Affinage

CDH1

Cadherin-1 · UniProt P12830

Length
882 aa
Mass
97.5 kDa
Annotated
2026-06-09
100 papers in source corpus 39 papers cited in narrative 39 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 9/9 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

The CDH1 timeline describes two distinct, internally coherent proteins that share the symbol: the cell-adhesion molecule E-cadherin/uvomorulin and the APC/C co-activator Cdh1/Fzr1. As an adhesion molecule, uvomorulin/E-cadherin is a Ca2+-dependent transmembrane glycoprotein whose extracellular region is built from internally repeated domains carrying putative Ca2+-binding sites and whose membrane-proximal cysteine cluster contributes a conformational requirement for adhesion (PMID:3501370, PMID:1710917); it mediates the early adhesion event prerequisite for assembly of the entire epithelial junctional complex and concentrates at the zonula adherens (PMID:3049625, PMID:3880756). Its cytoplasmic tail recruits the catenins through a discrete ~72-residue domain, with beta-catenin binding directly and alpha-catenin (a vinculin homologue) linking the complex to actin filaments; this catenin association is required for adhesive function (PMID:2788574, PMID:2349235, PMID:1924379). The protein is synthesized as a 135 kDa precursor processed to the mature 120 kDa form in the late Golgi, and correct pro-peptide cleavage is essential to activate adhesion, while the complex is delivered directly to the basolateral surface of polarized epithelia (PMID:2211831, PMID:1918074, PMID:2335561). Functionally, E-cadherin-mediated contact inhibits invasive migration, and its gene is epigenetically silenced during EMT via HMGA2-directed DNMT3A recruitment and promoter hypermethylation (PMID:1649199, PMID:25492890). The unrelated APC/C co-activator Cdh1/Fzr1 confers substrate specificity on the anaphase-promoting complex to drive ubiquitin-mediated proteolysis controlling cell-cycle exit and G1 maintenance, targeting CDC6, cyclin B1, Skp2, and IDH3β, and recognizing substrates through destruction-box and KEN-box motifs (PMID:10995389, PMID:16148219, PMID:31806563, PMID:31053633, PMID:25349192). Its inactivation—a bistable switch initiated by cyclin E/Cdk2 and locked in by Emi1—marks the irreversible commitment to cell-cycle entry (PMID:27368103). APC/C(Cdh1) enforces the G2 DNA-damage checkpoint through Cdc14B-dependent degradation of Plk1 and controls DNA-end resection and homologous recombination via CtIP turnover (PMID:18662541, PMID:25349192). Beyond the cycle it degrades LATS kinases to gate Hippo/YAP signaling, sustains neuronal survival and dendritic integrity by clearing cyclin B1 and Rock2, and governs neurogenesis, cerebellar progenitor expansion, craniofacial development, and muscle satellite-cell maintenance through substrates including CK1δ, FoxM1, and non-proteolytic ubiquitination of Goosecoid (PMID:31000600, PMID:16148219, PMID:28396402, PMID:24301314, PMID:25843713, PMID:32152291, PMID:27126000). Cdh1 is itself controlled by phosphorylation that blocks its nuclear import and APC core binding, by APC/C-mediated auto-degradation, and by inhibitory phosphorylation from JNK, c-Src, and Cdk5, the last linking its inactivation to Rock2 stabilization in amyloid-β neurotoxicity (PMID:12560341, PMID:15029244, PMID:20581839, PMID:31420536, PMID:35496276).

Mechanistic history

Synthesis pass · year-by-year structured walk · 25 steps
  1. 1987 High

    Establishing the domain architecture of uvomorulin was needed to understand how a single transmembrane protein could mediate Ca2+-dependent adhesion; protein sequencing revealed the modular extracellular repeats with Ca2+-binding loops.

    Evidence Protein sequencing and secondary-structure prediction of purified uvomorulin with comparison to L-CAM

    PMID:3501370

    Open questions at the time
    • Ca2+-binding sites inferred from sequence, not structurally resolved
    • homophilic binding interface not defined
  2. 1985 Medium

    Pinpointing which region mediates adhesion was needed; function-blocking antibodies and protease mapping localized adhesive activity to a 26 kDa extracellular fragment and to the zonula adherens.

    Evidence Monoclonal antibody (DECMA-1) blocking of compaction/MDCK adhesion plus proteolytic epitope mapping; immuno-EM localization

    PMID:2419126 PMID:3880756

    Open questions at the time
    • fragment identity at residue level not defined
    • single-lab localization
  3. 1988 High

    Whether adhesion drives broader junction assembly was unresolved; Ca2+-switch blocking showed uvomorulin engagement is prerequisite for assembling all junctional elements.

    Evidence Ca2+ switch assay with blocking antibodies, junction-marker staining, and transepithelial resistance in MDCK cells

    PMID:3049625

    Open questions at the time
    • molecular link between adhesion and tight-junction nucleation not defined
  4. 1989 High

    How the cytoplasmic tail connects to the cytoskeleton was unknown; co-IP with deletion mutants identified the three catenins as conserved tail-associated partners.

    Evidence Co-immunoprecipitation with cytoplasmic vs extracellular deletion constructs across multiple cell lines

    PMID:2788574

    Open questions at the time
    • direct vs indirect binding of each catenin not yet resolved here
  5. 1990 High

    Mapping the catenin-binding determinant and testing its functional necessity defined a 72-residue cytoplasmic domain required for adhesion, with beta-catenin binding directly and alpha-catenin linking to actin.

    Evidence Chimeric/deletion constructs in L cells, immunoprecipitation, actin-bundle fractionation, and cell aggregation assays

    PMID:2349235

    Open questions at the time
    • atomic details of catenin-tail contacts not defined
  6. 1990 High

    Whether the mature protein required correct biosynthetic processing and where it is delivered was unclear; pro-peptide cleavage was shown essential for adhesion and the protein targeted directly to the basolateral surface.

    Evidence Cleavage-site mutagenesis with protease rescue and adhesion assays; domain-selective surface biotinylation in MDCK cells

    PMID:2211831 PMID:2335561

    Open questions at the time
    • basolateral targeting signal not mapped
    • physiological protease identity not defined
  7. 1991 High

    Defining alpha-catenin's identity and complex assembly clarified the cytoskeletal link and showed catenins associate with multiple cadherins; biosynthesis tracking established complex stoichiometry and assembly order.

    Evidence Cloning of alpha-catenin (vinculin homology), co-IP across cadherins, localization in transfected L cells; pulse-chase stoichiometry; biosynthetic maturation analysis

    PMID:1734027 PMID:1918074 PMID:1924379

    Open questions at the time
    • regulation of complex assembly timing not fully resolved
    • glycosylation dispensable but role unclear
  8. 1991 High

    Whether E-cadherin function extends beyond static adhesion was tested; ectopic expression showed contact-dependent inhibition of invasion, and it was confirmed the principal Ca2+-dependent adhesion molecule of islet cells.

    Evidence Stable transfection of L cells, 3D collagen invasion and wound assays with antibody reversal; Fab-blocking aggregation in islet cells

    PMID:1649199 PMID:1936561

    Open questions at the time
    • signaling pathway mediating contact inhibition not defined
  9. 1996 Low

    Whether phosphorylation regulates adhesion during compaction was probed; phosphorylation tracked with compaction but did not directly control adhesive function.

    Evidence Correlative phosphorylation analysis in mouse embryos under compaction-perturbing conditions

    PMID:8722695

    Open questions at the time
    • correlative only, no causal manipulation
    • phosphosite and kinase not identified
  10. 2000 High

    The basis of G1 substrate proteolysis by the APC/C co-activator was unknown; CDH1 was shown to ubiquitinate CDC6 via destruction-box/KEN-box recognition.

    Evidence In vitro ubiquitination, degradation-signal mutagenesis, and in vivo CDH1 depletion

    PMID:10995389

    Open questions at the time
    • full G1 substrate repertoire not yet defined
  11. 2003 Medium

    How Cdh1 activity is spatially and temporally restricted was addressed; an NLS drives nuclear import that is blocked by phosphorylation of NLS serines/threonines.

    Evidence GFP-Cdh1 live imaging, phosphomimetic mutants, NLS-fusion targeting, cyclin A correlation

    PMID:12560341

    Open questions at the time
    • responsible kinase(s) not identified
    • single-lab localization
  12. 2004 High

    How Cdh1 levels themselves are controlled was unresolved; Cdh1 was shown to drive its own APC/C-mediated auto-degradation via RXXL destruction boxes.

    Evidence Destruction-box mutagenesis, Xenopus extract APC/C activation, and cell-cycle level analysis

    PMID:15029244

    Open questions at the time
    • physiological trigger of auto-degradation timing not defined
  13. 2005 High

    Whether APC/C-Cdh1 has a postmitotic role was unknown; in neurons it keeps cyclin B1 low to prevent aberrant cell-cycle re-entry and apoptosis.

    Evidence shRNA knockdown in postmitotic neurons with cyclin B1, BrdU, and apoptosis readouts

    PMID:16148219

    Open questions at the time
    • additional neuronal substrates not identified here
  14. 2008 High

    How APC/C-Cdh1 enforces the G2 DNA-damage checkpoint was defined; Cdc14B activates APC/C(Cdh1) to degrade Plk1, stabilizing Claspin and Wee1.

    Evidence Cdc14B translocation imaging, Plk1/Claspin/Wee1 stability assays, Cdh1 siRNA, checkpoint analysis

    PMID:18662541

    Open questions at the time
    • upstream activation of Cdc14B relay not fully resolved
  15. 2009 Medium

    Substrate discovery extended the Cdh1 network; Claspin and TACC3 were identified as Cdh1 substrates, and Cdh1 was linked to Rb/E2F regulation and senescence control.

    Evidence AP-MS and yeast two-hybrid substrate identification with co-IP, ubiquitination, siRNA, and senescence/S-phase assays

    PMID:19477924 PMID:19823035

    Open questions at the time
    • context-dependence of senescence vs S-phase outcomes not reconciled
  16. 2010 High

    Reciprocal regulation of Cdh1 by mitotic kinases was uncovered; JNK is both an APC/C(Cdh1) substrate and a kinase that phosphorylates Cdh1 to restrain its activity in G2/M.

    Evidence Co-IP, in vitro kinase assay, non-degradable JNK expression with mitotic arrest phenotype

    PMID:20581839

    Open questions at the time
    • phosphosites on Cdh1 not fully mapped
  17. 2013 High

    The in vivo developmental requirement for Cdh1 was tested; embryonic Cdh1 knockout delays neural progenitor cell-cycle exit, causing replicative stress and p53-driven apoptosis and reduced cortex size.

    Evidence Embryo-restricted Cdh1 knockout mouse with differentiation, cortex-size, and p53-pathway analysis

    PMID:24301314

    Open questions at the time
    • specific substrate driving the neurogenesis defect not isolated
  18. 2014 High

    Cdh1's role in DNA repair regulation was defined; APC/C(Cdh1) controls CtIP stability through a KEN box, tuning end-resection and homologous recombination.

    Evidence Proteomics, co-IP, KEN-box mutagenesis, damage-foci and HR-efficiency assays

    PMID:25349192

    Open questions at the time
    • balance with other resection regulators not quantified
  19. 2015 Medium

    Cdh1 control of cerebellar progenitors was probed; CK1δ was identified as a substrate whose downregulation governs granule progenitor cell-cycle exit.

    Evidence Conditional Cdh1 deletion in cerebellar GCPs with CK1δ level and proliferation assays

    PMID:25843713

    Open questions at the time
    • direct ubiquitination kinetics of CK1δ not fully characterized
  20. 2016 High

    The decision-making logic of cell-cycle entry was clarified; APC/C(Cdh1) inactivation is a bistable, irreversible commitment switch initiated by cyclin E/Cdk2 and locked by Emi1.

    Evidence Single-cell live imaging reporter with Cdk2 and Emi1 perturbations and stress challenges

    PMID:27368103

    Open questions at the time
    • molecular feedback architecture of bistability not fully reconstituted
  21. 2016 Medium

    A non-degradative Cdh1 output in development was found; Cdh1 directs APC-dependent monoubiquitination and transcriptional activation of Goosecoid to control craniofacial bone formation.

    Evidence Neural-crest-specific Cdh1 knockout, Gsc ubiquitination and target-gene analysis, craniofacial phenotyping

    PMID:27126000

    Open questions at the time
    • how monoubiquitination activates Gsc transcription mechanistically unclear
  22. 2017 High

    Cdh1 was linked to growth-control signaling and neuronal maintenance; it degrades LATS kinases to time YAP/TAZ activity and degrades Rock2 to preserve dendrites and memory.

    Evidence Co-IP, stability and reporter assays, Drosophila epistasis; conditional Cdh1 KO with Rock2 readouts and fasudil rescue

    PMID:28396402 PMID:31000600

    Open questions at the time
    • crosstalk between Hippo and cell-cycle Cdh1 functions not integrated
  23. 2019 High

    Additional metabolic and oncogenic substrates and an APC-independent function emerged; Cdh1 degrades Skp2 and IDH3β and suppresses c-Src, while c-Src reciprocally phosphorylates Cdh1 to inhibit APC core binding.

    Evidence Co-IP, ubiquitination, CRISPR rescue, half-life, in vitro kinase assay, and xenograft/mouse tumor models

    PMID:31053633 PMID:31420536 PMID:31806563

    Open questions at the time
    • mechanism of APC-independent c-Src suppression not defined
  24. 2020 Medium

    Tissue- and stress-specific Cdh1 functions were extended; Cdh1-FoxM1 controls muscle satellite-cell maintenance, an APC-Cdh1-cyclin B1 route drives a slow oocyte DDR, and Cdh1-APC influences neuronal protein synthesis via stress-granule/FMRP interactions.

    Evidence Conditional KO with FoxM1 rescue; Setx-null oocyte DDR analysis; interactome/stress-granule assays with FMRP knockdown

    PMID:32152291 PMID:32328643 PMID:32434143

    Open questions at the time
    • FMRP as direct Cdh1-APC substrate not rigorously demonstrated
    • generality of slow oocyte DDR pathway unclear
  25. 2022 Medium

    Disease-relevant and mitosis-specific substrate recognition was probed; Cdk5 phosphorylation disassembles Cdh1 from APC/C in amyloid-β toxicity stabilizing Rock2, and dephosphorylated STAT3 is a preferred mitotic substrate.

    Evidence Phosphomutant rescue, co-IP, Rock2 stability and apoptosis assays; cell-cycle-resolved co-IP and ubiquitination with phosphatase inhibition

    PMID:35496276 PMID:36400381

    Open questions at the time
    • STAT3 finding based on single-lab co-IP/ubiquitination with limited functional follow-up
    • in vivo relevance of STAT3 turnover not established

Open questions

Synthesis pass · forward-looking unresolved questions
  • It remains unresolved how the two distinct proteins sharing the CDH1 symbol—E-cadherin adhesion molecule and APC/C co-activator Fzr1/Cdh1—are functionally delineated, and a structural basis for E-cadherin homophilic binding and for Cdh1 substrate-motif selectivity is not established in this corpus.
  • no structural model of E-cadherin trans-dimer
  • no unified rule for Cdh1 KEN/D-box substrate selection
  • symbol collision risk between the two proteins

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0098631 cell adhesion mediator activity 4 GO:0140096 catalytic activity, acting on a protein 4 GO:0008092 cytoskeletal protein binding 3 GO:0016874 ligase activity 3 GO:0098772 molecular function regulator activity 3
Localization
GO:0005886 plasma membrane 3 GO:0005829 cytosol 2 GO:0005634 nucleus 1 GO:0005815 microtubule organizing center 1
Pathway
R-HSA-1640170 Cell Cycle 4 R-HSA-392499 Metabolism of proteins 4 R-HSA-1266738 Developmental Biology 3 R-HSA-1500931 Cell-Cell communication 2 R-HSA-73894 DNA Repair 2 R-HSA-162582 Signal Transduction 1
Partners
CDC6CTIPCTNNA1CTNNB1LATSPLK1ROCK2SKP2
Complex memberships
APC/Cuvomorulin-catenin complex / adherens junction

Evidence

Reading pass · 39 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1989 The cytoplasmic domain of uvomorulin (CDH1/E-cadherin) associates with three independent proteins of 102, 88, and 80 kDa (named catenin alpha, beta, and gamma, respectively), as demonstrated by immunoprecipitation using cytoplasmic vs. extracellular deletion constructs; these catenins are conserved across species and form a new protein group linking uvomorulin to the cytoskeleton. Co-immunoprecipitation with deletion mutants expressed in NIH 3T3, L cells, HeLa, and avian fibroblasts; peptide pattern analysis The EMBO journal High 2788574
1988 Uvomorulin mediates an early adhesion event that is prerequisite for assembly of all elements of the epithelial junctional complex (zonula adherens, zonula occludens, desmosomes); inhibition with blocking antibodies/Fab fragments prevents junction formation in a Ca2+ switch assay, but established tight junctions are resistant to antibody disruption. Ca2+ switch assay with blocking antibodies and Fab fragments; fluorescence staining for ZO-1, actin (ZA), desmoplakin; transepithelial resistance measurement in MDCK cells The Journal of cell biology High 3049625
1990 Catenin complex formation with uvomorulin is mediated by a specific 72-amino acid domain (encoded largely by a single exon) in the cytoplasmic region; catenin beta binds more directly to this domain while catenin alpha mediates association with actin filaments; catenin binding is required for adhesive function of uvomorulin in cell aggregation assays. Expression of chimeric H-2Kd/uvomorulin constructs and deletion mutants in L cells; immunoprecipitation; cell aggregation assays; biochemical fractionation with actin bundles Proceedings of the National Academy of Sciences of the United States of America High 2349235
1987 The extracellular domain of uvomorulin contains three internally repeated domains of 112 residues (generated by gene duplication), each with two putative Ca2+-binding sites in external loops; the protein also has a single transmembrane region and a cytoplasmic domain, showing 65% identity to chicken L-CAM. Protein sequencing of purified uvomorulin; amino acid sequence analysis and secondary structure prediction; sequence comparison The EMBO journal High 3501370
1985 A 26 kDa extracellular fragment of uvomorulin, generated by protease digestion and recognized by blocking monoclonal antibody DECMA-1, is implicated in the adhesive function; the same fragment is recognized by other function-blocking antibodies that disrupt MDCK monolayers. Monoclonal antibody blocking of embryo compaction and MDCK cell adhesion; protease digestion mapping of antigenic fragment; immunoreactivity comparison across blocking antibodies The EMBO journal Medium 2419126
1985 Uvomorulin localizes to the intermediate junctions (zonula adherens) of adult intestinal epithelial cells, as demonstrated by electron microscopic immunolocalization. Electron microscopy with immunolabeling of adult intestinal epithelial cells The Journal of cell biology Medium 3880756
1991 Alpha-catenin is a vinculin homologue and complexes with multiple cadherins (uvomorulin/E-cadherin, N-cadherin, P-cadherin, A-CAM, U-cadherin); in cadherin-negative L cells, alpha-catenin is diffusely cytoplasmic but concentrates at membrane contacts upon uvomorulin expression, suggesting it mediates cytoskeletal anchorage downstream of cadherin engagement. Immunoprecipitation with anti-alpha-catenin antibodies; molecular cloning and sequence analysis; immunofluorescence in cadherin-negative and uvomorulin-transfected L cells Proceedings of the National Academy of Sciences of the United States of America High 1924379
1992 The uvomorulin-catenin complex is composed of one molecule of uvomorulin, one or two molecules of beta-catenin, and one molecule of alpha-catenin; beta-catenin associates with the uvomorulin precursor (135 kDa) early in biosynthesis whereas alpha-catenin joins the complex later, around the time of endoproteolytic processing. Biochemical analysis of immunoprecipitated complexes; pulse-chase experiments; stoichiometry analysis The Journal of cell biology High 1734027
1990 Correct proteolytic processing of the uvomorulin precursor segment is required for its cell adhesive function; unprocessed uvomorulin that reaches the cell surface forms catenin complexes and is Ca2+-protected but is non-functional in cell adhesion assays; cleavage at the correct site activates adhesion while cleavage at incorrect sites does not, indicating the amino-terminal region of mature uvomorulin is important for adhesion. Site-directed mutagenesis of protease recognition sites; expression of mutant polypeptides in L cells; cell adhesion assays; treatment with specific proteases (factor Xa, trypsin) The Journal of cell biology High 2211831
1991 E-cadherin (uvomorulin)-mediated cell-cell contacts inhibit invasive migration of L cells into collagen gels in a cell density-dependent manner, establishing E-cadherin as a contact inhibitor of invasion; single cells expressing E-cadherin show normal invasiveness, indicating the effect requires cell-cell contact. Stable transfection of L cells with E-cadherin cDNA; 3D collagen gel invasion assay; blocking antibody reversal experiment; time-lapse videoscopy; wound closure assay The Journal of cell biology High 1649199
1991 Uvomorulin is synthesized as a 135 kDa precursor glycosylated in the endoplasmic reticulum, processed to the mature 120 kDa form in the late Golgi prior to cell surface delivery; glycosylation is not required for processing or surface transport; surface uvomorulin has a t½ of ~5 h and becomes Triton X-100 insoluble and concentrates at cell contacts upon Ca2+-dependent adhesion. Pulse-chase biosynthetic labeling; domain-selective biotinylation; Triton X-100 fractionation in MDCK cells; tunicamycin inhibition of glycosylation The Journal of biological chemistry High 1918074
1990 Uvomorulin is delivered directly to the basolateral surface of MDCK cells with only 2% mistargeting to the apical domain, establishing its direct basolateral targeting in polarized epithelial cells. Pulse-chase combined with domain-selective cell-surface biotinylation and streptavidin-agarose precipitation in MDCK cells The Journal of cell biology Medium 2335561
1990 The membrane-proximal region of uvomorulin, containing a cluster of cysteine residues, is involved in the adhesive mechanism; reduction of disulfide bonds by DTT blocks close cell-cell contacts and cell flattening (but not aggregation) and increases trypsin susceptibility of this region, indicating a conformational contribution to adhesion. DTT treatment of cells; cell adhesion assays; trypsin sensitivity assay of membrane-proximal domain; epitope mapping of DECMA-1 Mechanisms of development Medium 1710917
1991 Uvomorulin is the dominant functional cadherin on pancreatic islet cells mediating Ca2+-dependent aggregation; anti-uvomorulin Fab fragments block B-cell aggregation to the same extent as EDTA (Ca2+ chelation), confirming its role as the principal Ca2+-dependent adhesion molecule in islets. Anti-uvomorulin Fab fragment blocking of islet cell aggregation; flow cytometry; sorting of B- and non-B-cells; mild trypsin/Ca2+ digestion to remove Ca2+-independent CAMs Developmental biology Medium 1936561
1996 Uvomorulin is phosphorylated at the 8-cell stage during compaction; prevention of compaction by prolonged low Ca2+ exposure reduces the level of uvomorulin phosphorylation and perturbs its localization to cell-cell contacts, though phosphorylation does not appear to directly regulate adhesive function. Phosphorylation analysis in mouse embryos under conditions preventing, reversing, or inducing compaction; immunolocalization Molecular reproduction and development Low 8722695
2000 CDC6 is targeted for ubiquitin-mediated proteolysis by APC/C in complex with CDH1 (APC-CDH1) during G1; CDH1 ubiquitinates CDC6 in vitro; destruction box and KEN-box mutations in CDC6 stabilize it in G1 and quiescent cells; both APC and CDH1 are required and limiting for CDC6 proteolysis in vivo. In vitro ubiquitination assay with APC-CDH1; point mutagenesis of destruction box and KEN-box; in vivo proteolysis assay with CDH1 depletion; cell cycle analysis Genes & development High 10995389
2003 CDH1 (APC/C coactivator) localizes dynamically to the nucleus during interphase and to the centrosome during metaphase and anaphase; nuclear accumulation correlates with reduction of cyclin A; a nuclear localization signal (NLS) in CDH1 drives nuclear import; phosphorylation of serine/threonine residues in the NLS inhibits nuclear import, keeping hyperphosphorylated CDH1 in the cytoplasm. GFP-CDH1 live-cell imaging; CDH1-4D phosphomimetic mutant localization; NLS-GFP fusion targeting assay; cyclin A immunostaining correlation; cell cycle staging The Journal of biological chemistry Medium 12560341
2004 Mammalian CDH1 (Fzr) undergoes APC/C-mediated auto-degradation during G1 and G0 via two RXXL-type destruction boxes; CDH1 activates APC/C to degrade itself; destruction-box mutations stabilize CDH1 in G1/G0. Mutation of destruction boxes in CDH1; Xenopus interphase extract APC/C activation assay; cell cycle analysis of CDH1 levels; APC/C co-immunoprecipitation The EMBO journal High 15029244
2005 Cdh1-APC (APC/C-Cdh1) is active in postmitotic neurons and required for their survival; Cdh1 depletion by shRNA causes cyclin B1 accumulation, aberrant S-phase entry, and apoptotic death in terminally differentiated neurons, demonstrating that Cdh1 prevents aberrant cell cycle re-entry by keeping cyclin B1 low. shRNA knockdown of Cdh1 in postmitotic neurons; cyclin B1 immunoblot; BrdU incorporation for S-phase entry; apoptosis assay The Journal of neuroscience High 16148219
2008 In the G2 DNA damage response, Cdc14B phosphatase translocates from the nucleolus to the nucleoplasm and activates APC/C(Cdh1), which then degrades Plk1; this stabilizes Claspin and Wee1 to enforce G2 checkpoint arrest; Claspin is also an APC/C(Cdh1) substrate in G1 and is protected from degradation by deubiquitylase Usp28 in response to G2 damage. Cdc14B translocation imaging; Plk1 degradation assay after DNA damage; Claspin and Wee1 stability assays; Cdh1 siRNA depletion; G2 checkpoint analysis Cell High 18662541
2009 Claspin is a novel Cdh1 substrate; Cdh1 inactivation leads to Claspin accumulation and activation of the Claspin/Chk1 pathway; Cdh1 also competes with E2F1 to bind hypophosphorylated Rb, reciprocally regulating the Rb pathway; acute Cdh1 depletion in primary fibroblasts (with intact p53/Rb) induces premature senescence, while depletion in HeLa cells causes premature S-phase entry. Affinity purification-mass spectrometry; co-immunoprecipitation of Claspin-Cdh1; siRNA knockdown; Chk1 activation assay; senescence assay; S-phase entry analysis Molecular biology of the cell Medium 19477924
2009 Cdh1 controls TACC3 protein stability through APC/C; Cdh1 physically interacts with TACC3; Cdh1 depletion prolongs TACC3 levels during mitotic exit; overexpression or knockdown of Cdh1 increases or decreases ubiquitinated TACC3, respectively; multiple domains of TACC3 are involved in Cdh1-regulated degradation. Yeast two-hybrid screen; co-immunoprecipitation; siRNA knockdown; ubiquitination assay; domain mapping Cell cycle Medium 19823035
2010 Nuclear-localized JNK is degraded by APC/C(Cdh1) during mitotic exit and G1; conversely, JNK phosphorylates Cdh1 during G2 and early mitosis, changing Cdh1 subcellular localization and reducing its ability to activate APC/C during G2/M; expression of non-degradable JNK induces prometaphase-like arrest. Co-immunoprecipitation; in vitro kinase assay (JNK phosphorylation of Cdh1); non-degradable JNK expression; subcellular localization imaging; APC/C activity assay Nature cell biology High 20581839
2013 APC/C-Cdh1 ubiquitin ligase activity is required for terminal differentiation of cortical neurons and neurogenesis in vivo; Cdh1 knockout in mouse embryos delays cell cycle exit of neural progenitors, causing replicative stress and p53-mediated apoptosis, resulting in reduced cortical neuron number and cortex size. Embryo-restricted Cdh1 knockout mouse; cortical neuron differentiation assay in vitro; in vivo cortex size measurement; p53 pathway analysis; cell cycle exit assay Nature communications High 24301314
2014 APC/C(Cdh1) controls CtIP stability during the cell cycle and after DNA damage; CtIP interacts with Cdh1 through a conserved KEN box; KEN-box mutation impedes CtIP ubiquitylation and stabilizes CtIP in G1 and after DNA damage in G2; disruption of the CtIP-Cdh1 interaction delays CtIP clearance from damage foci, increases DNA-end resection, and reduces homologous recombination efficiency. Integrated proteomics; co-immunoprecipitation; KEN-box mutagenesis; ubiquitylation assay; DNA damage foci analysis; HR efficiency assay The EMBO journal High 25349192
2014 HMGA2 epigenetically silences the Cdh1 (E-cadherin) gene during EMT by remodeling chromatin to recruit de novo DNA methyltransferase DNMT3A to the Cdh1 promoter, leading to promoter hypermethylation; CDH1 expression can be restored by treatment with the demethylating agent 5-aza-2'-deoxycytidine. Ectopic HMGA2 expression in NMuMG cells; bisulfite sequencing of Cdh1 promoter; ChIP for DNMT3A binding; 5-aza-2'-deoxycytidine rescue experiment; invasion assay Nucleic acids research Medium 25492890
2016 APC/C(Cdh1) inactivation is the commitment (point of no return) for cell-cycle entry; APC/C(Cdh1) inactivation occurs as a rapid, bistable switch shortly before DNA replication, initiated by cyclin E/Cdk2 and made irreversible by Emi1; cells exposed to stress after APC/C(Cdh1) inactivation cannot return to quiescence, while stress before inactivation can revert them. Single-cell live imaging with APC/C(Cdh1) reporter; cyclin E/Cdk2 perturbation; Emi1 depletion; stress exposure at defined cell cycle stages; flow cytometry Cell High 27368103
2016 Cdh1 promotes APC-dependent non-proteolytic monoubiquitination and transcriptional activation of the homeobox transcription factor Goosecoid (Gsc) to regulate craniofacial development; neural crest-specific Cdh1-knockout mice display domed skull, short snout, and twisted nasal bone, with reduced Gsc/Sox6 transcriptional activity. Neural crest-specific Cdh1 conditional knockout mice; ubiquitination assay of Gsc; gene expression analysis of Gsc targets; phenotypic analysis of craniofacial bones; comparison with Wwp2-deficient mice Cell research Medium 27126000
2017 APC/C(Cdh1) degrades LATS kinases to regulate Hippo signaling during the cell cycle; CDH1 recognizes LATS kinases and promotes their degradation, causing YAP/TAZ activity to peak in G1; in Drosophila, Cdh1 regulates the LATS homolog Warts through a conserved mechanism, and Cdh1 reduction increases Warts levels and decreases eye/wing size in a Yorkie-dependent manner. Co-immunoprecipitation of Cdh1-LATS interaction; LATS protein stability assay after CDH1 knockdown/overexpression; YAP/TAZ reporter assay; Drosophila genetic epistasis (Cdh1/Warts/Yorkie); cell cycle synchronization Proceedings of the National Academy of Sciences of the United States of America High 31000600
2017 APC/C(Cdh1)-mediated degradation of Rock2 (Rho kinase 2) maintains dendritic network integrity and memory formation in neurons; postnatal Cdh1 conditional knockout causes Rock2 accumulation, dendritic spine/synapse loss, memory impairment, and neurodegeneration; pharmacological inhibition of Rock activity with fasudil prevents these defects. Cdh1 conditional knockout mouse (postnatal); Rock2 ubiquitination and stability assay; dendritic morphology analysis; memory tests; fasudil pharmacological rescue; Rock2 accumulation in AD patient brain Proceedings of the National Academy of Sciences of the United States of America High 28396402
2019 Cdh1 suppresses c-Src kinase activity in an APC-independent manner; hyperactive c-Src reciprocally inhibits APC(Cdh1) E3 ligase activity by directly phosphorylating Cdh1 at its N-terminus, disrupting interaction between Cdh1 and the APC core complex; pharmacological c-Src inhibition restores APC(Cdh1) tumor suppressor function. Cdh1 depletion in breast cancer cells; co-immunoprecipitation of Cdh1-APC; in vitro kinase assay (c-Src phosphorylation of Cdh1); APC ubiquitination assay; mouse mammary tumor model with PTEN loss Nature communications High 31420536
2019 APC/C-Cdh1 promotes Skp2 ubiquitination and degradation by recognizing Skp2 after dephosphorylation at S72; dioscin attenuates Skp2 S72 phosphorylation, promoting Skp2-Cdh1 interaction and K48-linked polyubiquitination, leading to Skp2 degradation and suppression of glycolysis in colorectal cancer cells. Co-immunoprecipitation of Skp2-Cdh1; ubiquitination assay (K48 linkage); CRISPR-Cas9 Cdh1 knockout rescue experiment; Skp2 half-life assay; xenograft model EBioMedicine Medium 31806563
2019 APC/C-CDH1 targets IDH3β (isocitrate dehydrogenase 3β) for proteasomal degradation during G1; IDH3β overexpression accelerates G1-S transition and promotes cell proliferation in vitro and in vivo partly through α-ketoglutarate production and PFKFB3 upregulation. Co-immunoprecipitation of CDH1-IDH3β; IDH3β protein stability assay; cell cycle synchronization; proliferation assay; xenograft; α-KG and PFKFB3 metabolic analysis Cancer research Medium 31053633
2020 Cdh1-APC regulates protein synthesis in neurons through an FMRP-dependent mechanism; Cdh1-APC interacts with stress granule proteins including FMRP; inhibition of Cdh1-APC activity increases stress granule formation in a FMRP-dependent manner, proposing that Cdh1-APC targets stress granule proteins to inhibit their formation and promote protein synthesis. Proteomic profiling of Cdh1-APC interactome; stress granule assay upon Cdh1-APC inhibition; FMRP dependency test using knockdown; co-immunoprecipitation iScience Low 32434143
2020 In mouse oocytes, a slow-evolving DNA damage response involves APC-Cdh1-mediated proteolysis of cyclin B1 (Cdk1 activator) rather than inhibitory Cdk1 phosphorylation; this pathway requires Cdc14B-dependent APC-Cdh1 activation and is counteracted by Emi1; loss of Senataxin (Setx) causes DNA damage accumulation and APC-Cdh1-dependent G2 arrest in oocytes. Setx-deleted mouse oocytes; DNA damage induction; cyclin B1 protein level assay; Cdk1 phosphorylation assay; Cdc14B and Emi1 manipulation; G2 arrest assay The Journal of cell biology Medium 32328643
2020 The Cdh1-FoxM1-Apc axis regulates muscle development and regeneration; Cdh1 (Fzr1) is required for FoxM1 ubiquitylation and degradation in muscle satellite cells; loss of Cdh1 promotes satellite cell cycle entry and pool depletion after serial injuries; haploinsufficiency of FoxM1 ameliorates regeneration defects in Cdh1 knockout mice. Cdh1 conditional knockout in muscle satellite cells; FoxM1 ubiquitination assay; serial muscle injury model; FoxM1 haploinsufficiency rescue; gene expression analysis Cell death & disease Medium 32152291
2022 APC/C CDH1 binds and ubiquitinates STAT3 preferentially during mitosis; inhibition of phosphatases decreases STAT3 ubiquitination, suggesting that dephosphorylated STAT3 is the preferred substrate. Co-immunoprecipitation of APC/C CDH1-STAT3; ubiquitination assay across cell cycle phases; phosphatase inhibitor experiments in HEK293T cells The international journal of biochemistry & cell biology Low 36400381
2022 Amyloid-β (Aβ25-35) triggers Cdk5-mediated phosphorylation of Cdh1 in neurons, causing Cdh1 disassembly from the APC/C complex, inactivating APC/C-Cdh1, which leads to Rock2 protein stabilization and activation; a phosphodefective Cdh1 mutant prevents Aβ-induced neuronal apoptosis, while a phosphomimetic Cdh1 does not. Phosphodefective and phosphomimetic Cdh1 mutant expression; co-immunoprecipitation of Cdh1-APC/C; Rock2 stability assay; Cdk5 kinase assay; neuronal apoptosis assay in vitro and in vivo Frontiers in pharmacology Medium 35496276
2015 Casein kinase 1δ (CK1δ) is an APC/C(Cdh1) substrate; conditional deletion of Cdh1 in cerebellar granule cell progenitors results in higher CK1δ levels; APC/C(Cdh1) also downregulates CK1δ during cell-cycle exit, controlling granule cell progenitor expansion vs. differentiation. Conditional Cdh1 deletion in cerebellar GCPs; CK1δ protein level assay; CK1δ degradation assay by APC/C(Cdh1); GCP proliferation and cell-cycle exit assays Cell reports Medium 25843713

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1989 The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species. The EMBO journal 1299 2788574
1988 The role of the cell adhesion molecule uvomorulin in the formation and maintenance of the epithelial junctional complex. The Journal of cell biology 748 3049625
1990 Uvomorulin-catenin complex formation is regulated by a specific domain in the cytoplasmic region of the cell adhesion molecule. Proceedings of the National Academy of Sciences of the United States of America 747 2349235
2015 Hereditary Diffuse Gastric Cancer Syndrome: CDH1 Mutations and Beyond. JAMA oncology 523 26182300
1998 Mutations of the human E-cadherin (CDH1) gene. Human mutation 475 9744472
1985 Cell-adhesion molecule uvomorulin is localized in the intermediate junctions of adult intestinal epithelial cells. The Journal of cell biology 407 3880756
1991 The uvomorulin-anchorage protein alpha catenin is a vinculin homologue. Proceedings of the National Academy of Sciences of the United States of America 357 1924379
1992 Molecular organization of the uvomorulin-catenin complex. The Journal of cell biology 349 1734027
2008 The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpoint. Cell 334 18662541
2007 Founder and recurrent CDH1 mutations in families with hereditary diffuse gastric cancer. JAMA 327 17545690
1987 The structure of cell adhesion molecule uvomorulin. Insights into the molecular mechanism of Ca2+-dependent cell adhesion. The EMBO journal 291 3501370
1999 Germline E-cadherin gene (CDH1) mutations predispose to familial gastric cancer and colorectal cancer. Human molecular genetics 279 10072428
1985 Identification of a putative cell adhesion domain of uvomorulin. The EMBO journal 247 2419126
1987 Expression and distribution of cell adhesion molecule uvomorulin in mouse preimplantation embryos. Developmental biology 239 3315781
2000 Cell cycle- and cell growth-regulated proteolysis of mammalian CDC6 is dependent on APC-CDH1. Genes & development 231 10995389
1991 Cell-cell contacts mediated by E-cadherin (uvomorulin) restrict invasive behavior of L-cells. The Journal of cell biology 219 1649199
1990 Correct proteolytic cleavage is required for the cell adhesive function of uvomorulin. The Journal of cell biology 195 2211831
2016 Irreversible APC(Cdh1) Inactivation Underlies the Point of No Return for Cell-Cycle Entry. Cell 194 27368103
1991 Cell adhesion molecule uvomorulin expression in human breast cancer cell lines: relationship to morphology and invasive capacities. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 193 1793731
1991 Biosynthesis of the cell adhesion molecule uvomorulin (E-cadherin) in Madin-Darby canine kidney epithelial cells. The Journal of biological chemistry 192 1918074
1985 Cell-adhesion molecule uvomorulin during kidney development. Developmental biology 190 3902535
1991 Purification of a 92-kDa cytoplasmic protein tightly associated with the cell-cell adhesion molecule E-cadherin (uvomorulin). Characterization and extractability of the protein complex from the cell cytostructure. The Journal of biological chemistry 184 1999432
1990 Vectorial targeting of an endogenous apical membrane sialoglycoprotein and uvomorulin in MDCK cells. The Journal of cell biology 136 2335561
2005 Cdh1/Hct1-APC is essential for the survival of postmitotic neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience 128 16148219
1988 Characterization and chromosomal localization of the gene encoding the human cell adhesion molecule uvomorulin. Differentiation; research in biological diversity 128 3263290
2010 Hereditary diffuse gastric cancer: translation of CDH1 germline mutations into clinical practice. Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 110 20373070
2019 CDH1 (E-Cadherin) Mutation and Gastric Cancer: Genetics, Molecular Mechanisms and Guidelines for Management. Cancer management and research 108 31853199
2004 Mammalian Cdh1/Fzr mediates its own degradation. The EMBO journal 100 15029244
1991 Uvomorulin mediates calcium-dependent aggregation of islet cells, whereas calcium-independent cell adhesion molecules distinguish between islet cell types. Developmental biology 88 1936561
2010 APC/C-Cdh1: from cell cycle to cellular differentiation and genomic integrity. Cell cycle (Georgetown, Tex.) 86 20935501
2013 APC/C-Cdh1 coordinates neurogenesis and cortical size during development. Nature communications 84 24301314
1989 Uvomorulin-catenin complex: cytoplasmic anchorage of a Ca2+-dependent cell adhesion molecule. BioEssays : news and reviews in molecular, cellular and developmental biology 82 2695079
2016 CDH1 germline mutations and hereditary lobular breast cancer. Familial cancer 80 26759166
1991 The structure of the gene coding for the mouse cell adhesion molecule uvomorulin. Nucleic acids research 80 1754391
1990 A possible new adhesive site in the cell-adhesion molecule uvomorulin. Mechanisms of development 78 1710917
2019 Clinical spectrum and pleiotropic nature of CDH1 germline mutations. Journal of medical genetics 75 30661051
2019 Cdh1-mediated Skp2 degradation by dioscin reprogrammes aerobic glycolysis and inhibits colorectal cancer cells growth. EBioMedicine 75 31806563
2014 APC/C(Cdh1) controls CtIP stability during the cell cycle and in response to DNA damage. The EMBO journal 70 25349192
2003 Nuclear localization of the cell cycle regulator CDH1 and its regulation by phosphorylation. The Journal of biological chemistry 67 12560341
2013 Germline CDH1 mutations in bilateral lobular carcinoma in situ. British journal of cancer 63 24366306
2014 The high mobility group A2 protein epigenetically silences the Cdh1 gene during epithelial-to-mesenchymal transition. Nucleic acids research 59 25492890
2009 Cdh1 regulates cell cycle through modulating the claspin/Chk1 and the Rb/E2F1 pathways. Molecular biology of the cell 58 19477924
2021 Hereditary Diffuse Gastric Cancer Syndrome and the Role of CDH1: A Review. JAMA surgery 57 33404644
2017 Blepharocheilodontic syndrome is a CDH1 pathway-related disorder due to mutations in CDH1 and CTNND1. Genetics in medicine : official journal of the American College of Medical Genetics 56 28301459
2009 SNAI1 expression in colon cancer related with CDH1 and VDR downregulation in normal adjacent tissue. Oncogene 56 19802011
1986 Molecular cloning of the mouse cell adhesion molecule uvomorulin: cDNA contains a B1-related sequence. Proceedings of the National Academy of Sciences of the United States of America 55 2419906
2019 Hippo signaling is intrinsically regulated during cell cycle progression by APC/CCdh1. Proceedings of the National Academy of Sciences of the United States of America 52 31000600
2018 Cdh1 and Pik3ca Mutations Cooperate to Induce Immune-Related Invasive Lobular Carcinoma of the Breast. Cell reports 51 30332649
2012 Regulation of APC/C-Cdh1 and its function in neuronal survival. Molecular neurobiology 51 22836916
2012 Down-regulation of CDH1 is associated with expression of SNAI1 in colorectal adenomas. PloS one 50 23029563
2024 Germline CDH1 Variants and Lifetime Cancer Risk. JAMA 47 38873722
2015 ABCG2 localizes to the nucleus and modulates CDH1 expression in lung cancer cells. Neoplasia (New York, N.Y.) 47 25810011
2010 Interplay between Cdh1 and JNK activity during the cell cycle. Nature cell biology 47 20581839
1987 The role of uvomorulin in the formation of epithelial occluding junctions. Ciba Foundation symposium 47 3549195
2017 APC/CCdh1-Rock2 pathway controls dendritic integrity and memory. Proceedings of the National Academy of Sciences of the United States of America 43 28396402
2015 Deregulation of ARID1A, CDH1, cMET and PIK3CA and target-related microRNA expression in gastric cancer. Oncotarget 40 26334097
1992 Alterations in the expression of uvomorulin and Na+,K(+)-adenosine triphosphatase during mouse skin tumor progression. The American journal of pathology 40 1316085
1988 Chromosomal mapping of the structural gene coding for the mouse cell adhesion molecule uvomorulin. Proceedings of the National Academy of Sciences of the United States of America 40 2897121
2015 Expression and promoter methylation status of hMLH1, MGMT, APC, and CDH1 genes in patients with colon adenocarcinoma. Experimental biology and medicine (Maywood, N.J.) 39 25908636
2022 The Role of the APC/C and Its Coactivators Cdh1 and Cdc20 in Cancer Development and Therapy. Frontiers in genetics 35 35832196
1985 Comparison of two cell-adhesion molecules, uvomorulin and cell-CAM 105. Experimental cell research 33 3884348
1994 Junctional uvomorulin/E-cadherin and phosphotyrosine-modified protein content are correlated with paracellular permeability in Madin-Darby canine kidney (MDCK) epithelia. Histochemistry 32 7520032
1993 Cell surface localisation and stability of uvomorulin during early mouse development. Zygote (Cambridge, England) 31 8081831
2015 The role of APC/C(Cdh1) in replication stress and origin of genomic instability. Oncogene 30 26455319
2012 CDH1 gene polymorphisms, plasma CDH1 levels and risk of gastric cancer in a Chinese population. Molecular biology reports 30 22535324
2010 Association of E-cadherin (CDH1) gene polymorphisms and gastric cancer risk. World journal of gastroenterology 30 20632448
2022 Association Between Hereditary Lobular Breast Cancer Due to CDH1 Variants and Gastric Cancer Risk. JAMA surgery 29 34643667
2020 Oocytes mount a noncanonical DNA damage response involving APC-Cdh1-mediated proteolysis. The Journal of cell biology 27 32328643
2022 CDH1 (E-cadherin) Gene Methylation in Human Breast Cancer: Critical Appraisal of a Long and Twisted Story. Cancers 26 36139537
2015 Casein kinase 1δ is an APC/C(Cdh1) substrate that regulates cerebellar granule cell neurogenesis. Cell reports 26 25843713
2015 Controlling the response to DNA damage by the APC/C-Cdh1. Cellular and molecular life sciences : CMLS 26 26650195
2012 Clinical relevance of CDH1 and CDH13 DNA-methylation in serum of cervical cancer patients. International journal of molecular sciences 26 22942707
2024 Genomic and epigenomic basis of breast invasive lobular carcinomas lacking CDH1 genetic alterations. NPJ precision oncology 25 38347189
2020 A Cdh1-FoxM1-Apc axis controls muscle development and regeneration. Cell death & disease 25 32152291
2016 Cdh1 regulates craniofacial development via APC-dependent ubiquitination and activation of Goosecoid. Cell research 24 27126000
2009 Cdh1 controls the stability of TACC3. Cell cycle (Georgetown, Tex.) 24 19823035
2005 CDH1 associated gastric cancer: a report of a family and review of the literature. European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology 24 15780560
2019 Interplay between c-Src and the APC/C co-activator Cdh1 regulates mammary tumorigenesis. Nature communications 23 31420536
2021 CDH1 is Identified as A Therapeutic Target for Skin Regeneration after Mechanical Loading. International journal of biological sciences 22 33390855
2020 Cdh1-APC Regulates Protein Synthesis and Stress Granules in Neurons through an FMRP-Dependent Mechanism. iScience 21 32434143
2013 Loss of CDH1 and Pten accelerates cellular invasiveness and angiogenesis in the mouse uterus. Biology of reproduction 21 23740945
1996 Experimental manipulations of compaction and their effects on the phosphorylation of uvomorulin. Molecular reproduction and development 21 8722695
2023 CDH1 and hereditary diffuse gastric cancer: a narrative review. Chinese clinical oncology 19 37303221
2004 CDH1 germline mutation in hereditary gastric carcinoma. World journal of gastroenterology 19 15457549
2019 Total Gastrectomy for CDH-1 Mutation Carriers: An Institutional Experience. The Journal of surgical research 18 31685251
2014 Roles of E-cadherin (CDH1) genetic variations in cancer risk: a meta-analysis. Asian Pacific journal of cancer prevention : APJCP 18 24870781
2019 APC/C-CDH1-Regulated IDH3β Coordinates with the Cell Cycle to Promote Cell Proliferation. Cancer research 17 31053633
2004 Crashing waves of destruction: the cell cycle and APC(Cdh1) regulation of SCF(Skp2). Cancer cell 17 15093536
2021 Genetic and Epigenetic Alterations of CDH1 Regulatory Regions in Hereditary and Sporadic Gastric Cancer. Pharmaceuticals (Basel, Switzerland) 16 34066170
2015 DNA-PKcs Negatively Regulates Cyclin B1 Protein Stability through Facilitating Its Ubiquitination Mediated by Cdh1-APC/C Pathway. International journal of biological sciences 15 26221070
2019 MiR-9 promotes synovial sarcoma cell migration and invasion by directly targeting CDH1. The international journal of biochemistry & cell biology 14 30959202
2016 CDH1 rs9929218 variant at 16q22.1 contributes to colorectal cancer susceptibility. Oncotarget 14 27259261
1990 Altered uvomorulin expression in a noncompacting mutant cell line of F9 embryonal carcinoma cells. Developmental biology 14 2180751
2021 Frequency of CDH1 Germline Mutations in Non-Gastric Cancers. Cancers 13 34066044
2022 APC/C CDH1 ubiquitinates STAT3 in mitosis. The international journal of biochemistry & cell biology 12 36400381
2020 Characteristics of TGFBR1-EGFR-CTNNB1-CDH1 Signaling Axis in Wnt-Regulated Invasion and Migration in Lung Cancer. Cell transplantation 12 33231090
2022 Amyloid-β Induces Cdh1-Mediated Rock2 Stabilization Causing Neurodegeneration. Frontiers in pharmacology 11 35496276
2020 CDH1 gene mutation in early-onset, colorectal signet-ring cell carcinoma. Pathology, research and practice 11 32147272
2019 CDH1 and DDR1 common variants confer risk to vitiligo and autoimmune comorbidities. Gene 11 30890477
1995 Control of the surface expression of uvomorulin after activation of mouse oocytes. Zygote (Cambridge, England) 11 7582920

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