PBX1
Pre-B-cell leukemia transcription factor 1 · UniProt P40424
- Length
- 430 aa
- Mass
- 46.6 kDa
- Annotated
- 2026-04-29
100 papers in source corpus
46 papers cited in narrative
46 extracted findings
Mechanistic narrative
Synthesis pass · prose summary of the discoveries below
Stage 2 failed
Mechanism profile
Synthesis pass · controlled-vocabulary classification · explore literature graph →
No controlled-vocabulary terms were assigned to this entry.
Evidence
Reading pass · 46 per-paper findings extracted from the source corpus
| Year | Finding | Method | Journal | Conf | PMIDs |
|---|---|---|---|---|---|
| 1999 | Crystal structure of the HoxB1-Pbx1 heterodimer bound to DNA at 2.35 Å resolution revealed that heterodimer contacts are mediated by the HoxB1 hexapeptide binding into a pocket in the Pbx1 protein formed by a three-amino acid insertion in the Pbx1 homeodomain; Pbx1 contains an additional fourth alpha helix beyond the canonical homeodomain that contributes to HoxB1 hexapeptide binding and stable DNA binding. | X-ray crystallography (2.35 Å structure of ternary HoxB1-Pbx1-DNA complex) | Cell | High | 10052460 |
| 1995 | The hexapeptide motif (LFPWMR) of HoxB-8, along with its linker region, is required for cooperative DNA binding of Hox proteins with Pbx1 and Pbx2; position of the hexapeptide relative to the homeodomain is critical for cooperativity. | In vitro DNA-binding assays with deletion and point mutants of HoxB-8 hexapeptide and linker | Proceedings of the National Academy of Sciences of the United States of America | High | 7568094 |
| 1994 | PBX1 was identified as a direct binding protein for the cAMP-regulatory sequence CRS1 of the CYP17 gene; purified Pbx1a and Pbx1b proteins enhance in vitro transcription of a CRS1-driven reporter and overexpression of Pbx1 in adrenocortical Y1 cells enhances cAMP-dependent transcription, establishing a role for Pbx1 in steroidogenesis regulation. | Affinity purification from nuclear extracts, microsequencing, in vitro transcription assay, overexpression in Y1 cells | The Journal of biological chemistry | High | 7913464 |
| 1994 | The PBX1 homeodomain (and those of PBX2 and PBX3) recognizes the consensus sequence ATCAATCA; wild-type PBX proteins are incapable of activating transcription through this motif, whereas the E2A-PBX1 fusion protein activates transcription via the homeodomain in a DNA-binding-dependent manner, demonstrating that fusion with E2A confers transcriptional activation activity absent from wild-type PBX1. | Binding site selection assay, gel-shift with nuclear extracts, reporter gene transfection assays | Oncogene | High | 8183558 |
| 1996 | An internal domain of Pbx1 upstream of the homeodomain represses transcription driven by the Sp1 activation domain (but not VP16 or p53 activation domains), and this repression does not require homeodomain-dependent DNA binding, revealing that Pbx1 can modulate transcription via a DNA-binding-independent mechanism. | Transient transfection reporter assays with Pbx1 deletion constructs | Proceedings of the National Academy of Sciences of the United States of America | Medium | 8552663 |
| 1997 | A conserved motif carboxy-terminal to the Pbx1 homeodomain, termed the Hox Cooperativity Motif (HCM), is necessary and sufficient for cooperative DNA binding with Hox proteins, cellular transcriptional activity, and oncogenic transformation by E2A-Pbx1; deletion or point mutations in the HCM abrogate transformation even though the homeodomain is entirely dispensable for fibroblast transformation. | Deletional and site-directed mutagenesis of E2A-Pbx1, NIH 3T3 focus-formation assays, DNA-binding assays | Molecular and cellular biology | High | 8972188 |
| 1996 | DNA binding by the Pbx1 homeodomain is important for E2A-Pbx1-mediated immortalization of myeloid progenitors (blocking differentiation) but is dispensable for fibroblast focus-formation; the first (N-terminal) transcriptional activation domain of E2A is essential for both transforming activities. | Homeodomain point mutations and large deletions in E2A-Pbx1, myeloid immortalization assays, NIH 3T3 transformation assays | Oncogene | High | 8552391 |
| 1998 | Cellular transformation and proliferation induced by Hoxb4 and Hoxb3 require the presence of Pbx1; the conserved tetrapeptide and homeodomain regions of Hox proteins that mediate PBX binding and DNA binding, respectively, are both required for Hox-induced transformation, establishing that cooperative HOX-PBX interactions underlie Hox-induced cellular transformation. | Co-overexpression of HOX and PBX1 in Rat-1 cells, focus-formation assays, mutant HOX protein analysis | Oncogene | Medium | 9692548 |
| 2001 | Pbx1-deficient mouse embryos display widespread skeletal patterning defects restricted to domains specified by Hox proteins bearing Pbx dimerization motifs, with markedly diminished chondrocyte proliferation and increased hypertrophic chondrocytes accompanied by premature ossification; these defects are not accompanied by changes in Hox gene expression, establishing Pbx1 as a co-regulator that coordinates chondrocyte proliferation and terminal differentiation timing. | Pbx1 knockout mouse analysis (embryonic lethal at E15/16), histology, molecular marker expression | Development (Cambridge, England) | High | 11566859 |
| 2001 | Pbx1 is required for maintenance of definitive hematopoiesis; Pbx1-null fetal livers show reduced hematopoietic stem cell colony-forming activity, failure to reconstitute multilineage hematopoiesis competitively, and a proliferative defect at the level of common myeloid progenitors, establishing Pbx1 as essential for progenitor proliferative amplification during erythropoiesis. | Pbx1 knockout mouse, competitive reconstitution, clonogenic progenitor assays, cell cycle analysis | Blood | High | 11468159 |
| 2002 | Pbx1 is required in vivo for normal pancreatic development; Pbx1-null embryos display pancreatic hypoplasia and defects in exocrine and endocrine differentiation with severely reduced Isl1 and Atoh5 expression; trans-heterozygous Pbx1+/−;Ipf1+/− mice develop age-dependent diabetes, demonstrating in vivo genetic interaction between Pbx1 and Ipf1/Pdx1. | Pbx1 knockout and compound Pbx1/Ipf1 heterozygous mice, glucose tolerance tests, pancreatic histology, molecular marker analysis | Nature genetics | High | 11912494 |
| 2003 | Pbx1 is required for adrenal development; loss of Pbx1 results in complete absence of adrenal glands correlated with decreased proliferation in genital ridges and severely reduced expression of steroidogenic factor-1 (SF-1), placing Pbx1 upstream of SF-1 in adrenocortical development. | Pbx1 knockout mouse, immunohistochemistry, SF-1 expression analysis | Genesis (New York, N.Y. : 2000) | High | 14595835 |
| 2003 | Pbx1 is required in metanephric mesenchyme for normal nephron formation and ureteric branching; heterologous recombination studies confirmed that Pbx1-null renal defects arise exclusively from mesenchymal dysfunction, establishing Pbx1 as an essential regulator of mesenchymal-epithelial signaling during renal morphogenesis. | Pbx1 knockout mouse, tissue explant recombination cultures, molecular marker analysis | Developmental biology | High | 12591246 |
| 2005 | Pbx1 is required for splenic cell specification; Hox11 and Nkx2.5 are absent in Pbx1-null splenic anlage; ChIP assays show Pbx1 binds the Hox11 promoter in spleen mesenchymal cells; Pbx1 and Hox11 genetically interact in spleen formation, establishing a Pbx1-Hox11-dependent transcriptional pathway in splenogenesis. | Pbx1 knockout and compound mutant mice, chromatin immunoprecipitation (ChIP), transcriptional reporter assays, genetic epistasis | Development (Cambridge, England) | High | 15944191 |
| 2006 | A fetal adrenal enhancer (FAdE) containing Pbx-Prep and Pbx-Hox binding sites initiates Ad4BP/SF-1 transcription; a limited number of Hox family members expressed in the adrenal primordia bind these sites as a Hox-Pbx1-Prep1 ternary complex to initiate SF-1 expression before the SF-1 autoregulatory loop is established. | Transgenic mouse enhancer assays, electrophoretic mobility shift assays (EMSA), mutation analysis of binding sites | Molecular and cellular biology | High | 16705164 |
| 2005 | PREP1-PBX1 heterodimers bind PM sites (PM1, PM2, R2/PM3) in the Hoxb1 autoregulatory enhancer and cooperate with Pbx1-Hoxb1 complexes at PH sites to regulate Hoxb1 r4 expression; a new ternary PREP1-PBX1-HOXB1 complex is formed at the combined R3/PM2 sites and is sufficient for hindbrain reporter activity. | In vitro binding assays, site-directed mutagenesis, transgenic chick and mouse embryo reporter assays | Molecular and cellular biology | High | 16166636 |
| 2007 | IL-10 production stimulated by apoptotic cells is transcriptionally activated by PBX1b (pre-B cell leukemia transcription factor-1b) and PREP1 acting on an apoptotic-cell-response element (ACRE) in the human IL10 promoter; this regulation is dependent on p38 MAPK and partially on scavenger receptor CD36. | Reporter assay mapping of ACRE, EMSA, gene knockdown, biochemical and physiological experiments | Immunity | High | 18093541 |
| 2007 | Pbx1 is required at a stage between hematopoietic stem cell development and B-cell commitment; Pbx1-null ES cells fail to generate common lymphoid progenitors (CLPs) resulting in absence of B and NK cells; restoration of Pbx1 expression rescues B-cell development from CLPs. | Rag1-deficient blastocyst complementation assays, adoptive transfer experiments, conditional Pbx1 inactivation in pro-B cells | Blood | High | 17244677 |
| 2008 | Pbx1/Pbx2 govern axial skeletal patterning by controlling Polycomb and Hox expression and spatial distribution in the mesoderm, and Pax1/Pax9 expression in the sclerotome; compound Pbx1/Pbx2 loss-of-function results in a homogeneous vertebral column with loss of vertebral identity. | Pbx1/Pbx2 compound knockout mouse, molecular marker expression analysis, genetic epistasis | Developmental biology | High | 18691704 |
| 2009 | Pbx1 is a direct transcriptional target gene of Evi-1; Evi-1 overexpression activates Pbx1 promoter activity; Pbx1 knockdown inhibits Evi-1-induced bone marrow transformation, establishing Pbx1 as a downstream effector specifically required for Evi-1-mediated leukemogenesis. | Gene expression profiling, Pbx1 promoter analysis, RNAi knockdown, bone marrow transformation assay | Oncogene | Medium | 19767769 |
| 2009 | KLF4 and PBX1 directly bind the NANOG promoter (PBX1 at an upstream enhancer and proximal promoter) and cooperatively activate NANOG transcription; PBX1 cooperates with OCT4 and SOX2 in synergistic transactivation; knockdown of PBX1 or mutation of its binding motifs significantly reduces NANOG promoter activity in human ESCs. | Luciferase reporter assay, chromatin immunoprecipitation (ChIP), EMSA, shRNA knockdown, overexpression in hESCs | Stem cells (Dayton, Ohio) | High | 19522013 |
| 2010 | Pbx1 and Emx2 form heterodimers that bind specific DNA sequences; together they cooperatively activate transcription of Alx1 via a conserved upstream regulatory element; ChIP assays confirm Pbx1 and Emx2 bind in vivo to this Alx1 regulatory sequence, establishing a biochemical basis for Pbx1-Emx2 genetic interactions in scapula development. | Compound mutant mouse analysis, in vitro binding assays (Pbx1-Emx2 heterodimer formation), ChIP, transcriptional reporter assays | Development (Cambridge, England) | High | 20627960 |
| 2011 | HOXA10 and PBX1 form coregulatory complexes that are present at osteoblast-related gene promoters prior to their expression; PBX1 is associated with histone deacetylases and loss of PBX1 from the Osterix (Osx) promoter correlates with increased p300 recruitment and decreased H3K9 methylation, suggesting PBX1 attenuates HOXA10-mediated activation of osteoblast genes by maintaining a repressive chromatin state at their promoters. | ChIP, shRNA knockdown of PBX1, overexpression in preosteoblast cell lines, histone modification analysis | Cells, tissues, organs | Medium | 21597276 |
| 2011 | Pbx1a, Meis2d, and Klf4 form a cooperative transcriptional activation complex; Pbx1 and Meis2 can be recruited to DNA elements containing Klf4 binding sites with adjacent Meis and Pbx sites; this complex activates p15(Ink4a) and E-cadherin expression, and endogenous Meis2 or Pbx1 knockdown reduces p15 expression and increases S-phase entry. | Co-immunoprecipitation, reporter assays, DNA binding analysis, shRNA knockdown, cell cycle analysis | Molecular and cellular biology | Medium | 21746878 |
| 2012 | STAGA complex and its acetyltransferase subunit GCN5 directly interact with the E2A portion of E2A-PBX1 and acetylate E2A-PBX1, increasing its protein stability; the E3 ubiquitin ligase HDM2 potentiates E2A-PBX1 degradation, establishing GCN5-mediated acetylation as a post-translational mechanism regulating E2A-PBX1 stability. | Co-immunoprecipitation, in vitro acetylation assay, proteasome inhibitor experiments, GCN5 inhibitor treatment | Leukemia | Medium | 23044487 |
| 2012 | PBX1 directly regulates the transcription of MEOX1 in ovarian cancer cells; MEOX1 protein physically interacts with PBX1; MEOX1 inhibition phenocopies PBX1 suppression and ectopic MEOX1 rescues PBX1-withdrawal growth inhibition, establishing MEOX1 as a critical direct target and functional cofactor of PBX1 in ovarian cancer. | ChIP-chip (global PBX1 binding mapping), co-immunoprecipitation, shRNA knockdown, rescue experiment | PloS one | Medium | 22567123 |
| 2012 | E2A-PBX1 recruits the CBP/p300 coactivator through a PCET motif (helical LXXLL-containing AD1 domain) that binds the KIX domain of CBP; crystal structure of the PCET/KIX complex revealed the interacting residues; amino acid substitutions preventing helix formation abrogate KIX binding and bone marrow immortalization by E2A-PBX1. | NMR/crystal structure of PCET-KIX complex, circular dichroism, mutagenesis, bone marrow immortalization assays | Blood | High | 22972988 |
| 2006 | A single conserved leucine residue (L20) within the LXXLL motif of the E2A AD1 domain (PCET) is required for interaction with the KIX domain of CBP; substitution of L20 impairs leukemia induction in mice after bone marrow transplantation with E2A-PBX1-expressing cells. | Circular dichroism spectroscopy, in vitro KIX binding assays, murine bone marrow transplantation leukemia model | Molecular and cellular biology | High | 16914730 |
| 2015 | PTBP1 represses inclusion of Pbx1 exon 7 in ESCs, suppressing expression of the neuronal Pbx1a isoform; CRISPR-Cas9 deletion of exon 7 regulatory elements induced Pbx1a expression in ESCs and activated transcription of neuronal genes, establishing PTBP1-regulated alternative splicing as a mechanism controlling Pbx1 isoform-dependent neuronal transcriptional programs. | CRISPR-Cas9 deletion of splicing regulatory elements, RNA-seq, splice isoform-specific assays | eLife | High | 26705333 |
| 2016 | PBX1 controls a transcriptional network in midbrain dopaminergic neurons by directly repressing Onecut2 (to inhibit lateral fates) and directly activating Pitx3 (to promote dopaminergic development) and Nfe2l1 (to protect from oxidative stress); this PBX1-directed program is sufficient to generate midbrain dopaminergic neurons from human stem cells. | ChIP-seq, reporter assays, gain/loss-of-function in mouse embryos and human stem cell differentiation | The EMBO journal | High | 27354364 |
| 2016 | PBX1 functions as a pioneer factor that mediates ERα binding in response to EGF signaling in breast cancer; PBX1 directly regulates a subset of EGF-ERα target genes associated with aggressive breast tumors. | ChIP, gene expression profiling, PBX1 overexpression/knockdown in breast cancer cells | Oncotarget | Medium | 26215677 |
| 2016 | PBX1 directly binds the STAT3 promoter and positively regulates STAT3 transcription in ovarian cancer; PBX1-driven STAT3 expression mediates chemoresistance and cancer stem cell-like properties; inhibition of STAT3/JAK2 sensitized platinum-resistant cells to carboplatin in vivo. | ChIP (genome-wide), reporter assays, shRNA knockdown, in vivo xenograft experiments | Cancer research | Medium | 27590741 |
| 2016 | E2A-PBX1 directly binds promoter regions and activates transcription of ZAP70, SYK, and LCK, which encode kinases upstream of PLCγ2, resulting in hyperactivation of PLCγ2 signaling in pre-B ALL; depletion of PLCγ2 or upstream kinases reduces proliferation and pPLCγ2 levels. | ChIP-seq, gene expression analysis, siRNA knockdown, kinase inhibitor experiments, in vivo leukemia model | Cancer research | High | 27758892 |
| 2018 | SETDB2 is a direct transcriptional target of E2A-PBX1; SETDB2 suppresses the cell-cycle inhibitor CDKN2C through histone H3K9 tri-methylation, establishing an oncogenic E2A-PBX1→SETDB2→H3K9me3→CDKN2C repression pathway in pre-BCR+ ALL. | ChIP, histone methylation analysis, SETDB2 knockdown, in vivo leukemia assays | Cell reports | High | 29694893 |
| 2019 | PBX1 directly regulates CD44 expression via two PBX1 binding sites in the CD44 promoter; the lupus-associated dominant-negative PBX1-d isoform drives higher CD44 expression than the normal PBX1-b isoform and shows enhanced recruitment of co-factor MEIS (but not PREP1) compared to PBX1-b. | Chromatin immunoprecipitation, luciferase reporter assays with binding site mutations, co-factor pull-down assays | Molecular immunology | Medium | 28257976 |
| 2019 | The PBX1 p.Arg235Gln missense mutation within the nuclear localization signal of the TALE homeodomain impairs nuclear localization of PBX1 and abolishes its physical interaction with the testis-determination proteins CBX2 and EMX2, providing a mechanism for 46,XY gonadal dysgenesis. | Subcellular localization assays, co-immunoprecipitation of mutant vs. wild-type PBX1 with CBX2 and EMX2 | Human mutation | Medium | 31058389 |
| 2020 | The PBX1 p.R184P missense variant decreases PBX1 protein levels (despite elevated mRNA) and causes multiple congenital anomalies in a CRISPR-Cas9 knock-in mouse model, including congenital heart defects, adrenal aplasia, spleen aplasia, and renal/gonadal defects in homozygotes. | CRISPR-Cas9 gene-edited mouse model, protein and mRNA quantification, developmental phenotype analysis | Human molecular genetics | High | 31625560 |
| 2021 | E2A-PBX1 recruits MED1 (Mediator subunit) directly via interaction between MED1 and an E2A activation domain; MED1 is specifically required for E2A-PBX1-dependent gene activation; E2A-PBX1 is also recruited to target promoters through direct interaction with DNA-bound RUNX1, further stabilized by EBF1. | Direct interaction assays, CRISPR/Cas9 MED1 depletion, transcriptome and cistrome analysis, biochemical co-factor interaction assays | Proceedings of the National Academy of Sciences of the United States of America | High | 33542097 |
| 2021 | PBX1 directly regulates a FOXM1-dependent transcriptional program in multiple myeloma by binding to reprogrammed superenhancers; pharmacological disruption of the PBX1-FOXM1 axis with a novel PBX1 small-molecule inhibitor (T417) that docks to the PBX1-DNA interface is selectively toxic against chr1q-amplified myeloma cells. | Multi-omics (ChIP-seq, RNA-seq), 3D chromatin analysis, T417 small-molecule docking and functional assays | Blood | Medium | 35015835 |
| 2021 | Pbx1 controls MPN progression driven by JAK2V617F; in the absence of Pbx1, JAK2V617F mice do not develop thrombocythemia, granulocytosis, splenic myeloid metaplasia, or cytokine-independent growth; the aberrant transcriptome in stem/progenitor cells from MPN models is reverted by Pbx1 inactivation. | Conditional compound JAK2V617F/Pbx1-knockout mouse (JP strain), RNA-seq of stem/progenitor cells, functional colony assays | Stem cell reports | High | 34678207 |
| 2021 | PBX1 small-molecule inhibitor T417, designed to dock to the PBX1-DNA interface, suppresses self-renewal and proliferation of high-PBX1 cancer cells and re-sensitizes platinum-resistant ovarian tumors to carboplatin in cell-based assays. | Computational docking to PBX1-DNA interface, cell proliferation assays, platinum-resistance rescue experiments | iScience | Medium | 34816098 |
| 2022 | METTL3 binds and stabilizes PBX1 mRNA through m6A modification, increasing PBX1 protein levels; PBX1 in turn acts as a transcription factor inducing GCH1 expression (confirmed by ChIP), elevating BH4 levels to promote gastric cancer progression. | Me-RIP-seq, ChIP, Western blot, siRNA knockdown, xenograft models | Cancer communications (London, England) | Medium | 35261206 |
| 2023 | TRIM26 directly binds PBX1 and mediates its K48-linked polyubiquitination and proteasomal degradation via its C-terminal RING domain; TRIM26-mediated PBX1 degradation downregulates PBX1 downstream target genes including RNF6. | Affinity purification-coupled tandem MS/MS, co-immunoprecipitation, in vitro ubiquitination assay, RING domain deletion mutants | International journal of biological sciences | Medium | 37324936 |
| 2023 | PBX1/2 and HAND2 collaborate to regulate a limb-specific gene regulatory network (GRN) in posterior hindlimb mesenchyme; genome-wide PBX1 binding profiling across multiple embryonic tissues reveals HAND2 interacts with subsets of PBX-bound regions to confer limb-specific transcriptional specificity; tissue-specific and temporally controlled loss-of-function of PBX1/2 or HAND2 generates similar limb phenotypes. | Tissue-specific conditional knockout mice, ATAC-seq, ChIP-seq, RNA-seq, multi-omics GRN reconstruction | Nature communications | High | 37414772 |
| 2003 | PBX1 and PREP1 directly bind a PBX consensus element (TGATTGAC) conserved in the long terminal repeat of Moloney murine leukemia virus; overexpression of PBX1 and PREP1 enhances viral transcription, and blocking PBX1 protein synthesis significantly decreases MLV transcription. | Gel shift assays, overexpression experiments, antisense-mediated knockdown of PBX1 | Molecular and cellular biology | Medium | 12529389 |
| 2023 | Pbx1 directly regulates genetic programs controlling B cell proliferation and apoptosis pathways; Pbx1 deficiency in B cells leads to excessive germinal center responses, increased plasma cell differentiation, and autoantibody production in a lupus model; CUT&TAG and ChIP-qPCR identified Pbx1 binding to promoters of proliferation and apoptosis pathway genes. | B cell-specific Pbx1 knockout mice, RNA-seq, CUT&TAG, ChIP-qPCR, lupus Bm12 model, PBX1 overexpression in SLE patient B cells | Arthritis & rheumatology (Hoboken, N.J.) | Medium | 36862399 |
Source papers
Stage 0 corpus · 100 papers · ranked by NIH iCite citations
| Year | Title | Journal | Citations | PMID |
|---|---|---|---|---|
| 1999 | Structure of a HoxB1-Pbx1 heterodimer bound to DNA: role of the hexapeptide and a fourth homeodomain helix in complex formation. | Cell | 279 | 10052460 |
| 1996 | Cooperative activation of Hoxa and Pbx1-related genes in murine myeloid leukaemias. | Nature genetics | 277 | 8563752 |
| 1995 | Meis1, a PBX1-related homeobox gene involved in myeloid leukemia in BXH-2 mice. | Molecular and cellular biology | 272 | 7565694 |
| 1991 | PBX2 and PBX3, new homeobox genes with extensive homology to the human proto-oncogene PBX1. | Molecular and cellular biology | 272 | 1682799 |
| 2001 | Requirement for Pbx1 in skeletal patterning and programming chondrocyte proliferation and differentiation. | Development (Cambridge, England) | 248 | 11566859 |
| 2002 | Differential expression of Hox, Meis1, and Pbx1 genes in primitive cells throughout murine hematopoietic ontogeny. | Experimental hematology | 224 | 11823037 |
| 2007 | Interleukin-10 expression in macrophages during phagocytosis of apoptotic cells is mediated by homeodomain proteins Pbx1 and Prep-1. | Immunity | 195 | 18093541 |
| 1993 | Chimeric homeobox gene E2A-PBX1 induces proliferation, apoptosis, and malignant lymphomas in transgenic mice. | Cell | 183 | 8104101 |
| 2002 | Pbx1 inactivation disrupts pancreas development and in Ipf1-deficient mice promotes diabetes mellitus. | Nature genetics | 158 | 11912494 |
| 1993 | E2A-Pbx1, the t(1;19) translocation protein of human pre-B-cell acute lymphocytic leukemia, causes acute myeloid leukemia in mice. | Molecular and cellular biology | 154 | 8093327 |
| 2003 | Pbx1 is essential for adrenal development and urogenital differentiation. | Genesis (New York, N.Y. : 2000) | 132 | 14595835 |
| 2001 | The Hox cofactor and proto-oncogene Pbx1 is required for maintenance of definitive hematopoiesis in the fetal liver. | Blood | 129 | 11468159 |
| 2015 | The splicing regulator PTBP1 controls the activity of the transcription factor Pbx1 during neuronal differentiation. | eLife | 124 | 26705333 |
| 2009 | KLF4 and PBX1 directly regulate NANOG expression in human embryonic stem cells. | Stem cells (Dayton, Ohio) | 110 | 19522013 |
| 2006 | Two-step regulation of Ad4BP/SF-1 gene transcription during fetal adrenal development: initiation by a Hox-Pbx1-Prep1 complex and maintenance via autoregulation by Ad4BP/SF-1. | Molecular and cellular biology | 109 | 16705164 |
| 2005 | A Pbx1-dependent genetic and transcriptional network regulates spleen ontogeny. | Development (Cambridge, England) | 105 | 15944191 |
| 2016 | A PBX1 transcriptional network controls dopaminergic neuron development and is impaired in Parkinson's disease. | The EMBO journal | 98 | 27354364 |
| 1995 | The hexapeptide LFPWMR in Hoxb-8 is required for cooperative DNA binding with Pbx1 and Pbx2 proteins. | Proceedings of the National Academy of Sciences of the United States of America | 97 | 7568094 |
| 2003 | Pbx1 regulates nephrogenesis and ureteric branching in the developing kidney. | Developmental biology | 93 | 12591246 |
| 1997 | E2a-Pbx1 induces aberrant expression of tissue-specific and developmentally regulated genes when expressed in NIH 3T3 fibroblasts. | Molecular and cellular biology | 88 | 9032278 |
| 1994 | Fusion with E2A alters the transcriptional properties of the homeodomain protein PBX1 in t(1;19) leukemias. | Oncogene | 80 | 8183558 |
| 2005 | Hoxb1 enhancer and control of rhombomere 4 expression: complex interplay between PREP1-PBX1-HOXB1 binding sites. | Molecular and cellular biology | 73 | 16166636 |
| 1998 | Cellular proliferation and transformation induced by HOXB4 and HOXB3 proteins involves cooperation with PBX1. | Oncogene | 72 | 9692548 |
| 2008 | Identification of Pbx1, a potential oncogene, as a Notch3 target gene in ovarian cancer. | Cancer research | 64 | 18974129 |
| 2016 | Ovarian Cancer Chemoresistance Relies on the Stem Cell Reprogramming Factor PBX1. | Cancer research | 62 | 27590741 |
| 2015 | Comparative genomics reveals multistep pathogenesis of E2A-PBX1 acute lymphoblastic leukemia. | The Journal of clinical investigation | 57 | 26301816 |
| 2007 | B-cell development fails in the absence of the Pbx1 proto-oncogene. | Blood | 55 | 17244677 |
| 2009 | Pbx1 is a downstream target of Evi-1 in hematopoietic stem/progenitors and leukemic cells. | Oncogene | 54 | 19767769 |
| 2017 | A tale of TALE, PREP1, PBX1, and MEIS1: Interconnections and competition in cancer. | BioEssays : news and reviews in molecular, cellular and developmental biology | 53 | 28322463 |
| 2012 | GCN5 acetylates and regulates the stability of the oncoprotein E2A-PBX1 in acute lymphoblastic leukemia. | Leukemia | 53 | 23044487 |
| 2010 | Scapula development is governed by genetic interactions of Pbx1 with its family members and with Emx2 via their cooperative control of Alx1. | Development (Cambridge, England) | 53 | 20627960 |
| 2022 | m6 A-mediated regulation of PBX1-GCH1 axis promotes gastric cancer proliferation and metastasis by elevating tetrahydrobiopterin levels. | Cancer communications (London, England) | 52 | 35261206 |
| 1997 | The Hox cooperativity motif of the chimeric oncoprotein E2a-Pbx1 is necessary and sufficient for oncogenesis. | Molecular and cellular biology | 52 | 8972188 |
| 2009 | GAS6/Mer axis regulates the homing and survival of the E2A/PBX1-positive B-cell precursor acute lymphoblastic leukemia in the bone marrow niche. | Experimental hematology | 51 | 19922767 |
| 1994 | A cAMP-regulatory sequence (CRS1) of CYP17 is a cellular target for the homeodomain protein Pbx1. | The Journal of biological chemistry | 47 | 7913464 |
| 2016 | Idelalisib sensitivity and mechanisms of disease progression in relapsed TCF3-PBX1 acute lymphoblastic leukemia. | Leukemia | 46 | 27461063 |
| 2015 | The pioneer factor PBX1 is a novel driver of metastatic progression in ERα-positive breast cancer. | Oncotarget | 46 | 26215677 |
| 2011 | Epigenetic regulation of early osteogenesis and mineralized tissue formation by a HOXA10-PBX1-associated complex. | Cells, tissues, organs | 46 | 21597276 |
| 2017 | Overexpression of lipid metabolism genes and PBX1 in the contralateral breasts of women with estrogen receptor-negative breast cancer. | International journal of cancer | 45 | 28263391 |
| 2006 | PLZF regulates Pbx1 transcription and Pbx1-HoxC8 complex leads to androgen-independent prostate cancer proliferation. | The Prostate | 45 | 16637071 |
| 1999 | Fibroblast growth factor-8 expression is regulated by intronic engrailed and Pbx1-binding sites. | The Journal of biological chemistry | 45 | 10026229 |
| 2019 | Wnt5a and ROR1 activate non-canonical Wnt signaling via RhoA in TCF3-PBX1 acute lymphoblastic leukemia and highlight new treatment strategies via Bcl-2 co-targeting. | Oncogene | 43 | 30631148 |
| 2009 | Ectopic Meis1 expression in the mouse limb bud alters P-D patterning in a Pbx1-independent manner. | The International journal of developmental biology | 43 | 19247936 |
| 2011 | Cooperative transcriptional activation by Klf4, Meis2, and Pbx1. | Molecular and cellular biology | 42 | 21746878 |
| 2019 | NANOG Attenuates Hair Follicle-Derived Mesenchymal Stem Cell Senescence by Upregulating PBX1 and Activating AKT Signaling. | Oxidative medicine and cellular longevity | 41 | 31885790 |
| 2020 | MicroRNA-181 regulates the development of Ossification of Posterior longitudinal ligament via Epigenetic Modulation by targeting PBX1. | Theranostics | 40 | 32685001 |
| 2012 | Identification of PBX1 target genes in cancer cells by global mapping of PBX1 binding sites. | PloS one | 39 | 22567123 |
| 2008 | Pbx1/Pbx2 govern axial skeletal development by controlling Polycomb and Hox in mesoderm and Pax1/Pax9 in sclerotome. | Developmental biology | 38 | 18691704 |
| 2024 | Exosomal lncRNA NEAT1 Inhibits NK-Cell Activity to Promote Multiple Myeloma Cell Immune Escape via an EZH2/PBX1 Axis. | Molecular cancer research : MCR | 37 | 37889101 |
| 1996 | The divergent homeobox gene PBX1 is expressed in the postnatal subventricular zone and interneurons of the olfactory bulb. | The Journal of neuroscience : the official journal of the Society for Neuroscience | 36 | 8622127 |
| 1996 | DNA-binding by oncoprotein E2a-Pbx1 is important for blocking differentiation but dispensable for fibroblast transformation. | Oncogene | 35 | 8552391 |
| 1995 | Localization of Pbx1 transcripts in developing rat embryos. | Mechanisms of development | 35 | 7547467 |
| 2012 | Structural basis of CBP/p300 recruitment in leukemia induction by E2A-PBX1. | Blood | 34 | 22972988 |
| 2001 | Estrogen-dependent E2a/Pbx1 myeloid cell lines exhibit conditional differentiation that can be arrested by other leukemic oncoproteins. | Blood | 32 | 11588024 |
| 2020 | A novel c-Kit/phospho-prohibitin axis enhances ovarian cancer stemness and chemoresistance via Notch3-PBX1 and β-catenin-ABCG2 signaling. | Journal of biomedical science | 31 | 32169072 |
| 2016 | E2A-PBX1 Remodels Oncogenic Signaling Networks in B-cell Precursor Acute Lymphoid Leukemia. | Cancer research | 31 | 27758892 |
| 2022 | Systems medicine dissection of chr1q-amp reveals a novel PBX1-FOXM1 axis for targeted therapy in multiple myeloma. | Blood | 30 | 35015835 |
| 2021 | PBX1: a key character of the hallmarks of cancer. | Journal of molecular medicine (Berlin, Germany) | 29 | 34529123 |
| 2018 | SETDB2 Links E2A-PBX1 to Cell-Cycle Dysregulation in Acute Leukemia through CDKN2C Repression. | Cell reports | 29 | 29694893 |
| 2020 | Functional characterization of a novel PBX1 de novo missense variant identified in a patient with syndromic congenital heart disease. | Human molecular genetics | 28 | 31625560 |
| 2018 | PBX1 promotes the cell proliferation via JAK2/STAT3 signaling in clear cell renal carcinoma. | Biochemical and biophysical research communications | 28 | 29678569 |
| 2008 | BCR-ABL, ETV6-RUNX1 and E2A-PBX1: prevalence of the most common acute lymphoblastic leukemia fusion genes in Mexican patients. | Leukemia research | 28 | 18455790 |
| 2008 | Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible genetic association with bone mineral density variation. | Human molecular genetics | 28 | 19064610 |
| 2014 | Direct and indirect targets of the E2A-PBX1 leukemia-specific fusion protein. | PloS one | 27 | 24503810 |
| 2014 | Outcome of TCF3-PBX1 positive pediatric acute lymphoblastic leukemia patients in Japan: a collaborative study of Japan Association of Childhood Leukemia Study (JACLS) and Children's Cancer and Leukemia Study Group (CCLSG). | Cancer medicine | 26 | 24578304 |
| 2004 | E2a/Pbx1 induces the rapid proliferation of stem cell factor-dependent murine pro-T cells that cause acute T-lymphoid or myeloid leukemias in mice. | Molecular and cellular biology | 26 | 14729970 |
| 2021 | Mediator subunit MED1 is required for E2A-PBX1-mediated oncogenic transcription and leukemic cell growth. | Proceedings of the National Academy of Sciences of the United States of America | 25 | 33542097 |
| 2003 | Identification of homeodomain proteins, PBX1 and PREP1, involved in the transcription of murine leukemia virus. | Molecular and cellular biology | 25 | 12529389 |
| 1999 | EB-1, a tyrosine kinase signal transduction gene, is transcriptionally activated in the t(1;19) subset of pre-B ALL, which express oncoprotein E2a-Pbx1. | Oncogene | 25 | 10490826 |
| 2017 | uc.38 induces breast cancer cell apoptosis via PBX1. | American journal of cancer research | 24 | 29312798 |
| 1996 | Selective repression of transcriptional activators by Pbx1 does not require the homeodomain. | Proceedings of the National Academy of Sciences of the United States of America | 24 | 8552663 |
| 2015 | Associations of Polymorphisms in WNT9B and PBX1 with Mayer-Rokitansky-Küster-Hauser Syndrome in Chinese Han. | PloS one | 23 | 26075712 |
| 1997 | Monoclonal antibodies specific to the acute lymphoblastic leukemia t(1;19)-associated E2A/pbx1 chimeric protein: characterization and diagnostic utility. | Blood | 23 | 9108411 |
| 1997 | Expression of BCR-ABL, E2A-PBX1, and MLL-AF4 fusion transcripts in newly diagnosed children with acute lymphoblastic leukemia: a Children's Cancer Group initiative. | Leukemia & lymphoma | 23 | 9250788 |
| 2008 | Oncogenic HoxB7 requires TALE cofactors and is inactivated by a dominant-negative Pbx1 mutant in a cell-specific manner. | Cancer letters | 22 | 18378073 |
| 2021 | The clinical outcomes and genomic landscapes of acute lymphoblastic leukemia patients with E2A-PBX1: A 10-year retrospective study. | American journal of hematology | 21 | 34406703 |
| 2006 | Critical role for a single leucine residue in leukemia induction by E2A-PBX1. | Molecular and cellular biology | 21 | 16914730 |
| 2023 | TRIM26 promotes non-small cell lung cancer survival by inducing PBX1 degradation. | International journal of biological sciences | 20 | 37324936 |
| 2022 | Targeting SPHK1/PBX1 Axis Induced Cell Cycle Arrest in Non-Small Cell Lung Cancer. | International journal of molecular sciences | 20 | 36361531 |
| 2021 | Establishment of the TALE-code reveals aberrantly activated homeobox gene PBX1 in Hodgkin lymphoma. | PloS one | 20 | 33539429 |
| 2021 | Development of small molecule inhibitors targeting PBX1 transcription signaling as a novel cancer therapeutic strategy. | iScience | 20 | 34816098 |
| 2001 | The HoxB1 hexapeptide is a prefolded domain: implications for the Pbx1/Hox interaction. | Protein science : a publication of the Protein Society | 20 | 11369863 |
| 1993 | Expression of identical E2A/PBX1 fusion transcripts occurs in both pre-B and early pre-B immunological subtypes of childhood acute lymphoblastic leukemia. | Leukemia | 19 | 8255105 |
| 2013 | Frequency of the ETV6-RUNX1, BCR-ABL1, TCF3-PBX1, and MLL-AFF1 fusion genes in Guatemalan pediatric acute lymphoblastic leukemia patients and their ethnic associations. | Cancer genetics | 18 | 23859904 |
| 2008 | Evidence for Hox and E2A-PBX1 collaboration in mouse T-cell leukemia. | Oncogene | 18 | 18679416 |
| 1997 | Hyperdiploidy and E2A-PBX1 fusion in an adult with t(1;19)+ acute lymphoblastic leukemia: case report and review of the literature. | Genes, chromosomes & cancer | 18 | 9408756 |
| 2023 | Involvement of Transcriptional Factor Pbx1 in Peripheral B Cell Homeostasis to Constrain Lupus Autoimmunity. | Arthritis & rheumatology (Hoboken, N.J.) | 17 | 36862399 |
| 2021 | MicroRNA-141-3p inhibits the progression of oral squamous cell carcinoma via targeting PBX1 through the JAK2/STAT3 pathway. | Experimental and therapeutic medicine | 17 | 34976139 |
| 2020 | Paternal mosaicism for a novel PBX1 mutation associated with recurrent perinatal death: Phenotypic expansion of the PBX1-related syndrome. | American journal of medical genetics. Part A | 17 | 32141698 |
| 2024 | PBX1 as a novel master regulator in cancer: Its regulation, molecular biology, and therapeutic applications. | Biochimica et biophysica acta. Reviews on cancer | 16 | 38341110 |
| 2022 | PBX1-SIRT1 Positive Feedback Loop Attenuates ROS-Mediated HF-MSC Senescence and Apoptosis. | Stem cell reviews and reports | 16 | 35962175 |
| 2022 | The TALE never ends: A comprehensive overview of the role of PBX1, a TALE transcription factor, in human developmental defects. | Human mutation | 15 | 35451537 |
| 2016 | Regulation of the miRNA expression by TEL/AML1, BCR/ABL, MLL/AF4 and TCF3/PBX1 oncoproteins in acute lymphoblastic leukemia (Review). | Oncology reports | 15 | 27431573 |
| 2023 | A spatio-temporally constrained gene regulatory network directed by PBX1/2 acquires limb patterning specificity via HAND2. | Nature communications | 14 | 37414772 |
| 2021 | PBX1-directed stem cell transcriptional program drives tumor progression in myeloproliferative neoplasm. | Stem cell reports | 14 | 34678207 |
| 2019 | The TALE homeodomain of PBX1 is involved in human primary testis-determination. | Human mutation | 14 | 31058389 |
| 2017 | The PBX1 lupus susceptibility gene regulates CD44 expression. | Molecular immunology | 14 | 28257976 |
| 2017 | A hydrophobic residue in the TALE homeodomain of PBX1 promotes epithelial-to-mesenchymal transition of gastric carcinoma. | Oncotarget | 14 | 28514754 |
| 2013 | Detection of E2A-PBX1 fusion transcripts in human non-small-cell lung cancer. | Journal of experimental & clinical cancer research : CR | 14 | 23688269 |
| 2009 | Essential role for Pbx1 in corneal morphogenesis. | Investigative ophthalmology & visual science | 13 | 19797217 |