Affinage

CREB1

Cyclic AMP-responsive element-binding protein 1 · UniProt P16220

Round 2 corrected
Length
327 aa
Mass
35.1 kDa
Annotated
2026-04-28
130 papers in source corpus 38 papers cited in narrative 38 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

CREB1 is a ubiquitously expressed bZIP transcription factor that integrates cAMP, growth factor, PI3K/Akt, and stress-activated signaling pathways to regulate genes controlling metabolism, cell survival, neuronal plasticity, immune function, and differentiation. Phosphorylation of Ser-133 by multiple kinases—PKA, RSK2, MSK1/2, Akt, MAPKAP-K2, CDK5, and S6K1—creates a binding surface for the KIX domain of the co-activators CBP/p300, with the phosphorylated kinase-inducible domain undergoing a coupled folding transition upon KIX engagement (PMID:9413984, PMID:8413673); a second co-activation input is provided by TORC/CRTC family members whose nuclear entry is gated by calcineurin-dependent dephosphorylation and release from 14-3-3 sequestration (PMID:15454081). CREB1 occupies approximately 4,000 promoter sites genome-wide, yet transcriptional induction occurs at only a subset, determined by selective CBP recruitment, CRE methylation status, and competition with NF-κB for limiting CBP/p300 (PMID:15753290, PMID:16007092). CREB1 protein abundance is itself regulated by Cullin-5-mediated ubiquitin-dependent degradation and by METTL3-catalyzed m6A modification of its mRNA, which controls transcript stability in immune cells (PMID:36662868, PMID:37267102).

Mechanistic history

Synthesis pass · year-by-year structured walk · 13 steps
  1. 1988 High

    Establishing CREB1's identity as a CRE-binding transcription factor resolved how cAMP-responsive promoters are read: cloning revealed a bZIP architecture with a basic DNA-binding region, leucine zipper dimerization motif, and an acidic transactivation domain that binds the palindromic TGACGTCA element.

    Evidence cDNA library screening with CRE probe, sequence analysis, domain mapping

    PMID:2974179

    Open questions at the time
    • No kinase or phosphorylation mechanism yet identified
    • No co-activator mechanism known
    • Dimerization partners undefined
  2. 1993 High

    Identifying CBP as the phospho-Ser-133-dependent co-activator solved how CREB1 phosphorylation is transduced into transcriptional output: PKA-phosphorylated CREB1 recruits CBP, and p300 was subsequently shown to function as a CBP homolog in this role.

    Evidence Biochemical co-precipitation of phospho-CREB1 with CBP; fusion-protein transcription assay; anti-CBP antibody microinjection; p300 substitution experiments

    PMID:7870179 PMID:8028671 PMID:8413673

    Open questions at the time
    • Structural basis of phospho-CREB1–KIX interaction unresolved
    • Mechanism selecting which of ~4,000 sites recruit CBP unknown
  3. 1997 High

    The NMR structure of the pKID–KIX complex revealed the molecular logic of signal-dependent co-activator recruitment: pKID is intrinsically disordered and folds into two α-helices only upon KIX binding, with the phosphoserine hydrogen-bonding to KIX Tyr-658.

    Evidence NMR solution structure of pKID–KIX complex

    PMID:9413984

    Open questions at the time
    • Full-length CREB1–CBP complex structure unavailable
    • Dynamics of coupled folding in chromatin context unknown
  4. 1998 High

    Demonstration that RSK2 (RAS-MAPK pathway), MAPKAP-K2 (p38 stress pathway), Akt (PI3K pathway), and MSK1 (dual ERK/p38 pathway) all phosphorylate CREB1 at Ser-133 established CREB1 as a signaling convergence node rather than a cAMP-exclusive effector.

    Evidence In vitro kinase assays with purified kinases; pharmacological inhibitors (LY294002, PD98059, SB203580); dominant-negative constructs; nuclear localization analysis of MSK1

    PMID:8688081 PMID:8887554 PMID:9687510 PMID:9829964

    Open questions at the time
    • Relative contribution of each kinase in specific tissues unresolved
    • Kinase-selective co-factor recruitment not yet addressed
  5. 2002 High

    MSK1/MSK2 double-knockout fibroblasts showed these kinases are genetically required for stress-induced (but not fully for mitogen-induced) CREB1 phosphorylation and immediate-early gene transcription, establishing pathway-specific kinase requirements in vivo.

    Evidence MSK1/MSK2 single and double KO mouse fibroblasts; phospho-CREB1 immunoblot; c-fos/junB RT-PCR

    PMID:11909979

    Open questions at the time
    • Compensatory kinases for mitogen-induced phosphorylation not identified
    • In vivo tissue-specific phenotypes not fully explored
  6. 2004 High

    The discovery of TORC2/CRTC2 as a phosphorylation-independent, calcium/cAMP-gated co-activator introduced a coincidence-detection mechanism: SIK-mediated phosphorylation sequesters CRTC2 in the cytoplasm via 14-3-3 binding, and simultaneous calcineurin activation plus SIK inhibition is needed for nuclear entry and CREB1 co-activation.

    Evidence TORC2–SIK2–14-3-3 co-IP; calcineurin/calcium manipulation; nuclear translocation imaging; CREB1 reporter assays

    PMID:15454081

    Open questions at the time
    • Whether all ~4,000 occupied sites require CRTC co-activation unknown
    • CRTC isoform specificity across tissues incompletely mapped
  7. 2005 High

    Genome-wide ChIP revealed that CREB1 occupies ~4,000 promoters but only a minority are transcriptionally induced by cAMP, demonstrating that occupancy alone is insufficient and that selective CBP recruitment and CRE methylation act as additional gating mechanisms; concurrently, competition between CREB1 and NF-κB for CBP was shown to determine cytokine output in immune cells.

    Evidence ChIP-on-chip with phospho-CREB1 profiling; microarray; CRE methylation analysis; GSK3 inhibitor in monocytes with CBP binding assays; in vivo LPS model

    PMID:15753290 PMID:16007092

    Open questions at the time
    • Chromatin accessibility determinants of selective activation not resolved
    • Quantitative model of CREB1–NF-κB–CBP competition lacking
  8. 2010 High

    Identification of CCDC6 as a CREB1-interacting repressor that recruits HDAC1 and PP1 to CRE sites explained how CREB1 target genes can be kept silent: loss of CCDC6 (as in RET/PTC1 rearrangements) derepresses CREB1 targets including AREG and cyclin A.

    Evidence Reciprocal co-IP of CCDC6–CREB1; ChIP for HDAC1/PP1 at CREB1 targets; reporter assays; PTC tissue IHC

    PMID:20498639

    Open questions at the time
    • Genome-wide extent of CCDC6-mediated repression unknown
    • Other co-repressor complexes at CRE sites not systematically cataloged
  9. 2011 High

    Temporal siRNA knockdown in Aplysia neurons showed that sustained CREB1 synthesis within a ~10-hour consolidation window is required for long-term synaptic facilitation, linking CREB1 protein turnover dynamics to memory consolidation.

    Evidence siRNA injection at defined post-5-HT timepoints in sensorimotor cocultures; electrophysiological LTF/LTE measurement

    PMID:21543617

    Open questions at the time
    • Mammalian in vivo consolidation-window studies for CREB1 turnover incomplete
    • Mechanisms controlling CREB1 translational kinetics in neurons not defined
  10. 2018 Medium

    CDK5 was identified as a non-canonical CREB1 kinase in glioma stem cells, extending the kinase repertoire beyond classical cAMP/MAPK pathways and linking aberrant CREB1 activation to brain tumor self-renewal; separately, CREB1–ERα co-binding at shared chromatin sites in breast cancer established CREB1 as a hormone receptor co-regulator.

    Evidence Drosophila suppressor screen identifying dCdk5; CDK5 inhibitor in GSCs; xenograft; CREB1–ERα co-IP and ChIP-seq overlap; phospho-null mutagenesis

    PMID:29742423 PMID:30456355

    Open questions at the time
    • CDK5-CREB1 axis not confirmed in non-glioma contexts
    • ERα-CREB1 interdependence mechanism not structurally resolved
  11. 2021 Medium

    Multiple studies converged to show that CREB1 activity is shaped by its own protein-level regulation: CREB1 CRISPR KO in CRC cells demonstrated that loss of CREB1 frees CBP/p300 for NF-κB capture, and CREB1 was shown to drive immune cell recruitment to vaccine sites via STING-dependent phosphorylation, broadening its role to innate immune signaling.

    Evidence CREB1 CRISPR KO with 45-pathway reporter; CBP co-IP; RNA-seq; NHP immunization transcriptomics; cGAMP/STING modulation of p-CREB1

    PMID:34556879 PMID:35696016

    Open questions at the time
    • Relative contribution of CREB1 vs other CRE-binding factors to CBP sequestration in different tissues unknown
    • STING-CREB1 link not validated in human vaccine recipients
  12. 2023 Medium

    Cullin-5 was identified as the E3 ligase mediating CREB1 ubiquitylation and degradation, establishing a proteostatic control mechanism; concurrently, METTL3-dependent m6A modification of Creb1 mRNA was shown to regulate its stability and protein output in iNKT cells, revealing an epitranscriptomic layer of CREB1 regulation.

    Evidence Transposon + CRISPR screens identifying Cullin-5; ubiquitylation assay; Mettl3 conditional KO; MeRIP-seq; Creb1 mRNA half-life measurement; Creb1 OE rescue of Mettl3-deficient iNKT phenotype

    PMID:36662868 PMID:37267102

    Open questions at the time
    • Cullin-5 recognition motif on CREB1 not mapped
    • Whether m6A regulation of CREB1 mRNA operates outside immune cells unknown
    • No structural model of Cullin-5–CREB1 interaction
  13. 2024 Medium

    Recent work extended CREB1's downstream target repertoire to include immune evasion (HLA-E transcription in myeloma), EMT (ZEB1 via Akt/mTOR/S6K1), and neuroendocrine differentiation (EZH2-mediated REST repression under androgen deprivation), solidifying CREB1 as a context-dependent transcriptional hub whose output depends on co-factor availability and upstream pathway identity.

    Evidence ChIP at HLA-E promoter with NK cytotoxicity assays; HTR2B/Akt/S6K1 inhibitor series with ChIP at ZEB1 promoter; EZH2 ChIP at REST locus with ADT xenograft

    PMID:38381131 PMID:38777812 PMID:38902472

    Open questions at the time
    • Systematic catalog of tissue-specific CREB1 target gene programs incomplete
    • Structural basis of kinase-selective co-factor recruitment unresolved
    • Therapeutic window for CREB1 inhibition in cancer not established

Open questions

Synthesis pass · forward-looking unresolved questions
  • A central unresolved question is how the same Ser-133 phosphorylation event, shared across >7 kinases, produces pathway-specific transcriptional outputs at distinct genomic loci—whether through kinase-specific co-factor recruitment, chromatin context, or combinatorial co-activator/co-repressor availability.
  • No single-molecule or kinase-tethered ChIP study has distinguished kinase-specific CREB1 target gene selection
  • Full interactome of CREB1 co-repressors beyond CCDC6 not systematically mapped
  • In vivo kinase-to-target gene wiring diagrams absent for most tissues

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140110 transcription regulator activity 8 GO:0003677 DNA binding 4
Localization
GO:0005634 nucleus 4 GO:0005654 nucleoplasm 2
Pathway
R-HSA-162582 Signal Transduction 8 R-HSA-74160 Gene expression (Transcription) 7 R-HSA-1643685 Disease 6 R-HSA-168256 Immune System 4 R-HSA-4839726 Chromatin organization 2 R-HSA-112316 Neuronal System 1
Partners
CCDC6CREBBPCRTC2CUL5EP300ESR1FOXA1MECP2

Evidence

Reading pass · 38 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1988 CREB1 was cloned from a placental cDNA library and shown to encode a 326-amino-acid protein with a C-terminal basic region adjacent to a leucine zipper motif responsible for DNA binding, and an N-terminal acidic transcriptional activation domain; it binds the palindromic CRE consensus sequence TGACGTCA. cDNA cloning, CRE-probe library screening, sequence analysis Science High 2974179
1990 The human CREB1 gene was mapped to chromosomal region 2q32.3–q34 by Southern blot analysis of mouse-human somatic cell hybrids and in situ hybridization. Somatic cell hybrid panel Southern blotting; in situ hybridization Genomics High 2142119
1993 PKA-phosphorylated CREB1 (at Ser-133) specifically binds the nuclear co-activator CBP (CREB-binding protein, 265 kDa); fusion of a heterologous DNA-binding domain to CBP confers PKA-regulated transcriptional activation, establishing CBP as a phospho-CREB1-dependent co-activator. Biochemical co-precipitation, fusion-protein transcriptional activation assay Nature High 8413673
1994 CBP is necessary for cAMP-regulated transcription via CREB1 in fibroblasts and also cooperates with c-Jun for mitogen-responsive transcription, indicating that CBP is a shared co-activator recruited by phosphorylated transcription factors including CREB1. Microinjection of anti-CBP antiserum; co-transfection assays Nature High 8028671
1995 p300, the adenoviral E1A-associated protein, is a functional homolog of CBP: it binds PKA-phosphorylated CREB1 with similar affinity and can substitute for CBP in potentiating CREB1-activated gene expression; E1A represses CREB1-dependent co-activator functions of both CBP and p300. Binding affinity assays, co-transfection reporter assays, E1A competition Nature High 7870179
1996 Growth factor (RAS-MAPK pathway) activates CREB1 by phosphorylating Ser-133 through RSK2 (pp90RSK family); RSK2 was purified, sequenced, and shown to mediate growth factor-induced CREB1 Ser-133 phosphorylation both in vitro and in vivo. RSK2 purification and sequencing; in vitro kinase assay; in vivo phosphorylation; dominant-negative RSK experiments Science High 8688081
1996 MAPKAP kinase-2, acting downstream of p38 MAP kinase, phosphorylates CREB1 at Ser-133 in response to FGF and cellular stress (UV, osmotic), identifying a stress/growth-factor pathway to CREB1 activation distinct from PKA. In vitro kinase assay with MAPKAP-K2; dominant-negative Ras; p38 inhibitor SB 203580; Gal4-CREB reporter transfection The EMBO Journal High 8887554
1997 NMR solution structure of the phosphorylated kinase-inducible domain (pKID) of CREB1 bound to the KIX domain of CBP revealed that pKID undergoes a coil-to-helix transition upon binding, forming two α-helices (αA and αB); αB occupies a hydrophobic groove on KIX defined by helices α1 and α3, and the phosphoserine hydrogen bonds to Tyr-658 of KIX. NMR structure determination of pKID-KIX complex Cell High 9413984
1998 Akt/PKB phosphorylates CREB1 at Ser-133 in response to serum/growth factors, promoting CBP recruitment and CREB1-dependent target gene expression; this effect requires PI3K activity (blocked by LY 294002) and is phospho-Ser-133-dependent. Overexpression of Akt in serum-stimulated cells; PI3K inhibitor LY 294002; reporter assays; phospho-Ser-133 mutagenesis The Journal of Biological Chemistry High 9829964
1998 MSK1 is directly activated by MAPK/ERK2 and SAPK2/p38 in vitro, localizes constitutively in the nucleus, and phosphorylates CREB1 at Ser-133 with a Km far lower than PKA, RSK, or MAPKAP-K2, identifying MSK1 as a key nuclear CREB1 kinase linking both growth factor and stress MAPK cascades. In vitro kinase assays; MSK1 nuclear localization (subcellular fractionation); pharmacological inhibitors (PD 98059, SB 203580); endogenous CREB1 phosphorylation in multiple cell lines The EMBO Journal High 9687510
2002 MSK1 and MSK2 are required for stress-induced (but not fully for mitogen-induced) phosphorylation of CREB1 and ATF1 at Ser-133 in primary fibroblasts, and for stress-induced transcription of c-fos and junB downstream of CREB1. MSK1/MSK2 single and double knockout mouse fibroblasts; phospho-CREB1 immunoblot; immediate-early gene RT-PCR Molecular and Cellular Biology High 11909979
2004 TORC2 (CREB-regulated transcription coactivator 2) functions as a calcium- and cAMP-sensitive coincidence detector for CREB1 activation: under resting conditions TORC2 is sequestered in the cytoplasm via phosphorylation-dependent 14-3-3 binding; glucose/gut hormones activate calcineurin and inhibit SIK2 kinase, cooperatively dephosphorylating TORC2 and promoting its nuclear entry and coactivation of CREB1. Calcineurin/SIK2 co-immunoprecipitation with TORC2; 14-3-3 interaction assay; nuclear translocation imaging; CREB1-reporter assays; calcium chelation and cAMP elevation Cell High 15454081
2005 Genome-wide ChIP analysis in human tissues revealed that CREB1 occupies ~4,000 promoter sites in vivo depending on CRE sequence and methylation state; cAMP agonist induces CREB1 Ser-133 phosphorylation at most occupied sites, but only a minority of target genes is transcriptionally induced, with selective CBP co-recruitment required for activation. Genome-wide ChIP-on-chip; phospho-CREB1 profiling; gene expression microarray; CRE methylation analysis Proceedings of the National Academy of Sciences of the United States of America High 15753290
2005 GSK3 differentially regulates TLR-mediated cytokine production downstream of CREB1: GSK3 inhibition shifts the balance between NF-κB p65 and CREB1 competing for CBP at the coactivator, reducing pro-inflammatory cytokines and increasing IL-10. GSK3 inhibitor treatment of monocytes/PBMCs; nuclear NF-κB and CREB1 CBP-binding assays; cytokine ELISA; in vivo LPS mouse model Nature Immunology High 16007092
2008 The CREB1 coactivator CRTC1 is required for energy balance and fertility: leptin dephosphorylates and activates nuclear CRTC1 in the hypothalamus; dephosphorylated CRTC1 stimulates Cartpt and Kiss1 gene expression via the CREB1-CRTC1 complex; dominant-negative CREB1 blocks leptin's induction of these neuropeptides. Crtc1 knockout mice (hyperphagic/obese/infertile phenotype); leptin administration; ChIP for CRTC1 at Cartpt/Kiss1 promoters; dominant-negative CREB1 blockade; CRTC1 OE/KD in hypothalamic cells Nature Medicine High 18758446
2010 CCDC6 interacts with CREB1 and represses its transcriptional activity by recruiting HDAC1 and protein phosphatase 1 to CRE sites of CREB1 target genes; loss of CCDC6 (as in RET/PTC1 thyroid carcinoma) leads to increased CREB1 phosphorylation and upregulation of CREB1 targets AREG and cyclin A. Co-immunoprecipitation of CCDC6 with CREB1; ChIP showing HDAC1 and PP1 recruitment; reporter assay; immunohistochemistry of PTC samples Oncogene High 20498639
2011 In Aplysia, sustained CREB1 synthesis (not just initial induction) is required for consolidation of long-term facilitation (LTF) and long-term excitability (LTE) of sensory neurons: siRNA knockdown of CREB1 at 0 or 10 h post-5-HT treatment blocked LTF, while knockdown at 16 h did not, defining a consolidation window dependent on newly synthesized CREB1. siRNA injection into Aplysia sensorimotor cocultures at defined times post-5-HT; electrophysiological measurement of LTF and LTE The Journal of Neuroscience High 21543617
2011 A TSH-CREB1-microRNA loop is required for thyroid cell growth: TSH activates CREB1, which represses a set of five miRNAs (including miR-1, miR-28-A) that would otherwise inhibit growth; three of these miRNAs target CREB1 itself, forming a positive-feedback loop between TSH, CREB1, and miRNA suppression. CREB1 ChIP at miRNA regulatory regions; miRNA overexpression growth assays; luciferase target validation Molecular Endocrinology Medium 21816899
2013 MTOR positively regulates CREB1 activity in cells; loss of TSC2 or PTEN (hyperactive MTOR) leads to CREB1 hyperactivation; impaired autophagy in these cells prevents autophagic suppression of CREB1, and CREB1 drives DNA damage and apoptosis in response to etoposide; rapamycin-mediated MTOR inhibition reduces CREB1 activity and chemosensitivity. TSC2/PTEN KO MEFs; Creb1 siRNA; rapamycin treatment; etoposide DNA damage assay; autophagy flux analysis; CREB1 activity in kidney tumor tissue and PTEN liver KO mice Autophagy Medium 24189100
2013 CREB1 forms a complex with Mecp2 at methylated CpG sites of the neuronal Glut3 gene promoter; sequential ChIP and co-IP showed that Creb1 recruits Mecp2 to the methylated CpG island, converting epigenetic repression into transcriptional activation of Glut3 during postnatal brain development. Chromatin IP; sequential ChIP; co-IP; luciferase reporter with methylated DNA; siRNA knockdown of Creb1 and Mecp2 in HT22 neurons; 5-aza-dC demethylation Endocrinology Medium 23493374
2015 CREB1 binds the promoter of miR-320a and activates its transcription during serum starvation; CREB1-driven miR-320a expression downregulates VDAC1 to facilitate mitophagy in cervical cancer cells. miR-320a promoter cloning and luciferase reporter; CREB1 ChIP at miR-320a promoter; CREB1 KD; VDAC1 protein levels by western blot Oncotarget Medium 26472185
2016 CREB1 and FoxA1 co-localize genome-wide and mutually influence each other's chromatin binding in prostate cancer cells; CREB1 drives pro-survival, cell cycle and metabolic transcription programs in both androgen-dependent and castration-resistant prostate cancer, and this co-regulatory activity is sensitive to MED1 co-regulatory inhibition. CREB1 and FoxA1 ChIP-seq; gene expression profiling; integrative genomics in cell lines and primary tissues/CTCs Nucleic Acids Research Medium 26743006
2018 CDK5, activated aberrantly in GBM, phosphorylates and activates CREB1 independently of the canonical PKA/cAMP pathway in glioma stem cells (GSCs); CDK5 inhibition prevents GSC self-renewal in vitro and in xenografts by suppressing CREB1 activation. Drosophila genetic suppressor screen (dCdk5); CDK5 inhibitor treatment of GSCs; xenograft assay; CREB1 phosphorylation western blot; TCGA analysis Cell Reports Medium 29742423
2018 CREB1 physically interacts with ERα and stimulates ERα transcriptional activity; phospho-CREB1 and ERα share hundreds of chromatin binding sites and are biochemically associated; CREB1's stimulatory activity requires its own DNA binding and Ser-133 phosphorylation, and CREB1 affects ERα chromatin recruitment. Co-IP (CREB1-ERα); ChIP-seq for CREB1 and ERα overlap; reporter assays with CREB1 phospho-null mutant; endogenous target gene analysis Life Science Alliance Medium 30456355
2020 Imperatorin directly binds CREB1 protein, inhibiting its phosphorylation and nuclear translocation, thereby blocking CREB1's interaction with the TGFβ2 gene promoter, repressing TGFβ2 expression and downstream ERK-mediated cancer invasion. Direct binding assay (compound-CREB1 interaction); CREB1 phosphorylation and nuclear translocation assays; ChIP of CREB1 at TGFβ2 promoter; multiple mouse metastasis models Advanced Science Medium 32832354
2020 DNA methylation of the CRE motif in the human BDNF promoter IV dramatically reduces CREB1 binding affinity (quantified by AlphaScreen assay), providing a direct quantitative measure of how CpG methylation impairs CREB1–promoter interaction. AlphaScreen proximity assay with purified CREB1 and methylated/unmethylated oligonucleotides Journal of Neuroscience Methods Medium 32416472
2021 Abiraterone acetate (AA) increases intracellular cAMP, activates kinases that phosphorylate CREB1 at Ser-133 (pCREB1), and upregulated pCREB1 enhances the CBP/p300 co-activator complex, leading to global gene expression changes underlying AA resistance in prostate cancer; blocking CREB1 phosphorylation re-sensitizes resistant cells to AA. AA-resistant cell line establishment; phospho-kinase array; RNA-seq; pCREB1 immunoblot; CREB1 phosphorylation inhibition; CBP/p300 inhibitor sensitivity assay Clinical Cancer Research Medium 33495313
2021 CREB1 is specifically active in prostate luminal cells and transcriptionally induces ING4 and its E3 ligase JFK during luminal differentiation; oncogenic PTEN loss leads to constitutive CREB1 activation, which suppresses ING4, disrupting luminal cell differentiation; CREB1 blockade in tumor cells rescues ING4 expression and restores (then kills) luminal cells. RNA-seq; CREB1 inhibitor (666-15); PTEN KO model; ING4/JFK promoter analysis; IHC of primary prostate tumors; in vivo xenograft Oncogene Medium 33846571
2021 CREB1 induction by the ALVAC + Alum HIV vaccine vector drives expression of cytokine/chemokine target genes and recruits CD4+ T cells and B cells to antigen presentation sites via direct cGAMP/STING-modulated p-CREB1 activity; CREB1 target gene expression predicted reduced HIV acquisition in the RV144 trial. NHP immunization with ALVAC+Alum vs ALVAC+MF59; transcriptomic analysis; CREB1 target gene expression; cGAMP (STING agonist) modulation of p-CREB1 Nature Immunology Medium 34556879
2021 CREB1 is knocked out by CRISPR in CRC cells and triggers EMT with enhanced motility but reduced proliferation; mechanistically, CREB1 loss reduces MYC expression by impairing transcription of lncRNA CCAT1; simultaneously, loss of CREB1 frees CBP/p300 to be captured by NF-κB p65, activating the NF-κB pathway and inducing EMT. CREB1 CRISPR KO in HCT116; 45-pathway reporter panel; RNA-seq; CREB1 ChIP at CCAT1; CBP/p300 co-IP with CREB1 vs p65 Science China Life Sciences Medium 35696016
2022 Ebola virus VP35 binds human AKIP1, which activates PKA and downstream CREB1; activated CREB1 is recruited into viral ribonucleoprotein complexes in inclusion bodies and is required for EBOV replication; additionally, VP35-dependent CREB1 activation upregulates coagulation-related genes (THBD, SERPINB2) potentially contributing to hemorrhage. VP35-AKIP1 co-IP; PKA activation assay; CREB1 recruitment to VIBs by imaging; AKIP1 KD and PKA/CREB1 inhibition reducing EBOV replication; ChIP for CREB1 at coagulation gene promoters Nature Communications Medium 35474062
2023 Cullin-5 ubiquitylates and degrades CREB1 (especially under protein damage conditions); Cullin-5 deficiency leads to CREB1 accumulation, CREB1-driven CCL2 secretion, and accumulation of immunosuppressive myeloid cells in the tumor microenvironment, accelerating Brca1-deficient breast tumorigenesis; CREB1 inhibition reverses these tumor microenvironment changes. Sleeping beauty transposon screen + CRISPR genome-wide screen identifying Cullin-5; CREB1 ubiquitylation/degradation assay; CREB1 KO and inhibitor treatment; immune cell flow cytometry in TME; in vivo tumor models Science Advances Medium 36662868
2023 CREB1 transcriptionally activates stearoyl-CoA desaturase (SCD) by binding to SCD's promoter; SCD converts saturated to monounsaturated fatty acids, reducing polyunsaturated fatty acid availability for lipid peroxidation, thereby conferring ferroptosis resistance in NSCLC; PKA inhibition reduces pCREB1, sensitizing cells to ferroptosis inducers. High-throughput ChIP screening; ChIP-qPCR and dual-luciferase validation of CREB1 at SCD promoter; CREB1 KD xenograft with ferroptosis inducer IKE; SCD rescue experiments; lipid peroxidation assays Respiratory Research Medium 37957645
2023 CREB1 promotes CXCR4 expression in neutrophils; TNF and CXCL12 activate CREB1 in neutrophils via de novo synthesis, and CREB1-dependent CXCR4 upregulation generates a CXCR4hi neutrophil subset with enhanced NETosis, pro-inflammatory cytokine production, and glycolytic activity that amplifies skin inflammation in psoriasis. CREB1 KD in neutrophils; ChIP for CREB1 at CXCR4 promoter; CXCR4hi vs CXCR4lo neutrophil functional comparisons (NETs, phagocytosis, cytokines, metabolism); in vivo psoriasis mouse model with CXCR4/CXCL12 blockade Nature Communications Medium 37736772
2023 Mettl3-mediated m6A modification of the Creb1 transcript controls its stability and protein levels in iNKT cells; conditional Mettl3 ablation reduces Creb1 mRNA stability and protein/phosphorylation levels, impairing iNKT cell proliferation, differentiation, and cytokine secretion; ectopic Creb1 expression rescues Mettl3-deficient iNKT developmental defects. Mettl3 conditional KO in DP thymocytes; Creb1 conditional KO in DP thymocytes; MeRIP-seq; Creb1 mRNA stability assay; iNKT cell phenotyping; Creb1 OE rescue Cell Reports Medium 37267102
2024 CREB1 directly binds the HLA-E promoter and drives HLA-E transcription in multiple myeloma cells even in the presence of IFN-γ; CREB1 inhibition reduces HLA-E surface expression and restores NK cell-mediated cytotoxicity against myeloma. ChIP for CREB1 at HLA-E promoter; genomic and pharmacological CREB1 inhibition (666-15); HLA-E flow cytometry; NK cell co-culture cytotoxicity assays with patient samples Leukemia Medium 38902472
2024 HTR2B (5-HT receptor) signaling activates CREB1 phosphorylation at Ser-133 via the Akt/mTOR/S6K1 pathway; phospho-CREB1 translocates to the nucleus and directly binds the CREB1 half-site (GTCA) in the ZEB1 promoter to activate ZEB1 transcription, promoting EMT and metastasis in colorectal cancer. HTR2B pharmacological blockade and knockdown; Akt/mTOR/S6K1 inhibitors; CREB1 Ser-133 phosphorylation western blot; nuclear translocation imaging; ChIP for pCREB1 at ZEB1 promoter; in vivo metastasis mouse models Molecular Cancer Research Medium 38381131
2024 Androgen deprivation activates CREB1 signaling, which represses REST expression through EZH2-mediated epigenetic silencing of the REST locus; genetic rescue experiments showed that ADT-induced neuroendocrine differentiation requires both EZH2 repression of REST and CREB1 pathway activation. REST OE/KD in PCa cells and xenografts; CREB1 inhibition; EZH2 inhibition; ChIP for EZH2 at REST locus; neuroendocrine marker expression; ADT mouse xenograft model Cell Death Discovery Medium 38777812

Source papers

Stage 0 corpus · 130 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1993 Phosphorylated CREB binds specifically to the nuclear protein CBP. Nature 1795 8413673
2005 A human protein-protein interaction network: a resource for annotating the proteome. Cell 1704 16169070
2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America 1479 12477932
2009 A census of human transcription factors: function, expression and evolution. Nature reviews. Genetics 1191 19274049
2015 The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell 1118 26186194
2017 Architecture of the human interactome defines protein communities and disease networks. Nature 1085 28514442
1996 Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase. Science (New York, N.Y.) 1074 8688081
2005 Toll-like receptor-mediated cytokine production is differentially regulated by glycogen synthase kinase 3. Nature immunology 938 16007092
2017 Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science (New York, N.Y.) 934 28473536
2020 A reference map of the human binary protein interactome. Nature 849 32296183
1998 Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB. The EMBO journal 842 9687510
1998 CREB is a regulatory target for the protein kinase Akt/PKB. The Journal of biological chemistry 829 9829964
2005 Genome-wide analysis of cAMP-response element binding protein occupancy, phosphorylation, and target gene activation in human tissues. Proceedings of the National Academy of Sciences of the United States of America 816 15753290
2003 Complete sequencing and characterization of 21,243 full-length human cDNAs. Nature genetics 754 14702039
2021 Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Cell 705 33961781
1988 Cyclic AMP-responsive DNA-binding protein: structure based on a cloned placental cDNA. Science (New York, N.Y.) 699 2974179
1994 Activation of cAMP and mitogen responsive genes relies on a common nuclear factor. Nature 694 8028671
2012 A census of human soluble protein complexes. Cell 689 22939629
2010 The role of the transcription factor CREB in immune function. Journal of immunology (Baltimore, Md. : 1950) 664 21084670
2011 Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Briefings in bioinformatics 656 21873635
1997 Solution structure of the KIX domain of CBP bound to the transactivation domain of CREB: a model for activator:coactivator interactions. Cell 648 9413984
2001 Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase. The EMBO journal 641 11500364
2010 An atlas of combinatorial transcriptional regulation in mouse and man. Cell 573 20211142
1996 FGF and stress regulate CREB and ATF-1 via a pathway involving p38 MAP kinase and MAPKAP kinase-2. The EMBO journal 569 8887554
1995 Adenoviral E1A-associated protein p300 as a functional homologue of the transcriptional co-activator CBP. Nature 553 7870179
2004 The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector. Cell 549 15454081
2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome research 438 15489334
2010 CREB: a multifaceted regulator of neuronal plasticity and protection. Journal of neurochemistry 431 21044077
2015 Panorama of ancient metazoan macromolecular complexes. Nature 407 26344197
2002 MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblasts. Molecular and cellular biology 374 11909979
2007 EWSR1-CREB1 is the predominant gene fusion in angiomatoid fibrous histiocytoma. Genes, chromosomes & cancer 209 17724745
2012 Tumors with EWSR1-CREB1 and EWSR1-ATF1 fusions: the current status. The American journal of surgical pathology 192 22510762
2008 The Creb1 coactivator Crtc1 is required for energy balance and fertility. Nature medicine 167 18758446
2007 EWSR1-CREB1 and EWSR1-ATF1 fusion genes in angiomatoid fibrous histiocytoma. Clinical cancer research : an official journal of the American Association for Cancer Research 167 18094413
2011 The CREB1-BDNF-NTRK2 pathway in depression: multiple gene-cognition-environment interactions. Biological psychiatry 131 21215389
2022 CircEZH2/miR-133b/IGF2BP2 aggravates colorectal cancer progression via enhancing the stability of m6A-modified CREB1 mRNA. Molecular cancer 127 35773744
2021 Regorafenib enhances antitumor immunity via inhibition of p38 kinase/Creb1/Klf4 axis in tumor-associated macrophages. Journal for immunotherapy of cancer 119 33753566
2016 Downregulation of microRNA-27b-3p enhances tamoxifen resistance in breast cancer by increasing NR5A2 and CREB1 expression. Cell death & disease 94 27809310
2016 The microRNA miR-124 suppresses seizure activity and regulates CREB1 activity. Expert reviews in molecular medicine 67 26996991
2022 Saffron essential oil ameliorates CUMS-induced depression-like behavior in mice via the MAPK-CREB1-BDNF signaling pathway. Journal of ethnopharmacology 61 36126781
2023 CREB1-driven CXCR4hi neutrophils promote skin inflammation in mouse models and human patients. Nature communications 58 37736772
2018 UCA1 promotes cell proliferation and invasion of gastric cancer by targeting CREB1 sponging to miR-590-3p. Cancer medicine 53 29516678
2015 MiR-1224-5p acts as a tumor suppressor by targeting CREB1 in malignant gliomas. Molecular and cellular biochemistry 52 25648114
2023 Chronic stress promotes colorectal cancer progression by enhancing glycolysis through β2-AR/CREB1 signal pathway. International journal of biological sciences 50 37151872
2020 Direct Targeting of CREB1 with Imperatorin Inhibits TGFβ2-ERK Signaling to Suppress Esophageal Cancer Metastasis. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 48 32832354
2017 The cAMP responsive element-binding (CREB)-1 gene increases risk of major psychiatric disorders. Molecular psychiatry 47 29158582
2013 MicroRNA-200b targets CREB1 and suppresses cell growth in human malignant glioma. Molecular and cellular biochemistry 47 23543137
2020 Knockdown of miR-124 Reduces Depression-like Behavior by Targeting CREB1 and BDNF. Current neurovascular research 46 32189593
2017 Luteolin inhibits colorectal cancer cell epithelial-to-mesenchymal transition by suppressing CREB1 expression revealed by comparative proteomics study. Journal of proteomics 46 28391045
2013 MTOR inhibition attenuates DNA damage and apoptosis through autophagy-mediated suppression of CREB1. Autophagy 44 24189100
2011 The requirement for enhanced CREB1 expression in consolidation of long-term synaptic facilitation and long-term excitability in sensory neurons of Aplysia. The Journal of neuroscience : the official journal of the Society for Neuroscience 44 21543617
2019 CREB1 induced lncRNA HAS2-AS1 promotes epithelial ovarian cancer proliferation and invasion via the miR-466/RUNX2 axis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 40 31082772
2016 MiR-582-5p/miR-590-5p targeted CREB1/CREB5-NF-κB signaling and caused opioid-induced immunosuppression in human monocytes. Translational psychiatry 40 26978739
2016 Understanding the CREB1-miRNA feedback loop in human malignancies. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 40 27059735
2015 CREB1-driven expression of miR-320a promotes mitophagy by down-regulating VDAC1 expression during serum starvation in cervical cancer cells. Oncotarget 39 26472185
2022 CREB1 contributes colorectal cancer cell plasticity by regulating lncRNA CCAT1 and NF-κB pathways. Science China. Life sciences 38 35696016
2010 CCDC6 represses CREB1 activity by recruiting histone deacetylase 1 and protein phosphatase 1. Oncogene 38 20498639
2020 Intracranial myxoid mesenchymal tumor with EWSR1-CREB1 gene fusion: a case report and literature review. Brain tumor pathology 37 32215804
2018 A CREB1/miR-433 reciprocal feedback loop modulates proliferation and metastasis in colorectal cancer. Aging 37 30523220
2019 The HBx-CTTN interaction promotes cell proliferation and migration of hepatocellular carcinoma via CREB1. Cell death & disease 36 31138777
2018 CDK5 Inhibition Resolves PKA/cAMP-Independent Activation of CREB1 Signaling in Glioma Stem Cells. Cell reports 35 29742423
2017 MicroRNA-122 inhibits proliferation and invasion in gastric cancer by targeting CREB1. American journal of cancer research 34 28337380
2017 Knockdown of CREB1 inhibits tumor growth of human gastric cancer in vitro and in vivo. Oncology reports 34 28498439
1990 Assignment of the human gene for CREB1 to chromosome 2q32.3-q34. Genomics 34 2142119
2020 circ_0136666 Facilitates the Progression of Colorectal Cancer via miR-383/CREB1 Axis. Cancer management and research 33 32821160
2020 Antagonistic effect of VDR/CREB1 pathway on cadmium-induced apoptosis in porcine spleen. Ecotoxicology and environmental safety 32 33360786
2018 Knockdown of CREB1 promotes apoptosis and decreases estradiol synthesis in mouse granulosa cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 32 30021350
2016 Integrative analysis identifies targetable CREB1/FoxA1 transcriptional co-regulation as a predictor of prostate cancer recurrence. Nucleic acids research 32 26743006
2021 Abiraterone Acetate Induces CREB1 Phosphorylation and Enhances the Function of the CBP-p300 Complex, Leading to Resistance in Prostate Cancer Cells. Clinical cancer research : an official journal of the American Association for Cancer Research 31 33495313
2019 GATA6 suppresses migration and metastasis by regulating the miR-520b/CREB1 axis in gastric cancer. Cell death & disease 31 30674866
2011 A TSH-CREB1-microRNA loop is required for thyroid cell growth. Molecular endocrinology (Baltimore, Md.) 31 21816899
2018 Clear Cell Odontogenic Carcinoma: Occurrence of EWSR1-CREB1 as Alternative Fusion Gene to EWSR1-ATF1. Head and neck pathology 29 30047065
2020 Circular RNA hsa_circ_0075828 promotes bladder cancer cell proliferation through activation of CREB1. BMB reports 27 31072448
2021 Hepatitis B Virus DNA Polymerase Restrains Viral Replication Through the CREB1/HOXA Distal Transcript Antisense RNA Homeobox A13 Axis. Hepatology (Baltimore, Md.) 26 32314410
2017 CREB1 regulates glucose transport of glioma cell line U87 by targeting GLUT1. Molecular and cellular biochemistry 26 28646353
2021 lncRNA MALAT1 Regulates Mouse Granulosa Cell Apoptosis and 17β-Estradiol Synthesis via Regulating miR-205/CREB1 Axis. BioMed research international 25 33681369
2020 LncRNA MALAT1 inhibits apoptosis of endometrial stromal cells through miR-126-5p-CREB1 axis by activating PI3K-AKT pathway. Molecular and cellular biochemistry 25 32809092
2020 IGF2-AS knockdown inhibits glycolysis and accelerates apoptosis of gastric cancer cells through targeting miR-195/CREB1 axis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 25 34321174
2023 Inhibition of PKA/CREB1 pathway confers sensitivity to ferroptosis in non-small cell lung cancer. Respiratory research 24 37957645
2018 CREB1, a direct target of miR-122, promotes cell proliferation and invasion in bladder cancer. Oncology letters 24 30127997
2020 Combining Bioinformatics and Experiments to Identify CREB1 as a Key Regulator in Senescent Granulosa Cells. Diagnostics (Basel, Switzerland) 22 32403258
2017 GNB3 and CREB1 gene polymorphisms combined with negative life events increase susceptibility to major depression in a Chinese Han population. PloS one 22 28225778
2010 Epistatic interaction of CREB1 and KCNJ6 on rumination and negative emotionality. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 22 20943350
2021 The transcription factor CREB1 is a mechanistic driver of immunogenicity and reduced HIV-1 acquisition following ALVAC vaccination. Nature immunology 21 34556879
2021 Systematical analysis reveals a strong cancer relevance of CREB1-regulated genes. Cancer cell international 21 34641874
2020 Primary pulmonary myxoid sarcoma with EWSR1-CREB1 fusion: a case report and review of the literature. Diagnostic pathology 21 32039736
2018 Effects of CREB1 gene silencing on cognitive dysfunction by mediating PKA-CREB signaling pathway in mice with vascular dementia. Molecular medicine (Cambridge, Mass.) 21 30134805
2024 Serotonin Receptor HTR2B Facilitates Colorectal Cancer Metastasis via CREB1-ZEB1 Axis-Mediated Epithelial-Mesenchymal Transition. Molecular cancer research : MCR 20 38381131
2022 CREB1 promotes proliferation and differentiation by mediating the transcription of CCNA2 and MYOG in bovine myoblasts. International journal of biological macromolecules 19 35777504
2018 SP1, MYC, CTNNB1, CREB1, JUN genes as potential therapy targets for neuropathic pain of brain. Journal of cellular physiology 19 30478830
2017 CREB1 and Smad3 mediate TGF‑β3‑induced Smad7 expression in rat hepatic stellate cells. Molecular medicine reports 18 28983617
2020 Silencing SGK1 alleviates osteoarthritis through epigenetic regulation of CREB1 and ABCA1 expression. Life sciences 17 33171176
2019 Overexpression of microRNA‑101 causes anti‑tumor effects by targeting CREB1 in colon cancer. Molecular medicine reports 17 30816471
2015 MicroRNA-506 inhibits esophageal cancer cell proliferation via targeting CREB1. International journal of clinical and experimental pathology 17 26617801
2022 Ebola virus VP35 hijacks the PKA-CREB1 pathway for replication and pathogenesis by AKIP1 association. Nature communications 16 35474062
2007 Clenbuterol inhibits SREBP-1c expression by activating CREB1. Journal of biochemistry and molecular biology 16 17669268
2024 Forskolin-driven conversion of human somatic cells into induced neurons through regulation of the cAMP-CREB1-JNK signaling. Theranostics 15 38389831
2022 miR-125b-5p upregulation by TRIM28 induces cisplatin resistance in non-small cell lung cancer through CREB1 inhibition. BMC pulmonary medicine 15 36476351
2021 Long coding RNA CCAT2 enhances the proliferation and epithelial-mesenchymal transition of cervical carcinoma cells via the microRNA-493-5p/CREB1 axis. Bioengineered 15 34499007
2020 A new methodological approach for in vitro determination of the role of DNA methylation on transcription factor binding using AlphaScreen® analysis: Focus on CREB1 binding at hBDNF promoter IV. Journal of neuroscience methods 15 32416472
2020 Wnt2bb Induces Cardiomyocyte Proliferation in Zebrafish Hearts via the jnk1/c-jun/creb1 Pathway. Frontiers in cell and developmental biology 15 32523947
2019 miR-133a-3p promotes apoptosis and induces cell cycle arrest by targeting CREB1 in retinoblastoma. Archives of medical science : AMS 15 32542098
2012 Metastatic angiomatoid fibrous histiocytoma of the scalp, with EWSR1-CREB1 gene fusions in primary tumor and nodal metastasis. Human pathology 15 23199525
2011 CREB1 and CREB-binding protein in striatal medium spiny neurons regulate behavioural responses to psychostimulants. Psychopharmacology 15 21766169
2024 CREB1 promotes expression of immune checkpoint HLA-E leading to immune escape in multiple myeloma. Leukemia 14 38902472
2021 Aberrant CREB1 activation in prostate cancer disrupts normal prostate luminal cell differentiation. Oncogene 14 33846571
2020 EZH2 inhibition promotes ANGPTL4/CREB1 to suppress the progression of ulcerative colitis. Life sciences 14 32194081
2020 miR-134-5p inhibition reduces infarct-induced cardiomyocyte apoptosis via Creb1 upregulation. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 14 32689640
2013 Creb1-Mecp2-(m)CpG complex transactivates postnatal murine neuronal glucose transporter isoform 3 expression. Endocrinology 14 23493374
2024 The CREB1 inhibitor 666-15 maintains cartilage homeostasis and mitigates osteoarthritis progression. Bone & joint research 13 38163445
2024 Cardiopulmonary progenitors facilitate cardiac repair via exosomal transfer of miR-27b-3p targeting the SIK1-CREB1 axis. Cell proliferation 13 38185757
2023 Mettl3-m6A-Creb1 forms an intrinsic regulatory axis in maintaining iNKT cell pool and functional differentiation. Cell reports 13 37267102
2021 Long noncoding RNA XIST modulates microRNA-135/CREB1 axis to influence osteogenic differentiation of osteoblast-like cells in mice with tibial fracture healing. Human cell 13 34635983
2020 cAMP Response Element Binding Protein 1 (CREB1) Promotes Monounsaturated Fatty Acid Synthesis and Triacylglycerol Accumulation in Goat Mammary Epithelial Cells. Animals : an open access journal from MDPI 13 33066354
2019 MiR-155-5p affects Wilms' tumor cell proliferation and apoptosis via targeting CREB1. European review for medical and pharmacological sciences 13 30779069
2018 MicroRNA-205 affects mouse granulosa cell apoptosis and estradiol synthesis by targeting CREB1. Journal of cellular biochemistry 13 30556190
2009 CREB1/ATF1 activation in photoreceptor degeneration and protection. Investigative ophthalmology & visual science 13 19643965
2023 Cullin-5 deficiency orchestrates the tumor microenvironment to promote mammary tumor development through CREB1-CCL2 signaling. Science advances 12 36662868
2022 MiR-654-3p Constrains Proliferation, Invasion, and Migration of Sinonasal Squamous Cell Carcinoma via CREB1/PSEN1 Regulatory Axis. Frontiers in genetics 12 35096015
2022 STAT3 regulates SRGN and promotes metastasis of nasopharyngeal carcinoma through the FoxO1-miR-148a-5p-CREB1 axis. Laboratory investigation; a journal of technical methods and pathology 12 35562411
2021 Tumor necrosis factor-α induces claudin-3 upregulation in kidney tubular epithelial cells through NF-κB and CREB1. American journal of physiology. Cell physiology 12 33439776
2020 TGF‑β1 induces CREB1‑mediated miR‑1290 upregulation to antagonize lung fibrosis via Napsin A. International journal of molecular medicine 12 32319530
2018 ERα activity depends on interaction and target site corecruitment with phosphorylated CREB1. Life science alliance 12 30456355
2017 A CREB1 Gene Polymorphism (rs2253206) Is Associated with Prospective Memory in a Healthy Cohort. Frontiers in behavioral neuroscience 12 28559802
2024 Androgen deprivation induces neuroendocrine phenotypes in prostate cancer cells through CREB1/EZH2-mediated downregulation of REST. Cell death discovery 11 38777812
2024 Baicalein upregulates macrophage TREM2 expression via TrKB-CREB1 pathway to attenuate acute inflammatory injury in acute-on-chronic liver failure. International immunopharmacology 11 39047449
2023 The SIK1/CRTC2/CREB1 and TWIST1/PI3K/Akt/GSK3β signaling pathways mediated by microRNA-25-3p are altered in the schizophrenic rat brain. Frontiers in cellular neuroscience 11 36744005
2023 LncRNA TDRKH-AS1 promotes breast cancer progression via the miR-134-5p/CREB1 axis. Journal of translational medicine 11 38008726
2021 An insertion/deletion within the CREB1 gene identified using the RNA-sequencing is associated with sheep body morphometric traits. Gene 11 33484760
2019 Differential Regulation of Innate and Learned Behavior by Creb1/Crh-1 in Caenorhabditis elegans. The Journal of neuroscience : the official journal of the Society for Neuroscience 11 31413073