Affinage

HOOK2

Protein Hook homolog 2 · UniProt Q96ED9

Length
719 aa
Mass
83.2 kDa
Annotated
2026-06-10
45 papers in source corpus 15 papers cited in narrative 15 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 5/5 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

HOOK2 is a centrosomal adaptor protein that organizes microtubule-based architecture and links specific cargoes to the cytoplasmic dynein-dynactin retrograde transport machinery (PMID:17140400, PMID:34882091). It localizes to the centrosome throughout the cell cycle via its C-terminal domain, which directly binds centriolin/CEP110, and loss of HOOK2 function abolishes radial microtubule organization and regrowth after depolymerization (PMID:17140400); it acts at the centrosome downstream of CENP-F, whose Hook2-binding domain alone is sufficient to drive centrosome-specific microtubule nucleation (PMID:19793914). As a subunit of the ~500-kDa FTS-Hook-FHIP (FHF) complex, HOOK2 forms homo- and heterodimers with other Hook paralogs and couples organelles to dynein-dynactin: in combination with FHIP2A it confers specificity for Rab1A-positive ER-to-Golgi cargo and moves processively with dynein and dynactin in single-molecule reconstitutions, while the complex also binds the AP-4 μ4 subunit to position AP-4/ATG9A cargo perinuclearly (PMID:18799622, PMID:32073997, PMID:34882091). HOOK2 regulates a limiting step in primary ciliogenesis by stabilizing PCM1 and complexing with Rab8a, the overexpression of which rescues the HOOK2-depletion ciliary defect (PMID:21998199), and it recruits the PAR6α/aPKC/PAR3 polarity machinery to the centrosome to drive Golgi reorientation during directed cell migration (PMID:27624926). It further promotes pericentrosomal aggresome formation by facilitating microtubule-based delivery of misfolded protein aggregates (PMID:17540036), and is selectively incorporated into Hook2-dynein-Nde1-Lis1 complexes that are engaged by Pin1 upon mitotic CDK1 phosphorylation of the dynein LIC1 C-terminus (PMID:34709360).

Mechanistic history

Synthesis pass · year-by-year structured walk · 15 steps
  1. 2006 High

    Established HOOK2's foundational identity as a constitutive centrosomal protein required for radial microtubule organization, answering where it acts and through which binding partner.

    Evidence Direct binding assay of the Hook2 C-terminal domain to centriolin/CEP110, cell-cycle immunofluorescence, and dominant-negative microtubule-regrowth phenotypes

    PMID:17140400

    Open questions at the time
    • Did not define how centriolin recruitment relates to dynein cargo transport
    • No structural basis for the C-terminal/centriolin interaction
  2. 2007 Medium

    Showed HOOK2 contributes to aggresome biogenesis, extending its centrosomal role to microtubule-based delivery of protein aggregates.

    Evidence Overexpression and C-terminal-deletion dominant-negative Hook2 with a CFTR aggresome formation assay

    PMID:17540036

    Open questions at the time
    • Mechanism linking Hook2 to motor-driven aggregate transport not resolved
    • Whether endogenous Hook2 is rate-limiting for aggresome formation untested
  3. 2008 High

    Placed HOOK2 within the conserved FTS-Hook-FHIP multiprotein complex, reframing it from a standalone centrosomal protein to a trafficking adaptor.

    Evidence Mass spectrometry of purified FTS complexes, yeast two-hybrid, co-immunoprecipitation, and siRNA with endosomal trafficking readout in HEK293T cells

    PMID:18799622

    Open questions at the time
    • Did not assign cargo specificity to the Hook2-containing complex versus other paralogs
    • Direct motor coupling not yet demonstrated
  4. 2009 High

    Identified CENP-F as a centrosomal partner acting through HOOK2, demonstrating HOOK2 transmits an upstream signal for centrosome-specific microtubule nucleation.

    Evidence Yeast two-hybrid, co-immunoprecipitation, CENP-F knockout microtubule repolymerization assay, and a Hook2-binding truncation rescue

    PMID:19793914

    Open questions at the time
    • Molecular events downstream of the CENP-F/Hook2 interaction unresolved
    • Golgi-derived microtubule nucleation independent of this pathway
  5. 2009 Medium

    Demonstrated paralog-selective binding of MSUT-2 to HOOK2, indicating distinct partner repertoires among the three Hook proteins.

    Evidence Yeast two-hybrid and in vitro protein binding assays comparing HOOK1/2/3

    PMID:19273536

    Open questions at the time
    • No functional consequence of the MSUT-2/HOOK2 interaction tested
    • Cellular context of the interaction unknown
  6. 2011 High

    Defined HOOK2 as a regulator of a limiting step in primary ciliogenesis via PCM1 stabilization and Rab8a complex formation.

    Evidence siRNA depletion with ciliogenesis readout, co-immunoprecipitation with PCM1 and GFP::Rab8a, and Rab8a overexpression rescue in retinal epithelial cells

    PMID:21998199

    Open questions at the time
    • How Hook2 mechanistically stabilizes PCM1 not defined
    • Connection between ciliary role and FHF dynein coupling unexplored
  7. 2015 Medium

    Linked HOOK2 to manchette microtubule organization in spermatogenesis through direct binding of LRGUK-1.

    Evidence Yeast two-hybrid, co-immunoprecipitation/co-localization, GUK-like domain mapping, and LRGUK-1 knockout mouse phenotype

    PMID:25781171

    Open questions at the time
    • Functional attribution to HOOK2 specifically is indirect
    • Whether HOOK2 loss alone replicates the manchette defect untested
  8. 2016 Medium

    Expanded the manchette model to a defined LRGUK1-Hook-RIMBP3-KLC3 complex, situating HOOK2 in germ-cell microtubule dynamics.

    Evidence Yeast two-hybrid, GUK-like domain mapping, biochemical validation, and co-localization in haploid male germ cells

    PMID:28003339

    Open questions at the time
    • Specific contribution of HOOK2 versus HOOK1/HOOK3 not separated
    • Stoichiometry and assembly order of the complex unknown
  9. 2016 Medium

    Showed HOOK2 recruits the PAR6α/aPKC polarity complex to the centrosome to drive Golgi reorientation during directed migration, connecting it to cell polarity.

    Evidence Reciprocal co-immunoprecipitation, domain mapping, siRNA with Golgi-reorientation/PAR6α localization readout, and overexpression aggresome recruitment

    PMID:27624926

    Open questions at the time
    • Whether dynein transport mediates PAR6α recruitment not tested
    • Single-lab phenotype lacking independent replication
  10. 2019 Medium

    Established HOOK2 as a general recruiter of multiple proteins to the centrosome during cytokinesis.

    Evidence Immunofluorescence and siRNA knockdown with LSR/tricellulin/PAR3 centrosome localization readout during cytokinesis

    PMID:31662022

    Open questions at the time
    • Mechanism of multi-protein recruitment unresolved
    • Functional consequence for cytokinesis completion not defined
  11. 2020 High

    Demonstrated direct coupling of the FHF complex to the AP-4 adaptor via Hook coiled-coil domains, mechanistically linking HOOK2 to retrograde transport of AP-4/ATG9A cargo.

    Evidence Affinity purification-mass spectrometry, direct binding of AP-4 μ4 to Hook coiled-coil domains, and siRNA with AP-4/ATG9A localization readout

    PMID:32073997

    Open questions at the time
    • Whether HOOK2 versus HOOK1 dominates AP-4 binding in vivo not separated
    • Dynein motor engagement inferred rather than reconstituted here
  12. 2021 High

    Resolved cargo specificity by showing FTS-FHIP2A-Hook2 complexes select Rab1A ER-to-Golgi cargo and move processively with dynein-dynactin, distinct from Hook1/Hook3 endosomal complexes.

    Evidence FHIP interactome proteomics, live-cell imaging, single-molecule in vitro reconstitution with dynein/dynactin, and FHIP2A siRNA Rab1A tubule motility readout

    PMID:34882091

    Open questions at the time
    • Structural basis of combinatorial FHIP/Hook cargo selection unresolved
    • Regulation of switching between cargo-specific complexes unknown
  13. 2021 Medium

    Showed mitotic CDK1 phosphorylation of dynein LIC1 selectively engages Pin1 to Hook2-dynein-Nde1-Lis1 complexes, revealing cell-cycle-specific regulation of Hook2 motor complexes.

    Evidence Co-immunoprecipitation of endogenous complexes, phosphomutant analysis, and mitotic phenotype readouts (kinetochore loading, chromosome congression, Golgi fragmentation)

    PMID:34709360

    Open questions at the time
    • Functional output of Pin1 isomerization on Hook2 complexes not fully defined
    • Single-lab study without orthogonal structural confirmation
  14. 2013 Medium

    Documented a HOOK2-ACTN3 fusion from a t(11;19) translocation in an ovarian cancer line, a structural genomic event involving HOOK2.

    Evidence Array breakpoint mapping, PCR/sequencing across genomic and cDNA breakpoints, and 2D Western blot detection of the fusion protein in SKOV-3 cells

    PMID:23362175

    Open questions at the time
    • Functional consequence of the HOOK2 portion of the fusion uncharacterized
    • Not shown to be recurrent or oncogenic
  15. 2025 Low

    Associated HOOK2 with trophoblast invasiveness under hemodynamic stress in the context of preeclampsia.

    Evidence RNA sequencing of amniotic fluid and siRNA knockdown in HTR-8/SVneo trophoblast cells with invasion/migration assays under shear stress

    PMID:41226568

    Open questions at the time
    • No mechanistic pathway placement connecting HOOK2 to invasion
    • Single study, not independently confirmed
    • Link to known centrosomal/transport functions unestablished

Open questions

Synthesis pass · forward-looking unresolved questions
  • How HOOK2-specific FHF complexes structurally discriminate their cargoes and how its centrosomal scaffolding and cargo-transport roles are mechanistically integrated remain unresolved.
  • No structure of a HOOK2-containing FHF-dynein complex
  • Regulatory inputs that switch HOOK2 between ciliary, polarity, aggresome, and transport functions undefined

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060090 molecular adaptor activity 3 GO:0008092 cytoskeletal protein binding 2
Localization
GO:0005815 microtubule organizing center 4 GO:0005856 cytoskeleton 3 GO:0005794 Golgi apparatus 2 GO:0005929 cilium 1
Pathway
R-HSA-5653656 Vesicle-mediated transport 3 R-HSA-1640170 Cell Cycle 2 R-HSA-1852241 Organelle biogenesis and maintenance 1
Partners
CENP-FCEP110FHIP2AFTSLRGUK1PARD6APCM1RAB8A
Complex memberships
FTS-Hook-FHIP (FHF) complexHook2-dynein-Nde1-Lis1 complexLRGUK1-Hook-RIMBP3-KLC3 manchette complex

Evidence

Reading pass · 15 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2006 Hook2 localizes to the centrosome throughout all phases of the cell cycle via its C-terminal domain, which directly binds to centriolin/CEP110. Mislocalized wild-type or mutant Hook2 perturbs endogenous centrosomal and pericentrosomal proteins. Interference with Hook2 function results in loss of radial microtubule organization and defective microtubule regrowth after nocodazole-induced depolymerization. Direct binding assay (C-terminal domain of Hook2 and centriolin/CEP110), immunofluorescence localization through cell cycle, dominant-negative overexpression with centrosome/microtubule phenotype readout Traffic (Copenhagen, Denmark) High 17140400
2007 Hook2 overexpression promotes accumulation of the cystic fibrosis transmembrane regulator (CFTR) in aggresomes without altering its biochemical properties or steady-state level. A dominant-negative form of Hook2 lacking the centriolin-binding C-terminal domain inhibits aggresome formation, indicating Hook2 contributes to pericentrosomal localization of aggresomes by promoting microtubule-based delivery of protein aggregates. Overexpression and dominant-negative expression of Hook2 with CFTR aggresome formation assay; immunofluorescence BMC cell biology Medium 17540036
2008 Hook2 (along with Hook1 and Hook3) forms part of a multiprotein FTS-Hook-FHIP (FHF) complex. Hook proteins associate with a conserved C-terminal motif of FTS, form homo- and heterodimers, and the ~500-kDa FHF complex interacts with components of both class B and class C of the HOPS complex to promote vesicle trafficking and/or fusion. Hook2 can interact interchangeably with other Hook proteins within this complex. Proteomic analysis (mass spectrometry) of purified FTS complexes from HEK293T cells, yeast two-hybrid, co-immunoprecipitation, siRNA depletion with endosomal trafficking readout Molecular biology of the cell High 18799622
2009 MSUT-2 (the human ortholog of C. elegans SUT-2) binds specifically to HOOK2 among the three human HOOK paralogs (HOOK1, HOOK2, HOOK3), as demonstrated by yeast two-hybrid and in vitro protein binding assays, suggesting the SUT-2/HOOK interaction is conserved across animal phyla. Yeast two-hybrid screen, in vitro protein binding assay Human molecular genetics Medium 19273536
2009 CENP-F binds Hook2 at the centrosome, as identified by yeast two-hybrid screen and confirmed by co-immunoprecipitation. Ablation of CENP-F eliminates microtubule repolymerization from the centrosome after nocodazole treatment but not from the Golgi. Expression of a CENP-F truncation containing only the Hook2-binding domain recapitulates the centrosome-specific microtubule nucleation defect, indicating CENP-F acts through Hook2 at the centrosome. Yeast two-hybrid, co-immunoprecipitation with novel immunochemical reagents, CENP-F knockout cells with MT repolymerization assay, truncation expression Molecular biology of the cell High 19793914
2011 Hook2 localizes at the Golgi apparatus and centrosome/basal body in human retinal epithelial cells. Hook2 depletion disrupts ciliogenesis before formation of the ciliary vesicle at the distal tip of the mother centriole. Hook2 interacts with and stabilizes PCM1 (pericentriolar material protein 1), and co-immunoprecipitates with GFP::Rab8a and PCM1 in a complex. Overexpression of GFP::Rab8a can rescue the ciliogenesis defect caused by Hook2 depletion. siRNA depletion with ciliogenesis phenotype readout, yeast two-hybrid, co-immunoprecipitation, GFP::Rab8a rescue experiment, immunofluorescence localization Molecular biology of the cell High 21998199
2015 LRGUK-1 binds directly to HOOK2 via its GUK-like domain, as shown by yeast two-hybrid and co-immunoprecipitation. Both proteins co-localize to the manchette during spermatogenesis. Loss of LRGUK-1 causes defects in basal body attachment, axoneme extension, and manchette microtubule organization that may be mediated in part through its interaction with HOOK2. Yeast two-hybrid screen of adult testis library, co-immunoprecipitation/co-localization, domain mapping (GUK-like domain essential for HOOK2 binding), LRGUK-1 knockout mouse with spermatogenesis phenotype PLoS genetics Medium 25781171
2016 LRGUK1 binds to HOOK2 (as well as HOOK1 and HOOK3) specifically through its GUK-like domain, confirmed by yeast two-hybrid and validated biochemically. All three HOOK proteins localize to the manchette, and LRGUK1 functions within a multiprotein complex (including HOOK proteins, RIMBP3, and KLC3) required for manchette-based microtubule dynamics in haploid male germ cells. Yeast two-hybrid screen, domain mapping (GUK-like domain required for HOOK2 binding), biochemical validation, co-localization studies FASEB journal Medium 28003339
2016 Hook2 interacts with PAR6α via its C-terminal domain binding to the aPKC-binding domain of PAR6α, localizing PAR6α to the centrosome during polarized cell migration. Hook2 depletion decreases PAR6α at the centrosome and disrupts Golgi reorientation toward the migration front. Overexpression of Hook2 induces aggresome formation with recruitment of PAR6α, aPKC, and PAR3. Co-immunoprecipitation, domain mapping, siRNA depletion with Golgi reorientation and PAR6α localization readout, overexpression phenotype analysis Scientific reports Medium 27624926
2020 The FHF complex interacts with the AP-4 adaptor protein complex via direct binding of the AP-4 μ4 subunit to coiled-coil domains in Hook1 and Hook2. Knockdown of FHF subunits (including Hook2) causes dispersal of AP-4 and its cargo ATG9A from the perinuclear region, consistent with FHF coupling organelles to dynein-dynactin for retrograde microtubule transport. Affinity purification-mass spectrometry, direct binding assay (μ4 subunit to Hook coiled-coil domains), siRNA knockdown with AP-4/ATG9A localization readout Molecular biology of the cell High 32073997
2021 FTS-FHIP2A-Hook2 complexes associate with Rab1A-tagged ER-to-Golgi cargos, and FHIP2A is involved in the motility of Rab1A tubules. These Hook2-containing FHF complexes move with dynein and dynactin in single-molecule in vitro reconstitution assays. This contrasts with FTS-FHIP1B-Hook1/Hook3 complexes that associate with Rab5-positive early endosomes, demonstrating cargo specificity through combinatorial FHF assembly. Proteomic interactome of each FHIP protein, live-cell imaging, single-molecule in vitro reconstitution with dynein/dynactin, siRNA knockdown of FHIP2A with Rab1A tubule motility readout eLife High 34882091
2021 Mitotic phosphorylation of LIC1-CTD (dynein light intermediate chain 1 C-terminal domain) at cdk1 sites engages the prolyl isomerase Pin1 predominantly to Hook2-dynein-Nde1-Lis1 complexes but not to dynein-spindly-dynactin complexes, indicating Hook2-containing dynein complexes are selectively regulated by mitotic phosphorylation and Pin1. Co-immunoprecipitation of endogenous complexes, phosphomutant analysis, cell biological phenotype readouts (kinetochore loading, chromosome congression, mitotic Golgi fragmentation) The Journal of cell biology Medium 34709360
2013 In the ovarian cancer cell line SKOV-3, exon 14 of HOOK2 on chromosome 19 is fused with exon 2 of ACTN3 from chromosome 11 in a der(19)t(11;19) translocation, producing a fusion protein. The breakpoint in HOOK2 introduces a frameshift in ACTN3 predicted to cause loss of ACTN3 function; the fusion protein was detected by 2D Western blotting at the calculated molecular mass. Array-based breakpoint mapping, PCR spanning breakpoints on genomic DNA and cDNA, sequencing, 2D Western blotting Genes, chromosomes & cancer Medium 23362175
2019 Hook2 is present at the midbody and centrosome during cytokinesis in human epithelial cells. Knockdown of Hook2 causes disappearance of LSR, tricellulin, PAR3, and other molecules from the centrosome during cytokinesis, while the epithelial barrier is maintained, indicating Hook2 is required for recruitment of multiple proteins to the centrosome during cell division. Immunofluorescence localization, siRNA knockdown with centrosome protein localization readout during cytokinesis The journal of histochemistry and cytochemistry Medium 31662022
2025 HOOK2 mRNA is significantly upregulated in second-trimester amniotic fluid from women who later develop preeclampsia, and its expression increases with higher shear stress in trophoblast cells. Knockdown of HOOK2 significantly increases trophoblast invasion while migration shows no significant change, suggesting HOOK2 negatively regulates trophoblast invasiveness under hemodynamic stress conditions. RNA sequencing of amniotic fluid, siRNA knockdown in HTR-8/SVneo cells with invasion and migration assays under shear stress conditions International journal of molecular sciences Low 41226568

Source papers

Stage 0 corpus · 45 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2009 SUT-2 potentiates tau-induced neurotoxicity in Caenorhabditis elegans. Human molecular genetics 95 19273536
2008 An FTS/Hook/p107(FHIP) complex interacts with and promotes endosomal clustering by the homotypic vacuolar protein sorting complex. Molecular biology of the cell 95 18799622
2015 Metabolomic Quantitative Trait Loci (mQTL) Mapping Implicates the Ubiquitin Proteasome System in Cardiovascular Disease Pathogenesis. PLoS genetics 77 26540294
2015 LRGUK-1 is required for basal body and manchette function during spermatogenesis and male fertility. PLoS genetics 60 25781171
2006 Hook2 localizes to the centrosome, binds directly to centriolin/CEP110 and contributes to centrosomal function. Traffic (Copenhagen, Denmark) 55 17140400
2011 Hook2 is involved in the morphogenesis of the primary cilium. Molecular biology of the cell 52 21998199
2007 Hook2 contributes to aggresome formation. BMC cell biology 45 17540036
2024 DNA methylation and type 2 diabetes: a systematic review. Clinical epigenetics 40 38755631
2014 Overexpression of the truncated form of High Mobility Group A proteins (HMGA2) in human myometrial cells induces leiomyoma-like tissue formation. Molecular human reproduction 40 25542836
2005 Serological identification of tumor antigens of esophageal squamous cell carcinoma. International journal of oncology 40 15586227
2021 Cytoplasmic dynein-1 cargo diversity is mediated by the combinatorial assembly of FTS-Hook-FHIP complexes. eLife 37 34882091
2018 Identification of specific and common diagnostic antibody markers for gastrointestinal cancers by SEREX screening using testis cDNA phage library. Oncotarget 30 29719626
2009 Murine CENP-F regulates centrosomal microtubule nucleation and interacts with Hook2 at the centrosome. Molecular biology of the cell 30 19793914
2020 Maternal diabetes and obesity influence the fetal epigenome in a largely Hispanic population. Clinical epigenetics 29 32075680
2020 The FTS-Hook-FHIP (FHF) complex interacts with AP-4 to mediate perinuclear distribution of AP-4 and its cargo ATG9A. Molecular biology of the cell 27 32073997
2016 LRGUK1 is part of a multiprotein complex required for manchette function and male fertility. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 23 28003339
2017 Altered intragenic DNA methylation of HOOK2 gene in adipose tissue from individuals with obesity and type 2 diabetes. PloS one 21 29228058
2015 Hook proteins: association with Alzheimer pathology and regulatory role of hook3 in amyloid beta generation. PloS one 21 25799409
2020 Sexually dimorphic DNA-methylation in cardiometabolic health: A systematic review. Maturitas 20 32252966
2018 Mutations in known disease genes account for the majority of autosomal recessive retinal dystrophies. Clinical genetics 18 30054919
2016 SiRNA/DOX lodeded chitosan based nanoparticles: Development, Characterization and in vitro evaluation on A549 lung cancer cell line. Cellular and molecular biology (Noisy-le-Grand, France) 18 27755958
2020 Dicoumarol suppresses HMGA2-mediated oncogenic capacities and inhibits cell proliferation by inducing apoptosis in colon cancer. Biochemical and biophysical research communications 17 32063361
2016 Hook2, a microtubule-binding protein, interacts with Par6α and controls centrosome orientation during polarized cell migration. Scientific reports 15 27624926
2022 Long non-coding RNA HIF1A-AS2 modulates the proliferation, migration, and phenotypic switch of aortic smooth muscle cells in aortic dissection via sponging microRNA-33b. Bioengineered 14 35212609
2020 The pro-migration and anti-apoptosis effects of HMGA2 in HUVECs stimulated by hypoxia. Cell cycle (Georgetown, Tex.) 13 33315504
2021 Phosphorylation and Pin1 binding to the LIC1 subunit selectively regulate mitotic dynein functions. The Journal of cell biology 12 34709360
2022 Blood cell DNA methylation biomarkers in preclinical malignant pleural mesothelioma: The EPIC prospective cohort. International journal of cancer 9 36305648
2019 Epigenetic association analysis of clinical sub-phenotypes in patients with polycystic ovary syndrome (PCOS). Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 9 30782033
2018 Multiple Roles, Multiple Adaptors: Dynein During Cell Cycle. Advances in experimental medicine and biology 9 30637687
2012 The expression of HMGA2 varies strongly among colon carcinomas. Anticancer research 9 22593436
2020 Effect of Pleomorphic Adenoma Gene 1 Deficiency on Selected Behaviours in Adult Mice. Neuroscience 8 33346119
2019 Localization of Tricellular Tight Junction Molecule LSR at Midbody and Centrosome During Cytokinesis in Human Epithelial Cells. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 8 31662022
2019 Rho-kinase and PKCα Inhibition Induces Primary Cilia Elongation and Alters the Behavior of Undifferentiated and Differentiated Temperature-sensitive Mouse Cochlear Cells. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 5 30917058
2013 Breakpoint characterization of the der(19)t(11;19)(q13;p13) in the ovarian cancer cell line SKOV-3. Genes, chromosomes & cancer 4 23362175
2024 Survival Rate and Chronic Diseases of TCGA Cancer and KoGES Normal Samples by Clustering for DNA Methylation. Life (Basel, Switzerland) 1 38929750
2014 Frequent translocations of 11q13.2 and 19p13.2 in ovarian cancer. Genes, chromosomes & cancer 1 24615723
2026 Genetic and Epigenetic Contributors to Cleft Laterality: Evidence from Monozygotic Mirror Twins and Replication Cohorts. medRxiv : the preprint server for health sciences 0 39606391
2026 Mapping Native Peptide-Peptide Noncovalent Interactions: Insights from Trapped Ion Mobility Spectrometry, Electron- and UV-Fragmentation, Tandem Mass Spectrometry, and Molecular Dynamics. Journal of the American Society for Mass Spectrometry 0 41635028
2026 HOOK2 downregulation compromises the tumorigenic and stemness properties of ovarian cancer cells by increasing endoplasmic reticulum stress. Cell death & disease 0 42031698
2025 Modified screening of MYC promotor region elements using the CRISPR library in ovarian cancer. Journal of ovarian research 0 40176181
2025 Doxorubicin-mediated retardation of aggresome formation enhances Carfilzomib-induced cell death synergistically by augmenting ER stress and proapoptotic signaling. European journal of pharmacology 0 41183585
2025 Investigation of Novel Predictive Biomarkers for Preeclampsia in Second-Trimester Amniotic Fluid. International journal of molecular sciences 0 41226568
2025 Fasting and Postprandial DNA Methylation Signatures in Adipose Tissue from Asymptomatic Individuals with Metabolic Alterations. International journal of molecular sciences 0 41373473
2025 AI/ML-Assisted Detection of HMGA2 RNA Isoforms in Prostate Cancer Patient Tissue. International journal of molecular sciences 0 41516076
2023 Cellular carcinogenesis in preleukemic conditions:drivers and defenses. Fukushima journal of medical science 0 37952978

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