Affinage

PA2G4

Proliferation-associated protein 2G4 · UniProt Q9UQ80

Length
394 aa
Mass
43.8 kDa
Annotated
2026-04-29
100 papers in source corpus 45 papers cited in narrative 45 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

PA2G4 (EBP1) is a multifunctional RNA- and DNA-binding protein with a catalytically inactive methionine aminopeptidase (pita-bread) fold that acts as a context-dependent regulator of transcription, translation, ribosome biogenesis, and mitophagy. In the nucleus, the p48 isoform recruits HDAC2 and the corepressor Sin3A via its C-terminal domain to repress E2F1- and androgen receptor-regulated promoters, while the p42 isoform undergoes TLS/FUS-mediated sumoylation at K93/K298 for nuclear translocation and additionally promotes proteasomal degradation of the PI3K p85 subunit through recruitment of the HSP70/CHIP E3 ligase (PMID:12682367, PMID:16254079, PMID:19946338, PMID:24651434). In the cytoplasm, PA2G4 binds the 60S ribosomal subunit at the peptide exit tunnel—contacting eL19, uL23, and 28S rRNA—to regulate co-translational events, inhibits eIF2α phosphorylation via its dsRNA-binding domain, and stabilizes bcl-2 mRNA (PMID:33357414, PMID:16631606, PMID:16396631). PA2G4 also participates in cell survival signaling through PKCδ-dependent S360 phosphorylation enabling nuclear Akt interaction, protects MYCN from proteolysis in neuroblastoma, and is ubiquitinated at K376 by PARKIN on damaged mitochondria to recruit SQSTM1/p62 and trigger neuroprotective mitophagy (PMID:16642037, PMID:31501192, PMID:37712850).

Mechanistic history

Synthesis pass · year-by-year structured walk · 18 steps
  1. 2000 High

    Identifying EBP1 as an ErbB3-interacting protein established it as a signaling-responsive factor: heregulin dissociates EBP1 from ErbB3 and triggers its nuclear translocation, linking receptor tyrosine kinase signaling to nuclear function.

    Evidence Yeast two-hybrid, Co-IP, in vitro binding with domain mapping, subcellular fractionation in breast cancer cells

    PMID:10682683

    Open questions at the time
    • Direct structural basis of ErbB3–EBP1 interaction unresolved
    • Downstream nuclear targets upon translocation unknown at this stage
  2. 2001 High

    Demonstrating that EBP1 binds Rb and represses E2F1-regulated cyclin E promoter activity established a nuclear transcriptional repressor function, while PKC-dependent phosphorylation was shown to regulate ErbB3 association, revealing the first post-translational control mechanism.

    Evidence Co-IP, GST pulldown with domain mapping, reporter assays (Rb binding); in vitro kinase assay with PKC inhibitors (phosphorylation)

    PMID:11268000 PMID:11325528

    Open questions at the time
    • Identity of recruited chromatin-modifying complexes not yet known
    • Phosphorylation sites on EBP1 not yet mapped
  3. 2003 High

    Showing that EBP1 recruits HDAC2 (but not HDAC1) through its C-terminal domain to mediate transcriptional repression resolved how EBP1 silences E2F targets at the chromatin level.

    Evidence GST pulldown, HDAC activity assay, HDAC inhibitor treatment, deletion mutagenesis, reporter assays

    PMID:12682367

    Open questions at the time
    • Whether HDAC2 recruitment is sufficient or requires additional corepressors not addressed
  4. 2002 High

    Identification of EBP1 as an androgen receptor corepressor via an LXXLL motif extended its transcriptional repressor function beyond E2F to nuclear hormone receptor signaling.

    Evidence Co-IP, GST pulldown with domain mapping, reporter assays with LXXLL mutagenesis in prostate cancer cells

    PMID:12165860

    Open questions at the time
    • Whether AR repression involves HDAC recruitment not yet tested
  5. 2004 High

    Establishing that EBP1 localizes to the nucleolus, associates with rRNP complexes, and inhibits proliferation linked this protein to ribosome biogenesis and demonstrated that nucleolar targeting requires both N- and C-terminal sequences.

    Evidence Confocal immunofluorescence, mass spectrometry, subcellular fractionation, proliferation assays

    PMID:15064750

    Open questions at the time
    • Specific rRNA processing steps regulated by EBP1 not identified
  6. 2005 High

    ChIP showing EBP1 occupancy at the E2F1 promoter together with Rb and HDAC2, and identification of Sin3A as a direct EBP1-binding corepressor, completed the model of a ternary repressive complex at E2F- and AR-regulated genes.

    Evidence ChIP, DNA affinity pulldown, GST pulldown with domain mapping for Sin3A, reporter assays

    PMID:15073182 PMID:15994225 PMID:16254079

    Open questions at the time
    • Genome-wide target spectrum of this repressive complex not defined
  7. 2006 High

    Discovery of two functionally distinct isoforms (p48 and p42), PKCδ-mediated S360 phosphorylation protecting EBP1 from caspase-3 cleavage, nuclear Akt interaction, dsRNA binding mediating ribosome association and eIF2α regulation, and bcl-2 mRNA stabilization collectively revealed EBP1 as a multifunctional regulator of translation, survival, and differentiation.

    Evidence Multiple orthogonal methods across four studies: subcellular fractionation, Co-IP, in vitro kinase assays, mutagenesis, dsRNA binding assays, ribosome fractionation, RNA affinity chromatography, mRNA decay assays

    PMID:16396631 PMID:16631606 PMID:16642037 PMID:16832058 PMID:17316401

    Open questions at the time
    • Structural basis for isoform-specific localization and partner selection unknown
    • Precise mechanism of eIF2α phosphorylation inhibition not resolved
  8. 2007 High

    Crystal structures of murine and human EBP1 revealed a catalytically inactive methionine aminopeptidase fold with a C-terminal RNA-binding extension, while functional studies identified nucleophosmin/B23 interaction required for ribosome biogenesis and S363 phosphorylation controlling HDAC2/Sin3A recruitment.

    Evidence X-ray crystallography (1.6–2.0 Å), mutagenesis, IRES translation assay, Co-IP with B23, ribosome biogenesis assay, phospho-specific antibodies, ChIP

    PMID:17690690 PMID:17765895 PMID:17786317 PMID:17951246

    Open questions at the time
    • No co-crystal with RNA or protein partners at this time
    • How B23 sumoylation state toggles isoform-specific binding not structurally resolved
  9. 2008 High

    Identification of PAK1-mediated T261 phosphorylation as a switch that inactivates EBP1 transcriptional repression, and hBre1 as an E3 ligase promoting EBP1 proteasomal degradation, established kinase and ubiquitin-mediated layers of EBP1 regulation.

    Evidence In vitro kinase assay with site mapping, Co-IP, reporter assays (PAK1); in vitro ubiquitination reconstitution, siRNA (hBre1)

    PMID:18283314 PMID:19037095

    Open questions at the time
    • Whether PAK1 and PKCδ phosphorylation are coordinated is unknown
    • Full ubiquitin chain topology on EBP1 not defined
  10. 2009 High

    Demonstrating TLS/FUS-mediated sumoylation of p42 at K93/K298 as required for nuclear translocation and E2F1 repression explained how the cytoplasmic p42 isoform gains nuclear repressor function under genotoxic stress.

    Evidence In vitro sumoylation assay, Co-IP, mutagenesis, reporter assays, subcellular fractionation

    PMID:19946338

    Open questions at the time
    • Desumoylation enzymes acting on EBP1 not identified
    • Genotoxic stress signals upstream of TLS/FUS not fully mapped
  11. 2010 High

    Showing that p48 enhances HDM2-mediated p53 polyubiquitination and degradation established EBP1 as a modulator of the p53 tumor suppressor pathway in glioblastoma.

    Evidence Co-IP, ubiquitination assay, p53 protein level measurement in glioblastoma cells

    PMID:21098709

    Open questions at the time
    • Whether this function is isoform-specific to p48 not fully dissected
    • Physiological triggers for EBP1-HDM2 complex formation unclear
  12. 2014 High

    Two parallel discoveries showed that p42 promotes PI3K p85 degradation by recruiting HSP70/CHIP, directly inhibiting PI3K signaling, while CDK2 phosphorylates p48 at S34 to enable its oncogenic function—delineating isoform-specific oncogenic versus tumor-suppressive activities.

    Evidence Co-IP, in vitro PI3K activity assay, ubiquitination assay, in vitro kinase assay, mutagenesis, xenograft models

    PMID:24651434 PMID:25154617

    Open questions at the time
    • Whether CDK2 phosphorylation of p48 affects ribosome binding unknown
    • How HSP70/CHIP is specifically recruited by p42 but not p48 not resolved structurally
  13. 2016 High

    Identification of polyphosphoinositide binding via lysine-rich motifs, with the C-terminal motif governing nucleolar targeting and a cancer-associated K372N mutation disrupting it, established a lipid-signaling input for EBP1 localization.

    Evidence Lipid pulldown, NMR, mutagenesis, immunofluorescence

    PMID:27918868

    Open questions at the time
    • Whether PPIn binding competes with RNA binding at overlapping motifs not tested
    • Functional consequence of K372N in tumorigenesis not demonstrated in vivo
  14. 2017 High

    Discovery that p48 and p42 differentially interact with FBXW7 E3 ligase—p48 as an oncogenic substrate sequestering FBXW7α, p42 as an adapter promoting FBXW7-mediated degradation of oncoproteins—provided a unified framework for the opposing roles of the two isoforms.

    Evidence Co-IP, subcellular fractionation, ubiquitination assay, domain mapping

    PMID:28209614

    Open questions at the time
    • Identity of all FBXW7 substrates whose turnover is modulated by p42 not catalogued
    • In vivo validation in genetic models lacking
  15. 2019 High

    Multiple 2019 studies revealed new EBP1 functions: direct binding and stabilization of MYCN in neuroblastoma; interaction with HNF4α via the LXXLL motif (co-crystal at 3.15 Å); promotion of Suv39H1 degradation via MDM2 recruitment to regulate heterochromatin in neural development; and regulation of rDNA transcription through a circERBB2–PA2G4–TIFIA axis.

    Evidence SPR and mutagenesis with in vivo tumor models (MYCN); X-ray crystallography and reporter assays (HNF4α); Co-IP, ubiquitination assay, KO mouse (Suv39H1); RNA pulldown and RIP with xenograft (circERBB2)

    PMID:31362984 PMID:31501192 PMID:31748268 PMID:31752867

    Open questions at the time
    • Structural basis of full-length MYCN–PA2G4 complex not determined
    • Whether Suv39H1 degradation is isoform-specific is unclear
    • circERBB2 finding from single lab
  16. 2020 High

    Cryo-EM structures of EBP1 bound to the human 80S ribosome at the peptide exit tunnel resolved how EBP1 contacts eL19, uL23, and 28S rRNA, and showed that translational arrest enhances binding while emerging signal sequences displace it, establishing EBP1 as a ribosome-associated factor sensing translational state.

    Evidence Cryo-EM at 3.3 Å, ribosome profiling, pSILAC/BONCAT mass spectrometry; independently confirmed by a second cryo-EM study

    PMID:33357414 PMID:33479117

    Open questions at the time
    • Functional consequence of EBP1 at the exit tunnel on nascent chain folding or targeting not demonstrated
    • Whether p42 binds ribosomes similarly to p48 not structurally addressed
  17. 2023 High

    Demonstration that PARKIN ubiquitinates PA2G4 at K376 on damaged mitochondria, enabling SQSTM1/p62 recruitment and mitophagy, with neuron-specific KO increasing ischemic infarct volume, established a neuroprotective mitophagy role for PA2G4.

    Evidence Ubiquitination site mapping, Co-IP, neuron-specific KO mouse, AAV rescue, mitophagy assays

    PMID:37712850

    Open questions at the time
    • Whether mitophagy function is isoform-specific not determined
    • How PA2G4 is recruited to damaged mitochondria upstream of PARKIN ubiquitination is unclear
  18. 2025 High

    Identification of PA2G4 as a stabilizer of NF110 (in an NF110-NF45 heterodimer) that is competitively displaced by the piRNA CRAPIR to promote cardiomyocyte proliferation extended PA2G4 function to cardiac regeneration.

    Evidence Reciprocal Co-IP, RNA pulldown, CRISPR KO, AAV overexpression, in vivo cardiac injury model

    PMID:39814981

    Open questions at the time
    • Whether NF110 stabilization depends on EBP1 isoform identity not examined
    • Mechanism by which NF110 degradation promotes cardiomyocyte cell cycle re-entry not fully resolved

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key unresolved questions include: how PA2G4 toggles between ribosomal, nuclear transcriptional, and mitochondrial functions in the same cell; what determines isoform-specific partner selection at the structural level; and whether EBP1's exit-tunnel binding directly regulates nascent polypeptide fate.
  • No integrative model of isoform-specific subcellular trafficking
  • No co-structure of EBP1 with full-length nuclear partners (AR, Rb, MYCN)
  • Genome-wide or translatome-wide target specificity not comprehensively profiled

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140110 transcription regulator activity 7 GO:0003723 RNA binding 6 GO:0098772 molecular function regulator activity 5 GO:0060090 molecular adaptor activity 2 GO:0008289 lipid binding 1 GO:0042393 histone binding 1
Localization
GO:0005634 nucleus 6 GO:0005730 nucleolus 4 GO:0005829 cytosol 3 GO:0005840 ribosome 3 GO:0005739 mitochondrion 1
Pathway
R-HSA-74160 Gene expression (Transcription) 7 R-HSA-162582 Signal Transduction 5 R-HSA-392499 Metabolism of proteins 3 R-HSA-5357801 Programmed Cell Death 3 R-HSA-1266738 Developmental Biology 2 R-HSA-1640170 Cell Cycle 2 R-HSA-4839726 Chromatin organization 2 R-HSA-9612973 Autophagy 1
Partners
AKT1ERBB3HDAC2MDM2MYCNNPM1RB1SIN3A
Complex memberships
80S ribosome (exit tunnel-associated)EBP1-Sin3A-HDAC2 corepressor complexZFP809-TRIM28 retroviral silencing complex

Evidence

Reading pass · 45 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2000 Ebp1 (PA2G4) interacts with the juxtamembrane domain of ErbB-3, with the first 15 amino acids of the juxtamembrane domain essential for binding in vitro; heregulin treatment causes dissociation of Ebp1 from ErbB-3 and translocation of Ebp1 from the cytoplasm to the nucleus. Yeast two-hybrid, in vitro binding assay, co-immunoprecipitation, subcellular fractionation/immunofluorescence British journal of cancer High 10682683
2001 Ebp1 binds the retinoblastoma protein (Rb) both in vivo and in vitro; the 72 C-terminal amino acids of Ebp1 are sufficient for Rb binding; dephosphorylation of Ebp1 enhances binding to Rb; Ebp1 inhibits E2F1-regulated cyclin-E promoter activity and binds E2F1 indirectly via Rb. Co-immunoprecipitation, GST pulldown, reporter gene assay, confocal immunofluorescence Journal of cellular physiology High 11268000
2003 Ebp1 represses E2F-regulated transcription via its C-terminal domain, which binds HDAC activity; Ebp1 binds HDAC2 (but not HDAC1) in vitro; HDAC inhibitors reduce Ebp1-mediated repression; an Ebp1 mutant lacking the HDAC-binding domain fails to repress transcription. Reporter gene assay, GST pulldown, HDAC activity assay, co-immunoprecipitation, mutagenesis Nucleic acids research High 12682367
2002 Ebp1 binds the androgen receptor (AR) in vitro and in vivo; binding is increased by androgen treatment; the C-terminal 79 amino acids of Ebp1 are sufficient to bind AR via its N-terminal domain; Ebp1 inhibits ligand-mediated AR transcriptional activation; an LXXLL motif in Ebp1 is required for this inhibition. Co-immunoprecipitation, GST pulldown, transient transfection reporter assay, mutagenesis Oncogene High 12165860
2004 Ebp1 is localized to the cytoplasm and nucleolus; nucleolar localization requires sequences at both N- and C-termini; Ebp1 overexpression inhibits proliferation linked to its nucleolar localization; Ebp1 is part of ribonucleoprotein complexes and associates with different rRNA species. Confocal immunofluorescence, subcellular fractionation, mass spectrometry, cell proliferation assay Oncogene High 15064750
2004 Heregulin regulates the association of Ebp1 with E2F1 promoter elements; Ebp1 binds E2F consensus sequences in nuclear lysates together with E2F1, Rb, and HDAC2; chromatin immunoprecipitation shows Ebp1 is recruited to the E2F1 promoter in vivo; HRG enhances Ebp1-mediated transcriptional repression. DNA affinity pulldown, chromatin immunoprecipitation (ChIP), reporter gene assay The Journal of biological chemistry High 15073182
2005 Ebp1 interacts with the corepressor Sin3A both in vitro and in vivo; the C-terminal domain of Ebp1 binds Sin3A (via PAD4/HDAC-interacting domain of Sin3A); Ebp1 and Sin3A associate at PSA and E2F1 promoters in vivo; Sin3A enhances Ebp1-mediated repression of AR- and E2F1-regulated genes. GST pulldown, co-immunoprecipitation, ChIP, DNA affinity precipitation, reporter gene assay Nucleic acids research High 16254079
2005 Ebp1 overexpression down-regulates AR and AR-regulated genes (including PSA); Ebp1 is recruited to the PSA promoter in response to the androgen antagonist bicalutamide as shown by ChIP; androgens fail to stimulate growth of ebp1 transfectants. Chromatin immunoprecipitation, microarray, reporter gene assay, in vivo xenograft Proceedings of the National Academy of Sciences of the United States of America High 15994225
2006 Nuclear Akt interacts with PKC-phosphorylated Ebp1 (at S360) to prevent DNA fragmentation by caspase-activated DNase (CAD); phospho-mimetic S360D mutant strongly binds nuclear Akt and suppresses apoptosis, while S360A mutant barely binds Akt or inhibits DNA fragmentation; nuclear (not cytoplasmic) Akt enhances Ebp1 antiapoptotic action independent of Akt kinase activity. Cell-free apoptotic assay, nuclear extract purification, Co-IP, site-directed mutagenesis, siRNA knockdown, overexpression The EMBO journal High 16642037
2006 Ebp1 has two isoforms, p48 and p42: p48 localizes to both cytoplasm and nucleus and suppresses apoptosis; p42 predominantly resides in cytoplasm and promotes differentiation; EGF stimulates p42 to bind ErbB3 in a PKC-phosphorylation-dependent manner; p48 does not bind ErbB3 regardless of EGF; p48 promotes cell proliferation while p42 inhibits it. Subcellular fractionation, co-immunoprecipitation, overexpression, siRNA knockdown, flow cytometry Proceedings of the National Academy of Sciences of the United States of America High 16832058
2006 Ebp1 contains a dsRNA-binding domain (dsRBD); this domain mediates interaction with dsRNA, is required for nucleolar localization, and for forming RNP complexes; in the cytoplasm, Ebp1 associates with mature ribosomes; Ebp1 inhibits phosphorylation of eIF2α at S51 and interacts with and is phosphorylated by PKR kinase. dsRNA-binding assay, co-immunoprecipitation, sucrose gradient fractionation, in vitro kinase assay, deletion mutagenesis, immunofluorescence Biochemical and biophysical research communications High 16631606
2006 Ebp1 is identified as a component of cytoplasmic bcl-2 mRNP complexes; recombinant Ebp1 binds bcl-2 ARE RNA but not GM-CSF ARE in vitro; Ebp1 co-precipitates with nucleolin from HL-60 cytoplasmic extracts in an RNA-dependent manner; Ebp1 decreases the rate of decay of bcl-2 ARE-containing transcripts in cell extracts. RNA affinity chromatography, MALDI-MS, EMSA, RNA co-immunoprecipitation, RNA decay assay The Biochemical journal High 16396631
2007 Crystal structure of murine Ebp1 (p48) reveals a core domain homologous to methionine aminopeptidases (pita bread fold), coupled to a C-terminal extension; the primary RNA-binding site is formed by a Lys-rich motif in the C-terminus mediating FMDV IRES interaction; the structure explains conformational differences between p42 and p48 isoforms and disposition of the LKALL protein-interacting motif. X-ray crystallography, mutagenesis, IRES translation assay The EMBO journal High 17690690
2007 Human Ebp1 crystal structure at 1.6 Å resolution reveals a conserved pita bread fold homologous to methionine aminopeptidases but without catalytic activity; the structure reveals how Ebp1 may discriminate between protein and RNA interaction partners. X-ray crystallography FEBS letters High 17765895
2007 Ebp1 specifically interacts with the PB1 subunit of influenza virus RNA polymerase at PB1's transcription primer binding site; Ebp1 inhibits in vitro RNA synthesis by the influenza virus RNA polymerase complex but not capped RNA endonuclease or RNA-cap binding activities; overexpression of Ebp1 interferes with influenza virus production. Yeast two-hybrid, in vitro Co-IP, in vitro RNA synthesis assay, overexpression Genes to cells High 17295834
2007 Ebp1 forms a complex with nucleophosmin/B23; p48 constitutively binds B23 in the nucleolus requiring B23 K263 sumoylation; p42 selectively binds unsumoylated B23 upon EGF stimulation, dependent on Ser360 phosphorylation; knockdown of B23 or Ebp1 substantially decreases ribosome biogenesis and cell survival. Co-immunoprecipitation, immunofluorescence co-localization, siRNA knockdown, ribosome biogenesis assay, site-directed mutagenesis The Journal of biological chemistry High 17951246
2007 Protein kinase C-delta phosphorylates Ebp1 at S360, protecting it from caspase-3 cleavage at D196 and D53 sites; PKCδ-deficient cells show robust Ebp1 cleavage; S360 phosphorylation suppresses caspase-3-mediated degradation; D196A mutant markedly protects cells from apoptosis. In vitro kinase assay, cell-free apoptotic assay, site-directed mutagenesis, PKCδ knockout cells Journal of neurochemistry High 17316401
2008 Human Bre1 acts as an E3 ubiquitin ligase for Ebp1, promoting its polyubiquitination and proteasomal degradation; Ebp1 polyubiquitination is regulated by its phosphorylation; depletion of hBre1 blocks Ebp1 polyubiquitination and elevates Ebp1 protein level; hBre1 suppresses Ebp1's repressive effect on E2F-1. In vitro ubiquitination assay, co-immunoprecipitation, siRNA knockdown, Western blot Molecular biology of the cell High 19037095
2009 Ebp1 p42 isoform is sumoylated on K93 and K298, which mediate its nuclear translocation and are required for anti-proliferative activity; TLS/FUS acts as a SUMO1 E3 ligase for Ebp1 p42; Ebp1 directly binds TLS/FUS; genotoxic stress-triggered phosphorylation of Ebp1 regulates this interaction; unsumoylated Ebp1 mutants fail to suppress E2F-1 transcription. Co-immunoprecipitation, in vitro sumoylation assay, site-directed mutagenesis, siRNA knockdown, reporter gene assay, subcellular fractionation Oncogene High 19946338
2010 p48 isoform of Ebp1 binds HDM2 (MDM2), enhancing HDM2-p53 association and promoting p53 polyubiquitination and degradation, thereby reducing steady-state p53 levels and activity in glioblastoma cells. Co-immunoprecipitation, ubiquitination assay, Western blot, overexpression/knockdown Cancer research High 21098709
2001 PKC phosphorylates Ebp1 on serine/threonine residues in vitro; basal Ebp1 phosphorylation in vivo is PKC-dependent; heregulin-induced phosphorylation is predominantly PKC-independent; PKC inhibition abrogates Ebp1 association with ErbB3. In vitro kinase assay, metabolic labeling/phosphorylation analysis, PKC inhibitor treatment, co-immunoprecipitation Molecular and cellular endocrinology High 11325528
2007 Ebp1 serine 363 is phosphorylated in vivo; phospho-S363 Ebp1 localizes exclusively to the nucleus; S363A mutation decreases transcriptional repression and abrogates cell growth inhibition; S363A mutant fails to bind HDAC2 and mSin3a despite associating with E2F1 promoter elements. Phospho-specific antibody, immunofluorescence, reporter gene assay, co-immunoprecipitation, ChIP International journal of oncology High 17786317
2008 PAK1 phosphorylates Ebp1 in vitro at threonine 261; HRG treatment and constitutively active PAK1 enhance threonine phosphorylation of Ebp1 in MCF-7 cells; endogenous Ebp1 binds PAK1 and association is enhanced by HRG; a phospho-mimetic T261E mutation abolishes Ebp1's ability to repress transcription, inhibit growth, and contribute to tamoxifen sensitivity. In vitro kinase assay, co-immunoprecipitation, site-directed mutagenesis, reporter gene assay, cell growth assay British journal of cancer High 18283314
2014 p42 Ebp1 interacts with the cSH2 domain of p85 (PI3K regulatory subunit), leading to inhibition of PI3K lipid kinase activity; p42 induces proteasomal degradation of p85 by recruiting the HSP70/CHIP E3 ligase complex, which ubiquitinates p85. Co-immunoprecipitation, in vitro PI3K activity assay, ubiquitination assay, Western blot, in vivo xenograft Cell death & disease High 24651434
2014 p48 Ebp1 interacts with CDK2 through its N-terminal domain; CDK2 specifically phosphorylates p48 at serine 34 (not p42); phospho-ablated S34A mutant antagonizes cell proliferation and transformation; CDK2-mediated S34 phosphorylation is required for p48's oncogenic function. Co-immunoprecipitation, in vitro kinase assay, site-directed mutagenesis, cell proliferation assay, mouse xenograft Molecular carcinogenesis High 25154617
2015 TIF-IA (a GTP-binding protein that recruits RNA Pol I to ribosomal DNA promoter) binds EBP1; together they enhance transcription of PCNA; GTP binding by TIF-IA and PKCδ-mediated EBP1 phosphorylation are both required for optimal PCNA expression and ribosomal RNA synthesis in T cells. Co-immunoprecipitation, reporter gene assay, kinase assay, pharmacological inhibition Blood Medium 25691158
2016 EBP1 binds directly to multiple polyphosphoinositides (PPIns) via two lysine-rich motifs at N- and C-termini; the C-terminal PPIn-binding motif is the major contributor to nucleolar localization; a K372N mutation (found in endometrial tumors) within the C-terminal motif alters nucleolar targeting; EBP1 associates with PtdIns(3,4,5)P3 in the nucleolus via electrostatic and hydrophobic interactions as shown by NMR. Lipid pulldown, mutagenesis, immunofluorescence, NMR The Biochemical journal High 27118868
2017 EBP1 P48 binds to the WD domain of FBXW7 as an oncogenic substrate and sequesters FBXW7α to the cytosol; EBP1 P42 binds to both the F-box domain of FBXW7 and FBXW7 substrates, acting as an adapter to promote FBXW7-mediated degradation of oncogenic targets. Co-immunoprecipitation, subcellular fractionation, ubiquitination assay, domain mapping Cancer research High 28209614
2019 MYCN directly occupies the PA2G4 gene promoter stimulating its transcription; PA2G4 directly binds MYCN protein protecting it from proteolysis; the MYCN-PA2G4 interaction site was mapped to a 14 amino acid MYCN sequence and a surface crevice of PA2G4; competitive chemical inhibition of this interface reduces MYCN and PA2G4 levels and inhibits neuroblastoma tumorigenesis in vivo. ChIP, surface plasmon resonance, mutagenesis, molecular modeling, in vivo tumor model Cancer research High 31501192
2019 circERBB2 regulates nucleolar localization of PA2G4, forming a circERBB2-PA2G4-TIFIA regulatory axis to modulate ribosomal DNA transcription and cancer cell proliferation. RNA pulldown, RNA immunoprecipitation, FISH, knockdown, in vivo xenograft Molecular cancer Medium 31752867
2019 EBP1 directly interacts with Suv39H1 and recruits the E3 ligase MDM2, promoting ubiquitin-proteasome-dependent degradation of Suv39H1 to regulate heterochromatin assembly during neural development; EBP1 also binds to the DNMT1 promoter, repressing DNA methylation. Co-immunoprecipitation, ChIP, ubiquitination assay, Western blot, KO mouse model Proceedings of the National Academy of Sciences of the United States of America High 31748268
2019 EBP1 binds HNF4α in a LXXLL motif-mediated manner; EBP1 suppresses expression of HNF4α target genes involved in insulin secretion; crystal structure of HNF4α ligand-binding domain in complex with EBP1 LXXLL peptide at 3.15 Å shows EBP1's LXXLL motif competes with HNF4α coactivators for the same binding pocket. Yeast two-hybrid, mammalian two-hybrid, GST pulldown, X-ray crystallography, reporter gene assay The Journal of biological chemistry High 31362984
2019 Ebp1 p48 interacts with TIF-90 (a splice variant of TIF-IA) to regulate ribosomal RNA synthesis; Ebp1 promotes Akt-mediated protection of TIF-90 stability by preventing TIF-90 ubiquitination by Mdm2 and its proteasomal degradation. Co-immunoprecipitation, ubiquitination assay, rRNA synthesis assay, knockdown/overexpression Journal of cellular physiology Medium 30793766
2020 Cryo-EM structure of human Ebp1 (p48) bound to the human 80S ribosome at 3.3 Å reveals Ebp1 binds in the vicinity of the peptide exit tunnel, interacting with ribosomal proteins eL19 and uL23 and 28S rRNA; Ebp1-80S binding is enhanced upon puromycin-mediated translational inhibition; Ebp1 can rotate around its insert domain; membrane-targeting domains emerging from the 60S tunnel displace Ebp1. Cryo-EM, ribosome profiling, pSILAC/BONCAT mass spectrometry Molecular cell High 33357414
2021 Cryo-EM structure of human Ebp1 (p48 isoform) bound to the human 80S ribosome at 3.3 Å: Ebp1 binds near the peptide exit tunnel via interactions with eL19, uL23, and 28S rRNA; binding is enhanced by puromycin-induced translational arrest; Ebp1 can rotate around its insert domain providing conformational flexibility at the ribosome. Cryo-EM, sucrose gradient ribosome fractionation RNA (New York, N.Y.) High 33479117
2021 EBP1 promotes UPS-dependent degradation of Suv39H1 by directly interacting with it and recruiting E3 ligase MDM2; this mechanism governs heterochromatin assembly and neural development. Co-immunoprecipitation, ubiquitination assay, Western blot BMB reports Medium 33691908
2023 PA2G4/EBP1 is ubiquitinated at lysine 376 by PRKN/PARKIN on damaged mitochondria; ubiquitinated PA2G4 interacts with the mitophagy receptor SQSTM1/p62 to induce mitophagy, promoting neuroprotection during cerebral ischemia-reperfusion injury; neuron-specific Ebp1 KO increases infarct volume and impairs mitophagy. Co-immunoprecipitation, ubiquitination mapping, neuron-specific KO mouse, AAV rescue, mitophagy assay Autophagy High 37712850
2022 PA2G4 promotes HCC metastasis by stabilizing FYN mRNA through interaction with the m6A reader YTHDF2; FYN mRNA is m6A-modified and bound by both PA2G4 and YTHDF2; YTHDF2's m6A catalytic activity is indispensable for PA2G4-mediated regulation of FYN. Co-immunoprecipitation, RIP, MeRIP, RNA half-life assay, dual luciferase reporter, in vivo lung metastasis model Cell & bioscience Medium 35526051
2025 PA2G4 binds the NF110-NF45 heterodimer and prevents NF110 degradation; CRAPIR (a PIWI-interacting RNA) competes with NF110 for binding to PA2G4, thereby preventing PA2G4-NF110 interaction, reducing NF110 degradation, and promoting cardiomyocyte proliferation and heart regeneration. Co-immunoprecipitation, RNA pulldown, CRISPR knockout, antagomir knockdown, AAV overexpression, in vivo cardiac injury model Nature cardiovascular research High 39814981
2013 EBP1 is a novel component of the ZFP809-TRIM28 retroviral silencing complex; EBP1 depletion reduces PBS-mediated retroviral silencing of Moloney murine leukemia virus in embryonic cells. Co-immunoprecipitation (complex identification), siRNA knockdown, retroviral reporter assay Journal of virology Medium 24227866
2016 Pa2G4 (EBP1) binds to Six1 in human embryonic kidney cells and interferes with the Six1-Eya1 complex; in Xenopus, knockdown of Pa2G4 downregulates neural border zone, neural crest and cranial placode genes while expanding neural plate genes, demonstrating a role in neural crest and otic development. Co-immunoprecipitation (mammalian cells), morpholino knockdown in Xenopus, in situ hybridization Developmental biology Medium 27940157
2018 DPPA4 preferentially binds EBP1 p48 isoform in pluripotent cells via DPPA4's SAP domain; DPPA4 transcriptional repressive function is increased by p48 knockdown; this effect is abolished with an interaction-deficient DPPA4 ΔSAP mutant. Proteomics screen, co-immunoprecipitation, siRNA knockdown, reporter gene assay, mutagenesis Stem cells (Dayton, Ohio) Medium 29327467
2017 p48 Ebp1 physically interacts with beta-tubulin (but not alpha-tubulin) and accumulates in distal microtubule growth cone regions in neurons; introduction of p48 Ebp1 promotes axon regeneration in injured hippocampal slices. Co-immunoprecipitation, immunofluorescence, ex vivo axon regeneration assay BMB reports Low 27916024
2011 EBP1 inhibits translation of androgen receptor mRNA in castration-resistant prostate cancer cells without altering AR mRNA steady-state levels or stability; heregulin further diminishes AR translation in EBP1-transfected cells. Polysome fractionation, Western blot, quantitative PCR, mRNA stability assay Anticancer research Medium 21965718
2012 EBP1 decreases ErbB2 mRNA primarily through a transcriptional mechanism; EBP1 binds both distal and proximal endogenous ErbB2 promoters in vivo; Sin3A-interaction mutants of EBP1 have reduced ability to decrease ErbB2 promoter activity; EBP1 overexpression or ablation does not alter ErbB2 mRNA stability. ChIP, reporter gene assay, mRNA stability assay, site-directed mutagenesis, shRNA knockdown Oncology reports Medium 23242156

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1988 Purification of the human immunodeficiency virus type 1 enhancer and TAR binding proteins EBP-1 and UBP-1. The EMBO journal 195 3138113
2006 EBP1 regulates organ size through cell growth and proliferation in plants. The EMBO journal 143 17024182
2000 Interaction of the PA2G4 (EBP1) protein with ErbB-3 and regulation of this binding by heregulin. British journal of cancer 113 10682683
2004 EBP1 is a nucleolar growth-regulating protein that is part of pre-ribosomal ribonucleoprotein complexes. Oncogene 110 15064750
2006 Nuclear Akt associates with PKC-phosphorylated Ebp1, preventing DNA fragmentation by inhibition of caspase-activated DNase. The EMBO journal 106 16642037
2006 Ebp1 isoforms distinctively regulate cell survival and differentiation. Proceedings of the National Academy of Sciences of the United States of America 102 16832058
2007 Structural insights into the transcriptional and translational roles of Ebp1. The EMBO journal 91 17690690
2005 The ErbB3-binding protein Ebp1 suppresses androgen receptor-mediated gene transcription and tumorigenesis of prostate cancer cells. Proceedings of the National Academy of Sciences of the United States of America 84 15994225
2003 Repression of E2F1-mediated transcription by the ErbB3 binding protein Ebp1 involves histone deacetylases. Nucleic acids research 82 12682367
2001 Ebp1, an ErbB-3 binding protein, interacts with Rb and affects Rb transcriptional regulation. Journal of cellular physiology 82 11268000
2000 Ectopic expression of the ErbB-3 binding protein ebp1 inhibits growth and induces differentiation of human breast cancer cell lines. Journal of cellular physiology 82 10797306
2019 Circular RNA circERBB2 promotes gallbladder cancer progression by regulating PA2G4-dependent rDNA transcription. Molecular cancer 75 31752867
2005 The ErbB3 binding protein Ebp1 interacts with Sin3A to repress E2F1 and AR-mediated transcription. Nucleic acids research 74 16254079
2006 Ebp1 is a dsRNA-binding protein associated with ribosomes that modulates eIF2alpha phosphorylation. Biochemical and biophysical research communications 68 16631606
2002 Repression of androgen receptor mediated transcription by the ErbB-3 binding protein, Ebp1. Oncogene 66 12165860
2008 Human BRE1 is an E3 ubiquitin ligase for Ebp1 tumor suppressor. Molecular biology of the cell 64 19037095
2018 EBP1 nuclear accumulation negatively feeds back on FERONIA-mediated RALF1 signaling. PLoS biology 63 30339663
2007 The crystal structure of Ebp1 reveals a methionine aminopeptidase fold as binding platform for multiple interactions. FEBS letters 61 17765895
1988 Identification and purification of EBP1: a HeLa cell protein that binds to a region overlapping the 'core' of the SV40 enhancer. Genes & development 60 2844627
2008 EBP1, an ErbB3-binding protein, is decreased in prostate cancer and implicated in hormone resistance. Molecular cancer therapeutics 54 18852121
2008 Alterations in cell growth and signaling in ErbB3 binding protein-1 (Ebp1) deficient mice. BMC cell biology 54 19094237
2013 ErbB3 binding protein-1 (Ebp1) controls proliferation and myogenic differentiation of muscle stem cells. Developmental biology 53 24275324
2006 Identification of Ebp1 as a component of cytoplasmic bcl-2 mRNP (messenger ribonucleoprotein particle) complexes. The Biochemical journal 53 16396631
2010 Negative regulation of p53 by the long isoform of ErbB3 binding protein Ebp1 in brain tumors. Cancer research 52 21098709
2007 Ebp1 association with nucleophosmin/B23 is essential for regulating cell proliferation and suppressing apoptosis. The Journal of biological chemistry 51 17951246
2004 Heregulin regulates the ability of the ErbB3-binding protein Ebp1 to bind E2F promoter elements and repress E2F-mediated transcription. The Journal of biological chemistry 48 15073182
2014 P42 Ebp1 regulates the proteasomal degradation of the p85 regulatory subunit of PI3K by recruiting a chaperone-E3 ligase complex HSP70/CHIP. Cell death & disease 46 24651434
1997 Molecular cloning and mapping of a human cDNA (PA2G4) that encodes a protein highly homologous to the mouse cell cycle protein p38-2G4. Cytogenetics and cell genetics 44 9345902
2023 PA2G4/EBP1 ubiquitination by PRKN/PARKIN promotes mitophagy protecting neuron death in cerebral ischemia. Autophagy 42 37712850
2020 Protein Synthesis in the Developing Neocortex at Near-Atomic Resolution Reveals Ebp1-Mediated Neuronal Proteostasis at the 60S Tunnel Exit. Molecular cell 41 33357414
2009 Ebp1 sumoylation, regulated by TLS/FUS E3 ligase, is required for its anti-proliferative activity. Oncogene 41 19946338
2001 Analysis of the expression pattern of Ebp1, an ErbB-3-binding protein. Biochemical and biophysical research communications 41 11708806
1990 Interaction of enhancer-binding protein EBP1 (NF-kappa B) with the human immunodeficiency virus type 1 enhancer. Journal of virology 41 2406459
1989 Sequence requirement for specific interaction of an enhancer binding protein (EBP1) with DNA. Nucleic acids research 41 2536920
2007 Differential regulation of primitive myelopoiesis in the zebrafish by Spi-1/Pu.1 and C/ebp1. Zebrafish 40 18041923
2013 Ebp1 activates podoplanin expression and contributes to oral tumorigenesis. Oncogene 37 23975429
2007 Host factor Ebp1: selective inhibitor of influenza virus transcriptase. Genes to cells : devoted to molecular & cellular mechanisms 37 17295834
2005 Specificity and heregulin regulation of Ebp1 (ErbB3 binding protein 1) mediated repression of androgen receptor signalling. British journal of cancer 36 15583694
2015 Regulation of ribosomal RNA synthesis in T cells: requirement for GTP and Ebp1. Blood 35 25691158
2008 Inhibition of heregulin mediated MCF-7 breast cancer cell growth by the ErbB3 binding protein EBP1. Cancer letters 30 18355957
2007 Suppression of salivary adenoid cystic carcinoma growth and metastasis by ErbB3 binding protein Ebp1 gene transfer. International journal of cancer 30 17266032
2017 Distinct Interactions of EBP1 Isoforms with FBXW7 Elicits Different Functions in Cancer. Cancer research 29 28209614
2022 PA2G4 promotes the metastasis of hepatocellular carcinoma by stabilizing FYN mRNA in a YTHDF2-dependent manner. Cell & bioscience 28 35526051
2016 A polybasic motif in ErbB3-binding protein 1 (EBP1) has key functions in nucleolar localization and polyphosphoinositide interaction. The Biochemical journal 28 27118868
2020 A structural view of PA2G4 isoforms with opposing functions in cancer. The Journal of biological chemistry 26 32952126
2019 Drugging MYCN Oncogenic Signaling through the MYCN-PA2G4 Binding Interface. Cancer research 26 31501192
2001 Regulation of the ErbB3 binding protein Ebp1 by protein kinase C. Molecular and cellular endocrinology 25 11325528
2016 Pa2G4 is a novel Six1 co-factor that is required for neural crest and otic development. Developmental biology 23 27940157
2015 P42 Ebp1 functions as a tumor suppressor in non-small cell lung cancer. BMB reports 23 24998263
1989 Enhancer binding protein (EBP1) makes base and backbone contacts over one complete turn of the DNA double helix. Journal of molecular biology 23 2544731
2010 The ErbB3 binding protein EBP1 regulates ErbB2 protein levels and tamoxifen sensitivity in breast cancer cells. Breast cancer research and treatment 22 20379846
2013 EBP1, a novel host factor involved in primer binding site-dependent restriction of moloney murine leukemia virus in embryonic cells. Journal of virology 20 24227866
2011 EBP1 inhibits translation of androgen receptor mRNA in castration resistant prostate cancer cells. Anticancer research 20 21965718
2007 Ebp1-mediated inhibition of cell growth requires serine 363 phosphorylation. International journal of oncology 20 17786317
2007 Role of host protein Ebp1 in influenza virus growth: intracellular localization of Ebp1 in virus-infected and uninfected cells. Journal of biotechnology 20 17884219
2015 A novel Anxa2-interacting protein Ebp1 inhibits cancer proliferation and invasion by suppressing Anxa2 protein level. Molecular and cellular endocrinology 19 25917452
2013 Regulation of tamoxifen sensitivity by a PAK1-EBP1 signalling pathway in breast cancer. British journal of cancer 19 23361053
2008 Phosphorylation of the ErbB3 binding protein Ebp1 by p21-activated kinase 1 in breast cancer cells. British journal of cancer 19 18283314
2014 Phosphorylation of the N-terminal domain of p48 Ebp1 by CDK2 is required for tumorigenic function of p48. Molecular carcinogenesis 18 25154617
2012 Expression of ERBB3 binding protein 1 (EBP1) in salivary adenoid cystic carcinoma and its clinicopathological relevance. BMC cancer 18 23110497
2022 Loci on chromosome 12q13.2 encompassing ERBB3, PA2G4 and RAB5B are associated with polycystic ovary syndrome. Gene 17 36423778
2021 Dynamic association of human Ebp1 with the ribosome. RNA (New York, N.Y.) 17 33479117
2020 The roles of multifunctional protein ErbB3 binding protein 1 (EBP1) isoforms from development to disease. Experimental & molecular medicine 16 32719408
2011 EBP1 and DRBP76/NF90 binding proteins are included in the major histocompatibility complex class II RNA operon. Nucleic acids research 16 21624892
2015 EBP1 protein modulates the expression of human MHC class II molecules in non-hematopoietic cancer cells. International journal of oncology 15 26081906
2012 ErbB3-binding protein EBP1 decreases ErbB2 levels via a transcriptional mechanism. Oncology reports 15 23242156
2019 Ebp1 p48 promotes oncogenic activities in human colon cancer cells through regulation of TIF-90-mediated ribosomal RNA synthesis. Journal of cellular physiology 14 30793766
2008 Ebp1 expression in benign and malignant prostate. Cancer cell international 14 19025630
2019 Roles of ErbB3-binding protein 1 (EBP1) in embryonic development and gene-silencing control. Proceedings of the National Academy of Sciences of the United States of America 13 31748268
2016 AcEBP1, an ErbB3-Binding Protein (EBP1) from halophyte Atriplex canescens, negatively regulates cell growth and stress responses in Arabidopsis. Plant science : an international journal of experimental plant biology 13 27181948
2010 p48 Ebp1 acts as a downstream mediator of Trk signaling in neurons, contributing neuronal differentiation. Neurochemistry international 13 21145366
2007 Protein kinase C-delta phosphorylates Ebp1 and prevents its proteolytic degradation, enhancing cell survival. Journal of neurochemistry 13 17316401
2022 LINC00987 knockdown inhibits the progression of acute myeloid leukemia by suppressing IGF2BP2-mediated PA2G4 expression. Anti-cancer drugs 12 34407052
2021 HER2-intronic miR-4728-5p facilitates HER2 expression and accelerates cell proliferation and migration by targeting EBP1 in breast cancer. PloS one 12 33529238
2021 EBP1 regulates Suv39H1 stability via the ubiquitin-proteasome system in neural development. BMB reports 12 33691908
2018 ERBB3-Binding Protein 1 (EBP1) Is a Novel Developmental Pluripotency-Associated-4 (DPPA4) Cofactor in Human Pluripotent Cells. Stem cells (Dayton, Ohio) 12 29327467
2017 Neuron-specific expression of p48 Ebp1 during murine brain development and its contribution to CNS axon regeneration. BMB reports 12 27916024
2014 LmaPA2G4, a homolog of human Ebp1, is an essential gene and inhibits cell proliferation in L. major. PLoS neglected tropical diseases 12 24421916
2021 Ebp1 p48 promotes oncogenic properties in hepatocellular carcinoma through p38 MAPK/HIF1α activation and p53 downregulation. Molecular carcinogenesis 11 33634940
2015 ErbB3 binding protein 1 (EBP1) participates in the regulation of intestinal inflammation via mediating Akt signaling pathway. Molecular immunology 11 26256794
2021 Increased PA2G4 Expression Is an Unfavorable Factor in Nasopharyngeal Carcinoma. Applied immunohistochemistry & molecular morphology : AIMM 10 33605574
2016 C-terminal domain of p42 Ebp1 is essential for down regulation of p85 subunit of PI3K, inhibiting tumor growth. Scientific reports 10 27464702
2015 EBP1 suppresses growth, migration, and invasion of thyroid cancer cells through upregulating RASAL expression. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 10 26008146
2007 Expression, purification, crystallization and preliminary crystallographic analysis of the proliferation-associated protein Ebp1. Acta crystallographica. Section F, Structural biology and crystallization communications 10 17768350
2025 The highly conserved PIWI-interacting RNA CRAPIR antagonizes PA2G4-mediated NF110-NF45 disassembly to promote heart regeneration in mice. Nature cardiovascular research 9 39814981
2019 ErbB3-binding protein 1 (EBP1) represses HNF4α-mediated transcription and insulin secretion in pancreatic β-cells. The Journal of biological chemistry 9 31362984
2017 Ebp1 regulates myogenic differentiation of myoblast cells via SMAD2/3 signaling pathway. Development, growth & differentiation 9 28707296
2013 HIV-1 viral protein R downregulates Ebp1 and stabilizes p53 in glioblastoma U87MG cells. Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 9 23828502
2022 Cerebellar dysfunction and schizophrenia-like behavior in Ebp1-deficient mice. Molecular psychiatry 8 35165395
2020 Pseudogene PA2G4P4 promotes oncogene PA2G4 expression and nuclear translocation to affect glioblastoma cell viability and apoptosis. Life sciences 8 33220287
2014 Upregulated expression of ebp1 contributes to schwann cell differentiation and migration after sciatic nerve crush. Journal of molecular neuroscience : MN 8 24878627
2023 LINC00173 facilitates tumor progression by stimulating RAB1B-mediated PA2G4 and SDF4 secretion in nasopharyngeal carcinoma. Molecular oncology 7 36606322
2019 YC-1 Antagonizes Wnt/β-Catenin Signaling Through the EBP1 p42 Isoform in Hepatocellular Carcinoma. Cancers 7 31086087
2019 Somatic Mutations and Intratumoral Heterogeneity of Cancer-Related Genes NLK, YY1 and PA2G4 in Gastric and Colorectal Cancers. Pathology oncology research : POR 7 31828582
2014 Androgen receptor (AR) inhibitor ErbB3-binding protein-1 (Ebp1) is not targeted by the newly identified AR controlling signaling axis heat-shock protein HSP27 and microRNA miR-1 in prostate cancer cells. World journal of urology 7 24798454
2020 Dysregulation of Epigenetic Control Contributes to Schizophrenia-Like Behavior in Ebp1+/- Mice. International journal of molecular sciences 6 32283721
2015 The ErbB3-binding protein EBP1 modulates lapatinib sensitivity in prostate cancer cells. Molecular and cellular biochemistry 6 25876877
2013 Expression of ErbB3-binding protein-1 (EBP1) during primordial follicle formation: role of estradiol-17ß. PloS one 6 23840586
2010 EBP1 is a novel E2F target gene regulated by transforming growth factor-β. PloS one 6 21085677
2021 The GpIA7 effector from the potato cyst nematode Globodera pallida targets potato EBP1 and interferes with the plant cell cycle programme. Journal of experimental botany 5 34310681