Metastasis-associated protein MTA2 · UniProt O94776
MTA2 is a core subunit of the NuRD (nucleosome remodeling and histone deacetylase) complex that represses transcription by recruiting HDAC1 to target promoters to deacetylate histones (PMID:18353770, PMID:23086931). Within NuRD it interacts with MBD3 (PMID:12124384) and forms a stable elongated MTA2-RBBP7 module of 2:4 stoichiometry that represents an initial assembly intermediate of the complex (PMID:28179136). Through this repressive activity MTA2 controls diverse developmental and immune programs: it silences cytokine genes such as IL-4 in T cells, with its loss causing lupus-like autoimmunity (PMID:18353770); it maintains genomic imprinting of H19 and Peg3 in preimplantation embryos (PMID:20720167); it acts as a corepressor of FSHR transcription in Sertoli cells (PMID:23086931); it represses Igll1 and VpreB1 via histone deacetylation during B cell development in association with AIOLOS/IKAROS (PMID:31291582); and it restrains colonic cell identity by retaining HNF4A on colonic chromatin as part of a SATB2-MTA2 complex (PMID:38678016). In cancer, MTA2 is frequently co-opted to repress tumor-suppressor and epithelial genes such as E-cadherin and PTEN through partnerships with Snail, Twist, AIB1 and HIF-1α, driving EMT and metastasis (PMID:29708271, PMID:30814496, PMID:33340431, PMID:33420368). Beyond chromatin, MTA2 has a replication-associated role: it binds Tipin to support Polymerase α loading onto replicating chromatin and to prevent accumulation of reversed forks at difficult-to-replicate regions (PMID:24830473). MTA2 activity is itself tuned by post-translational regulation, including acetylation at K152 by p300 (PMID:24468085) and proteolytic and ubiquitination-controlled turnover (PMID:30642362).
Establishing the gene's existence and relationship to MTA1 was the first step, defining MTA2 as a distinct, broadly expressed family member.
Evidence cDNA cloning, Northern blot and FISH mapping (as MTA1-L1)
Placing MTA2 in a defined complex answered how it physically connects to chromatin machinery, identifying it as an MBD3-interacting NuRD subunit alongside HDAC1.
Evidence Recombinant protein binding assays with wild-type/mutant MBD3
Loss-of-function in mice tested the in vivo role of MTA2-NuRD, establishing it as a transcriptional repressor of cytokine genes whose loss causes autoimmunity.
Evidence Whole-body and T cell-specific knockout mice with ChIP-based IL-4 target identification
Embryo knockdown addressed whether MTA2 maintains epigenetic marks, showing it is required for genomic imprinting at H19 and Peg3.
Evidence RNAi in mouse preimplantation embryos, allele-specific expression and bisulfite sequencing
The Sertoli cell study dissected a specific corepressor pathway, showing MTA2 recruits HDAC1 to the FSHR promoter within a negative-feedback loop.
Evidence siRNA knockdown, ChIP, and deacetylase activity assays in Sertoli cells
Identification of K152 acetylation by p300 revealed how MTA2 activity is post-translationally tuned and linked to cancer cell behavior.
Evidence Co-IP, site-directed mutagenesis, proliferation and migration assays
The Tipin interaction uncovered a chromatin-replication role distinct from transcriptional repression, placing MTA2 at replication forks supporting Polymerase α loading.
Evidence Xenopus egg extract replication reconstitution, Co-IP, locus-specific replication assay
Structural characterization defined the architecture of the initial NuRD assembly module, showing MTA2-RBBP7 forms an elongated 2:4 complex.
Evidence Purification from HEK293F and negative-stain EM with 3D reconstruction
Multiple studies clarified context-specific partners and targets: AIOLOS/IKAROS in B cell development and Snail-directed PTEN repression in cancer.
Evidence Knockout mice, ChIP-seq, H3K27ac analysis, Co-IP, luciferase assays
Cross-regulation between paralogs was defined, with MTA1 driving neutrophil elastase-mediated cleavage of MTA2 at specific C-terminal sites.
Evidence Immunoblotting, truncation/mutation analysis, NE inhibitor/knockdown
A series of cancer studies established MTA2 as an EMT/metastasis driver recruited by Twist, AIB1 and others to repress E-cadherin, and as a regulator of replication-stress sensitivity.
Evidence Co-IP, ChIP, CUT&TAG origin-binding, PARP inhibitor sensitivity, xenografts
PMID:33340431 PMID:33420368 PMID:34280886
The colonic identity study provided a high-resolution developmental mechanism, defining a SATB2-MTA2 complex that retains HNF4A on colonic chromatin to restrain plasticity.
Evidence Proteomics, CRISPR screen, ChIP-seq co-occupancy, colon-specific knockout mice
Stability regulation was extended, showing HMGB2 stabilizes MTA2 against ubiquitination to support HIF-1α-driven cardiomyocyte proliferation.
Evidence IP-MS, RNA-seq, cardiomyocyte-specific manipulation in MI model
| Year | Finding | Method | Journal | Conf | PMIDs |
|---|---|---|---|---|---|
| 2002 | MBD3's methyl-CpG-binding domain (MBD) is necessary and sufficient for binding to HDAC1 and MTA2, two components of the NuRD/Mi2 complex, establishing MTA2 as an MBD3-interacting partner within the NuRD complex. | Recombinant protein binding assays with wild-type and mutant MBD3 proteins | The Journal of biological chemistry | Medium | 12124384 |
| 1999 | MTA2 (originally cloned as MTA1-L1) encodes a 668 amino acid protein with 59.6% identity to MTA1, is ubiquitously expressed as a 3.0-kb transcript, and maps to chromosomal band 11q12-13.1. | cDNA cloning, Northern blot, FISH | Journal of human genetics | Medium | 9929979 |
| 2008 | Mta2 knockout in mice causes lupus-like autoimmune disease with T cell hyperproliferation and hyperinduction of IL-2, IL-4, and IFN-γ; IL-4 was identified as a direct transcriptional target of Mta2/NuRD, establishing MTA2 as a repressor of cytokine gene expression in T cells. | Knockout mouse model, bone marrow transplantation, T cell-specific knockout, gene expression analysis, chromatin immunoprecipitation | The Journal of biological chemistry | High | 18353770 |
| 2010 | RNAi-mediated knockdown of MTA2 in mouse preimplantation embryos leads to biallelic expression of the normally maternally-expressed H19 gene and loss of DNA methylation at the H19 differentially methylated region, and biallelic expression of the paternally-expressed Peg3 gene, demonstrating MTA2 is required within the NuRD complex for maintaining genomic imprinting. | RNAi knockdown in mouse embryos, allele-specific expression analysis, bisulfite sequencing | Biology of reproduction | High | 20720167 |
| 2012 | MTA2 is exclusively expressed in Sertoli cells (SCs) and acts as a corepressor of FSHR transcription by recruiting HDAC1 to the FSHR promoter, participating in FSH-induced desensitization; the FSH/androgen receptor/MTA2 cascade constitutes a negative feedback loop modulating FSH signaling. | siRNA knockdown, ChIP assay, deacetylase activity assay, gene expression analysis in Sertoli cells | The Journal of biological chemistry | High | 23086931 |
| 2013 | Transcription factor Sp1 binds to the MTA2 gene promoter at the region -1043 bp to -843 bp and enhances MTA2 transcriptional activity, establishing Sp1 as a transcriptional activator of MTA2. | Chromatin immunoprecipitation, luciferase reporter assay, Sp1 overexpression | Molecular cancer | Medium | 24010737 |
| 2014 | MTA2 is acetylated at lysine 152 by the histone acetyltransferase p300; mutation of the K152 acetylation site inhibits colorectal cancer cell growth and migration/invasion of Rat1 fibroblasts. | Co-immunoprecipitation, site-directed mutagenesis, cell proliferation and migration assays | Biochemical and biophysical research communications | Medium | 24468085 |
| 2014 | Mta2 is a novel Tipin binding partner; Mta2 is required for Tipin-dependent Polymerase α binding to replicating chromatin and prevents accumulation of reversed replication forks; Tipin is directly required for efficient replication of vertebrate centromeric DNA. | Xenopus laevis egg extract replication assay, co-immunoprecipitation, specific genomic locus replication assay | Cell cycle (Georgetown, Tex.) | High | 24830473 |
| 2017 | Human MTA2 forms a stable complex with RBBP7; purified MTA2-RBBP7 complex shows an elongated architecture with hinge-like motion by negative-stain EM, consistent with a 2:4 stoichiometry analogous to the MTA1-RBBP4 complex, and represents an initial assembly module of the NuRD complex. | Protein expression/purification from HEK293F cells, negative-stain electron microscopy, 3D volume reconstruction | Biochimica et biophysica acta. Proteins and proteomics | Medium | 28179136 |
| 2018 | MTA2 is transcriptionally upregulated by HIF-1α through a hypoxia response element (HRE) in the MTA2 promoter; reciprocally, MTA2 deacetylates HIF-1α and enhances its stability via interaction with HDAC1; HIF-1α then recruits MTA2 and HDAC1 to the E-cadherin promoter to repress its transcription in pancreatic carcinoma. | ChIP assay, co-immunoprecipitation, luciferase reporter assay, overexpression and knockdown in vitro and in xenograft models | The Journal of pathology | Medium | 29708271 |
| 2019 | MTA2/NuRD directly interacts with AIOLOS/IKAROS in B cells and shows overlapping target genes; MTA2 deficiency leads to increased H3K27 acetylation at Igll1 and VpreB1 promoters, indicating MTA2/NuRD represses these genes via histone deacetylation during B cell development; MTA2 and OCA-B synergistically repress Igll1 and VpreB1 at the pre-B cell stage. | Co-immunoprecipitation, knockout mouse model, ChIP-seq, H3K27 acetylation analysis, B cell developmental phenotyping | Cell reports | High | 31291582 |
| 2019 | MTA2 represses PTEN transcription by binding to the PTEN promoter, with Snail recruiting MTA2 and HDAC1 to suppress PTEN expression, thereby activating PI3K/AKT signaling in pancreatic ductal adenocarcinoma. | ChIP-seq, quantitative ChIP, luciferase reporter assay, overexpression/knockdown in vitro and xenograft models | Cell death & disease | Medium | 30814496 |
| 2019 | MTA1 overexpression promotes MTA2 protein degradation through neutrophil elastase (NE)-mediated proteolytic cleavage at specific C-terminal sites (486, 497, 542, 583, and 621), activated by MTA1-mediated epigenetic repression of the NE inhibitor elafin, establishing a cross-regulatory mechanism between MTA1 and MTA2. | Immunoblotting, qRT-PCR, NE inhibitor/knockdown/overexpression, MTA2 truncation and mutation analysis, immunocytochemistry | Cell communication and signaling : CCS | Medium | 30642362 |
| 2020 | MTA2 transcriptionally suppresses miR-7 expression, leading to increased Sp1 levels, which in turn drives KLK10 transcription to promote cervical cancer cell migration and invasion. | shRNA knockdown, gene expression analysis, luciferase reporter assay, ChIP, in vitro and in vivo functional assays | Molecular therapy. Nucleic acids | Medium | 32402941 |
| 2020 | MTA2 interacts with SerRS (seryl tRNA synthetase) and regulates SerRS transcription; an isoflavone derivative MEQ binds MTA2 to upregulate SerRS and thereby downregulate VEGFA, suppressing angiogenesis in triple-negative breast cancer. | Proteomics, biochemical studies, dual-luciferase reporter system, in vivo angiogenesis assays, xenograft models | Cancer biology & medicine | Low | 32944400 |
| 2021 | MTA2 silencing reduces MMP12 expression in cervical cancer cells via the ASK1/MEK3/p38/YB1 signaling axis; p38-mediated YB1 phosphorylation disrupts AP1 (c-Fos/c-Jun) binding to the MMP12 promoter, thereby inhibiting MMP12 expression and metastasis. | shRNA knockdown, ChIP assay, Western blotting, in vitro and in vivo invasion assays, xenograft models | Cell death & disease | Medium | 33958583 |
| 2021 | MTA2 interacts with EIF4E (eukaryotic initiation factor 4E), which positively regulates Twist expression; Twist then recruits MTA2 to the E-cadherin promoter to reduce histone acetylation and suppress E-cadherin expression, promoting EMT in esophageal squamous cell carcinoma. | Co-immunoprecipitation, expression microarray, ChIP assay, in vitro and in vivo functional assays | Cancer science | Medium | 33340431 |
| 2021 | MTA2 preferentially binds replication origin-associated DNA sequences (by CUT&TAG assay), and MTA2 expression confers sensitivity to PARP inhibitor olaparib by aggravating olaparib-induced replication stress in gastric cancer cells. | CUT&TAG assay, proteomic profiling, PARP inhibitor sensitivity assays, ATR inhibitor combination studies | Translational oncology | Medium | 34280886 |
| 2021 | AIB1 interacts with MTA2 to form a repressive complex that inhibits CDH1 (E-cadherin) transcription, promoting EMT in ER+ breast cancer metastasis. | Interactome analysis (complementary RNAseq), CDX and PDX ex-vivo models, functional cancer assays | Oncogene | Medium | 33420368 |
| 2021 | lncRNA LINC00941 interacts with NuRD-associated MTA2 and CHD4 in human primary keratinocytes; LINC00941 perturbation changes MTA2/NuRD occupancy at bivalent chromatin domains near the EGR3 gene locus, leading to increased EGR3 expression and premature epidermal differentiation. | RNA immunoprecipitation, ChIP, gene expression analysis, keratinocyte differentiation assays | Life science alliance | Medium | 38649186 |
| 2024 | MTA2 co-occupies DNA with HNF4A on colonic chromatin; MTA2 loss leads to HNF4A release from colonic chromatin and its accumulation on small intestinal chromatin, activating lipid absorptive genes and converting colonic identity toward small intestinal identity, establishing MTA2 as part of a SATB2-MTA2 complex that restrains colonic plasticity by retaining HNF4A at colonic chromatin. | Proteomics, CRISPR-Cas9 screening, ChIP-seq, chromatin co-occupancy analysis, functional lipid uptake assays, mouse colon-specific knockout | Nature communications | High | 38678016 |
| 2025 | HMGB2 directly interacts with MTA2 and inhibits its ubiquitination-mediated degradation, thereby stabilizing HIF-1α protein and promoting glycolysis-dependent cardiomyocyte proliferation and heart regeneration. | Immunoprecipitation-mass spectrometry (IP-MS), RNA-seq, single-nucleus RNA-seq, cardiomyocyte-specific overexpression and knockdown in mice, myocardial infarction model | Advanced science (Weinheim, Baden-Wurttemberg, Germany) | Medium | 41092376 |
| 2024 | MTA2 is a direct target of miR-34a in endothelial cells; endothelial miR-34a deletion de-represses MTA2 to promote Ang II-induced EC proliferation and protect against abdominal aortic aneurysm formation. | miR-34a endothelial-specific knockout mice, Ang II AAA model, luciferase reporter (implied direct targeting), functional EC proliferation assays | bioRxivpreprint | Low | |
| 2016 | lncRNA SNHG5 interacts with MTA2 protein and prevents its translocation from the cytoplasm into the nucleus, leading to increased acetylation of histone H3 and p53 and interfering with NuRD complex formation. | RNA pulldown, Co-immunoprecipitation, subcellular fractionation, histone acetylation assays, overexpression in gastric cancer cells | Oncogene | Low | 27065326 |
| 2019 | MTA2 promotes HCC proliferation and metastasis through transcriptional repression of FRMD6 (a key upstream component of the Hippo signaling pathway), identified by genome-wide ChIP-seq. | ChIP-seq, knockdown/overexpression in vitro and in vivo xenograft models | Biochemical and biophysical research communications | Medium | 31128910 |
| 2023 | MTA2 directly binds the promoter of MCM5 (minichromosome maintenance deficient 5) to promote its expression, thereby facilitating gastric cancer growth and metastasis. | ChIP assay, in vitro and in vivo overexpression/knockdown functional assays | Journal of Cancer | Low | 36741260 |
| 2023 | MTA2 knockdown in HCC cells downregulates PTK7 expression, and PTK7 regulates MMP7 expression and cell migration/invasion through FAK signaling, establishing an MTA2-PTK7-FAK-MMP7 axis in HCC metastasis. | siRNA knockdown, FAK inhibitor, recombinant human MMP7 rescue assay, migration/invasion assays | Environmental toxicology | Low | 38050825 |
| 2024 | MTA2 knockdown reduces uPA (urokinase-type plasminogen activator) expression in osteosarcoma cells via ERK1/2 signaling, inhibiting cell migration and invasion; recombinant uPA rescues migration in MTA2-knockdown cells. | shRNA knockdown, recombinant human uPA rescue assay, ERK depletion, in vivo metastasis model | Aging | Low | 39248711 |
| Year | Title | Journal | Citations | PMID |
|---|---|---|---|---|
| 2002 | The mCpG-binding domain of human MBD3 does not bind to mCpG but interacts with NuRD/Mi2 components HDAC1 and MTA2. | The Journal of biological chemistry | 143 | 12124384 |
| 2016 | Long non-coding RNA SNHG5 suppresses gastric cancer progression by trapping MTA2 in the cytosol. | Oncogene | 99 | 27065326 |
| 2013 | MTA2 promotes gastric cancer cells invasion and is transcriptionally regulated by Sp1. | Molecular cancer | 66 | 24010737 |
| 2012 | Sertoli cell-specific expression of metastasis-associated protein 2 (MTA2) is required for transcriptional regulation of the follicle-stimulating hormone receptor (FSHR) gene during spermatogenesis. | The Journal of biological chemistry | 62 | 23086931 |
| 2008 | Inactivation of NuRD component Mta2 causes abnormal T cell activation and lupus-like autoimmune disease in mice. | The Journal of biological chemistry | 52 | 18353770 |
| 2014 | Role of MTA2 in human cancer. | Cancer metastasis reviews | 51 | 25394532 |
| 2018 | miR-1236-3p inhibits invasion and metastasis in gastric cancer by targeting MTA2. | Cancer cell international | 48 | 29743816 |
| 1999 | Molecular cloning, mapping, and characterization of a novel human gene, MTA1-L1, showing homology to a metastasis-associated gene, MTA1. | Journal of human genetics | 36 | 9929979 |
| 2019 | MTA2/NuRD Regulates B Cell Development and Cooperates with OCA-B in Controlling the Pre-B to Immature B Cell Transition. | Cell reports | 33 | 31291582 |
| 2021 | MTA2 silencing attenuates the metastatic potential of cervical cancer cells by inhibiting AP1-mediated MMP12 expression via the ASK1/MEK3/p38/YB1 axis. | Cell death & disease | 27 | 33958583 |
| 2018 | Reciprocal loop of hypoxia-inducible factor-1α (HIF-1α) and metastasis-associated protein 2 (MTA2) contributes to the progression of pancreatic carcinoma by suppressing E-cadherin transcription. | The Journal of pathology | 26 | 29708271 |
| 2015 | MTA2 enhances colony formation and tumor growth of gastric cancer cells through IL-11. | BMC cancer | 26 | 25929737 |
| 2012 | Expression of metastasis-associated protein 2 (MTA2) might predict proliferation in non-small cell lung cancer. | Targeted oncology | 26 | 22585429 |
| 2014 | P300 binds to and acetylates MTA2 to promote colorectal cancer cells growth. | Biochemical and biophysical research communications | 24 | 24468085 |
| 2015 | Metastasis-associated protein 2 (MTA2) promotes the metastasis of non-small-cell lung cancer through the inhibition of the cell adhesion molecule Ep-CAM and E-cadherin. | Japanese journal of clinical oncology | 23 | 25969565 |
| 2019 | MTA2 as a Potential Biomarker and Its Involvement in Metastatic Progression of Human Renal Cancer by miR-133b Targeting MMP-9. | Cancers | 22 | 31771219 |
| 2010 | Metastasis tumor antigen 2 (MTA2) is involved in proper imprinted expression of H19 and Peg3 during mouse preimplantation development. | Biology of reproduction | 22 | 20720167 |
| 2021 | SNHG5 inhibits the progression of EMT through the ubiquitin-degradation of MTA2 in oesophageal cancer. | Carcinogenesis | 21 | 33095847 |
| 2019 | MTA2-mediated inhibition of PTEN leads to pancreatic ductal adenocarcinoma carcinogenicity. | Cell death & disease | 21 | 30814496 |
| 2006 | Expression of MTA2 gene in ovarian epithelial cancer and its clinical implication. | Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban | 19 | 16961294 |
| 2021 | Comparative analysis of the AIB1 interactome in breast cancer reveals MTA2 as a repressive partner which silences E-Cadherin to promote EMT and associates with a pro-metastatic phenotype. | Oncogene | 17 | 33420368 |
| 2019 | MTA2 promotes HCC progression through repressing FRMD6, a key upstream component of hippo signaling pathway. | Biochemical and biophysical research communications | 17 | 31128910 |
| 2012 | Correlation between MTA2 overexpression and tumour progression in esophageal squamous cell carcinoma. | Experimental and therapeutic medicine | 16 | 22969963 |
| 2020 | Transcriptional Suppression of miR-7 by MTA2 Induces Sp1-Mediated KLK10 Expression and Metastasis of Cervical Cancer. | Molecular therapy. Nucleic acids | 15 | 32402941 |
| 2014 | Mta2 promotes Tipin-dependent maintenance of replication fork integrity. | Cell cycle (Georgetown, Tex.) | 15 | 24830473 |
| 2014 | Short-hairpin RNA-mediated MTA2 silencing inhibits human breast cancer cell line MDA-MB231 proliferation and metastasis. | Asian Pacific journal of cancer prevention : APJCP | 13 | 25081667 |
| 2022 | lncRNA PCAT1 might coordinate ZNF217 to promote CRC adhesion and invasion through regulating MTA2/MTA3/Snai1/E-cadherin signaling. | Cellular and molecular biology (Noisy-le-Grand, France) | 11 | 35809308 |
| 2021 | MTA2 promotes the metastasis of esophageal squamous cell carcinoma via EIF4E-Twist feedback loop. | Cancer science | 11 | 33340431 |
| 2020 | An isoflavone derivative potently inhibits the angiogenesis and progression of triple-negative breast cancer by targeting the MTA2/SerRS/VEGFA pathway. | Cancer biology & medicine | 11 | 32944400 |
| 2021 | Inhibition of MTA2 and MTA3 induces mesendoderm specification of human embryonic stem cells. | Biochemical and biophysical research communications | 9 | 33744762 |
| 2017 | Expression, purification and characterization of the human MTA2-RBBP7 complex. | Biochimica et biophysica acta. Proteins and proteomics | 9 | 28179136 |
| 2024 | A MTA2-SATB2 chromatin complex restrains colonic plasticity toward small intestine by retaining HNF4A at colonic chromatin. | Nature communications | 8 | 38678016 |
| 2021 | MTA2 sensitizes gastric cancer cells to PARP inhibition by induction of DNA replication stress. | Translational oncology | 8 | 34280886 |
| 2024 | CircMTA2 Drives Gastric Cancer Progression through Suppressing MTA2 Degradation via Interacting with UCHL3. | International journal of molecular sciences | 6 | 38474064 |
| 2024 | lncRNA LINC00941 modulates MTA2/NuRD occupancy to suppress premature human epidermal differentiation. | Life science alliance | 6 | 38649186 |
| 2021 | Long Noncoding RNA TTC39A-AS1 Promotes Breast Cancer Tumorigenicity by Sponging MicroRNA-483-3p and Thereby Upregulating MTA2. | Pharmacology | 6 | 34488224 |
| 2023 | MTA2 is one of 14 Transcription factors predicting recurrence free survival in gastric cancer and promotes cancer progression by targeting MCM5. | Journal of Cancer | 5 | 36741260 |
| 2023 | Loss of MTA2-mediated downregulation of PTK7 inhibits hepatocellular carcinoma metastasis progression by modulating the FAK-MMP7 axis. | Environmental toxicology | 4 | 38050825 |
| 2010 | [Expression and significance of MTA2 in non-small cell lung cancer]. | Zhongguo fei ai za zhi = Chinese journal of lung cancer | 4 | 20704817 |
| 2019 | Overexpression of MTA1 inhibits the metastatic ability of ZR-75-30 cells in vitro by promoting MTA2 degradation. | Cell communication and signaling : CCS | 3 | 30642362 |
| 2002 | Parallelizing a DNA simulation code for the Cray MTA-2. | Proceedings. IEEE Computer Society Bioinformatics Conference | 3 | 15838145 |
| 2025 | HMGB2 Promotes Cardiomyocyte Proliferation and Heart Regeneration Through MTA2-Driven Metabolic Reprogramming. | Advanced science (Weinheim, Baden-Wurttemberg, Germany) | 2 | 41092376 |
| 2012 | [Expression of metastasis associated 1 family member 2 (MTA2) in gastric cancer and its relationship with transcription factor Sp1]. | Zhonghua zhong liu za zhi [Chinese journal of oncology] | 2 | 23158992 |
| 2025 | AS1411 Aptamer-Conjugated Liposomal siRNA Targeting MTA2 Suppresses PI3K/AKT Signaling in Pancreatic Cancer Cells. | International journal of molecular sciences | 1 | 40943389 |
| 2024 | MTA2 knockdown suppresses human osteosarcoma metastasis by inhibiting uPA expression. | Aging | 0 | 39248711 |
| 2023 | Expression and Significance of MTA2 and CPNE1 in Cervical Squamous Cell Carcinoma. | Applied immunohistochemistry & molecular morphology : AIMM | 0 | 37399268 |
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