Affinage

VDAC3

Non-selective voltage-gated ion channel VDAC3 · UniProt Q9Y277

Length
283 aa
Mass
30.7 kDa
Annotated
2026-04-28
43 papers in source corpus 27 papers cited in narrative 27 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

VDAC3 is a β-barrel voltage-dependent anion channel of the mitochondrial outer membrane that functions as a redox-sensitive regulator of mitochondrial integrity, ROS homeostasis, and inter-organellar signaling. Its unique complement of cysteine residues forms intra- and intermolecular disulfide bonds that gate channel conductance under oxidizing conditions, mediate homo- and hetero-oligomerization with VDAC1/VDAC2, and are indispensable for protecting mitochondria from oxidative stress and maintaining electron transport chain function (PMID:26407725, PMID:26760765, PMID:35180474, PMID:40588209, PMID:40875006). The N-terminal α-helix is the key structural determinant distinguishing VDAC3 from VDAC1, suppressing β-barrel aggregation and governing isoform-specific channel properties, while cardiolipin selectively stabilizes the open conductive state by modulating N-terminal helix dynamics (PMID:20434446, PMID:30674561, PMID:41575209). Beyond mitochondria, VDAC3 localizes to the mother centriole where it recruits Mps1 kinase to regulate centriole assembly and suppress primary ciliogenesis in cycling cells, and its protein levels are controlled by multiple E3 ubiquitin ligases (FBXW7, SPOP, Trim15) linking it to ferroptosis, autophagy, and mitophagy regulation (PMID:22935710, PMID:23388454, PMID:34869326, PMID:39549880, PMID:41617671).

Mechanistic history

Synthesis pass · year-by-year structured walk · 11 steps
  1. 1998 High

    Identification that VDAC3 exists as tissue-specific splice isoforms differing by Met39, both targeting to mitochondria and capable of complementing yeast porin function, established VDAC3 as a functional mitochondrial channel with regulated diversity.

    Evidence cDNA cloning, tagged-construct transfection, yeast complementation of YVDAC-deficient strain

    PMID:9804816

    Open questions at the time
    • Human tissue-specific expression pattern of splice variants not mapped
    • No electrophysiological characterization of channel properties at this stage
  2. 2004 High

    Discovery of VDAC3 as a structural component of sperm outer dense fibers revealed an extramitochondrial role, expanding the functional repertoire beyond channel activity.

    Evidence Peptide sequencing of purified bovine sperm ODF, isoform-specific antibodies, immunoelectron microscopy

    PMID:14739283

    Open questions at the time
    • Structural role in ODF not mechanistically defined
    • Whether ODF-associated VDAC3 retains channel activity unknown
  3. 2010 High

    Systematic isoform comparison in yeast and knockout mice revealed that VDAC3 is functionally distinct from VDAC1/VDAC2: it poorly complements respiratory growth, sensitizes cells to oxidative stress, and its N-terminal 20 residues are the key determinant of these isoform-specific differences, while mouse knockouts showed tissue-specific defects in complex IV activity.

    Evidence Yeast complementation with domain-swap chimeras, ROS and lifespan assays; VDAC3 KO mouse respirometry, enzyme activity, electron microscopy

    PMID:20138821 PMID:20434446 PMID:20875390

    Open questions at the time
    • Molecular basis of N-terminal functional specificity at atomic resolution not resolved
    • Mechanism linking VDAC3 to complex IV activity unknown
  4. 2012 High

    Discovery that VDAC3 localizes to the mother centriole and recruits Mps1 kinase to suppress ciliogenesis established a completely unexpected non-mitochondrial function in cell cycle-coupled centriole regulation.

    Evidence Co-IP, confocal imaging, RNAi knockdown/overexpression with cilia quantification, epistasis with Mps1

    PMID:22935710 PMID:23388454

    Open questions at the time
    • How VDAC3 is targeted to the centriole versus mitochondria not determined
    • Whether centriolar VDAC3 retains channel-forming ability unknown
  5. 2014 High

    Systematic interactome mapping in HeLa cells identified VDAC3 interactions with tubulins, chaperones, proteasome components, and redox enzymes including protein disulfide isomerase, suggesting a scaffold function integrating ROS homeostasis and protein quality control.

    Evidence Tandem-affinity purification of dual-tagged VDAC3, 2D gel/MS, immunoprecipitation validation

    PMID:24865465

    Open questions at the time
    • Direct versus indirect interactions not fully resolved for all partners
    • Functional significance of individual interactions not tested
  6. 2016 High

    In vitro electrophysiology and mass spectrometry established that VDAC3 cysteines exist in multiple oxidation states in native mitochondria and form disulfide bonds that suppress channel gating, directly demonstrating VDAC3 functions as a redox sensor of the intermembrane space.

    Evidence Reconstituted planar lipid bilayer electrophysiology with redox agents and cysteine mutagenesis; UHPLC/HR-MS of native rat liver VDAC3

    PMID:26407725 PMID:26760765 PMID:27989743

    Open questions at the time
    • In vivo confirmation that redox-dependent gating changes affect metabolite flux not obtained
    • Specific IMS redox couples regulating VDAC3 cysteines not identified
  7. 2019 High

    Mapping of aggregation-prone regions to β7–β9 strands and the stabilizing role of the α1–β7–β9 interaction provided the first biophysical account of how the N-terminal helix maintains VDAC3 fold stability, explaining why N-terminal perturbations are so functionally consequential.

    Evidence Systematic cysteine-to-thiol mutagenesis with CD and UV scattering spectroscopy

    PMID:30674561

    Open questions at the time
    • No high-resolution atomic structure of hVDAC3 determined experimentally
    • Aggregation intermediates not characterized in a membrane environment
  8. 2020 High

    Quantitative comparison showed VDAC3 forms channels similar to VDAC1 in conductance and selectivity but interacts with α-synuclein and tubulin with 10–100-fold lower on-rates, with cysteines regulating these interactions, establishing isoform-specific cytosolic protein recognition.

    Evidence Recombinant reconstitution in planar lipid bilayers, cysteine-scanning mutagenesis, single-channel kinetics

    PMID:31935282

    Open questions at the time
    • Physiological consequence of reduced α-synuclein/tubulin binding in vivo not established
    • Whether cysteine oxidation state modulates these interactions under physiological conditions untested
  9. 2021 High

    Identification of FBXW7 as the first E3 ubiquitin ligase targeting VDAC3 for proteasomal degradation connected VDAC3 protein levels to autophagy and ferroptosis sensitivity in leukemia cells.

    Evidence Co-IP, ubiquitination assay, lentiviral manipulation, xenograft model

    PMID:34869326

    Open questions at the time
    • Specific ubiquitination sites on VDAC3 not mapped
    • Whether FBXW7-VDAC3 axis operates in non-cancer contexts unknown
  10. 2022 High

    Multiple studies converged to show that VDAC3 cysteines are indispensable for protecting mitochondria from ROS-induced damage: VDAC3 knockout exacerbated redox cycler toxicity and a cysteine-null mutant failed to rescue, while disease-associated PTMs (over-oxidation, deamidation) alter channel function, and the BDNF-AS/FBXW7 axis regulates VDAC3 levels in gastric cancer ferroptosis.

    Evidence KO/cysteine-null complementation in HAP1 cells with respirometry; HR-MS of VDAC3 from ALS-SOD1 model; BDNF-AS/WDR5/FBXW7 ChIRP/RIP/ChIP in gastric cancer

    PMID:35180474 PMID:35280682 PMID:36555496

    Open questions at the time
    • How specific cysteine oxidation states individually contribute to ROS protection not dissected
    • Whether VDAC3 deamidation occurs in human ALS patients not confirmed
  11. 2025 High

    Recent work completed the mechanistic picture by showing VDAC3 cysteines form defined intra- and intermolecular disulfide bonds mediating VDAC oligomerization, cardiolipin selectively stabilizes the open state by modulating N-terminal dynamics, VDAC3 is uniquely required under oxidative stress for mitochondrial membrane potential and ATP synthesis, and additional E3 ligases (SPOP, Trim15) and m6A regulators control VDAC3 levels linking it to mitophagy and ferroptosis.

    Evidence HR-MS under non-reducing conditions; single-channel electrophysiology with lipid variation and MD simulations; yeast complementation lacking SODs; Co-IP/ubiquitination/m6A analysis

    PMID:39379688 PMID:39549880 PMID:40588209 PMID:40875006 PMID:41575209 PMID:41617671

    Open questions at the time
    • High-resolution experimental structure of hVDAC3 still lacking
    • In vivo significance of VDAC hetero-oligomerization via disulfide bonds untested
    • Relative contributions of transcriptional, m6A, and ubiquitin-mediated regulation of VDAC3 in different tissues not compared

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key open questions include the atomic-resolution structure of hVDAC3, the mechanism by which VDAC3 is differentially targeted to centrioles versus mitochondria, whether cysteine-dependent redox sensing directly controls metabolite flux in vivo, and how the multiple E3 ligase and m6A regulatory inputs are integrated to set VDAC3 protein levels in different physiological and disease contexts.
  • No experimental high-resolution structure of hVDAC3
  • Dual localization mechanism (mitochondria vs. centriole) unresolved
  • In vivo metabolite flux through VDAC3 not measured

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0005215 transporter activity 5 GO:0140299 molecular sensor activity 5 GO:0005198 structural molecule activity 1
Localization
GO:0005739 mitochondrion 5 GO:0005815 microtubule organizing center 2 GO:0005886 plasma membrane 1
Pathway
R-HSA-8953897 Cellular responses to stimuli 4 R-HSA-1430728 Metabolism 2 R-HSA-1852241 Organelle biogenesis and maintenance 2 R-HSA-5357801 Programmed Cell Death 2 R-HSA-9612973 Autophagy 1
Partners
ACSL4FBXW7SNCASPOPTRIM15TTKVDAC1VDAC2
Complex memberships
VDAC1-VDAC3 hetero-oligomerVDAC2-VDAC3 hetero-oligomer

Evidence

Reading pass · 27 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2004 VDAC2 and VDAC3 (but not VDAC1) are abundant structural proteins in bovine sperm outer dense fibers (ODF), a cytoskeletal component of the flagellum, localizing outside of mitochondria and suggesting a non-channel structural role in sperm. Peptide sequencing of purified ODF proteins, isoform-specific antibodies, immunoblot, immunofluorescence microscopy, and transmission electron immunomicroscopy The Journal of biological chemistry High 14739283
1998 VDAC3 exists as two isoforms generated by tissue-specific alternative splicing of a 3-base exon encoding Met39; both isoforms localize to mitochondria in transfected mammalian cells, and the Met39 residue modulates VDAC3 channel function as shown by complementation of YVDAC-deficient yeast. cDNA cloning, transfection with fluorescent/epitope-tagged constructs, yeast complementation assay The Journal of biological chemistry High 9804816
2010 VDAC3 has limited ability to complement porin-less yeast for mitochondrial respiration and has no influence on ROS control, unlike VDAC1 and VDAC2; over-expression of VDAC3 causes dramatic sensitivity to oxidative stress and shorter lifespan under respiratory conditions. Yeast complementation assay, real-time PCR, yeast survival/aging assays Biochimica et biophysica acta High 20138821
2010 Swapping the VDAC3 N-terminal 20 amino acids with those from VDAC1 fully restores mitochondrial respiration complementation activity and ROS modulation in porin-less yeast, and extends yeast lifespan, establishing the N-terminus as the key functional determinant distinguishing VDAC3 from VDAC1. N-terminal domain swap chimeras, yeast complementation assay, ROS measurement, lifespan assay FEBS letters High 20434446
2010 In VDAC3-deficient mice, cardiac mitochondria show decreased apparent affinity for ADP and a specific defect in respiratory complex IV activity, whereas gastrocnemius muscle mitochondria ADP affinity is unaffected; structural aberrations of mitochondria correlate with these functional changes, demonstrating muscle-type specificity of VDAC3 function in vivo. VDAC3 knockout mice, in situ mitochondrial respiration, respiratory enzyme activity assays, electron microscopy Biochimica et biophysica acta High 20875390
2012 VDAC3 is present at the mother centriole and recruits the Mps1 kinase to centrosomes by directly binding the centrosome localization domain of Mps1, thereby modulating centriole assembly. Co-immunoprecipitation, confocal imaging, centrosome localization domain mapping, RNAi knockdown with centriole assembly phenotype Cell cycle (Georgetown, Tex.) High 22935710
2013 VDAC3 depletion causes inappropriate ciliogenesis in cycling cells, and VDAC3 overexpression suppresses ciliogenesis in quiescent cells; the VDAC3-Mps1 module at the centrosome promotes ciliary disassembly during cell cycle entry, placing VDAC3 as a negative regulator of primary cilia assembly. RNAi knockdown, GFP-VDAC3 overexpression, immunofluorescence-based cilia quantification, epistasis with Mps1 targeting Cell cycle (Georgetown, Tex.) High 23388454
2015 VDAC3 gating activity is activated by reducing agents (DTT) and S-nitrosoglutathione (GSNO), and by cysteine-to-alanine mutations, indicating that an intramolecular disulfide bond between the N-terminal region and the bottom of the pore suppresses VDAC3 channel gating under oxidizing conditions. Recombinant protein reconstitution into planar lipid bilayers, redox agent treatment, site-directed cysteine mutagenesis, single-channel electrophysiology Biochimica et biophysica acta High 26407725
2016 VDAC3 cysteines (particularly Cys2/Cys8, which can form a disulfide bridge) and Cys122 are in different oxidation states in native mitochondria and regulate pore stability and conductance; the protein acts as a redox sensor reporting oxidative conditions in the mitochondrial intermembrane space. Mass spectrometry of native and recombinant VDAC3, site-directed mutagenesis of individual cysteines, SDS-PAGE mobility shift, electrophysiology, yeast complementation, circular dichroism Oncotarget High 26760765
2016 High-resolution mass spectrometry of rat liver mitochondrial VDAC3 reveals that cysteines 36, 65, 165, and 229 are oxidized to sulfonic acid, while methionines are oxidized to methionine sulfoxide, consistent with VDAC3 being exposed to a strongly oxidizing intermembrane space environment. SDS-PAGE, tryptic/chymotryptic digestion, UHPLC/High Resolution ESI-MS/MS Biochimica et biophysica acta. Biomembranes High 27989743
2014 VDAC3 localizes to mitochondria in HeLa cells and interacts with cytoskeletal proteins (tubulins), stress sensors, chaperones, proteasome components, and redox enzymes including protein disulfide isomerase, suggesting VDAC3 acts as an organizer of protein complexes involved in ROS homeostasis and protein quality control. Stable cell line with dual-tagged VDAC3, tandem-affinity purification, 2D gel electrophoresis, mass spectrometry, live-cell imaging, immunoprecipitation validation Molecular bioSystems High 24865465
2020 VDAC3 forms stable, highly conductive, weakly anion-selective voltage-gated channels similar to VDAC1, but interacts with cytosolic proteins α-synuclein and tubulin with 10–100-fold reduced on-rates; cysteine scanning mutagenesis shows VDAC3's cysteine residues regulate interaction with α-synuclein, demonstrating isoform-specific cytosolic protein regulation. Recombinant protein reconstitution in planar lipid bilayers, single-channel electrophysiology, cysteine-scanning mutagenesis The Journal of general physiology High 31935282
2022 VDAC3 depletion significantly exacerbates cytotoxicity of redox cyclers (menadione, paraquat) and complex I inhibitors (rotenone), causing uncontrolled mitochondrial ROS accumulation; high-resolution respirometry shows that VDAC3 cysteines are indispensable for its ability to counteract ROS-induced oxidative stress. VDAC3 knockdown/knockout (HAP1-ΔVDAC3 cells), cysteine-null VDAC3 mutant complementation, high-resolution respirometry, ROS measurement Redox biology High 35180474
2021 FBXW7 functions as an E3 ubiquitin ligase for VDAC3, mediating its ubiquitination and proteasomal degradation; autophagy activation (rapamycin) increases VDAC3 degradation via this pathway and sensitizes leukemia cells to erastin-induced ferroptosis. Immunoprecipitation, UbiBrowser prediction followed by experimental confirmation, lentiviral knockdown/overexpression, xenograft model Frontiers in cell and developmental biology High 34869326
2022 The BDNF-AS lncRNA recruits WDR5 to enhance FBXW7 transcription; FBXW7 then ubiquitinates VDAC3 to reduce its protein level, thereby protecting gastric cancer cells from ferroptosis. ChIRP, RIP, ChIP, co-IP, in vivo xenograft model, qRT-PCR International journal of biological sciences High 35280682
2022 Enteroviral 2B protein directly interacts with VDAC3; VDAC3 knockdown suppresses enterovirus 71 replication and reduces virus-induced mitochondrial ROS generation, establishing VDAC3 as an essential host factor for enteroviral ROS-dependent replication. Co-immunoprecipitation-proteomic analysis, siRNA knockdown, single-round viral replication assay, mitochondrial ROS measurement Viruses High 36016340
2023 Dankastatin B covalently targets Cys65 of VDAC3 in breast cancer cells; VDAC3 knockdown confers hypersensitivity to dankastatin B-mediated antiproliferative effects, indicating VDAC3 is at least partially responsible for the drug's anticancer mechanism. Activity-based protein profiling chemoproteomic approach, covalent interaction validation, siRNA knockdown, antiproliferative assays Chembiochem : a European journal of chemical biology High 36964942
2019 The β7–β9 strand region of hVDAC3 is highly aggregation prone; an α1–β7–β9 interaction (involving the N-terminal α-helix) suppresses aggregation, and perturbation of this interaction promotes aggregation through a partially unfolded intermediate. Systematic cysteine thiol-replacement mutagenesis, far-UV circular dichroism, UV scattering spectroscopy The Journal of general physiology High 30674561
2022 Specific post-translational modifications of VDAC3 in ALS-SOD1 model cells include over-oxidation, deamidation, and succination at specific residues; deamidation of Asn215 alone alters single-channel behavior in artificial membranes, demonstrating that disease-related oxidative PTMs functionally impact VDAC3. nUHPLC/High-Resolution nESI-MS/MS of enriched VDAC3 from NSC34-SOD1G93A cells, planar lipid bilayer electrophysiology of deamidated mutant International journal of molecular sciences High 36555496
2024 SPOP functions as an E3 ubiquitin ligase that ubiquitinates and degrades VDAC3; ALKBH5 demethylase reduces SPOP mRNA stability (via m6A in 3'UTR), decreasing SPOP-mediated VDAC3 degradation and promoting ferroptosis; IGF2BP2 stabilizes SPOP mRNA to inhibit ferroptosis, placing VDAC3 downstream of ALKBH5/IGF2BP2/SPOP axis in diabetic cardiomyopathy. Co-immunoprecipitation, ubiquitination assay, m6A modification analysis, RIP, mRNA stability assay in cardiomyocytes Free radical biology & medicine Medium 39549880
2025 ALKBH5 m6A demethylase reduces VDAC3 mRNA stability by decreasing m6A modification, and YTHDF1 acts as the m6A reader that enhances VDAC3 mRNA stability; VDAC3 overexpression reduces etoposide-induced cellular senescence and promotes osteogenic differentiation in bone mesenchymal stromal cells. RIP assay, luciferase reporter, Me-RIP (m6A methylation analysis), Western blot, alkaline phosphatase and alizarin red S staining Scientific reports Medium 39379688
2025 Trim15 E3 ubiquitin ligase stabilizes VDAC3 via K6-linked ubiquitination (rather than promoting degradation), suppressing autophagy/mitophagy and elevating ROS; VDAC3 knockdown enhances autophagy and reduces ROS, defining a Trim15-VDAC3-mitophagy axis in hypopharyngeal squamous cell carcinoma. Co-immunoprecipitation, ubiquitination linkage analysis, siRNA knockdown, flow cytometry for ROS/mitophagy, xenograft model Cell death discovery Medium 41617671
2025 Cardiolipin uniquely retains hVDAC3 in an open-like conductive state, while anionic headgroups, negative protein-bilayer mismatch, and increased membrane viscosity optimize channel stability; lipid composition selectively modulates hVDAC3 N-terminal helix dynamics without altering global β-barrel fold. Single-channel electrophysiology, all-atom molecular dynamics simulations, systematic lipid variation Protein science : a publication of the Protein Society High 41575209
2025 In yeast lacking endogenous VDACs and superoxide dismutases, hVDAC3 (but not hVDAC1 or hVDAC2) maintains mitochondrial membrane potential, morphology, and efficient ATP synthesis under oxidative stress; cysteine-depleted hVDAC3 loses this protective function, confirming that hVDAC3 cysteines are essential for oxidative stress protection. Heterologous expression in yeast strains lacking POR1/POR2 and SOD1/SOD2, growth assays, mitochondrial membrane potential measurement, bioenergetic profiling Biochimica et biophysica acta. Bioenergetics High 40588209
2025 Mass spectrometry characterization of rat VDAC3 revealed three intramolecular disulfide bonds and seven intermolecular disulfide bonds between rVDAC3 and rVDAC1 or rVDAC2, demonstrating that disulfide bridges directly mediate homo- and hetero-oligomerization of VDAC isoforms. UHPLC/High Resolution ESI-MS/MS after enzymatic digestion; non-reducing conditions to preserve disulfide bonds Analytical and bioanalytical chemistry High 40875006
2025 VDAC3 KO in HeLa cells dramatically downregulates key electron transport chain members and shifts mitochondria to glutamine-dependent metabolism, demonstrating a non-redundant role of VDAC3 (not compensated by VDAC1/VDAC2) in supporting ETC function and cancer cell metabolic adaptability. VDAC3 knockout HeLa cells, comparative proteomics, respirometry, metabolic flux analysis bioRxivpreprint Medium bio_10.1101_2025.02.20.639106
2034 ACSL4 interacts with both ZIP7 (ER iron efflux channel) and VDAC3 (mitochondrial iron influx channel) at ER-mitochondria contact sites; VDAC3 knockdown reverses mitochondrial iron overload under PFOS exposure, establishing VDAC3 as a mitochondrial iron influx channel regulated by ACSL4-mediated ZIP7-VDAC3 interaction. Co-immunoprecipitation of ACSL4-VDAC3 in mouse liver and L-02 cells, siRNA knockdown of VDAC3, iron measurement The Science of the total environment Medium 39579909

Source papers

Stage 0 corpus · 43 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2010 Characterization of human VDAC isoforms: a peculiar function for VDAC3? Biochimica et biophysica acta 137 20138821
2004 Voltage-dependent anion-selective channels VDAC2 and VDAC3 are abundant proteins in bovine outer dense fibers, a cytoskeletal component of the sperm flagellum. The Journal of biological chemistry 96 14739283
2022 The lncRNA BDNF-AS/WDR5/FBXW7 axis mediates ferroptosis in gastric cancer peritoneal metastasis by regulating VDAC3 ubiquitination. International journal of biological sciences 90 35280682
2016 VDAC3 as a sensor of oxidative state of the intermembrane space of mitochondria: the putative role of cysteine residue modifications. Oncotarget 82 26760765
2011 Arabidopsis kinesin KP1 specifically interacts with VDAC3, a mitochondrial protein, and regulates respiration during seed germination at low temperature. The Plant cell 65 21406623
2015 VDAC3 gating is activated by suppression of disulfide-bond formation between the N-terminal region and the bottom of the pore. Biochimica et biophysica acta 62 26407725
2016 VDAC3 As a Potential Marker of Mitochondrial Status Is Involved in Cancer and Pathology. Frontiers in oncology 60 28066720
2004 All three isoforms of the voltage-dependent anion channel (VDAC1, VDAC2, and VDAC3) are present in mitochondria from bovine, rabbit, and rat brain. Archives of biochemistry and biophysics 58 14759607
2022 Voltage Dependent Anion Channel 3 (VDAC3) protects mitochondria from oxidative stress. Redox biology 57 35180474
2010 Swapping of the N-terminus of VDAC1 with VDAC3 restores full activity of the channel and confers anti-aging features to the cell. FEBS letters 55 20434446
1998 A novel isoform of the mitochondrial outer membrane protein VDAC3 via alternative splicing of a 3-base exon. Functional characteristics and subcellular localization. The Journal of biological chemistry 52 9804816
2020 A lower affinity to cytosolic proteins reveals VDAC3 isoform-specific role in mitochondrial biology. The Journal of general physiology 48 31935282
2013 VDAC3 and Mps1 negatively regulate ciliogenesis. Cell cycle (Georgetown, Tex.) 45 23388454
2021 Autophagy Regulates VDAC3 Ubiquitination by FBXW7 to Promote Erastin-Induced Ferroptosis in Acute Lymphoblastic Leukemia. Frontiers in cell and developmental biology 44 34869326
2010 VDAC3 has differing mitochondrial functions in two types of striated muscles. Biochimica et biophysica acta 37 20875390
2014 Differential targeting of VDAC3 mRNA isoforms influences mitochondria morphology. Proceedings of the National Academy of Sciences of the United States of America 34 24889622
2016 High resolution mass spectrometry characterization of the oxidation pattern of methionine and cysteine residues in rat liver mitochondria voltage-dependent anion selective channel 3 (VDAC3). Biochimica et biophysica acta. Biomembranes 31 27989743
2018 miR-3928v is induced by HBx via NF-κB/EGR1 and contributes to hepatocellular carcinoma malignancy by down-regulating VDAC3. Journal of experimental & clinical cancer research : CR 30 29378599
2021 HSP70-16 and VDAC3 jointly inhibit seed germination under cold stress in Arabidopsis. Plant, cell & environment 29 34173257
2012 VDAC3 regulates centriole assembly by targeting Mps1 to centrosomes. Cell cycle (Georgetown, Tex.) 25 22935710
2014 Live cell interactome of the human voltage dependent anion channel 3 (VDAC3) revealed in HeLa cells by affinity purification tag technique. Molecular bioSystems 24 24865465
2022 Enteroviral 2B Interacts with VDAC3 to Regulate Reactive Oxygen Species Generation That Is Essential to Viral Replication. Viruses 21 36016340
2021 CIPK9 targets VDAC3 and modulates oxidative stress responses in Arabidopsis. The Plant journal : for cell and molecular biology 16 34748255
2017 Association of the VDAC3 gene polymorphism with sperm count in Han-Chinese population with idiopathic male infertility. Oncotarget 16 28431403
2024 N6-methyladenosine modification of SPOP relieves ferroptosis and diabetic cardiomyopathy by enhancing ubiquitination of VDAC3. Free radical biology & medicine 13 39549880
2019 Helix-strand interaction regulates stability and aggregation of the human mitochondrial membrane protein channel VDAC3. The Journal of general physiology 13 30674561
2015 Channel characteristics of VDAC-3 from Arabidopsis thaliana. Biochemical and biophysical research communications 12 25686492
2024 ALKBH5 regulates etoposide-induced cellular senescence and osteogenic differentiation in osteoporosis through mediating the m6A modification of VDAC3. Scientific reports 10 39379688
2022 Specific Post-Translational Modifications of VDAC3 in ALS-SOD1 Model Cells Identified by High-Resolution Mass Spectrometry. International journal of molecular sciences 10 36555496
2023 Voltage-dependent anion channel 3 (VDAC3) mediates P. syringae induced ABA-SA signaling crosstalk in Arabidopsis thaliana. Plant physiology and biochemistry : PPB 6 38109831
2023 Chemoproteomic Profiling Reveals that Anticancer Natural Product Dankastatin B Covalently Targets Mitochondrial VDAC3. Chembiochem : a European journal of chemical biology 5 36964942
2025 Fto-dependent Vdac3 m6A Modification Regulates Neuronal Ferroptosis Induced by the Post-ICH Mass Effect and Transferrin. Neuroscience bulletin 4 39951182
2025 Human VDAC3 as a sensor of the intracellular redox state: contribution to cytoprotection mechanisms in oxidative stress. Biochimica et biophysica acta. Bioenergetics 4 40588209
2025 The VDAC3/DHODH Axis Ameliorates Sepsis-induced Myocardial Injury by Regulating Ferroptosis. Frontiers in bioscience (Landmark edition) 3 40613295
2024 ACSL4-mediated ZIP7-VDAC3 interaction regulates endoplasmic reticulum-mitochondria iron transfer in hepatocytes under PFOS exposure. The Science of the total environment 3 39579909
2018 LSCC SNP variant regulates SOX2 modulation of VDAC3. Oncotarget 3 29854282
2023 Chemoproteomic Profiling Reveals that Anti-Cancer Natural Product Dankastatin B Covalently Targets Mitochondrial VDAC3. bioRxiv : the preprint server for biology 2 36798342
2026 MDP25-VDAC3 Complex Orchestrates Actin Remodeling and Mitochondrial Dynamics to Modulate Innate Immunity in Arabidopsis. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 1 41486573
2026 Protein-lipid interplay governs ion channel gating and bioenergetics in human mitochondrial VDAC3. Protein science : a publication of the Protein Society 0 41575209
2026 Trim15 stabilizes VDAC3 via ubiquitination to suppress autophagy and enhance chemosensitivity in hypopharyngeal squamous cell carcinoma. Cell death discovery 0 41617671
2026 PRELID1 and VDAC3 Coordinate a Senescence-Like State in Germinal Center B Cells to Promote IL-7-Driven Antitumor Immunity in Colorectal Cancer. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 0 41706757
2026 The HPCA1-VDAC3 module mediates the humidity adaptation trade-off by interfering with ROS homeostasis in Arabidopsis thaliana. Journal of genetics and genomics = Yi chuan xue bao 0 41707862
2025 Structural characterization of intra- and intermolecular disulfide bonds in voltage-dependent anion channel 3 (VDAC3) protein from Rattus norvegicus by high-resolution mass spectrometry. Analytical and bioanalytical chemistry 0 40875006