Affinage

EXOC4

Exocyst complex component 4 · UniProt Q96A65

Length
974 aa
Mass
110.5 kDa
Annotated
2026-04-28
28 papers in source corpus 20 papers cited in narrative 20 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

EXOC4 (Sec8) is a core subunit of the octameric exocyst complex that tethers secretory vesicles to the plasma membrane at sites of polarized exocytosis, functioning downstream of Rab GTPases in processes spanning embryonic development, synaptic organization, and myelination (PMID:1512289, PMID:7615633, PMID:9441674, PMID:16478790). Its C-terminal ITTV PDZ-binding motif, separated from the helical core by a structurally critical 14-residue spacer, mediates interactions with synaptic scaffolds such as SAP102 and PSD-95 to direct membrane protein delivery at neuronal junctions (PMID:12675619, PMID:37849738). Beyond vesicle tethering, EXOC4 stabilizes innate immune sensors STING1 and RIG-I by blocking their E3-ligase-mediated ubiquitination and degradation, thereby promoting type I interferon responses to both DNA and RNA viruses (PMID:40413753, PMID:41580425). In the nucleus, p300-mediated acetylation of EXOC4 at K433 drives its nuclear translocation, where it facilitates PRMT5-dependent methylation of KU70 to enhance non-homologous end joining DNA repair (PMID:41826730).

Mechanistic history

Synthesis pass · year-by-year structured walk · 14 steps
  1. 1992 High

    Establishing that Sec8p is a component of a multisubunit particle at the plasma membrane acting downstream of the Rab GTPase Sec4p resolved how secretory vesicles are directed to fusion sites, framing Sec8 as an effector in polarized exocytosis.

    Evidence Fractionation, sucrose gradient sedimentation, gel filtration, cross-linking, and immunoprecipitation in S. cerevisiae

    PMID:1512289

    Open questions at the time
    • Mammalian ortholog function not yet demonstrated
    • Complete subunit composition of the particle unknown
    • Direct vesicle tethering activity not reconstituted
  2. 1995 High

    Defining the exocyst as an ~8-subunit complex localized to sites of active exocytosis, with Sec8 as a core subunit whose incorporation depends on other exocyst members, established the architectural framework of the tethering machinery.

    Evidence Metal affinity chromatography, gel filtration, sucrose sedimentation, co-IP, and immunofluorescence in S. cerevisiae

    PMID:7615633

    Open questions at the time
    • Structure of Sec8 within the complex unknown
    • Stoichiometry and assembly order not defined
  3. 1997 High

    Demonstrating that homozygous Sec8 knockout mouse embryos arrest at the primitive streak stage established that EXOC4 is essential for early mammalian development, likely reflecting a fundamental requirement for polarized membrane trafficking.

    Evidence Gene trap mutagenesis and phenotypic analysis of homozygous mutant mouse embryos

    PMID:9441674

    Open questions at the time
    • Specific cellular process disrupted (membrane delivery vs. signaling) not distinguished
    • Tissue-specific requirements not explored
  4. 2003 Medium

    Identifying that EXOC4 binds PSD-95 via its C-terminal TTV PDZ-binding motif connected exocyst-mediated vesicle delivery to synaptic scaffolding, suggesting a mechanism for targeted receptor/membrane protein insertion at postsynaptic sites.

    Evidence Co-immunoprecipitation from brain tissue, peptide competition, and TTV motif mutagenesis

    PMID:12675619

    Open questions at the time
    • Functional consequence for receptor trafficking at synapses not directly shown
    • Specificity among PDZ-domain partners not resolved
  5. 2005 High

    Showing that Drosophila sec8 null mutants exhibit doubled synaptic microtubule density with mild receptor trafficking defects revealed a role for EXOC4 in cytoskeletal regulation at synapses, beyond canonical vesicle tethering.

    Evidence Null mutant analysis with immunocytochemistry, electrophysiology, and immunoblotting at Drosophila NMJ

    PMID:16351720

    Open questions at the time
    • Mechanism linking exocyst to microtubule regulation unknown
    • Whether this is a direct or indirect effect not established
  6. 2006 Medium

    Demonstrating that EXOC4 interacts with OSP/Claudin11 and CASK in oligodendrocytes and that its knockdown inhibits myelin-like membrane formation extended the exocyst's role to glial cell myelination, later reinforced by the Dlg1-Sec8 interaction in Schwann cells.

    Evidence siRNA knockdown, co-IP, co-fractionation in oligodendrocytes; Dlg1 co-IP and Schwann cell/DRG coculture with Mtmr2-null rescue

    PMID:16478790 PMID:19587293

    Open questions at the time
    • Whether EXOC4's role in myelination is exocyst-dependent or independent not distinguished
    • In vivo myelination phenotype from EXOC4 conditional knockout not shown
  7. 2009 Medium

    Identifying insulin-stimulated PI3K-dependent phosphorylation of EXOC4 at Ser-32 defined a post-translational modification site, although S32A/S32E mutants showed no effect on GLUT4 trafficking, leaving the functional significance unresolved.

    Evidence Phosphoproteomics (MS), wortmannin inhibition, S32A/S32E mutagenesis, surface GLUT4 assay in 3T3-L1 adipocytes

    PMID:19006485

    Open questions at the time
    • Functional role of Ser-32 phosphorylation remains unknown
    • Other trafficking cargoes not tested
    • Whether Akt is the direct kinase not confirmed by in vitro kinase assay
  8. 2014 Low

    Knockdown studies linking EXOC4 to MAPK signaling (via JIP4-MKK4-JNK/p38), cell cycle regulation (via FOXO-p21-Mdm2), and cell migration (via cytokeratin8-FAK) suggested signaling roles beyond vesicle tethering, though these findings rest on single-lab knockdown approaches.

    Evidence siRNA knockdown with co-IP and phosphorylation immunoblotting in cancer cell lines

    PMID:24299491 PMID:25244576 PMID:25725287

    Open questions at the time
    • None confirmed by independent labs
    • Direct vs. indirect effects of exocyst disruption not separated
    • Reliance on siRNA without rescue experiments limits confidence
  9. 2016 Medium

    Identifying CREG1 as a direct EXOC4 interactor required for N-cadherin stabilization at intercalated discs linked the exocyst to adherens junction assembly during cardiomyocyte differentiation.

    Evidence Co-IP, site-directed mutagenesis, CREG1 KO ES cell rescue, immunofluorescence colocalization

    PMID:27334848

    Open questions at the time
    • In vivo cardiac phenotype of EXOC4 loss not shown
    • Whether EXOC4 delivers N-cadherin-containing vesicles or stabilizes junctional complexes not resolved
  10. 2022 Medium

    Showing that EXOC4 promotes FAK Y397 phosphorylation by stimulating secretion of integrin α5/β1 and EGF in gastric cancer provided a mechanistic link between exocyst-mediated secretion and outside-in FAK signaling that drives metastasis.

    Evidence LC-MS/MS proteomics, FAK inhibitor treatment, migration/invasion assays, patient-derived xenograft models

    PMID:35471457

    Open questions at the time
    • Generalizability beyond diffuse-type gastric cancer not tested
    • Whether FAK activation is entirely secondary to secretion not fully excluded
  11. 2023 High

    The 2.5 Å crystal structure of the C-terminal half of EXOC4 revealed an unusually long C-terminal helix with a 14-residue spacer essential for SAP102 PDZ2 binding, providing the first structural basis for how the exocyst engages synaptic PDZ scaffolds.

    Evidence X-ray crystallography, deletion mutagenesis, binding assays

    PMID:37849738

    Open questions at the time
    • Full-length EXOC4 structure not available
    • Structure of the EXOC4-PDZ complex not solved
    • How the spacer positions the ITTV motif for PDZ recognition not modeled at atomic resolution
  12. 2025 Medium

    Demonstrating that EXOC4 stabilizes STING1 by blocking FBXL19-mediated K27-linked ubiquitination and subsequent autophagic degradation, with conditional knockout mice showing increased HSV-1 susceptibility, established EXOC4 as a positive regulator of antiviral innate immunity against DNA viruses.

    Evidence Co-IP, K27-linkage-specific ubiquitination assays, STING1 mutagenesis, conditional KO mouse, viral infection, microscale thermophoresis

    PMID:40413753

    Open questions at the time
    • Whether this function is exocyst-complex-dependent or an independent moonlighting role not distinguished
    • Relevance to human antiviral immunity not validated
  13. 2026 Medium

    Discovering that p300-mediated acetylation at K433 triggers EXOC4 nuclear translocation where it facilitates PRMT5-dependent KU70 methylation to enhance NHEJ established a non-canonical nuclear function for this exocyst subunit in DNA repair.

    Evidence K433 mutagenesis, nuclear fractionation, co-IP, PRMT5 methylation assay, DNA-binding affinity assay, peptide inhibitor, preclinical models

    PMID:41826730

    Open questions at the time
    • How nuclear EXOC4 is distinguished from cytoplasmic exocyst pool not defined
    • Whether acetylation disrupts exocyst complex integrity not tested
    • Independent replication needed
  14. 2026 Medium

    Showing that EXOC4 stabilizes RIG-I by competing with STUB1 for CARD domain binding and suppressing STUB1 transcription via p53, with KO mice more susceptible to RNA virus infection, extended EXOC4's immune role to RNA virus sensing and provided a parallel to its STING1-stabilizing function.

    Evidence Co-IP binding competition, K48-linkage ubiquitination assays, K190 mutagenesis, Sec8-deficient mouse, viral infection assays

    PMID:41580425

    Open questions at the time
    • Dual mechanism (competitive binding + transcriptional suppression of STUB1) not independently confirmed
    • Whether STING1 and RIG-I stabilization are coordinated not explored

Open questions

Synthesis pass · forward-looking unresolved questions
  • It remains unresolved whether EXOC4's emerging non-canonical functions — innate immune sensor stabilization, nuclear DNA repair, and signaling regulation — operate independently of the exocyst complex or require its assembly, and how post-translational modifications (acetylation, phosphorylation) partition EXOC4 between these distinct functional pools.
  • No study has tested whether immune and nuclear functions require intact exocyst complex
  • Full-length EXOC4 structure in the context of the holocomplex not available
  • Relative physiological importance of vesicle tethering vs. moonlighting functions unknown

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060090 molecular adaptor activity 6 GO:0005198 structural molecule activity 2
Localization
GO:0005886 plasma membrane 4 GO:0005829 cytosol 2 GO:0031410 cytoplasmic vesicle 2 GO:0005634 nucleus 1
Pathway
R-HSA-5653656 Vesicle-mediated transport 5 R-HSA-1266738 Developmental Biology 2 R-HSA-1500931 Cell-Cell communication 2 R-HSA-162582 Signal Transduction 2 R-HSA-168256 Immune System 2 R-HSA-73894 DNA Repair 1
Partners
CREG1DLG1KU70PRMT5PSD-95RIG-ISAP102STING1
Complex memberships
exocyst complex

Evidence

Reading pass · 20 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1992 Sec8p (EXOC4 ortholog in S. cerevisiae) is a component of a 19.5S particle that also contains Sec15p, found both in the cytosol and peripherally associated with the plasma membrane but not with secretory vesicles; a portion of Sec4p (Rab GTPase) co-fractionates with the Sec8p/Sec15p particle, suggesting the complex functions as a downstream effector of Sec4p to direct secretory vesicle fusion with the plasma membrane. Fractionation, sucrose gradient sedimentation, gel filtration, cross-linking, immunoprecipitation The Journal of cell biology High 1512289
1995 Sec8 (EXOC4 ortholog) is a stable component of a large (~1–2 MDa) multisubunit exocyst complex (Sec6/8/15 containing at least 8 polypeptides) that localizes to small bud tips in S. cerevisiae; complex integrity is disrupted by mutations in sec3, sec5, and sec10, placing Sec8 within the core exocyst at sites of exocytosis. Immobilized metal affinity chromatography, gel filtration, sucrose velocity centrifugation, co-immunoprecipitation, immunofluorescence The Journal of cell biology High 7615633
1997 Mouse Sec8 (EXOC4) is required for paraxial mesoderm formation during embryogenesis; homozygous sec8 mutant embryos initiate but cannot progress beyond the primitive streak stage, demonstrating an essential role for Sec8 in early development. Gene trap mutagenesis, homozygous mutant embryo phenotypic analysis, cDNA cloning Developmental biology High 9441674
2003 Sec8 (EXOC4) binds to PDZ1-2 domains of PSD-95 via its C-terminal PDZ-binding motif (Thr-Thr-Val/TTV); this interaction is competed by cypin (cytosolic PSD-95 interactor) and is dependent on the TTV sequence; Sec8 and PSD-95 co-immunoprecipitate from brain tissue and share subcellular distribution. Co-immunoprecipitation, peptide competition assay, site-directed mutagenesis of TTV motif, immunoblotting of tissue fractions The Biochemical journal Medium 12675619
2005 In Drosophila (ortholog of mammalian EXOC4), Sec8 is required in vivo for regulation of synaptic microtubule density at the neuromuscular junction; sec8 null mutants show approximately doubled synaptic microtubule density and altered synapse morphology, with mild disruption of glutamate receptor trafficking but no effect on basal neurotransmission. Forward genetic screen, null mutant analysis, immunocytochemistry, electrophysiology, immunoblotting BMC biology High 16351720
2006 Sec8 (EXOC4) promotes oligodendrocyte morphological differentiation and myelin-like membrane formation; Sec8 co-localizes, co-immunoprecipitates, and co-fractionates with myelin protein OSP/Claudin11 and scaffolding protein CASK in oligodendrocytes, and siRNA knockdown of Sec8 inhibits membrane formation. siRNA knockdown, Sec8 overexpression, co-immunoprecipitation, co-fractionation, immunofluorescence colocalization Journal of cell science Medium 16478790
2009 In Schwann cells, Sec8 (EXOC4) interacts with Dlg1 (Discs large 1) scaffolding protein; the Dlg1–Sec8 interaction promotes membrane addition during myelination, while Dlg1–Mtmr2 interaction negatively regulates membrane formation, together constituting a homeostatic machinery that controls myelin membrane amount. Co-immunoprecipitation, Schwann cell/DRG neuron coculture, siRNA knockdown, Mtmr2-null mouse model with myelin outfolding phenotype The Journal of neuroscience Medium 19587293
2009 Insulin stimulates phosphorylation of Sec8 (EXOC4) at Ser-32 in 3T3-L1 adipocytes via a PI3K-dependent pathway consistent with Akt as the kinase; however, overexpression of non-phosphorylatable (S32A) or phosphomimetic (S32E) Sec8 mutants had no effect on GLUT4 or transferrin receptor trafficking to the plasma membrane. Phosphoproteomics (MS), wortmannin inhibitor assay, site-directed mutagenesis (S32A/S32E), surface GLUT4 assay Bioscience reports Medium 19006485
2012 Sec8 (EXOC4) knockdown reduces the secretion of matrix metalloproteinases MMP-2, proMMP-2, and proMMP-9 and reduces cellular invasiveness in oral squamous-cell carcinoma cells, consistent with a role for Sec8 in vesicle-mediated MMP secretion. siRNA knockdown, gelatin zymography, invasion assay, proliferation assay Journal of cancer research and clinical oncology Low 23207790
2014 Sec8 (EXOC4) knockdown promotes G1/S cell-cycle arrest by increasing p21(Cip1) expression; mechanistically, Sec8 regulates FOXO family transcription factors through ubiquitin-proteasome degradation by controlling Mdm2 protein expression (but not Skp2), thereby controlling p21 levels and Rb phosphorylation. siRNA knockdown, cell-cycle analysis, immunoblotting, proteasome inhibition The FEBS journal Low 24299491
2014 Sec8 (EXOC4) binds to JIP4 (JNK-interacting protein 4) scaffold protein; Sec8 knockdown enhances JIP4 binding to MKK4, decreasing phosphorylation of MKK4, JNK, and p38 under apoptotic conditions, indicating Sec8 regulates the JIP4-MKK4-JNK/p38 MAPK signaling cascade. siRNA knockdown, co-immunoprecipitation, immunoblotting of phosphorylated MAPK pathway components The FEBS journal Low 25244576
2015 Sec8 (EXOC4) knockdown suppresses cell migration by reducing phosphorylation of cytokeratin8 at Ser73; this is mediated through the ERK and p38 MAPK signaling pathways via downregulation of p21-activated kinases by Pirh2 and Siah1. siRNA knockdown, migration assay, immunoblotting of phosphorylated cytokeratin8 and MAPK pathway components Cellular signalling Low 25725287
2016 Sec8 (EXOC4) regulates N-cadherin expression by controlling Smad3 and Smad4 expression at the basal transcriptional level through CBP (CREB-binding protein), thereby modulating TGF-β-induced epithelial-mesenchymal transition (EMT), cell migration, and adhesion. siRNA knockdown, immunoblotting, RT-PCR for transcriptional regulation, cell migration and adhesion assays Cellular signalling Low 27769780
2016 CREG1 directly interacts with Sec8 (EXOC4), and this interaction is required for cardiomyocyte differentiation and cell-cell cohesion; CREG1, Sec8, and N-cadherin co-localize at intercalated discs and are enriched at cell-cell junctions; CREG1 overexpression enhances adherens and gap junction assembly, while CREG1 knockout inhibits the Sec8–N-cadherin interaction and induces their degradation. Co-immunoprecipitation, site-directed mutagenesis, CREG1 knockout ES cells rescue assay, immunofluorescence colocalization, gain/loss-of-function Stem cells (Dayton, Ohio) Medium 27334848
2021 LRRK2 interacts with Sec8 (EXOC4) and regulates the assembly of exocyst complex subunits through its kinase activity; overexpression of Sec8 significantly rescues the pathological effects of the LRRK2 G2019S Parkinson's disease mutation, suggesting LRRK2 modulates vesicle trafficking via the exocyst. Co-immunoprecipitation, LRRK2 kinase inhibitor/domain truncation analysis, Sec8 overexpression rescue of LRRK2 G2019S mutant phenotype Cells Low 33498474
2022 EXOC4 promotes diffuse-type gastric cancer metastasis by regulating phosphorylation of focal adhesion kinase (FAK) at Y397; mechanistically, EXOC4 stimulates secretion of integrin α5/β1 and EGF, enhancing the interaction of FAK with integrin or EGFR and thereby activating FAK signaling. LC/MS-MS proteomics, cell migration/invasion assays, FAK phosphorylation immunoblotting, FAK inhibitor (VS-4718) treatment, patient-derived xenograft models Molecular cancer research : MCR Medium 35471457
2023 Crystal structure (2.5 Å resolution) of the C-terminal half of Sec8 (EXOC4) reveals an unusually long C-terminal helix with a 14-residue spacer bridging the ITTV PDZ-binding motif to the compact Sec8 core; Sec8 preferentially binds PDZ2 over PDZ1 and PDZ3 of SAP102, and deletion of the spacer completely abolishes SAP102 binding. X-ray crystallography, binding assays, deletion mutagenesis, structural modeling Frontiers in cell and developmental biology High 37849738
2025 EXOC4/SEC8 stabilizes STING1 by suppressing K27-linked ubiquitination of STING1 at K338, K347, and K370 catalyzed by E3 ligase FBXL19, thereby preventing SQSTM1-mediated autophagic degradation of STING1 and promoting type I interferon signaling in response to DNA viruses; conditional Exoc4/Sec8 knockout mice show increased susceptibility to HSV-1 infection. Co-immunoprecipitation, ubiquitination assays (K27-linkage specific), site-directed mutagenesis of STING1 ubiquitination sites, conditional knockout mouse, viral infection assays, microscale thermophoresis Autophagy Medium 40413753
2026 EXOC4 undergoes p300-mediated acetylation at lysine 433, which triggers its nuclear translocation; in the nucleus, EXOC4 facilitates interaction between PRMT5 and KU70, inducing PRMT5-catalyzed methylation of KU70 at arginine 318, which increases KU complex DNA-binding affinity and accelerates double-strand break repair by non-homologous end joining (NHEJ), thereby promoting chemoradiotherapy resistance. Acetylation mutagenesis (K433), nuclear fractionation, co-immunoprecipitation, PRMT5 methylation assay, DNA-binding affinity assay, peptide inhibitor targeting K433, preclinical models Cell death and differentiation Medium 41826730
2026 Sec8 (EXOC4) stabilizes RIG-I by competing with E3 ligase STUB1 for binding to RIG-I's CARD domain and by suppressing STUB1 mRNA expression through reducing p53 levels, thereby preventing K48-linked ubiquitination of RIG-I at Lys190 and its proteasomal degradation, and enhancing type I interferon signaling against RNA viruses; Sec8-deficient mice show increased susceptibility to RNA virus infection. Co-immunoprecipitation (binding competition), ubiquitination assays (K48-linkage), site-directed mutagenesis (Lys190), Sec8-deficient mouse, viral infection assays, immunoblotting Cell death & disease Medium 41580425

Source papers

Stage 0 corpus · 28 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1995 Sec6, Sec8, and Sec15 are components of a multisubunit complex which localizes to small bud tips in Saccharomyces cerevisiae. The Journal of cell biology 257 7615633
2005 SEC8, a subunit of the putative Arabidopsis exocyst complex, facilitates pollen germination and competitive pollen tube growth. Plant physiology 140 16040664
2010 Arabidopsis exocyst subunits SEC8 and EXO70A1 and exocyst interactor ROH1 are involved in the localized deposition of seed coat pectin. The New phytologist 98 20618910
1992 Sec8p and Sec15p are components of a plasma membrane-associated 19.5S particle that may function downstream of Sec4p to control exocytosis. The Journal of cell biology 96 1512289
2009 Dlg1, Sec8, and Mtmr2 regulate membrane homeostasis in Schwann cell myelination. The Journal of neuroscience : the official journal of the Society for Neuroscience 89 19587293
1997 The secretory protein Sec8 is required for paraxial mesoderm formation in the mouse. Developmental biology 67 9441674
2003 Exocyst complex subunit sec8 binds to postsynaptic density protein-95 (PSD-95): a novel interaction regulated by cypin (cytosolic PSD-95 interactor). The Biochemical journal 34 12675619
2005 Increased synaptic microtubules and altered synapse development in Drosophila sec8 mutants. BMC biology 31 16351720
2016 Sec8 modulates TGF-β induced EMT by controlling N-cadherin via regulation of Smad3/4. Cellular signalling 29 27769780
2006 A role for Sec8 in oligodendrocyte morphological differentiation. Journal of cell science 28 16478790
2016 CREG1 Interacts with Sec8 to Promote Cardiomyogenic Differentiation and Cell-Cell Adhesion. Stem cells (Dayton, Ohio) 25 27334848
2014 Knockdown of Sec8 promotes cell-cycle arrest at G1/S phase by inducing p21 via control of FOXO proteins. The FEBS journal 24 24299491
2012 Exocyst complex component Sec8: a presumed component in the progression of human oral squamous-cell carcinoma by secretion of matrix metalloproteinases. Journal of cancer research and clinical oncology 23 23207790
2015 Sec8 regulates cytokeratin8 phosphorylation and cell migration by controlling the ERK and p38 MAPK signalling pathways. Cellular signalling 20 25725287
2014 Knockdown of Sec8 enhances the binding affinity of c-Jun N-terminal kinase (JNK)-interacting protein 4 for mitogen-activated protein kinase kinase 4 (MKK4) and suppresses the phosphorylation of MKK4, p38, and JNK, thereby inhibiting apoptosis. The FEBS journal 20 25244576
2008 Polymorphisms near EXOC4 and LRGUK on chromosome 7q32 are associated with Type 2 Diabetes and fasting glucose; the NHLBI Family Heart Study. BMC medical genetics 16 18498660
2009 Insulin stimulates the phosphorylation of the exocyst protein Sec8 in adipocytes. Bioscience reports 15 19006485
2005 Association between single-nucleotide polymorphisms in the SEC8L1 gene, which encodes a subunit of the exocyst complex, and rheumatoid arthritis in a Japanese population. Arthritis and rheumatism 15 15880602
2022 Altered methylation pattern in EXOC4 is associated with stroke outcome: an epigenome-wide association study. Clinical epigenetics 13 36180927
2022 EXOC4 Promotes Diffuse-Type Gastric Cancer Metastasis via Activating FAK Signal. Molecular cancer research : MCR 12 35471457
2021 The Association of an SNP in the EXOC4 Gene and Reproductive Traits Suggests Its Use as a Breeding Marker in Pigs. Animals : an open access journal from MDPI 9 33671441
2010 Different steps of sexual development are differentially regulated by the Sec8p and Exo70p exocyst subunits. FEMS microbiology letters 7 20180855
2025 Unveiling EXOC4/SEC8: a key player in enhancing antiviral immunity by inhibiting the FBXL19-STING1-SQSTM1 signaling axis. Autophagy 3 40413753
2023 Case Report: Co-existence of a novel EXOC4-TRHDE gene fusion with PML-RARA in acute promyelocytic leukemia. Frontiers in oncology 1 37152017
2023 Sec8 specifically interacts with the PDZ2 domain of synapse associated protein 102 (SAP102). Frontiers in cell and developmental biology 1 37849738
2021 LRRK2 Modulates the Exocyst Complex Assembly by Interacting with Sec8. Cells 1 33498474
2026 Sec8: a novel positive regulator of RIG-I in anti-RNA viral defense. Cell death & disease 0 41580425
2026 Acetylation-dependent nuclear translocation of EXOC4 regulates KU70 methylation to facilitate non-homologous end joining. Cell death and differentiation 0 41826730