Affinage

MKI67

Proliferation marker protein Ki-67 · UniProt P46013

Length
3256 aa
Mass
358.7 kDa
Annotated
2026-06-10
100 papers in source corpus 12 papers cited in narrative 12 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 8/8 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

MKI67 (Ki-67) is a large intrinsically disordered protein that organizes the mitotic chromosome surface and coordinates nuclear reorganization across the cell cycle (PMID:27362226, PMID:24867636). On the mitotic chromosome periphery it acts as a biological surfactant, using its size and net charge to form brush-like polymer arrangements that create a steric/electrostatic barrier preventing chromosome aggregation after nuclear envelope breakdown (PMID:27362226). Ki-67 is the principal organizer of the perichromosomal compartment: its depletion abolishes association of nucleolar/periphery proteins—NIFK, B23/nucleophosmin, nucleolin and others—with the chromosome surface and eliminates the perichromosomal layer (PMID:24867636), and CCDC86/cyclon is a further periphery partner whose loss disorganizes this layer (PMID:36695333). Ki-67 binds protein phosphatase 1 (PP1) through a novel pocket-engaging mechanism shared with RepoMan, discriminates among PP1 isoforms, and assembles a Ki-67:PP1 holoenzyme whose formation is dynamically controlled by Aurora B kinase during mitotic exit (PMID:27572260). During mitotic exit the molecular brushes collapse to drive microtubule-independent chromosome clustering that physically excludes mature ribosomes and re-establishes nuclear-cytoplasmic compartmentalization (PMID:32879492). Ki-67 maintains mitotic chromosome integrity cooperatively with but independently of condensins, which occupy the chromosome axis while Ki-67 coats the periphery (PMID:29487178). Beyond mitosis, Ki-67 associates with rDNA chromatin and rRNA transcription machinery (PMID:16206250), engages large late-replicating genomic domains in competition with the nuclear lamina to control replication timing of (peri)centromeric regions (PMID:36245428), and is required for normal DNA replication—its acute degradation delays replication, unloads the replication machinery, triggers HUWE1-dependent DNA damage, sister chromatid cohesion defects, and cGAS/STING interferon signalling (PMID:38649976). Ki-67 transcription is repressed by IRF1, which lowers Sp1 protein levels acting at the Ki-67 core promoter (PMID:22890831).

Mechanistic history

Synthesis pass · year-by-year structured walk · 10 steps
  1. 2006 Medium

    Established the first direct genomic association of Ki-67, placing it at rDNA chromatin and rRNA transcription sites and implicating it in early steps of ribosomal RNA synthesis.

    Evidence ChIP and immunofluorescence co-localization with a novel antibody in proliferating and quiescent cells

    PMID:16206250

    Open questions at the time
    • No demonstration that Ki-67 is functionally required for rRNA synthesis
    • Single lab without genetic perturbation of transcriptional output
  2. 2012 Medium

    Defined a transcriptional control mechanism for Ki-67, showing its promoter is governed by Sp1 and repressed by IRF1 via reduction of Sp1 protein.

    Evidence Promoter-reporter assays with Sp1-site mutagenesis and IRF1 overexpression in cell lines

    PMID:22890831

    Open questions at the time
    • Mechanism by which IRF1 reduces Sp1 protein not resolved
    • Not validated at the endogenous chromatin level in vivo
  3. 2014 High

    Identified Ki-67 as a PP1-binding protein and the essential organizer of the perichromosomal compartment, explaining how the chromosome surface layer is built.

    Evidence siRNA depletion, CLEM, and co-immunoprecipitation in human cells

    PMID:24867636

    Open questions at the time
    • Structural basis of PP1 binding not yet defined here
    • Functional consequence of periphery loss for downstream processes unresolved
  4. 2016 High

    Resolved the biophysical basis of Ki-67's chromosome-separation function, showing it behaves as a charged polymer surfactant whose activity depends on size and charge rather than a discrete catalytic domain.

    Evidence Truncation mutagenesis, fluorescence correlation spectroscopy, and dual-terminus live-cell imaging with mitotic readouts

    PMID:27362226

    Open questions at the time
    • Does not address Ki-67 interphase functions
    • Identity of partners contributing to surface charge not enumerated
  5. 2016 High

    Provided the structural mechanism of Ki-67:PP1 holoenzyme assembly, revealing a novel PP1 pocket engagement shared with RepoMan and Aurora B-dependent regulation of mitotic exit phosphatase activity.

    Evidence Structural analysis, biochemical binding assays, and Aurora B kinase assays with mutagenesis

    PMID:27572260

    Open questions at the time
    • In vivo substrates of the Ki-67:PP1 holoenzyme not fully mapped
    • Quantitative contribution to mitotic exit timing not measured
  6. 2018 High

    Distinguished Ki-67's contribution to chromosome architecture from that of condensins, showing peripheral and axial systems act independently but cooperatively.

    Evidence Auxin-inducible degron depletion of Ki-67 and SMC2 with epistasis readouts in HCT116 cells

    PMID:29487178

    Open questions at the time
    • Molecular interface between periphery and axis not defined
    • Whether cooperation reflects physical or purely mechanical interaction unknown
  7. 2020 High

    Explained how Ki-67 contributes to nuclear reformation, showing brush collapse drives chromosome clustering that excludes ribosomes and re-establishes compartmentalization at mitotic exit.

    Evidence Live-cell imaging, depletion/rescue, and ribosome exclusion assays in HeLa cells

    PMID:32879492

    Open questions at the time
    • Trigger for brush collapse not molecularly defined
    • Relationship to PP1-dependent dephosphorylation not directly linked
  8. 2022 Medium

    Mapped Ki-67's interphase genomic engagement, showing it binds late-replicating domains in competition with the lamina and controls replication timing of (peri)centromeric regions.

    Evidence pA-DamID genome-wide mapping, nucleolar perturbation, and replication timing assays in human cells

    PMID:36245428

    Open questions at the time
    • No effect on chromatin-chromatin interactions detected, leaving organizational role narrow
    • Single-lab genome-wide approach
  9. 2023 Medium

    Extended the perichromosomal interactome by identifying CCDC86/cyclon as a Ki-67 partner required for proper periphery organization and faithful chromosome segregation.

    Evidence Co-IP/pulldown, RNAi, and immunofluorescence with multiple cellular endpoints

    PMID:36695333

    Open questions at the time
    • Direct vs. indirect nature of the Ki-67-CCDC86 interaction not resolved
    • Single lab without reciprocal structural validation
  10. 2024 High

    Revealed an interphase requirement for Ki-67 in DNA replication and genome stability, linking its loss to replication delay, non-canonical DNA damage, and innate immune signalling.

    Evidence Acute inducible degradation, APEX2 proximity proteomics, phospho-proteomics, and DNA fiber assays in HCT116 cells

    PMID:38649976

    Open questions at the time
    • Direct molecular role of Ki-67 at replication forks vs. proximal association unresolved
    • Mechanism connecting Ki-67 loss to HUWE1-dependent damage not defined

Open questions

Synthesis pass · forward-looking unresolved questions
  • How Ki-67's mitotic surfactant role mechanistically integrates with its interphase functions in rRNA synthesis, replication timing, and fork protection remains unresolved.
  • No unified model linking the disordered-polymer biophysics to replication-fork function
  • Substrate map of the Ki-67:PP1 holoenzyme incomplete
  • Whether interphase phenotypes derive from nucleolar organization or direct chromatin engagement unclear

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0003677 DNA binding 2 GO:0005198 structural molecule activity 2 GO:0140096 catalytic activity, acting on a protein 2 GO:0060090 molecular adaptor activity 1 GO:0098772 molecular function regulator activity 1
Localization
GO:0005694 chromosome 3 GO:0005730 nucleolus 3 GO:0000228 nuclear chromosome 2 GO:0005634 nucleus 1
Pathway
R-HSA-1640170 Cell Cycle 4 R-HSA-69306 DNA Replication 2 R-HSA-168256 Immune System 1 R-HSA-74160 Gene expression (Transcription) 1 R-HSA-8953854 Metabolism of RNA 1
Partners
AURKBCCDC86NCLNIFKNPM1PPP1CASMC2
Complex memberships
Ki-67:PP1 holoenzymeperichromosomal layer/compartment

Evidence

Reading pass · 12 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2016 Ki-67 functions as a biological surfactant on the mitotic chromosome periphery, preventing chromosome aggregation after nuclear envelope disassembly. The chromosome separation function correlates with the size and net charge of the protein rather than a specific domain, suggesting a steric and electrostatic charge barrier mechanism. Fluorescence correlation spectroscopy demonstrated high surface density of Ki-67, and dual-colour labelling of both protein termini revealed an extended molecular conformation consistent with brush-like polymer surfactant arrangements. Truncation mutagenesis, fluorescence correlation spectroscopy, dual-colour live-cell imaging, siRNA depletion with mitotic phenotype readout Nature High 27362226
2014 Ki-67 is a cell-cycle-regulated protein phosphatase 1 (PP1)-binding protein required for assembly of the perichromosomal compartment. siRNA depletion of Ki-67 causes failure of multiple nucleolar/periphery proteins (NIFK, B23/nucleophosmin, nucleolin, and four novel periphery proteins) to associate with the chromosome periphery, with CLEM showing near-complete loss of the perichromosomal layer. Ki-67 is also involved in phospho-regulation of B23/nucleophosmin. siRNA depletion, correlative light and electron microscopy (CLEM), co-immunoprecipitation, immunofluorescence eLife High 24867636
2016 Ki-67 and RepoMan recruit protein phosphatase 1 (PP1) to form mitotic exit phosphatases via an identical, novel mechanism, interacting with a PP1 pocket not engaged by any other known PP1 regulator. Ki-67 distinguishes between distinct PP1 isoforms, and the assembly of the Ki-67:PP1 holoenzyme is dynamically regulated by Aurora B kinase during mitosis. Structural analysis (NMR/crystallography), biochemical binding assays, mutagenesis, kinase assays with Aurora B eLife High 27572260
2020 During mitotic exit, Ki-67 molecular brushes collapse and promote chromosome clustering, which physically displaces large cytoplasmic components (including mature ribosomes) before nuclear envelope assembly, thereby re-establishing nuclear-cytoplasmic compartmentalization. This chromosome clustering function is microtubule-independent. Live-cell imaging, Ki-67 depletion/rescue, ribosome exclusion assays, HeLa cell manipulations Nature High 32879492
2018 Ki-67 and condensins support the structural integrity of mitotic chromosomes through independent yet cooperative mechanisms: Ki-67 localizes to the chromosome periphery while condensins occupy the central axis, and their localization/dynamics are mutually independent. Combined depletion of Ki-67 and SMC2 (condensin core subunit) produces a severe phenotype (ball-like chromosome clusters with no thread-like structures) distinct from either single depletion. Auxin-inducible degron conditional degradation, immunofluorescence, live-cell imaging in HCT116 cells Journal of cell science High 29487178
2006 Ki-67 physically associates with chromatin at the promoter and transcribed regions of the ribosomal RNA (rRNA) gene cluster, and a fraction of Ki-67 co-localizes with the rRNA transcription machinery during interphase and mitosis in proliferating cells; Ki-67 can also be detected at rRNA synthesis sites in quiescent cells, suggesting a role in early steps of rRNA synthesis. Chromatin immunoprecipitation (ChIP), immunofluorescence co-localization, novel antibody (TuBB-9) Journal of cellular physiology Medium 16206250
2022 By pA-DamID genome-wide mapping, Ki-67 associates with large late-replicating genomic domains during early interphase on all chromosomes but shifts toward small chromosomes later in interphase as it is confined to nucleoli. Ki-67 does not detectably control chromatin-chromatin interactions during interphase but competes with the nuclear lamina for interaction with late-replicating DNA and controls replication timing of (peri)centromeric regions. pA-DamID genomic mapping, nucleolar perturbation experiments, replication timing assays in human cell lines EMBO reports Medium 36245428
2024 Ki-67 plays a role during DNA replication: acute degradation of Ki-67 in HCT116 cells causes severe delay of DNA replication, unloading of the replication machinery, DNA damage not sensed by canonical pathways (dependent on HUWE1 ligase), defects in sister chromatid cohesion, and activation of the cGAS/STING interferon response. APEX2 proteomics identified the replication machinery as a Ki-67 proximal interactor. Doxycycline-inducible E3 ligase + auxin-inducible degron (rapid acute depletion), APEX2 proximity proteomics, phospho-proteomics, DNA fiber assays, immunofluorescence in HCT116 cells Genome biology High 38649976
2023 CCDC86 (cyclon) is a novel Ki-67-interacting protein at the chromosome periphery. CCDC86 depletion causes partial disorganisation of the chromosome periphery with altered localisation of Ki-67 and nucleolin, formation of abnormal cytoplasmic aggregates, errors in chromosome alignment, altered spindle length, and increased apoptosis. RNA interference, co-immunoprecipitation/pulldown, immunofluorescence microscopy, biochemical fractionation Journal of cell science Medium 36695333
2012 IRF1 represses Ki-67 gene transcription in a dose-dependent manner by decreasing endogenous Sp1 protein levels (without affecting Sp1 mRNA), thereby interfering with Sp1 activation of the Ki-67 core promoter. Mutation of two functional Sp1 binding sites in the Ki-67 core promoter abrogated Sp1-dependent enhancement of Ki-67 promoter activity. Promoter-reporter assays, site-directed mutagenesis of Sp1 binding sites, transfection/overexpression of IRF1, Western blot and qPCR for Sp1 levels Tumour biology Medium 22890831
2000 Ki-67 protein redistribution from the nuclear interior to the perichromosomal layer during mitosis is accompanied by posttranslational phosphorylation by cdc2 kinase and PKC. Phosphorylation assays, immunolocalization across cell cycle stages (review summarising experimental evidence from primary studies) Experimental cell research Low 10837136
2004 In early mouse embryos, Ki-67 protein shows cell-cycle-dependent redistribution: during mitosis it covers chromosome arms as part of the perichromosomal layer; in early G1 it distributes throughout the nucleus; for the remainder of interphase it associates with nucleolus precursor bodies (NPBs) or the nucleolus. This pattern is re-established after fertilization with a transition from minimal pronuclear expression to full somatic-type distribution by the 4-cell stage. Immunofluorescence and immunohistochemistry on staged mouse embryos across cell cycle phases Cytogenetic and genome research Low 15237214

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2000 The Ki-67 protein: from the known and the unknown. Journal of cellular physiology 3487 10653597
2018 Ki-67: more than a proliferation marker. Chromosoma 685 29322240
2002 The utility of Ki-67 and BrdU as proliferative markers of adult neurogenesis. Journal of neuroscience methods 654 11897369
2016 Ki-67 acts as a biological surfactant to disperse mitotic chromosomes. Nature 418 27362226
2019 Ki-67 protein as a tumour proliferation marker. Clinica chimica acta; international journal of clinical chemistry 354 30653951
2000 The Ki-67 protein: fascinating forms and an unknown function. Experimental cell research 314 10837136
2006 Ki-67 protein is associated with ribosomal RNA transcription in quiescent and proliferating cells. Journal of cellular physiology 306 16206250
2014 Ki-67 is a PP1-interacting protein that organises the mitotic chromosome periphery. eLife 160 24867636
2002 Correlation between MIB-1 and other proliferation markers: clinical implications of the MIB-1 cutoff value. Cancer 151 12001111
1995 p53 protein and Ki-67 reactivity in epithelial odontogenic lesions. An immunohistochemical study. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 126 8537911
1997 Ki-67 expression during rat liver regeneration after partial hepatectomy. Hepatology (Baltimore, Md.) 123 9303485
1999 Expression of steroid receptors, Ki-67, and p53 in uterine leiomyosarcomas. International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists 112 9891238
2009 Ki-67 in pituitary neoplasms: a review--part I. Neurosurgery 111 19687686
1991 Ki-67 immunostaining and survival in operable lung cancer. Histopathology 97 1664810
2022 Physiological functions and roles in cancer of the proliferation marker Ki-67. Journal of cell science 86 35674256
2021 The intrinsically disorderly story of Ki-67. Open biology 85 34375547
2020 Chromosome clustering by Ki-67 excludes cytoplasm during nuclear assembly. Nature 79 32879492
1995 Clinical relevance of Ki-67 expression in bone tumors. Cancer 79 7828130
2011 MicroRNA-519d targets MKi67 and suppresses cell growth in the hepatocellular carcinoma cell line QGY-7703. Cancer letters 65 21524841
1992 P53 and Ki-67 immunoreactivity in human prostate cancer and benign hyperplasia. British journal of urology 65 1379102
2017 MCM2: An alternative to Ki-67 for measuring breast cancer cell proliferation. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 62 28084344
2017 Ki-67 and the Chromosome Periphery Compartment in Mitosis. Trends in cell biology 59 28838621
2007 Cell membrane reactivity of MIB-1 antibody to Ki67 in human tumors: fact or artifact? Applied immunohistochemistry & molecular morphology : AIMM 57 17525638
2004 Expression of Melan-A and Ki-67 in desmoplastic melanoma and desmoplastic nevi. The American Journal of dermatopathology 57 15618925
2016 The Ki-67 and RepoMan mitotic phosphatases assemble via an identical, yet novel mechanism. eLife 55 27572260
1999 Expression of P27kip1 and Ki-67 in pituitary adenomas: an investigation of marker of adenoma invasiveness. Acta neurochirurgica 52 10189502
2019 Ki-67/MKI67 as a Predictive Biomarker for Clinical Outcome in Gastric Cancer Patients: an Updated Meta-analysis and Systematic Review involving 53 Studies and 7078 Patients. Journal of Cancer 46 31632479
2005 Utility of cytokeratin 20 and Ki-67 as markers of urothelial dysplasia. Pathology international 46 15871722
2018 Ki-67 and condensins support the integrity of mitotic chromosomes through distinct mechanisms. Journal of cell science 45 29487178
2018 Comparison of central laboratory assessments of ER, PR, HER2, and Ki67 by IHC/FISH and the corresponding mRNAs (ESR1, PGR, ERBB2, and MKi67) by RT-qPCR on an automated, broadly deployed diagnostic platform. Breast cancer research and treatment 44 30120700
2015 Significance of p53 and ki-67 expression in prostate cancer. Urology annals 42 26692671
2018 Ki-67 labeling index in glioblastoma; does it really matter? Hematology/oncology and stem cell therapy 40 30552865
2001 Tumour angiogenesis and Ki-67 expression in phaeochromocytoma. BJU international 38 11251535
2016 All-Trans Retinoic Acid Modulates DNA Damage Response and the Expression of the VEGF-A and MKI67 Genes in ARPE-19 Cells Subjected to Oxidative Stress. International journal of molecular sciences 37 27314326
2013 Expression of Ki-67 and p53 in meningiomas. Neoplasma 37 23790165
2022 Lung carcinoid tumours: histology and Ki-67, the eternal rivalry. Histopathology 36 36239545
2006 Expression of cyclooxygenase-2, p53 and Ki-67 in gastric cancer. Journal of Korean medical science 36 17043422
2024 Ki-67 is necessary during DNA replication for fork protection and genome stability. Genome biology 31 38649976
2002 p53 protein and Ki-67 overexpression in urothelial dysplasia of bladder. Applied immunohistochemistry & molecular morphology : AIMM 31 12607601
2018 Expression and significance of Ki-67 in lung cancer. Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie 30 29940632
2017 Parafibromin, APC, and MIB-1 Are Useful Markers for Distinguishing Parathyroid Carcinomas From Adenomas. Applied immunohistochemistry & molecular morphology : AIMM 30 27490759
1998 Bcl-2, p53 and MIB-1 expression in normal and neoplastic parathyroid tissues. Journal of endocrinological investigation 29 9591207
2019 An oncogenic gene, SNRPA1, regulates PIK3R1, VEGFC, MKI67, CDK1 and other genes in colorectal cancer. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 28 31203132
1994 Ki-67 expression in vulvar carcinoma. International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists 27 7928052
2022 Dynamic chromosomal interactions and control of heterochromatin positioning by Ki-67. EMBO reports 23 36245428
2006 Galectin-3 and Ki-67 expression in multiglandular parathyroid lesions. American journal of clinical pathology 22 16753595
2005 MIB-1 and PCNA immunostaining as a diagnostic adjunct to cervical Pap smear. Diagnostic cytopathology 21 15945082
2019 Immunohistochemical expression of P53, Ki-67, and CD34 in psoriasis and psoriasiform dermatitis. BioMedicine 20 31724940
2015 Ki-67 and p53 immunostaining assessment of proliferative activity in salivary tumors. Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie 20 26743291
2007 Histological grading and MIB-1 labeling index of soft-tissue sarcomas. Pathology international 20 17295643
2004 Expression of the proliferation marker Ki-67 during early mouse development. Cytogenetic and genome research 20 15237214
1996 Assessment of p53 and Ki-67 expression in snuff-induced lesions. The British journal of oral & maxillofacial surgery 20 8909732
2012 Ki-67 expression predicts radiotherapy failure in early glottic cancer. Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale 19 22569013
2014 Expression of cyclinD1 and Ki-67 proteins in gliomas and its clinical significance. European review for medical and pharmacological sciences 18 24610618
1995 Expression of p53 protein, PCNA, and Ki-67 in osteosarcomas of bone. Journal of Korean medical science 18 8750062
2016 The role of Ki-67 in breast cancer. South African journal of surgery. Suid-Afrikaanse tydskrif vir chirurgie 17 28240498
2015 P63 and Ki-67 Expression in Dentigerous Cyst and Ameloblastomas. Journal of dentistry (Shiraz, Iran) 17 26636120
2007 Utility of SKP2 and MIB-1 in grading follicular lymphoma using quantitative imaging analysis. Human pathology 17 17350668
2018 Ki-67 and Survivin as Predictive Factors for Rectal Cancer Treated with Preoperative Chemoradiotherapy. Anticancer research 16 29491110
2014 The significance of immunohistochemical expression of merlin, Ki-67, and p53 in meningiomas. Applied immunohistochemistry & molecular morphology : AIMM 16 23455188
2021 ESR1, PGR, ERBB2, and MKi67 mRNA expression in postmenopausal women with hormone receptor-positive early breast cancer: results from ABCSG Trial 6. ESMO open 15 34371382
2020 STMN1 and MKI67 Are Upregulated in Uterine Leiomyosarcoma and Are Potential Biomarkers for its Diagnosis. Medical science monitor : international medical journal of experimental and clinical research 15 32425177
2023 Low expression of Ki-67/MIB-1 labeling index in IDH wild type glioblastoma predicts prolonged survival independently by MGMT methylation status. Journal of neuro-oncology 14 37227648
2022 The Biomarker Ki-67: Promise, Potential, and Problems in Breast Cancer. Applied immunohistochemistry & molecular morphology : AIMM 14 36730064
2011 Frequency of Ki-67 (MIB-1) and P53 expressions among patients with prostate cancer. Indian journal of pathology & microbiology 14 22234091
2002 MIB-1 expression in cervical Papanicolaou tests correlates with dysplasia in subsequent cervical biopsies. Applied immunohistochemistry & molecular morphology : AIMM 14 11893030
2023 The Expression of Testin, Ki-67 and p16 in Cervical Cancer Diagnostics. Current issues in molecular biology 13 36661518
2016 The expression and significance of p53 protein and Ki-67 protein in pterygium. Vojnosanitetski pregled 13 26964379
2016 Survivin, caspase-3 and MIB-1 expression in astrocytic tumors of various grades. Advances in medical sciences 13 26995334
2014 Characterizing invading glioma cells based on IDH1-R132H and Ki-67 immunofluorescence. Brain tumor pathology 13 24384677
2021 Chromosome clustering in mitosis by the nuclear protein Ki-67. Biochemical Society transactions 12 34783345
2014 Expression of Ki-67, Bax and p73 in patients with hilar cholangiocarcinoma. Cancer biomarkers : section A of Disease markers 12 24934361
2017 Role of p53 and Ki-67 immunomarkers in carcinoma of urinary bladder. Indian journal of pathology & microbiology 11 29323062
2016 Expression of SATB1, MTI/II and Ki-67 in Mycosis Fungoides. Anticancer research 11 26722043
2016 PTTG and Ki-67 expression in pituitary adenomas. Przeglad lekarski 11 27197423
2012 Usefulness of Ki-67 (MIB-1) immunostaining in the diagnosis of pulmonary sclerosing hemangiomas. APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 11 23030396
2009 P63 and Ki-67 expression in trophoblastic disease and spontaneous abortion. Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences 11 21772911
1989 Ki-67 labeling index in breast cancer. Tumori 11 2694554
2020 Maspin, Syndecan-1, and Ki-67 in the Odontogenic Keratocyst: An Immunohistochemical Analysis. International journal of dentistry 10 32733563
2019 Elevated Ki-67 (MIB-1) expression as an independent predictor for unfavorable pathologic outcomes and biochemical recurrence after radical prostatectomy in patients with localized prostate cancer: A propensity score matched study. PloS one 10 31697718
2018 ki-67 and Topoisomerase IIa proliferation markers in colon adenocarcinoma. Journal of B.U.ON. : official journal of the Balkan Union of Oncology 10 30722108
2016 Expression of Mcl-1 and Ki-67 in Papillary Thyroid Carcinomas. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 10 27123780
2016 Ki-67 is overexpressed in human laryngeal carcinoma and contributes to the proliferation of HEp2 cells. Oncology letters 10 27703526
2012 Immunohistochemical evaluation of p53 and Ki-67 proteins in colorectal adenomas. Arquivos de gastroenterologia 10 22481684
2012 IRF1 suppresses Ki-67 promoter activity through interfering with Sp1 activation. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 10 22890831
2012 Expression of Ki-67 (MIB-1) and GLUT-1 proteins in non-advanced prostatic cancer. Polish journal of pathology : official journal of the Polish Society of Pathologists 10 23359198
2010 P16INK4A and MIB-1: an immunohistochemical expression in preneoplasia and neoplasia of the cervix. Indian journal of pathology & microbiology 10 20699515
2002 Expression of Ki-67 and PCNA as proliferating markers in prostate cancer. Roczniki Akademii Medycznej w Bialymstoku (1995) 10 12533969
2023 CCDC86 is a novel Ki-67-interacting protein important for cell division. Journal of cell science 9 36695333
2013 Ki-67 expression in hydatidiform moles and hydropic abortions. Iranian Red Crescent medical journal 9 24396579
2005 Clinical features and immunoexpression of p53, MIB-1 and proliferating cell nuclear antigen in adrenal neoplasms. The Journal of urology 9 15879867
2001 Clinicopathologic study of retinoblastoma including MIB-1, p53, and CD99 immunohistochemistry. Annals of diagnostic pathology 9 11436168
2000 bcl-2, p53, and MIB-1 in human adult dental pulp. Journal of endodontics 9 11199723
2022 Double Ki-67 and synaptophysin labeling in pancreatic neuroendocrine tumor biopsies. Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 8 35292233
2022 MKI67 as a potential diagnostic biomarker in pulmonary hypertension. Frontiers in pediatrics 8 36389368
2021 Hepatoma upregulated protein and Ki-67 expression in resectable hepatocellular carcinoma. Journal of the Chinese Medical Association : JCMA 8 33883465
2020 Consecutive Hypoxia Decreases Expression of NOTCH3, HEY1, CC10, and FOXJ1 via NKX2-1 Downregulation and Intermittent Hypoxia-Reoxygenation Increases Expression of BMP4, NOTCH1, MKI67, OCT4, and MUC5AC via HIF1A Upregulation in Human Bronchial Epithelial Cells. Frontiers in cell and developmental biology 8 33015064
2018 MIB-1 Is Required for Spermatogenesis and Facilitates LIN-12 and GLP-1 Activity in Caenorhabditis elegans. Genetics 8 29531012
2017 Expression of FOXC2, PinX1, Ki-67 and Cyclin D1 in cutaneous cell carcinoma. Oncology letters 8 28693215
2012 Correlation of p53 and KI-67 expression with grade and subtype of ependymoma. Indian journal of pathology & microbiology 8 23032822

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