Affinage

FLOT1

Flotillin-1 · UniProt O75955

Round 2 corrected
Length
427 aa
Mass
47.4 kDa
Annotated
2026-04-28
54 papers in source corpus 16 papers cited in narrative 16 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

FLOT1 is a lipid-raft scaffold protein that organizes membrane microdomains and drives clathrin-independent endocytosis, linking membrane trafficking to diverse signaling and metabolic outcomes. FLOT1 homo- and hetero-oligomerizes with flotillin-2 to induce membrane curvature and vesicle budding independently of clathrin and caveolin, mediating uptake of GPI-anchored proteins, cholera toxin, and syndecan-1-dependent triglyceride-rich lipoproteins (PMID:9153235, PMID:16341206, PMID:17600709, PMID:29162604). Through its scaffolding function, FLOT1 nucleates signaling complexes—including a CAP–Cbl ternary complex required for insulin-stimulated glucose uptake and a BCAR1-dependent ERK cascade in cancer cells—and participates in autophagosome–lysosome fusion as part of an SDC1–TGM2–FLOT1–BHMT complex and in macropinosome-dependent mTORC1 activation in podocytes (PMID:11001060, PMID:37928269, PMID:37441590, PMID:41500583). FLOT1 also modulates immune cell phenotypes, promoting M2 macrophage polarization with ferroptosis resistance and driving pro-inflammatory microglial polarization via a FOSL2–EphA2–p38/MAPK axis relevant to Alzheimer's disease pathology (PMID:40108025, PMID:41548752).

Mechanistic history

Synthesis pass · year-by-year structured walk · 10 steps
  1. 1997 High

    Establishing that FLOT1 is an integral membrane protein of caveolae/lipid rafts defined a new structural component of detergent-resistant membrane domains and founded the flotillin protein family.

    Evidence Molecular cloning and detergent-resistant membrane fractionation in brain and other tissues

    PMID:9153235

    Open questions at the time
    • Whether FLOT1 was functionally distinct from caveolins was unknown
    • No endocytic or signaling role yet assigned
  2. 2000 High

    Discovery that FLOT1 scaffolds a CAP–Cbl ternary complex at lipid rafts to enable insulin-stimulated glucose transport established FLOT1's first signaling function and linked it to metabolic regulation.

    Evidence Yeast two-hybrid, reciprocal co-immunoprecipitation, dominant-negative overexpression in 3T3-L1 adipocytes with glucose transport assay

    PMID:11001060

    Open questions at the time
    • Structural basis of the FLOT1–CAP interaction not determined
    • Whether this pathway operates in vivo in whole-animal insulin signaling was untested
  3. 2001 High

    Demonstrating that FLOT1 forms high-order oligomers as an independent scaffolding platform in erythrocyte lipid rafts established that its structural role extends beyond caveolin-containing membranes.

    Evidence Lipid raft isolation from human erythrocytes, sucrose gradient fractionation, oligomer characterization

    PMID:11159550

    Open questions at the time
    • Oligomerization interfaces and stoichiometry undefined
    • Functional consequence of oligomerization for membrane trafficking not yet tested
  4. 2005 High

    Identification of FLOT1-positive puncta as a clathrin- and caveolin-independent endocytic pathway resolved the question of whether lipid raft endocytosis requires a distinct coat-like machinery.

    Evidence TIRF microscopy, immuno-EM, ferro-fluid endosome purification, siRNA knockdown inhibiting GPI-linked protein and cholera toxin uptake

    PMID:16341206

    Open questions at the time
    • Cargo selectivity mechanism for flotillin-mediated endocytosis unknown
    • Dynamin dependence of the pathway not fully resolved
  5. 2007 High

    Showing that FLOT1–FLOT2 coassembly is sufficient to generate membrane curvature and vesicle budding established flotillins as minimal machinery for de novo microdomain formation and endocytosis.

    Evidence Overexpression of flotillin constructs with live-cell imaging and electron microscopy of induced invaginations and vesicles

    PMID:17600709

    Open questions at the time
    • No in vitro reconstitution with purified proteins
    • Post-translational modifications controlling assembly not mapped
  6. 2011 Medium

    Linking FLOT1 to cancer cell proliferation through the Akt–FOXO3a axis expanded its role from membrane trafficking scaffold to a regulator of growth and survival signaling.

    Evidence siRNA knockdown in breast cancer cells, Western blot for Akt/FOXO3a targets, in vivo xenograft

    PMID:21447726

    Open questions at the time
    • Direct mechanism by which FLOT1 activates Akt was not identified
    • Not confirmed in non-cancer primary cells
  7. 2017 High

    Mapping the FLOT1–syndecan-1 interaction to the N-terminal hydrophobic domain and showing that in vivo FLOT1 re-expression normalizes plasma triglycerides demonstrated a physiological role for flotillin-mediated endocytosis in lipoprotein metabolism.

    Evidence Co-immunoprecipitation with domain-deletion mutants, siRNA knockdown, adenoviral rescue with WT vs. ΔN-FLOT1 in diabetic mice

    PMID:29162604

    Open questions at the time
    • Whether FLOT1 directly contacts lipoprotein particles or acts solely via SDC1 remains unclear
    • Structural details of the N-terminal hydrophobic domain interaction undefined
  8. 2023 Medium

    Multiple 2023 studies extended FLOT1's signaling roles: FLOT1 phosphorylates BCAR1 to drive ERK-dependent gastric cancer progression, participates in an SDC1–TGM2–FLOT1–BHMT complex for autophagosome–lysosome fusion in glioblastoma, acts downstream of EIF4A3 to relay PI3K–AKT signaling in lung adenocarcinoma, and regulates apoptosis/pyroptosis in AML cells.

    Evidence Co-IP with phospho-site mutant rescue and ERK inhibitor (gastric cancer); mRFP-GFP-LC3 flux assay and TEM (GBM autophagy); MS-confirmed interaction and epistasis rescue (LUAD); KD/OE with xenograft (AML)

    PMID:36697954 PMID:37011005 PMID:37441590 PMID:37928269

    Open questions at the time
    • Kinase that phosphorylates BCAR1 downstream of FLOT1 not identified
    • Stoichiometry and assembly order of the SDC1–TGM2–FLOT1–BHMT complex not established
    • Most cancer studies from single laboratories and lack independent replication
  9. 2025 Medium

    Demonstrating that FLOT1 promotes M2 macrophage polarization, PD-L1 upregulation, and ferroptosis resistance by maintaining GSH:GSSG balance extended FLOT1 function to immune-cell regulation and redox homeostasis.

    Evidence ChIP for SMARCC1 on FLOT1 promoter, GSH/GSSG ratio measurement, lipid peroxidation assay, co-culture and xenograft models

    PMID:40108025

    Open questions at the time
    • Direct molecular mechanism linking FLOT1 to GSH metabolism is unknown
    • Single laboratory; not replicated
  10. 2026 Medium

    Two 2026 studies revealed tissue-specific FLOT1 functions: interaction with FOSL2 driving EphA2/p38-MAPK–dependent pro-inflammatory microglial polarization in Alzheimer's disease, and localization to circular dorsal ruffles in podocytes to support macropinosome-dependent mTORC1 activation.

    Evidence Co-IP and ChIP for FOSL2–EphA2, Morris water maze in APP/PS1 mice (AD); Flot1 KO podocytes with macropinosome and mTORC1 assays

    PMID:41500583 PMID:41548752

    Open questions at the time
    • How FLOT1 recruits or stabilizes FOSL2 mechanistically is undefined
    • Whether the macropinosome–mTORC1 axis is specific to podocytes or general has not been tested
    • Both findings from single laboratories

Open questions

Synthesis pass · forward-looking unresolved questions
  • A high-resolution structural model of the FLOT1–FLOT2 oligomeric scaffold, the identity of cargo-selectivity determinants, and the direct mechanism linking FLOT1 to Akt and mTOR activation remain unresolved.
  • No crystal or cryo-EM structure of FLOT1 or the FLOT1–FLOT2 complex
  • Cargo selectivity rules for flotillin-mediated endocytosis not determined
  • Direct kinase/effector connecting FLOT1 scaffolding to Akt phosphorylation unknown

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0008289 lipid binding 3 GO:0060090 molecular adaptor activity 3 GO:0005198 structural molecule activity 2
Localization
GO:0005886 plasma membrane 6 GO:0031410 cytoplasmic vesicle 4 GO:0005764 lysosome 2 GO:0005829 cytosol 1
Pathway
R-HSA-162582 Signal Transduction 5 R-HSA-5653656 Vesicle-mediated transport 4 R-HSA-168256 Immune System 2 R-HSA-5357801 Programmed Cell Death 2 R-HSA-9612973 Autophagy 2
Partners
BCAR1CBLEIF4A3FLOT2FOSL2SDC1SORBS1TGM2
Complex memberships
CAP-Cbl-FLOT1 ternary complexFLOT1-FLOT2 oligomeric scaffoldSDC1-TGM2-FLOT1-BHMT complex

Evidence

Reading pass · 16 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1997 Flotillin-1 was identified and molecularly cloned as a resident integral membrane protein component of caveolae, localizing to the Triton-insoluble, buoyant membrane fraction (lipid rafts) in brain and other tissues, and was shown to define a novel family of caveolae-associated integral membrane proteins together with epidermal surface antigen (flotillin-2). Molecular cloning, detergent-resistant membrane fractionation, multiple independent biochemical methods confirming caveolar localization The Journal of biological chemistry High 9153235
2000 Flotillin-1 was identified as forming a ternary complex with CAP (c-Cbl-associated protein) and Cbl, directing the localization of the CAP-Cbl complex to a lipid raft subdomain of the plasma membrane upon insulin stimulation; this pathway was shown to be essential for insulin-stimulated glucose transport independent of PI3K signaling. Yeast two-hybrid screen, co-immunoprecipitation, dominant-negative overexpression in 3T3-L1 adipocytes, glucose transport assay Nature High 11001060
2001 Flotillin-1 was identified as a major integral protein of human erythrocyte lipid rafts, forming independently organized high-order oligomers that act as separate scaffolding components at the cytoplasmic face of erythrocyte lipid rafts. Lipid raft isolation from human erythrocytes, protein identification, sucrose gradient fractionation, oligomer characterization Blood High 11159550
2005 Flotillin-1 defines a clathrin-independent endocytic pathway in mammalian cells: it resides in punctate plasma membrane structures distinct from clathrin-coated pits and caveolin-1-positive caveolae, accumulates GPI-linked proteins and cholera toxin B subunit in endocytic intermediates, and siRNA knockdown inhibits clathrin-independent uptake of cholera toxin and GPI-linked protein endocytosis. Ferro-fluid-based endosome purification, total internal reflection microscopy, immuno-electron microscopy, siRNA knockdown, endocytosis assays Nature cell biology High 16341206
2007 Coassembly of flotillin-1 and flotillin-2 is sufficient to generate de novo membrane microdomains distinct from caveolin-1-positive caveolae; this coassembly induces membrane curvature, formation of plasma-membrane invaginations, and accumulation of intracellular vesicles, establishing flotillin-1 as a defining structural component of a clathrin-independent endocytic machinery. Overexpression of flotillin constructs, live-cell imaging, electron microscopy, membrane curvature and vesicle budding assays Current biology : CB High 17600709
2011 Silencing FLOT1 in breast cancer cells inhibited proliferation and tumorigenicity both in vitro and in vivo, mechanistically associated with suppression of Akt activity, enhanced transcriptional activity of FOXO3a, upregulation of p21(Cip1) and p27(Kip1), and downregulation of cyclin D1. siRNA knockdown, Western blotting, luciferase reporter assay, in vitro proliferation assays, in vivo xenograft Clinical cancer research Medium 21447726
2017 FLOT1 interacts with syndecan-1 (but not caveolin-1) in liver cells via the transmembrane/cytoplasmic region of syndecan-1 and the N-terminal hydrophobic domain of FLOT1; C-TRL binding to syndecan-1 enhances this association and the two proteins traffic together into lysosomes; FLOT1 knockdown substantially inhibits syndecan-1 endocytosis; adenoviral restoration of wild-type but not N-terminal hydrophobic domain-deleted FLOT1 in diabetic mice normalized plasma triglycerides. Co-immunoprecipitation, domain deletion mutants, siRNA knockdown, adenoviral overexpression in mouse model, plasma triglyceride assay Arteriosclerosis, thrombosis, and vascular biology High 29162604
2019 FLOT1 promotes lung adenocarcinoma cell growth, invasion, and migration, inhibits apoptosis, induces epithelial-mesenchymal transition, and modulates the cell cycle by activating the Erk/Akt signaling pathway. Lentiviral knockdown and overexpression, cell growth/invasion/migration assays, apoptosis assay, EMT marker analysis, Erk/Akt pathway analysis Thoracic cancer Medium 30838797
2023 FLOT1 promotes gastric cancer progression and metastasis by physically interacting with BCAR1, regulating BCAR1 phosphorylation and translocation; BCAR1 knockdown blocks FLOT1-induced proliferation/migration/invasion; re-expression of wild-type but not BCAR1(Y410F) partially restores FLOT1-knockdown phenotypes, and this restoration is blocked by ERK inhibitor, placing FLOT1 upstream of BCAR1 phosphorylation and ERK signaling. Co-immunoprecipitation, overexpression/knockdown, BCAR1 phosphorylation-site mutant (Y410F), ERK inhibitor, proliferation/migration/invasion assays International journal of biological sciences Medium 37928269
2023 After irradiation, FLOT1 forms part of a SDC1-TGM2-FLOT1-BHMT complex that mediates autophagosome-lysosome fusion in GBM cells: SDC1 carries TGM2 from the cell membrane into the cytoplasm and transports it to lysosomes by binding to FLOT1, then TGM2 recognizes BHMT on autophagosomes to coordinate their encounter with lysosomes, maintaining autophagic flux and enhancing radioresistance. Co-immunoprecipitation, immunofluorescence, mRFP-GFP-LC3 assay, transmission electron microscopy, flow cytometry, Western blotting, qPCR Theranostics Medium 37441590
2023 EIF4A3 physically interacts with FLOT1 in lung adenocarcinoma cells and positively regulates FLOT1 protein expression; FLOT1 knockdown reverses the increase in cell proliferation and migration caused by EIF4A3 overexpression and rescues EIF4A3-driven activation of the PI3K-AKT-ERK1/2-P70S6K signaling pathway and PI3K class III-mediated autophagy. Mass spectrometry (co-IP pull-down), transcriptome sequencing, siRNA knockdown, overexpression, cell proliferation/migration assays, pathway analysis by Western blot Molecular cancer research : MCR Medium 37011005
2023 FLOT1 knockdown in AML cells triggers both apoptosis and pyroptosis, inhibits tumor engraftment in vivo, while FLOT1 overexpression promotes AML cell growth and apoptosis resistance, demonstrating a role for FLOT1 in regulating cell death pathways in hematological malignancy. siRNA knockdown, overexpression, flow cytometry, in vivo xenograft engraftment assay, Western blotting Annals of hematology Medium 36697954
2025 SMARCC1 activates FLOT1 transcription by binding to its promoter; FLOT1 promotes M2 macrophage polarization, increases PD-L1 expression, and reduces ferroptosis in macrophages by restoring GSH:GSSG ratio and preventing lipid peroxidation; FLOT1 overexpression rescues the inhibitory effects of SMARCC1 knockdown on M2 macrophage infiltration and ferroptosis suppression. ChIP assay (SMARCC1 binding to FLOT1 promoter), siRNA knockdown, overexpression, GSH/GSSG ratio measurement, lipid peroxidation assay, transmission electron microscopy of mitochondria, co-culture assays, xenograft models Journal of molecular medicine (Berlin, Germany) Medium 40108025
2026 In Alzheimer's disease models, FLOT1 interacts with the transcription factor FOSL2, which upregulates EphA2 expression, leading to activation of the p38/MAPK signaling pathway and pro-inflammatory polarization of microglia; silencing FLOT1 in APP/PS1 mice reduced neuroinflammatory markers, prevented pro-inflammatory microglial polarization, and improved spatial memory. Co-immunoprecipitation (FLOT1-FOSL2 interaction), ChIP assay (FOSL2 on EphA2 promoter), dual-luciferase assay, qPCR, Western blotting, IHC, Morris water maze in APP/PS1 mice Neuropharmacology Medium 41548752
2026 Flotillin-1 (Flot1) localizes to circular dorsal ruffles (CDRs) in podocytes; Flot1 depletion reduces macropinosome formation and impairs growth-factor-stimulated mTORC1 activation, demonstrating that Flot1 participates in CDR-derived macropinosome formation and macropinosome-dependent nutrient delivery to lysosomes for mTORC1 activation. Imaging analysis (Flot1 localization at CDRs), Flot1 knockout cells, macropinosome formation assay, mTORC1 activation biochemical assay, growth assay, immunostaining Cell structure and function Medium 41500583
2020 FLOT1 mRNA is regulated by N6-methyladenosine (m6A) modification in ovarian cancer cells; the level of m6A modification of FLOT1 mRNA is significantly elevated in OC cells compared with normal cells, leading to increased FLOT1 mRNA expression; application of the methylation inhibitor 3-deazaadenosine decreased FLOT1 mRNA expression and suppressed tumor formation in a xenograft model. m6A modification analysis, methylation inhibitor treatment, qRT-PCR, xenograft mouse model Cell biology international Low 40066501

Source papers

Stage 0 corpus · 54 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2005 A human protein-protein interaction network: a resource for annotating the proteome. Cell 1704 16169070
2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America 1479 12477932
2017 Architecture of the human interactome defines protein communities and disease networks. Nature 1085 28514442
2015 A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell 1015 26496610
2020 A reference map of the human binary protein interactome. Nature 849 32296183
2021 Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Cell 705 33961781
2012 A census of human soluble protein complexes. Cell 689 22939629
2011 Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Briefings in bioinformatics 656 21873635
2008 Large-scale proteomics and phosphoproteomics of urinary exosomes. Journal of the American Society of Nephrology : JASN 607 19056867
2011 Global landscape of HIV-human protein complexes. Nature 593 22190034
2000 CAP defines a second signalling pathway required for insulin-stimulated glucose transport. Nature 536 11001060
1997 Flotillin and epidermal surface antigen define a new family of caveolae-associated integral membrane proteins. The Journal of biological chemistry 496 9153235
1994 Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. Gene 492 8125298
2011 Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Nature cell biology 490 21423176
2005 Flotillin-1 defines a clathrin-independent endocytic pathway in mammalian cells. Nature cell biology 442 16341206
2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome research 438 15489334
2015 A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. Cell 433 26638075
2022 OpenCell: Endogenous tagging for the cartography of human cellular organization. Science (New York, N.Y.) 432 35271311
2010 Systematic analysis of human protein complexes identifies chromosome segregation proteins. Science (New York, N.Y.) 421 20360068
2021 A proximity-dependent biotinylation map of a human cell. Nature 339 34079125
2016 Identification of Zika Virus and Dengue Virus Dependency Factors using Functional Genomics. Cell reports 306 27342126
2001 Stomatin, flotillin-1, and flotillin-2 are major integral proteins of erythrocyte lipid rafts. Blood 285 11159550
2002 Proteomic analysis of a detergent-resistant membrane skeleton from neutrophil plasma membranes. The Journal of biological chemistry 249 12202484
2010 MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunology and cell biology 221 20458337
2014 Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. Journal of proteomics 215 25281560
2011 Toward an understanding of the protein interaction network of the human liver. Molecular systems biology 207 21988832
2009 Proteomic analysis of integrin-associated complexes identifies RCC2 as a dual regulator of Rac1 and Arf6. Science signaling 207 19738201
2007 Coassembly of flotillins induces formation of membrane microdomains, membrane curvature, and vesicle budding. Current biology : CB 202 17600709
2018 An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations. Nature communications 201 29568061
2020 Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions. Nature cell biology 194 32203420
2012 A membrane microdomain-associated protein, Arabidopsis Flot1, is involved in a clathrin-independent endocytic pathway and is required for seedling development. The Plant cell 154 22589463
2011 Knockdown of FLOT1 impairs cell proliferation and tumorigenicity in breast cancer through upregulation of FOXO3a. Clinical cancer research : an official journal of the American Association for Cancer Research 106 21447726
2015 miRNA-target network reveals miR-124as a key miRNA contributing to clear cell renal cell carcinoma aggressive behaviour by targeting CAV1 and FLOT1. Oncotarget 72 26002553
2015 MiR-506 is down-regulated in clear cell renal cell carcinoma and inhibits cell growth and metastasis via targeting FLOT1. PloS one 56 25793370
2019 Integration of GWAS and brain eQTL identifies FLOT1 as a risk gene for major depressive disorder. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 34 30771789
2023 SDC1-TGM2-FLOT1-BHMT complex determines radiosensitivity of glioblastoma by influencing the fusion of autophagosomes with lysosomes. Theranostics 32 37441590
2019 HOTAIR/miR-214-3p/FLOT1 axis plays an essential role in the proliferation, migration, and invasion of hepatocellular carcinoma. International journal of clinical and experimental pathology 29 31933720
2017 The dynamics and endocytosis of Flot1 protein in response to flg22 in Arabidopsis. Journal of plant physiology 29 28582732
2020 Long Non-Coding RNA TUG1 Promotes Cell Proliferation and Inhibits Cell Apoptosis, Autophagy in Clear Cell Renal Cell Carcinoma via MiR-31-5p/FLOT1 Axis. OncoTargets and therapy 24 32606796
2023 The roles of FLOT1 in human diseases (Review). Molecular medicine reports 23 37772385
2017 Suppression of Hepatic FLOT1 (Flotillin-1) by Type 2 Diabetes Mellitus Impairs the Disposal of Remnant Lipoproteins via Syndecan-1. Arteriosclerosis, thrombosis, and vascular biology 23 29162604
2019 FLOT1 promotes tumor development, induces epithelial-mesenchymal transition, and modulates the cell cycle by regulating the Erk/Akt signaling pathway in lung adenocarcinoma. Thoracic cancer 22 30838797
2023 FLOT1 promotes gastric cancer progression and metastasis through BCAR1/ERK signaling. International journal of biological sciences 15 37928269
2020 Dynamics and Endocytosis of Flot1 in Arabidopsis Require CPI1 Function. International journal of molecular sciences 14 32106431
2020 MiR-1294 acts as a tumor inhibitor in cervical cancer by regulating FLOT1 expression. Journal of biological regulators and homeostatic agents 14 32329296
2023 EIF4A3 Acts on the PI3K-AKT-ERK1/2-P70S6K Pathway through FLOT1 to Influence the Development of Lung Adenocarcinoma. Molecular cancer research : MCR 12 37011005
2021 Long non-coding RNA A1BG-AS1 promotes tumorigenesis in breast cancer by sponging microRNA-485-5p and consequently increasing expression of FLOT1 expression. Human cell 12 34115333
2023 FLOT1 knockdown inhibits growth of AML cells through triggering apoptosis and pyroptosis. Annals of hematology 8 36697954
2025 SMARCC1 promotes M2 macrophage polarization and reduces ferroptosis in lung cancer by activating FLOT1 transcription. Journal of molecular medicine (Berlin, Germany) 5 40108025
2025 FLOT1 Is a Novel Serum Biomarker of Ovarian Cancer Targeted by N6-methyladenosine Modification Inhibition. Cell biology international 4 40066501
2024 Circ_0003855 involvement of esophageal cancer progression through miR-622/FLOT1. Oncology research 2 38686057
2026 Depletion of Flot1 attenuates macropinosome-dependent mTORC1 activation in podocytes. Cell structure and function 0 41500583
2026 The interaction between FLOT1 and FOSL2 promotes EphA2 transcription, regulating microglial polarization and affecting neuroinflammation in Alzheimer's disease. Neuropharmacology 0 41548752
2025 Luteolin suppresses cell migration and invasion via targeting miR-6809-5p/FLOT1/FAK and eliciting EMT in hepatocellular carcinoma. Translational oncology 0 40857906