Affinage

CDH2

Cadherin-2 · UniProt P19022

Length
906 aa
Mass
99.8 kDa
Annotated
2026-06-09
60 papers in source corpus 23 papers cited in narrative 23 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

CDH2 (N-cadherin) is a Ca2+-dependent homophilic cell-cell adhesion molecule whose extracellular HAV-domain-mediated interactions assemble adherens junctions required for tissue integrity and morphogenesis across multiple developmental contexts (PMID:23965744, PMID:37166408). Its adhesive function underpins the blood-testis barrier, where Sertoli-cell-specific loss disrupts basal ectoplasmic specializations, delays meiosis, and reduces sperm output (PMID:25631347), and it controls cortical development by maintaining radial-glia adherens junctions that restrain progenitor proliferation and ensure proper lamination (PMID:25100583). Beyond static adhesion, CDH2 couples to actomyosin contractility to drive tissue shape change, acting upstream of Myosin-II during neural plate internalisation (PMID:30755665). In the segmentation clock, CDH2 is a direct transcriptional target of Hes7 and operates upstream of FGF signalling to sustain oscillations (PMID:40951951), and in stem cells it stabilizes FGFR1 to support FGF-dependent self-renewal (PMID:26420260) while promoting neural differentiation (PMID:23416351). In neurons CDH2 organizes presynaptic vesicle clustering and dopaminergic neurotransmission, and a maturation-impairing missense mutation causes familial ADHD (PMID:34702855). CDH2 also transduces intracellular signals by binding the PI3K subunits p85α and p110 to restrain Akt–β-catenin signalling [PMID:bio_10.1101_2025.10.22.683948]. Its expression is regulated transcriptionally by FOXF1 (PMID:29642003), AP-1/Junb (PMID:37119763), GATA2/MZF1 downstream of endothelin-1 (PMID:31194009), and MEG3/EP300 (PMID:35697159), and is silenced by DNMT1-mediated promoter methylation (PMID:38357662), while its mRNA translation is controlled by ALKBH5-dependent m6A modification read by IGF2BP1/2/3 and YTHDF1 (PMID:36418936).

Mechanistic history

Synthesis pass · year-by-year structured walk · 10 steps
  1. 2013 Medium

    Established that CDH2-based adherens junctions, acting through the HAV homophilic interface, are required for epithelial cell survival rather than adhesion alone, and that CDH2 levels gate neural differentiation.

    Evidence HAV-domain blocking peptides in vivo with TUNEL readout; gain- and loss-of-function in mouse iPSCs with differentiation assays

    PMID:23416351 PMID:23965744

    Open questions at the time
    • Mechanism linking junction disruption to apoptosis not defined
    • Downstream effectors of CDH2 in differentiation not identified
  2. 2014 High

    Showed CDH2 restrains progenitor proliferation and enforces cortical lamination by maintaining radial-glia adherens junctions, linking adhesion to proliferation control.

    Evidence Conditional knockout in dorsal telencephalon with BrdU proliferation and histology, plus afadin co-inactivation

    PMID:25100583

    Open questions at the time
    • Signalling pathway coupling junction loss to hyperproliferation not resolved
    • How dispersed progenitors generate band heterotopia unclear
  3. 2015 High

    Defined CDH2 as a required structural component of the blood-testis barrier and as a stabilizer of FGFR1 supporting FGF-dependent stem-cell self-renewal, extending its role from adhesion to receptor regulation.

    Evidence Sertoli-cell conditional KO with BTB and meiosis readouts; reciprocal Co-IP and knockdown in mEpiSCs

    PMID:25631347 PMID:26420260

    Open questions at the time
    • Structural basis of CDH2–FGFR1 interaction unknown
    • Whether FGFR1 stabilization underlies BTB or differentiation roles untested
  4. 2018 High

    Identified FOXF1 as a direct transcriptional regulator that controls a CDH2-to-CDH11 cadherin switch governing myofibroblast invasion, establishing transcriptional control of CDH2 with functional consequences.

    Evidence Promoter ChIP, FOXF1 conditional KO mouse, CDH2 re-expression rescue, invasion assay

    PMID:29642003

    Open questions at the time
    • How cadherin identity dictates invasive phenotype mechanistically unclear
  5. 2019 Medium

    Expanded the regulatory landscape of CDH2 transcription and showed that point variants disrupt adhesion function, linking CDH2 to morphogenesis and disease.

    Evidence Promoter assays with mutagenesis identifying GATA2/MZF1 downstream of EDN1/EDNRA; L1 fibroblast aggregation assay of the p.Val289Ile hypopituitarism variant; zebrafish Myosin-II internalisation analysis

    PMID:30755665 PMID:31194009 PMID:37166408

    Open questions at the time
    • Whether adhesion defect alone explains hypopituitarism not established
    • Molecular link between CDH2 and Myosin-II distribution undefined
  6. 2021 High

    Provided causal genetic evidence that a CDH2 maturation-impairing mutation causes ADHD via defective presynaptic vesicle clustering and dopaminergic deficits, defining a synaptic function for CDH2.

    Evidence CRISPR/Cas9 knock-in mouse with behavior, electrophysiology, dopamine quantification and methylphenidate rescue; ARTN/p44-42 MAPK epistasis in colorectal cancer

    PMID:34422665 PMID:34702855

    Open questions at the time
    • How impaired maturation produces vesicle-clustering defect not resolved
    • Connection between adhesion and dopaminergic signalling unclear
  7. 2022 High

    Established post-transcriptional control of CDH2 through m6A modification and demonstrated a direct requirement for CDH2 in cancer cell motility.

    Evidence m6A-seq, RIP-qPCR, polysome fractionation and Alkbh5-KO mouse with ultrastructure; CRISPR KO in 4T1 cells with migration assay

    PMID:35890278 PMID:36418936

    Open questions at the time
    • Whether translational and adhesive roles of CDH2 are separable in cancer untested
    • Site-specific m6A residues on Cdh2 mRNA not mapped
  8. 2023 High

    Positioned CDH2 within the segmentation clock as a direct Hes7 target acting upstream of FGF signalling, and identified AP-1/Junb as a direct promoter activator.

    Evidence Hes7 ChIP-seq, Cdh2 KO/overexpression in ESC-derived PSM with live Hes7 oscillation imaging; ChIP-qPCR and luciferase mutagenesis for Junb

    PMID:37119763 PMID:40951951

    Open questions at the time
    • How CDH2 feeds back to modulate FGF signalling mechanistically unknown
    • Relationship between CDH2 protein gradient and oscillatory output unresolved
  9. 2024 Medium

    Showed epigenetic silencing of CDH2 via PCDH9-ICD-stimulated DNMT1 promoter methylation suppresses gastric cancer metastasis, adding a methylation-based regulatory layer.

    Evidence Co-IP, DNMT1 activity assay, bisulfite sequencing of CDH2 promoter, rescue and in vivo metastasis model

    PMID:38357662

    Open questions at the time
    • Whether CDH2 loss is necessary versus correlative for metastasis suppression unclear
  10. 2025 Low

    Proposed a signalling output for CDH2 in which it binds PI3K subunits to restrain Akt-β-catenin signalling, and implicated trafficking and adhesion-complex partners, extending CDH2 beyond junctional adhesion.

    Evidence Co-IP of CDH2 with p85α/p110, PI3K and promoter assays in osteoblast-like cells (preprint); zebrafish Ndrg1b recycling study (preprint); DSG2/CDH2 interactome by BioID-MS identifying JUP and PKP2 (preprint)

    PMID:bio_10.1101_2025.05.08.652902 PMID:bio_10.1101_2025.06.09.658637 PMID:bio_10.1101_2025.10.22.683948

    Open questions at the time
    • PI3K-restraint model from a single preprint without independent confirmation
    • Trafficking and intercalated-disc partner claims lack direct CDH2 binding validation

Open questions

Synthesis pass · forward-looking unresolved questions
  • How CDH2's adhesive, mechanotransductive, receptor-stabilizing, and signalling functions are integrated within a single tissue context remains unresolved.
  • No structural model unifying CDH2 binding to FGFR1, PI3K, and junctional partners
  • Whether intracellular signalling roles are conserved beyond bone/cancer cells untested

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0008092 cytoskeletal protein binding 2 GO:0098631 cell adhesion mediator activity 2
Localization
GO:0005856 cytoskeleton 2 GO:0005886 plasma membrane 2
Pathway
R-HSA-1266738 Developmental Biology 2 R-HSA-1500931 Cell-Cell communication 2 R-HSA-162582 Signal Transduction 2
Partners
DSG2FGFR1JUPPIK3CAPIK3R1PKP2
Complex memberships
adherens junction

Evidence

Reading pass · 23 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2015 CDH2 (N-cadherin) stabilizes FGFR1 in mouse epiblast stem cells (mEpiSCs), contributing to FGF signaling-dependent self-renewal; co-immunoprecipitation revealed direct interaction between CDH2 and FGFR1, and CDH2 knockdown attenuated pluripotency-related gene expression while CDH1 overexpression could not rescue this effect. Co-immunoprecipitation, siRNA knockdown, western blot, stable transfection Scientific reports Medium 26420260
2015 Conditional knockout of Cdh2 specifically in Sertoli cells (but not germ cells) compromised blood-testis barrier function, delayed meiotic progression from prophase to metaphase I, increased germ cell apoptosis, and reduced sperm counts, establishing CDH2 as a functionally required component of basal ectoplasmic specializations at the blood-testis barrier. Conditional knockout (Cdh2 loxP × Amh-Cre mice), BTB integrity assay, histology, TUNEL assay Biology of reproduction High 25631347
2013 Selective disruption of CDH2-based adherens junctions using peptides that interfere with the histidine-alanine-valine (HAV) extracellular homophilic interaction domain caused disruption of zonula adherens, abnormal intracellular accumulation of N-cadherin, massive apoptosis of ependymal cells, and denudation of brain ventricular walls, demonstrating that CDH2-mediated adherens junctions are required for ependymal cell survival. Peptide blocking of CDH2 HAV domain in vivo, immunostaining, TUNEL assay Journal of neuropathology and experimental neurology Medium 23965744
2013 Forced expression of Cdh2 in mouse iPSCs substantially enhanced neural differentiation efficiency, while shRNA-mediated knockdown of Cdh2 blocked neural differentiation, establishing Cdh2 as a critical regulator of neural differentiation in mouse induced pluripotent stem cells. Forced expression, shRNA knockdown, gene expression microarray, neural differentiation assays Stem cell research Medium 23416351
2014 Inactivation of CDH2 in the dorsal telencephalon disrupted adherens junctions between radial glial cells, dramatically increased progenitor cell proliferation, widely dispersed progenitor cells throughout the developing neocortex, and produced a double cortex-like (subcortical band heterotopia) phenotype, establishing CDH2 as required for normal progenitor proliferation control and cortical lamination. Conditional knockout, histology, immunostaining, BrdU proliferation assay The Journal of neuroscience High 25100583
2018 FOXF1 transcription factor directly binds to Cdh2 and Cdh11 promoters and differentially regulates their transcription; FOXF1 deletion promotes a switch from CDH2 (N-cadherin) to CDH11 (cadherin-11) in lung myofibroblasts, increasing invasion and collagen secretion; re-expression of CDH2 in FOXF1-deficient cells reduced myofibroblast invasion in vitro. ChIP (promoter binding), transgenic mouse FOXF1 conditional knockout, rescue overexpression, invasion assay Cell reports High 29642003
2019 Cdh2 (N-cadherin) is required for Myosin-II-dependent internalisation of the zebrafish neural plate; abrogation of Cdh2 results in defective Myosin-II distribution, mislocalised internalisation events, and defective neural plate morphogenesis, placing CDH2 upstream of actomyosin contractility during neurulation. Quantitative live imaging, mutant analysis, Myosin-II inhibition, zebrafish genetics Scientific reports Medium 30755665
2020 Conditional removal of Cdh2 from postmitotic neuroblasts of the subpallium delayed interneuron precursor migration into the pallium and resulted in a cell-type-specific decrease in adult cortical interneuron numbers, with part of the precursors failing to enter the cortical plate and being eliminated postnatally; this was not due to decreased mitosis, elevated cell death in the subpallium, fate-switching, or altered target selection. Conditional knockout, immunohistochemistry, TUNEL assay, interneuron composition analysis Cerebral cortex Medium 31402374
2022 ALKBH5 (an m6A RNA demethylase) in Sertoli cells regulates m6A levels on Cdh2 mRNA; IGF2BP1/2/3 complexes and YTHDF1 promote Cdh2 mRNA translation; ALKBH5 knockout in mice severely disordered basal ectoplasmic specialization (in which N-cadherin is a main structural protein) and compromised blood-testis barrier integrity. m6A-seq, RNA immunoprecipitation-qPCR, co-immunoprecipitation, polysome fractionation-qPCR, western blot, Alkbh5-KO mouse model, transmission electron microscopy Cellular & molecular biology letters High 36418936
2021 A missense mutation in CDH2 that affects N-cadherin maturation causes familial ADHD; CRISPR/Cas9 knock-in mice harboring the human mutation showed hyperactivity, impaired presynaptic vesicle clustering, attenuated evoked and spontaneous transmitter release, reduced tyrosine hydroxylase expression, and decreased dopamine levels in ventral midbrain and prefrontal cortex. CRISPR/Cas9 knock-in mouse, behavioral testing, electrophysiology (evoked/spontaneous transmitter release), immunostaining, dopamine quantification Nature communications High 34702855
2023 In mouse embryonic stem cells differentiating into presomitic mesoderm (PSM)-like tissue, Cdh2 knockout downregulated FGF signalling and caused premature cessation of Hes7 oscillations; conversely, Cdh2 overexpression upregulated FGF signalling and prolonged Hes7 oscillations. ChIP-seq established Cdh2 as a direct transcriptional target of Hes7. Cdh2 protein showed a posterior-high gradient in PSM despite dynamic mRNA expression, placing CDH2 downstream of Hes7 and upstream of FGF signalling in the segmentation clock. ChIP-seq (anti-Hes7), Cdh2 knockout in Hes7-reporter ESC-derived PSM, live imaging of Hes7 oscillations, Cdh2 overexpression Development (Cambridge, England) High 40951951
2019 A homozygous CDH2 variant (p.Val289Ile) found in a hypopituitarism patient impaired cell aggregation in vitro; stably transfected L1 fibroblast lines expressing wild-type CDH2 formed large aggregates, whereas cells transfected with variant CDH2 or non-transfected cells showed impaired aggregation, demonstrating that this variant disrupts the cell-adhesion function of N-cadherin. Stable transfection of L1 fibroblasts, quantitative cell aggregation assay Endocrine connections Medium 37166408
2019 Endothelin-1 (EDN1) increases CDH2 expression in human mesenchymal stem cells through endothelin receptor A (EDNRA); promoter activity assays identified GATA2 and MZF1 as transcription factors that bind the CDH2 promoter and are required for EDN1-induced CDH2 upregulation; deletion or point mutation of GATA2 or MZF1 binding sequences abolished this promoter activity. CDH2 promoter activity assay, EDNRA blocker (BQ123), site-directed mutagenesis of promoter binding sites, western blot Molecular therapy. Methods & clinical development Medium 31194009
2024 Nuclear translocation of the cleaved intracellular domain of PCDH9 interacts with DNMT1 and increases its activity, leading to increased DNA methylation at the CDH2 promoter and consequent downregulation of CDH2 expression, thereby reducing gastric cancer cell migration and in vivo metastasis. Co-immunoprecipitation (PCDH9 ICD–DNMT1), DNMT1 activity assay, bisulfite sequencing of CDH2 promoter, CDH2 expression rescue, in vivo metastasis model iScience Medium 38357662
2023 In TM4 Sertoli cells, the AP-1 transcription factor Junb directly binds to AP-1 regulatory elements in the proximal Cdh2 promoter region; ChIP-qPCR and luciferase reporter assays with site-directed mutagenesis confirmed that Junb recruits to several AP-1 sites and that knockdown of Junb decreases Cdh2 expression. siRNA knockdown, ChIP-qPCR, luciferase reporter assay with site-directed mutagenesis Biochemical and biophysical research communications Medium 37119763
2022 lncRNA SNHG15 preferentially localizes at cellular protrusions directed by IMP1; SNHG15 forms a complex with nucleolin and co-transports it to cell protrusions, where nucleolin binds CDH2 mRNA, stabilizes it locally, and enhances its translation, thereby promoting breast cancer cell invasion. RNA immunoprecipitation, co-immunoprecipitation, proximity ligation, localization imaging, CDH2 mRNA stability and translation assays International journal of molecular sciences Medium 37958584
2021 ARTEMIN promotes CDH2 expression via p44/42 MAP kinase signalling; siRNA depletion of CDH2 reduced ARTN-enhanced oncogenicity and chemoresistance to 5-FU, and forced CDH2 expression rescued the reduced mesenchymal properties after ARTN depletion, placing CDH2 downstream of ARTN/p44/42 MAPK in colorectal carcinoma. siRNA knockdown, forced expression, MAP kinase inhibition, cell invasion/migration assays, xenograft model Frontiers in oncology Medium 34422665
2022 CRISPR/Cas9-mediated knockout of Cdh2 in 4T1 breast cancer cells confirmed absence of N-cadherin protein and significantly reduced tumor cell migration, establishing a direct role for CDH2 in cancer cell motility. CRISPR/Cas9 gene knockout, western blot confirmation, transwell migration assay Pharmaceutics Medium 35890278
2025 In osteoblast-like MC3T3 cells, N-cadherin (CDH2) binds to PI3K components p85α and p110, restraining PI3K-Akt-β-catenin signalling; Cdh2 ablation enhances Tgf-β1-activated PI3K signalling, increases Tgf-β1 production via enhanced Sp1/Lef-1 binding to the Tgfb1 promoter, upregulates miR-21, and decreases PTEN, creating a pro-tumorigenic feed-forward loop that promotes breast cancer cell growth. Cdh2 ablation, Co-immunoprecipitation (CDH2–p85α/p110), PI3K activity assay, Tgfb1 promoter assay with ChIP (Sp1/Lef-1), miR-21 measurement, PTEN western blot, co-culture and co-injection tumor models, Tgfbr1 genetic ablation epistasis bioRxivpreprint Medium bio_10.1101_2025.10.22.683948
2025 Ndrg1b promotes recycling of N-cadherin (cdh2) to the plasma membrane in zebrafish muscle cells; loss of Ndrg1b disrupts N-cadherin subcellular localization, impairs cell adhesion in vitro, and causes defective skeletal muscle morphogenesis phenotypically similar to cdh2 loss, identifying Ndrg1b as a component of the endocytic trafficking machinery for CDH2. Zebrafish morpholino/genetic knockdown of ndrg1b, N-cadherin localization imaging, cell aggregation assay, rescue experiments bioRxivpreprint Low bio_10.1101_2025.05.08.652902
2025 In the DSG2 interactome of primary neonatal cardiomyocytes, over half of DSG2-associated proteins are shared with the N-cadherin (CDH2) interactome; plakoglobin (JUP) and plakophilin 2 (PKP2) were the most abundant proteins shared between DSG2 and CDH2 interactomes, suggesting CDH2 and DSG2 participate in overlapping adhesion complexes at the intercalated disc. Proximity labeling (BioID), quantitative mass spectrometry, interactome comparison bioRxivpreprint Low bio_10.1101_2025.06.09.658637
2025 In chick embryo dorsal forebrain neuroepithelium, Cdh2 spatiotemporal expression mirrors a tissue stiffness gradient during roof plate invagination; the interplay between Cdh2 and F-actin modulates tissue stiffness by regulating apical adherens junction stability and cortical F-actin distribution along the apico-basal axis, contributing to roof plate morphogenesis. Atomic force microscopy (tissue stiffness mapping), Cdh2 expression analysis, F-actin perturbation, adherens junction immunostaining in chick embryo bioRxivpreprint Low bio_10.1101_2025.11.03.686203
2025 lncRNA MEG3 recruits the histone acetyltransferase EP300 to the CDH2 locus in hippocampal neurons of ASD rats, activating CDH2 transcription; CDH2 upregulation represses neuronal viability and promotes apoptosis in this model, and MEG3 knockdown ameliorated ASD-like learning/memory impairments through reduced CDH2. Microarray, ChIP (MEG3–EP300 recruitment to CDH2 promoter), CDH2 depletion, MEG3 knockdown in rat ASD model Neuroscience letters Medium 35697159

Source papers

Stage 0 corpus · 60 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2015 CDH2 and CDH11 act as regulators of stem cell fate decisions. Stem cell research 134 25771201
2017 Identification of Cadherin 2 (CDH2) Mutations in Arrhythmogenic Right Ventricular Cardiomyopathy. Circulation. Cardiovascular genetics 121 28280076
2018 FOXF1 Inhibits Pulmonary Fibrosis by Preventing CDH2-CDH11 Cadherin Switch in Myofibroblasts. Cell reports 84 29642003
2014 microRNA-194 suppresses osteosarcoma cell proliferation and metastasis in vitro and in vivo by targeting CDH2 and IGF1R. International journal of oncology 66 25096247
2015 Specific deletion of Cdh2 in Sertoli cells leads to altered meiotic progression and subfertility of mice. Biology of reproduction 54 25631347
2014 Proliferative defects and formation of a double cortex in mice lacking Mltt4 and Cdh2 in the dorsal telencephalon. The Journal of neuroscience : the official journal of the Society for Neuroscience 54 25100583
2016 MicroRNA-124 Functions as a Tumor Suppressor by Regulating CDH2 and Epithelial-Mesenchymal Transition in Non-Small Cell Lung Cancer. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 43 27073840
2020 LncRNA JPX overexpressed in oral squamous cell carcinoma drives malignancy via miR-944/CDH2 axis. Oral diseases 40 32881231
2013 Disruption of CDH2/N-cadherin-based adherens junctions leads to apoptosis of ependymal cells and denudation of brain ventricular walls. Journal of neuropathology and experimental neurology 40 23965744
2020 Protective effects of P2X7R antagonist in sepsis-induced acute lung injury in mice via regulation of circ_0001679 and circ_0001212 and downstream Pln, Cdh2, and Nprl3 expression. The journal of gene medicine 39 32783373
2017 Whole exome sequencing with genomic triangulation implicates CDH2-encoded N-cadherin as a novel pathogenic substrate for arrhythmogenic cardiomyopathy. Congenital heart disease 39 28326674
2019 Down-Regulation of Circular RNA_000926 Attenuates Renal Cell Carcinoma Progression through miRNA-411-Dependent CDH2 Inhibition. The American journal of pathology 36 31476285
2022 Flying under the radar: CDH2 (N-cadherin), an important hub molecule in neurodevelopmental and neurodegenerative diseases. Frontiers in neuroscience 35 36213737
2022 ALKBH5 in mouse testicular Sertoli cells regulates Cdh2 mRNA translation to maintain blood-testis barrier integrity. Cellular & molecular biology letters 33 36418936
2018 miR-194 Suppresses Proliferation and Migration and Promotes Apoptosis of Osteosarcoma Cells by Targeting CDH2. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 33 29518783
2013 Rare missense neuronal cadherin gene (CDH2) variants in specific obsessive-compulsive disorder and Tourette disorder phenotypes. European journal of human genetics : EJHG 32 23321619
2021 CDH2 mutation affecting N-cadherin function causes attention-deficit hyperactivity disorder in humans and mice. Nature communications 30 34702855
2020 Ligand-independent EphB1 signaling mediates TGF-β-activated CDH2 and promotes lung cancer cell invasion and migration. Journal of Cancer 22 32368295
2018 MicroRNA-194 regulates cell viability and apoptosis by targeting CDH2 in prostatic cancer. OncoTargets and therapy 20 30147335
2013 Immediate expression of Cdh2 is essential for efficient neural differentiation of mouse induced pluripotent stem cells. Stem cell research 19 23416351
2019 Novel variants in CDH2 are associated with a new syndrome including Peters anomaly. Clinical genetics 18 31650526
2015 Cdh2 stabilizes FGFR1 and contributes to primed-state pluripotency in mouse epiblast stem cells. Scientific reports 18 26420260
2020 CDH2/N-cadherin and early diagnosis of invasion in patients with ductal carcinoma in situ. Breast cancer research and treatment 17 32683564
2022 Biosynthetic Nanobubble-Mediated CRISPR/Cas9 Gene Editing of Cdh2 Inhibits Breast Cancer Metastasis. Pharmaceutics 16 35890278
2018 A novel non-coding RNA within an intron of CDH2 and association of its SNP with non-syndromic cleft lip and palate. Gene 16 29524576
2019 Cdh2 coordinates Myosin-II dependent internalisation of the zebrafish neural plate. Scientific reports 14 30755665
2022 MicroRNA-124 inhibits canine mammary carcinoma cell proliferation, migration and invasion by targeting CDH2. Research in veterinary science 13 35290861
2023 Strontium-modified titanium substrate promotes osteogenic differentiation of MSCs and implant osseointegration via upregulating CDH2. Clinical oral implants research 12 36691814
2024 Nuclear translocation of cleaved PCDH9 impairs gastric cancer metastasis by downregulating CDH2 expression. iScience 11 38357662
2015 Polymorphisms within the neuronal cadherin (CDH2) gene are associated with obsessive-compulsive disorder (OCD) in a South African cohort. Metabolic brain disease 11 26093892
2020 N-cadherin (Cdh2) Maintains Migration and Postmitotic Survival of Cortical Interneuron Precursors in a Cell-Type-Specific Manner. Cerebral cortex (New York, N.Y. : 1991) 10 31402374
2019 Identification of a single-nucleotide polymorphism within CDH2 gene associated with bone morbidity in childhood acute lymphoblastic leukemia survivors. Pharmacogenomics 10 30983502
2023 Targeting N-cadherin (CDH2) and the malignant bone marrow microenvironment in acute leukaemia. Expert reviews in molecular medicine 9 37132370
2022 The role of CDH2 and MCP-1 mRNAs of blood extracellular vesicles in predicting early-stage diabetic nephropathy. PloS one 9 35363774
2023 SNHG15-Mediated Localization of Nucleolin at the Cell Protrusions Regulates CDH2 mRNA Expression and Cell Invasion. International journal of molecular sciences 8 37958584
2014 Balancing selection on CDH2 may be related to the behavioral features of the Belgian Malinois. PloS one 8 25303325
2022 hsa_circ_0000285 facilitates thyroid cancer progression by regulating miR-127-5p/CDH2. Journal of clinical laboratory analysis 7 35447001
2019 Endothelin-1 Augments Therapeutic Potency of Human Mesenchymal Stem Cells via CDH2 and VEGF Signaling. Molecular therapy. Methods & clinical development 7 31194009
2016 Vitamin E and caloric restriction promote hepatic homeostasis through expression of connexin 26, N-cad, E-cad and cholesterol metabolism genes. The Journal of nutritional biochemistry 7 27816814
2025 Extracellular vesicle-LncRNA HOTAIR modulates esophageal cancer chemoresistance and immune microenvironment via miR-375/CDH2 pathway. Journal of cell communication and signaling 6 40235720
2019 CDH2 gene rs11564299 polymorphism is a risk factor for knee osteoarthritis in a Chinese population: a case-control study. Journal of orthopaedic surgery and research 6 31288825
2017 Differentially expressed genes: OCT-4, SOX2, STAT3, CDH1 and CDH2, in cultured mesenchymal stem cells challenged with serum of women with endometriosis. Journal, genetic engineering & biotechnology 6 30647706
2024 The role of lncRNA SNHG14 in gastric cancer: enhancing tumor cell proliferation and migration, and mechanisms of CDH2 expression. Cell cycle (Georgetown, Tex.) 5 38193271
2023 Effect of CDH1 and CDH2 genes polymorphisms in oral squamous cell carcinoma susceptibility in a sample of Iranian population: A case-control study. Health science reports 5 37091359
2022 LncRNA MEG3 activates CDH2 expression by recruitment of EP300 in valproic acid-induced autism spectrum disorder. Neuroscience letters 5 35697159
2021 ARTEMIN Promotes Oncogenicity and Resistance to 5-Fluorouracil in Colorectal Carcinoma by p44/42 MAPK Dependent Expression of CDH2. Frontiers in oncology 5 34422665
2018 Analysis of the association between CDH2 gene polymorphism and osteoarthritis risk. Medecine sciences : M/S 5 30403184
2023 Homozygous CDH2 variant may be associated with hypopituitarism without neurological disorders. Endocrine connections 4 37166408
2022 A Novel nonsense variant in the CDH2 gene associated with ACOGS: A case report. American journal of medical genetics. Part A 4 35708058
2025 Proteome-driven transcriptomic dissection of EMT networks in bladder cancer based on the VIM and CDH2 protein macromolecules influence: From molecular-protein subtyping to therapeutic target prioritization. International journal of biological macromolecules 3 40419050
2024 Differential Impact of Valproic Acid on SLC5A8, SLC12A2, SLC12A5, CDH1, and CDH2 Expression in Adult Glioblastoma Cells. Biomedicines 3 39061990
2023 Regulation of Cdh2 by the AP-1 family transcription factor Junb in TM4 Sertoli cells. Biochemical and biophysical research communications 2 37119763
2023 Case Report: Identification of novel CDH2 mutation (p. P183A het)-induced arrhythmogenic cardiomyopathy in China. Frontiers in cardiovascular medicine 2 38075981
2025 Cdh2, a downstream target of Hes7, regulates somitogenesis by supporting FGF signalling. Development (Cambridge, England) 1 40951951
2025 Comparison of the Effect of the Combination of Sodium Valproate and Sodium Dichloroacetate on the Expression of SLC12A2, SLC12A5, CDH1, CDH2, EZH2, and GFAP in Primary Female Glioblastoma Cells with That of Temozolomide. Pharmaceutics 1 41012498
2024 Standardizing CRISPR-Cas13 knockdown technique to investigate the role of cdh2 gene in pituitary development through growth hormone expression and transcription factors. Frontiers in endocrinology 1 39449741
2026 Correction to "Extracellular vesicle-LncRNA HOTAIR modulates esophageal cancer chemoresistance and immune microenvironment via miR-375/CDH2 pathway". Journal of cell communication and signaling 0 41737730
2026 Phenotypic discordance in monozygotic twins with a CDH2 variant. European journal of medical genetics 0 41997214
2025 Proteome Profiling Identifies CDH2 as a Potential Screening Marker for NAFLD and Liver Fibrosis in the Snoring Population. Nature and science of sleep 0 41113904
2025 Epigenetic modifications of the PHOX2A and CDH2 genes expression- new insights into the pathogenesis of multiple myeloma. BMC cancer 0 41146049

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