Affinage

SIN3A

Paired amphipathic helix protein Sin3a · UniProt Q96ST3

Length
1273 aa
Mass
145.2 kDa
Annotated
2026-06-10
100 papers in source corpus 59 papers cited in narrative 59 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

SIN3A is an evolutionarily conserved scaffold that nucleates a histone deacetylase (HDAC1/2) co-repressor complex and is recruited to specific promoters by a wide array of sequence-specific transcription factors and adaptors, where it enforces histone deacetylation and transcriptional silencing (PMID:10491605, PMID:22101514, PMID:24763403). Recruitment occurs through SIN3A's paired amphipathic helix (PAH) domains, which serve as modular docking platforms: PAH2 binds the SIN3-interaction domains of Mad/Mxi1-family and KLF repressors and the PF1/PHF12 adaptor (PMID:16813833, PMID:26460951, PMID:8649810), PAH3/HID binds MBD2b and the constitutively associated SAP30/SAP30L subunits—the latter targeting the complex to the nucleolus—with the PAH3–SAP30 interface defined at atomic resolution by NMR (PMID:10950960, PMID:21676866, PMID:16820529), and PAH1 docks Tet1 via a conserved SID whose interface residues are required for function (PMID:29733394, PMID:30279502). Through these contacts SIN3A is delivered to chromatin by repressors and adaptors including Snail, REST, PSF, Ebp1, TGIF, Alien/HCR, BMP-Smad effectors, Gon4l, Mohawk, and MeCP2, and its targeting and release are controlled by post-translational events on its partners, such as PRMT1 methylation of RUNX1 that abolishes SIN3A binding and PKCα/ERK-driven Sp1 phosphorylation that evicts the complex from promoters (PMID:14673164, PMID:10491605, PMID:11259580, PMID:18316480, PMID:18372343). SIN3A also deacetylates non-histone substrates including c-Myc and STAT3, forming negative-feedback circuits that restrain their activity (PMID:22101514, PMID:22783022). Paradoxically, SIN3A functions as a co-activator when partnered with Tet1/Tet2, promoting promoter DNA demethylation/hydroxymethylation to activate target genes and to support ESC pluripotency and reprogramming (PMID:29733394, PMID:37456851, PMID:35073971). Beyond transcription, the SIN3A–HDAC complex maintains genome integrity: it suppresses co-transcriptional R-loops through physical interaction with the THO/TREX complex and protects stalled replication forks from MUS81-mediated cleavage by keeping nascent chromatin deacetylated (PMID:29074626, PMID:38341854). SIN3A is essential in vivo for pluripotent-cell genomic integrity, hematopoietic stem cell homeostasis, spermatogenesis, lung endoderm specification, β-cell function, and neuronal plasticity and memory (PMID:22206758, PMID:24763403, PMID:22820070, PMID:28619823, PMID:32245798, PMID:32069266).

Mechanistic history

Synthesis pass · year-by-year structured walk · 15 steps
  1. 1996 Medium

    Established that a transcriptional repressor's silencing activity can be reduced to its capacity to recruit SIN3A, defining SIN3A as the functional repression module downstream of Mad/Mxi1 factors.

    Evidence Co-IP and fusion-protein repression/transformation assays with Mxi1 in mouse cells

    PMID:8649810

    Open questions at the time
    • Did not resolve how SIN3A connects to deacetylase enzymatic activity
    • Single repressor system
  2. 1999 High

    Showed SIN3A links DNA-bound repressors to HDAC activity at native gene promoters, providing the first promoter-level mechanism for RE1/NRSE silencing of neuronal genes.

    Evidence Co-IP, reporter and promoter occupancy assays with REST on GluR2 and sodium channel genes

    PMID:10491605

    Open questions at the time
    • Domain of SIN3A engaged by REST not mapped
    • HDAC catalytic dependence inferred pharmacologically
  3. 2000 Medium

    Identified the PAH domains as discrete partner-docking surfaces, mapping methyl-CpG reader MBD2b to PAH3.

    Evidence GST pulldown, Co-IP, deletion mapping

    PMID:10950960

    Open questions at the time
    • No structural detail of the interface
    • Single adaptor
  4. 2003 Low

    Defined PAH2 as a selectively recognized interface with distinct SID binding modes, explaining how different repressor classes are differentially recruited.

    Evidence Computational modeling plus binding assays of Mad-family and KLF SIDs

    PMID:12885416

    Open questions at the time
    • Primarily computational with limited experimental binding data
    • No high-resolution complex structure
  5. 2004 High

    Extended SIN3A recruitment to developmental and EMT contexts, showing Snail and BMP-Smad/Dach1 effectors deliver the HDAC–SIN3A complex to target promoters.

    Evidence Co-IP, ChIP, TSA inhibition (Snail/E-cadherin) and in vivo limb assays (Dach1/Smad)

    PMID:14673164 PMID:15280207

    Open questions at the time
    • Promoter-specificity determinants not defined
    • Interface mapping on SIN3A absent
  6. 2006 Medium

    Mapped the SAP30/SAP30L constitutive subunits to the PAH3/HID region and showed they direct SIN3A to the nucleolus, linking the complex to rRNA-gene loci.

    Evidence Co-IP, deletion mapping, NLS analysis, localization imaging and biophysical NMR/AUC of PAH2

    PMID:16813833 PMID:16820529

    Open questions at the time
    • Functional consequences at rDNA not directly demonstrated
    • Paralog-specific PAH2 behavior of unclear in vivo relevance
  7. 2008 High

    Demonstrated that post-translational modification of SIN3A partners acts as a switch controlling complex assembly and promoter occupancy.

    Evidence Mass spectrometry, methyl-arginine antibodies, Co-IP/ChIP (PRMT1–RUNX1) and ChIP/Co-IP with kinase inhibition (Sp1)

    PMID:18316480 PMID:18372343

    Open questions at the time
    • Whether SIN3A itself is modified not addressed
    • Generalizability across other partners untested
  8. 2011 High

    Revealed atomic-resolution recognition (PAH3–SAP30 SID) and established SIN3A as a deacetylase of non-histone substrates with tumor-suppressive feedback roles.

    Evidence NMR solution structure with nucleic-acid binding; conditional KO, ChIP, Co-IP and double-KO epistasis (c-Myc)

    PMID:21676866 PMID:22101514

    Open questions at the time
    • How non-histone deacetylation is targeted in vivo unclear
    • Structures of other PAH–SID complexes lacking
  9. 2011 High

    Established SIN3A as essential for genomic integrity of pluripotent cells, connecting transcriptional control to DNA damage avoidance.

    Evidence Conditional KO mouse and ES-cell deletion with γH2AX, cell-cycle and expression profiling

    PMID:22206758

    Open questions at the time
    • Direct molecular link between SIN3A loss and DSB formation not resolved
    • Distinguishing transcriptional vs. replicative cause
  10. 2012 High

    Defined SIN3A as a context-dependent signaling switch that deacetylates STAT3 and gates interferon/STAT transcriptional output.

    Evidence Genome-wide RNAi screen, Co-IP, ChIP, siRNA

    PMID:22783022

    Open questions at the time
    • Mechanism of substrate selection (STAT3 vs ISGF3 components) unclear
    • Direct vs indirect deacetylation
  11. 2017 High

    Connected the SIN3A–HDAC complex to genome stability via the THO/TREX complex, showing it suppresses co-transcriptional R-loops by maintaining deacetylation.

    Evidence Reciprocal Co-IP, siRNA, DRIP, immunofluorescence, replication fork assays

    PMID:29074626

    Open questions at the time
    • How deacetylation mechanistically prevents R-loops not resolved
    • Direct THO subunit contact on SIN3A not mapped
  12. 2017 High

    Identified compositionally distinct, lineage-specialized SIN3A complexes (FAM60A/SINHCAF-containing) that incorporate OGT/Tet1 and target H3K4me3 promoters and the hypoxia response.

    Evidence Tandem endogenous IP with quantitative MS, ChIP-seq, siRNA phenocopy; Co-IP/ChIP for HIF-2α

    PMID:28554894 PMID:29784889

    Open questions at the time
    • Full catalog of variant complexes incomplete
    • How FAM60A retains the complex on chromatin mechanistically unclear
  13. 2018 High

    Resolved the PAH1–Tet1 SID interface and established a co-activator mode of SIN3A in which Tet1/2 partnership promotes DNA demethylation to activate genes and sustain pluripotency.

    Evidence NMR, mutagenesis of interface residues, Co-IP, ChIP-seq, MeDIP-seq, reporter assays

    PMID:29733394 PMID:30279502

    Open questions at the time
    • How a single scaffold toggles between repressive and activating output unclear
    • Catalytic-independent Tet recruitment mechanism only partly defined
  14. 2020 High

    Demonstrated tissue-level physiological requirements for SIN3A in β-cell function and in hippocampal synaptic plasticity and memory, linking the scaffold to specific direct target programs.

    Evidence Conditional KO mice with RNA-seq, ChIP, calcium imaging/insulin secretion (β-cell); electrophysiology, behavior, ChIP (neuronal)

    PMID:32069266 PMID:32245798

    Open questions at the time
    • Which partner factors recruit SIN3A to these tissue-specific targets unknown
    • Causal HDAC-substrate links per phenotype not fully dissected
  15. 2024 High

    Established a direct replication-fork-protective role for SIN3A-complex deacetylase activity, shielding stalled forks from MUS81 cleavage by keeping nascent chromatin deacetylated.

    Evidence iPOND, ChIP, DNA fiber assays, siRNA, MUS81 co-depletion epistasis

    PMID:38341854

    Open questions at the time
    • How SIN3A is recruited specifically to stalled forks unclear
    • Relationship to its transcriptional role at the same loci undefined

Open questions

Synthesis pass · forward-looking unresolved questions
  • It remains unresolved what molecular logic determines whether SIN3A acts as a repressor versus a Tet-dependent co-activator at a given locus, and how the scaffold integrates its transcriptional, R-loop-suppressing, and fork-protective activities.
  • No unifying model for repressor-to-coactivator switching
  • Determinants of variant-complex assembly across cell types incomplete
  • Structural basis of full PAH-domain partner selectivity not comprehensively defined

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060090 molecular adaptor activity 4 GO:0140110 transcription regulator activity 4 GO:0098772 molecular function regulator activity 3 GO:0140096 catalytic activity, acting on a protein 2
Localization
GO:0005634 nucleus 3 GO:0005730 nucleolus 2
Pathway
R-HSA-1266738 Developmental Biology 4 R-HSA-162582 Signal Transduction 3 R-HSA-4839726 Chromatin organization 3 R-HSA-73894 DNA Repair 3 R-HSA-74160 Gene expression (Transcription) 3
Partners
FAM60AHDAC1HDAC2LSD1MECP2SAP30STAT3TET1
Complex memberships
FAM60A/SINHCAF variant Sin3A-HDAC complex (with OGT, Tet1)SIN3A-HDAC1/2 co-repressor complexTHO/TREX complex (physical partner)

Evidence

Reading pass · 59 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2004 Snail mediates E-cadherin repression by recruiting a complex containing HDAC1, HDAC2, and mSin3A via its SNAG domain; this interaction is SNAG domain-dependent and results in histone H3/H4 deacetylation at the E-cadherin promoter. Co-immunoprecipitation, ChIP, TSA inhibitor experiments, overexpression studies Molecular and cellular biology High 14673164
1999 The N-terminal repression domain of REST recruits Sin3A and histone deacetylase to neuronal gene promoters (GluR2 and type II sodium channel) in nonneuronal cells, establishing a mechanism for RE1/NRSE-mediated silencing. Multiple co-immunoprecipitation, reporter assay, ChIP-like promoter analysis Nature neuroscience High 10491605
2008 PRMT1 methylates RUNX1 at arginine residues R206 and R210, which lie within the SIN3A-interaction region of RUNX1; this methylation abrogates RUNX1-SIN3A association, converting RUNX1 from a repressor to an activator. shRNA against PRMT1 enhances RUNX1-SIN3A association. Mass spectrometry, methyl-arginine-specific antibody, Co-IP, shRNA knockdown, ChIP Genes & development High 18316480
2001 PSF (polypyrimidine tract-binding protein-associated splicing factor) acts as a corepressor by interacting with Sin3A and mediating silencing through recruitment of HDACs to the DNA-binding domains of nuclear hormone receptors TR and RXR, independently of N-CoR/SMRT. Biochemical pulldown, Co-immunoprecipitation, in vivo transcription assays Molecular and cellular biology Medium 11259580
2017 Human THO complex physically interacts with the Sin3A histone deacetylase complex; this interaction suppresses co-transcriptional R-loop formation, DNA damage, and replication impairment. Depletion of either THO or Sin3A leads to histone hypo-acetylation, increased R-loop accumulation, and genomic instability. Co-immunoprecipitation, siRNA knockdown, immunofluorescence, DNA-RNA hybrid detection (DRIP), replication fork assays The EMBO journal High 29074626
2003 Nkx3.2 forms an in vivo complex with HDAC1 and Smad1/Smad4 in a BMP-dependent manner; recruitment of the HDAC/Sin3A complex to Nkx3.2 requires Smad1/4 interaction, establishing that BMP-Smads potentiate transcriptional repression through Sin3A. Co-immunoprecipitation, reporter assay, dominant-negative Smad4 cell line rescue Molecular and cellular biology Medium 14612411
2000 MBD2b binds directly to Sin3A; the minimal repression domain of MBD2b overlaps with its methyl-CpG-binding domain, and the interaction domain on Sin3A is the paired amphipathic helix 3 (PAH3) region. GST pulldown, co-immunoprecipitation, deletion mapping The Journal of biological chemistry Medium 10950960
2013 EBNA3C physically interacts with Sin3A and recruits it to the CDKN2A (p14ARF) promoter through BATF/IRF4/SPI1/RUNX3 composite sites; conditional EBNA3C inactivation significantly decreased Sin3A binding at the p14ARF promoter, establishing Sin3A-mediated repression of p14ARF and p16INK4A. ChIP-seq, Co-immunoprecipitation, conditional inactivation Proceedings of the National Academy of Sciences of the United States of America Medium 24344258
2018 SIN3A binds to promoters of hypoxia-repressed genes prior to hypoxia and participates in downregulation of 75% of hypoxia-repressed genes and induction of 47% of upregulated genes in endothelial cells; SIN3A occupancy is not altered by hypoxia itself but modulation of associated HDAC activity determines transcriptional output. siRNA knockdown, ChIP-seq, nascent RNA sequencing (4-thiouridine labeling) Nucleic acids research Medium 29059365
2009 Estrogen-bound ERα recruits Sin3A to the proximal A promoter of ESR1, leading to loss of RNA polymerase II and repression; a direct estrogen-responsive interaction between Sin3A and ERα was identified; Sin3A siRNA knockdown specifically inhibits estrogen-induced repression of ESR1. ChIP, Co-immunoprecipitation, siRNA knockdown Molecular and cellular biology Medium 19620290
2012 Sin3A directly interacts with STAT3, promotes STAT3 deacetylation, and is required for ISGF3-dependent (STAT1:STAT2:IRF9) gene transcription; Sin3A silencing results in prolonged nuclear retention of activated STAT3, enhanced STAT3 recruitment to the SOCS3 promoter, histone hyperacetylation, and enhanced STAT3-dependent transcription. Sin3A acts as a context-dependent ISGF3/STAT3 transcriptional switch. Genome-wide RNAi screen, Co-immunoprecipitation, ChIP, siRNA knockdown Proceedings of the National Academy of Sciences of the United States of America High 22783022
2016 MeCP2 interacts with SIN3A; haploinsufficiency of SIN3A in vivo causes reduced cortical neurogenesis, altered neuronal identity, and aberrant corticocortical projections in the developing mouse brain following knockdown. In vivo functional knockdown (mouse), immunofluorescence, neuronal projection analysis Nature genetics Medium 27399968
2005 Ebp1 interacts directly with Sin3A (C-terminal domain of Ebp1 with PAH4/HID domain of Sin3A); both Ebp1 and Sin3A co-occupy the PSA and E2F1 promoters; Sin3A enhances Ebp1-mediated repression of androgen receptor and E2F1-regulated genes. GST pulldown, Co-immunoprecipitation, ChIP, reporter assay Nucleic acids research Medium 16254079
2004 Only a small, unstable fraction of MeCP2 interacts with Sin3A; purified rat brain MeCP2 behaves as an elongated monomer (~53 kDa) with no stably associated proteins, indicating MeCP2 is not an obligate Sin3A complex component. Size-exclusion chromatography, biophysical analysis (sedimentation), Co-immunoprecipitation from multiple tissues The Journal of biological chemistry Medium 15322089
2007 AHPN/3-Cl-AHPC binds to the orphan nuclear receptor SHP, promoting SHP interaction with a corepressor complex containing Sin3A, N-CoR, HDAC4, and HSP90; formation of the SHP-Sin3A complex is essential for AHPN/3-Cl-AHPC-induced apoptosis, as SHP knockout or Sin3A knockdown compromises proapoptotic activity. Ligand-binding assay, Co-immunoprecipitation, siRNA/KO knockdown, apoptosis assay Cancer research Medium 17210713
2011 The NMR solution structure of the mSin3A PAH3 domain complexed with the SAP30 Sin3-interaction domain (SID) was determined; PAH3 adopts a left-handed four-helix bundle; SAP30 SID binds via a tripartite motif to an interface of ~1400 Ų, accounting for constitutive association. The PAH3-SAP30 SID complex can bind nucleic acids, suggesting a role in targeting the complex to ribosomal RNA genes. NMR spectroscopy, solution structure determination, nucleic acid binding assays The Journal of biological chemistry High 21676866
2006 SAP30L binds to the PAH3/HID region of Sin3A via residues 120–140, recruits Sin3A to the nucleolus via a functional nucleolar localization signal, and induces transcriptional repression; SAP30 also targets Sin3A to the nucleolus. Co-immunoprecipitation, deletion mapping, reporter assay, subcellular localization imaging Nucleic acids research Medium 16820529
2004 The highly conserved region (HCR) of Sin3A, spanning ~134 amino acids and sharing >80% identity with Sin3B, interacts with the N-terminus of the corepressor Alien; this interaction is demonstrated both in vivo by ChIP (at the CYP24 promoter) and in vitro; HCR overexpression inhibits Alien-mediated repression and induces endogenous CYP24 expression. Co-immunoprecipitation, ChIP, reporter assay, GST pulldown Nucleic acids research Medium 15173382
2003 The SIN3 interaction domain (SID) of Mad-family repressors and KLF proteins bind differentially to the PAH2 domain of Sin3A; computational and experimental analyses show two SID subtypes exhibit distinct PAH2 binding modes, providing structural insight into selective corepressor recruitment. Computational modeling, binding assays FEBS letters Low 12885416
2006 The apo PAH2 domain of mSin3A is monomeric and folded at low micromolar concentrations but dimerizes at higher concentrations with concomitant partial unfolding, in contrast to mSin3B PAH2 behavior, suggesting paralog-specific structural differences relevant to coregulator interactions. NMR spectroscopy, analytical ultracentrifugation, biophysical analysis Journal of molecular biology Medium 16813833
2011 Sin3A interacts with c-Myc and causes deacetylation of c-Myc protein, directly repressing c-Myc activity; in the absence of Sin3A, c-Myc genomic recruitment to the epidermal differentiation complex is enhanced; simultaneous deletion of c-Myc and Sin3A reverts the aberrant skin phenotype, establishing a negative feedback loop. Conditional knockout mouse, ChIP, Co-immunoprecipitation, epistasis (double knockout rescue) Nature cell biology High 22101514
2011 Sin3a-null embryos suffer unresolved DNA damage and acute apoptosis specifically in the epiblast; Myc and E2F targets are downregulated in Sin3a-null ICMs; ES cells deleted for Sin3a show DNA double-strand break response, G2 arrest, and apoptosis, establishing Sin3a as essential for genomic integrity of pluripotent cells. Conditional knockout mouse, ES cell deletion, γH2AX staining, cell cycle analysis, gene expression profiling Developmental biology High 22206758
2017 FOXN3 is physically associated with the SIN3A repressor complex in ER+ cells; the lncRNA NEAT1 is required for FOXN3 interactions with the SIN3A complex (shown by RNA immunoprecipitation); the FOXN3-NEAT1-SIN3A complex represses GATA3 and ER (ESR1) genes, forming a negative-feedback loop; NEAT1 is identified as a facultative component of the SIN3A complex. RNA immunoprecipitation-sequencing, ChIP-seq, Co-immunoprecipitation, in vitro/in vivo functional studies The Journal of clinical investigation High 28805661
2018 LSD1 is an integral component of the SIN3A/HDAC complex; the LSD1/SIN3A/HDAC complex co-targets genes in p53 signaling and other pathways as shown by ChIP-on-chip; LSD1 and SIN3A coordinate to inhibit genes including CASP7, TGFB2, CDKN1A, HIF1A, TERT, and MDM2. Co-immunoprecipitation, ChIP-on-chip, siRNA knockdown Journal of molecular cell biology Medium 29741645
2018 Sin3a interacts with Tet1 via a highly conserved SID in the PAH1 domain; two residues (Phe147, Phe182) in PAH1 are essential for Sin3a-Tet1 interaction; Sin3a-Tet1 complex activates transcription of Lefty1 and other target genes by promoting promoter DNA demethylation; this activity is required for ESC pluripotency. NMR spectroscopy, co-immunoprecipitation, ChIP-seq, MeDIP-seq, site-directed mutagenesis, reporter assay Nucleic acids research High 29733394
2018 Tet1 contains a conserved SID that inserts into the PAH1 domain of Sin3A in a Type-II orientation similar to Sap25; mutagenesis of key SID residues abolishes the interaction and is absolutely required for Tet1 to repress transcription in cells. NMR spectroscopy, homology modelling, mutagenesis, Co-immunoprecipitation, transcription reporter assay Scientific reports High 30279502
2014 CRL4B (CUL4B-containing ubiquitin ligase) physically interacts with the SIN3A-HDAC complex and co-occupies CDKN1A and CDKN1C promoters; CUL4B loss reduces SIN3A-HDAC retention on promoters, increases histone acetylation, and upregulates p21 and p57; the ubiquitylation function of CRL4B is not required for stable SIN3A-HDAC retention. Co-immunoprecipitation, ChIP, siRNA knockdown, histone acetylation assays Journal of cell science Medium 25189618
2017 Sin3a is required for Sin3A/HDAC2 complex function in lung endoderm; loss of Sin3a in mouse early foregut endoderm causes embryonic lung epithelial progenitor cells to adopt a senescence-like state with permanent G1 arrest, mediated at least partially through upregulation of Cdkn1a and Cdkn2c; loss also disrupts epithelial-mesenchymal signaling. Conditional knockout mouse, cell cycle analysis, gene expression profiling Development (Cambridge, England) Medium 28619823
2010 Sertoli cell-specific deletion of Sin3a reduces undifferentiated spermatogonia (Plzf, Gfra1, Oct4 markers downregulated), disrupts CXCL12/SDF1 and CXCR4 signaling, causes progressive spermatogenic failure, and suppresses teratoma formation from fetal germ cells in transplantation assays, establishing a non-cell-autonomous epigenetic role for Sin3a in niche function. Conditional knockout mouse (Sertoli-specific), marker analysis, transplantation assay Stem cells (Dayton, Ohio) Medium 20572009
2014 Sin3a-associated Hdac1 and Hdac2 control hematopoietic stem cell homeostasis cell-autonomously; bone-marrow-specific deletion of Sin3a phenocopies loss of Hdac1/2, causing bone marrow failure, establishing that Sin3a-associated HDAC1/2 activity is essential for HSC homeostasis. Conditional knockout mouse (bone marrow specific), HSPC analysis, phenotypic rescue Haematologica Medium 24763403
2011 Gon4l interacts with YY1, Sin3a, and HDAC1 as components of a single complex in mouse B cells (demonstrated by sequential immunoprecipitation); a conserved central domain of Gon4l is required for this complex assembly; Gon4l represses promoter activity in a manner correlated with its ability to interact with Sin3a and HDAC1. Co-immunoprecipitation, sequential immunoprecipitation, density gradient sedimentation, reporter assay The Journal of biological chemistry Medium 21454521
2009 Mohawk recruits components of the Sin3A/HDAC co-repressor complex (Sin3A, Hdac1, Sap18) and a subset of general transcription factors; MRD1 (one of three repressor domains in Mohawk) is co-immunoprecipitated by Sap18; Mohawk represses target genes required for myogenic differentiation through this mechanism. Co-immunoprecipitation, point mutation analysis, reporter assay Developmental dynamics Medium 19235719
2008 T-bet-dependent removal of HDAC-Sin3A complexes from the Ifng locus drives H4 acetylation accumulation and Th1 differentiation; in Th0 cells, HDAC-Sin3A complexes actively prevent H4 acetylation; loss of HDAC-Sin3A occurs during Th1 lineage commitment through T-bet-dependent mechanisms. ChIP, T-bet genetic analysis, Th1/Th0 differentiation assays Journal of immunology Medium 19050254
2010 Sumoylation of ING2 at lysine 195 by SUMO1 enhances its association with Sin3a; sumoylated ING2 is required for Sin3A/HDAC complex recruitment to target gene promoters (e.g., TMEM71) and for regulation of their transcription. In vitro sumoylation assay, Co-immunoprecipitation, ChIP, reporter assay Oncogene Medium 20676127
2008 PKCα/ERK signaling causes Sp1 phosphorylation, which leads to dissociation of the HDAC1/mSin3A repressor complex from Sp1 binding sites on the LHR promoter, histone H3 acetylation, and derepression of LHR transcription. Co-immunoprecipitation, ChIP, kinase inhibition, dominant-negative overexpression Molecular endocrinology Medium 18372343
2001 TGIF directly interacts with Sin3A, thereby recruiting HDAC1 to androgen receptor (AR)-responsive promoters to repress AR-mediated transcription; this repression is TSA-sensitive and TGIF binds the DNA-binding domain of AR. Co-immunoprecipitation, reporter assay, TSA inhibition Molecular endocrinology Medium 11682623
2019 STAT3 is constitutively acetylated in NPM-ALK+ ALCL cells; acetylated STAT3 constitutively binds the Sin3A complex and together occupies promoters of silenced tumor suppressor genes; SIN3A silencing causes re-expression of TSGs and induces ALCL apoptosis in vitro and reduces tumorigenic potential in vivo. STAT3-Sin3A association was also found in breast adenocarcinoma cells. Co-immunoprecipitation, ChIP, siRNA knockdown, in vivo xenograft, resveratrol pharmacology Cancer research Medium 30692217
2017 ARID1A directly causes suppression of TERT expression and co-occupies the TERT promoter with the SIN3A repressor complex during retinoic acid-induced neuroblastoma differentiation; SIN3A co-occupancy is required for ARID1A-dependent TERT repression. ChIP-qPCR, TERT expression analysis, telomeric repeat amplification protocol, immunoblot Molecular carcinogenesis Medium 31365169
2014 SIN3A is required for transcriptional induction of CYP1A1 by TCDD (aryl hydrocarbon receptor ligand); TCDD treatment increases SIN3A binding to both the proximal promoter and enhancer of Cyp1a1; ectopic human SIN3A rescues TCDD-induced EROD activity in Sin3A-depleted cells, establishing a positive (activating) role for SIN3A at an AhR target gene. siRNA knockdown, ectopic expression rescue, ChIP, EROD enzyme assay The Journal of biological chemistry Medium 25305016
2017 Fam60a defines a variant Sin3a-Hdac complex present in ES cells that additionally contains Ogt and Tet1; Fam60a is essential for maintaining the complex on chromatin at H3K4me3-positive promoters; depletion of Fam60a phenocopies loss of Sin3a (reduced proliferation, extended G1, deregulation of lineage genes). Tandem endogenous immunoprecipitation with quantitative mass spectrometry, ChIP-seq, siRNA knockdown, phenotypic analysis The EMBO journal High 28554894
2018 The HDAC2/Sin3A/MeCP2 corepressor complex acts as an endogenous inhibitor of CTGF at the CTGF promoter; ET-1 disrupts this complex through MAP kinase-mediated HDAC2 phosphorylation, releasing HDAC2/Sin3A/MeCP2 from the CTGF promoter and allowing AP-1-driven CTGF expression. Co-immunoprecipitation, ChIP, siRNA knockdown, overexpression, kinase inhibitors Journal of biomedical science Medium 37312162
2017 HDAC2 and cofactor Sin3A deacetylate histones H3K14ac and H3K27ac at the ASS1 promoter during arginine starvation, facilitating PHD2-driven HIF-1α proteasomal degradation at the promoter and enabling ASS1 derepression. ChIP, Co-immunoprecipitation, knockdown, proteasome inhibitor studies Scientific reports Medium 28883660
2020 Sin3A regulates hippocampal synaptic plasticity and long-term memory: postnatal neuronal deletion of Sin3a enhances hippocampal LTP and contextual fear memory; Sin3A loss increases Homer1 expression, alters mGluR1α and mGluR5 dependence of LTP, and increases ERK activation after learning. Conditional knockout mouse, electrophysiology (LTP), fear conditioning, ChIP, gene expression analysis JCI insight High 32069266
2024 SIN3A complex histone deacetylase activity protects stalled replication forks from MUS81 endonuclease-mediated cleavage; Sin3A is enriched at replicating DNA under hydroxyurea treatment; Sin3A-depleted cells show increased replication fork stalling, H3 acetylation at stalled forks, MRE11-dependent DNA degradation, and impaired fork recovery—effects partially dependent on MUS81. iPOND (isolation of proteins on nascent DNA), ChIP, DNA fiber assays, siRNA knockdown, genetic epistasis (MUS81 co-depletion) Cell reports High 38341854
2023 Nuclear complement C3b physically associates with the HDAC1/2-containing SIN3A complex; this interaction enhances SIN3A complex binding to the GADD45A promoter, reducing H3 acetylation and repressing GADD45A expression, thereby promoting paclitaxel resistance in NSCLC. Co-immunoprecipitation, ChIP, nuclear fractionation, siRNA knockdown, ectopic expression Cell death & disease Medium 37291119
2019 Sin3a regulates the developmental progression through the morula-to-blastocyst transition via Hdac1: Sin3a depletion increases Trp53 acetylation (K379), reduces Cdx2 and Nanog, causes global DNA hypermethylation via increased nuclear DNMT1, and downregulates Hdac1; exogenous Hdac1 but not Hdac2 rescues the block. siRNA knockdown in mouse embryos, RNA-seq, Western blot, immunofluorescence, rescue by Hdac1 mRNA injection FASEB journal Medium 31450981
2023 Tet2 recruits Sin3a to active enhancers in ESCs; Tet2 deficiency diminishes Sin3a at active enhancers and promoters; combined Tet1/2 loss (but not loss of their catalytic activities alone) reduces Sin3a at active enhancers, showing that Tet1/2 noncatalytic functions recruit Sin3a. ChIP-seq, Tet2 catalytic mutant and KO ESCs, Co-immunoprecipitation iScience Medium 37456851
2018 SINHCAF/FAM60A links the SIN3A-HDAC complex to the hypoxia response by specifically repressing HIF-2α mRNA and protein expression; SINHCAF interacts with SP1 and recruits HDAC1 to the HIF-2α promoter to mediate this repression. Co-immunoprecipitation, ChIP, siRNA knockdown, angiogenesis assays The Biochemical journal Medium 29784889
2015 Disruption of the SIN3A PAH2 domain interaction with PF1 (PHF12/SID-containing adaptor) using a competitive Tat-SID peptide blocks EMT and stem cell marker expression in TNBC; KLF9 is recruited to ITGA6 and ITGB1 promoters by SIN3A and mediates their repression; KLF9 knockdown re-establishes invasion. Peptide competition (Tat-SID), Co-immunoprecipitation, ChIP, siRNA knockdown, in vitro and in vivo invasion assays Oncotarget Medium 26460951
2013 BIM is epigenetically silenced in NPM/ALK+ ALCL through recruitment of MeCP2 and the SIN3a/HDAC1/2 corepressor complex to the BIM locus; CpG methylation is required for MeCP2 corepressor complex recruitment; demethylation with 5-azacytidine detaches the complex and reacetylates histone tails. ChIP, DNA methylation analysis (5-azacytidine treatment), histone acetylation assays, siRNA knockdown Neoplasia (New York, N.Y.) Medium 23633923
2011 Sin3A couples with MeCP2 at the GFAP promoter to suppress GFAP transcription; upon astrocyte differentiation, Sin3A-MeCP2 depart from the promoter coincident with STAT3 binding, CBP/p300 recruitment, and histone H3K9/K14 acetylation that drives GFAP expression. ChIP, immunofluorescence, siRNA knockdown, reporter assay PloS one Medium 21779366
2022 Sin3A functions as a transcriptional coactivator cooperating with Tet1 to facilitate hydroxymethylation of epithelial gene promoters; disrupting the Sin3a-Tet1 interaction (via PAH1 mutants) significantly blocks mesenchymal-to-epithelial transition and iPSC generation. Co-immunoprecipitation, ChIP, hydroxymethylated DNA immunoprecipitation (hMeDIP), site-directed mutagenesis, RNA-seq Stem cell research & therapy Medium 35073971
2020 SIN3A loss in pancreatic β-cells compromises survival, insulin-vesicle packaging, insulin secretion, and nutrient-induced Ca2+ influx; ChIP assays identify direct Sin3a target genes in β-cells modulating Ca2+/ion transport, cell survival, vesicle trafficking, and glucose metabolism. Conditional knockout mouse (endocrine progenitor), RNA-seq, ChIP, calcium imaging, insulin secretion assays Diabetes High 32245798
2021 SIN3A depletion in porcine early embryos reduces CCNB1 (Cyclin B1) transcript levels and causes two-cell stage arrest; injection of CCNB1 mRNA partially rescues SIN3A-depleted embryos, establishing SIN3A regulation of CCNB1 as a key mechanism in porcine embryonic development. siRNA knockdown, RNA-seq, mRNA rescue injection, immunofluorescence Frontiers in cell and developmental biology Medium 33692994
2023 Sin3A-deficient CD4+ T cells fail to properly upregulate Il17a, Il23r, and Il22 under Th17 skewing conditions; instead, IL-2+ and FOXP3+ cells accumulate; Sin3A deletion causes overt STAT3 activation, aberrant cytoplasmic RORγt accumulation, and enrichment of mTORC1 signaling genes. Conditional knockout mouse (CD4-Cre), flow cytometry, cytokine assays, gene expression analysis EMBO reports Medium 36929576
1996 Mouse Sin3A physically associates with the strong repressive isoform of Mxi1 (Mxi1-SR); a mSin3A-Mxi1 fusion protein in which the mSin3-interacting domain of Mxi1 is replaced by full-length mSin3A exhibits repression equivalent to Mxi1-SR, demonstrating that the Mxi1 N-terminal repression domain functions solely to recruit mSin3A. Co-immunoprecipitation, fusion protein repression assay, transformation assay Oncogene Medium 8649810
2004 Chick Dach1 interacts with the Smad complex and the corepressor Sin3a, acting as a repressor of BMP-mediated transcriptional control; this interaction regulates apical ectodermal ridge formation and proximodistal patterning in the limb. Co-immunoprecipitation, in vivo limb functional assays Development (Cambridge, England) Medium 15280207
2012 Sin3a is required in the male germline for mitotic reentry of gonocytes; germline genetic inactivation of Sin3a causes rapid depletion of gonocytes coincident with cell cycle reentry, 2.5-fold increased histone H3 phosphorylation, prophase/metaphase block, near-complete germ cell loss, and altered Sertoli cell expression programs. Conditional knockout mouse (germline), histone phosphorylation analysis, gene expression profiling Developmental biology Medium 22820070
2021 ZBTB25 and Sin3A associate with the HDAC1 silencing complex and are recruited to the IL-12B promoter in M. tuberculosis-infected macrophages to downregulate IL-12B expression; ZBTB25 knockdown prevents complex recruitment and enhances IL-12p40 release. Co-immunoprecipitation, ChIP, siRNA knockdown, cytokine assays mSphere Medium 33627504

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2004 Snail mediates E-cadherin repression by the recruitment of the Sin3A/histone deacetylase 1 (HDAC1)/HDAC2 complex. Molecular and cellular biology 605 14673164
1999 Transcriptional repression by REST: recruitment of Sin3A and histone deacetylase to neuronal genes. Nature neuroscience 343 10491605
2017 The FOXN3-NEAT1-SIN3A repressor complex promotes progression of hormonally responsive breast cancer. The Journal of clinical investigation 170 28805661
2008 Methylation of RUNX1 by PRMT1 abrogates SIN3A binding and potentiates its transcriptional activity. Genes & development 158 18316480
2001 PSF is a novel corepressor that mediates its effect through Sin3A and the DNA binding domain of nuclear hormone receptors. Molecular and cellular biology 154 11259580
2017 Human THO-Sin3A interaction reveals new mechanisms to prevent R-loops that cause genome instability. The EMBO journal 115 29074626
2003 Smad-dependent recruitment of a histone deacetylase/Sin3A complex modulates the bone morphogenetic protein-dependent transcriptional repressor activity of Nkx3.2. Molecular and cellular biology 88 14612411
2000 The minimal repression domain of MBD2b overlaps with the methyl-CpG-binding domain and binds directly to Sin3A. The Journal of biological chemistry 85 10950960
2013 Epstein-Barr virus nuclear antigen 3C binds to BATF/IRF4 or SPI1/IRF4 composite sites and recruits Sin3A to repress CDKN2A. Proceedings of the National Academy of Sciences of the United States of America 84 24344258
2018 The SIN3A histone deacetylase complex is required for a complete transcriptional response to hypoxia. Nucleic acids research 81 29059365
2016 Haploinsufficiency of MeCP2-interacting transcriptional co-repressor SIN3A causes mild intellectual disability by affecting the development of cortical integrity. Nature genetics 76 27399968
2012 The Sin3a repressor complex is a master regulator of STAT transcriptional activity. Proceedings of the National Academy of Sciences of the United States of America 76 22783022
2009 Repression of ESR1 through actions of estrogen receptor alpha and Sin3A at the proximal promoter. Molecular and cellular biology 76 19620290
2005 The ErbB3 binding protein Ebp1 interacts with Sin3A to repress E2F1 and AR-mediated transcription. Nucleic acids research 74 16254079
2004 MeCP2 behaves as an elongated monomer that does not stably associate with the Sin3a chromatin remodeling complex. The Journal of biological chemistry 72 15322089
2007 Adamantyl-substituted retinoid-related molecules bind small heterodimer partner and modulate the Sin3A repressor. Cancer research 67 17210713
2013 Increased binding of stroke-induced long non-coding RNAs to the transcriptional corepressors Sin3A and coREST. ASN neuro 63 24063527
2018 LSD1 coordinates with the SIN3A/HDAC complex and maintains sensitivity to chemotherapy in breast cancer. Journal of molecular cell biology 62 29741645
2010 Sin3a is required by sertoli cells to establish a niche for undifferentiated spermatogonia, germ cell tumors, and spermatid elongation. Stem cells (Dayton, Ohio) 59 20572009
2014 Sin3a-associated Hdac1 and Hdac2 are essential for hematopoietic stem cell homeostasis and contribute differentially to hematopoiesis. Haematologica 56 24763403
2012 Sin3a acts through a multi-gene module to regulate invasion in Drosophila and human tumors. Oncogene 56 22890320
2011 Sin3a is essential for the genome integrity and viability of pluripotent cells. Developmental biology 55 22206758
2011 The opposing transcriptional functions of Sin3a and c-Myc are required to maintain tissue homeostasis. Nature cell biology 54 22101514
2018 Sin3a-Tet1 interaction activates gene transcription and is required for embryonic stem cell pluripotency. Nucleic acids research 52 29733394
2011 Interplay between SIN3A and STAT3 mediates chromatin conformational changes and GFAP expression during cellular differentiation. PloS one 50 21779366
2017 Fam60a defines a variant Sin3a-Hdac complex in embryonic stem cells required for self-renewal. The EMBO journal 46 28554894
2013 Epigenetic silencing of the proapoptotic gene BIM in anaplastic large cell lymphoma through an MeCP2/SIN3a deacetylating complex. Neoplasia (New York, N.Y.) 46 23633923
2001 5'TG3' interacting factor interacts with Sin3A and represses AR-mediated transcription. Molecular endocrinology (Baltimore, Md.) 45 11682623
2014 MiR-210 up-regulation inhibits proliferation and induces apoptosis in glioma cells by targeting SIN3A. Medical science monitor : international medical journal of experimental and clinical research 43 25481483
2011 The developmental regulator protein Gon4l associates with protein YY1, co-repressor Sin3a, and histone deacetylase 1 and mediates transcriptional repression. The Journal of biological chemistry 43 21454521
2008 T-bet dependent removal of Sin3A-histone deacetylase complexes at the Ifng locus drives Th1 differentiation. Journal of immunology (Baltimore, Md. : 1950) 41 19050254
1996 Mouse Sin3A interacts with and can functionally substitute for the amino-terminal repression of the Myc antagonist Mxi1. Oncogene 41 8649810
2017 Sin3a regulates epithelial progenitor cell fate during lung development. Development (Cambridge, England) 36 28619823
2014 CRL4B interacts with and coordinates the SIN3A-HDAC complex to repress CDKN1A and drive cell cycle progression. Journal of cell science 36 25189618
2019 The Transcriptional Regulator Sin3A Contributes to the Oncogenic Potential of STAT3. Cancer research 35 30692217
2016 SIN3A and SIN3B differentially regulate breast cancer metastasis. Oncotarget 35 27780928
2015 Down regulation of miR-202 modulates Mxd1 and Sin3A repressor complexes to induce apoptosis of pancreatic cancer cells. Cancer biology & therapy 35 25611699
2009 The homeobox gene Mohawk represses transcription by recruiting the sin3A/HDAC co-repressor complex. Developmental dynamics : an official publication of the American Association of Anatomists 34 19235719
2011 Structure of the 30-kDa Sin3-associated protein (SAP30) in complex with the mammalian Sin3A corepressor and its role in nucleic acid binding. The Journal of biological chemistry 33 21676866
2008 Protein kinase Calpha-induced derepression of the human luteinizing hormone receptor gene transcription through ERK-mediated release of HDAC1/Sin3A repressor complex from Sp1 sites. Molecular endocrinology (Baltimore, Md.) 33 18372343
2004 Chick Dach1 interacts with the Smad complex and Sin3a to control AER formation and limb development along the proximodistal axis. Development (Cambridge, England) 33 15280207
2020 Berberine chloride suppresses non-small cell lung cancer by deregulating Sin3A/TOP2B pathway in vitro and in vivo. Cancer chemotherapy and pharmacology 32 32607786
2007 Decreased expression of the SIN3A gene, a candidate tumor suppressor located at the prevalent allelic loss region 15q23 in non-small cell lung cancer. Lung cancer (Amsterdam, Netherlands) 31 17854949
2006 SAP30L interacts with members of the Sin3A corepressor complex and targets Sin3A to the nucleolus. Nucleic acids research 31 16820529
2021 Comprehensive study of 28 individuals with SIN3A-related disorder underscoring the associated mild cognitive and distinctive facial phenotype. European journal of human genetics : EJHG 30 33437032
2018 Sin3A recruits Tet1 to the PAH1 domain via a highly conserved Sin3-Interaction Domain. Scientific reports 30 30279502
2010 Maximum growth and survival of estrogen receptor-alpha positive breast cancer cells requires the Sin3A transcriptional repressor. Molecular cancer 27 20920219
2004 The highly conserved region of the co-repressor Sin3A functionally interacts with the co-repressor Alien. Nucleic acids research 27 15173382
2019 miR-210-3p regulates the proliferation and apoptosis of non-small cell lung cancer cells by targeting SIN3A. Experimental and therapeutic medicine 26 31555365
2015 Targeting the SIN3A-PF1 interaction inhibits epithelial to mesenchymal transition and maintenance of a stem cell phenotype in triple negative breast cancer. Oncotarget 26 26460951
2009 SHP and Sin3A expression are essential for adamantyl-substituted retinoid-related molecule-mediated nuclear factor-kappaB activation, c-Fos/c-Jun expression, and cellular apoptosis. Molecular cancer therapeutics 25 19509248
2017 Chromatin remodeling system p300-HDAC2-Sin3A is involved in Arginine Starvation-Induced HIF-1α Degradation at the ASS1 promoter for ASS1 Derepression. Scientific reports 24 28883660
2015 Sin3A-associated protein, 18 kDa, a novel binding partner of TRIB1, regulates MTTP expression. Journal of lipid research 24 25921304
2012 Distinct requirements for Sin3a in perinatal male gonocytes and differentiating spermatogonia. Developmental biology 24 23085237
2024 Oxidative stress promotes liver fibrosis by modulating the microRNA-144 and SIN3A-p38 pathways in hepatic stellate cells. International journal of biological sciences 22 38725842
2023 Nuclear complement C3b promotes paclitaxel resistance by assembling the SIN3A/HDAC1/2 complex in non-small cell lung cancer. Cell death & disease 22 37291119
2010 Sumoylation of ING2 regulates the transcription mediated by Sin3A. Oncogene 22 20676127
2014 Whole-genome analysis of muscle founder cells implicates the chromatin regulator Sin3A in muscle identity. Cell reports 21 25088419
2012 Chromatin associated Sin3A is essential for male germ cell lineage in the mouse. Developmental biology 20 22820070
2020 Transcriptional corepressor SIN3A regulates hippocampal synaptic plasticity via Homer1/mGluR5 signaling. JCI insight 19 32069266
2003 Differential binding of Sin3 interacting repressor domains to the PAH2 domain of Sin3A. FEBS letters 18 12885416
2019 Sin3a regulates the developmental progression through morula-to-blastocyst transition via Hdac1. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 17 31450981
2018 A novel somatic mutation of SIN3A detected in breast cancer by whole-exome sequencing enhances cell proliferation through ERα expression. Scientific reports 17 30375428
2021 Transcription Repressor Protein ZBTB25 Associates with HDAC1-Sin3a Complex in Mycobacterium tuberculosis-Infected Macrophages, and Its Inhibition Clears Pathogen by Autophagy. mSphere 16 33627504
2021 Invasive phenotype in triple negative breast cancer is inhibited by blocking SIN3A-PF1 interaction through KLF9 mediated repression of ITGA6 and ITGB1. Translational oncology 15 34968869
2020 Coregulator Sin3a Promotes Postnatal Murine β-Cell Fitness by Regulating Genes in Ca2+ Homeostasis, Cell Survival, Vesicle Biosynthesis, Glucose Metabolism, and Stress Response. Diabetes 15 32245798
2016 Targeted interference of SIN3A-TGIF1 function by SID decoy treatment inhibits Wnt signaling and invasion in triple negative breast cancer cells. Oncotarget 15 29179446
2021 Epigenetic Silencing of BMP6 by the SIN3A-HDAC1/2 Repressor Complex Drives Melanoma Metastasis via FAM83G/PAWS1. Molecular cancer research : MCR 14 34610961
2019 ARID1A-SIN3A drives retinoic acid-induced neuroblastoma differentiation by transcriptional repression of TERT. Molecular carcinogenesis 14 31365169
2016 Correlation of SIN3A genomic variants with β-hemoglobinopathies disease severity and hydroxyurea treatment efficacy. Pharmacogenomics 14 27767389
2015 t(15;21) translocations leading to the concurrent downregulation of RUNX1 and its transcription factor partner genes SIN3A and TCF12 in myeloid disorders. Molecular cancer 14 26671595
2014 SIN3A, generally regarded as a transcriptional repressor, is required for induction of gene transcription by the aryl hydrocarbon receptor. The Journal of biological chemistry 14 25305016
2022 DNA methylation episignature for Witteveen-Kolk syndrome due to SIN3A haploinsufficiency. Genetics in medicine : official journal of the American College of Medical Genetics 13 36399132
2023 Tet2 regulates Sin3a recruitment at active enhancers in embryonic stem cells. iScience 12 37456851
2018 SINHCAF/FAM60A and SIN3A specifically repress HIF-2α expression. The Biochemical journal 12 29784889
2018 Loss of Fam60a, a Sin3a subunit, results in embryonic lethality and is associated with aberrant methylation at a subset of gene promoters. eLife 12 30070635
2023 Endothelin-1 induces connective tissue growth factor expression in human lung fibroblasts by disrupting HDAC2/Sin3A/MeCP2 corepressor complex. Journal of biomedical science 11 37312162
2006 Coupled unfolding and dimerization by the PAH2 domain of the mammalian Sin3A corepressor. Journal of molecular biology 11 16813833
2022 Suppression of SIN3A by miR-183 Promotes Breast Cancer Metastasis. Molecular cancer research : MCR 10 35247910
2022 Transcriptome Analysis of Schwann Cells at Various Stages of Myelination Implicates Chromatin Regulator Sin3A in Control of Myelination Identity. Neuroscience bulletin 10 35397705
2018 Transcriptional co-repressor SIN3A silencing rescues decline in memory consolidation during scopolamine-induced amnesia. Journal of neurochemistry 10 29494759
2016 Blocking the PAH2 domain of Sin3A inhibits tumorigenesis and confers retinoid sensitivity in triple negative breast cancer. Oncotarget 10 27286261
2012 SAP30L (Sin3A-associated protein 30-like) is involved in regulation of cardiac development and hematopoiesis in zebrafish embryos. Journal of cellular biochemistry 10 22821512
2024 Suppression of the long non-coding RNA LINC01279 triggers autophagy and apoptosis in lung cancer by regulating FAK and SIN3A. Discover oncology 9 38168833
2022 Sin3a drives mesenchymal-to-epithelial transition through cooperating with Tet1 in somatic cell reprogramming. Stem cell research & therapy 9 35073971
2022 LINC00665 up-regulates SIN3A expression to modulate the progression of colorectal cancer via sponging miR-138-5p. Cancer cell international 9 35101035
2022 LncRNA affects epigenetic reprogramming of porcine embryo development by regulating global epigenetic modification and the downstream gene SIN3A. Frontiers in physiology 9 36187791
2024 SIN3A histone deacetylase action counteracts MUS81 to promote stalled fork stability. Cell reports 8 38341854
2023 The transcriptional regulator Sin3A balances IL-17A and Foxp3 expression in primary CD4 T cells. EMBO reports 8 36929576
2021 SIN3A Regulates Porcine Early Embryonic Development by Modulating CCNB1 Expression. Frontiers in cell and developmental biology 7 33692994
2020 Electroacupuncture reduces scopolamine-induced amnesia via mediating the miR-210/SIN3A and miR-183/SIN3A signaling pathway. Molecular medicine (Cambridge, Mass.) 7 33183243
2024 Silencing of the long non-coding RNA LINC00265 triggers autophagy and apoptosis in lung cancer by reducing protein stability of SIN3A oncogene. Oncology research 6 38948024
2023 SIN3A Defects Associated with Syndromic Congenital Hypogonadotropic Hypogonadism: An Overlap with Witteveen-Kolk Syndrome. Neuroendocrinology 6 36758531
2018 A positive role of Sin3A in regulating Notch signaling during Drosophila wing development. Cellular signalling 6 30316814
2012 Identification of genetic suppressors of the Sin3A knockdown wing phenotype. PloS one 6 23166712
2022 An Overfeeding-Induced Obesity Mouse Model Reveals Necessity for Sin3a in Postnatal Peak β-Cell Mass Acquisition. Diabetes 5 35944274
2021 Ambiguity about Splicing Factor 3b Subunit 3 (SF3B3) and Sin3A Associated Protein 130 (SAP130). Cells 5 33800128
2019 Where Sin3a Meets STAT3: Balancing STAT3-Mediated Transcriptional Activation and Repression. Cancer research 5 31201166
2018 Identification of Novel Functional Variants of SIN3A and SRSF1 among Somatic Variants in Acute Myeloid Leukemia Patients. Molecules and cells 5 29764005
2016 Pits, a protein interacting with Ttk69 and Sin3A, has links to histone deacetylation. Scientific reports 4 27622813

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