Affinage

NECTIN2

Nectin-2 · UniProt Q92692

Length
538 aa
Mass
57.7 kDa
Annotated
2026-04-29
97 papers in source corpus 33 papers cited in narrative 33 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

NECTIN2 (CD112) is an immunoglobulin superfamily cell adhesion molecule that functions at the nexus of cell-cell adhesion, immune regulation, and viral entry. Its membrane-distal V-set domain mediates Ca²⁺-independent homophilic and heterophilic trans-interactions — forming homodimers and heterodimers with nectin-3 — that are essential for adherens junction integrity at Sertoli-spermatid junctions, cardiac intercalated discs, and astrocytic perivascular endfeet, as demonstrated by knockout mice exhibiting male infertility, stress-induced cardiac dysfunction, and endfoot degeneration (PMID:10733589, PMID:12801998, PMID:19667252, PMID:27545667). The same V-domain serves as a ligand for the activating receptor DNAM-1 (CD226) and the inhibitory checkpoint receptors TIGIT and PVRIG (CD112R), with crystal structures revealing that TIGIT and PVRIG engage the nectin-2 homodimer interface to disrupt its oligomeric state, thereby competing with activating signals (PMID:12913096, PMID:28515320, PMID:38626767, PMID:40285356). NECTIN2 also functions as an entry receptor for HSV-2, HSV-1 mutants, pseudorabies virus, and HHV-6B through direct interaction of viral glycoproteins gD or gB with specific residues in its V domain, and multiple herpesviruses exploit degradation of NECTIN2 — via HCMV UL141-directed proteasomal targeting or alphaherpesvirus gD-induced downregulation — to evade DNAM-1-dependent NK cell killing (PMID:9657005, PMID:35062364, PMID:20410314, PMID:25352670). Surface expression of NECTIN2 is regulated post-translationally by ubiquitin-proteasome-mediated degradation and clathrin-dependent endocytosis, and transcriptionally by cooperative Sp1/CREB/c-Jun activity at its promoter (PMID:30888046, PMID:25046863, PMID:16250013).

Mechanistic history

Synthesis pass · year-by-year structured walk · 23 steps
  1. 1998 High

    Establishing that NECTIN2 is a herpesvirus entry receptor resolved how alphaherpesviruses other than HSV-1 gain cellular access, identifying NECTIN2 as a functional entry mediator for HSV-2, HSV-1 mutants, and pseudorabies virus.

    Evidence cDNA expression library screen in CHO cells with antibody blocking across multiple virus strains

    PMID:9657005

    Open questions at the time
    • Wild-type HSV-1 does not use NECTIN2 efficiently — the structural basis for this selectivity was unknown
    • Entry mechanism (endocytic vs. plasma membrane fusion) was undefined
  2. 1999 High

    Demonstrating that murine nectin-2 mediates PRV but not HSV entry established species-specific receptor usage and identified gD as the interacting viral glycoprotein through interference assays.

    Evidence Antibody blocking and gD co-expression interference assay in transfected cells

    PMID:10196354

    Open questions at the time
    • Structural determinants of species specificity not mapped
    • No direct binding affinity measurement
  3. 2000 High

    Knockout of nectin-2 in mice revealed an essential adhesion function at Sertoli-spermatid junctions, establishing that nectin-2 is required for spermiogenesis and male fertility through interaction with l-afadin and the actin cytoskeleton.

    Evidence Nectin-2 knockout mouse with morphological, immunolocalization, and fertility phenotyping

    PMID:10733589

    Open questions at the time
    • Mechanism of cytoskeletal disorganization not fully defined
    • Heterotypic partner on spermatids not yet identified
  4. 2000 High

    Mapping the V domain as the functional region for virus entry and showing that both splice variants (α and δ) support entry resolved which ectodomain mediates gD interaction and clarified the role of cytoplasmic tail diversity.

    Evidence Domain mapping, in vitro gD binding, and cell transfection entry assays

    PMID:10627537 PMID:10729168

    Open questions at the time
    • Precise contact residues on the V domain not yet identified
    • Entry pathway (pH-dependent vs. independent) unknown
  5. 2001 High

    Site-directed mutagenesis of the V domain identified residues 75–81 and M89 as critical determinants of HSV entry activity, providing the first residue-level map of the virus-binding site.

    Evidence Human-mouse nectin-2 chimeras and point mutagenesis with functional entry assays

    PMID:11602758

    Open questions at the time
    • No crystal structure to confirm direct contact
    • How these residues relate to nectin-nectin homophilic interfaces was unknown
  6. 2002 High

    Systematic mutagenesis of three V-domain regions showed that structural requirements for HSV entry, PRV/BHV-1 entry, and homophilic trans-interactions are separable, establishing that viral and adhesion functions use overlapping but distinct surfaces.

    Evidence Mutagenesis with entry assays for multiple alphaherpesviruses, trans-interaction, and gD binding assays

    PMID:12438620

    Open questions at the time
    • No structural data to visualize the separation of binding interfaces
    • Heterophilic nectin-3 interaction surface not mapped
  7. 2003 High

    Identification of NECTIN2 as a ligand for the NK activating receptor DNAM-1 established a direct molecular link between cell adhesion molecules and innate immune recognition of target cells.

    Evidence Protein purification/mass spectrometry, Fc-fusion binding to DNAM-1 transfectants, NK cytotoxicity assays with blocking antibodies

    PMID:12913096 PMID:15039383

    Open questions at the time
    • Binding affinity not precisely quantified
    • How homophilic nectin-2 interactions compete with DNAM-1 binding was unclear
  8. 2003 High

    Detailed analysis of Sertoli-spermatid junctions in nectin-2 null mice revealed loss of ectoplasmic specializations (espin-containing actin bundles) and identified heterotypic nectin-2/nectin-3 adhesion as the organizing interaction, explaining the infertility phenotype mechanistically.

    Evidence Knockout mouse with SEM, in vitro fertilization, LacZ reporter, and immunolocalization

    PMID:12801998

    Open questions at the time
    • Signal transduction downstream of nectin-2 in Sertoli cells not characterized
    • Whether nectin-2 loss affects blood-testis barrier integrity not tested
  9. 2006 High

    Transcriptional regulation of nectin-2 was resolved by identifying cooperative Sp1/CREB/c-Jun binding to the minimal promoter, linking adherens junction remodeling cycles in the testis to cyclic CREB expression.

    Evidence Promoter-reporter assays, EMSA, ChIP, and siRNA in testicular cells

    PMID:16250013

    Open questions at the time
    • Epigenetic regulation not addressed
    • Tissue-specific vs. ubiquitous promoter usage not resolved
  10. 2006 High

    Discovery that nectin-2-mediated HSV-1 entry proceeds via pH-independent plasma membrane fusion — unlike nectin-1-mediated endocytic entry — established that receptor identity determines the viral entry pathway.

    Evidence Endocytosis/acidification inhibitors and fusion-from-without assays in CHO-nectin-2 vs. CHO-nectin-1 cells

    PMID:17192179

    Open questions at the time
    • Mechanism by which receptor cytoplasmic domain or membrane context directs pathway choice unknown
    • Limited to one syncytial HSV-1 strain
  11. 2009 High

    Nectin-2 knockout mice subjected to pressure overload developed cardiac fibrosis and intercalated disc disruption with altered Akt/JNK/p38 signaling, revealing a cardioprotective adhesion-signaling function under stress.

    Evidence Knockout mouse with aortic banding, echocardiography, histology, and kinase phosphorylation analysis

    PMID:19667252

    Open questions at the time
    • Direct signaling cascade from nectin-2 to Akt not mapped
    • Heterotypic partner at intercalated discs not identified
  12. 2010 High

    HCMV UL141 was shown to promote proteasome-dependent degradation of surface NECTIN2, establishing a viral immune evasion mechanism that removes DNAM-1 activating ligands from infected cells.

    Evidence UL141 deletion virus, proteasome inhibitor, and flow cytometry for surface CD112

    PMID:20410314

    Open questions at the time
    • Whether UL141 directly binds nectin-2 or acts through an E3 ligase intermediate was unclear
    • Additional HCMV-encoded functions needed for full CD112 suppression not identified
  13. 2010 High

    In Xenopus neural tube morphogenesis, nectin-2 cooperates with N-cadherin through direct extracellular domain interaction to drive apical F-actin accumulation and apical constriction, establishing a developmental adhesion role independent of the intracellular afadin pathway.

    Evidence Morpholino knockdown, overexpression of domain-deleted constructs, and co-IP of extracellular domains

    PMID:20332149

    Open questions at the time
    • Direct binding affinity between nectin-2 and N-cadherin ectodomains not measured in this study
    • Whether this mechanism operates in mammalian neural tube closure untested
  14. 2012 High

    High-resolution crystal structures of the nectin-2 V-domain homodimer (1.3–1.85 Å) revealed the perpendicular dimer arrangement and showed that homodimerization is prerequisite for DNAM-1 binding, resolving how homophilic adhesion and immune ligand function are structurally coupled.

    Evidence X-ray crystallography, mutagenesis of the dimer interface, SPR, and tetramer staining

    PMID:22547693 PMID:22927415

    Open questions at the time
    • No co-crystal with DNAM-1
    • Whether heterodimer with nectin-3 also supports DNAM-1 binding untested
  15. 2013 High

    Trans-interaction of endothelial NECTIN2 with lymphocyte nectin-3 was shown to promote transendothelial migration, expanding NECTIN2's function beyond static adhesion to active leukocyte trafficking.

    Evidence Soluble receptor binding, reciprocal mAb blocking, and in vitro transendothelial migration assay

    PMID:24116228

    Open questions at the time
    • In vivo validation of this trafficking role limited
    • Signaling downstream of nectin-2 engagement on endothelium not characterized
  16. 2014 High

    Alphaherpesvirus gD was found to induce degradation of surface NECTIN2, suppressing DNAM-1-dependent NK killing — a mechanism distinct from HCMV UL141 that links viral entry glycoprotein function to immune evasion.

    Evidence Virus infection and gD transfection with flow cytometry, DNAM-1-Fc binding, and NK degranulation assays

    PMID:25352670

    Open questions at the time
    • Degradation pathway (proteasomal vs. lysosomal) for gD-induced downregulation not defined
    • Whether gD-mediated degradation affects nectin-2 adhesion functions not tested
  17. 2014 High

    Cadmium-induced nectin-2 downregulation via clathrin-dependent endocytosis and transcriptional repression (reduced Sp1/CREB promoter binding) provided a unified mechanism for toxicant-mediated blood-testis barrier disruption.

    Evidence Endocytosis inhibitors, shRNA, EMSA, ChIP, and flow cytometry

    PMID:25046863

    Open questions at the time
    • E3 ubiquitin ligase mediating cadmium-induced ubiquitination not identified
    • Direct cadmium binding to nectin-2 not tested
  18. 2016 High

    Localization of the nectin-2δ splice variant to astrocytic perivascular endfeet, and degeneration of these structures in knockout mice, established a CNS-specific adhesion role for NECTIN2 in neurovascular unit integrity.

    Evidence Knockout mouse, confocal and electron microscopy, cell-type fractionation

    PMID:27545667

    Open questions at the time
    • Whether blood-brain barrier permeability is altered in knockouts not measured
    • Heterotypic partner on endothelial side not identified
  19. 2017 High

    Crystal structures of the TIGIT:nectin-2 complex revealed that TIGIT engages the same lock-and-key interface used for nectin-nectin homodimerization, explaining how inhibitory checkpoint receptors compete with nectin homophilic adhesion and DNAM-1 binding.

    Evidence X-ray crystallography of TIGIT:nectin-2 complex, SPR (KD ~6 μM), mutagenesis, oligomer disruption assay

    PMID:27978489 PMID:28515320

    Open questions at the time
    • Functional consequence of oligomer disruption in vivo not tested
    • Whether TIGIT and DNAM-1 compete directly on the same surface unresolved structurally
  20. 2019 Medium

    Ubiquitin-proteasome-mediated intracellular retention was identified as a major regulator of NECTIN2 surface expression on tumor cells, with proteasome inhibition increasing surface levels and enhancing NK susceptibility.

    Evidence Ubiquitin pathway inhibitors, flow cytometry for surface vs. total expression, NK cytotoxicity assays

    PMID:30888046

    Open questions at the time
    • Specific E3 ligase(s) not identified
    • Whether this pathway operates in non-tumor cells not established
    • Pharmacological inhibitors may have off-target effects
  21. 2022 High

    Identification of NECTIN2 as an entry receptor for HHV-6B via V-domain interaction with gB extended the viral receptor function beyond alphaherpesviruses to a betaherpesvirus.

    Evidence CRISPR knockout, gene transduction, and pulldown of gB with nectin-2 V domain

    PMID:35062364

    Open questions at the time
    • Structural basis of gB:nectin-2 interaction not resolved
    • Whether nectin-2 is the primary or accessory receptor in vivo unclear
  22. 2024 High

    Crystal structures of the PVRIG (CD112R):NECTIN2 complex revealed an antiparallel binding mode with a double-lock-and-key mechanism, explaining PVRIG's high selectivity for NECTIN2 and its ability to disrupt NECTIN2 homodimers — completing the structural picture of the inhibitory checkpoint axis.

    Evidence X-ray crystallography of PVRIG:nectin-2 complex (including 2.2 Å structure), SPR, directed evolution of high-affinity variants, functional T cell and CAR-T assays

    PMID:38626767 PMID:40285356

    Open questions at the time
    • In vivo therapeutic efficacy of engineered CD112R variants not yet demonstrated in clinical trials
    • Whether disruption of NECTIN2 homodimers affects adhesion junctions in treated tissues unknown
  23. 2025 Medium

    ST6GalNAc-I-mediated sialylation of NECTIN2 was identified as a post-translational modification that promotes T cell dysfunction through the NECTIN2-TIGIT axis in lung adenocarcinoma, linking glycosylation to immune checkpoint activity.

    Evidence Proteomics, co-culture cytotoxicity assays, syngeneic mouse model with ST6GalNAc-I knockdown

    PMID:40371640

    Open questions at the time
    • Specific sialylation sites on NECTIN2 not mapped
    • Whether sialylation alters binding to DNAM-1 or PVRIG not tested
    • Single study awaiting independent confirmation

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key unresolved questions include: the identity of the E3 ubiquitin ligase(s) controlling NECTIN2 surface expression; the structural basis of the DNAM-1:NECTIN2 interaction (no co-crystal exists); how NECTIN2 integrates adhesion and immune signaling in the same tissue context; and the in vivo therapeutic potential of blocking NECTIN2 checkpoint interactions.
  • No DNAM-1:NECTIN2 co-crystal structure
  • E3 ligase for NECTIN2 ubiquitination unidentified
  • In vivo significance of VSIG2:NECTIN2 interaction not independently confirmed

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0098631 cell adhesion mediator activity 5 GO:0048018 receptor ligand activity 4 GO:0001618 virus receptor activity 3
Localization
GO:0005886 plasma membrane 5 GO:0005829 cytosol 1
Pathway
R-HSA-168256 Immune System 7 R-HSA-1500931 Cell-Cell communication 5 R-HSA-1643685 Disease 5
Partners
CD226CDH2MLLT4NECTIN3PVRIGTIGITVSIG2

Evidence

Reading pass · 33 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2003 Nectin-2 (CD112) was identified as a specific cell surface ligand for the NK activating receptor DNAM-1 (CD226). Protein purification, tryptic digestion, and mass spectrometry identified Nectin-2 as the 65/60 kDa molecule recognized by mAbs that blocked NK cytotoxicity. PVR-Fc and Nectin-2-Fc soluble hybrid molecules directly stained DNAM-1-transfected COS-7 cells, and Nectin-2 expression in cell transfectants enhanced NK-mediated lysis in a DNAM-1-dependent manner. Protein purification, mass spectrometry, soluble Fc-fusion binding assays, cell transfection, NK cytotoxicity assays with mAb blocking The Journal of experimental medicine High 12913096
1998 Nectin-2 (HveB/Prr2) functions as a herpesvirus entry mediator, conferring susceptibility to infection by HSV-1 mutants unable to use HVEM, HSV-2, and pseudorabies virus, but not wild-type HSV-1. Anti-HveB antibodies blocked infection of HveB-expressing cells. cDNA expression library screen in CHO cells, antibody blocking of infection, cell transfection-based entry assay Virology High 9657005
2004 DNAM-1 (CD226) functionally interacts with both CD155 (PVR) and CD112 (nectin-2) as ligands. Ectopic expression of CD112 rendered mouse T cells more susceptible to IL-2-activated T and NK cell-mediated cytotoxicity, which was inhibited by anti-CD226 mAb. Although binding affinities of soluble CD226 to CD155 and CD112 were comparable, homophilic interaction of cell-surface CD112 adversely affects CD226 binding to CD112. Cell transfection, NK/T cell cytotoxicity assays, mAb blocking, soluble receptor binding affinity measurements International immunology High 15039383
2000 Disruption of both alleles of murine nectin-2 gene resulted in sterile males with morphologically aberrant spermatozoa showing defects in nuclear and cytoskeletal morphology and mitochondrial localization. Nectin-2 interacts with l-afadin (an F-actin-binding protein) as a component of cell-cell adherens junctions and is expressed in testes only during later stages of spermatogenesis, indicating a role in late-stage germ cell development and cytoskeletal organization during spermiogenesis. Knockout mouse generation, morphological analysis, immunolocalization, genetic epistasis via null phenotype Molecular and cellular biology High 10733589
2000 Nectin-2 alpha and delta splice variants (differing in transmembrane/cytoplasmic regions but sharing ectodomain) both mediate HSV-1 mutant (carrying L25P substitution in gD) and HSV-2 entry at ~100-fold lower efficiency than HveC/HIgR. gD from HSV-1(U21) bound in vitro soluble forms of nectin-2, with weaker association than to HveC/HIgR. The major functional region for virus entry mapped to the V domain at the N-terminus. Cell transfection entry assay, in vitro gD binding assay, domain mapping Journal of virology High 10627537
2000 Nectin-2 alpha mediates direct cell-to-cell spread of HSV-1 mutant virus (carrying L25P gD substitution) but not wild-type HSV-1, consistent with its entry receptor specificity. An antibody to nectin-1 blocked cell-to-cell spread, and wild-type virus did not spread from receptor-positive to receptor-negative cells, demonstrating that Ig-like receptors (nectin-1 and nectin-2) are required for both virus entry and cell-to-cell spread. Plaque formation assay in receptor-expressing J cells, mAb blocking of spread, genetic analysis of receptor requirements Journal of virology High 10729168
2003 Loss of nectin-2 at Sertoli-spermatid junctions causes male infertility. Nectin-2-deficient spermatozoa show severe head and midpiece malformations, 4-fold reduced migration to oviducts, 6-fold reduced binding to zona-intact oocytes, and failure to penetrate zona-free hamster oocytes. Sertoli-spermatid junctions in nectin-2-null mice lack the actin-bundling protein espin, indicating ectoplasmic specializations fail to form. Nectin-2 is produced exclusively by Sertoli cells and forms a heterotypic adhesion complex with nectin-3 on elongated spermatids. Knockout mouse (LacZ knockin), scanning electron microscopy, in vitro fertilization assays, LacZ reporter expression analysis, immunolocalization Biology of reproduction High 12801998
2001 Specific amino acid sequences in the V domain of human nectin-2 are critical for HSV entry activity. Chimeric molecules between human and mouse nectin-2 showed that replacing amino acids 75-81 or residue 89 of mouse nectin-2 with human residues transferred HSV-1/Rid and HSV-2 entry activity. Replacement of residue 89 of human nectin-2 (M89F) eliminated HSV entry activity. This region is homologous to the HIV-binding region of CD4 and the poliovirus-binding region of CD155. Chimeric receptor construction, cell transfection entry assay, mutagenesis Journal of virology High 11602758
2003 N-terminal sequences of HSV gD govern functional interactions with nectin-2, HVEM, and 3-O-sulfated heparan sulfate, but are not required for nectin-1 interactions. Deletions overlapping HVEM contact regions (aa 7-15 and 24-32) severely reduced cell fusion and binding with all receptors except nectin-1. L25P, Q27P, and Q27R substitutions in HSV-1 gD enhanced fusion with human nectin-2 (ordinarily low for wt HSV-1 gD) while the same substitutions in HSV-2 gD were without effect on the already high fusion level. Cell fusion assay, soluble gD:Fc binding to receptor-expressing cells, mutagenesis (substitutions and deletions in gD N-terminus) Journal of virology High 12915538
2010 Human cytomegalovirus UL141 promotes downregulation of CD112 (nectin-2) via proteasome-mediated degradation by 48 h post-infection, thereby removing both DNAM-1 activating ligands (CD155 and CD112) from the cell surface. UL141 alone is sufficient to retain CD155 in the ER, but requires additional HCMV-encoded functions to suppress CD112 expression. HCMV infection with UL141 deletion mutant, proteasome inhibitor treatment, flow cytometry for surface expression, genetic rescue with UL141 deletion The Journal of general virology High 20410314
2012 Crystal structure of the nectin-2 V-set domain (nectin-2v) at 1.85 Å resolution reveals a perpendicular homodimer arrangement. Disruption of the homodimeric interface by mutagenesis abolished homodimer formation and simultaneously eliminated DNAM-1 binding, indicating that homodimerization or engagement of the homodimeric interface is required for DNAM-1 interaction. X-ray crystallography (1.85 Å), mutagenesis, surface plasmon resonance, tetramer cell staining, biochemical characterization Journal of immunology High 22547693
2012 Crystal structure of the nectin-2 homodimer at 1.3 Å resolution reveals the structural basis for homophilic and heterophilic interactions. Mutagenesis of charged residues at the dimer interface identifies them as major determinants of binding affinities, and provides mechanistic explanation for stronger heterophilic versus weaker homophilic interactions among nectin family members. X-ray crystallography (1.3 Å), complementary mutagenesis, biochemical binding assays Proceedings of the National Academy of Sciences High 22927415
2010 Nectin-2 physically interacts with N-cadherin through their extracellular domains, and they cooperatively enhance apical constriction by driving F-actin accumulation at apical cell surfaces during Xenopus neural tube morphogenesis. The intracellular afadin-binding motif of nectin-2 was not required for ectopic apical constriction induction. Nectin-2 knockdown impaired neural fold formation by attenuating F-actin accumulation, while overexpression in non-neural ectoderm induced ectopic apical constrictions. Xenopus morpholino knockdown, overexpression of domain-deleted nectin-2, co-immunoprecipitation of extracellular domains, live imaging of F-actin Development High 20332149
2017 TIGIT binds to the membrane-distal V-set immunoglobulin domain of nectin-2 with an affinity of 6 μM. Crystal structure of TIGIT bound to the first Ig domain of nectin-2 showed that TIGIT and nectin-2 dock using the same molecular surface (lock-and-key binding motif) used in nectin/nectin homotypic interactions. TIGIT/nectin-2 binding disrupts pre-assembled nectin-2 oligomers. Mutagenesis identified an 'aromatic key' of nectin-2 as critical for TIGIT interaction, while the C-C' loop of nectin-2 dictates the TIGIT binding hierarchy. X-ray crystallography of TIGIT:nectin-2 complex, SPR binding affinity measurements, mutagenesis, disruption of nectin-2 oligomers assay The Journal of biological chemistry High 28515320
2016 TIGIT engages nectin-2 using a canonical immunoglobulin-like dimer interface. Biophysical studies showed TIGIT is monomeric in solution but dimerizes at high concentrations. Biochemical mutagenesis mapped the nectin-2 binding interface on TIGIT, defining the structural and biochemical determinants for TIGIT:nectin-2 recognition. X-ray crystallography of TIGIT ectodomain, biophysical characterization (SPR), mutagenesis, model of TIGIT:nectin-2 complex Molecular immunology High 27978489
2006 DNAM-1 (CD226) and its ligand Nectin-2 (CD112) are expressed on human mast cells and eosinophils. Engagement of CD226 on mast cells augments FcεRI-dependent degranulation through a pathway involving Fyn, LAT, PLCγ2, and CD18. This costimulatory pathway is completely inhibited by IRp60 (CD300a) inhibitory receptor. Blocking CD112 on eosinophils normalized the hyperactivation of mast cells co-cultured with eosinophils. Flow cytometry, mAb stimulation/blocking, degranulation assay, inhibitor analysis of signaling pathway, co-culture with blocking antibodies The Journal of biological chemistry Medium 16831868
2009 Nectin-2 deficiency in mice leads to cardiac fibrosis and dysfunction under chronic pressure overload (ascending aorta banding) but not under physiological conditions. In banded nectin-2 knockout mice, intercalated discs were disrupted, myofibrils disorganized, and cardiac myocyte apoptosis increased. Akt phosphorylation remained lower, while JNK and p38 MAPK were hyperphosphorylated compared to wild-type, revealing nectin-2-dependent signaling for cardiac protection. Knockout mouse, ascending aorta banding model, echocardiography, histology, immunoblotting for signaling kinases, TUNEL assay Hypertension High 19667252
2013 Nectin-3 (CD113) expressed on T lymphocytes trans-interacts with Nectin-2 (CD112) on endothelial cells at high endothelial venules to promote lymphocyte transendothelial migration. A soluble form of Nectin-3 binds to Nectin-2 at EC junctions, and blocking Nectin-2 trans-interactions with mAbs abolished soluble Nectin-3 binding. Blocking either Nectin-3 on lymphocytes or Nectin-2 on ECs inhibited lymphocyte extravasation in vitro. Soluble receptor binding assay, mAb blocking of trans-interactions, in vitro transendothelial migration assay PloS one High 24116228
2014 The alphaherpesvirus gD glycoprotein (from PRV and HSV-2) induces degradation and downregulation of CD112 (nectin-2) from the cell surface during infection or transfection, reducing DNAM-1 binding to infected/transfected cells and suppressing NK cell degranulation and lysis. This identifies a previously uncharacterized alphaherpesvirus NK evasion strategy. Virus infection/transfection, flow cytometry for surface CD112, DNAM-1-Fc binding assay, NK cell degranulation and cytotoxicity assays Proceedings of the National Academy of Sciences High 25352670
2016 Nectin-2 (CD112) regulates endothelial cell biology in vivo: CD112-deficient mice show enhanced blood vessel coverage in retina and spleen. In vitro, CD112 blockade enhanced endothelial tube formation and cell migration. CD112 knockdown enhanced tube formation, cell migration, and proliferation with p-Erk activation, and led to compensatory upregulation of Nectin-3 and Necl-4 which promote VEGFR signaling. CD112 also regulates T cell entry into the spleen in vivo. CD112-knockout mice, retinal and spleen vasculature analysis, in vitro tube formation and migration assays, siRNA knockdown, flow cytometry, signaling analysis PloS one Medium 27676263
2019 Ubiquitination of Nectin2 promotes its intracellular retention and proteasomal degradation, limiting surface expression. Inhibition of the ubiquitin-proteasome pathway results in increased Nectin2 surface expression and enhances tumor cell susceptibility to NK cell cytotoxicity. Nectin2 is predominantly expressed in cytoplasmic pools on tumor cell lines. Ubiquitin pathway inhibitors, flow cytometry for surface vs. total expression, NK cell cytotoxicity assays, subcellular fractionation European journal of immunology Medium 30888046
2016 Nectin-2δ splice variant is selectively expressed in astrocytes and localizes to perivascular astrocytic endfoot processes facing blood vessel basement membranes, while nectin-2α is expressed in both neurons and astrocytes. Genetic ablation of nectin-2 caused degeneration of astrocytic perivascular endfoot processes and neurons in the cerebral cortex, revealing a critical role for nectin-2 in brain homeostasis. Nectin-2 knockout mouse, immunofluorescence, confocal microscopy, cell-type specific fractionation, electron microscopy of endfoot processes Brain research High 27545667
2006 Nectin-2 gene transcription in testicular cells is controlled by cooperative interaction of Sp1, CREB, and AP-1 (c-Jun) transcription factors. The minimal mouse nectin-2 promoter (nucleotides -316 to -211) contains two Sp1 motifs and one CRE motif that synergize to regulate transcription. In vivo, CREB, c-Jun, and Sp1 family proteins are bound to the nectin-2 promoter. Cyclic expression of CREB coincides with adherens junction restructuring between Sertoli cells and germ cells. Transient transfection/promoter reporter assay, EMSA, chromatin immunoprecipitation (ChIP), siRNA knockdown, overexpression Journal of cellular physiology High 16250013
2014 Cadmium suppresses nectin-2 expression at both transcriptional and post-translational levels in testicular cells. Cadmium induces nectin-2 protein degradation via clathrin-dependent endocytosis, promotes nectin-2 internalization, and directly represses nectin-2 transcription by inhibiting binding of positive transcriptional regulators (Sp1, CREB) to the nectin-2 promoter, contributing to blood-testis barrier disruption. Endocytosis inhibitors, shRNA knockdown, siRNA, immunofluorescence, EMSA, ChIP, flow cytometry-based endocytosis assay Biochimica et biophysica acta High 25046863
2018 Nectin-2 directly interacts with the extracellular domain of N-cadherin with a KD of 3.5 ± 0.6 μM, as demonstrated by surface plasmon resonance. Structural analysis of homodimeric structures and molecular docking identified the binding interface. This provides a direct, adaptor-independent mechanism by which nectins can recruit cadherins to sites of adherens junction. Surface plasmon resonance (SPR), structural analysis of existing crystal structures, molecular docking, complementary mutagenesis Proteins Medium 30183103
2022 Nectin-2 acts as a viral entry mediator for Human Herpesvirus 6B (HHV-6B). Nectin-2-transduced T cells became permissive for HHV-6B infection, and nectin-2 knockout in parotid-derived HSY cells significantly reduced HHV-6B entry. HHV-6B glycoprotein B (gB) interacted specifically with the nectin-2 V-set domain. Nectin-2 gene transduction into T cells, nectin-2 knockout via CRISPR, virus infection assays, pulldown/binding assay between gB and nectin-2 V-set domain Viruses High 35062364
2024 Crystal structure of the PVRIG (CD112R):Nectin-2 complex at undisclosed resolution identified a unique CC' loop in PVRIG that complements a double-lock-and-key binding mode and contributes to its high affinity for Nectin-2. Charged residues in the F-strands explain PVRIG selectivity for Nectin-2 over Necl-5. CD112R was found to disrupt CD112 homodimerization in an antiparallel binding mode. X-ray crystallography of PVRIG:Nectin-2 complex, comparative binding affinity measurements, structural analysis Structure High 38626767
2025 Crystal structure of the CD112:CD112R (Nectin-2:PVRIG) complex at 2.2 Å resolution reveals an antiparallel, lock-and-key binding mode in which CD112R disrupts CD112 homodimerization. Structure-guided directed evolution produced CD112R mutants with increased CD112 binding affinity; the highest-affinity variant (CD112RIVE) potently inhibits CD112-CD112R interactions as a soluble trap. X-ray crystallography (2.2 Å), directed evolution, SPR binding affinity measurement, functional T cell activation and cytotoxicity assays with CAR-T and T cell engager constructs Molecular therapy High 40285356
2002 Mutations in three equivalent regions of the N-terminal V-like domain of nectin-2 revealed distinct structural requirements for HSV entry, PRV/BHV-1 entry, and homotypic/heterotypic nectin-nectin trans-interactions. Region I mutations (impairing HSV entry) did not reduce homotypic trans-interactions for nectin-2. Region III mutations that reduced homotypic trans-interactions of nectin-2 also impaired PRV and BHV-1 entry activity. Effects on gD binding did not necessarily correlate with functional entry. Mutagenesis of nectin-2 V domain, cell transfection entry assay with multiple alphaherpesvirus strains, binding assay to gD Journal of virology High 12438620
2025 ST6GalNAc-I sialylates NECTIN2 in lung adenocarcinoma cells, as shown by proteomic and biochemical analysis. This sialylation promotes T cell dysfunction via the NECTIN2-TIGIT axis. ST6GalNAc-I-deficient tumor cells co-cultured with T cells were more susceptible to T cell-mediated killing, and mice injected with St6galnac-I-knockdown cells showed reduced Nectin2/Tigit-associated immunosuppression. Proteomics, biochemical co-localization, syngeneic mouse model, KD/KO co-culture cytotoxicity assay The Journal of clinical investigation Medium 40371640
2006 Nectin-2-mediated HSV-1 ANG path (syncytial strain) entry into CHO cells occurs via pH-independent fusion at the plasma membrane, whereas nectin-1 directs the same strain to a pH-dependent endocytic pathway. HSV-1 ANG path virions induced rapid fusion-from-without (FFWO) exclusively in CHO-nectin-2 cells, not in CHO-nectin-1 or receptor-negative cells, demonstrating that receptor identity (nectin-2 vs. nectin-1) determines the entry pathway. Endocytosis/acidification inhibitors, kinetics of entry measurement, FFWO assay, CHO cell transfectants expressing distinct receptors Virology journal High 17192179
1999 Murine nectin-2 (mHveB), the mouse homolog of human HveB, mediates entry of porcine pseudorabies virus (PRV) but not HSV-1 or HSV-2. Anti-mHveB antibody and soluble mHveB ectodomain inhibited mHveB-dependent PRV entry. Co-expression of mHveB with PRV gD (but not HSV-1 gD) caused interference with entry, suggesting direct interaction of PRV gD with mHveB during viral entry. Cell transfection entry assay, antibody blocking, interference assay with viral gD co-expression, RT-PCR Journal of virology High 10196354
2021 VSIG2 specifically binds to Nectin-2 (and not to PD-1 or CTLA-4) and functions as an immunosuppressive ligand present on antigen-presenting cells. VSIG2-Nectin-2 binding strongly inhibits T cell activation and proliferation. This interaction regulates the STAT1/IRF1/GBP2 signaling pathway in T cells. Direct binding assay (VSIG2 vs. known immune receptors), co-culture T cell activation/proliferation assays, signaling pathway analysis, in vivo mouse EAE model, anti-tumor assay Journal of neuroinflammation Medium 41350674

Source papers

Stage 0 corpus · 97 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2003 Identification of PVR (CD155) and Nectin-2 (CD112) as cell surface ligands for the human DNAM-1 (CD226) activating molecule. The Journal of experimental medicine 706 12913096
1998 A cell surface protein with herpesvirus entry activity (HveB) confers susceptibility to infection by mutants of herpes simplex virus type 1, herpes simplex virus type 2, and pseudorabies virus. Virology 416 9657005
2004 Analysis of the receptor-ligand interactions in the natural killer-mediated lysis of freshly isolated myeloid or lymphoblastic leukemias: evidence for the involvement of the Poliovirus receptor (CD155) and Nectin-2 (CD112). Blood 313 15536144
2004 Functional characterization of DNAM-1 (CD226) interaction with its ligands PVR (CD155) and nectin-2 (PRR-2/CD112). International immunology 226 15039383
2005 Expression of the DNAM-1 ligands, Nectin-2 (CD112) and poliovirus receptor (CD155), on dendritic cells: relevance for natural killer-dendritic cell interaction. Blood 214 16304049
1995 The human PRR2 gene, related to the human poliovirus receptor gene (PVR), is the true homolog of the murine MPH gene. Gene 163 7622062
1999 Effect of environmental pH on morphological development of Candida albicans is mediated via the PacC-related transcription factor encoded by PRR2. Journal of bacteriology 146 10601210
2000 Defects in nuclear and cytoskeletal morphology and mitochondrial localization in spermatozoa of mice lacking nectin-2, a component of cell-cell adherens junctions. Molecular and cellular biology 143 10733589
2000 Nectin2alpha (PRR2alpha or HveB) and nectin2delta are low-efficiency mediators for entry of herpes simplex virus mutants carrying the Leu25Pro substitution in glycoprotein D. Journal of virology 122 10627537
2005 PVR (CD155) and Nectin-2 (CD112) as ligands of the human DNAM-1 (CD226) activating receptor: involvement in tumor cell lysis. Molecular immunology 116 15607800
2003 Loss of nectin-2 at Sertoli-spermatid junctions leads to male infertility and correlates with severe spermatozoan head and midpiece malformation, impaired binding to the zona pellucida, and oocyte penetration. Biology of reproduction 105 12801998
2003 Mutations in the N termini of herpes simplex virus type 1 and 2 gDs alter functional interactions with the entry/fusion receptors HVEM, nectin-2, and 3-O-sulfated heparan sulfate but not with nectin-1. Journal of virology 98 12915538
2000 Cell-to-cell spread of wild-type herpes simplex virus type 1, but not of syncytial strains, is mediated by the immunoglobulin-like receptors that mediate virion entry, nectin1 (PRR1/HveC/HIgR) and nectin2 (PRR2/HveB). Journal of virology 94 10729168
2010 Human cytomegalovirus UL141 promotes efficient downregulation of the natural killer cell activating ligand CD112. The Journal of general virology 91 20410314
2013 Nectin-2 is a potential target for antibody therapy of breast and ovarian cancers. Molecular cancer 86 23758976
2017 Recognition of nectin-2 by the natural killer cell receptor T cell immunoglobulin and ITIM domain (TIGIT). The Journal of biological chemistry 81 28515320
2000 Dominant active alleles of RIM101 (PRR2) bypass the pH restriction on filamentation of Candida albicans. Molecular and cellular biology 78 10848590
2024 Integrative analysis of neuroblastoma by single-cell RNA sequencing identifies the NECTIN2-TIGIT axis as a target for immunotherapy. Cancer cell 75 38181797
1997 The prpR1 and prR2 arginine-specific protease genes of Porphyromonas gingivalis W50 produce five biochemically distinct enzymes. Molecular microbiology 75 9076732
2010 Nectin-2 and N-cadherin interact through extracellular domains and induce apical accumulation of F-actin in apical constriction of Xenopus neural tube morphogenesis. Development (Cambridge, England) 65 20332149
2006 Mast cell costimulation by CD226/CD112 (DNAM-1/Nectin-2): a novel interface in the allergic process. The Journal of biological chemistry 61 16831868
2012 Crystal structure of cell adhesion molecule nectin-2/CD112 and its binding to immune receptor DNAM-1/CD226. Journal of immunology (Baltimore, Md. : 1950) 53 22547693
1999 The murine homolog (Mph) of human herpesvirus entry protein B (HveB) mediates entry of pseudorabies virus but not herpes simplex virus types 1 and 2. Journal of virology 51 10196354
2012 Structure of Nectin-2 reveals determinants of homophilic and heterophilic interactions that control cell-cell adhesion. Proceedings of the National Academy of Sciences of the United States of America 49 22927415
2001 Structural features of nectin-2 (HveB) required for herpes simplex virus entry. Journal of virology 47 11602758
2021 The CD112R/CD112 axis: a breakthrough in cancer immunotherapy. Journal of experimental & clinical cancer research : CR 46 34507594
2014 Modulation of CD112 by the alphaherpesvirus gD protein suppresses DNAM-1-dependent NK cell-mediated lysis of infected cells. Proceedings of the National Academy of Sciences of the United States of America 46 25352670
2006 Nectin-2-mediated entry of a syncytial strain of herpes simplex virus via pH-independent fusion with the plasma membrane of Chinese hamster ovary cells. Virology journal 44 17192179
2020 Nectin-2 Expression on Malignant Plasma Cells Is Associated with Better Response to TIGIT Blockade in Multiple Myeloma. Clinical cancer research : an official journal of the American Association for Cancer Research 43 32513837
2019 Nectin-2 in ovarian cancer: How is it expressed and what might be its functional role? Cancer science 41 30843637
2015 The Clinical and Pathological Significance of Nectin-2 and DDX3 Expression in Pancreatic Ductal Adenocarcinomas. Disease markers 40 26294807
2019 The Ubiquitin-proteasome pathway regulates Nectin2/CD112 expression and impairs NK cell recognition and killing. European journal of immunology 37 30888046
2020 Candidate Gene Analysis Reveals That the Fruit Color Locus C1 Corresponds to PRR2 in Pepper (Capsicum frutescens). Frontiers in plant science 35 32328078
2002 Mutations in the N-terminal domains of nectin-1 and nectin-2 reveal differences in requirements for entry of various alphaherpesviruses and for nectin-nectin interactions. Journal of virology 35 12438620
2024 Tumor-associated neutrophils upregulate Nectin2 expression, creating the immunosuppressive microenvironment in pancreatic ductal adenocarcinoma. Journal of experimental & clinical cancer research : CR 32 39261943
2018 Differential Induction of IFN-α and Modulation of CD112 and CD54 Expression Govern the Magnitude of NK Cell IFN-γ Response to Influenza A Viruses. Journal of immunology (Baltimore, Md. : 1950) 32 30143589
2006 Nectin-2 expression in testicular cells is controlled via the functional cooperation between transcription factors of the Sp1, CREB, and AP-1 families. Journal of cellular physiology 32 16250013
2013 Nectin-3 (CD113) interacts with Nectin-2 (CD112) to promote lymphocyte transendothelial migration. PloS one 31 24116228
2009 Deficiency of nectin-2 leads to cardiac fibrosis and dysfunction under chronic pressure overload. Hypertension (Dallas, Tex. : 1979) 29 19667252
2024 Colorectal cancer-associated fibroblasts inhibit effector T cells via NECTIN2 signaling. Cancer letters 28 38821255
2021 Nectin-2 in general and in the brain. Molecular and cellular biochemistry 28 34633611
1998 Maturation of the arginine-specific proteases of Porphyromonas gingivalis W50 is dependent on a functional prR2 protease gene. Infection and immunity 26 9529086
2016 Localization of nectin-2δ at perivascular astrocytic endfoot processes and degeneration of astrocytes and neurons in nectin-2 knockout mouse brain. Brain research 24 27545667
2016 Structural, mutational and biophysical studies reveal a canonical mode of molecular recognition between immune receptor TIGIT and nectin-2. Molecular immunology 23 27978489
2003 Differences in the N termini of herpes simplex virus type 1 and 2 gDs that influence functional interactions with the human entry receptor Nectin-2 and an entry receptor expressed in Chinese hamster ovary cells. Journal of virology 23 12915581
2018 Elevated Nectin-2 expression is involved in esophageal squamous cell carcinoma by promoting cell migration and invasion. Oncology letters 22 29552112
2019 Serum nectin-2 and nectin-4 are diagnostic in lung cancer: which is superior? Wiener klinische Wochenschrift 21 31440821
2014 Increased CD112 expression in methylcholanthrene-induced tumors in CD155-deficient mice. PloS one 20 25384044
2021 CD155 and CD112 as possible therapeutic targets of FLT3 inhibitors for acute myeloid leukemia. Oncology letters 18 34992684
2004 The herpes simplex virus JMP mutant enters receptor-negative J cells through a novel pathway independent of the known receptors nectin1, HveA, and nectin2. Journal of virology 18 15078954
2022 Nectin-2 Acts as a Viral Entry Mediated Molecule That Binds to Human Herpesvirus 6B Glycoprotein B. Viruses 17 35062364
2016 Nectin-2 (CD112) Is Expressed on Outgrowth Endothelial Cells and Regulates Cell Proliferation and Angiogenic Function. PloS one 16 27676263
2021 Lipid-related protein NECTIN2 is an important marker in the progression of carotid atherosclerosis: An intersection of clinical and basic studies. Journal of translational internal medicine 15 35136728
2017 PRR2, a pseudo-response regulator, promotes salicylic acid and camalexin accumulation during plant immunity. Scientific reports 15 28765536
2024 Immune checkpoint molecule DNAM-1/CD112 axis is a novel target for natural killer-cell therapy in acute myeloid leukemia. Haematologica 14 37731380
2014 Dysregulation of nectin-2 in the testicular cells: an explanation of cadmium-induced male infertility. Biochimica et biophysica acta 14 25046863
2021 CD112 Regulates Angiogenesis and T Cell Entry into the Spleen. Cells 13 33467729
2019 Specific TCP transcription factors interact with and stabilize PRR2 within different nuclear sub-domains. Plant science : an international journal of experimental plant biology 13 31481190
2018 Molecular and structural bases of interaction between extracellular domains of nectin-2 and N-cadherin. Proteins 13 30183103
2024 The SNP rs6859 in NECTIN2 gene is associated with underlying heterogeneous trajectories of cognitive changes in older adults. BMC neurology 12 38408961
2022 A Novel Antibody-Drug Conjugate Targeting Nectin-2 Suppresses Ovarian Cancer Progression in Mouse Xenograft Models. International journal of molecular sciences 12 36293219
2025 ST6GalNAc-I regulates tumor cell sialylation via NECTIN2/MUC5AC-mediated immunosuppression and angiogenesis in non-small cell lung cancer. The Journal of clinical investigation 11 40371640
2005 Expression of nectin-2 in mouse granulosa cells. European journal of obstetrics, gynecology, and reproductive biology 11 15989986
2002 The poliovirus receptor related 2 (PRR2) and apolipoprotein E genes and coronary heart disease. Journal of cardiovascular risk 11 11984219
2022 Examination of the TIGIT-CD226-CD112-CD155 Immune Checkpoint Network during a Healthy Pregnancy. International journal of molecular sciences 9 36142692
2021 Examination of the TIGIT, CD226, CD112, and CD155 Immune Checkpoint Molecules in Peripheral Blood Mononuclear Cells in Women Diagnosed with Early-Onset Preeclampsia. Biomedicines 9 34829838
2001 Search for polymorphisms in the genes for herpesvirus entry mediator, nectin-1, and nectin-2 in immune seronegative individuals. The Journal of infectious diseases 9 11756979
2024 Exercise-induced β2-adrenergic Receptor Activation Enhances the Antileukemic Activity of Expanded γδ T-Cells via DNAM-1 Upregulation and PVR/Nectin-2 Recognition. Cancer research communications 8 38592213
2023 Nectin2 influences cell apoptosis by regulating ANXA2 expression in neuroblastoma. Acta biochimica et biophysica Sinica 8 36916296
2017 Comparison of the antiviral potential among soluble forms of herpes simplex virus type-2 glycoprotein D receptors, herpes virus entry mediator A, nectin-1 and nectin-2, in transgenic mice. The Journal of general virology 8 28671524
2024 N6-methyladenosine-associated genetic variants in NECTIN2 and HPCAL1 are risk factors for abdominal aortic aneurysm. iScience 7 38510151
2023 Extracellular CIRP Induces Novel Nectin-2+ (CD112+) Neutrophils to Promote Th1 Differentiation in Sepsis. Journal of immunology (Baltimore, Md. : 1950) 7 36480269
2016 Accumulation of a soluble form of human nectin-2 is required for exerting the resistance against herpes simplex virus type 2 infection in transfected cells. Acta virologica 7 26982466
2024 The association between rs6859 in NECTIN2 gene and Alzheimer's disease is partly mediated by pTau. Frontiers in aging neuroscience 6 39165837
2018 Fc engineering of anti-Nectin-2 antibody improved thrombocytopenic adverse event in monkey. PloS one 6 29723247
2024 Structural basis for the immune recognition and selectivity of the immune receptor PVRIG for ligand Nectin-2. Structure (London, England : 1993) 5 38626767
2024 Blockade of the TIGIT-CD155/CD112 axis enhances functionality of NK-92 but not cytokine-induced memory-like NK cells toward CD155-expressing acute myeloid leukemia. Cancer immunology, immunotherapy : CII 4 38967649
2022 Proline-Rich Region II (PRR2) Plays an Important Role in Tau-Glycan Interaction: An NMR Study. Biomolecules 4 36358923
2010 [Expression of CD112 in colon carcinoma tissues and cell lines and their clinical significance]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 4 20617580
2022 Analysis of Protein-Protein Interactions Identifies NECTIN2 as a Target of N,N-Bis (5-Ethyl-2-hydroxybenzyl) Methylamine for Inhibition of Lung Cancer Metastasis. Cancer genomics & proteomics 3 35985690
2015 A soluble form of human nectin-2 impairs exocrine secretion of pancreas and formation of zymogen granules in transgenic mice. Biochemistry and biophysics reports 3 28955824
2009 Molecular cloning, characterization and three-dimensional modeling of porcine nectin-2/CD112. Veterinary immunology and immunopathology 3 19497625
2024 CD112 Supports Lymphatic Migration of Human Dermal Dendritic Cells. Cells 2 38474388
2021 Analysis of whole genome sequenced cases and controls shows that the association of variants in TOMM40, BCAM, NECTIN2 and APOC1 with late onset Alzheimer's disease is driven by linkage disequilibrium with APOE ε2/ε3/ε4 alleles. Journal of neurogenetics 2 33970751
2025 Structure-guided engineering of CD112 receptor variants for optimized immunotherapy. Molecular therapy : the journal of the American Society of Gene Therapy 1 40285356
2024 CD112 is an epithelial-to-mesenchymal transition-related and immunological biomarker in pan-cancer. Translational cancer research 1 38881943
2023 Relative Expression of BATF and CD112 in PBMC of Patients with Chronic Lymphocytic Leukemia. Asian Pacific journal of cancer prevention : APJCP 1 37378949
2017 Polioviruses that bind a chimeric Pvr-nectin-2 protein identify capsid residues involved in receptor interaction. Virology 1 28800489
2026 A novel CD112-derived peptide targeting gut-primed neutrophils to attenuate deadly hepatic injury. Molecular medicine (Cambridge, Mass.) 0 41703450
2026 Lower hippocampal volume partly mediates the association between rs6859 in the NECTIN2 gene and Alzheimer's disease: new findings from causal mediation analysis of ADNI data. Frontiers in aging neuroscience 0 41757361
2025 Investigation of TIGIT, PVRIG, CD112 and CD155 expression in early and late onset preeclampsia. Journal of molecular histology 0 40425968
2025 Laryngeal Squamous Cell Carcinoma Is Characterized by a Stronger Expression of Nectin-4 Compared to Nectin-2. Current issues in molecular biology 0 40699695
2025 Lower Hippocampal Volume Partly Mediates the Association Between rs6859 in the NECTIN2 Gene and Alzheimer's Disease: New Findings from Causal Mediation Analysis of ADNI Data. medRxiv : the preprint server for health sciences 0 40950481
2025 VSIG2 as a novel immunosuppressive ligand interacts with Nectin-2 to regulate T cell responses. Journal of neuroinflammation 0 41350674
2024 The association between rs6859 in NECTIN2 gene and Alzheimer's disease is partly mediated by pTau. medRxiv : the preprint server for health sciences 0 38947013
2009 Crystallization and preliminary X-ray analysis of the V domain of human nectin-2. Acta crystallographica. Section F, Structural biology and crystallization communications 0 19478445
2007 [Preparation and characterization of monoclonal antibodies against human CD112 (Nectin2/PRR2)]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 0 17428395