli processing → excess Fgf8 as the pathogenic mechanism, generalizable across ciliopathy models (Ofd1).

    Evidence Fuz mutant and Fuz/Fgf8 double-mutant rescue in mouse, comparison with Ofd1 mutant

    PMID:23806618

    Open questions at the time
    • Whether the Gli processing defect is due to retrograde IFT failure specifically was not tested
    • Applicability of the Gli-Fgf8 axis beyond craniofacial tissues not assessed
  6. 2018 Medium

    Identification of a non-ciliary role: FUZ overexpression triggers neuronal apoptosis via dishevelled/Rac1/MEKK1/JNK/caspase signaling, with YY1 transcriptional repression of FUZ lost upon polyQ aggregate sequestration — linking FUZ to neurodegeneration.

    Evidence Overexpression/knockdown in Drosophila neurodegeneration models, co-IP, ChIP, pathway inhibitor experiments

    PMID:30026307

    Open questions at the time
    • Relevance to mammalian neurodegeneration not demonstrated
    • Whether this pathway operates through cilia or is entirely cilia-independent unclear
    • Single lab, Drosophila-only system
  7. 2024 Medium

    Establishing that FUZ is genetically epistatic to GPR161 and physically interacts with it resolved how FUZ tunes Hedgehog signaling: by controlling ciliary localization of the negative Hedgehog regulator GPR161, potentially via β-arrestin 2.

    Evidence Double mutant genetic epistasis in mouse neural tube, co-immunoprecipitation, ciliary trafficking assays

    PMID:39369306

    Open questions at the time
    • Direct evidence for β-arrestin 2 involvement is indirect
    • Whether FUZ-GPR161 interaction is direct or mediated by CPLANE complex not resolved
    • Single lab study
  8. 2024 Medium

    FUZ ablation causing hindbrain hypoplasia with reduced ventral neuroepithelial stiffness expanded the phenotypic spectrum and implicated FUZ-dependent cilia in biomechanical tissue properties during neural tube development.

    Evidence Fuz knockout mouse with histology and atomic force microscopy-based stiffness measurements

    PMID:38501709

    Open questions at the time
    • Molecular mechanism linking cilia loss to tissue stiffness not identified
    • Whether stiffness change is a cause or consequence of patterning defects not determined

Open questions

Synthesis pass · forward-looking unresolved questions
  • The structural basis of FUZ's selective engagement with retrograde IFT machinery and the molecular details of how it recruits GPR161 to cilia remain unresolved; whether FUZ's non-ciliary roles (neuronal apoptosis, BNIP3 stabilization) represent physiologically important functions or overexpression artifacts also awaits clarification.
  • No high-resolution structural model of FUZ or the CPLANE complex
  • Retrograde IFT selectivity mechanism unknown at molecular level
  • Non-ciliary functions lack independent replication in mammalian systems

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060090 molecular adaptor activity 3
Localization
GO:0005929 cilium 3 GO:0005829 cytosol 2
Pathway
R-HSA-1266738 Developmental Biology 5 R-HSA-162582 Signal Transduction 3 R-HSA-1852241 Organelle biogenesis and maintenance 3 R-HSA-5653656 Vesicle-mediated transport 2
Partners
BNIP3CPLANE2FKBP8GPR161
Complex memberships
CPLANE complex

Evidence

Reading pass · 12 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2009 Fuz is essential for membrane trafficking of cargo to basal bodies and to the apical tips of cilia, and is required for exocytosis in secretory cells; a Rab-related small GTPase was identified as a Fuz interaction partner essential for ciliogenesis and secretion. In vivo mucociliary epithelium imaging, bioinformatics, co-immunoprecipitation/interaction studies in Xenopus and mouse Nature cell biology High 19767740
2012 Fuz is required for normal intraflagellar transport (IFT) dynamics in vertebrate cilia, specifically playing a role in retrograde IFT protein trafficking but not anterograde IFT, placing Fuz as a cytoplasmic effector that differentiates between retrograde and anterograde IFT complexes. In vivo IFT dynamics imaging platform in Xenopus, loss-of-function with specific IFT cargo readouts The Journal of cell biology High 22778277
2013 Fuz mutation causes dysregulated Gli processing leading to excessive craniofacial Fgf8 gene expression; genetic reduction of Fgf8 ameliorates maxillary phenotypes, placing Fuz upstream of Gli processing and Fgf8 in craniofacial development. Fuz mutant also phenocopied Ofd1 mutation, suggesting aberrant Fgf8 transcription is a common ciliopathy feature. Fuz mutant mouse analysis, genetic epistasis (Fuz/Fgf8 double mutant rescue), Ofd1 mutant comparison Developmental cell High 23806618
2011 Fuz regulates both Hedgehog (Hh) and Wnt/β-catenin signaling during craniofacial development; Hh signaling is down-regulated and canonical Wnt signaling is up-regulated in Fuz null mice. Cilia formation is decreased in mandible mesenchyme of Fuz null mice, suggesting cilia antagonize Wnt signaling in this tissue. β-catenin/TCF-binding directly regulates Fuz expression (chromatin IP), establishing a Fuz-dependent negative feedback loop. Fuz knockout mouse, signaling pathway analysis, chromatin immunoprecipitation (ChIP) PloS one Medium 21935430
2010 Disruption of Fuz in mice impairs formation of primary cilia in skin and blocks hedgehog signaling in the skin, severely blocking hair follicle development. Skin graft and reconstitution assays showed Fuz is required in both epidermal and dermal cells, and primary cilia formation is a cell-autonomous process not requiring epithelial-mesenchymal cross talk. Fuz knockout mouse, skin grafts and skin reconstitution assays, hedgehog pathway analysis The Journal of investigative dermatology Medium 20962855
2018 Overexpression of Fuz triggers neuronal apoptosis via the dishevelled/Rac1 GTPase/MEKK1/JNK/caspase signalling axis. The transcriptional regulator YY1 associates with the Fuz promoter and its hypermethylation represses Fuz; sequestration of YY1 by polyQ aggregates leads to Fuz transcriptional derepression and neuronal apoptosis. Overexpression and knockdown in Drosophila neurodegeneration models, co-immunoprecipitation, ChIP, pathway inhibitor experiments EMBO reports Medium 30026307
2023 FUZ (as part of the CPLANE complex) is essential for pituitary development; Fuz-/- mutants show Rathke's pouch failure to express LHX3 and hypoplasia. Mechanistically, reduced SHH pathway activation in Fuz-/- leads to deficient anterior pituitary fate specification, and abnormal FGF8 and BMP4 patterning in the ventral diencephalon further impairs pituitary development. Fuz-/- mouse histological analysis, SHH, FGF8, and BMP4 signaling assays Journal of anatomy Medium 37794731
2024 Fuz is genetically epistatic to Gpr161 in Sonic Hedgehog signaling regulation during mouse neural tube development. FUZ protein biochemically interacts with GPR161, and Fuz regulates Gpr161-mediated ciliary localization, a process that may utilize β-arrestin 2. Genetic epistasis (double mutant analysis), co-immunoprecipitation, ciliary trafficking assays Development (Cambridge, England) Medium 39369306
2024 Fuz ablation in mouse embryos results in hypoplastic hindbrain with abnormal rhombomeres, persistent reduction of ventral neuroepithelial stiffness in notochord-adjacent areas, and impaired cranial and paravertebral ganglia formation, demonstrating Fuz's role in neural tube development and neuronal differentiation. Fuz knockout mouse, histology, biomechanical stiffness measurements Developmental dynamics Medium 38501709
2018 FUZ was identified as a BNIP3-interacting protein; loss of FUZ results in decreased BNIP3 protein level without affecting BNIP3 mRNA, suggesting FUZ stabilizes BNIP3 protein. FUZ overexpression also activates Erk1/2 and STAT3 phosphorylation and promotes EMT in NSCLC cells. Co-immunoprecipitation, siRNA knockdown and overexpression in NSCLC cell lines, western blot, migration/invasion assays Life sciences Low 29421438
2025 Affinity-based LC-MS/MS proteomic profiling identified 159 proteins co-interacting with both FUZ and GPR161, 289 proteins exclusive to FUZ, and 617 exclusive to GPR161. FKBP8 was confirmed to biochemically interact with both FUZ and GPR161. GO analysis linked FUZ interactome to proteasomal catabolic processes, trafficking, cell cycle progression, mitochondrial membrane, RNA metabolism, and ER-Golgi transport. Affinity-based immunoprecipitation followed by LC-MS/MS (AP-MS), STRING network validation bioRxivpreprint Low 41000683
2026 In silico structural analysis of a novel FUZ missense variant predicted altered interactions between FUZ and CPLANE2 (RSG1), consistent with disruption of ciliogenesis. FUZ-related ciliopathy phenotypes include skeletal dysplasia, aorto-pulmonary window, and Hirschsprung disease, mechanistically attributed to impaired Sonic Hedgehog signaling via primary cilia dysfunction affecting neural crest cell migration. In silico 3D structural analysis, clinical genetics/patient phenotyping Clinical genetics Low 41952398

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2003 FY is an RNA 3' end-processing factor that interacts with FCA to control the Arabidopsis floral transition. Cell 313 12809608
2009 The planar cell polarity effector Fuz is essential for targeted membrane trafficking, ciliogenesis and mouse embryonic development. Nature cell biology 193 19767740
2017 Commentary on "Integrative clinical genomics of advanced prostate cancer". Robinson D, Van Allen EM, Wu YM, Schultz N, Lonigro RJ, Mosquera JM, Montgomery B, Taplin ME, Pritchard CC, Attard G, Beltran H, Abida W, Bradley RK, Vinson J, Cao X, Vats P, Kunju LP, Hussain M, Feng FY, Tomlins SA, Cooney KA, Smith DC, Brennan C, Siddiqui J, Mehra R, Chen Y, Rathkopf DE, Morris MJ, Solomon SB, Durack JC, Reuter VE, Gopalan A, Gao J, Loda M, Lis RT, Bowden M, Balk SP, Gaviola G, Sougnez C, Gupta M, Yu EY, Mostaghel EA, Cheng HH, Mulcahy H, True LD, Plymate SR, Dvinge H, Ferraldeschi R, Flohr P, Miranda S, Zafeiriou Z, Tunariu N, Mateo J, Perez-Lopez R, Demichelis F, Robinson BD, Schiffman M, Nanus DM, Tagawa ST, Sigaras A, Eng KW, Elemento O, Sboner A, Heath EI, Scher HI, Pienta KJ, Kantoff P, de Bono JS, Rubin MA, Nelson PS, Garraway LA, Sawyers CL, Chinnaiyan AM.Cell. 21 May 2015;161(5):1215-1228. Urologic oncology 157 28623072
1999 Emergence of FY*A(null) in a Plasmodium vivax-endemic region of Papua New Guinea. Proceedings of the National Academy of Sciences of the United States of America 149 10570183
1995 Mutations in the erythrocyte chemokine receptor (Duffy) gene: the molecular basis of the Fya/Fyb antigens and identification of a deletion in the Duffy gene of an apparently healthy individual with the Fy(a-b-) phenotype. British journal of haematology 118 7669660
2011 Fy(a)/Fy(b) antigen polymorphism in human erythrocyte Duffy antigen affects susceptibility to Plasmodium vivax malaria. Proceedings of the National Academy of Sciences of the United States of America 110 22123959
1998 Arg89Cys substitution results in very low membrane expression of the Duffy antigen/receptor for chemokines in Fy(x) individuals. Blood 94 9731074
2000 Significant admixture linkage disequilibrium across 30 cM around the FY locus in African Americans. American journal of human genetics 79 10712211
2013 Fuz mutant mice reveal shared mechanisms between ciliopathies and FGF-related syndromes. Developmental cell 78 23806618
1998 A clinically applicable method for determining the three major alleles at the Duffy (FY) blood group locus using polymerase chain reaction with allele-specific primers. Transfusion 74 9531948
1998 The Fy(x) phenotype is associated with a missense mutation in the Fy(b) allele predicting Arg89Cys in the Duffy glycoprotein. British journal of haematology 74 9886340
1988 A genetic linkage map of 27 loci from PND to FY on the short arm of human chromosome I. American journal of human genetics 69 2902785
1998 A novel mutation in the coding sequence of the FY*B allele of the Duffy chemokine receptor gene is associated with an altered erythrocyte phenotype. Blood 64 9746760
2005 An allelic series reveals essential roles for FY in plant development in addition to flowering-time control. Development (Cambridge, England) 62 16033802
2000 Differentiation of autologous ABO, RHD, RHCE, KEL, JK, and FY blood group genotypes by analysis of peripheral blood samples of patients who have recently received multiple transfusions. Transfusion 59 10960520
2011 Fuz regulates craniofacial development through tissue specific responses to signaling factors. PloS one 53 21935430
2012 Control of vertebrate intraflagellar transport by the planar cell polarity effector Fuz. The Journal of cell biology 52 22778277
2006 Additional targets of the Arabidopsis autonomous pathway members, FCA and FY. Journal of experimental botany 52 16940039
2008 Duffy (Fy), DARC, and neutropenia among women from the United States, Europe and the Caribbean. British journal of haematology 50 18710383
2001 Fy phenotype and gender determine plasma levels of monocyte chemotactic protein. Transfusion 49 11274594
1996 Characterization of the Duffy gene promoter: evidence for tissue-specific abolishment of expression in Fy(a-b-) of black individuals. Biochemical and biophysical research communications 49 8651934
2000 New genotypes in Fy(a-b-) individuals: nonsense mutations (Trp to stop) in the coding sequence of either FY A or FY B. British journal of haematology 46 10691880
2019 Transcriptome Analyses of FY Mutants Reveal Its Role in mRNA Alternative Polyadenylation. The Plant cell 43 31427469
2016 Bacterial cellulose synthesis mechanism of facultative anaerobe Enterobacter sp. FY-07. Scientific reports 43 26911736
2018 Production of bacterial cellulose hydrogels with tailored crystallinity from Enterobacter sp. FY-07 by the controlled expression of colanic acid synthetic genes. Carbohydrate polymers 39 30600040
2004 A novel FY allele in Brazilians. Vox sanguinis 38 15569072
2000 Differential expression of the duffy antigen receptor for chemokines according to RBC age and FY genotype. Transfusion 36 10960522
2012 Natural selection mediated association of the Duffy (FY) gene polymorphisms with Plasmodium vivax malaria in India. PloS one 33 23028857
2010 Fuz controls the morphogenesis and differentiation of hair follicles through the formation of primary cilia. The Journal of investigative dermatology 33 20962855
2009 Altered interactions within FY/AtCPSF complexes required for Arabidopsis FCA-mediated chromatin silencing. Proceedings of the National Academy of Sciences of the United States of America 33 19439664
2005 Antibody response to Plasmodium vivax antigens in Fy-negative individuals from the Colombian Pacific coast. The American journal of tropical medicine and hygiene 32 16291766
2023 Validation of a non-invasive prenatal test for fetal RhD, C, c, E, K and Fya antigens. Scientific reports 31 37550335
2012 The Arabidopsis mutant, fy-1, has an ABA-insensitive germination phenotype. Journal of experimental botany 30 22282534
2017 Targeting the Nuclear Cathepsin L CCAAT Displacement Protein/Cut Homeobox Transcription Factor-Epithelial Mesenchymal Transition Pathway in Prostate and Breast Cancer Cells with the Z-FY-CHO Inhibitor. Molecular and cellular biology 27 27956696
2020 Production of nisin-containing bacterial cellulose nanomaterials with antimicrobial properties through co-culturing Enterobacter sp. FY-07 and Lactococcus lactis N8. Carbohydrate polymers 26 33142662
1994 Confirmation of Duffy blood group antigen locus (FY) at 1q22-->q23 by fluorescence in situ hybridization. Cytogenetics and cell genetics 26 8187556
2010 FY polymorphisms and vivax malaria in inhabitants of Amazonas State, Brazil. Parasitology research 24 20162434
2018 Planar cell polarity gene Fuz triggers apoptosis in neurodegenerative disease models. EMBO reports 23 30026307
1997 Comparison of Fy(b) status as determined serologically and genetically. Transfusion medicine (Oxford, England) 22 9195700
2020 Microbial enhanced oil recovery through deep profile control using a conditional bacterial cellulose-producing strain derived from Enterobacter sp. FY-07. Microbial cell factories 21 32138785
2022 Safety evaluation of Fy Protein™ (Nutritional Fungi Protein), a macroingredient for human consumption. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 19 35636642
2018 A 2'FY-RNA Motif Defines an Aptamer for Ebolavirus Secreted Protein. Scientific reports 19 30120364
2011 Hypomorphic alleles reveal FCA-independent roles for FY in the regulation of FLOWERING LOCUS C. Plant physiology 17 21209277
2009 Survey of rice proteins interacting with OsFCA and OsFY proteins which are homologous to the Arabidopsis flowering time proteins, FCA and FY. Plant & cell physiology 16 19561057
2015 Duffy blood group phenotype-genotype correlations using high-resolution melting analysis PCR and microarray reveal complex cases including a new null FY*A allele: the role for sequencing in genotyping algorithms. Vox sanguinis 15 25900316
2014 A novel FY*A allele with the 265T and 298A SNPs formerly associated exclusively with the FY*B allele and weak Fy(b) antigen expression: implication for genotyping interpretative algorithms. Vox sanguinis 14 25092430
2012 Novel colicin Fy of Yersinia frederiksenii inhibits pathogenic Yersinia strains via YiuR-mediated reception, TonB import, and cell membrane pore formation. Journal of bacteriology 14 22343298
2021 Pan-cancer investigation reveals mechanistic insights of planar cell polarity gene Fuz in carcinogenesis. Aging 13 33658400
2003 Induction of Duffy gene (FY) in human endothelial cells and in mouse. Cytokine 13 12697152
1987 Incidence and some characteristics of fimbriae FY and 31A of Escherichia coli isolates from calves with diarrhea in Japan. Microbiology and immunology 13 2889130
1990 IP3 levels and their modulation FY fusicoccin measured by a novel [3H] IP3 binding assay. Biochemical and biophysical research communications 12 2346477
1989 The genes for apolipoprotein all (APOA2) and the Duffy blood group (FY) are linked on chromosome 1 in man. Genomics 11 2500391
1977 Relative positions of chromosome 1 loci Fy, PGM1, Sc, UMPK, Rh, PGD and ENO1 in man. Canadian journal of genetics and cytology. Journal canadien de genetique et de cytologie 11 416891
2024 Evaluation of population immunity against SARS-CoV-2 variants, EG.5.1, FY.4, BA.2.86, JN.1, JN.1.4, and KP.3.1.1 using samples from two health demographic surveillance systems in Kenya. BMC infectious diseases 10 39732637
2022 Reclassification of Enterobacter sp. FY-07 as Kosakonia oryzendophytica FY-07 and Its Potential to Promote Plant Growth. Microorganisms 10 35336150
2005 Components of the Arabidopsis autonomous floral promotion pathway, FCA and FY, are conserved in monocots. Functional plant biology : FPB 9 32689136
1984 A patient, mosaic for Rh and Fy antigens lacking other signs of chimerism or chromosomal disorder. Vox sanguinis 9 6431693
2023 The Fuzzy planar cell polarity protein (FUZ), necessary for primary cilium formation, is essential for pituitary development. Journal of anatomy 8 37794731
1995 N-[2-[N'-pentyl-(6,6-dimethyl-2,4-heptadiynyl)amino]ethyl]- (2-methyl-1-naphthylthio)acetamide (FY-087). A new acyl coenzyme a:cholesterol acyltransferase (ACAT) inhibitor of diet-induced atherosclerosis formation in mice. Biochemical pharmacology 8 7887979
1987 Study of anti-Fya in five black Fy(a-b-) patients. Vox sanguinis 8 3604183
2018 In vitro study of FUZ as a novel potential therapeutic target in non-small-cell lung cancer. Life sciences 7 29421438
1975 U.S. organized family planning programs in FY 1974. Family planning perspectives 7 1095399
2015 FY*A silencing by the GATA-motif variant FY*A(-69C) in a Caucasian family. Transfusion 6 26173389
2013 Unique activity spectrum of colicin FY: all 110 characterized Yersinia enterocolitica isolates were colicin FY susceptible. PloS one 6 24339971
2011 Dual roles for FY in the regulation of FLC. Plant signaling & behavior 6 21633188
2001 Rapid genotyping of the major alleles at the Duffy (FY) blood group locus using real-time fluorescence polymerase chain reaction. Immunohematology 6 15373590
2022 Fuzzy Planar Cell Polarity Gene (FUZ) Promtes Cell Glycolysis, Migration, and Invasion in Non-small Cell Lung Cancer via the Phosphoinositide 3-Kinase/Protein Kinase B Pathway. Journal of Cancer 5 35711836
2020 Duffy phenotyping and FY*B-67T/C genotyping as screening test for benign constitutional neutropenia. Hematology, transfusion and cell therapy 4 33184016
2009 Knockdown resistance in pyrethroid-resistant horn fy (Diptera: Muscidae) populations in Brazil. Revista brasileira de parasitologia veterinaria = Brazilian journal of veterinary parasitology : Orgao Oficial do Colegio Brasileiro de Parasitologia Veterinaria 4 19772769
1988 Linkage between the expressed hypervariable gene locus PUM and the gene coding for the Duffy blood group FY. Annals of human genetics 4 3268038
2022 Association between FY*02N.01 and the severity of COVID-19: initial observations. Hematology, transfusion and cell therapy 3 35083424
2022 An Unusual Case of Delayed Hemolytic Transfusion Reaction With Hyperhemolysis Syndrome Due to Anti-Jkb and Anti-Fya Alloantibodies. Journal of hematology 3 35573755
2021 Anti-Fya-mediated delayed hemolytic transfusion reaction following emergency-release red blood cell transfusion: possible involvement of HLA-DRB1*04:03 in the Japanese population. International journal of hematology 3 34714525
2020 Estimated prevalence of the Duffy null phenotype Fy (a-b-) among black blood-donors in Southwestern Colombia. Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis 3 32718831
2018 Erythrocyte-binding assays reveal higher binding of Plasmodium knowlesi Duffy binding protein to human Fya+/b+ erythrocytes than to Fya+/b- erythrocytes. Parasites & vectors 3 30257710
2015 First example of an FY*01 allele associated with weakened expression of Fya on red blood cells. Immunohematology 3 26829175
2013 Molecular characterization of the Fy(a-b-) phenotype in a Polish family. Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis 3 23820435
2006 Detection of antibodies reacting with the antithetical duffy blood group antigens Fy(a) and Fy(b) using recombinant fusion proteins containing the duffy extracellular domain. Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis 3 17113828
2025 Emergence and transmission dynamics of the FY.4 Omicron variant in Kenya. Virus evolution 2 40574750
2024 Linkage between Fuz and Gpr161 genes regulates sonic hedgehog signaling during mouse neural tube development. Development (Cambridge, England) 2 39369306
2020 Complete Genome Sequence of Serratia marcescens FY, Isolated from Drosophila melanogaster. Microbiology resource announcements 2 33153999
2018 Identification of Anti-Gerbich Antibody in an Emirati Marrow Hematopoietic Progenitor Cell Donor with Fy(a-b-) Phenotype. Yonsei medical journal 2 30450861
2017 Genetic variants related to disease susceptibility and immunotolerance in the Duffy antigen receptor for chemokines (DARC, Fy) gene in the black lion tamarin (Leontopithecus chrysopygus, primates). American journal of primatology 2 28902417
2016 Duffy blood group (Fya & Fyb) analysis using surface plasmon resonance. Biomedical microdevices 2 27787763
2011 Do FY antigens act as minor histocompatibility antigens in the graft-versus-host disease paradigm after human leukocyte antigen-identical sibling hematopoietic stem cell transplantation? DNA and cell biology 2 21770738
2024 The novel linkage between Fuz and Gpr161 genes regulates sonic hedgehog signaling during mouse embryonic development. bioRxiv : the preprint server for biology 1 38260275
2024 Disruption of Fuz in mouse embryos generates hypoplastic hindbrain development and reduced cranial nerve ganglia. Developmental dynamics : an official publication of the American Association of Anatomists 1 38501709
2024 Inducible biosynthesis of bacterial cellulose in recombinant Enterobacter sp. FY-07. International journal of biological macromolecules 1 38986995
2024 Pseudomonas ZY-1 and Bacillus FY-1 protecting the rice seedlings from the harm of Pseudomonas aeruginosa via indirect seawead lysis. BMC microbiology 1 39342144
2024 Hemolytic Disease of the Fetus and Newborn Caused by Maternal Alloanti-Fy(a). Cureus 1 39403655
2023 Relationship between antihypertensive drug use and number of people with high blood pressure in FY 2018: a descriptive epidemiological study based on the National Database of Health Insurance Claims and Specific Health Checkups of Japan open data. Journal of pharmaceutical health care and sciences 1 38066634
2015 Molecular identification of rare FY*Null and FY*X alleles in Caucasian thalassemic family from Sardinia. Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis 1 25921504
2012 [Application of melting curve to analyze genotype of Duffy blood group antigen Fy-a/b]. Zhongguo shi yan xue ye xue za zhi 1 23257458
2011 Immunostimulatory activities of a decapeptide derived from Alcaligenes faecalis FY-3 to crucian carp. Scandinavian journal of immunology 1 21332568
2005 Living donor liver transplantation in a recipient with anti-Fy(a) and Jk(a) antibodies. Hepato-gastroenterology 1 15816488
2026 Phenotypic Expansion and Molecular Implications in Recessive FUZ-Related Ciliopathy. Clinical genetics 0 41952398
2025 Phenotypic and Genotypic Association of the Duffy Blood Group Antigens (Fya, Fyb) in Healthy Blood Donors. Journal of the College of Physicians and Surgeons--Pakistan : JCPSP 0 40843558
2025 Identification of novel interacting proteins of FUZ and GPR161. bioRxiv : the preprint server for biology 0 41000683
2023 Disruption of Fuz in mouse embryos generates hypoplastic hindbrain development and reduced cranial nerve ganglia. bioRxiv : the preprint server for biology 0 37577618
2020 Two Genetically Distinct Plasmodium knowlesi Duffy Binding Protein Alpha Region II (PkDBPαII) Haplotypes Demonstrate Higher Binding Level to Fy(a+b+) Erythrocytes than Fy(a+b--) Erythrocytes. The American journal of tropical medicine and hygiene 0 32189613