Affinage

HOXA10

Homeobox protein Hox-A10 · UniProt P31260

Length
410 aa
Mass
42.4 kDa
Annotated
2026-06-10
100 papers in source corpus 39 papers cited in narrative 39 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 8/8 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

HOXA10 is a homeodomain transcription factor that establishes positional identity and orchestrates lineage-specific differentiation programs, with foundational genetic evidence linking it to skeletal patterning, male and female fertility, and embryo implantation (PMID:7700356, PMID:10981664). It acts as a sequence-specific DNA-binding regulator that can either activate or repress target promoters depending on cofactor context and post-translational state. Its DNA-binding activity is controlled by tyrosine phosphorylation of the homeodomain: the phosphatases SHP1 and SHP2 dephosphorylate HOXA10 to sustain a DNA-binding-competent repressor state, while IFN-γ-induced phosphorylation lowers affinity and relieves repression (PMID:12145285, PMID:17138561, PMID:16210632). PCAF acetylates HOXA10 at K338/K339 to impair its transcriptional activation of targets such as ITGB3 (PMID:24037888). In myeloid progenitors, HOXA10 represses the phagocyte oxidase genes CYBB and NCF2 by recruiting HDAC2 through a Pbx1-independent repression domain, while activating FGF2, CDX4, ARIH2/Triad1, and DUSP4 to drive progenitor expansion, autocrine FGF2/PI3K/β-catenin signaling, and the timely termination of emergency granulopoiesis (PMID:14512427, PMID:21454682, PMID:21471217, PMID:22493287, PMID:23038246, PMID:25895533), and it governs hematopoietic stem cell self-renewal in a dose-dependent manner (PMID:17234739). In endometrium, HOXA10 directly activates ITGB3 and E-cadherin and represses KLF9 and IGFBP1, working with the cofactor MEIS1 to regulate receptivity, implantation, and decidualization (PMID:20463357, PMID:24037888, PMID:35044439, PMID:32197234, PMID:17350963). In osteoblast differentiation it activates Runx2, alkaline phosphatase, osteocalcin, and bone sialoprotein through chromatin hyperacetylation and H3K4 trimethylation, with Pbx1 switching the locus between HDAC-mediated repression and CBP/p300-mediated activation (PMID:17325044, PMID:20439491). In cancers, HOXA10 promotes EMT, proliferation, and chemoresistance by activating TGFB2/Smad/METTL3 m6A signaling, BCL2, HDAC1 (suppressing KLF4 via DNMT1 methylation), and an ALKBH5/JAK2-m6A/STAT3 cisplatin-resistance loop (PMID:33563300, PMID:31364281, PMID:33596966, PMID:34496932). HOXA10 is itself controlled by upstream repression via EZH2/PRC2 and CTCF-dependent histone modification and by miR-135a/b targeting its 3' UTR (PMID:20565746, PMID:26478432, PMID:21956427).

Mechanistic history

Synthesis pass · year-by-year structured walk · 29 steps
  1. 1995 High

    Established that HOXA10 is required in vivo for axial patterning and reproductive function, defining the biological problem space the protein operates in.

    Evidence Targeted Hoxa10 knockout in mice with phenotypic analysis

    PMID:7700356

    Open questions at the time
    • Does not identify direct transcriptional targets
    • Tissue-autonomous versus systemic contributions not separated
  2. 2000 High

    Demonstrated that maternal uterine HOXA10 is functionally required for embryo implantation, converting the knockout phenotype into a manipulable dose-dependent process.

    Evidence In vivo uterine antisense and expression-plasmid transfection with implantation site counting in mice

    PMID:10981664

    Open questions at the time
    • Downstream implantation effectors not defined
    • Direct DNA targets not identified
  3. 2002 High

    Defined the first post-translational control of HOXA10, showing tyrosine phosphorylation of the homeodomain governs DNA binding and that SHP1 dephosphorylation enables repression of myeloid oxidase genes.

    Evidence Co-IP, phosphotyrosine mapping, EMSA, and reporter assays in myeloid cells

    PMID:12145285

    Open questions at the time
    • Kinase responsible for phosphorylation not identified here
    • In vivo relevance to myelopoiesis not yet established
  4. 2003 High

    Identified the mechanism of HOXA10 repression at oxidase genes as recruitment of HDAC2 via a discrete Pbx1-independent repression domain, mechanistically distinguishing repression from cofactor-dependent activity.

    Evidence Domain mutagenesis, HDAC2 Co-IP, and HDAC inhibitor reporter assays in myeloid cells

    PMID:14512427

    Open questions at the time
    • Other corepressors at these loci not mapped
    • Structural basis of the repression domain unknown
  5. 2005 High

    Generalized the phosphorylation-dependent repression model by showing IFN-γ signaling relieves HOXA10 repression of NCF2, linking cytokine signaling to oxidase gene derepression during differentiation.

    Evidence NCF2 promoter reporters, EMSA, IFN-γ treatment, and HDAC inhibitor experiments

    PMID:16210632

    Open questions at the time
    • Identity of IFN-γ-activated tyrosine kinase not defined
    • Quantitative contribution to differentiation timing unclear
  6. 2006 High

    Completed the phosphatase regulatory axis and connected it to disease by showing SHP2 sustains HOXA10 dephosphorylation, with leukemia-associated activating SHP2 mutants persistently repressing differentiation genes.

    Evidence Co-IP, phosphorylation analysis, reporter assays, and constitutively active SHP2 mutants in myeloid cells

    PMID:17138561

    Open questions at the time
    • Direct causation in human AML not tested here
    • Full target set sustained by SHP2 not enumerated
  7. 2006 Medium

    Showed HOXA10 expression is hormonally and environmentally regulated through estrogen-response and autoregulatory promoter elements, identifying HOXA10 as a node for endocrine disruptor imprinting.

    Evidence ERE/ARE reporter assays, ER antagonist treatment, and in utero BPA exposure in mice

    PMID:17093138

    Open questions at the time
    • Single-lab reporter and imprinting data
    • Mechanism of persistent estrogen-uncoupled expression not defined
  8. 2007 High

    Established HOXA10 as a direct activator of the osteoblast differentiation program acting upstream of and parallel to Runx2 through chromatin modification.

    Evidence ChIP, promoter reporters, siRNA, Runx2-null rescue, and histone modification analysis

    PMID:17325044

    Open questions at the time
    • Histone-modifying enzymes recruited not yet identified
    • Endogenous requirement in bone in vivo not tested
  9. 2007 Medium

    Extended HOXA10 transcriptional control into endometrial decidualization by showing it negatively regulates IGFBP1.

    Evidence Reciprocal HOXA10 overexpression/knockdown with RT-PCR in human endometrial stromal cells

    PMID:17350963

    Open questions at the time
    • Direct promoter binding to IGFBP1 not shown
    • Cofactor dependence not defined
  10. 2008 Medium

    Linked the phosphatase/HOXA10 axis to leukemogenesis and added DUSP4 as an anti-apoptotic activated target sustaining myeloid progenitor survival.

    Evidence Murine bone marrow transplantation with HoxA10 and active SHP2, ChIP, and reporter assays

    PMID:19022774

    Open questions at the time
    • Single-lab in vivo model
    • Relative contribution of DUSP4 versus oxidase repression to AML not dissected
  11. 2008 Medium

    Identified Calpain5 as a HOXA10-regulated gene implicating HOXA10 in endometrial apoptosis resistance.

    Evidence HOXA10 overexpression/siRNA with qRT-PCR and IHC in endometrial cells

    PMID:18829447

    Open questions at the time
    • Single readout method
    • Direct binding to Calpain5 promoter not demonstrated
  12. 2010 High

    Resolved the molecular switch by which Pbx1 converts HOXA10 from repressor to activator at bone gene promoters via differential corepressor/coactivator recruitment.

    Evidence ChIP, Pbx1 shRNA, promoter mutagenesis, and histone modification analysis

    PMID:20439491

    Open questions at the time
    • Signal triggering Pbx1 dissociation not identified
    • Generality of switch to non-bone loci untested
  13. 2010 High

    Demonstrated direct, cell-type-specific repression of KLF9 by HOXA10 binding the KLF9 promoter, refining endometrial epithelial versus stromal target logic.

    Evidence Reporter assays, EMSA, and promoter-site mutation in endometrial cells

    PMID:20463357

    Open questions at the time
    • Basis of epithelial-specific activity not defined
    • In vivo consequence of KLF9 derepression not tested
  14. 2010 High

    Established HOXA10 as a dose-dependent regulator of hematopoietic stem cell self-renewal with defined downstream targets.

    Evidence Doxycycline-inducible transgenic mice, repopulation assays, expression profiling, and binding-site analysis (HLF, Dkk-1, Gata-1)

    PMID:17234739

    Open questions at the time
    • Mechanism of dose-dependent lineage block unclear
    • Direct versus indirect targets incompletely separated
  15. 2010 Medium

    Placed HOXA10 within Polycomb-controlled gene regulation, showing EZH2/PRC2 represses HOXA10 and that HOXA10 activates ID2 in lymphoid cells.

    Evidence EZH2 siRNA, DZNep inhibition, ChIP, and reporter assays in T-cell lines

    PMID:20565746

    Open questions at the time
    • Single-lineage context
    • Functional consequence of EZH2-mediated HOXA10 repression not assayed
  16. 2011 High

    Defined a HOXA10-driven myeloid transcriptional network (ARIH2/Triad1, CDX4, FGF2) creating feedback loops and downstream ubiquitination and proliferation signals.

    Evidence ChIP, promoter reporters, knockdown rescue, ubiquitination, and cytokine proliferation assays in myeloid cells

    PMID:21454682 PMID:21471217 PMID:22493287

    Open questions at the time
    • Network interconnection in primary human progenitors incompletely mapped
    • Hierarchy of these targets not fully ordered
  17. 2012 High

    Closed an autocrine amplification loop showing HOXA10-induced FGF2 activates β-catenin, which feeds back to activate HOXA10 and CDX4.

    Evidence ChIP for β-catenin at HOXA10/CDX4 promoters, FGF2 neutralization, and β-catenin knockdown

    PMID:23038246

    Open questions at the time
    • Loop dynamics over differentiation time not quantified
    • In vivo relevance to leukemia not directly tested
  18. 2012 Medium

    Added FKBP4/FKBP52 as a HOXA10-regulated decidualization gene.

    Evidence Reciprocal overexpression/knockdown with qRT-PCR and Western blot in human endometrial stromal cells

    PMID:22279148

    Open questions at the time
    • Direct binding not shown
    • Single-lab data
  19. 2013 High

    Identified acetylation as a second post-translational control by showing PCAF acetylates HOXA10 at K338/K339 to impair ITGB3 activation and embryo adhesion.

    Evidence Co-IP, site-specific acetylation mapping, ChIP, reporter, and BeWo spheroid attachment assays

    PMID:24037888

    Open questions at the time
    • Deacetylase reversing this mark not identified
    • Crosstalk with phosphorylation control not tested
  20. 2014 Medium

    Showed HOXA10 promotes carcinoma invasion through direct ZIC2 activation and through TGFβ2/p38 MAPK/MMP-3 signaling, expanding its pro-invasive transcriptional outputs.

    Evidence ChIP, truncated promoter reporters, knockdown/overexpression, TGFβ2 neutralization, and p38 inhibition in carcinoma cells

    PMID:24464212 PMID:28338202

    Open questions at the time
    • Context dependence across tumor types not reconciled
    • Single-lab per pathway
  21. 2015 High

    Established HOXA10 as the terminator of emergency granulopoiesis through ARIH2/Triad1 activation, with HoxA9 antagonism set by differential tyrosine phosphorylation.

    Evidence HOXA10 and ARIH2 knockout mice, Triad1 re-expression rescue, reporter assays, and phosphorylation analysis

    PMID:25895533

    Open questions at the time
    • Signals setting stage-specific phosphorylation states not defined
    • Human relevance not directly tested
  22. 2017 High

    Showed that programmed downregulation of HOXA10 in decidua is itself functional, enabling LIF/IL-6/STAT3-driven trophoblast invasion.

    Evidence HOXA10 siRNA in decidual cells, conditioned-medium invasion, STAT3 knockdown rescue, and cytokine ELISA

    PMID:28520923

    Open questions at the time
    • Direct HOXA10 targets controlling LIF/IL-6 not identified
    • Temporal regulation of HOXA10 downregulation not mapped
  23. 2019 Medium

    Connected HOXA10 to apoptosis and epigenetic control in cancer through direct activation of BCL2 and of HDAC1, the latter increasing p53 acetylation when lost.

    Evidence ChIP, luciferase, p53 acetylation analysis, rescue experiments, and xenografts in gastric and hepatocellular carcinoma cells

    PMID:31364281 PMID:31440094

    Open questions at the time
    • BCL2 finding from single lab
    • Tumor-type generality of HDAC1 axis not established
  24. 2020 High

    Identified MEIS1 as a physical HOXA10 cofactor in endometrium directing transcription of KAT2B and ETA required for decidualization.

    Evidence Co-IP, ChIP, reporter assays, CRISPR MEIS1 knockout, and functional rescue in endometrial stromal cells

    PMID:32197234

    Open questions at the time
    • Genome-wide MEIS1-HOXA10 target set not defined
    • Stoichiometry of the complex unknown
  25. 2020 Medium

    Showed HOXA10 inhibits osteogenic differentiation of periodontal ligament stem cells via DKK1-mediated Wnt/β-catenin suppression, revealing context-dependent skeletal regulation opposite to its osteoblast role.

    Evidence Overexpression/knockdown, ALP/Alizarin staining, and LiCl/ICG-001 pharmacological rescue in hPDLSCs

    PMID:32299243

    Open questions at the time
    • Reconciliation with HOXA10's osteoblast-activating role unresolved
    • Direct DKK1 binding not shown
  26. 2021 High

    Established HOXA10 as a positional-memory gene required for genomic stability and mitotic fidelity in somite-derived muscle stem cells.

    Evidence Satellite cell-specific conditional Hoxa10 knockout, regeneration assays, DNA methylation, and mitotic marker immunofluorescence

    PMID:34108202

    Open questions at the time
    • Molecular targets mediating genomic stability not identified
    • Transcription-independent functions not excluded
  27. 2021 High

    Linked HOXA10 to m6A epitranscriptomic signaling in cancer through an ALKBH5/JAK2-m6A/STAT3 loop driving cisplatin resistance and a TGFB2/Smad/METTL3 axis driving EMT.

    Evidence MeRIP-seq, ChIP, RIP, CoIP, m6A assays, and in vivo rescue in ovarian and gastric cancer cells

    PMID:33563300 PMID:34496932

    Open questions at the time
    • Direct versus indirect m6A regulation incompletely separated
    • Applicability across other cancers not tested
  28. 2021 High

    Defined a HOXA10/HDAC1/DNMT1/KLF4 axis in which HOXA10 promotes HDAC1 to stabilize DNMT1 and silence KLF4, driving lung adenocarcinoma progression.

    Evidence ChIP, CoIP, luciferase, methylation analysis, and xenograft rescue in lung adenocarcinoma cells

    PMID:33596966

    Open questions at the time
    • Single tumor model
    • Endogenous requirement in patient tumors not directly tested
  29. 2022 High

    Demonstrated direct HOXA10 activation of E-cadherin via a defined promoter motif to enhance endometrial receptivity, and identified upstream NEAT1/CTCF repression of HOXA10.

    Evidence ChIP, promoter motif mutagenesis, reporter, spheroid attachment, in vivo mouse siRNA, RIP, and histone modification analysis

    PMID:35044439 PMID:35574918

    Open questions at the time
    • Integration of NEAT1/CTCF with hormonal regulation unresolved
    • Quantitative balance of HOXA10 activation versus repression at implantation not modeled

Open questions

Synthesis pass · forward-looking unresolved questions
  • How HOXA10's post-translational code (phosphorylation, acetylation) and cofactor context (Pbx1, MEIS1) are integrated to specify tissue-specific activator versus repressor programs across hematopoiesis, endometrium, bone, and cancer remains unresolved.
  • No genome-wide occupancy map integrated across tissues
  • No structural model of cofactor-modulated DNA binding
  • Rules governing context-dependent activation versus repression undefined

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140110 transcription regulator activity 12 GO:0003677 DNA binding 6 GO:0140097 catalytic activity, acting on DNA 1
Localization
GO:0005634 nucleus 2
Pathway
R-HSA-74160 Gene expression (Transcription) 10 R-HSA-1474165 Reproduction 7 R-HSA-1643685 Disease 6 R-HSA-168256 Immune System 5 R-HSA-4839726 Chromatin organization 5 R-HSA-1266738 Developmental Biology 4
Partners
ALKBH5CDX4HDAC2MEIS1PBX1PCAFSHP1SHP2

Evidence

Reading pass · 39 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1995 Targeted knockout of Hoxa10 in mice causes anterior homeotic transformation of lumbar vertebrae, bilateral cryptorchidism with spermatogenesis defects in males, and uterine-factor embryonic lethality in ~80% of females between days 2.5-3.5 post coitum, coinciding with maternal Hoxa10 expression in distal oviductal and uterine epithelium, establishing a direct role for Hoxa10 in male and female fertility. Targeted gene knockout in mice, phenotypic analysis Nature High 7700356
2000 Maternal Hoxa10 expression in the uterus is required for embryo implantation; antisense oligonucleotide suppression of Hoxa10 before implantation significantly decreased implantation sites, while constitutive Hoxa10 expression increased litter size. In vivo uterine liposome-mediated gene transfection with antisense oligonucleotides or expression plasmid in pregnant mice; implantation site counting Gene therapy High 10981664
2002 HOXA10 protein interacts with and is repressed by SHP1 protein-tyrosine phosphatase in undifferentiated myeloid cells; SHP1 dephosphorylates tyrosine residues in the conserved HOXA10 homeodomain, increasing HoxA10 DNA binding affinity and transcriptional repression of target genes CYBB (gp91PHOX) and NCF2 (p67PHOX). Co-immunoprecipitation of SHP1 with HoxA10; phosphotyrosine analysis; transcriptional reporter assays; EMSA; tyrosine phosphorylation mapping The Journal of biological chemistry High 12145285
2003 HoxA10 represses transcription of CYBB (gp91PHOX) and NCF2 (p67PHOX) in undifferentiated myeloid cells through a Pbx1-independent repression domain (amino acids 224–249) that recruits histone deacetylase 2 (HDAC2); HDAC inhibitors abrogate this repression. Domain deletion/mutagenesis; co-immunoprecipitation of HOXA10 with HDAC2; HDAC inhibitor treatment; transcriptional reporter assays The Journal of biological chemistry High 14512427
2005 HoxA10 represses NCF2 (p67PHOX) transcription via a homologous cis-element in the NCF2 promoter in a tyrosine phosphorylation- and histone deacetylase-dependent manner, paralleling its repression of CYBB; IFN-γ-induced tyrosine phosphorylation of the HoxA10 homeodomain decreases binding to this element and abrogates repression. Reporter assays with NCF2 promoter constructs; EMSA; IFN-γ treatment; HDAC inhibitor experiments; tyrosine phosphorylation analysis Journal of immunology High 16210632
2006 SHP2 protein-tyrosine phosphatase dephosphorylates HoxA10 in undifferentiated myeloid cells, maintaining HoxA10 in a DNA-binding-competent state that represses CYBB and NCF2 transcription; constitutively active SHP2 mutants (found in human AML) sustain HoxA10 dephosphorylation throughout myelopoiesis, persistently repressing myeloid differentiation genes. Co-immunoprecipitation of SHP2 with HoxA10; phosphotyrosine Western blot; transcriptional reporter assays; expression of constitutively active SHP2 mutants The Journal of biological chemistry High 17138561
2006 Bisphenol A (BPA) drives HOXA10 expression through the HOXA10 estrogen response element (ERE) and indirectly through an autoregulatory element (ARE); BPA-induced HOXA10 upregulation via ERE is blocked by ER antagonist ICI, while ARE induction requires ER signaling and HOXA10 itself; in utero BPA exposure imprints lasting stromal HOXA10 overexpression uncoupled from estrogen stimulation in adult mice. Luciferase reporter assays with HOXA10-ERE and ARE constructs; ER antagonist ICI treatment; in vivo in utero BPA exposure; RT-PCR in 2- and 6-week-old offspring FASEB journal Medium 17093138
2007 HOXA10 activates the Runx2 P1 promoter via a functional Hox core motif to induce osteoblast differentiation; HOXA10 also directly activates alkaline phosphatase, osteocalcin, and bone sialoprotein gene promoters; HOXA10 mediates chromatin hyperacetylation and H3K4 trimethylation at these loci; HOXA10 can induce osteoblast genes in Runx2-null cells, establishing a direct Runx2-independent pathway. ChIP; promoter reporter assays; siRNA knockdown; exogenous expression; analysis in Runx2-null cells; histone modification analysis Molecular and cellular biology High 17325044
2007 HOXA10 negatively regulates IGFBP1 mRNA expression in decidualizing human endometrial stromal cells (HSC); overexpression of HOXA10 in HSC decreased IGFBP1 mRNA, while HOXA10 silencing increased IGFBP1 mRNA even in the presence of decidualization stimuli. HOXA10 overexpression and siRNA knockdown in human endometrial stromal cells; RT-PCR for IGFBP1 Molecular human reproduction Medium 17350963
2004 HOXA10 expression in ER-negative BT20 breast cancer cells increases p53 protein expression and reduces invasiveness through Matrigel; estradiol and tamoxifen increase HOXA10 mRNA in ER-positive MCF-7 cells. Constitutive HOXA10 expression in BT20 cells; Matrigel invasion assay; Western blot for p53; RT-PCR/Northern blot for HOXA10 Cancer biology & therapy Medium 15044858
2006 HOXA10 inhibits invasive behavior of endometrial carcinoma cells and tumor dissemination by inducing E-cadherin expression through downregulation of the E-cadherin repressor Snail, thereby suppressing epithelial-mesenchymal transition. Enforced HOXA10 expression in endometrial carcinoma cells; Matrigel invasion assay; nude mouse xenograft; Western blot/RT-PCR for Snail and E-cadherin Cancer research Medium 16424022
2008 Constitutively active SHP2 cooperates with HoxA10 overexpression to accelerate AML progression in mice; HoxA10 activates transcription of DUSP4 (encoding anti-apoptotic Mkp2) in myeloid progenitors, and SHP2-mediated dephosphorylation of HoxA10 maintains DUSP4 activation and CYBB/NCF2 repression throughout myelopoiesis. Murine bone marrow transplantation with HoxA10 overexpression and constitutively active SHP2; reporter assays; ChIP; phosphorylation analysis The Journal of biological chemistry Medium 19022774
2010 Pbx1 negatively regulates Hoxa10-mediated transcription at osteoblast gene promoters (osteocalcin, bone sialoprotein) by associating with histone deacetylases and maintaining H3K9 methylation; during differentiation, Pbx1 dissociates from these promoters allowing Hoxa10 to recruit CBP/p300, increase histone acetylation, and decrease H3K9 methylation to activate transcription. ChIP; shRNA knockdown of Pbx1; wild-type and mutated promoter reporter assays; histone modification analysis Molecular and cellular biology High 20439491
2010 HOXA10 directly represses KLF9 expression specifically in endometrial epithelial cells (not stromal cells) by binding to the KLF9 promoter; EMSA confirmed direct HOXA10–KLF9 promoter binding; targeted mutation of the HOXA10-binding site abolished repression. Transient transfection of HOXA10; reporter assays with KLF9 promoter; EMSA; targeted promoter mutation; immunohistochemistry Biology of reproduction High 20463357
2011 miR-135a and miR-135b directly suppress HOXA10 expression by binding the HOXA10 3' UTR in endometrial stromal cells (cell-type specific; absent in MCF-7 cells); transfection with miR-135a/b or their inhibitors reciprocally altered HOXA10 mRNA and protein; luciferase reporter confirmed binding site. miRNA transfection; luciferase reporter with HOXA10 3' UTR; qPCR; Western blot; endometrial biopsy qPCR The Journal of clinical endocrinology and metabolism Medium 21956427
2011 HoxA10 activates transcription of ARIH2 (encoding the E3 ubiquitin ligase Triad1) via two distinct HoxA10-binding cis elements in the ARIH2 promoter in myeloid cells; HoxA10-overexpressing myeloid cells show a Triad1-dependent increase in protein ubiquitination. Reporter assays with ARIH2 promoter cis elements; ChIP; Western blot for ubiquitination; Triad1 knockdown rescue experiments The Journal of biological chemistry High 21454682
2011 HoxA10 activates CDX4 transcription via a cis element in the CDX4 promoter; Cdx4 in turn activates the HOXA10 promoter via a Cdx4-binding cis element, forming a positive feedback loop; CDX4 knockdown decreases cytokine hypersensitivity in HoxA10-overexpressing myeloid progenitors. Reporter assays with CDX4 and HOXA10 promoter cis elements; ChIP; knockdown experiments; cytokine proliferation assays The Journal of biological chemistry High 21471217
2012 HoxA10 activates Fgf2 transcription via two cis elements in the FGF2 proximal promoter in myeloid cells, increasing Fgf2 secretion; autocrine Fgf2 activates a PI3K-dependent increase in β-catenin, stimulating myeloid progenitor proliferation and cytokine hypersensitivity. Reporter assays with FGF2 promoter cis elements; ChIP; Fgf2 secretion ELISA; PI3K inhibitor treatment; β-catenin Western blot; proliferation assays The Journal of biological chemistry High 22493287
2012 β-Catenin directly activates HOXA10 and CDX4 transcription via novel cis elements in their promoters in myeloid progenitor cells; HoxA10-induced Fgf2 production activates β-catenin in an autocrine manner, which then further amplifies HOXA10 and CDX4 expression. Reporter assays; ChIP for β-catenin at HOXA10 and CDX4 promoters; Fgf2 neutralization; β-catenin knockdown The Journal of biological chemistry High 23038246
2013 PCAF acetyltransferase physically interacts with HOXA10 and acetylates it at lysines K338 and K339, impairing HOXA10-mediated transcription of ITGB3 (β3-integrin) and reducing embryo adhesiveness in endometrial epithelial cells. Co-immunoprecipitation; confocal immunofluorescence; luciferase reporter; ChIP; Western blot; BeWo spheroid attachment assay; siRNA knockdown/overexpression of PCAF The Journal of clinical endocrinology and metabolism High 24037888
2012 HOXA10 regulates FKBP4 (FKBP52) expression in human endometrial stromal cells; overexpression of HOXA10 increased FKBP4 mRNA and protein, while HOXA10 knockdown decreased FKBP4 expression and impaired decidualization. HOXA10 overexpression and siRNA knockdown in HESCs; qRT-PCR; Western blot; decidualization markers (IGFBP1) Reproduction Medium 22279148
2008 HOXA10 directly regulates Calpain5 expression in endometrial cells; transfection with HOXA10 expression construct increased Calpain5 mRNA, while HOXA10 siRNA decreased Calpain5 expression, suggesting HOXA10 promotes apoptosis resistance via a Calpain5/caspase pathway. HOXA10 overexpression and siRNA in HESC cells; qRT-PCR; immunohistochemistry Molecular human reproduction Medium 18829447
2010 HOXA10 controls hematopoietic stem cell self-renewal and repopulating capacity in a dose-dependent manner; intermediate HOXA10 levels expand HSCs ~15-fold after in vitro culture, while high levels block erythroid and megakaryocyte development; downstream targets include HLF, Dkk-1, Gfi-1, and Gata-1, with HOXA10 binding sites confirmed in HLF, Dkk-1, and Gata-1, and transcriptional activation of Dkk-1 and Gfi-1 demonstrated. Doxycycline-inducible transgenic mice; bone marrow repopulation assays; gene expression profiling; HOXA10 binding site analysis Blood High 17234739
2015 HoxA10 terminates emergency granulopoiesis by activating ARIH2 (Triad1) transcription during myeloid differentiation; HOXA10-knockout mice exhibit overwhelming fatal emergency granulopoiesis reversed by re-expression of Triad1 in bone marrow; HoxA9 antagonizes this by repressing ARIH2 transcription; differentiation-stage-specific ARIH2 transcription is regulated by tyrosine phosphorylation states of HoxA9 and HoxA10. HOXA10 knockout mice; bone marrow Triad1 re-expression rescue; ARIH2 knockout mice; reporter assays; phosphorylation analysis Journal of immunology High 25895533
2017 Downregulation of HOXA10 in decidual cells after embryo implantation promotes trophoblast invasion by increasing LIF and IL-6 secretion, which activates STAT3 (Tyr705) in trophoblast cells, upregulating MMP activity and decreasing TIMPs; STAT3 knockdown in trophoblasts rescues the invasion mediated by HOXA10-depleted decidual cells. HOXA10 siRNA depletion of decidual cells; conditioned medium trophoblast invasion assay; MMP activity assay; STAT3 knockdown; Western blot for phospho-STAT3; ELISA for LIF and IL-6 Endocrinology High 28520923
2020 MEIS1 physically interacts with HOXA10 in human endometrial stromal cells; the MEIS1-HOXA10 complex binds the promoters of KAT2B and ETA and regulates their transcriptional activity; MEIS1 deficiency (siRNA and CRISPR-Cas9) impairs decidualization, and KAT2B/ETA overexpression partially rescues decidualization defects in MEIS1-knockout cells. Co-immunoprecipitation of MEIS1 with HOXA10; siRNA and CRISPR-Cas9 MEIS1 knockout; luciferase reporter; ChIP for MEIS1-HOXA10 at KAT2B and ETA promoters; rescue overexpression Journal of molecular endocrinology High 32197234
2021 Hoxa10 is required for genomic stability and mitotic function in somite-derived satellite cells; satellite cell-specific Hoxa10 ablation in mice causes genomic instability, mitotic catastrophe, and impaired regeneration specifically of somite-derived muscles (not cranial mesoderm-derived muscles), establishing Hoxa10 as a positional memory gene in adult muscle stem cells. Satellite cell-specific conditional Hoxa10 knockout mice; muscle regeneration assays; DNA methylation analysis of Hox-A locus; immunofluorescence for mitotic markers Science advances High 34108202
2021 HOXA10 acts as an upstream transcription factor for ALKBH5 and forms a regulatory loop with it; the ALKBH5-HOXA10 loop activates the JAK2/STAT3 signaling pathway by mediating ALKBH5-dependent m6A demethylation of JAK2 mRNA, promoting cisplatin resistance in epithelial ovarian cancer cells. MeRIP-seq; RNA-seq; ChIP; RNA immunoprecipitation; luciferase reporter; in vitro and in vivo functional assays; ALKBH5/HOXA10 knockdown Journal of experimental & clinical cancer research High 34496932
2021 HOXA10 promotes gastric cancer EMT and metastasis by binding the TGFB2 promoter, activating TGFB2 transcription and secretion, triggering TGFβ/Smad signaling with Smad2/3 nuclear translocation; the downstream Smad proteins mediate METTL3 expression (confirmed by CoIP and ChIP), and METTL3 elevates overall m6A levels to drive EMT. ChIP-qPCR for HOXA10 at TGFB2 promoter; dual-luciferase reporter; CoIP of Smad proteins with METTL3; colorimetric m6A assay; in vivo lung metastasis models; rescue experiments Journal of experimental & clinical cancer research High 33563300
2019 HOXA10 binds the BCL2 promoter region and induces BCL2 expression, thereby inhibiting the intrinsic apoptosis pathway and promoting gastric cancer cell proliferation. ChIP-qPCR for HOXA10 at BCL2 promoter; qRT-PCR; Western blot; rescue experiments; in vivo xenograft Cancer medicine Medium 31364281
2019 HOXA10 knockdown in hepatocellular carcinoma cells suppresses HDAC1 transcription (via direct HOXA10 binding to HDAC1 promoter confirmed by ChIP and luciferase assay), leading to increased p53 acetylation at Lys382, cell cycle arrest, and apoptosis; HDAC1 overexpression reverses the effects of HOXA10 knockdown. siRNA knockdown; ChIP and luciferase reporter for HOXA10 at HDAC1 promoter; flow cytometry; Western blot for p53 acetylation; in vivo xenograft; rescue experiments Cancer management and research High 31440094
2021 HOXA10 promotes HDAC1 expression in lung adenocarcinoma; HDAC1 deacetylates DNMT1 to stabilize it, and DNMT1 methylates the KLF4 promoter to silence KLF4, creating a HOXA10/HDAC1/DNMT1/KLF4 axis that drives LAD proliferation and migration; CoIP confirmed HDAC1-DNMT1 interaction. ChIP; dual luciferase assay; CoIP of HDAC1 with DNMT1; siRNA/shRNA depletion; Western blot; in vivo xenograft Journal of experimental & clinical cancer research High 33596966
2022 HOXA10 directly binds a conserved motif (TGTACTAAAAA) in the E-cadherin promoter to activate E-cadherin expression, improving endometrial receptivity and embryo adhesion; siRNA knockdown of HOXA10 in mice reduced implantation and live birth rates. ChIP for HOXA10 at E-cadherin promoter; dual luciferase reporter; siRNA and overexpression transfection; JEG-3 spheroid attachment assay; in vivo HOXA10 siRNA mouse model Biology of reproduction High 35044439
2014 HOXA10 directly binds the ZIC2 promoter and upregulates ZIC2 transcription in nasopharyngeal carcinoma cells; luciferase reporters with truncated ZIC2 promoter sequences confirmed the HOXA10 binding site; ZIC2 knockdown reverses HOXA10-induced proliferation and invasion. ChIP; luciferase reporters with truncated ZIC2 promoter; HOXA10 overexpression; ZIC2 siRNA rescue European review for medical and pharmacological sciences Medium 28338202
2014 HOXA10 promotes pancreatic cancer cell invasion and MMP-3 expression via TGFβ2-mediated activation of the p38 MAPK pathway; HOXA10 knockdown decreases TGFβ2 and MMP-3 expression and suppresses p38 activation; TGFβ2 neutralization or p38 inhibition blocks HOXA10-mediated invasion. siRNA knockdown; overexpression; TGFβ2 neutralizing antibody; p38 inhibitor (SB239063); invasion assays; Western blot Digestive diseases and sciences Medium 24464212
2015 CTCF binds a 20 bp motif in the HOXA10 core promoter region and negatively regulates HOXA10 expression in breast cancer cells by maintaining H3K27me3 inactivation marks at the HOXA10 promoter; in silico and in vitro mutation assays confirmed the CTCF binding site. ChIP for CTCF and H3K27me3 at HOXA10 promoter; promoter reporter assay; in silico binding site prediction; mutation assay; CTCF overexpression and knockdown Biochemical and biophysical research communications Medium 26478432
2020 HOXA10 inhibits osteogenic differentiation of periodontal ligament stem cells by increasing DKK1 expression and reducing nuclear β-catenin accumulation; HOXA10 overexpression reduces nuclear β-catenin and increases DKK1; effects are rescued by Wnt/β-catenin activator LiCl, and HOXA10 knockdown effects are antagonized by Wnt inhibitor ICG-001. HOXA10 overexpression and knockdown in hPDLSCs; ALP and Alizarin Red staining; Western blot for nuclear β-catenin and DKK1; LiCl and ICG-001 treatment Connective tissue research Medium 32299243
2022 LncRNA NEAT1 binds CTCF and recruits it to the HOXA10 promoter; CTCF binding downregulates HOXA10 gene expression by regulating histone modification levels; the lncRNA NEAT1/CTCF/HOXA10 signaling pathway regulates endometrial epithelial cell proliferation and endometrial receptivity establishment. RNA immunoprecipitation; ChIP; histone modification analysis; in vitro and in vivo knockdown models; trophoblast attachment assay Cell cycle Medium 35574918
2010 EZH2 (component of Polycomb Repressor Complex 2, PRC2) represses HOXA10 expression in T-cell lines; siRNA knockdown of EZH2 in JURKAT cells enhanced HOXA10 expression, and DZNep (EZH2/PRC2 inhibitor) treatment elevated HOXA10 expression; HOXA10 and HOXA9 directly activated ID2 expression (ChIP and promoter analysis). siRNA knockdown of EZH2; DZNep pharmacological inhibition; ChIP; promoter reporter; overexpression Molecular cancer Medium 20565746

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1995 Sexually dimorphic sterility phenotypes in Hoxa10-deficient mice. Nature 436 7700356
2007 Altered expression of HOXA10 in endometriosis: potential role in decidualization. Molecular human reproduction 182 17350963
2000 Alteration of maternal Hoxa10 expression by in vivo gene transfection affects implantation. Gene therapy 173 10981664
2010 The role of the Hoxa10/HOXA10 gene in the etiology of endometriosis and its related infertility: a review. Journal of assisted reproduction and genetics 152 20821045
2007 HOXA10 controls osteoblastogenesis by directly activating bone regulatory and phenotypic genes. Molecular and cellular biology 143 17325044
2021 ALKBH5-HOXA10 loop-mediated JAK2 m6A demethylation and cisplatin resistance in epithelial ovarian cancer. Journal of experimental & clinical cancer research : CR 124 34496932
1999 Regulation of HOXA-10 and its expression in normal and abnormal endometrium. Molecular human reproduction 112 10460226
2021 HOXA10 mediates epithelial-mesenchymal transition to promote gastric cancer metastasis partly via modulation of TGFB2/Smad/METTL3 signaling axis. Journal of experimental & clinical cancer research : CR 110 33563300
2011 MicroRNA 135 regulates HOXA10 expression in endometriosis. The Journal of clinical endocrinology and metabolism 110 21956427
2006 Deregulation of the HOXA10 homeobox gene in endometrial carcinoma: role in epithelial-mesenchymal transition. Cancer research 109 16424022
2004 HOXA10 regulates p53 expression and matrigel invasion in human breast cancer cells. Cancer biology & therapy 100 15044858
2012 miRNA-135a promotes breast cancer cell migration and invasion by targeting HOXA10. BMC cancer 98 22439757
1995 Stage- and lineage-specific expression of the HOXA10 homeobox gene in normal and leukemic hematopoietic cells. Experimental hematology 94 7556525
2007 HOXA10 is a critical regulator for hematopoietic stem cells and erythroid/megakaryocyte development. Blood 92 17234739
2001 Overexpression of HOXA10 perturbs human lymphomyelopoiesis in vitro and in vivo. Blood 89 11290589
2019 Quercetin inhibits cell viability, migration and invasion by regulating miR-16/HOXA10 axis in oral cancer. European journal of pharmacology 83 30639311
2010 Regional development of uterine decidualization: molecular signaling by Hoxa-10. Molecular reproduction and development 78 19921737
2014 MiR-135a functions as a tumor suppressor in epithelial ovarian cancer and regulates HOXA10 expression. Cellular signalling 67 24607788
2006 Xenoestrogen exposure imprints expression of genes (Hoxa10) required for normal uterine development. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 64 17093138
2010 Pbx1 represses osteoblastogenesis by blocking Hoxa10-mediated recruitment of chromatin remodeling factors. Molecular and cellular biology 61 20439491
2014 miR-494 represses HOXA10 expression and inhibits cell proliferation in oral cancer. Oral oncology 60 25500095
2002 Hydrosalpinx fluid diminishes endometrial cell HOXA10 expression. Fertility and sterility 57 12215336
2013 PCAF impairs endometrial receptivity and embryo implantation by down-regulating β3-integrin expression via HOXA10 acetylation. The Journal of clinical endocrinology and metabolism 56 24037888
2018 Methylation of the HOXA10 Promoter Directs miR-196b-5p-Dependent Cell Proliferation and Invasion of Gastric Cancer Cells. Molecular cancer research : MCR 50 29453320
2002 SHP1 protein-tyrosine phosphatase regulates HoxA10 DNA binding and transcriptional repression activity in undifferentiated myeloid cells. The Journal of biological chemistry 49 12145285
2012 FKBP4 is regulated by HOXA10 during decidualization and in endometriosis. Reproduction (Cambridge, England) 48 22279148
2018 LncRNA H19 regulates the expression of its target gene HOXA10 in endometrial carcinoma through competing with miR-612. European review for medical and pharmacological sciences 46 30070313
2008 Constitutively active SHP2 cooperates with HoxA10 overexpression to induce acute myeloid leukemia. The Journal of biological chemistry 45 19022774
2018 LncHOXA10 drives liver TICs self-renewal and tumorigenesis via HOXA10 transcription activation. Molecular cancer 43 30545354
2017 HOXA10 promotes nasopharyngeal carcinoma cell proliferation and invasion via inducing the expression of ZIC2. European review for medical and pharmacological sciences 42 28338202
2010 Reduced expression of HOXA10 in the midluteal endometrium from infertile women with minimal endometriosis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 42 20971605
2004 Uterine receptivity and implantation: the regulation and action of insulin-like growth factor binding protein-1 (IGFBP-1), HOXA10 and forkhead transcription factor-1 (FOXO-1) in the baboon endometrium. Reproductive biology and endocrinology : RB&E 42 15200677
2021 Obesity regulates miR-467/HoxA10 axis on osteogenic differentiation and fracture healing by BMSC-derived exosome LncRNA H19. Journal of cellular and molecular medicine 40 33471953
2019 Long noncoding RNA LINC00483/microRNA-144 regulates radiosensitivity and epithelial-mesenchymal transition in lung adenocarcinoma by interacting with HOXA10. Journal of cellular physiology 40 30714135
2019 HOXA10 induces BCL2 expression, inhibits apoptosis, and promotes cell proliferation in gastric cancer. Cancer medicine 40 31364281
2021 Hoxa10 mediates positional memory to govern stem cell function in adult skeletal muscle. Science advances 37 34108202
2016 Aberrant HOXA10 Methylation in Patients With Common Gynecologic Disorders: Implications for Reproductive Outcomes. Reproductive sciences (Thousand Oaks, Calif.) 37 26865543
2015 HOXA10 controls proliferation, migration and invasion in oral squamous cell carcinoma. International journal of clinical and experimental pathology 37 26097543
2014 HOXA10 promotes cell invasion and MMP-3 expression via TGFβ2-mediated activation of the p38 MAPK pathway in pancreatic cancer cells. Digestive diseases and sciences 37 24464212
2012 HoxA10 protein regulates transcription of gene encoding fibroblast growth factor 2 (FGF2) in myeloid cells. The Journal of biological chemistry 36 22493287
2006 Activation of SHP2 protein-tyrosine phosphatase increases HoxA10-induced repression of the genes encoding gp91(PHOX) and p67(PHOX). The Journal of biological chemistry 36 17138561
2003 HoxA10 represses gene transcription in undifferentiated myeloid cells by interaction with histone deacetylase 2. The Journal of biological chemistry 36 14512427
2014 DNA methylation of HOXA10 in eutopic and ectopic endometrium. Human reproduction (Oxford, England) 35 24963168
2010 Polycomb repressor complex 2 regulates HOXA9 and HOXA10, activating ID2 in NK/T-cell lines. Molecular cancer 35 20565746
2009 HOXA10 signals on the highway through pregnancy. Journal of reproductive immunology 35 19854516
2022 HOXA10 improves endometrial receptivity by upregulating E-cadherin†. Biology of reproduction 34 35044439
2019 The stem cell-specific long noncoding RNA HOXA10-AS in the pathogenesis of KMT2A-rearranged leukemia. Blood advances 34 31867596
2017 Decrease in Expression of HOXA10 in the Decidua After Embryo Implantation Promotes Trophoblast Invasion. Endocrinology 34 28520923
2022 Metformin Alleviates Endometriosis and Potentiates Endometrial Receptivity via Decreasing VEGF and MMP9 and Increasing Leukemia Inhibitor Factor and HOXA10. Frontiers in pharmacology 32 35273494
2022 The roles and expression of HOXA/Hoxa10 gene: A prospective marker of mammalian female fertility? Reproductive biology 32 35550944
2020 Circular RNA circCSNK1G3 induces HOXA10 signaling and promotes the growth and metastasis of lung adenocarcinoma cells through hsa-miR-143-3p sponging. Cellular oncology (Dordrecht, Netherlands) 32 33118120
2019 MiR-27b-3p promotes migration and invasion in colorectal cancer cells by targeting HOXA10. Bioscience reports 32 31763673
2014 GnRH analogues may increase endometrial Hoxa10 promoter methylation and affect endometrial receptivity. Molecular medicine reports 32 25323439
2010 Identification of aberrant promoter hypomethylation of HOXA10 in ovarian cancer. Journal of cancer research and clinical oncology 32 20151152
2020 CircCTDP1 promotes nasopharyngeal carcinoma progression via a microRNA‑320b/HOXA10/TGFβ2 pathway. International journal of molecular medicine 31 31985027
2019 HOXA10 knockdown inhibits proliferation, induces cell cycle arrest and apoptosis in hepatocellular carcinoma cells through HDAC1. Cancer management and research 31 31440094
2018 HOXA10‑AS: A novel oncogenic long non‑coding RNA in glioma. Oncology reports 31 30132568
2014 miR-218 modulate hepatocellular carcinoma cell proliferation through PTEN/AKT/PI3K pathway and HoxA10. International journal of clinical and experimental pathology 31 25120782
2019 HOXA10 deteriorates gastric cancer through activating JAK1/STAT3 signaling pathway. Cancer management and research 29 31406476
2018 Epigenetic Dynamics of HOXA10 Gene in Infertile Women With Endometriosis. Reproductive sciences (Thousand Oaks, Calif.) 29 29592776
2005 HoxA10 represses transcription of the gene encoding p67phox in phagocytic cells. Journal of immunology (Baltimore, Md. : 1950) 29 16210632
2024 m6A/HOXA10-AS/ITGA6 axis aggravates oxidative resistance and malignant progression of laryngeal squamous cell carcinoma through regulating Notch and Keap1/Nrf2 pathways. Cancer letters 28 38369001
2008 Calpain5 expression is decreased in endometriosis and regulated by HOXA10 in human endometrial cells. Molecular human reproduction 28 18829447
2022 LncRNA NEAT1 affects endometrial receptivity by regulating HOXA10 promoter activity. Cell cycle (Georgetown, Tex.) 27 35574918
2015 CTCF negatively regulates HOXA10 expression in breast cancer cells. Biochemical and biophysical research communications 27 26478432
2012 PTEN loss and HOXA10 expression are associated with ovarian endometrioid adenocarcinoma differentiation and progression. Carcinogenesis 27 23276799
2011 HoxA10 influences protein ubiquitination by activating transcription of ARIH2, the gene encoding Triad1. The Journal of biological chemistry 27 21454682
2007 HOXA10 mutations in congenital absence of uterus and vagina. Fertility and sterility 27 17482600
2017 HOXA7, HOXA9, and HOXA10 are differentially expressed in clival and sacral chordomas. Scientific reports 25 28515451
2014 Upregulation HOXA10 homeobox gene in endometrial cancer: role in cell cycle regulation. Medical oncology (Northwood, London, England) 24 24943991
2011 HoxA10 activates CDX4 transcription and Cdx4 activates HOXA10 transcription in myeloid cells. The Journal of biological chemistry 23 21471217
2003 Endometrial HOXA10 expression after controlled ovarian hyperstimulation with recombinant follicle-stimulating hormone. Fertility and sterility 22 14505762
2025 HOXA10 and HOXA11 in Human Endometrial Benign Disorders: Unraveling Molecular Pathways and Their Impact on Reproduction. Biomolecules 21 40305321
2019 Tumor-Promoting Activity of Long Noncoding RNA LINC00466 in Lung Adenocarcinoma via miR-144-Regulated HOXA10 Axis. The American journal of pathology 21 31381886
2013 HOXA10 mRNA expression and promoter DNA methylation in female pig offspring after in utero estradiol-17β exposure. The Journal of steroid biochemistry and molecular biology 21 24056088
2010 HOXA10 inhibits Kruppel-like factor 9 expression in the human endometrial epithelium. Biology of reproduction 21 20463357
2006 Thrombin and interleukin-1beta regulate HOXA10 expression in human term decidual cells: implications for preterm labor. The Journal of clinical endocrinology and metabolism 21 16551735
2024 Role of HOXA10 in pathologies of the endometrium. Reviews in endocrine & metabolic disorders 20 39499452
2023 Expression of HOXA10 Gene in Women with Endometriosis: A Systematic Review. International journal of molecular sciences 20 37629050
2020 HOXA10 inhibit the osteogenic differentiation of periodontal ligament stem cells by regulating β-catenin localization and DKK1 expression. Connective tissue research 20 32299243
2017 Aberrant Expression of lncRNA ( HOXA11-AS1) and Homeobox A ( HOXA9, HOXA10, HOXA11, and HOXA13) Genes in Infertile Women With Endometriosis. Reproductive sciences (Thousand Oaks, Calif.) 20 29017417
2015 HoxA10 Terminates Emergency Granulopoiesis by Increasing Expression of Triad1. Journal of immunology (Baltimore, Md. : 1950) 20 25895533
2021 Long non-coding RNA PSMA3-AS1 promotes glioma progression through modulating the miR-411-3p/HOXA10 pathway. BMC cancer 19 34294084
2018 Decreased Expression of HOXA10 May Activate the Autophagic Process in Ovarian Endometriosis. Reproductive sciences (Thousand Oaks, Calif.) 19 29658437
2009 The Müllerian HOXA10 gene promotes growth of ovarian surface epithelial cells by stimulating epithelial-stromal interactions. Molecular and cellular endocrinology 19 20036708
2022 Modular scaffolding by lncRNA HOXA10-AS promotes oral cancer progression. Cell death & disease 18 35858923
2021 hsa_circ_001946 elevates HOXA10 expression and promotes the development of endometrial receptivity via sponging miR-135b. Diagnostic pathology 18 33993878
2020 HOXA10 promotes the development of bladder cancer through regulating FOSL1. European review for medical and pharmacological sciences 18 32271412
2020 MiRNA-128 and MiRNA-142 Regulate Tumorigenesis and EMT in Oral Squamous Cell Carcinoma Through HOXA10. Cancer management and research 18 33116855
2011 Expression of HOXA-10 and HOXA-11 in the endometria of women with idiopathic infertility. Folia histochemica et cytobiologica 18 21526497
2004 HOXA10 expression in endometrial adenocarcinoma. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 18 15627890
2021 HOXA10 promotion of HDAC1 underpins the development of lung adenocarcinoma through the DNMT1-KLF4 axis. Journal of experimental & clinical cancer research : CR 17 33596966
2020 Inhibition of Splicing Factor 3b Subunit 1 (SF3B1) Reduced Cell Proliferation, Induced Apoptosis and Resulted in Cell Cycle Arrest by Regulating Homeobox A10 (HOXA10) Splicing in AGS and MKN28 Human Gastric Cancer Cells. Medical science monitor : international medical journal of experimental and clinical research 17 31927557
2019 HOXA10 expression profiling in prostate cancer. The Prostate 17 30614022
2018 DNA Methylation Inhibitor 5-Aza-2'-Deoxycytidine Modulates Endometrial Receptivity Through Upregulating HOXA10 Expression. Reproductive sciences (Thousand Oaks, Calif.) 17 30522400
2017 miR-182 selectively targets HOXA10 in goat endometrial epithelium cells in vitro. Reproduction in domestic animals = Zuchthygiene 17 28758253
2022 HOXA10 Regulates the Synthesis of Cholesterol in Endometrial Stromal Cells. Frontiers in endocrinology 16 35546998
2020 HOXA10 co-factor MEIS1 is required for the decidualization in human endometrial stromal cell. Journal of molecular endocrinology 16 32197234
2017 Increased methylation and decreased expression of homeobox genes TLX1, HOXA10 and DLX5 in human placenta are associated with trophoblast differentiation. Scientific reports 16 28674422
2012 β-Catenin activates the HOXA10 and CDX4 genes in myeloid progenitor cells. The Journal of biological chemistry 16 23038246

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