Affinage

EXOC3

Exocyst complex component 3 · UniProt O60645

Length
745 aa
Mass
85.6 kDa
Annotated
2026-06-09
38 papers in source corpus 27 papers cited in narrative 27 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 8/8 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

EXOC3/Sec6 is a core subunit of the octameric exocyst, a multisubunit tethering complex that directs secretory vesicle delivery and fusion at the plasma membrane (PMID:1523887, PMID:7615633). First defined in budding yeast as a soluble ~85 kDa protein required for fusion of post-Golgi vesicles, Sec6 is a stable component of the ~1–2 MDa Sec6/8/15 complex that localizes to sites of active exocytosis (PMID:1523887, PMID:7615633). In mammalian cells the complex cycles between a cytosolic pool and membrane-recruited states, residing on both the trans-Golgi network and plasma membrane and being required for multiple steps of TGN-to-plasma-membrane exocytic transport (PMID:11696560). In polarized epithelia, calcium-dependent cell-cell adhesion recruits the complex to lateral contacts in association with E-cadherin and nectin-2α and tight junction proteins, a localization sufficient to direct basolateral surface biogenesis (PMID:9630218, PMID:14709721). Mechanistically, Sec6 couples tethering to SNARE-mediated fusion: it directly and mutually exclusively binds the plasma membrane SNARE Sec9 and the Sec1/Munc18 SM protein Sec1, binds binary and ternary Sso1-Sec9-Snc2 SNARE complexes, and engages the exocyst itself in a manner incompatible with Sec9 binding, supporting a sequential hand-off model upon vesicle arrival (PMID:22114349, PMID:26446795). The complex is regulated by the small GTPase RalA, which binds the Sec5 and Exo84 subunits competitively through overlapping switch-region interfaces to control complex assembly (PMID:12839989, PMID:15920473). Beyond canonical secretion, EXOC3 supports developmental and physiological trafficking demonstrated genetically across systems: it acts as a Rab11-recycling-endosome effector for apical and adherens-junction cargo delivery in Drosophila (PMID:15897260, PMID:16224820), is required for platelet granule secretion, integrin activation and GPVI signaling with consequences for thrombosis and hemostasis (PMID:33560379), and acts upstream of vimentin to control triacylglycerol/lipid-droplet biosynthesis during stem cell differentiation (PMID:33300287). EXOC3 also negatively regulates innate antiviral immunity by promoting selective-autophagy receptor–mediated degradation of the adaptors STING (via NDP52) and MAVS (via P62) (PMID:41406560, PMID:40780029).

Mechanistic history

Synthesis pass · year-by-year structured walk · 11 steps
  1. 1992 High

    Established that Sec6 is a discrete gene product essential for the terminal step of secretion, answering whether post-Golgi vesicle fusion at the plasma membrane requires a dedicated soluble factor.

    Evidence Gene cloning by complementation, fractionation, and synthetic lethality with sec8 in S. cerevisiae

    PMID:1523887

    Open questions at the time
    • No biochemical complex defined
    • No molecular partners or mechanism of action identified
  2. 1995 High

    Defined Sec6 as a stable subunit of a large multiprotein assembly localized to exocytic sites, transforming it from an isolated gene into a complex component.

    Evidence Affinity chromatography, gel filtration, sucrose gradients, co-IP, and immunofluorescence in yeast

    PMID:7615633

    Open questions at the time
    • Subunit stoichiometry and architecture unresolved
    • Direct molecular activity of Sec6 within the complex unknown
  3. 2000 High

    Extended exocyst function to mammalian polarized trafficking and signaling-organelle scaffolding, showing the complex is recruited to membrane domains and links to adhesion and Ca2+ machinery.

    Evidence Permeabilized-cell antibody inhibition with cargo readouts in MDCK cells; reciprocal co-IP and Ca2+ assays in pancreatic acinar cells

    PMID:10973998 PMID:9630218

    Open questions at the time
    • Which subunit mediates membrane recruitment not resolved
    • Ca2+-protein associations are correlative, mechanism indirect
  4. 2001 High

    Mapped exocyst itinerary and intra-complex interactions, showing the complex functions at both TGN and plasma membrane steps of exocytosis.

    Evidence Semiintact-cell antibody inhibition with pharmacology in NRK cells; yeast two-hybrid mapping of human subunit contacts

    PMID:11493706 PMID:11696560

    Open questions at the time
    • Sec6-specific contribution to each step not isolated
    • GFP-subunit assembly failures leave human complex architecture unclear
  5. 2004 Medium

    Identified the molecular cue specifying exocyst localization in epithelia, answering how the complex finds lateral membrane domains.

    Evidence Co-IP with surface-labeled E-cadherin/nectin-2α and reconstitution in fibroblasts (MDCK system)

    PMID:14709721

    Open questions at the time
    • Direct vs indirect binding to cadherin/nectin not distinguished
    • Subunit responsible for adhesion-complex contact unknown
  6. 2005 High

    Provided structural and genetic mechanism for GTPase regulation and developmental cargo trafficking, establishing RalA as a competitive regulator and the exocyst as a Rab11 effector.

    Evidence Crystallography of Exo84-RalA with competition assays; Drosophila sec6 loss-of-function with cargo trafficking phenotypes and co-IP

    PMID:15897260 PMID:15920473 PMID:16224820

    Open questions at the time
    • RalA regulation maps to Sec5/Exo84, not Sec6 directly
    • How Rab11 endosome trafficking integrates with SNARE fusion unresolved
  7. 2015 High

    Resolved how Sec6 couples tethering to fusion machinery, showing direct, mutually exclusive binding to SNARE and SM proteins that orders assembly events.

    Evidence In vitro binding/SNARE-assembly kinetics, cross-linking MS, and mutagenesis with yeast growth validation

    PMID:22114349 PMID:26446795

    Open questions at the time
    • Sequential hand-off model not directly visualized on vesicles
    • Conservation of Sec6-SM/SNARE coupling in mammals not demonstrated
  8. 2019 Medium

    Demonstrated a vesicle-vesicle fusion role at cytoskeletal sites independent of delivery, broadening Sec6 function beyond plasma-membrane tethering.

    Evidence Live imaging, gene silencing, and co-IP with KEULE in Physcomitrella patens phragmoplast

    PMID:30635445

    Open questions at the time
    • Plant-ortholog finding; mammalian relevance untested
    • Mechanism of microtubule-overlap targeting unknown
  9. 2021 High

    Established a physiological secretory requirement in mammals in vivo, showing EXOC3 is essential for platelet granule secretion and receptor signaling with thrombotic consequences.

    Evidence Conditional knockout mice with aggregometry, secretion assays, signaling readouts, and in vivo thrombosis/bleeding models

    PMID:33560379

    Open questions at the time
    • Whether defects reflect canonical exocyst tethering or additional roles not dissected
    • Mechanism of paradoxical PAR4 enhancement only partially explained
  10. 2020 Medium

    Linked EXOC3 to lipid metabolism in differentiation, placing it upstream of vimentin in controlling TAG/lipid-droplet biosynthesis.

    Evidence Genetic knockout/knockdown, lipidomics, epistasis, and palmitic acid rescue in mouse ESCs and planarians

    PMID:33300287

    Open questions at the time
    • Molecular link between exocyst tethering and lipid synthesis not defined
    • Whether function requires exocyst complex unknown
  11. 2025 Medium

    Identified a function in innate immune suppression, showing EXOC3 promotes selective autophagic degradation of antiviral adaptors.

    Evidence Overexpression/knockdown, co-IP, autophagic flux, IFN reporters, and viral replication assays with NDP52/P62 epistasis in bovine cells

    PMID:40780029 PMID:41406560

    Open questions at the time
    • Single-lab, bovine cell models
    • Whether degradation requires the intact exocyst complex untested
    • Direct vs scaffold role in receptor-adaptor recruitment unresolved

Open questions

Synthesis pass · forward-looking unresolved questions
  • How EXOC3 mechanistically bridges its canonical exocyst tethering/SNARE-coupling activity with the diverse signaling, metabolic, and autophagy phenotypes attributed to it in mammalian systems remains unresolved.
  • No high-resolution structure of human Sec6 or the assembled human exocyst
  • Whether non-secretory roles depend on the intact complex untested
  • Direct binding partners for mammalian signaling/autophagy functions not biochemically defined

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0005198 structural molecule activity 2 GO:0060090 molecular adaptor activity 2
Localization
GO:0005829 cytosol 3 GO:0005886 plasma membrane 3 GO:0005794 Golgi apparatus 1
Pathway
R-HSA-5653656 Vesicle-mediated transport 3 R-HSA-9609507 Protein localization 2
Partners
CDH1EXOC4EXOC6NDP52RAB11RALASEC1SEC9
Complex memberships
exocyst (Sec6/8/15 complex)

Evidence

Reading pass · 27 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1992 SEC6 encodes an 85 kDa predominantly soluble protein that sediments at 14S and is required for fusion of post-Golgi vesicles with the plasma membrane in S. cerevisiae; sec6-4 displays synthetic lethality with sec8-9, indicating inter-related functions between the two gene products. Gene cloning by complementation, subcellular fractionation, gene disruption, synthetic lethality analysis Yeast High 1523887
1995 Sec6 is a stable component of the yeast Sec6/8/15 multisubunit complex (~1-2 MDa); Sec6 co-fractionates with Sec8/15 by metal-affinity chromatography, gel filtration, and sucrose velocity centrifugation, and coimmunoprecipitates with c-myc-tagged Sec8. The complex is disrupted in sec3-2, sec5-24, and sec10-2 backgrounds. Sec8 localizes to small bud tips, placing the complex at sites of exocytosis. Immobilized metal affinity chromatography, gel filtration, sucrose velocity centrifugation, immunoprecipitation, immunofluorescence localization The Journal of cell biology High 7615633
1998 In mammalian epithelial (MDCK) cells, the Sec6/8 complex resides in a cytosolic ~17S complex; upon calcium-dependent cell-cell adhesion, ~70% of Sec6/8 is recruited to sites of cell-cell contact. Sec8 antibodies in permeabilized cells inhibit delivery of LDL receptor to the basal-lateral membrane but not p75NTR to the apical membrane, demonstrating that lateral membrane recruitment of the Sec6/8 complex is essential for biogenesis of epithelial cell surface polarity. Sucrose gradient sedimentation, streptolysin-O permeabilization with antibody inhibition, immunofluorescence Cell High 9630218
1998 The rat brain sec6/8 complex coimmunoprecipitates with a filament composed of four mammalian septins (including CDC10), suggesting a physical interaction between the exocyst and septin filaments. Electron microscopy of glutaraldehyde-fixed rat brain sec6/8 complex reveals a T- or Y-shaped conformation. Co-immunoprecipitation, electron microscopy, sucrose gradient fractionation Neuron Medium 9655500
2001 Sec6/8 complex is present on both the trans-Golgi network (TGN) and plasma membrane in NRK cells, colocalizing with exocytic cargo VSVG-tsO45. Brefeldin A blocks Sec6/8 recruitment to the plasma membrane; expression of kinase-inactive protein kinase D or low-temperature incubation causes Sec6/8 accumulation on TGN. Antibodies against TGN-bound or plasma membrane-bound Sec6/8 added to semiintact cells cause cargo accumulation in respective compartments, indicating Sec6/8 is required for multiple steps of TGN-to-plasma membrane exocytic transport. Immunofluorescence colocalization, semiintact cell functional assays with specific antibody inhibition, pharmacological treatments The Journal of cell biology High 11696560
2001 Human Sec3 (hSec3) interacts with Sec5 and Sec8 subunits of the mammalian Sec6/8 complex in the yeast two-hybrid system. GFP-fusions of most subunits fail to assemble into complex with endogenous proteins and are cytosolic when expressed in MDCK cells; only GFP-Exo70 localizes to lateral membrane, and its overexpression disrupts tight monolayer formation. Yeast two-hybrid, GFP fusion expression and imaging in MDCK cells Proceedings of the National Academy of Sciences of the United States of America Medium 11493706
2000 Sec6/8 complex associates with Ca2+ signaling proteins at the apical pole of pancreatic acinar cells. Immunoprecipitation of Sec8 co-precipitates Sec6, IP3R3, Gβγ, plasma membrane Ca2+ pump, Gαq, PLCβ1, and IP3R1. This interaction is mediated by the actin cytoskeleton, as actin filament disruption dissociates Sec6/8 from Ca2+ signaling proteins. Anti-Sec6/8 antibodies inhibit Ca2+ signaling upstream of Ca2+ release by IP3; actin disruption by latrunculin B partially translocates Sec6/8 to cytosol and interferes with Ca2+ wave propagation. Immunoprecipitation, confocal immunolocalization, pharmacological actin disruption, functional Ca2+ signaling assays The Journal of cell biology Medium 10973998
2003 Crystal structure of the Sec5 Ral-binding domain in complex with RalA·GppNHp at 2.1 Å resolution shows that Sec5 folds into an immunoglobulin-like β-sandwich and interacts with RalA via a continuous antiparallel β-sheet involving both switch regions. Sec5 Thr11 and Arg27, and RalA Glu38 are required for complex formation (validated by isothermal titration calorimetry). This establishes the structural basis for GTP-dependent RalA binding to the Sec6/8 complex via the Sec5 subunit. X-ray crystallography (2.1 Å), isothermal titration calorimetry, site-directed mutagenesis The EMBO journal High 12839989
2004 In polarized MDCK epithelial cells, the Sec6/8 complex is recruited to cell-cell contacts in a high molecular mass complex with tight junction proteins and a portion of E-cadherin. Sec6/8 co-immunoprecipitates with cell surface-labeled E-cadherin and nectin-2α. Co-expression of E-cadherin and nectin-2α in fibroblasts is sufficient to recruit Sec6/8 to cell-cell contacts, indicating that adhesion complexes specify Sec6/8 localization. Co-immunoprecipitation, sucrose gradient fractionation, GFP overexpression in fibroblasts, immunofluorescence Journal of cell science Medium 14709721
2005 Crystal structure of the Exo84 Ral-binding domain in complex with active RalA shows the domain adopts a pleckstrin homology fold. Structural and biochemical data demonstrate that Exo84 and Sec5 competitively bind active RalA via an overlapping interface including both switch regions; key binding residues were confirmed by mutagenesis. This establishes that RalA regulates Sec6/8 complex assembly through competitive effector binding. X-ray crystallography, site-directed mutagenesis, binding assays The EMBO journal High 15920473
2005 In Drosophila photoreceptor cells (PRCs), loss-of-function sec6 mutations cause cell lethality, disrupt plasma membrane growth, and lead to accumulation of secretory vesicles and failure to transport proteins to the rhabdomere (apical subdomain). Sec6 but not Sec5 or Sec8 shows accumulation at adherens junctions in developing PRCs. Rab11 forms a complex with Sec5, and Sec5 interacts with Sec6, suggesting the exocyst is a Rab11 effector for apical membrane protein transport. Genetic loss-of-function analysis, immunofluorescence localization, co-immunoprecipitation The Journal of cell biology High 15897260
2005 In Drosophila epithelial cells, loss of function of exocyst components sec5, sec6, and sec15 causes DE-Cadherin accumulation in an enlarged Rab11 recycling endosomal compartment and inhibits DE-Cad delivery to the plasma membrane. Rab11 and Armadillo interact with exocyst components Sec15 and Sec10 respectively, placing Sec6-containing exocyst complex at the step of Rab11 recycling endosome-to-membrane trafficking. Genetic loss-of-function, immunofluorescence, co-immunoprecipitation Developmental cell High 16224820
2005 The sec6-4 phenotype in S. cerevisiae is defined by a single point mutation L633P in the SEC6 coding region. At restrictive temperature, Sec6-4p is mislocalized and cells accumulate homogeneous secretory vesicles. At permissive temperature, wild-type Sec6p-GFP localizes to buds and septa, consistent with its role at sites of exocytosis. Site-directed mutagenesis, GFP fusion localization, electron microscopy of vesicle accumulation Gene Medium 16185821
2011 Yeast Sec6 directly binds Sec1 (a Sec1/Munc18 family SM protein) in addition to its known binding partner Sec9 (plasma membrane SNARE). The Sec6-Sec1 interaction is exclusive of Sec6-Sec9 but compatible with Sec6-exocyst assembly. The Sec6-exocyst interaction is incompatible with Sec6-Sec9. This proposes a sequential mechanism whereby vesicle arrival triggers Sec6 to release Sec9, assemble into exocyst, and recruit Sec1 for coordinated SNARE complex formation. In vitro binding assays, co-immunoprecipitation, yeast genetics Molecular biology of the cell High 22114349
2015 S. cerevisiae Sec6 binds both the binary Sso1-Sec9 and ternary Sso1-Sec9-Snc2 SNARE complexes; it does not change the rate of SNARE assembly (contrary to previous hypothesis that it inhibits assembly). Cross-linking/mass spectrometry identified specific residues required for Sec6-Sec9 binding; mutation of these residues causes a yeast growth defect. In vitro SNARE assembly kinetic assays, cross-linking mass spectrometry, site-directed mutagenesis, yeast growth assays The Journal of biological chemistry High 26446795
2012 Sec6 knockdown in HSC3 oral cancer cells increases α-E-catenin expression and causes E-cadherin and β-catenin to localize predominantly at cell-cell contact regions, indicating Sec6 negatively regulates cell-cell adhesion complex organization. siRNA knockdown, immunofluorescence, western blot FEBS letters Low 22381337
2014 Sec6 regulates cytoplasmic translocation and degradation of p27 via interactions with Jab1/CSN5 and Siah1; Sec6 promotes p27 phosphorylation at Thr157, facilitating cytoplasmic localization and subsequent degradation, thereby suppressing cell cycle progression. siRNA knockdown, co-immunoprecipitation, phosphorylation analysis, cell cycle assays Cellular signalling Medium 24949832
2015 Perturbation of exocyst components including Sec6/8 results in resistance to ionizing radiation and accelerated resolution of DNA damage, but with accumulation of aberrant chromatid exchanges. Sec8 perturbation leads to accumulation of ATF2, RNF20, and DDR-associated chromatin marks, and Rad51 repairosomes, indicating exocyst supports DNA repair fidelity. siRNA knockdown, irradiation survival assays, chromatin immunoprecipitation, recombination frequency measurement Molecular and cellular biology Medium 26283729
2016 Sec6 knockdown inhibits IκBα degradation, delays nuclear translocation of p65, and reduces NF-κB transcriptional activity in TNF-α-stimulated HeLa cells. Mechanistically, Sec6 knockdown decreases expression of p90RSKs and phosphorylation of ERK, p90RSK1 (Ser380), and IκBα (Ser32). siRNA knockdown, western blot for phosphorylation, luciferase transcriptional reporter, immunofluorescence for p65 localization Journal of cellular physiology Medium 26247921
2018 Sec6 knockdown suppresses phosphorylation of p38 MAPK (via MKK3/6), MK2, and HSP27 (at Ser78 and Ser82), and overexpression has the reverse effect. Reduced phospho-HSP27 via Sec6 knockdown suppresses cell migration and promotes apoptosis after TNF-α/cycloheximide treatment. siRNA knockdown, overexpression, western blot for kinase phosphorylation, cell migration assays, apoptosis assays Cellular signalling Medium 29729335
2019 In Physcomitrella patens, exocyst subunit Sec6 (but not Sec3 or Sec5) localizes to microtubule overlap regions in the phragmoplast prior to cell plate membrane arrival. Sec6 physically interacts with KEULE (a Sec1/Munc18 ortholog). Sec6 gene silencing delays recruitment of KEULE and vesicles to the early cell plate, indicating Sec6 promotes vesicle-vesicle fusion at microtubule overlaps independently of vesicle delivery. Live-cell fluorescence microscopy, co-immunoprecipitation, gene silencing, time-lapse imaging Journal of cell science Medium 30635445
2020 Tnfaip2/Exoc3 acts epistatically upstream of vimentin (Vim) in controlling lipid metabolism during stem cell differentiation; Tnfaip2 knockout impairs induction of triacylglycerol synthesis and lipid droplet formation in differentiating ESCs. Knockdown of planarian Smed-exoc3 also causes strong reduction of TAGs. Supplementation with palmitic acid rescues both ESC differentiation and planarian organ maintenance, placing Exoc3 upstream of TAG/lipid droplet biosynthesis required for differentiation. Genetic knockout/knockdown, lipidomics, epistasis analysis, rescue with palmitic acid supplementation EMBO reports Medium 33300287
2021 EXOC3 conditional knockout in mouse megakaryocytes/platelets causes defects in platelet aggregation, integrin activation, α-granule secretion (P-selectin, PF4), dense granule secretion, and lysosomal granule secretion after GPVI agonist stimulation. GPVI surface levels were decreased 14.5% in KO platelets, with defects in proximal GPVI signaling (Syk and LAT phosphorylation) and calcium mobilization. PAR4-stimulated responses were paradoxically enhanced in KO platelets, and suppressed by P2Y12 antagonist, implicating enhanced ADP release. EXOC3 KO mice show accelerated arterial thrombosis and improved hemostasis. Conditional knockout mice, platelet aggregometry, granule secretion assays, flow cytometry, phosphorylation analysis, calcium imaging, in vivo thrombosis model, tail bleeding time Blood advances High 33560379
2023 Two truncated forms of human Sec6 (HuSec6 121-734 and HuSec6 121-745) were expressed, purified (>95% purity), and crystallized; X-ray diffraction yielded ~9 Å resolution crystals, providing initial structural data for human Sec6. Recombinant protein expression in E. coli, X-ray crystallography (9 Å resolution) Studies in health technology and informatics Low 38007759
2024 Male germ cell-specific conditional knockout of Exoc3 (SEC6) in mice does not cause spermatogenesis defects, establishing that EXOC3 is not required for spermatogenesis (negative finding). Conditional knockout mice, histological analysis of spermatogenesis Experimental animals Medium 38325858
2025 Sec6 suppresses innate immune responses to bovine herpesvirus 1 (BoHV-1) by promoting NDP52-mediated autophagic degradation of STING. Mechanistically, Sec6 enhances the physical interaction between NDP52 and STING; NDP52 knockdown abolishes Sec6-mediated IFN-β suppression and Sec6's ability to enhance viral replication. Overexpression/knockdown, co-immunoprecipitation, autophagic flux assays, IFN-β reporter assay, viral replication assay Veterinary microbiology Medium 41406560
2025 Sec6 suppresses BEFV-triggered type I IFN signaling by promoting P62-mediated autophagic degradation of MAVS. Sec6 enhances the P62-MAVS interaction; P62 knockdown abolishes Sec6-mediated IFN-I suppression and viral replication enhancement. Sec6 fails to degrade MAVS in P62-knockdown cells. Overexpression/knockdown, co-immunoprecipitation, autophagic flux assays, IFN-I reporter assay, viral replication assay Veterinary microbiology Medium 40780029

Source papers

Stage 0 corpus · 38 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1998 Sec6/8 complex is recruited to cell-cell contacts and specifies transport vesicle delivery to the basal-lateral membrane in epithelial cells. Cell 434 9630218
1998 Subunit composition, protein interactions, and structures of the mammalian brain sec6/8 complex and septin filaments. Neuron 296 9655500
1995 Sec6, Sec8, and Sec15 are components of a multisubunit complex which localizes to small bud tips in Saccharomyces cerevisiae. The Journal of cell biology 258 7615633
2005 Drosophila exocyst components Sec5, Sec6, and Sec15 regulate DE-Cadherin trafficking from recycling endosomes to the plasma membrane. Developmental cell 231 16224820
2001 Sec6/8 complexes on trans-Golgi network and plasma membrane regulate late stages of exocytosis in mammalian cells. The Journal of cell biology 147 11696560
2004 Mechanism of recruiting Sec6/8 (exocyst) complex to the apical junctional complex during polarization of epithelial cells. Journal of cell science 142 14709721
2008 Sec6-dependent sorting of fungal extracellular exosomes and laccase of Cryptococcus neoformans. Molecular microbiology 129 19210702
1999 Targeting vesicles to specific sites on the plasma membrane: the role of the sec6/8 complex. Trends in cell biology 125 10203793
2005 Exo84 and Sec5 are competitive regulatory Sec6/8 effectors to the RalA GTPase. The EMBO journal 123 15920473
2005 Essential function of Drosophila Sec6 in apical exocytosis of epithelial photoreceptor cells. The Journal of cell biology 101 15897260
2003 Structural basis of the interaction between RalA and Sec5, a subunit of the sec6/8 complex. The EMBO journal 98 12839989
2001 The Sec6/8 complex in mammalian cells: characterization of mammalian Sec3, subunit interactions, and expression of subunits in polarized cells. Proceedings of the National Academy of Sciences of the United States of America 95 11493706
2011 Regulation of exocytosis by the exocyst subunit Sec6 and the SM protein Sec1. Molecular biology of the cell 86 22114349
2000 The mammalian Sec6/8 complex interacts with Ca(2+) signaling complexes and regulates their activity. The Journal of cell biology 81 10973998
2015 The Exocyst Subunit Sec6 Interacts with Assembled Exocytic SNARE Complexes. The Journal of biological chemistry 46 26446795
2003 Sec6 is localized to the plasma membrane of mature synaptic terminals and is transported with secretogranin II-containing vesicles. Neuroscience 31 12763070
1992 SEC6 encodes an 85 kDa soluble protein required for exocytosis in yeast. Yeast (Chichester, England) 31 1523887
2003 Ultracentrifugation-based approaches to study regulation of Sec6/8 (exocyst) complex function during development of epithelial cell polarity. Methods (San Diego, Calif.) 26 12798134
2012 The SEC6 protein is required for contractile vacuole function in Chlamydomonas reinhardtii. Journal of cell science 21 22427688
2018 Sec6 enhances cell migration and suppresses apoptosis by elevating the phosphorylation of p38 MAPK, MK2, and HSP27. Cellular signalling 20 29729335
2016 Nuclear Translocation of p65 is Controlled by Sec6 via the Degradation of IκBα. Journal of cellular physiology 19 26247921
2020 Tnfaip2/exoc3-driven lipid metabolism is essential for stem cell differentiation and organ homeostasis. EMBO reports 17 33300287
2014 Sec6 regulated cytoplasmic translocation and degradation of p27 via interactions with Jab1 and Siah1. Cellular signalling 16 24949832
2012 Knockdown of Sec6 improves cell-cell adhesion by increasing α-E-catenin in oral cancer cells. FEBS letters 16 22381337
2015 Role of the Exocyst Complex Component Sec6/8 in Genomic Stability. Molecular and cellular biology 15 26283729
2005 Characterization of the Saccharomyces cerevisiae sec6-4 mutation and tools to create S. cerevisiae strains containing the sec6-4 allele. Gene 14 16185821
2019 Exocyst subunit Sec6 is positioned by microtubule overlaps in the moss phragmoplast prior to cell plate membrane arrival. Journal of cell science 13 30635445
2016 Sec6/8 regulates Bcl-2 and Mcl-1, but not Bcl-xl, in malignant peripheral nerve sheath tumor cells. Apoptosis : an international journal on programmed cell death 13 26892009
2021 Loss of the exocyst complex component EXOC3 promotes hemostasis and accelerates arterial thrombosis. Blood advances 12 33560379
2008 Involvement of Exoc3l, a protein structurally related to the exocyst subunit Sec6, in insulin secretion. Biomedical research (Tokyo, Japan) 12 18480549
2022 Molecular cloning, inducible expression and function analysis of Epinephelus coioides Sec6 response to SGIV infection. Fish & shellfish immunology 8 35483595
2015 The Candida albicans Exocyst Subunit Sec6 Contributes to Cell Wall Integrity and Is a Determinant of Hyphal Branching. Eukaryotic cell 8 26002719
2021 SEC6 exocyst subunit contributes to multiple steps of growth and development of Physcomitrella (Physcomitrium patens). The Plant journal : for cell and molecular biology 7 33599020
2023 SEC1A and SEC6 synergistically regulate pollen tube polar growth. Journal of integrative plant biology 6 36951316
2025 Sec6 suppresses BoHV-1-triggered innate immunity through NDP52-mediated autophagic degradation of STING. Veterinary microbiology 2 41406560
2025 Sec6 suppresses BEFV-triggered type I IFN responses by promoting P62-mediated MAVS degradation. Veterinary microbiology 1 40780029
2024 Deletion of Exoc7, but not Exoc3, in male germ cells causes severe spermatogenesis failure with spermatocyte aggregation in mice. Experimental animals 1 38325858
2023 Structural Study of the Exocyst Subunit Human Sec6. Studies in health technology and informatics 0 38007759

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