Affinage

NECTIN3

Nectin-3 · UniProt Q9NQS3

Length
549 aa
Mass
61.0 kDa
Annotated
2026-04-29
42 papers in source corpus 24 papers cited in narrative 23 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

NECTIN3 is a Ca²⁺-independent immunoglobulin-like cell adhesion molecule that forms cis-homodimers and engages in heterophilic trans-interactions with nectin-1, nectin-2, and Necl-5/CD155 through its V domain, linking cell-cell contacts to the actin cytoskeleton and cadherin-based adherens junctions via its cytoplasmic PDZ-binding motif that directly binds afadin (PMID:10744716, PMID:25534554). In the testis, nectin-3 on spermatids trans-interacts with nectin-2 on Sertoli cells to maintain Sertoli–spermatid junctions essential for spermatogenesis, and nectin-3-deficient mice are male-infertile with distorted sperm morphology (PMID:16923130). In the hippocampus and prefrontal cortex, nectin-3 is required for dendritic spine maintenance and memory; chronic stress triggers NMDA receptor–dependent MMP-9 cleavage of nectin-3 downstream of CRH–CRHR1 signaling, causing spine loss and cognitive impairment (PMID:23644483, PMID:25232752). Nectin-3 also mediates tissue-specific adhesion in the ciliary epithelium, cochlear organ of Corti (acting downstream of PCP/Vangl2 signaling to guide spiral ganglion neuron axon turning), and tooth enamel organ, and serves as a cell-surface receptor for Clostridioides difficile toxin B on colonocytes (PMID:15728677, PMID:24381198, PMID:40207531, PMID:37747247).

Mechanistic history

Synthesis pass · year-by-year structured walk · 13 steps
  1. 2000 High

    Establishing that nectin-3 is a homophilic and heterophilic adhesion molecule that links to afadin and cadherin-based junctions resolved the question of whether nectin-3 could function as a Ca²⁺-independent cell adhesion receptor integrated into adherens junctions.

    Evidence Cell-based adhesion assays, co-immunoprecipitation, and immunofluorescence colocalization in transfected cells

    PMID:10744716 PMID:11024295

    Open questions at the time
    • Structural basis of nectin-3 cis-dimerization and trans-interactions not resolved
    • In vivo function of nectin-3 not yet tested with genetic models
  2. 2002 High

    Mapping the nectin-1/nectin-3 heterophilic interface to V-domain beta-strands with nanomolar affinity established the molecular basis for their preferential trans-interaction over homophilic binding.

    Evidence Surface plasmon resonance and competition binding with chimeric receptors and monoclonal antibodies

    PMID:12011057

    Open questions at the time
    • Atomic-resolution crystal structure of the nectin-1/nectin-3 trans-dimer not yet available
    • Relative contribution of C domains to in vivo function unknown
  3. 2003 High

    Identification of Necl-5/CD155 as a heterophilic trans-partner for nectin-3 expanded the nectin interactome beyond the nectin family and linked nectin-3 to cell motility regulation in Ras-transformed cells.

    Evidence Cell-based ligand binding assays, heterologous co-culture, and immunofluorescence in multiple independent studies

    PMID:12740392 PMID:12759359

    Open questions at the time
    • Structural basis of the nectin-3/Necl-5 interaction undetermined
    • Relevance of this interaction to normal (non-transformed) physiology unclear
  4. 2005 High

    Demonstration that nectin-3/Necl-5 trans-interaction triggers clathrin-dependent endocytosis of Necl-5, reducing proliferation and migration, established nectin-3 as a mediator of contact inhibition of cell growth.

    Evidence Clathrin inhibition, cell migration and proliferation assays in NIH3T3 cells

    PMID:16216929

    Open questions at the time
    • Signaling intermediates between nectin-3 engagement and clathrin recruitment not identified
    • Whether this mechanism operates in epithelial tissues in vivo not tested
  5. 2005 High

    Nectin-3 knockout mice revealed that heterophilic nectin-1/nectin-3 trans-interaction is required for junction formation in the ciliary epithelium, providing the first in vivo genetic evidence for nectin-3 function in tissue morphogenesis.

    Evidence Nectin-3−/− mice with microphthalmia, immunofluorescence and immunoelectron microscopy

    PMID:15728677

    Open questions at the time
    • Molecular mechanism linking nectin-3 loss to junction disassembly not dissected
    • Whether redundancy with other nectins limits phenotypic severity unknown
  6. 2006 High

    Discovery that nectin-3 on spermatids trans-interacts with nectin-2 on Sertoli cells, and that nectin-3−/− mice are male-infertile, established nectin-3 as essential for spermatid adhesion and maturation.

    Evidence Nectin-3−/− mice, spermatogenic stem cell transplantation rescue, immunohistochemistry

    PMID:16923130

    Open questions at the time
    • How nectin-3 loss leads to mitochondrial mislocalization and nuclear distortion mechanistically unresolved
    • Identity of downstream signaling pathways at the apical ectoplasmic specialization not fully defined
  7. 2010 High

    Compound nectin-1;nectin-3 mutant mice showed that heterophilic nectin-1/nectin-3 interaction recruits desmosomes to ameloblast–stratum intermedium junctions, broadening nectin-3's role from adherens to desmosomal junction assembly.

    Evidence Compound knockout mice, immunohistochemistry, electron microscopy of tooth enamel organ

    PMID:21038445

    Open questions at the time
    • Mechanism by which nectin trans-interaction nucleates desmosome assembly not identified
    • Whether other tooth developmental pathways are affected independently of desmosomes unknown
  8. 2013 High

    Placing nectin-3 downstream of CRH–CRHR1 signaling in the hippocampus, and showing that nectin-3 manipulation bidirectionally controls stress-induced spine loss and memory deficits, identified nectin-3 as a synaptic effector of stress.

    Evidence AAV-mediated knockdown/overexpression in mice, CRHR1 genetic inactivation, CRH overexpression, behavioral and spine analysis

    PMID:23644483

    Open questions at the time
    • Intracellular signaling cascade from CRHR1 activation to nectin-3 downregulation not fully delineated
    • Whether afadin is co-regulated with nectin-3 in this context not established
  9. 2014 High

    Identification of MMP-9 as the protease that cleaves nectin-3 in hippocampal CA1 in an NMDA receptor–dependent manner explained how chronic stress removes nectin-3 from perisynaptic sites to impair cognition.

    Evidence MMP-9 knockout/pharmacological inhibition, NMDA receptor blockade, gelatinase activity assay, behavioral testing

    PMID:25232752

    Open questions at the time
    • Exact cleavage site on nectin-3 not mapped
    • Fate of the cleaved ectodomain (shed fragment signaling) not investigated
  10. 2014 High

    Nectin-3 deficiency in cochlear hair cells caused aberrant hair cell–hair cell contacts, disrupted hair bundle orientation, and mislocalized polarity proteins, revealing nectin-3 as a determinant of planar cell polarity in the inner ear.

    Evidence Nectin-3-deficient mice, immunofluorescence and confocal microscopy of cochlear epithelium

    PMID:24381198

    Open questions at the time
    • Upstream signals controlling nectin-3 expression in hair cells not identified at this point
    • Whether nectin-3 directly interacts with polarity proteins or acts indirectly unknown
  11. 2015 High

    The crystal structure of the afadin PDZ domain bound to the nectin-3 C-terminal peptide revealed the atomic basis for their interaction, including a conformational widening of the binding groove, resolving how nectin-3 is physically linked to the cytoskeleton.

    Evidence X-ray crystallography of AFPDZ–nectin-3 fusion protein complex

    PMID:25534554

    Open questions at the time
    • Structure of full-length nectin-3 or the nectin-3/afadin complex beyond the PDZ interface not available
    • Regulation of the PDZ interaction (phosphorylation, competition) not structurally characterized
  12. 2023 Medium

    Discovery that nectin-3 localizes to the colonocyte brush border and serves as a receptor for C. difficile toxin B extended nectin-3 biology from developmental adhesion to pathogen entry.

    Evidence Immunofluorescence microscopy on colonic tissue, receptor localization studies

    PMID:37747247

    Open questions at the time
    • Binding interface between TcdB and nectin-3 not structurally resolved
    • Whether other nectin family members can substitute as TcdB receptors not tested
    • Functional consequence of TcdB binding on nectin-3 adhesion function not examined
  13. 2025 Medium

    Placing nectin-3 downstream of PCP/Vangl2 signaling and in the same genetic pathway as Rac1 for spiral ganglion neuron axon turning unified nectin-3's adhesive role with planar polarity-guided axon guidance in the cochlea.

    Evidence Conditional knockout mice, genetic epistasis analysis, afferent turning phenotype quantification

    PMID:40207531

    Open questions at the time
    • How Vangl2 transcriptionally or post-transcriptionally regulates nectin-3 expression not determined
    • Whether Rac1 acts upstream or downstream of nectin-3-mediated adhesion not resolved
    • Role of afadin in this cochlear guidance pathway not examined

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key unresolved questions include the full-length structural basis of nectin-3 cis- and trans-dimeric assemblies, the intracellular signaling cascades immediately downstream of nectin-3 engagement, the MMP-9 cleavage site and function of the shed ectodomain, and whether nectin-3 plays roles in immune cell biology beyond lymphocyte transendothelial migration.
  • No full-length or trans-dimer crystal structure available
  • Downstream signaling immediately triggered by nectin-3 ligation largely undefined
  • Shed ectodomain biology unexplored

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0098631 cell adhesion mediator activity 6 GO:0001618 virus receptor activity 1
Localization
GO:0005886 plasma membrane 6 GO:0005634 nucleus 1 GO:0005829 cytosol 1
Pathway
R-HSA-1500931 Cell-Cell communication 6 R-HSA-1266738 Developmental Biology 5 R-HSA-112316 Neuronal System 4 R-HSA-1474165 Reproduction 3
Partners
AFDNCADM1MMP9NECTIN1NECTIN2PVRVANGL2
Complex memberships
nectin-afadin complex

Evidence

Reading pass · 23 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2000 Nectin-3 (nectin-3alpha) forms cis-homodimers and shows Ca2+-independent trans-homo-interaction causing homophilic cell-cell adhesion; it also shows trans-hetero-interaction with nectin-1 and nectin-2 (but not cis-heterodimerization). Nectin-3alpha interacts with afadin (an actin filament-binding protein) via its C-terminal PDZ-binding motif and co-localizes with nectin-2 at cadherin-based adherens junctions. Cell-based adhesion assays, co-immunoprecipitation, immunofluorescence colocalization The Journal of biological chemistry High 10744716
2000 Human nectin-3/PRR3 carries the C-terminal A/EXYV consensus motif and interacts in vivo with both long and short isoforms of afadin, identifying it as an afadin-associated adhesion molecule at intercellular junctions. Co-immunoprecipitation (in vivo interaction assay), SDS-PAGE, expression analysis Gene Medium 11024295
2002 Nectin-3 trans-hetero-interacts with nectin-1 through V-domain to V-domain contacts (KD ~1 nM), with the C-C'-C"-D beta-strands of the nectin-1 V domain constituting the minimal binding region; C domains contribute to increased binding affinity. Surface plasmon resonance (affinity measurements), competition binding assays with monoclonal antibodies, chimeric receptor mapping (nectin1/PVR chimeras) The Journal of biological chemistry High 12011057
2003 Nectin-3 heterophilically trans-interacts with Necl-5/Tage4/CD155 (but not homophilically); this interaction recruits nectin-3 to cell-cell contact sites and promotes cell motility of Ras-transformed cells. CD155 was found to co-distribute with αv integrin microdomains. Cell-based ligand binding assays, heterologous co-culture, immunofluorescence colocalization, co-immunoprecipitation The Journal of biological chemistry High 12740392 12759359
2004 Upon cell-cell contact, Necl-5 trans-interaction with nectin-3 recruits afadin, E-cadherin, and catenins to the nectin-3 side of contact sites (not the Necl-5 side), and blocking this interaction inhibits E-cadherin-based adherens junction formation. Stable cell line expression of Necl-5/nectin-3/E-cadherin in L cells, anti-Necl-5 blocking antibody, immunofluorescence Genes to cells Medium 15330856
2005 Nectin-1 and nectin-3 localize at apex-apex junctions between pigment and non-pigment cell layers of the ciliary epithelia; heterophilic trans-interaction between nectin-1 and nectin-3 is required for formation of these junctions and for normal ciliary body morphogenesis, as demonstrated by microphthalmia and junction separation in nectin-3-/- mice. Genetic knockout (nectin-3-/- mice), immunofluorescence, immunoelectron microscopy Development (Cambridge, England) High 15728677
2005 Necl-5 interaction with nectin-3 upon cell-cell contact triggers clathrin-dependent endocytosis of Necl-5, leading to its downregulation from the cell surface, which in turn reduces cell movement and proliferation — a mechanism underlying contact inhibition. Immunofluorescence, clathrin inhibition, cell migration and proliferation assays in NIH3T3 cells The Journal of cell biology High 16216929
2006 Nectin-3 localizes asymmetrically to the spermatid side of Sertoli-spermatid junctions and its heterophilic trans-interaction with nectin-2 (on the Sertoli cell side) is essential for Sertoli-spermatid junction formation and spermatid development; nectin-3-/- mice show male-specific infertility, distorted sperm nuclei, abnormal mitochondrial distribution, and mislocalization of nectin-2. Spermatogenic stem cell transplantation partially rescues the defects. Genetic knockout (nectin-3-/- mice), spermatogenic stem cell transplantation, immunohistochemistry Genes to cells High 16923130
2010 Heterophilic interaction between nectin-1 (in ameloblasts) and nectin-3 (in stratum intermedium cells) recruits desmosomal junctions between these cell types, which are required for proper enamel formation and crown shape development in mouse teeth. Double knockout mice (nectin-1;nectin-3 compound mutants), immunohistochemistry, electron microscopy Developmental dynamics High 21038445
2012 CADM1 on mast cells binds heterophilically to nectin-3 expressed on dorsal root ganglion (DRG) neurons; this heterophilic interaction mediates mast cell attachment to DRG neurites and the subsequent calcium responses, as shown by neutralizing antibody blockade of nectin-3. Neutralizing antibody blockade, calcium imaging, cell attachment assay Journal of neuroimmunology Medium 22703826
2012 sFRP1 regulates spermatid adhesion at the apical ectoplasmic specialization by controlling FAK-Tyr397 phosphorylation; dephosphorylation of FAK by sFRP1 leads to retention of nectin-3 at the apical ES and delayed spermiation. Overexpression of sFRP1 in Sertoli-germ cell coculture confirmed that sFRP1 controls nectin-3 phosphorylation and localization downstream of FAK signaling. In vivo sFRP1 recombinant protein administration, lentiviral overexpression in Sertoli-germ cell coculture, Western blotting for phospho-FAK, immunolocalization of nectin-3 FASEB journal Medium 23073828
2013 Hippocampal nectin-3 is required for stress-induced structural plasticity and memory: suppression of hippocampal nectin-3 causes spatial memory deficits and dendritic spine loss, while enhancing nectin-3 rescues early-life stress-induced memory deficits and spine loss. The CRH-CRHR1 signaling pathway (but not glucocorticoid receptors) regulates nectin-3 levels, acting via the nectin-afadin complex. AAV-mediated knockdown/overexpression in mice, CRHR1 genetic inactivation, CRH overexpression in forebrain neurons, behavioral testing, spine density analysis Nature neuroscience High 23644483
2013 Nectin-3 expressed on T lymphocytes trans-interacts with nectin-2 expressed on endothelial cells (particularly at high endothelial venules); blocking either nectin-3 on lymphocytes or nectin-2 on endothelial cells with monoclonal antibodies inhibits lymphocyte transendothelial migration in vitro. Blocking monoclonal antibodies, soluble nectin-3 binding assay, transendothelial migration assay PloS one Medium 24116228
2014 MMP-9 proteolytically cleaves nectin-3 in the hippocampal CA1 perisynaptic compartment following chronic restraint stress; this cleavage requires NMDA receptor activity. Loss of nectin-3 in CA1 (but not CA3) mediates stress-induced social and cognitive behavioral alterations. Gelatinase activity assay, NMDA receptor inhibition, MMP-9 knockout/inhibition, behavioral testing, western blotting Nature communications High 25232752
2014 Nectin-3 deficiency in cochlear hair cells causes aberrant HC-HC contacts instead of normal HC-SC contacts, leading to disturbances in hair bundle orientation and morphology, kinocilium positioning, and abnormal localization of cadherin-catenin complexes and polarity proteins Pals1 and Par-3. Nectin-3-deficient mice, immunofluorescence, confocal microscopy Development (Cambridge, England) High 24381198
2015 Crystal structure of the afadin PDZ domain (AFPDZ) in complex with the nectin-3 C-terminal peptide reveals that: the last three amino acids of the nectin-3 C-terminus (class II PDZ-binding motif, X-Φ-X-Φ) are sufficient for binding; the AFPDZ undergoes a conformational change (~2.5 Å wider ligand-binding groove in α2 helix) compared to unbound structures; the complex crystallizes as a dimer via antiparallel β-sheet between β2 strands. X-ray crystallography (crystal structure of AFPDZ-nectin-3 fusion protein complex) Protein science High 25534554
2016 In rat uterine epithelial cells, nectin-3 redistributes from basal cytoplasm to cell junctions at the time of implantation (day 6 of pregnancy), a process likely controlled by progesterone. At this junctional location, nectin-3 does not interact with occludin or l-afadin, suggesting a protein complex independent of canonical AJ components. Immunofluorescence, Western blotting, coimmunoprecipitation Reproductive sciences Medium 27217376
2017 Nectin-3 knockdown in all dentate gyrus (DG) neuron populations impairs long-term spatial memory and temporal order memory, and modulates differentiation/maturation of adult-born DG granule cells; selective knockdown in new DG neurons reduces dendritic spine density (especially thin spines) and impairs long-term spatial memory. AAV-mediated and retroviral nectin-3 knockdown in DG neurons, behavioral testing, dendritic spine analysis, immunofluorescence for neurogenesis markers Translational psychiatry High 28872640
2017 Nectin-3 (an adhesion junction protein from the spermatid plasma membrane) is internalized via tubulobulbar complexes in the testis; immunoelectron microscopy localizes nectin-3 labeling at junctions, at tubulobulbar complex bulbs (identified by dual plasma membrane and ER association), and in associated double-membrane vesicles, indicating clathrin/actin-mediated endocytic internalization of junction proteins. Pre-embedding immunoelectron microscopy Anatomical record Medium 28176461
2020 ZNF582 directly regulates the transcription and expression of nectin-3; ZNF582 binds the nectin-3 promoter (ChIP-seq/ChIP-qPCR/luciferase assay), and ZNF582 restoration suppresses NPC migration/invasion while knockdown of nectin-3 reverses this tumor-suppressive effect. ChIP-seq, ChIP-qPCR, luciferase reporter assay, siRNA knockdown, in vitro migration/invasion assays, in vivo xenograft Cancer communications Medium 33038291
2020 Nectin-3 knockdown in the medial prefrontal cortex (mPFC) of adolescent mice reproduces stress-induced impairments in social recognition memory, spatial working memory, dendritic simplification, and reduced spine density; membrane localization of nectin-3 in mPFC correlates with behavioral performance. AAV-mediated nectin-3 knockdown, behavioral testing, dendritic morphology analysis, subcellular fractionation/western blotting Neuroscience bulletin Medium 32385776
2023 Nectin-3, in addition to its adherens junction localization, localizes to the brush border of colonocytes and can function as a cell-surface receptor for Clostridioides difficile toxin B (TcdB), allowing toxin access to colonic epithelial cells. Immunofluorescence microscopy on colonic tissue, receptor localization studies mBio Medium 37747247
2025 Nectin-3 in cochlear supporting cells (SCs) is regulated by PCP signaling (via Vangl2) and is required for proper type II spiral ganglion neuron (SGNII) peripheral afferent turning; loss of Nectin-3 partially phenocopies Vangl2 mutant turning defects, and epistasis analysis places Nectin-3 and Rac1 in the same genetic pathway controlling SGNII axon guidance. Mouse genetics (conditional KO), genetic epistasis analysis, in vivo afferent turning phenotype quantification Development (Cambridge, England) Medium 40207531

Source papers

Stage 0 corpus · 42 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2000 Nectin-3, a new member of immunoglobulin-like cell adhesion molecules that shows homophilic and heterophilic cell-cell adhesion activities. The Journal of biological chemistry 247 10744716
2002 Prominent role of the Ig-like V domain in trans-interactions of nectins. Nectin3 and nectin 4 bind to the predicted C-C'-C"-D beta-strands of the nectin1 V domain. The Journal of biological chemistry 118 12011057
2003 Tage4/Nectin-like molecule-5 heterophilically trans-interacts with cell adhesion molecule Nectin-3 and enhances cell migration. The Journal of biological chemistry 114 12740392
2013 Nectin-3 links CRHR1 signaling to stress-induced memory deficits and spine loss. Nature neuroscience 108 23644483
2014 Role for MMP-9 in stress-induced downregulation of nectin-3 in hippocampal CA1 and associated behavioural alterations. Nature communications 106 25232752
2005 Roles of cell-adhesion molecules nectin 1 and nectin 3 in ciliary body development. Development (Cambridge, England) 99 15728677
2005 Inhibition of cell movement and proliferation by cell-cell contact-induced interaction of Necl-5 with nectin-3. The Journal of cell biology 90 16216929
2004 Nectin-like molecule-5/Tage4 enhances cell migration in an integrin-dependent, Nectin-3-independent manner. The Journal of biological chemistry 87 14871893
2006 Role of cell adhesion molecule nectin-3 in spermatid development. Genes to cells : devoted to molecular & cellular mechanisms 82 16923130
2003 Recruitment of nectin-3 to cell-cell junctions through trans-heterophilic interaction with CD155, a vitronectin and poliovirus receptor that localizes to alpha(v)beta3 integrin-containing membrane microdomains. The Journal of biological chemistry 71 12759359
2000 Human nectin3/PRR3: a novel member of the PVR/PRR/nectin family that interacts with afadin. Gene 60 11024295
2017 Nectin-3 modulates the structural plasticity of dentate granule cells and long-term memory. Translational psychiatry 36 28872640
2010 Cooperation of nectin-1 and nectin-3 is required for normal ameloblast function and crown shape development in mouse teeth. Developmental dynamics : an official publication of the American Association of Anatomists 36 21038445
2018 Nectin-3 is a new biomarker that mediates the upregulation of MMP2 and MMP9 in ovarian cancer cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 33 30469078
2013 The expression of the Nectin complex in human breast cancer and the role of Nectin-3 in the control of tight junctions during metastasis. PloS one 32 24386110
2013 Nectin-3 (CD113) interacts with Nectin-2 (CD112) to promote lymphocyte transendothelial migration. PloS one 31 24116228
2020 ZNF582 hypermethylation promotes metastasis of nasopharyngeal carcinoma by regulating the transcription of adhesion molecules Nectin-3 and NRXN3. Cancer communications (London, England) 29 33038291
2014 Aberrant cochlear hair cell attachments caused by Nectin-3 deficiency result in hair bundle abnormalities. Development (Cambridge, England) 28 24381198
2019 Anti-quorum sensing and antibiofilm activities of Blastobotrys parvus PPR3 against Pseudomonas aeruginosa PAO1. Microbial pathogenesis 24 31644930
2012 Cell adhesion molecule 1 (CADM1) on mast cells promotes interaction with dorsal root ganglion neurites by heterophilic binding to nectin-3. Journal of neuroimmunology 24 22703826
2012 Secreted Frizzled-related protein 1 (sFRP1) regulates spermatid adhesion in the testis via dephosphorylation of focal adhesion kinase and the nectin-3 adhesion protein complex. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 24 23073828
2004 Involvement of heterophilic trans-interaction of Necl-5/Tage4/PVR/CD155 with nectin-3 in formation of nectin- and cadherin-based adherens junctions. Genes to cells : devoted to molecular & cellular mechanisms 22 15330856
2017 Loss of ppr3, ppr4, ppr6, or ppr10 perturbs iron homeostasis and leads to apoptotic cell death in Schizosaccharomyces pombe. The FEBS journal 21 27886462
2020 Prefrontal Nectin3 Reduction Mediates Adolescent Stress-Induced Deficits of Social Memory, Spatial Working Memory, and Dendritic Structure in Mice. Neuroscience bulletin 19 32385776
2013 Tauopathy differentially affects cell adhesion molecules in mouse brain: early down-regulation of nectin-3 in stratum lacunosum moleculare. PloS one 18 23704923
2006 Expression of nectin-1, nectin-3, N-cadherin, and NCAM in spinal motoneurons after sciatic nerve transection. Experimental neurology 15 16777094
2017 High Resolution Localization of Rab5, EEA1, and Nectin-3 to Tubulobulbar Complexes in the Rat Testis. Anatomical record (Hoboken, N.J. : 2007) 13 28176461
2015 Crystal structure of afadin PDZ domain-nectin-3 complex shows the structural plasticity of the ligand-binding site. Protein science : a publication of the Protein Society 13 25534554
2019 Postnatal nectin-3 knockdown induces structural abnormalities of hippocampal principal neurons and memory deficits in adult mice. Hippocampus 12 31066147
2015 A new method for detection of tumor driver-dependent changes of protein sialylation in a colon cancer cell line reveals nectin-3 as TGFBR2 target. Protein science : a publication of the Protein Society 12 26177744
2009 Nectin-3 expression is elevated in limbal epithelial side population cells with strongly expressed stem cell markers. Biochemical and biophysical research communications 10 19716807
2023 Nectin-3 and shed forms of CSPG4 can serve as epithelial cell receptors for Clostridioides difficile TcdB. mBio 9 37747247
2020 Precise levels of nectin-3 are required for proper synapse formation in postnatal visual cortex. Neural development 9 33160402
2019 Loss of nectin-3 expression as a marker of tumor aggressiveness in pancreatic neuroendocrine tumor. Pathology international 9 31855317
2016 Nectin-3 Is Increased in the Cell Junctions of the Uterine Epithelium at Implantation. Reproductive sciences (Thousand Oaks, Calif.) 7 27217376
2018 Disruption of ppr3, ppr4, ppr6 or ppr10 induces flocculation and filamentous growth in Schizosaccharomyces pombe. FEMS microbiology letters 5 29878109
2024 Dorsal CA1 NECTIN3 Reduction Mediates Early-Life Stress-Induced Object Recognition Memory Deficits in Adolescent Female Mice. Neuroscience bulletin 4 39395912
2025 Rac1 and Nectin3 are essential for planar cell polarity-directed axon guidance in the peripheral auditory system. Development (Cambridge, England) 2 40207531
2024 Rac1 and Nectin3 are essential for PCP-directed axon guidance in the peripheral auditory system. bioRxiv : the preprint server for biology 1 38895287
2022 Evidence that Nectin-3 is the soybean agglutinin binding protein on rat corneal endothelium cell surfaces. Experimental eye research 1 35964705
2025 Early-life stress of limited bedding/nesting material induced recognition memory loss and decreased hippocampal VGluT1 and nectin3 levels in aged male mice. Pharmacology, biochemistry, and behavior 0 39987993
2025 The VP5 protein of the oncolytic virus OH2 regulates nectin-3 molecule to modulate tumor cell apoptosis. Virology 0 40446441