Affinage

MEIS1

Homeobox protein Meis1 · UniProt O00470

Length
390 aa
Mass
43.0 kDa
Annotated
2026-06-10
100 papers in source corpus 48 papers cited in narrative 48 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

MEIS1 is a TALE-class homeodomain transcription factor that operates as a combinatorial DNA-binding partner, dimerizing with PBX proteins and forming heterodimeric and trimeric complexes with AbdB-like HOX group 9–13 proteins (HOXA9, HOXA10, HOXA11, HOXD12, HOXB13) on composite recognition sites to activate target gene transcription (PMID:9343407, PMID:9405651, PMID:10082572). Cooperative assembly on DNA stabilizes the HOX-MEIS1 complex and, distinct from HOX-PBX interactions, the MEIS1-PBX interface does not require the conserved N-terminal tryptophan motif (PMID:9343407, PMID:9405651, PMID:9525891); MEIS1 also promotes nuclear import of PBX1 to control proximal limb identity, a patterning function that can be PBX1-independent in some contexts (PMID:10586884, PMID:19247936). In hematopoiesis MEIS1 is essential for definitive HSC specification in the AGM, megakaryocyte production, and vascular patterning, acting upstream of regulators including Gfi1 and gata1 (PMID:14713950, PMID:15882575, PMID:20123093, PMID:20516218), and it sustains HSC quiescence by restricting reactive oxygen species through a directly activated HLF/hypoxia-response axis (PMID:23091297, PMID:25740828). MEIS1 is a rate-limiting driver of HOX- and MLL-rearranged acute myeloid leukemia, where it programs leukemic stem cell self-renewal and differentiation arrest through cooperatively assembled MEIS1-PBX/HOX-PBX complexes that co-occupy and activate target promoters; its transforming activity requires the PBX-interaction motif, the homeodomain, and a C-terminal transactivation domain, and direct targets include FLT3, cyclin D3, SYTL1, Trib2, and HLF (PMID:11113197, PMID:14701735, PMID:15755900, PMID:16648484, PMID:16469876, PMID:17942707, PMID:20237320, PMID:27018596). PBX3/MEIS1 co-expression alone is sufficient to transform hematopoietic progenitors and induce AML (PMID:26747896). Beyond hematopoiesis, MEIS1 enforces cardiomyocyte cell-cycle arrest by transcriptionally activating the CDK inhibitors p15, p16, and p21 and shapes the cardiomyocyte glycolytic-versus-oxidative metabolic program (PMID:23594737, PMID:30884246), and it controls retinal and cerebellar progenitor proliferation and differentiation through cyclin D1/D3, c-myc, and a Pax6-BMP-Atoh1 cascade (PMID:18216175, PMID:18216174, PMID:29317485, PMID:26253404). MEIS1 protein levels are tuned post-translationally: PBX3 binding stabilizes MEIS1 against ubiquitin-proteasome degradation, CDC20-mediated ubiquitination (countered by PPM1K) destabilizes it, and PREP1/PKNOX1 lowers MEIS1 stability by competitively sequestering PBX1 (PMID:25911551, PMID:24578510, PMID:29719258).

Mechanistic history

Synthesis pass · year-by-year structured walk · 23 steps
  1. 1995 Medium

    Established MEIS1 as a homeobox oncogene by identifying it as a recurrent retroviral integration target in myeloid leukemia and placing it in the TALE family related to PBX/exd.

    Evidence Retroviral insertion site cloning and cDNA sequencing in BXH-2 myeloid leukemias

    PMID:7565694

    Open questions at the time
    • No demonstration of DNA-binding partners or target genes at this stage
    • Leukemogenic mechanism inferred only from integration frequency
  2. 1997 High

    Defined MEIS1's biochemical mode of action as a partner-selective DNA-binding factor that heterodimerizes specifically with AbdB-like HOX proteins and with PBX1 through a unique interaction surface.

    Evidence EMSA with composite sites, paralog-specificity tests, and domain-mapping mutagenesis in vitro

    PMID:9343407 PMID:9405651

    Open questions at the time
    • In vitro binding did not establish in vivo target genes
    • Functional consequence of complex formation on transcription not yet shown
  3. 1998 High

    Confirmed that endogenous MEIS1-PBX1 complexes form on a physiological target sequence and that the cooperative binding mechanism is evolutionarily conserved.

    Evidence Affinity purification of endogenous complexes from adrenal nuclear extracts plus EMSA and mutagenesis on the CYP17 CRS1 element

    PMID:9525891

    Open questions at the time
    • Direct transcriptional output at the endogenous CYP17 locus not measured
    • Single tissue context
  4. 1999 High

    Showed MEIS1 nucleates trimeric HOX-PBX-MEIS1 complexes in leukemia nuclei and controls PBX1 nuclear import to direct limb patterning, linking complex assembly to in vivo developmental and oncogenic function.

    Evidence Co-IP and nuclear co-localization in myeloid cells; ectopic expression in chick and Drosophila with PBX1 immunolocalization

    PMID:10082572 PMID:10586884

    Open questions at the time
    • Target genes downstream of the trimeric complex not yet identified
    • Mechanism coupling nuclear import to transcription incomplete
  5. 1999 High

    Broadened MEIS1's partner repertoire by showing PBX-MEIS1/PREP1 complexes cooperate with myogenic bHLH factors to remodel chromatin and activate differentiation genes.

    Evidence Cooperative EMSA, tryptophan-motif mutagenesis, and in vivo chromatin remodeling at the Myogenin promoter

    PMID:10471746

    Open questions at the time
    • Direct MEIS1 occupancy at myogenic promoters in vivo not shown
    • Relative contribution of MEIS1 versus PREP1 not separated
  6. 2001 High

    Demonstrated MEIS1 has transformation-specific oncogenic function beyond PBX nuclear localization by showing it accelerates HOX-induced AML where the redundant PBX-retention factor PREP1 cannot.

    Evidence Retroviral bone marrow transduction/transplantation with HOXA9/HOXB3 and PREP1 substitution controls

    PMID:11113197

    Open questions at the time
    • Molecular basis of the transformation-specific activity unresolved
    • Direct leukemic target genes not yet defined
  7. 2004 High

    Established MEIS1 as required in vivo for definitive hematopoiesis, megakaryopoiesis, and vascular patterning, and showed HOXA9+MEIS1 co-expression is sufficient to replace an MLL fusion for immortalization.

    Evidence Meis1 knockout mice with transplantation/colony assays; inducible MLL-ENL replacement system

    PMID:14701735 PMID:14713950

    Open questions at the time
    • Embryonic lethality limits adult HSC analysis in constitutive KO
    • Direct transcriptional targets driving immortalization not yet mapped
  8. 2004 Medium

    Revealed MEIS1 overexpression triggers caspase-dependent apoptosis that HOXA9 co-expression suppresses, linking complex partnership to cell-survival output and requiring homeodomain and PBX-interaction motifs.

    Evidence Retroviral overexpression with caspase inhibitors and domain-deletion mutants

    PMID:15479723

    Open questions at the time
    • Pro-apoptotic target genes not identified
    • Single-lab functional study
  9. 2005 High

    Defined MEIS1 as a programmer of leukemic stem cell potential and identified its first direct kinase target, showing a transcription-factor oncoprotein establishing tyrosine-kinase oncoprotein FLT3 expression.

    Evidence Domain-deletion mutagenesis with in vivo leukemia transplantation and gene expression analysis; AGM/embryo gene inactivation studies

    PMID:15755900 PMID:15882575

    Open questions at the time
    • Direct promoter occupancy of FLT3 not yet shown at this stage
    • C-terminal domain mechanism undefined
  10. 2006 High

    Established that MEIS1 leukemogenesis requires co-occupancy of MEIS1-PBX and HOX-PBX complexes on target promoters and dissected the three essential domains needed for transformation.

    Evidence ChIP at the Flt3 promoter, VP16/engrailed domain-swap fusions, and systematic domain mutagenesis with leukemia transplantation

    PMID:16469876 PMID:16648484

    Open questions at the time
    • Full set of co-occupied target genes not yet genome-wide
    • Hoxa autoactivation mechanism not detailed
  11. 2007 High

    Established MEIS1 as an essential, rate-limiting and dose-dependent regulator of MLL leukemia stem cell self-renewal, codependent on PBX2/PBX3.

    Evidence Conditional KO, shRNA, and dominant-negative approaches with serial transplantation and LSC frequency analysis

    PMID:17942707

    Open questions at the time
    • Quantitative target genes mediating dose effect not enumerated
    • Relative PBX2 versus PBX3 contributions not separated
  12. 2008 High

    Expanded the direct MEIS1 leukemic target set by ChIP and identified domain-specific requirements, while linking MEIS1 to additional roles in cell-cycle control of progenitors and to its own regulation by miR-155.

    Evidence ChIP across multiple loci with NUP98-HOXD13 model; zebrafish/chick/mouse retinal loss-of-function with cyclin D1/D3 and c-myc readouts; miR-155 3'-UTR reporter assays

    PMID:17227832 PMID:18216174 PMID:18216175 PMID:18375036 PMID:18950466

    Open questions at the time
    • N-terminal domain mechanism for Flt3 upregulation undefined
    • Whether retinal and leukemic target programs share regulatory logic unknown
  13. 2009 High

    Clarified the regulatory hierarchy by showing HOXA9 induces Meis1 only indirectly through direct activation of CREB1 and PKNOX1 rather than direct promoter binding.

    Evidence ChIP (negative for direct binding), Hoxa9-/- genetics, and CREB1 rescue in bone marrow

    PMID:19620287

    Open questions at the time
    • Additional upstream inputs into Meis1 transcription not exhaustively mapped
  14. 2010 High

    Connected MEIS1 transcriptional control directly to cell-cycle progression and to early hematopoietic and erythroid programs through specific target loci.

    Evidence ChIP and rescue at cyclin D3 (pRb axis); Gfi1 enhancer ChIP/transgenic assay; zebrafish epistasis placing Meis1/Pbx upstream of gata1

    PMID:20123093 PMID:20237320 PMID:20516218

    Open questions at the time
    • Combined contribution of these targets to a unified program not integrated
    • Cardiac and metabolic cell-cycle roles not yet examined
  15. 2011 High

    Linked MEIS1 to iron homeostasis and restless legs syndrome biology and demonstrated genome-wide MEIS1/HOX target overlap underlying MN1-driven leukemia susceptibility.

    Evidence C. elegans RNAi and human RLS brain expression for ferritin/DMT1; ChIP-seq and progenitor complementation in MN1 leukemia

    PMID:21710629 PMID:21741595

    Open questions at the time
    • Mechanism connecting MEIS1 to ferritin regulation undefined
    • Whether iron regulation reflects direct transcriptional targets unknown
  16. 2013 High

    Established MEIS1 as a transcriptional enforcer of cardiomyocyte cell-cycle arrest and revealed a repressive regulatory circuit controlling its own expression in erythroid cells.

    Evidence Reciprocal cardiomyocyte gain/loss-of-function in vivo with p15/p16/p21 readouts; Gfi1b/LSD1/CoREST ChIP and reporter mutagenesis on the Meis1 promoter

    PMID:23308270 PMID:23594737

    Open questions at the time
    • Direct MEIS1 occupancy at CDK-inhibitor loci not fully resolved
    • How the same factor activates CDK inhibitors in heart yet drives proliferation elsewhere unexplained
  17. 2014 High

    Defined post-translational and competitive control of MEIS1 protein levels and uncovered new physical partners and a co-repressor function for nuclear receptor signaling.

    Evidence Pbx3 stabilization via ubiquitination/half-life assays and EMSA; PREP1 competition for PBX1 with DDX3X/DDX5 co-IP; MEIS1-AR co-IP/GST pull-down with PSA ChIP; C/EBPalpha co-occupancy ChIP-seq with KO

    PMID:24578510 PMID:24958854 PMID:25158280 PMID:25911551

    Open questions at the time
    • The E3 ligase ubiquitinating MEIS1 not identified in these studies
    • Functional role of DDX3X/DDX5 binding in transcription not detailed
  18. 2015 High

    Mapped genome-wide MEIS1 binding in developmental contexts, revealing HOX/PBX-independent target sites, mutually exclusive switching with NKX2-5 in heart, a Pax6-BMP-Atoh1 cerebellar cascade, and a direct HLF-oxidative stress axis in leukemia.

    Evidence ChIP-seq/RNA-seq in eye primordium; ChIP/EMSA competition with NKX2-5; conditional KO with BMP/Atoh1 readouts in cerebellum; HLF promoter ChIP with HLF and hypoxia rescue in MLL-AF9 cells

    PMID:25740828 PMID:26253404 PMID:26411676 PMID:29317485

    Open questions at the time
    • Determinants of context-specific HOX-independent binding undefined
    • How redox control integrates with self-renewal program incomplete
  19. 2016 High

    Identified a direct MEIS1 target driving leukemic homing and showed PBX3/MEIS1 alone is sufficient to transform hematopoietic cells without ectopic HOX.

    Evidence ChIP-seq and rescue defining MEIS1->SYTL1->CXCR4 trafficking pathway; retroviral PBX3/MEIS1 co-expression with interaction-disrupting mutants and AML transplantation

    PMID:26747896 PMID:27018596

    Open questions at the time
    • Source of HOX gene upregulation under PBX3/MEIS1 not fully resolved
    • Whether SYTL1 contributes outside leukemia unknown
  20. 2017 High

    Revealed a Syk-Meis1 feedback loop in HOXA9/Meis1 AML operating through PU.1 and miR-146a, providing a therapeutic vulnerability.

    Evidence Phosphoproteomics, PU.1 ChIP, miR-146a target validation, and in vivo Syk inhibition

    PMID:28399410

    Open questions at the time
    • Direct versus indirect steps of the loop not fully separated
    • Generalizability beyond HOXA9/Meis1 context untested
  21. 2018 Medium

    Extended post-translational regulation by linking BCAA metabolism via PPM1K to CDC20-dependent MEIS1/p21 ubiquitination, and detailed MEIS1's role in human pluripotent stem cell hematopoietic specification and RLS gene regulation.

    Evidence PPM1K KO mouse with MEIS1/p21 ubiquitination and CDC20 studies; hPSC differentiation targeting TAL1/FLI1; SKOR1 promoter ChIP/reporter with RLS SNP; PAF1c-SETDB1 H3K9me3 ChIP at Meis1/Hoxa9

    PMID:29358086 PMID:29719258 PMID:29774127 PMID:30111810

    Open questions at the time
    • Direct CDC20-MEIS1 enzymatic relationship requires further biochemical dissection
    • Single-lab studies for several mechanisms
  22. 2019 Medium

    Established MEIS1 as a regulator of cardiomyocyte metabolic identity, controlling the balance between glycolysis and oxidative phosphorylation.

    Evidence siRNA knockdown with Seahorse metabolic flux and MitoTracker in fetal cardiomyocytes

    PMID:30884246

    Open questions at the time
    • Direct metabolic-gene targets not identified
    • Single-lab study
  23. 2022 Medium

    Showed MEIS1 expression is epigenetically silenced by an EZH2-DNMT3a axis guided by lncRNA ELFN1-AS1, with downstream FEN1-mediated chemoresistance in colorectal cancer.

    Evidence ChIP at MEIS1 promoter, ELFN1-AS1 ASO knockdown, EZH2 inhibition, and in vivo tumor growth

    PMID:35351858

    Open questions at the time
    • Direct MEIS1 regulation of FEN1 versus indirect not fully separated
    • Single-lab study in one cancer type

Open questions

Synthesis pass · forward-looking unresolved questions
  • It remains unresolved how MEIS1 selects context-specific (HOX-dependent versus HOX-independent) genomic binding sites and how the same factor switches between promoting proliferation/self-renewal in stem and leukemic cells and enforcing cell-cycle arrest in cardiomyocytes.
  • No unified model linking partner choice to opposing cell-cycle outputs
  • Structural basis of context-dependent site selection unknown
  • Direct enzymatic mechanism of MEIS1 ubiquitination not reconstituted

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140110 transcription regulator activity 8 GO:0003677 DNA binding 6 GO:0140097 catalytic activity, acting on DNA 3
Localization
GO:0005634 nucleus 2 GO:0005654 nucleoplasm 1
Pathway
R-HSA-1266738 Developmental Biology 8 R-HSA-1643685 Disease 6 R-HSA-74160 Gene expression (Transcription) 6 R-HSA-1640170 Cell Cycle 4
Partners
ARDDX3XDDX5HOXA9NKX2-5PBX1PBX3PKNOX1
Complex memberships
HOX-PBX-MEIS1 trimeric complexMEIS1-PBX heterodimer

Evidence

Reading pass · 48 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1995 MEIS1 was identified as a novel homeobox gene (TALE family) activated by retroviral integration in 15% of BXH-2 myeloid leukemia tumors; its homeodomain is most closely related to PBX/exd family proteins, suggesting cooperative binding with HOX proteins. Retroviral insertion site cloning, Northern blot, cDNA cloning and sequence analysis Molecular and cellular biology Medium 7565694
1997 MEIS1 (AbdB-like HOX group 9-13) proteins physically interact with HOXA9 and other AbdB-like HOX proteins (HOXA10, HOXA11, HOXD12, HOXB13) by forming heterodimeric DNA binding complexes on a composite MEIS1 site (TGACAG) + AbdB-like HOX site (TTTTACGAC); HOX proteins dramatically stabilize MEIS1-DNA complexes (much slower dissociation), whereas HOX proteins from other paralog groups do not interact with MEIS1. Electrophoretic mobility shift assay (EMSA), in vitro DNA binding, heterodimer complex formation Molecular and cellular biology High 9343407
1997 MEIS1 and pKNOX1 dimerize with PBX1 on a TGATTGAC motif; the MEIS1/pKNOX1 interaction domain in PBX1 resides predominantly in a conserved N-terminal PBX domain that is deleted in the leukemic oncoprotein E2a-PBX1, and the Meis1-PBX interaction does not require the tryptophan residue N-terminal to the homeodomain (unlike HOX-PBX interactions), indicating a unique interaction mechanism. EMSA, DNA binding competition assay, domain mapping with deletion mutants, site-directed mutagenesis Proceedings of the National Academy of Sciences of the United States of America High 9405651
1998 MEIS1 and PBX1 cooperatively bind the cAMP-responsive sequence CRS1 from bovine CYP17, with purification of endogenous MEIS1-PBX1 complexes from adrenal cell nuclear extracts; the Meis1 N-terminal tryptophan is NOT required for this cooperative binding (unlike HOX-PBX), and the interaction is evolutionarily conserved with Drosophila exd and C. elegans ceh-20. CRS1 affinity chromatography purification, EMSA, site-directed mutagenesis, Western blot The Journal of biological chemistry High 9525891
1999 HOXA9, PBX2, and MEIS1 form trimeric complexes in myeloid leukemia cell nuclei: MEIS1 enhances in vitro HOXA9-PBX protein complex formation in the absence of DNA and forms a trimeric EMSA complex on a PBX-HOXA9 consensus site; co-immunoprecipitation of HOXA9 from myeloid cell extracts co-precipitates PBX2 and MEIS1; all three proteins are co-localized within nuclear speckles. EMSA, co-immunoprecipitation, in vitro DNA site selection, immunofluorescence co-localization Molecular and cellular biology High 10082572
1999 MEIS1 regulates proximal limb identity by promoting nuclear import of PBX1: Meis1 expression is restricted to proximal limb domains coinciding with nuclear PBX1 localization; ectopic Meis1 expression in chick and homothorax in Drosophila disrupts distal limb development and induces proximal-to-distal transformations. In situ hybridization, ectopic expression in chick embryos and Drosophila, immunolocalization of PBX1 nuclear translocation Nature High 10586884
1999 PBX-MEIS1/PREP1 complexes bind DNA cooperatively with myogenic bHLH heterodimers (E2a-MyoD, myogenin, Mrf-4, Myf-5) through a conserved tryptophan motif N-terminal to the bHLH DNA-binding domain; in vivo, MyoD requires this tryptophan motif to remodel chromatin at and activate the Myogenin promoter. EMSA cooperative binding assay, mutagenesis, in vivo chromatin remodeling assay, transfection reporter assay Nucleic acids research High 10471746
2001 MEIS1 genetically collaborates with both HOXA9 and HOXB3 (structurally divergent HOX genes) to generate acute myeloid leukemia; MEIS1 functions to accelerate leukemic onset while the HOX gene defines leukemia identity; PREP1 (despite sharing PBX nuclear retention activity with MEIS1) cannot substitute for MEIS1 in accelerating HOXA9-induced AML, indicating MEIS1 has transformation-specific functions beyond PBX nuclear localization. Retroviral bone marrow transduction/transplantation, genetic epistasis with PREP1 overexpression, in vivo leukemia latency assays Molecular and cellular biology High 11113197
2004 Meis1 is required in vivo for megakaryocyte production, definitive hematopoietic progenitor proliferation/self-renewal, vascular patterning (capillary formation), and normal eye development (lens and retina); Meis1-deficient embryos die by E14.5 with complete absence of megakaryocytes, hemorrhaging, and reduced colony-forming cells, and fail to radioprotect irradiated recipients. Meis1 knockout mouse generation, colony-forming assay, competitive repopulation, histology, radioprotection assay The EMBO journal High 14713950
2004 Enforced co-expression of HOXA9 and MEIS1 is sufficient to substitute for MLL-ENL fusion activity and immortalize hematopoietic cells; HOXA9+MEIS1 co-expression is required for continued proliferation and differentiation arrest in MLL-ENL-dependent cells. Inducible MLL-ENL-ERtm system, retroviral overexpression, 4-OHT withdrawal/differentiation assay, microarray Molecular and cellular biology High 14701735
2004 MEIS1 overexpression strongly induces caspase-dependent apoptosis in multiple cell types; this requires a functional homeodomain and PBX-interaction motif; co-expression of HOXA9 suppresses MEIS1-induced apoptosis and confers protection from apoptotic stimuli, whereas PBX1-induced apoptosis is not rescued by HOXA9. Retroviral overexpression, caspase inhibitor assays, apoptosis assays, domain deletion mutants Blood Medium 15479723
2005 Meis1 programs leukemic stem cell (cancer-initiating) potential in Hoxa9-immortalized myeloid progenitors; this requires PBX binding, DNA binding, and a conserved C-terminal domain function; Meis1 induces expression of FLT3 and CD34 (HSC-associated genes), and is the first example of a transcription factor oncoprotein (Meis1) establishing expression of a tyrosine kinase oncoprotein (FLT3). Retroviral overexpression, domain deletion mutagenesis, transplantation leukemia assay, gene expression analysis Blood High 15755900
2005 Meis1 is required for establishment of definitive hematopoiesis in the mouse embryo, including HSC specification in the AGM, formation of hematopoietic clusters in dorsal aorta/vitelline/umbilical arteries, and Runx1-expressing AGM mesenchymal cells; Meis1 mutants also show complete megakaryocyte lineage agenesis and vascular patterning defects. Meis1 gene inactivation in mice, fetal liver colony assay, immunohistochemistry, radioprotection assay Developmental biology High 15882575
2006 Meis1 leukemogenic activity requires co-occupancy of Meis1-Pbx and Hox-Pbx complexes on target gene promoters (including Flt3); a VP16-Meis1 fusion acts as an autonomous oncoprotein replacing both Meis1 C-terminal domain and Hoxa9 N-terminal domain functions, establishing that these domains cooperate in transcriptional activation of leukemia-associated target genes; ChIP confirmed co-occupancy of Hoxa9 and Meis1 on the Flt3 promoter. VP16/engrailed fusion proteins, retroviral overexpression, chromatin immunoprecipitation (ChIP), leukemia transplantation assay Molecular and cellular biology High 16648484
2006 Meis1 transforming activity requires three conserved domains: the Pbx interaction motif (PIM), the homeodomain, and the C-terminal region; PIM and homeodomain deletion mutants are individually non-functional but domain-swap complementation restores full oncogenic activity; VP16 transactivation domain can replace the C-terminal domain and induce spontaneous leukemia accompanied by endogenous Hoxa9/Hoxa7 activation, establishing that Hoxa gene activation is a key downstream event for Meis1 oncogenesis. Domain deletion/swap mutagenesis, retroviral bone marrow transplantation, gene expression analysis Blood High 16469876
2007 Meis1 is an essential and rate-limiting regulator of MLL leukemia stem cell (LSC) potential: Meis1 knockout/knockdown/dominant-negative abrogates MLL oncoprotein-induced AML; Meis1 quantitatively controls extent of self-renewal, differentiation arrest, cycling, and rate of in vivo LSC generation from myeloid progenitors; codependent on redundant contributions of Pbx2 and Pbx3. Conditional knockout, shRNA knockdown, dominant-negative genetic techniques, serial transplantation, LSC frequency analysis Genes & development High 17942707
2008 Meis1 leukemogenic activity with NUP98-HOXD13 requires the PBX-interaction domain, homeodomain, and C-terminal domain but not the N-terminal domain; the N-terminal domain is specifically required for Flt3 upregulation; ChIP revealed in vivo occupancy of MEIS1 on regulatory sequences of Trib2, Flt3, Dlk1, Ccl3, Ccl4, Pf4, and Rgs1; Trib2 overexpression complements ND13 to induce AML. Structure-function mutagenesis, retroviral bone marrow transplantation, ChIP, gene expression profiling Experimental hematology High 18375036
2008 meis1 acts as a positive cell cycle regulator in early zebrafish retinal progenitor cells by directly regulating cyclin D1 and c-myc transcription; meis1 morpholino knockdown causes G1-to-S phase transition delay and severely reduced eyes; forced maintenance of meis1 expression is incompatible with normal retinal differentiation. Morpholino knockdown in zebrafish, cell cycle analysis, gene expression analysis, mosaic expression assay Development (Cambridge, England) Medium 18216175
2008 In chick and mouse retina, Meis1 and Meis2 maintain retinal progenitor cells in a rapidly proliferating state; Meis-inactivating constructs impair RPC proliferation and cause microphthalmia; Meis protein knockdown reduces cyclin D1 (Ccnd1) expression in the eye primordium, and co-transfection of cyclin D1 partially rescues RPC proliferation. Transfection of dominant-negative Meis constructs, RNA interference, cyclin D1 rescue experiment, in chick and mouse Development (Cambridge, England) Medium 18216174
2008 MEIS1 directly regulates meis1 target gene Trib2, and Meis1 directly binds regulatory sequences of Trib1; Trib1 and Evi1 are key collaborators in Hoxa9/Meis1-induced AML (identified by retroviral insertional mutagenesis), with Trib1 acting as a novel myeloid oncogene that enhances ERK phosphorylation to inhibit apoptosis. Retroviral insertional mutagenesis screen, retroviral co-expression, AML transplantation assay Blood Medium 17227832
2008 miR-155 directly targets the 3'-UTR of MEIS1 mRNA, downregulating MEIS1 expression; enforced miR-155 expression impairs megakaryocytic differentiation and proliferation of hematopoietic progenitor cells, with MEIS1 identified as a functional target. 3'-UTR luciferase reporter assay, Western blot, overexpression of miR-155, MK differentiation assay British journal of haematology Medium 18950466
2009 HOXA9 indirectly regulates Meis1 expression through direct transcriptional activation of CREB1 and PKNOX1, whose protein products induce Meis1; HOXA9 does not directly bind Meis1 promoter/enhancer regions by ChIP analysis; forced CREB1 expression in Hoxa9-/- bone marrow increases Meis1 mRNA, establishing CREB1 as an intermediary in HOXA9-mediated Meis1 regulation. ChIP, quantitative RT-PCR, Hoxa9-/- mouse genetics, retroviral CREB1 overexpression, compound Meis1+/-/Hoxa9-/- mice Molecular and cellular biology High 19620287
2009 Ectopic Meis1 expression in the distal mouse limb bud causes proximal-to-distal patterning defects (proximal shift of limb identities and Hox gene expression domains); this P-D patterning function of Meis1 is independent of Pbx1, as Pbx1 deficiency does not modify the Msx2:Meis1 transgenic limb phenotype. Msx2:Meis1 transgenic mouse generation, in situ hybridization for Hox gene expression, genetic epistasis with Pbx1-/- mice The International journal of developmental biology Medium 19247936
2010 Meis1 and Pbx act upstream of gata1 in the zebrafish erythropoietic transcription factor hierarchy: Meis1/Pbx-depleted embryos show severe loss of gata1 expression, reduced embryonic hemoglobin, and increased pu.1-positive myeloid cells; gata1 overexpression rescues hemoglobin expression in Pbx/Meis1-depleted embryos, placing Meis1/Pbx upstream of gata1. Morpholino knockdown in zebrafish, genetic epistasis by gata1 mRNA rescue, in situ hybridization Developmental biology Medium 20123093
2010 Meis1 directly activates cyclin D3 transcription; M33-MEIS1 (transcriptional repressor form) impedes G1-to-S phase progression correlating with reduced cyclin D3 levels and inhibition of retinoblastoma (pRb) hyperphosphorylation; cyclin D3 overexpression partially rescues the G1 accumulation and growth suppression caused by M33-Meis1. Retroviral M33-MEIS1 expression, cell cycle analysis, Western blot for cyclin D3 and pRb, ChIP, cyclin D3 rescue experiments Blood High 20237320
2010 Meis1 directly binds an enhancer element 35 kb upstream of the Gfi1 gene in early hematopoietic cells (fetal liver and dorsal aorta), acting as an upstream regulator of Gfi1 transcription in hematopoietic stem cell emergence. Locus-wide ChIP, transgenic enhancer assay in mice Molecular and cellular biology Medium 20516218
2011 MEIS1 RNAi in C. elegans (MEIS1 orthologue) increases ferritin expression; the RLS-associated MEIS1 risk haplotype leads to increased expression of ferritin and DMT1 in RLS brain tissues; human cells under iron-deficient conditions show reduced MEIS1 expression, establishing a link between MEIS1 and iron homeostasis regulation. RNAi in C. elegans, gene expression analysis in human RLS brain tissue, iron deprivation experiment in human cells Annals of neurology Medium 21710629
2011 MN1-induced leukemogenesis requires the MEIS1/AbdB-like HOX protein complex: common myeloid progenitors (CMP) but not granulocyte-macrophage progenitors (GMP) are susceptible to MN1 transformation; MEIS1/AbdB-like HOX complementation of GMPs restores susceptibility; ChIP-seq identified common target genes of MN1 and MEIS1 with identical binding sites for a large proportion of chromatin targets. Progenitor-specific transformation assay, CMP vs GMP complementation, ChIP-seq, shRNA knockdown Cancer cell High 21741595
2012 Meis1 deletion leads to accumulation of reactive oxygen species (ROS) in HSCs, loss of quiescence, and decreased expression of hypoxia-response genes; ROS scavenging with N-acetyl cysteine or VHL knockdown (hypoxia pathway stabilization) reverses effects of Meis1 deletion on HSC maintenance, placing Meis1 in a pathway regulating oxidative metabolism in HSCs. Inducible Meis1 knockout mice, ROS measurement, colony formation assay, NAC rescue, VHL shRNA rescue, gene expression analysis Blood High 23091297
2013 Meis1 is a critical transcriptional regulator of cardiomyocyte cell cycle arrest: Meis1 deletion in mouse cardiomyocytes extends the postnatal proliferative window and re-activates cardiomyocyte mitosis in the adult heart; Meis1 overexpression decreases neonatal myocyte proliferation and inhibits neonatal heart regeneration; Meis1 is required for transcriptional activation of CDK inhibitors p15, p16, and p21. Cardiomyocyte-specific Meis1 conditional KO, Meis1 overexpression, BrdU/pH3 proliferation assays, cardiac injury/regeneration assay, qRT-PCR/Western blot for CDK inhibitors Nature High 23594737
2013 Gfi1b, together with co-factors LSD1 and CoREST, directly represses meis1 transcription in erythroid cells (but not megakaryocytes) by occupying distinct regions of the Meis1 promoter; Meis1 is substantially upregulated in gfi1b-/- fetal liver cells; SNAG-domain mutant or DNA-binding-deficient Gfi1b fails to repress the meis1 promoter reporter. ChIP, gene expression profiling of gfi1b-/- cells, LSD1 inhibitor treatment, promoter reporter transfection with mutagenesis PloS one High 23308270
2014 MEIS1 functions as a novel androgen receptor (AR) co-repressor: MEIS1 inhibits AR transcriptional activity and reduces AR target gene (PSA) expression; MEIS1-AR protein-protein interaction was demonstrated by co-immunoprecipitation and GST pull-down; MEIS1 modulates AR nuclear translocation and recruitment to the PSA promoter androgen response element; MEIS1 promotes recruitment of NCoR and SMRT co-repressors in the presence of androgen. Co-immunoprecipitation, GST pull-down, luciferase reporter assay, ChIP at PSA promoter, nuclear translocation assay Experimental cell research Medium 25158280
2014 Pbx3 stabilizes Meis1 protein by preventing its ubiquitination and proteasomal degradation: in the absence of Pbx3, Meis1 is highly unstable; deletion of the Pbx-binding domain on Meis1 or binding to Pbx3 prolongs Meis1 half-life; ubiquitin-proteasome inhibition blocks Meis1 degradation; Pbx3 overexpression also induces endogenous Meis1 transcription; Meis1/Pbx3 dimerization is required for high-affinity DNA/Hoxa9/Meis1/Pbx3 complex formation in vitro. Protein stability/half-life assays, ubiquitination assay, proteasome inhibitor treatment, domain deletion analysis, EMSA, retroviral overexpression, leukemia transplantation Haematologica High 25911551
2014 PREP1 competitively heterodimerizes with PBX1 against MEIS1: MEIS1 alone transforms PREP1-deficient fibroblasts; PREP1 overexpression inhibits MEIS1 tumorigenicity; PREP1 post-translationally decreases MEIS1 stability by sequestering PBX1; MEIS1 interaction with DDX3X and DDX5 is essential for MEIS1 tumorigenesis and is disrupted when PREP1 reduces MEIS1 levels. Transformation assay in MEFs, Western blot protein stability, co-immunoprecipitation for DDX3X/DDX5 interaction, overexpression competition assay Proceedings of the National Academy of Sciences of the United States of America Medium 24578510
2014 C/EBPα is a critical collaborator required for HOXA9/MEIS1-mediated leukemogenesis: loss of C/EBPα greatly improves survival in murine Hoxa9/Meis1 leukemia models; over 50% of Hoxa9 genome-wide binding sites are co-bound by C/EBPα; Hoxa9 represses the Cdkn2a/b locus in concert with C/EBPα to overcome G1 cell cycle arrest. ChIP-seq, conditional C/EBPα knockout, leukemia transplantation, cell proliferation assays Proceedings of the National Academy of Sciences of the United States of America High 24958854
2015 MEIS1 regulates Pax6 transcription in cerebellar granule cell precursors (GCPs) by binding an upstream Pax6 sequence; the Meis1-Pax6 cascade upregulates Smad protein expression to increase BMP signaling, which promotes Atoh1 degradation in the inner external granule layer, driving GCP differentiation; Meis1 conditional KO in GC lineage results in smaller cerebella with disorganized lobules and ectopic Atoh1-positive GCPs. Conditional Meis1 knockout in GC lineage, in vitro promoter binding assays, BMP signaling analysis (Smad phosphorylation), cerebellar slice culture with BMP inhibitors, knockdown experiments The Journal of neuroscience Medium 29317485
2015 During cardiac differentiation, MEIS1 and NKX2-5 bind overlapping sites in a mutually exclusive manner to regulate common target genes (exemplified by Popdc2); as cardiac progenitors differentiate, they sequentially experience high MEIS1 and then increasing NKX2-5, providing a spatial-temporal regulatory switch. ChIP, EMSA competitive binding assay, reporter assays, in situ hybridization during cardiac differentiation Cell reports Medium 26411676
2015 Meis1 loss leads to increased oxidative stress, oxygen flux, and apoptosis in MLL-AF9 leukemia cells; MEIS1 directly occupies the hepatic leukemia factor (HLF) promoter by ChIP; HLF expression (or hypoxia) reverses oxidative stress and rescues leukemia development in Meis1-deficient cells, establishing a Meis1-HLF-oxidative stress axis. Inducible Meis1-KO in MLL-AF9 knockin model, ChIP for HLF promoter, oxidative stress measurement, HLF overexpression rescue, hypoxia rescue Blood High 25740828
2015 In the eye primordium, Meis1 binds Hox/Pbx-independent chromatin sites (distinct from its trunk binding preference for Hox-Pbx sites); Meis1 haploinsufficiency causes microphthalmic traits by dose-dependently regulating retinal proliferation/differentiation genes and components of the Notch signaling pathway and eye territory-specific transcription factors. ChIP-seq, RNA-seq, conditional Meis1 loss-of-function and functional rescue, Meis1-/- embryo analysis Development (Cambridge, England) High 26253404
2016 PBX3 and MEIS1 co-expression (without ectopic HOX gene) is sufficient to transform normal hematopoietic stem/progenitor cells and cause AML in vivo; disruption of the MEIS1-PBX3 binding interaction abolishes cell transformation and HOX gene upregulation; PBX3/MEIS1 (but not HOXA9/MEIS1) recapitulates the MLL-fusion core transcriptome. Retroviral co-expression, murine AML transplantation, PBX3-MEIS1 interaction-disrupting mutations, gene expression profiling Cancer research High 26747896
2016 MEIS1 directly activates synaptotagmin-like 1 (SYTL1/Slp1) transcription (global MEIS1 ChIP-seq and gene expression in MEIS1-deficient cells); SYTL1 restores cell migration and engraftment in MEIS1-deficient leukemia cells; SYTL1 promotes CXCR4-dependent cell migration by controlling intracellular trafficking of CXCR4, revealing a MEIS1→SYTL1→CXCL12/CXCR4 pathway for leukemic homing. ChIP-seq, gene expression profiling of Meis1-deficient cells, SYTL1 rescue experiment, CXCR4 trafficking assay, in vivo homing/engraftment assay The Journal of clinical investigation High 27018596
2017 In Hoxa9/Meis1-driven AML, Meis1 increases Syk protein expression and activity through a feedback loop: Meis1 indirectly regulates miR-146a expression through transcription factor PU.1, and miR-146a directly targets Syk; in the context of Hoxa9, Syk signaling induces Meis1, creating a regulatory loop; Syk inhibition disrupts this loop and prolongs survival of mice with Hoxa9/Meis1 leukemia. Phosphoproteomics, Western blot, miR-146a target validation, PU.1 ChIP, Syk inhibitor treatment in vivo Cancer cell High 28399410
2018 PPM1K (a mitochondrial Ser/Thr phosphatase that promotes BCAA catabolism) maintains MEIS1 and p21 protein levels by decreasing their ubiquitination-mediated degradation controlled by the E3 ubiquitin ligase CDC20; PPM1K deficiency leads to decreased MEIS1/p21 signaling, reduced HSC glycolysis and quiescence. BCAA fluorescent sensor, PPM1K KO mouse, MEIS1/p21 ubiquitination assay, CDC20 interaction studies, leukemia model Cell reports Medium 29719258
2018 MEIS1 controls human pluripotent stem cell hematopoietic differentiation by targeting TAL1 (which mediates HEP specification) and FLI1 (which is required for megakaryopoiesis); MEIS1 is vital for specification of APLNR+ mesoderm progenitors to hemogenic endothelial progenitors. hPSC differentiation, MEIS1 overexpression/knockdown, downstream target identification (TAL1, FLI1), flow cytometry Stem cell reports Medium 29358086
2018 MEIS1 directly binds and positively regulates the SKOR1 promoter at two specific sites, and this regulation is modified by an RLS-associated SNP in the SKOR1 promoter region, establishing a direct molecular link between two RLS-associated genes. Luciferase reporter assay, ChIP, SNP-dependent promoter activity assay Scientific reports Medium 30111810
2018 PAF1c (through subunit CDC73) interacts with SETDB1 (H3K9 methyltransferase); stabilization of PAF1c-SETDB1 interaction reduces transcription of Meis1 and Hoxa9 by increasing H3K9me3 at their promoters in AML cells. Proteomics (CDC73 interactome), ChIP for H3K9me3 at Meis1/Hoxa9 promoters, AML cell growth assay Oncotarget Medium 29774127
2019 MEIS1 suppression by siRNA in fetal cardiomyocytes increases maximal oxygen consumption and mitochondrial activity while decreasing glycolytic gene expression, establishing MEIS1 as a regulator of the cardiomyocyte metabolic program (glycolysis vs. oxidative phosphorylation). siRNA knockdown, Seahorse metabolic flux analysis, MitoTracker staining, gene expression analysis FASEB journal Medium 30884246
2022 MEIS1 transcription is epigenetically suppressed by EZH2-DNMT3a recruited to the MEIS1 promoter with the aid of lncRNA ELFN1-AS1; MEIS1 suppression following this axis increases FEN1 expression, which mediates oxaliplatin resistance in colorectal cancer. ChIP for EZH2/DNMT3a at MEIS1 promoter, ELFN1-AS1 ASO knockdown, EZH2 inhibitor GSK126, FEN1 expression analysis, in vivo tumor growth Signal transduction and targeted therapy Medium 35351858

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2013 Meis1 regulates postnatal cardiomyocyte cell cycle arrest. Nature 465 23594737
2004 Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization. Molecular and cellular biology 273 14701735
1995 Meis1, a PBX1-related homeobox gene involved in myeloid leukemia in BXH-2 mice. Molecular and cellular biology 272 7565694
2001 Defining roles for HOX and MEIS1 genes in induction of acute myeloid leukemia. Molecular and cellular biology 248 11113197
2004 Hematopoietic, angiogenic and eye defects in Meis1 mutant animals. The EMBO journal 242 14713950
1999 Conserved regulation of proximodistal limb axis development by Meis1/Hth. Nature 236 10586884
2007 Meis1 is an essential and rate-limiting regulator of MLL leukemia stem cell potential. Genes & development 228 17942707
1997 AbdB-like Hox proteins stabilize DNA binding by the Meis1 homeodomain proteins. Molecular and cellular biology 226 9343407
2002 Differential expression of Hox, Meis1, and Pbx1 genes in primitive cells throughout murine hematopoietic ontogeny. Experimental hematology 225 11823037
1999 HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cells. Molecular and cellular biology 206 10082572
1999 Frequent co-expression of the HOXA9 and MEIS1 homeobox genes in human myeloid leukemias. Leukemia 190 10602420
2005 The homeodomain protein Meis1 is essential for definitive hematopoiesis and vascular patterning in the mouse embryo. Developmental biology 186 15882575
1997 Meis1 and pKnox1 bind DNA cooperatively with Pbx1 utilizing an interaction surface disrupted in oncoprotein E2a-Pbx1. Proceedings of the National Academy of Sciences of the United States of America 167 9405651
2022 Downregulation of MEIS1 mediated by ELFN1-AS1/EZH2/DNMT3a axis promotes tumorigenesis and oxaliplatin resistance in colorectal cancer. Signal transduction and targeted therapy 143 35351858
2001 Upregulation of Meis1 and HoxA9 in acute lymphocytic leukemias with the t(4 : 11) abnormality. Oncogene 140 11314021
2007 Trib1 and Evi1 cooperate with Hoxa and Meis1 in myeloid leukemogenesis. Blood 132 17227832
2012 miR-196b directly targets both HOXA9/MEIS1 oncogenes and FAS tumour suppressor in MLL-rearranged leukaemia. Nature communications 130 22353710
2002 Nup98-HoxA9 immortalizes myeloid progenitors, enforces expression of Hoxa9, Hoxa7 and Meis1, and alters cytokine-specific responses in a manner similar to that induced by retroviral co-expression of Hoxa9 and Meis1. Oncogene 102 12082612
2016 Deregulation of the HOXA9/MEIS1 axis in acute leukemia. Current opinion in hematology 100 27258906
2005 Meis1 programs transcription of FLT3 and cancer stem cell character, using a mechanism that requires interaction with Pbx and a novel function of the Meis1 C-terminus. Blood 98 15755900
1999 A conserved motif N-terminal to the DNA-binding domains of myogenic bHLH transcription factors mediates cooperative DNA binding with pbx-Meis1/Prep1. Nucleic acids research 97 10471746
2017 Hoxa9 and Meis1 Cooperatively Induce Addiction to Syk Signaling by Suppressing miR-146a in Acute Myeloid Leukemia. Cancer cell 95 28399410
2012 Meis1 preserves hematopoietic stem cells in mice by limiting oxidative stress. Blood 90 23091297
2008 A role for MEIS1 in MLL-fusion gene leukemia. Blood 84 19109563
2006 Persistent transactivation by meis1 replaces hox function in myeloid leukemogenesis models: evidence for co-occupancy of meis1-pbx and hox-pbx complexes on promoters of leukemia-associated genes. Molecular and cellular biology 81 16648484
2008 Evidence for an evolutionary conserved role of homothorax/Meis1/2 during vertebrate retina development. Development (Cambridge, England) 80 18216174
2008 MicroRNA 155 modulates megakaryopoiesis at progenitor and precursor level by targeting Ets-1 and Meis1 transcription factors. British journal of haematology 76 18950466
2011 Cell of origin in AML: susceptibility to MN1-induced transformation is regulated by the MEIS1/AbdB-like HOX protein complex. Cancer cell 74 21741595
2008 meis1 regulates cyclin D1 and c-myc expression, and controls the proliferation of the multipotent cells in the early developing zebrafish eye. Development (Cambridge, England) 74 18216175
2014 C/EBPα is an essential collaborator in Hoxa9/Meis1-mediated leukemogenesis. Proceedings of the National Academy of Sciences of the United States of America 70 24958854
2011 Restless legs syndrome-associated MEIS1 risk variant influences iron homeostasis. Annals of neurology 70 21710629
2002 Frequent co-expression of HoxA9 and Meis1 genes in infant acute lymphoblastic leukaemia with MLL rearrangement. British journal of haematology 67 12358913
2019 Super-enhancer-associated MEIS1 promotes transcriptional dysregulation in Ewing sarcoma in co-operation with EWS-FLI1. Nucleic acids research 64 30496486
2015 Pbx3 and Meis1 cooperate through multiple mechanisms to support Hox-induced murine leukemia. Haematologica 63 25911551
2018 MEIS1 and MEIS2 Expression and Prostate Cancer Progression: A Role For HOXB13 Binding Partners in Metastatic Disease. Clinical cancer research : an official journal of the American Association for Cancer Research 62 29716922
2018 PPM1K Regulates Hematopoiesis and Leukemogenesis through CDC20-Mediated Ubiquitination of MEIS1 and p21. Cell reports 60 29719258
2010 Gfi1 expression is controlled by five distinct regulatory regions spread over 100 kilobases, with Scl/Tal1, Gata2, PU.1, Erg, Meis1, and Runx1 acting as upstream regulators in early hematopoietic cells. Molecular and cellular biology 60 20516218
2001 The MEIS1 oncogene is highly expressed in neuroblastoma and amplified in cell line IMR32. Genomics 60 11161815
2016 PBX3 and MEIS1 Cooperate in Hematopoietic Cells to Drive Acute Myeloid Leukemias Characterized by a Core Transcriptome of the MLL-Rearranged Disease. Cancer research 57 26747896
2008 Linkage of Meis1 leukemogenic activity to multiple downstream effectors including Trib2 and Ccl3. Experimental hematology 56 18375036
2011 Down-regulation of homeobox genes MEIS1 and HOXA in MLL-rearranged acute leukemia impairs engraftment and reduces proliferation. Proceedings of the National Academy of Sciences of the United States of America 55 21518888
2017 A tale of TALE, PREP1, PBX1, and MEIS1: Interconnections and competition in cancer. BioEssays : news and reviews in molecular, cellular and developmental biology 53 28322463
2018 MEIS1 Regulates Hemogenic Endothelial Generation, Megakaryopoiesis, and Thrombopoiesis in Human Pluripotent Stem Cells by Targeting TAL1 and FLI1. Stem cell reports 51 29358086
2010 The Hox cofactors Meis1 and Pbx act upstream of gata1 to regulate primitive hematopoiesis. Developmental biology 50 20123093
1998 Members of the meis1 and pbx homeodomain protein families cooperatively bind a cAMP-responsive sequence (CRS1) from bovine CYP17. The Journal of biological chemistry 50 9525891
2015 IDH2 and NPM1 Mutations Cooperate to Activate Hoxa9/Meis1 and Hypoxia Pathways in Acute Myeloid Leukemia. Cancer research 49 25795706
2014 Prep1 and Meis1 competition for Pbx1 binding regulates protein stability and tumorigenesis. Proceedings of the National Academy of Sciences of the United States of America 48 24578510
2003 Homeodomain proteins MEIS1 and PBXs regulate the lineage-specific transcription of the platelet factor 4 gene. Blood 48 12609849
2015 Sequential Binding of MEIS1 and NKX2-5 on the Popdc2 Gene: A Mechanism for Spatiotemporal Regulation of Enhancers during Cardiogenesis. Cell reports 47 26411676
2018 Novel MEIS1-NCOA2 Gene Fusions Define a Distinct Primitive Spindle Cell Sarcoma of the Kidney. The American journal of surgical pathology 46 30179902
2021 Recurrent MEIS1-NCOA2/1 fusions in a subset of low-grade spindle cell sarcomas frequently involving the genitourinary and gynecologic tracts. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 45 33574497
2009 Ectopic Meis1 expression in the mouse limb bud alters P-D patterning in a Pbx1-independent manner. The International journal of developmental biology 43 19247936
1997 Identification of a conserved family of Meis1-related homeobox genes. Genome research 43 9049632
2015 Retinoic Acid Receptor β Controls Development of Striatonigral Projection Neurons through FGF-Dependent and Meis1-Dependent Mechanisms. The Journal of neuroscience : the official journal of the Society for Neuroscience 42 26511239
2018 Meis1 Coordinates Cerebellar Granule Cell Development by Regulating Pax6 Transcription, BMP Signaling and Atoh1 Degradation. The Journal of neuroscience : the official journal of the Society for Neuroscience 41 29317485
2000 The homeobox gene MEIS1 is amplified in IMR-32 and highly expressed in other neuroblastoma cell lines. European journal of cancer (Oxford, England : 1990) 41 11094311
2010 Meis1 specifies positional information in the retina and tectum to organize the zebrafish visual system. Neural development 40 20809932
2016 MEIS1-mediated transactivation of synaptotagmin-like 1 promotes CXCL12/CXCR4 signaling and leukemogenesis. The Journal of clinical investigation 39 27018596
2015 Meis1 coordinates a network of genes implicated in eye development and microphthalmia. Development (Cambridge, England) 38 26253404
2012 Dual actions of Meis1 inhibit erythroid progenitor development and sustain general hematopoietic cell proliferation. Blood 38 22665933
2006 Molecular dissection of Meis1 reveals 2 domains required for leukemia induction and a key role for Hoxa gene activation. Blood 38 16469876
2014 MiR-144 regulates hematopoiesis and vascular development by targeting meis1 during zebrafish development. The international journal of biochemistry & cell biology 37 24448023
2020 The emerging role of MEIS1 in cell proliferation and differentiation. American journal of physiology. Cell physiology 36 33296285
2018 Emerging Roles of Meis1 in Cardiac Regeneration, Stem Cells and Cancer. Current drug targets 36 28745213
2018 Sox9-Meis1 Inactivation Is Required for Adipogenesis, Advancing Pref-1+ to PDGFRα+ Cells. Cell reports 36 30355480
2009 HOXA9 modulates its oncogenic partner Meis1 to influence normal hematopoiesis. Molecular and cellular biology 36 19620287
2020 Entospletinib in Combination with Induction Chemotherapy in Previously Untreated Acute Myeloid Leukemia: Response and Predictive Significance of HOXA9 and MEIS1 Expression. Clinical cancer research : an official journal of the American Association for Cancer Research 35 32820015
2017 MEIS1 inhibits clear cell renal cell carcinoma cells proliferation and in vitro invasion or migration. BMC cancer 35 28270206
2013 Dynamic expression of MEIS1 homeoprotein in E14.5 forebrain and differentiated forebrain-derived neural stem cells. Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft 33 23756022
2019 Down-regulation of MEIS1 promotes the maturation of oxidative phosphorylation in perinatal cardiomyocytes. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 31 30884246
2015 Predicting the molecular role of MEIS1 in esophageal squamous cell carcinoma. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 31 26314854
2014 Meis1 regulates proliferation of non-small-cell lung cancer cells. Journal of thoracic disease 31 24977012
2010 The role of meis1 in primitive and definitive hematopoiesis during zebrafish development. Haematologica 31 21048033
2004 Meis1-mediated apoptosis is caspase dependent and can be suppressed by coexpression of HoxA9 in murine and human cell lines. Blood 31 15479723
2010 Linkage of the potent leukemogenic activity of Meis1 to cell-cycle entry and transcriptional regulation of cyclin D3. Blood 30 20237320
2019 MEIS1 and Restless Legs Syndrome: A Comprehensive Review. Frontiers in neurology 29 31551905
2011 MEIS1, PREP1, and PBX4 are differentially expressed in acute lymphoblastic leukemia: association of MEIS1 expression with higher proliferation and chemotherapy resistance. Journal of experimental & clinical cancer research : CR 29 22185299
2016 Correlation Between Meis1 and Msi1 in Esophageal Squamous Cell Carcinoma. Journal of gastrointestinal cancer 28 27142513
2015 MEIS1 regulates an HLF-oxidative stress axis in MLL-fusion gene leukemia. Blood 28 25740828
2011 A conserved tissue-specific homeodomain-less isoform of MEIS1 is downregulated in colorectal cancer. PloS one 28 21858198
2018 PAF1 complex interactions with SETDB1 mediate promoter H3K9 methylation and transcriptional repression of Hoxa9 and Meis1 in acute myeloid leukemia. Oncotarget 27 29774127
2017 Meis1: effects on motor phenotypes and the sensorimotor system in mice. Disease models & mechanisms 27 28645892
2014 MEIS1 regulates early erythroid and megakaryocytic cell fate. Haematologica 27 25107888
2021 The Small-Molecule Wnt Inhibitor ICG-001 Efficiently Inhibits Colorectal Cancer Stemness and Metastasis by Suppressing MEIS1 Expression. International journal of molecular sciences 26 34948208
2016 MicroRNAs regulating meis1 expression and inducing cardiomyocyte proliferation. Cardiovascular regenerative medicine 26 28111633
2014 Meis1 regulates epidermal stem cells and is required for skin tumorigenesis. PloS one 26 25013928
2013 Differential transcriptional regulation of meis1 by Gfi1b and its co-factors LSD1 and CoREST. PloS one 26 23308270
1997 Cloning and mapping of the MEIS1 gene, the human homolog of a murine leukemogenic gene. Genomics 25 9226379
2018 A direct interaction between two Restless Legs Syndrome predisposing genes: MEIS1 and SKOR1. Scientific reports 24 30111810
2014 MEIS1 functions as a potential AR negative regulator. Experimental cell research 24 25158280
2014 Nephroblastomas show low expression of microR-204 and high expression of its target, the oncogenic transcription factor MEIS1. Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society 23 24617557
2008 meis1 regulates the development of endothelial cells in zebrafish. Biochemical and biophysical research communications 22 18656453
2007 Flt3 is dispensable to the Hoxa9/Meis1 leukemogenic cooperation. Blood 22 17202314
2020 MEIS1 down-regulation by MYC mediates prostate cancer development through elevated HOXB13 expression and AR activity. Oncogene 21 32681068
2020 Transcription Factor ELF1 Activates MEIS1 Transcription and Then Regulates the GFI1/FBW7 Axis to Promote the Development of Glioma. Molecular therapy. Nucleic acids 21 33473327
2019 Role of MEIS1 in restless legs syndrome: From GWAS to functional studies in mice. Advances in pharmacology (San Diego, Calif.) 21 31229170
2018 Meis1 is specifically upregulated in kidney myofibroblasts during aging and injury but is not required for kidney homeostasis or fibrotic response. American journal of physiology. Renal physiology 21 29592525
2021 MEIS1 and its potential as a cancer therapeutic target (Review). International journal of molecular medicine 19 34318904
2019 Homeobox gene Meis1 modulates cardiovascular regeneration. Seminars in cell & developmental biology 19 31623926
2013 Zebrafish hoxd4a acts upstream of meis1.1 to direct vasculogenesis, angiogenesis and hematopoiesis. PloS one 19 23554940

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