Affinage

SMC2

Structural maintenance of chromosomes protein 2 · UniProt O95347

Round 2 corrected
Length
1197 aa
Mass
135.7 kDa
Annotated
2026-04-28
57 papers in source corpus 16 papers cited in narrative 16 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

SMC2 is the shared core ATPase subunit of the condensin I and condensin II complexes, essential for mitotic and meiotic chromosome condensation and segregation across eukaryotes. SMC2 forms an obligate heterodimer with SMC4 whose ATPase activity requires both subunits; the dimer binds DNA and introduces geometric compaction detected as chiral knotting, with the coiled-coil arms adopting highly flexible, dynamically interconverting conformations coupled to the nucleotide hydrolysis cycle (PMID:12719426, PMID:16100111, PMID:26904946). Condensin II activity during interphase is restrained by MCPH1, which blocks the SMC2–kleisin (NCAPH2) interface, while AURKA phosphorylation of SMC2 at T574 disrupts SMC2/SMC4 binding and chromosomal association when peri-chromosomal pre-rRNAs are depleted (PMID:34850681, PMID:41203590). Maternal SMC2 is required for one-cell-stage embryonic viability in mice, and condensin II-dependent SMC2 function is essential for hematopoietic stem cell maintenance in zebrafish (PMID:37642322, PMID:40134128).

Mechanistic history

Synthesis pass · year-by-year structured walk · 12 steps
  1. 1995 High

    Identification of SMC2 as an essential chromosome condensation/segregation factor established that the SMC family includes a dedicated condensin subgroup distinct from cohesin components.

    Evidence Temperature-sensitive smc2-6 mutant in S. cerevisiae with co-immunoprecipitation and nuclear localization

    PMID:7698648

    Open questions at the time
    • Binding partners in the condensation machinery were unknown
    • Whether SMC2 acts as a homodimer or heterodimer was unresolved
  2. 2000 High

    Demonstration that human SMC2 and SMC4 form a heterodimer that associates with non-SMC subunits to compose a mitosis-specific condensin complex resolved the subunit architecture of vertebrate condensin.

    Evidence Reciprocal co-immunoprecipitation from HeLa extracts, subcellular fractionation, and cell-cycle-staged immunofluorescence

    PMID:10958694

    Open questions at the time
    • Whether additional condensin variants existed was unknown
    • Mechanism of mitosis-specific chromosome targeting was unresolved
  3. 2003 High

    Biochemical reconstitution showed that ATPase activity requires the SMC2/SMC4 heterodimer and that the dimer binds DNA and introduces geometric compaction, providing the first mechanistic model for how condensin reshapes DNA topology.

    Evidence In vitro ATPase assays, DNA binding and topoisomerase-trapping knotting assays with purified yeast Smc2/4

    PMID:12719426

    Open questions at the time
    • Role of ATP hydrolysis versus binding in DNA compaction was unclear
    • Contribution of non-SMC subunits to the compaction mechanism was not addressed
  4. 2003 High

    Discovery that SMC2 is the shared core subunit of two non-redundant condensin complexes (I and II) with distinct chromosomal distributions resolved how a single heterodimer serves parallel condensation pathways.

    Evidence siRNA depletion of condensin I- versus II-specific subunits in HeLa cells and Xenopus egg extracts, with distinct chromosome morphology phenotypes

    PMID:14532007

    Open questions at the time
    • Mechanism specifying condensin I versus II loading onto chromosomes was unknown
    • How SMC2 is partitioned between the two complexes was not determined
  5. 2005 High

    Demonstration that the Smc2/4 dimer promotes chiral DNA knotting independently of ATP hydrolysis or non-SMC subunits indicated that the SMC backbone itself possesses an intrinsic DNA-organizing activity.

    Evidence In vitro knotting assays with ATPase-dead Smc2/4 mutant, electron microscopy of protein–DNA filaments and rings

    PMID:16100111

    Open questions at the time
    • How ATP hydrolysis contributes to loop extrusion in vivo remained unresolved
    • Structural basis for chiral selectivity was not determined
  6. 2015 Medium

    Cross-linking mass spectrometry of condensin I revealed that the SMC2/SMC4 coiled coils can be closely apposed along their length in both isolation and on mitotic chromosomes, constraining three-dimensional models of the condensin architecture.

    Evidence Amino acid-selective cross-linking MS and homology modelling of chicken condensin I

    PMID:25716199

    Open questions at the time
    • No mutagenesis validation of predicted inter-arm contacts
    • Dynamics of coiled-coil apposition during the ATPase cycle were not captured
  7. 2016 High

    High-speed AFM imaging revealed that Smc2/4 coiled coils are highly flexible (~4 nm persistence length) and that their conformations interconvert dynamically, with head–hinge contacts possible, fundamentally changing the view of condensin as a rigid rod.

    Evidence High-speed AFM in liquid of purified Smc2/4 dimers

    PMID:26904946

    Open questions at the time
    • How flexibility is modulated by nucleotide state was not resolved at this stage
    • Relationship between observed conformational dynamics and DNA loop extrusion was not addressed
  8. 2012 Medium

    Identification of WNT/β-catenin·TCF4 as a direct transcriptional activator of SMC2 linked condensin expression to a major oncogenic signaling pathway and provided a mechanism for elevated SMC2 in intestinal tumors.

    Evidence ChIP/reporter assay on SMC2 promoter, siRNA knockdown with in vivo xenograft proliferation readout

    PMID:23095742

    Open questions at the time
    • Whether WNT-driven SMC2 upregulation is rate-limiting for condensin complex assembly was not tested
    • Generalizability beyond intestinal tumor context is unknown
  9. 2021 High

    Elucidation of MCPH1 as an interphase inhibitor of condensin II acting through the SMC2–kleisin interface established a cohesin-WAPL–analogous gating mechanism for condensin regulation and explained how premature chromosome condensation is prevented.

    Evidence Conditional Mcph1 knockout in mouse ESCs, Hi-C, CDK1 inhibition, SMC2–NCAPH2 fusion rescue constructs

    PMID:34850681

    Open questions at the time
    • Whether MCPH1 regulation operates identically in all cell types is untested
    • Structural basis of MCPH1 binding at the SMC2–kleisin interface is unresolved
  10. 2023 High

    Oocyte-specific conditional knockout of SMC2 proved that maternal condensin is essential for chromosome condensation in meiosis and for one-cell embryo viability, directly linking SMC2 to fertility and early development.

    Evidence Oocyte-specific Cre/lox SMC2 knockout in mice, live imaging, DNA damage and pronuclear morphology analysis

    PMID:37642322

    Open questions at the time
    • Relative contributions of condensin I versus II in the oocyte are not distinguished
    • Whether paternal SMC2 can partially rescue at later stages is unknown
  11. 2024 High

    Discovery that AURKA phosphorylates SMC2 at T574 to disrupt SMC2/SMC4 binding when pre-rRNAs are depleted revealed a mitotic quality-control mechanism coupling ribosomal RNA status to chromosome structural integrity.

    Evidence In vitro kinase assay, phospho-specific antibody, co-IP, mass spectrometry, T574A mutant rescue of mitotic catastrophe

    PMID:41203590

    Open questions at the time
    • How pre-rRNAs physically shield T574 from AURKA access is unclear
    • Whether other kinases also target this site in different stress contexts is unexplored
  12. 2025 Medium

    Genetic dissection in zebrafish demonstrated that SMC2's role in hematopoietic stem cell maintenance is condensin II-specific, revealing tissue-selective reliance on a particular condensin complex.

    Evidence CRISPR knockouts of smc2 and individual condensin I versus II subunits in zebrafish, cell cycle analysis

    PMID:40134128

    Open questions at the time
    • Molecular basis for condensin II selectivity in HSPCs versus other tissues is unknown
    • Whether this reflects differential condensin expression or function is unresolved

Open questions

Synthesis pass · forward-looking unresolved questions
  • The full mechanochemical cycle coupling ATP hydrolysis to DNA loop extrusion by condensin remains structurally unresolved at atomic resolution, and the signals partitioning SMC2 between condensin I and condensin II in vivo are unknown.
  • No high-resolution cryo-EM structure of full-length condensin actively translocating on DNA
  • Mechanism determining condensin I versus II stoichiometry is uncharacterized
  • Whether SMC2 post-translational modifications beyond T574 regulate complex choice is unexplored

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0005198 structural molecule activity 3 GO:0140657 ATP-dependent activity 3 GO:0003677 DNA binding 2
Localization
GO:0005694 chromosome 5 GO:0005634 nucleus 2
Pathway
R-HSA-1640170 Cell Cycle 4 R-HSA-4839726 Chromatin organization 4
Partners
AURKAMCPH1NCAPD2NCAPG2NCAPH2SMC4
Complex memberships
condensin Icondensin II

Evidence

Reading pass · 16 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1995 SMC2 (Smc2p) is a 135-kDa nuclear protein in S. cerevisiae essential for chromosome segregation and condensation. The temperature-sensitive smc2-6 mutation causes chromosome segregation defects and partial chromosome decondensation in mitosis. Smc2p forms complexes in vivo with both Smc1p and itself, indicating it assembles into multimeric structures. SMC2 defines a distinct subgroup within the SMC family that includes ScII, XCAPE, and cut14 proteins. Genetic analysis (temperature-sensitive mutant), co-immunoprecipitation, cellular fractionation/nuclear localization, electron microscopy Genes & development High 7698648
2000 Human hCAP-C (SMC4) and hCAP-E (SMC2) form a heterodimeric complex that associates with a 155-kDa non-SMC subunit CNAP1 (homolog of XCAP-D2) to form a human condensin complex. Chromosome association of human condensin is mitosis-specific, with the majority sequestered in the cytoplasm during interphase. A subpopulation remains on chromosomes as foci in interphase nuclei, and during late G2/early prophase, nuclear condensin foci colocalize with phosphorylated histone H3 on partially condensed chromosome regions. Co-immunoprecipitation from HeLa extracts, subcellular fractionation, immunofluorescence localization, cell-cycle staging Molecular and cellular biology High 10958694
2003 The yeast Smc2p-Smc4p heterodimer forms a stable heterodimer that self-associates into heterotetramers. Neither Smc2p nor Smc4p alone hydrolyzes ATP, but mixing equimolar amounts recovers ATPase activity. The Smc2/4 complex binds both linear and circular DNA independently of adenylate nucleotide, and at high molar ratios promotes geometric changes in circular DNA that are trapped as knots by type II topoisomerases (but not supercoils by type I topoisomerase), suggesting simultaneous capture of two DNA duplexes. Sedimentation equilibrium, in vitro ATPase assay, DNA binding/topoisomerase trapping assays, competition-displacement experiments The Journal of biological chemistry High 12719426
2003 Human SMC2 is a shared core subunit of two distinct condensin complexes (condensin I and condensin II) in vertebrate cells. Condensins I and II share the SMC2/SMC4 heterodimer but contain different sets of non-SMC subunits. siRNA depletion of condensin I- or condensin II-specific subunits produces distinct, characteristic chromosome morphology defects, and simultaneous depletion causes the severest defects, demonstrating non-redundant functions. The two complexes show different distributions along the chromosome axis. siRNA knockdown, immunofluorescence, chromosome morphology analysis in HeLa cells, Xenopus egg extract reconstitution Cell High 14532007
2005 The S. cerevisiae Smc2/4 dimer promotes (+) chiral knotting of nicked plasmids via a mechanism that requires neither ATP hydrolysis nor non-SMC condensin subunits, as demonstrated by ATPase-dead mutant Smc2/4 showing identical chiral knotting to wild-type. Smc2/4 does not induce net supercoiling but broadens topoisomer distributions cooperatively. At high stoichiometries, Smc2/4 prevents relaxation by topoisomerase I and nick closure by ligase. Electron microscopy reveals Smc2/4–DNA complexes form long flexible filaments and uniform ring/doughnut structures. In vitro topoisomerase knotting/linking assay, ATPase mutant analysis, electron microscopy of protein-DNA complexes, topoisomerase protection assays The Journal of biological chemistry High 16100111
2012 SMC2 transcription is directly activated by the WNT signaling pathway through binding of the β-catenin·TCF4 transcription factor to the SMC2 promoter. A specific promoter region required for β-catenin-mediated activation was identified. SMC2 siRNA knockdown in WNT-activated intestinal tumor cells significantly reduced cell proliferation in nude mice. Promoter binding assay (ChIP/reporter), siRNA knockdown, in vivo xenograft model The Journal of biological chemistry Medium 23095742
2015 Cross-linking mass spectrometry combined with molecular modelling revealed the three-dimensional topology of the SMC2/SMC4 dimeric backbone of chicken condensin I. The isolated complex can exist with coiled-coil segments closely apposed along their lengths, and the centers of coiled-coils can also approach each other closely in situ in mitotic chromosomes. Cross-linking data also suggest that histone H2A and H4 may mediate condensin interactions with chromatin. Amino acid-selective cross-linking mass spectrometry, homology-based molecular modelling, structural prediction Open biology Medium 25716199
2016 High-speed atomic force microscopy (AFM) in liquid revealed that Smc2-Smc4 coiled coils are highly flexible polymers with a persistence length of only ~4 nm. The SMC dimers adopt various architectures that interconvert dynamically over time. SMC head domains engage not only with each other (at the head-head interface) but also with the hinge domain at the opposite end of the ~45-nm coiled coil. High-speed atomic force microscopy (AFM) in liquid Cell reports High 26904946
2014 SMC2 transcription is regulated by MYCN in neuroblastoma cells. SMC2 also transcriptionally regulates DNA damage response genes in cooperation with MYCN. Downregulation of SMC2 induced DNA damage and showed a synergistic lethal response selectively in MYCN-amplified/overexpressing neuroblastoma cells, leading to apoptosis. siRNA knockdown, gene expression analysis, apoptosis assays, DNA damage markers Cell cycle (Georgetown, Tex.) Medium 24553121
2021 MCPH1 inhibits condensin II activity during interphase by binding via a short linear motif to the condensin II-specific NCAPG2 subunit, blocking condensin II's association with chromatin. Deletion of Mcph1 in mouse embryonic stem cells unleashes condensin II activity, causing compact chromosome formation in G1 and G2 even without CDK1 activity, with enhanced mixing of A and B chromatin compartments. The inhibitory mechanism requires the SMC2-NCAPH2 (kleisin) interface: fusion of SMC2 with NCAPH2 abrogates MCPH1's ability to block condensin II chromatin association, analogous to WAPL's regulation of cohesin via the SMC3-kleisin interface. Conditional knockout (mouse ESCs), Hi-C chromatin conformation, CDK1 inhibition, genetic fusion constructs, chromatin fractionation eLife High 34850681
2017 Nesprin-2, a nuclear envelope protein, interacts with SMC2 and SMC4 (core condensin subunits) via its SMC-like rod domain (aa 1436–1766). This interaction occurs throughout the cell cycle and is particularly strong during S phase, persisting into mitosis. Nesprin-2 knockdown increases chromatin bridge formation in anaphase, suggesting a functional link. Co-immunoprecipitation, domain mapping, knockdown with anaphase chromatin bridge quantification International journal of cell biology Medium 29445399
2021 SMC2 depletion in zebrafish (CRISPR knockout) leads to a small liver phenotype through extensive p53-dependent apoptosis in liver cells caused by defective chromosome segregation and subsequent DNA damage. Hepatoblast specification was unaffected, indicating SMC2 is required post-specification for hepatocyte survival via maintaining chromosome integrity. CRISPR/Cas9 knockout, morphological analysis, apoptosis assays, p53 pathway analysis in zebrafish Biomedicines Medium 34572426
2023 Oocyte-specific conditional knockout of SMC2 in mice causes female infertility. In the absence of SMC2, oocyte meiotic maturation and ovulation occur normally, but chromosome condensation is defective and DNA damage accumulates in oocytes. Fertilized eggs show abnormal pronuclear organization and frequent micronuclei, with embryo development arrested at the one-cell stage, demonstrating that maternal SMC2 is essential for embryonic development through chromosome condensation. Oocyte-specific conditional knockout mouse model, live imaging, immunofluorescence, DNA damage markers Journal of cellular physiology High 37642322
2024 AURKA phosphorylates SMC2 at T574 (within the consensus R/K/N-R-X-S/T-B motif) when RNA Polymerase I transcription is inhibited and pre-rRNAs are depleted from the peri-chromosomal region. This phosphorylation disrupts SMC2/SMC4 binding and their association with chromosomal DNA, leading to chromosomal segregation defects and mitotic catastrophe. A phosphorylation-deficient SMC2 T574A mutant rescues the mitotic catastrophe caused by Pol I inhibition. Under normal conditions, pre-rRNAs protect SMC2 from AURKA-mediated phosphorylation. In vitro kinase assay, phospho-specific antibody generation, co-immunoprecipitation, quantitative proteomics/mass spectrometry, chromosome isolation, SMC2 T574A mutant rescue Cell death & disease High 41203590
2025 In zebrafish, smc2 loss-of-function (CRISPR) causes G2/M cell cycle arrest in hematopoietic stem and progenitor cells (HSPCs), leading to their maintenance and expansion failure. Condensin II subunits (ncaph2, ncapg2, ncapd3) were essential for HSPC maintenance, whereas condensin I subunits did not affect HSPC development, indicating a condensin II-specific role for SMC2 in hematopoiesis. CRISPR loss-of-function zebrafish mutants, cell cycle analysis, functional genetic dissection of condensin I vs. II subunits Journal of cellular physiology Medium 40134128
2025 Solution AFM imaging combined with coarse-grained molecular dynamics simulations of the yeast Smc2/4 heterodimer revealed that ATP binding (head engagement) is coupled to hinge domain opening, while ADP release is followed by re-association of the N-terminal region of the kleisin Brn1 to the Smc2 head. Different nucleotide states (AMP-PNP, ATPγS, ADP, apo) produce distinct Smc2/4 conformations, providing a structural model of condensin's mechanochemical cycle. Solution atomic force microscopy (AFM), coarse-grained molecular dynamics simulation bioRxivpreprint Medium bio_10.1101_2024.12.16.628603

Source papers

Stage 0 corpus · 57 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America 1479 12477932
2015 The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell 1118 26186194
2017 Architecture of the human interactome defines protein communities and disease networks. Nature 1085 28514442
2015 A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell 1015 26496610
2005 Nucleolar proteome dynamics. Nature 934 15635413
2018 VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell discovery 829 29507755
2003 Complete sequencing and characterization of 21,243 full-length human cDNAs. Nature genetics 754 14702039
2007 Large-scale mapping of human protein-protein interactions by mass spectrometry. Molecular systems biology 733 17353931
2021 Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Cell 705 33961781
2012 A census of human soluble protein complexes. Cell 689 22939629
2011 Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Briefings in bioinformatics 656 21873635
2008 Large-scale proteomics and phosphoproteomics of urinary exosomes. Journal of the American Society of Nephrology : JASN 607 19056867
2006 Wapl controls the dynamic association of cohesin with chromatin. Cell 498 17113138
2003 Differential contributions of condensin I and condensin II to mitotic chromosome architecture in vertebrate cells. Cell 460 14532007
2015 A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. Cell 433 26638075
2022 OpenCell: Endogenous tagging for the cartography of human cellular organization. Science (New York, N.Y.) 432 35271311
2015 Panorama of ancient metazoan macromolecular complexes. Nature 407 26344197
2015 Proteome-wide profiling of protein assemblies by cross-linking mass spectrometry. Nature methods 370 26414014
2006 Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia. Molecular psychiatry 345 17043677
2021 A proximity-dependent biotinylation map of a human cell. Nature 339 34079125
1995 SMC2, a Saccharomyces cerevisiae gene essential for chromosome segregation and condensation, defines a subgroup within the SMC family. Genes & development 298 7698648
2012 A high-throughput approach for measuring temporal changes in the interactome. Nature methods 273 22863883
2013 The bromodomain protein Brd4 insulates chromatin from DNA damage signalling. Nature 269 23728299
2018 K63 ubiquitylation triggers proteasomal degradation by seeding branched ubiquitin chains. Proceedings of the National Academy of Sciences of the United States of America 227 29378950
2017 Optimized fragmentation schemes and data analysis strategies for proteome-wide cross-link identification. Nature communications 221 28524877
2016 An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. Nature communications 211 27173435
2011 Toward an understanding of the protein interaction network of the human liver. Molecular systems biology 207 21988832
2013 PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry. Molecular cell 204 24332808
2018 An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations. Nature communications 201 29568061
2017 The E3 ubiquitin ligase and RNA-binding protein ZNF598 orchestrates ribosome quality control of premature polyadenylated mRNAs. Nature communications 176 28685749
2020 UFMylation maintains tumour suppressor p53 stability by antagonizing its ubiquitination. Nature cell biology 168 32807901
2000 A human condensin complex containing hCAP-C-hCAP-E and CNAP1, a homolog of Xenopus XCAP-D2, colocalizes with phosphorylated histone H3 during the early stage of mitotic chromosome condensation. Molecular and cellular biology 102 10958694
2016 Condensin Smc2-Smc4 Dimers Are Flexible and Dynamic. Cell reports 70 26904946
2007 Autologous transplantation of SM/C-2.6(+) satellite cells transduced with micro-dystrophin CS1 cDNA by lentiviral vector into mdx mice. Molecular therapy : the journal of the American Society of Gene Therapy 68 17726457
2014 Bovine exome sequence analysis and targeted SNP genotyping of recessive fertility defects BH1, HH2, and HH3 reveal a putative causative mutation in SMC2 for HH3. PloS one 58 24667746
2003 Biochemical analysis of the yeast condensin Smc2/4 complex: an ATPase that promotes knotting of circular DNA. The Journal of biological chemistry 56 12719426
2012 Human SMC2 protein, a core subunit of human condensin complex, is a novel transcriptional target of the WNT signaling pathway and a new therapeutic target. The Journal of biological chemistry 47 23095742
2015 Three-dimensional topology of the SMC2/SMC4 subcomplex from chicken condensin I revealed by cross-linking and molecular modelling. Open biology 45 25716199
2021 MCPH1 inhibits Condensin II during interphase by regulating its SMC2-Kleisin interface. eLife 41 34850681
2005 The Saccharomyces cerevisiae Smc2/4 condensin compacts DNA into (+) chiral structures without net supercoiling. The Journal of biological chemistry 41 16100111
2014 Inactivation of SMC2 shows a synergistic lethal response in MYCN-amplified neuroblastoma cells. Cell cycle (Georgetown, Tex.) 31 24553121
2020 Plasmodium Condensin Core Subunits SMC2/SMC4 Mediate Atypical Mitosis and Are Essential for Parasite Proliferation and Transmission. Cell reports 29 32049018
2019 Potential functional variants in SMC2 and TP53 in the AURORA pathway genes and risk of pancreatic cancer. Carcinogenesis 24 30794721
2020 Intracellular Delivery of Anti-SMC2 Antibodies against Cancer Stem Cells. Pharmaceutics 23 32098204
2014 Mutational and expressional analysis of SMC2 gene in gastric and colorectal cancers with microsatellite instability. APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 13 24483990
2010 Streptavidin-Binding Peptide (SBP)-tagged SMC2 allows single-step affinity fluorescence, blotting or purification of the condensin complex. BMC biochemistry 12 21194474
2020 The condensin subunits SMC2 and SMC4 interact for correct condensation and segregation of mitotic maize chromosomes. The Plant journal : for cell and molecular biology 9 31816133
2024 TDMPP activation of estrogen receptor 2a regulates smc2 and p53 signaling to interfere with liver development in zebrafish (Danio rerio). Journal of hazardous materials 5 39096633
2021 Functions of SMC2 in the Development of Zebrafish Liver. Biomedicines 5 34572426
2024 SMC2 ablation impairs bovine embryo development shortly after blastocyst hatching. Reproduction (Cambridge, England) 3 39231091
2017 Nesprin-2 Interacts with Condensin Component SMC2. International journal of cell biology 3 29445399
2024 SMC2 knockdown inhibits malignant progression of lung adenocarcinoma by upregulating BTG2 expression. Cellular signalling 2 38729325
2010 Cloning, expression, crystallization and preliminary X-ray crystallographic analysis of a human condensin SMC2 hinge domain with short coiled coils. Acta crystallographica. Section F, Structural biology and crystallization communications 2 20823528
2023 Maternal SMC2 is essential for embryonic development via participating chromosome condensation in mice. Journal of cellular physiology 1 37642322
2025 SMC2 and Condensin II Subunits Are Essential for the Development of Hematopoietic Stem and Progenitor Cells in Zebrafish. Journal of cellular physiology 0 40134128
2025 Deciphering Plasmodium Condensin Core Subunits of Structural Maintenance of Chromosomes 2 (SMC2) as a Putative Drug Target for Antimalarial Drug. Recent advances in anti-infective drug discovery 0 40356391
2025 Pre-rRNAs control mitosis by maintaining chromosomal segregation through protecting SMC2 from AURKA-mediated phosphorylation. Cell death & disease 0 41203590