Affinage

DDX17

Probable ATP-dependent RNA helicase DDX17 · UniProt Q92841

Length
729 aa
Mass
80.3 kDa
Annotated
2026-06-09
100 papers in source corpus 37 papers cited in narrative 37 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 9/9 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

DDX17 (p72) is a nuclear DEAD-box RNA helicase whose ATP-dependent RNA unwinding, annealing, and structural rearrangement activities underpin a broad range of RNA-processing and gene-regulatory functions (PMID:11353078). As an enzyme it binds RNA in an ATP-dependent manner, possesses both unwinding and annealing activities, and can catalyze branch-migration-type rearrangement of stable RNA secondary structures; an alternative non-AUG translation start produces a larger p82 isoform with comparable helicase activity (PMID:11353078, PMID:11675387). In RNA metabolism it promotes alternative exon inclusion (e.g., AC-rich CD44 exons) in a manner requiring both ATP-binding and its C-terminal region, cooperates with hnRNP H/F and the splicing factors SRSF1 and U2AF to define cell-type-specific splicing programs, and contributes to ribosome biogenesis through structural rearrangement during 32S pre-rRNA processing (PMID:12138182, PMID:24910439, PMID:30131116, PMID:17485482). DDX17 also acts in microRNA biogenesis by sequence-specifically recognizing and remodeling pri-miRNA stem-loops to enhance Drosha cleavage, an activity tuned by an autoregulatory intramolecular interaction between its N-terminal tail and the DEAD domain (PMID:31851931, PMID:25126784). Beyond RNA processing, DDX17 functions as a transcriptional co-regulator, partnering with diverse factors including MyoD, β-catenin, ERα, p53/MDM2, REST, SOX2, Klf4, YB1, BCL6, NFAT5, and the coactivators p300/CBP/P/CAF and HDAC1 to activate or repress target genes and to drive differentiation, proliferation, and stem-like programs (PMID:17011493, PMID:17699760, PMID:19718048, PMID:17226766, PMID:29931089). Its activity and stability are controlled by SUMOylation, p300-mediated acetylation, and HectH9-mediated K63-linked polyubiquitination under hypoxia, the latter switching DDX17 from a Drosha-associated miRNA-processing role to a p300-YAP-associated chromatin-activating role (PMID:19995069, PMID:20663877, PMID:30877109). In the nucleus DDX17 resolves R-loops to promote MUS81-dependent restart of stalled replication forks and participates in the DNA double-strand-break response (PMID:36453994, PMID:36200807). Through helicase-dependent recognition of structured viral and retrotransposon RNAs it acts in antiviral defense—restricting bunyaviral (RVFV) and hepatitis B virus replication and sensing endogenous SINE RNAs to license a non-canonical NLRC4 inflammasome—while its NLS/NES-dependent nucleocytoplasmic shuttling couples these cytoplasmic roles to nuclear transcription and splicing (PMID:25126784, PMID:34287051, PMID:34860583, PMID:28259822). Cardiomyocyte-specific Ddx17 loss in mice causes heart failure via derepression of the mitochondrial fission gene DRP1 (PMID:38782919).

Mechanistic history

Synthesis pass · year-by-year structured walk · 20 steps
  1. 1996 Medium

    Establishing DDX17 as a bona fide nuclear DEAD-box protein with RNA-stimulated ATPase activity placed it among catalytically active RNA helicases and predicted a nuclear RNA-processing function.

    Evidence Recombinant ATPase assay and immunocytochemistry co-localizing with p68 in HeLa nuclei

    PMID:8871553

    Open questions at the time
    • No RNA substrate or unwinding activity demonstrated
    • No functional mutagenesis linking ATPase activity to a cellular role
  2. 2001 High

    Reconstituted biochemistry showed DDX17 is not merely an ATPase but a true helicase with both unwinding and annealing activities capable of RNA structural rearrangement, defining its core enzymatic repertoire; alternative non-AUG translation additionally produces an active p82 isoform.

    Evidence In vitro RNA unwinding/annealing/branch-migration assays with recombinant protein, plus 5'-UTR mapping and in vitro translation

    PMID:11353078 PMID:11675387

    Open questions at the time
    • Cellular substrates of unwinding vs. annealing not identified
    • Distinct functions of p72 vs p82 isoforms unresolved
  3. 2002 High

    Linking DDX17's ATPase/helicase activity to CD44 alternative exon inclusion provided the first specific RNA-processing function and distinguished it from the paralog p68, showing isoform-specific roles.

    Evidence Minigene transfection, ATP-binding and C-terminal deletion mutants, in vitro splicing extracts, pre-mRNA Co-IP

    PMID:12138182

    Open questions at the time
    • Direct binding to AC-rich enhancer not structurally defined
    • Generality across other exons untested at this stage
  4. 2003 Medium

    Demonstrating that DDX17 and p68 heterodimerize and assemble into larger complexes established the physical basis for their frequently shared, sometimes redundant functions.

    Evidence Yeast two-hybrid, reciprocal Co-IP, gel filtration sizing of complexes

    PMID:12595555

    Open questions at the time
    • Stoichiometry and other subunits of the large complexes unknown
    • Functional consequence of heterodimerization not directly tested
  5. 2004 Medium

    Identifying HDAC1 association and promoter-targeted repression revealed that DDX17 functions in transcriptional regulation, not only RNA processing.

    Evidence Co-IP and reporter repression assays at constitutive promoters

    PMID:15298701

    Open questions at the time
    • Endogenous target genes not defined
    • Mechanism coupling helicase activity to repression unclear
  6. 2006 High

    Defining DDX17/p68 as MyoD coactivators required for recruiting the basal machinery and the Brg-1 chromatin remodeler tied DDX17 to chromatin remodeling and developmental differentiation programs.

    Evidence Reciprocal Co-IP, RNAi loss-of-function, ChIP, myogenic differentiation assays; SRA ncRNA co-IP with MyoD

    PMID:17011493

    Open questions at the time
    • Role of SRA RNA in DDX17 function not mechanistically resolved
    • Whether helicase activity is needed for coactivation untested here
  7. 2007 Medium

    Discovery of DDX17 in β-catenin and p53/MDM2-p300/CBP/P/CAF transcriptional complexes broadened its co-regulator role into oncogenic and tumor-suppressor pathways, with N-terminal mapping to coactivator binding.

    Evidence Co-IP, in vitro binding, N-terminal domain mapping, siRNA knockdown, reporter and xenograft assays

    PMID:17226766 PMID:17699760

    Open questions at the time
    • Direct vs indirect contacts within multiprotein complexes unresolved
    • Contribution of helicase catalysis to transcriptional output unclear
  8. 2007 Medium

    Co-silencing experiments revealed a non-redundant requirement for DDX17/p68 RNA-rearrangement activity in 32S pre-rRNA processing, assigning a role in ribosome biogenesis.

    Evidence siRNA knockdown, rearrangement vs unwinding mutant analysis, nucleolar morphology and pre-rRNA processing assays

    PMID:17485482

    Open questions at the time
    • Direct pre-rRNA substrate engagement not shown
    • Position within pre-60S assembly pathway not mapped
  9. 2009 Medium

    Isoform-specific knockdown established that DDX17, but not p68, is uniquely required for ERα-dependent transcription and estrogen-driven breast cancer cell proliferation.

    Evidence siRNA knockdown, endogenous ERα target gene RT-PCR, proliferation assays in MCF-7/ZR75-1

    PMID:19718048

    Open questions at the time
    • Molecular basis of isoform specificity unexplained
    • Direct DDX17-ERα contact not mapped
  10. 2010 High

    Defining SUMOylation and p300 acetylation as stability- and activity-controlling modifications established a PTM layer governing DDX17's transcriptional coactivation and its HDAC interactions, with SUMO competing against ubiquitin-mediated degradation.

    Evidence Site-directed PTM mutagenesis, protein stability assays, Co-IP, transcriptional reporters, cell-cycle/apoptosis analysis

    PMID:19995069 PMID:20663877

    Open questions at the time
    • Enzymes catalyzing DDX17 SUMOylation not identified
    • Crosstalk between SUMO, acetylation, and ubiquitin not integrated
  11. 2012 Medium

    Showing DDX5/DDX17 both transcriptionally activate NFAT5 and promote an NMD-coupled splicing event revealed a dual transcription-plus-splicing regulatory logic controlling target protein levels.

    Evidence Co-IP, reporter assays, siRNA knockdown, alternative splicing and migration assays

    PMID:22266867

    Open questions at the time
    • Direct splicing substrate recognition not defined
    • Balance between activation and NMD-mediated reduction in vivo unclear
  12. 2013 Medium

    Identifying that p68/Ddx5 drives NMD of DDX17 mRNA via Upf3, and that DDX17 supports HIV-1 particle production, defined an autoregulatory expression loop and an early viral RNA-metabolism role.

    Evidence Co-IP, NMD reporter and 3'-UTR analysis, ATPase mutants; HIV-1 DQAD helicase-dead packaging and frameshift assays

    PMID:23769241 PMID:23788676

    Open questions at the time
    • Physiological setting of the Ddx5-Ddx17 NMD loop untested
    • Direct viral RNA target of DDX17 in HIV-1 not mapped here
  13. 2014 High

    Transcriptome-wide analyses showed DDX17 cooperates with hnRNP H/F to define epithelial/myoblast splicing subprograms and that its own downregulation during differentiation is driven by miRNAs whose biogenesis it controls—revealing a feedback circuit linking splicing, miRNA processing, and differentiation; the same dual stem-loop recognition supports both pri-miRNA processing and direct antiviral RNA binding.

    Evidence siRNA, RNA-seq, CLIP-seq, miRNA profiling, splicing assays; CLIP-seq and viral replication assays in fly and human cells

    PMID:24910439 PMID:25126784

    Open questions at the time
    • Sequence determinants of stem-loop selectivity not yet structurally defined
    • Coordination between nuclear and cytoplasmic RNA-binding pools unclear
  14. 2015 Medium

    Identifying a SOX2-DDX17 interaction restricted to stem-like breast cancer cells extended DDX17's co-regulator role to cancer stemness programs.

    Evidence LC-MS, Co-IP, siRNA, ChIP-PCR, reporter and mammosphere assays

    PMID:26569340

    Open questions at the time
    • Why the interaction is context-restricted not explained
    • Direct vs bridged DDX17-SOX2 contact unresolved
  15. 2017 Medium

    Mapping functional NLS/NES sequences and an exportin/importin-dependent shuttling pathway explained how DDX17 couples nuclear functions to cytoplasmic β-catenin activation and drug resistance.

    Evidence Co-IP, NLS/NES identification, nuclear/cytoplasmic fractionation, β-catenin reporter and gefitinib-resistance assays

    PMID:28259822

    Open questions at the time
    • Signals triggering shuttling not defined
    • Direct cytoplasmic action on E-cadherin/β-catenin complex not biochemically reconstituted
  16. 2018 High

    Defining DDX17-specific control of HIV-1 A4/A5 splice-acceptor usage via SRSF1 and U2AF, and dissecting REST-dependent neuronal gene repression coupled to proneural miRNA processing, demonstrated context-specific splicing/transcription mechanisms relying on specific RNA-binding motifs rather than canonical helicase motifs.

    Evidence siRNA, splicing assays, motif-deletion mutagenesis, Co-IP with splicing factors; ChIP and miRNA processing assays for REST

    PMID:29931089 PMID:30131116

    Open questions at the time
    • Structural basis of motif-dependent splicing recognition undefined
    • Generality of REST-DDX17 control across neuronal genes incomplete
  17. 2019 High

    Crystal structures plus hypoxia-driven K63-ubiquitination by HectH9 explained, at atomic and signaling levels, how DDX17 sequence-specifically remodels pri-miRNA 3' regions and how a PTM switch toggles it between Drosha-associated miRNA processing and p300-YAP-associated chromatin activation of stemness genes.

    Evidence X-ray crystallography with RNA-binding/ATPase/processing assays; K63-linkage ubiquitination, complex pulldowns, H3K56ac ChIP, tumor-initiation assays; plus Klf4 interaction studies

    PMID:30877109 PMID:31653828 PMID:31851931

    Open questions at the time
    • Full-length DDX17 structure with bound pri-miRNA not resolved
    • Deubiquitinase reversing the HectH9 switch unknown
  18. 2021 High

    Biophysical and functional studies established DDX17 as a direct sensor of structured RNAs in innate immunity and viral restriction—quantifying RVFV RNA binding, blocking HBV pgRNA encapsidation by competing with viral polymerase, and licensing a non-canonical NLRC4 inflammasome in response to SINE RNAs—while also showing it rescues mutant-FUS neurodegeneration via stress-granule recruitment and DDR support.

    Evidence MST/SAXS and in vitro unwinding (RVFV); RIP/EMSA, encapsidation and helicase-mutant assays (HBV); Co-IP, caspase-1/IL-18 assays and disease models (NLRC4); Co-IP and in vivo rescue (FUS)

    PMID:33374561 PMID:34061233 PMID:34287051 PMID:34860583

    Open questions at the time
    • How DDX17 discriminates self from non-self structured RNAs is unresolved
    • Mechanism of NLRC4 licensing downstream of RNA sensing not fully defined
  19. 2022 High

    Demonstrating that DDX17 unwinds R-loops to enable MUS81-dependent fork restart and is recruited in the DSB ubiquitin cascade, while also engaging YB1/EGFR transcription, PXN-AS1 splicing-driven MYC activation, and THOC5/CDK12 elongation complexes, established central roles in genome stability and oncogenic gene expression.

    Evidence In vitro R-loop unwinding, DRIP-seq, DNA fiber and γH2AX assays, helicase mutants; Co-IP, ChIP-seq, splicing assays, and KO/transgenic mouse models

    PMID:34626132 PMID:36200807 PMID:36385375 PMID:36417870 PMID:36453994 PMID:36590164

    Open questions at the time
    • How DDX17 both promotes and resolves R-loops at different loci is mechanistically unreconciled
    • Direct DNA/RNA substrate selection at DSB sites not defined
  20. 2024 High

    Cardiomyocyte-specific genetics linked DDX17 to organ physiology, showing that DDX17-BCL6 repression of DRP1 restrains mitochondrial fission and that DDX17 loss causes heart failure.

    Evidence Co-IP, cardiomyocyte-specific KO/transgenic mice, mitochondrial morphology and autophagic flux assays

    PMID:38782919

    Open questions at the time
    • Whether helicase activity is required for BCL6-mediated DRP1 repression untested
    • Upstream signals reducing DDX17 in heart failure unknown

Open questions

Synthesis pass · forward-looking unresolved questions
  • It remains unresolved how DDX17's single enzymatic core is partitioned among its many functions—how RNA-binding specificity, PTMs, and shuttling jointly determine whether it acts as a splicing factor, miRNA-processing enzyme, R-loop helicase, RNA sensor, or transcriptional co-regulator at a given locus and time.
  • No integrated model linking PTM state to functional output
  • Substrate-selection rules distinguishing antiviral, processing, and genome-stability roles undefined
  • Structural basis for partner discrimination among transcription factors unknown

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0003723 RNA binding 4 GO:0140098 catalytic activity, acting on RNA 4 GO:0140110 transcription regulator activity 4 GO:0140657 ATP-dependent activity 3 GO:0140299 molecular sensor activity 2
Localization
GO:0005634 nucleus 2 GO:0005829 cytosol 2 GO:0005730 nucleolus 1
Pathway
R-HSA-8953854 Metabolism of RNA 4 R-HSA-1643685 Disease 3 R-HSA-168256 Immune System 3 R-HSA-74160 Gene expression (Transcription) 3 R-HSA-73894 DNA Repair 2
Partners
BCL6CTNNB1DDX5ESR1HDAC1P300SRSF1U2AF2
Complex memberships
Drosha-DGCR8 microprocessorNLRC4-NLRP3-ASC inflammasomeTHOC5-DDX5-DDX17-CDK12-THOC6 complex

Evidence

Reading pass · 37 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1996 DDX17 (p72) is a nuclear DEAD-box protein that exhibits ATPase activity in the presence of RNA; immunocytochemistry showed it co-localizes with p68 in the nucleus of HeLa cells, consistent with a nuclear function. Recombinant protein purification, ATPase assay, immunocytochemistry Nucleic acids research Medium 8871553
2001 DDX17 (p72) possesses both RNA helicase (unwinding) and RNA annealing activities, and can catalyze ATP-dependent rearrangement of stable RNA secondary structures via branch migration intermediates, analogous to certain DNA helicases. In vitro biochemical assays with recombinant p72 protein; RNA unwinding and annealing assays Nucleic acids research High 11353078
2001 The p72 mRNA contains a 5'-UTR with an upstream non-AUG codon that drives alternative translation to produce an 82 kDa isoform (p82) with RNA helicase activity nearly identical to p72; p82 is a naturally expressed protein in HeLa cells. 5' UTR mapping, in vitro translation, immunological characterization, purification and helicase assay The Journal of biological chemistry High 11675387
2002 DDX17 (p72) specifically promotes inclusion of CD44 alternative exons containing AC-rich exon enhancer elements; this requires both the helicase ATP-binding activity and the C-terminal region of p72. The related protein p68 does not share this splicing activity. p72 associates with pre-mRNA complexes in vitro. Transient transfection of minigenes, ATPase-site mutants, deletion mutants, in vitro splicing extracts, co-immunoprecipitation with pre-mRNA Molecular and cellular biology High 12138182
2003 DDX17 (p72) and p68 interact with each other and self-associate; they preferentially exist as heterodimers in cells. p68 also interacts with NFAR-2. Gel filtration indicates p68/p72 exist in complexes of ~150–400 kDa, with a subset of p68 in very large complexes (>2 MDa). Yeast two-hybrid, co-immunoprecipitation, gel filtration chromatography Nucleic acids research Medium 12595555
2004 DDX17 (p72) and p68 associate with histone deacetylase 1 (HDAC1) and repress transcription in a promoter-specific manner when targeted to constitutive promoters. Co-immunoprecipitation, reporter gene transcription repression assays BMC molecular biology Medium 15298701
2006 DDX17 (p72) and p68 are MyoD-associated proteins that co-activate MyoD-dependent muscle gene expression; knockdown of p68/p72 impairs recruitment of TBP, RNA polymerase II, and Brg-1 (SWI/SNF ATPase subunit) to muscle gene promoters, and blocks chromatin remodeling and skeletal muscle differentiation. The noncoding RNA SRA also co-immunoprecipitates with MyoD. Co-immunoprecipitation, RNA interference, chromatin immunoprecipitation, differentiation assays Developmental cell High 17011493
2007 DDX17 (p72) and p68 form complexes with beta-catenin and promote beta-catenin-dependent transcription of target genes (c-Myc, cyclin D1, c-jun, fra-1); simultaneous knockdown reduces beta-catenin target gene expression, enhances p21 expression, inhibits proliferation, and reduces tumor formation in vivo. Co-immunoprecipitation, siRNA knockdown, reporter gene assays, xenograft tumor assays Cancer research Medium 17699760
2007 DDX17 (p72) RNA helicase forms complexes with the coactivators p300/CBP via its N-terminal 63 amino acids, and also binds P/CAF; these three proteins synergize to activate the Mdm2 promoter. Knockdown of p72 reduces Mdm2 transcription in a p53-dependent and -independent manner. Co-immunoprecipitation, in vitro binding assays, reporter gene assays, siRNA knockdown Journal of cellular biochemistry Medium 17226766
2007 p68 negatively controls p72/p82 gene expression (but not vice versa). Co-silencing of both p68 and p72/p82 causes perturbation of nucleolar structure and cell death; the nucleolytic cleavage of 32S pre-rRNA is reduced, consistent with a role in structural rearrangement of the pre-60S ribosomal subunit. The redundant function maps to RNA rearrangement (not unwinding) activity. siRNA knockdown, mutant studies distinguishing rearrangement vs. unwinding activity, nucleolar morphology, pre-rRNA processing assays Nucleic acids research Medium 17485482
2008 DDX17 (p72), but not the highly similar p68, is identified as a ZAP (zinc-finger antiviral protein)-interacting protein. ZAP binds via its N-terminal domain; both N- and C-terminal domains of p72 bind ZAP. p72 RNA helicase activity is required for promoting ZAP-mediated viral RNA degradation. Overexpression of the p72 C-terminal domain reduces ZAP activity; full-length p72 enhances it. Knockdown of p72 reduces ZAP activity but does not affect tristetraprolin-mediated RNA degradation. Co-immunoprecipitation, domain mapping, RNAi knockdown, viral RNA degradation assays, helicase-dead mutant Proceedings of the National Academy of Sciences of the United States of America High 18334637
2009 siRNA-mediated knockdown of DDX17 (p72), but not p68, significantly inhibits oestrogen-dependent transcription of endogenous ERα-responsive genes and oestrogen-dependent proliferation of MCF-7 and ZR75-1 breast cancer cells, demonstrating a non-redundant role for p72 in ERα co-activation. siRNA knockdown, RT-PCR of endogenous ERα target genes, cell proliferation assays Oncogene Medium 19718048
2010 DDX17 (p72) and p68 are sumoylated at a single, homologous consensus SUMO site; sumoylation significantly increases protein stability of both proteins. Preventing sumoylation of p72 increases its ability to transactivate estrogen receptor and p53, while sumoylation promotes interaction of p68/p72 with HDAC1 (but not HDAC2/3, p300, or estrogen receptor). p68 but not p72 is polyubiquitylated, and mutation of the sumoylation site increases p68 polyubiquitylation, suggesting SUMO competes with ubiquitin-mediated proteasomal degradation for p68. Sumoylation site mutagenesis, protein stability assays, co-immunoprecipitation, transcriptional reporter assays Biochemistry High 19995069
2010 DDX17 (p72) and p68 are substrates for acetylation by the acetyltransferase p300 in vitro and in vivo. Mutation of acetylation sites affects binding to HDACs (but not to p300 or estrogen receptor). Acetylation increases protein stability and coactivation of estrogen receptor. Acetylation of p72 (but not p68) also enhances p53-dependent MDM2 promoter activation. Blocking p72 acetylation causes cell cycle arrest and apoptosis. In vitro acetylation assay, acetylation-site mutagenesis, co-immunoprecipitation, reporter gene assays, cell cycle/apoptosis analysis The Journal of biological chemistry High 20663877
2012 DDX5 and DDX17 act as transcriptional coactivators of NFAT5 and are required for activating NFAT5 target genes involved in tumor cell migration. In parallel, DDX5/DDX17 promote inclusion of NFAT5 exon 5 (which contains a premature stop codon), coupling transcriptional activation to NMD-mediated reduction of NFAT5 protein levels — a dual regulatory role. Co-immunoprecipitation, reporter gene assays, siRNA knockdown, alternative splicing assays, migration assays Oncogene Medium 22266867
2013 p68 (Ddx5) binds Upf3 protein of the NMD machinery; this interaction interferes with EJC binding. Ddx5 activates NMD of Ddx17/p72 mRNA (and Smg5 mRNA) in an ATP-binding-dependent manner requiring the 3'-UTR of target mRNAs, thereby establishing a regulatory loop controlling p72 expression levels. Co-immunoprecipitation, NMD reporter assays, ATPase mutant studies, 3'-UTR deletion analysis Nucleic acids research Medium 23788676
2013 DDX17 promotes production of infectious HIV-1 particles; its helicase activity is required. A DQAD helicase-dead mutant reduces packaging of viral genomic RNA and diminishes HIV-1 Gag-Pol frameshift, demonstrating that DDX17 modulates HIV-1 RNA metabolism to support infectious particle production. Overexpression of helicase-dead mutant (DQAD), viral RNA packaging assay, frameshifting assay Virology Medium 23769241
2014 DDX17 cooperates with hnRNP H/F splicing factors to define epithelial- and myoblast-specific splicing subprograms. Downregulation of DDX5/DDX17 protein during myogenesis and EMT is mediated by differentiation-induced miRNAs whose biogenesis itself depends on DDX5/DDX17. DDX5/DDX17 also function as coregulators of master transcriptional regulators of differentiation. siRNA knockdown, RNA-seq, CLIP-seq, miRNA profiling, alternative splicing assays Cell reports High 24910439
2014 DDX17 binds the stem loops of host pri-miRNA to facilitate their processing by Drosha (nuclear function), and also directly binds a specific stem loop in bunyaviral (RVFV) RNA to restrict infection (cytoplasmic function). Loss of DDX17 (but not the related DDX5) specifically increases RVFV replication. This dual stem-loop recognition underlies both roles. RNAi screening, CLIP-seq, genetic depletion in Drosophila and human cells, viral replication assays Cell High 25126784
2015 DDX17 (p72) physically interacts with Sox2 via co-immunoprecipitation, and this interaction is preferentially restricted to Sox2-reporter-responsive (stem-like) breast cancer cells where DDX17 is nuclear. DDX17 knockdown reduces Sox2-SRR2 promoter binding and Sox2-dependent target gene expression (MUC15, CCND1, CD133), as well as colony and mammosphere formation in stem-like cells. LC-MS (initial identification), co-immunoprecipitation, siRNA knockdown, ChIP-PCR, reporter assays, colony/mammosphere assays Cellular signalling Medium 26569340
2017 DDX17 promotes gefitinib resistance in NSCLC cells by dissociating the E-cadherin/β-catenin complex, causing β-catenin nuclear translocation and transcription of β-catenin target genes. DDX17 undergoes nucleocytoplasmic shuttling via nuclear localization signals (NLS) and nuclear export signals (NES) through an exportin/importin-dependent pathway; disrupting this shuttling impairs β-catenin activation and acquired resistance. Co-immunoprecipitation, NLS/NES sequence identification, nuclear/cytoplasmic fractionation, β-catenin reporter assays, drug resistance assays Cancer letters Medium 28259822
2018 DDX17 controls REST-dependent transcriptional repression of neuronal genes by associating with REST and promoting its binding to a subset of REST-target gene promoters. During neuronal differentiation, DDX17 downregulation contributes to REST complex release and neuronal gene activation. DDX17 and DDX5 also regulate processing of proneural miRNAs (including miR-26a/b) that target the REST complex; an intronic regulatory region negatively impacts miR-26a2 processing and splicing in a DDX17-dependent manner. Co-immunoprecipitation, ChIP, siRNA knockdown, miRNA processing assays, luciferase reporter assays Nucleic acids research Medium 29931089
2018 DDX17 controls HIV-1 splicing specifically at the A4/A5 splice acceptor cluster (but not A1), independently of DDX5. In the absence of DDX17, viral envelope protein production and other accessory proteins are severely reduced. DDX17 interacts with splicing factors SRSF1/SF2 and U2AF65/35. Specific RNA-binding motifs (not the Walker A, Walker B/DEAD, Q motif, or glycine doublet) are essential for this splicing function. siRNA knockdown, splicing assays, motif-deletion mutagenesis, co-immunoprecipitation with splicing factors Journal of molecular biology High 30131116
2019 Under hypoxia, the E3 ubiquitin ligase HectH9 mediates K63-linked polyubiquitination of DDX17. Polyubiquitinated DDX17 dissociates from the Drosha-DGCR8 complex (reducing biogenesis of anti-stemness miRNAs) and associates with p300-YAP, leading to H3K56 acetylation at stemness-related gene promoters and their transcriptional activation, promoting cancer stem-like properties. Ubiquitination assays (K63-linkage specific), Co-IP, Drosha complex pulldown, ChIP (H3K56ac), miRNA profiling, tumor-initiating capacity assays Cancer research High 30877109
2019 Crystal structures of the DDX17 core catalytic domain revealed sequence-specific RNA recognition; the catalytic core binds and remodels a specific region of primary miRNA 3' to the mature sequence, enhancing Drosha processing. An intramolecular interaction between the DDX17 N-terminal tail and the DEAD domain acts as an autoregulatory mechanism controlling ATPase activity. X-ray crystallography, biochemical RNA-binding and ATPase assays, pri-miRNA processing assays Cell reports High 31851931
2019 DDX17 physically interacts with Klf4 (demonstrated by co-IP and GST pull-down); DDX17 inhibits Klf4 transcriptional activity at target gene promoters (E-cadherin, MMP2) and prevents Klf4 from binding the MMP2 promoter. The interaction requires the zinc-finger domain of Klf4. Co-immunoprecipitation, GST pull-down, luciferase reporter assay, ChIP (Klf4 promoter binding), Klf4 domain deletion Cell death & disease Medium 31653828
2020 DDX17 directly binds RVFV non-coding RNAs (intergenic region, IGR, and 5' NCR) with Kd values of 5.77 µM and 9.85 µM respectively (measured by microscale thermophoresis), and the helicase domain (DDX17135-555) can unwind both RNAs in vitro. Microscale thermophoresis, SAXS, analytical ultracentrifugation, helicase unwinding assay International journal of molecular sciences High 33374561
2021 DDX17 is identified as the sensor of endogenous SINE RNAs (retrotransposon RNAs) that activates the NLRC4 inflammasome independently of NAIPs. DDX17 licenses assembly of an inflammasome comprising NLRC4, NLRP3, and ASC, driving caspase-1 activation and cytokine (IL-18) release. Inhibiting DDX17-mediated NLRC4 activation reduced IL-18 in SLE patient PBMCs and prevented retinal degeneration in an AMD animal model. siRNA knockdown, co-immunoprecipitation, caspase-1 activation assay, cytokine release assay, in vivo retinal degeneration model Science immunology High 34860583
2021 DDX17 inhibits HBV replication primarily by blocking cytoplasmic encapsidation of pregenomic RNA (pgRNA). DDX17 competes with HBV polymerase to bind the 5' epsilon stem-loop of pgRNA. Immunofluorescence showed DDX17 translocates from nucleus to cytoplasm in the presence of HBV RNA. This antiviral function is helicase-activity dependent. RNA immunoprecipitation, EMSA (electrophoretic mobility shift assay), immunofluorescence, encapsidation assay, helicase-dead mutant Journal of virology High 34287051
2021 Mutant FUS recruits nuclear DDX17 into cytoplasmic stress granules and physically interacts with DDX17 through the RGG1 domain of FUS. Ectopic expression of DDX17 reduces cytoplasmic mislocalization of mutant FUS and suppresses FUS-mediated neurodegeneration in vivo. DDX17 functions as a regulator of the DNA damage response and its upregulation repairs defective DDR caused by mutant FUS. Co-immunoprecipitation (RGG1 domain), immunofluorescence (stress granule localization), overexpression rescue in vivo (Drosophila), DNA damage assays Acta neuropathologica Medium 34061233
2021 DDX17 regulates alternative splicing of PXN-AS1 by inducing intron 3 retention, producing transcript PXN-AS1-IR3 that recruits TEX10 and p300 to the MYC enhancer to activate MYC transcription and downstream metastasis-associated genes. DDX17 knockout in a mouse model inhibits HCC metastasis. RNA-seq, splicing assays, Co-IP (TEX10/p300 complex), ChIP (MYC enhancer), DDX17 knockout mouse model Hepatology (Baltimore, Md.) Medium 34626132
2022 DDX17 helicase unwinds R-loops in vitro and promotes MUS81-dependent restart of R-loop-stalled replication forks in human cells. Loss of DDX17 causes R-loop accumulation, anaphase bridges, and micronuclei. DDX17 associates with R-loops and facilitates their formation (specifically at loci with low pre-existing hybrid levels) to allow propagation of DSB ubiquitin cascade responses. In vitro R-loop unwinding assay, S9.6 immunofluorescence (R-loop detection), genome-wide R-loop mapping (DRIP-seq), DNA fiber assay (fork restart), helicase mutant Nucleic acids research High 36453994
2022 DDX17 is required for efficient DSB repair; it is recruited early in the DSB ubiquitin cascade and promotes formation of DNA:RNA hybrids (R-loops) at DSB sites specifically at loci with low pre-existing hybrids. Loss of DDX17 impairs cell survival and DNA repair in response to DSB-inducing agents. Proteomic meta-analysis, siRNA knockdown, γH2AX foci assay, R-loop mapping (DRIP), DSB repair factor recruitment assays Nucleic acids research Medium 36200807
2022 DDX17 acts as a transcriptional regulator that interacts with Y-box binding protein 1 (YB1) in the nucleus, driving YB1 binding to the EGFR promoter to activate EGFR transcription and downstream MEK/pERK signaling. MTDH stabilizes DDX17 by inhibiting its ubiquitination. Co-immunoprecipitation, ChIP-seq, promoter reporter assay, ubiquitination assay, in vitro and in vivo functional studies Oncogene Medium 36385375
2022 THOC5 interacts with DDX17 (and DDX5) specifically in slow RNA polymerase II cells; this chromatin-associated complex also includes CDK12 and THOC6, and is involved in regulating R-loop structures and transcription elongation rate. Co-immunoprecipitation, THOC5 depletion, transcription elongation measurement, R-loop analysis iScience Medium 36590164
2022 JICD1 (JAG1 intracellular domain) forms a transcriptional complex with DDX17, SMAD3, and TGIF2 to drive SOX2 expression and cancer stem-like transformation of astrocytes. ChIP-seq confirmed complex binding at the SOX2 locus. Proteomics, co-immunoprecipitation, ChIP-seq, reporter assays, functional transformation assays Cell reports Medium 36417870
2024 DDX17 binds the transcriptional repressor BCL6 and inhibits expression of DRP1 (a mitochondrial fission protein). When DDX17 is reduced (as in heart failure), BCL6 repression is attenuated, DRP1 expression increases, mitochondrial fission is enhanced, and autophagy flux is blocked, leading to cardiomyocyte apoptosis and progressive cardiac dysfunction. Cardiomyocyte-specific Ddx17 knockout mice develop heart failure, while DDX17 restoration protects cardiac function. Co-immunoprecipitation (DDX17-BCL6), cardiomyocyte-specific KO and transgenic mice, mitochondrial morphology assays, autophagic flux assays, DRP1 expression analysis Signal transduction and targeted therapy High 38782919

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2003 Genotyping field strains of African swine fever virus by partial p72 gene characterisation. Archives of virology 398 12664294
2006 The RNA helicases p68/p72 and the noncoding RNA SRA are coregulators of MyoD and skeletal muscle differentiation. Developmental cell 249 17011493
1991 Interleukin 2 induces tyrosine phosphorylation and activation of p72-74 Raf-1 kinase in a T-cell line. Proceedings of the National Academy of Sciences of the United States of America 196 1996324
2008 Enhanced discrimination of African swine fever virus isolates through nucleotide sequencing of the p54, p72, and pB602L (CVR) genes. Virus genes 177 19009341
1993 Cross-linking of Fc gamma receptor I (Fc gamma RI) and receptor II (Fc gamma RII) on monocytic cells activates a signal transduction pathway common to both Fc receptors that involves the stimulation of p72 Syk protein tyrosine kinase. The Journal of biological chemistry 175 8226994
2014 RNA helicases DDX5 and DDX17 dynamically orchestrate transcription, miRNA, and splicing programs in cell differentiation. Cell reports 168 24910439
2007 Involvement of RNA helicases p68 and p72 in colon cancer. Cancer research 161 17699760
2007 Redundant role of DEAD box proteins p68 (Ddx5) and p72/p82 (Ddx17) in ribosome biogenesis and cell proliferation. Nucleic acids research 131 17485482
2013 The DEAD box proteins DDX5 (p68) and DDX17 (p72): multi-tasking transcriptional regulators. Biochimica et biophysica acta 127 23523990
2004 The p68 and p72 DEAD box RNA helicases interact with HDAC1 and repress transcription in a promoter-specific manner. BMC molecular biology 124 15298701
2009 The DEAD-box protein p72 regulates ERalpha-/oestrogen-dependent transcription and cell growth, and is associated with improved survival in ERalpha-positive breast cancer. Oncogene 107 19718048
2002 Regulation of alternative splicing by the ATP-dependent DEAD-box RNA helicase p72. Molecular and cellular biology 107 12138182
2014 Stem-loop recognition by DDX17 facilitates miRNA processing and antiviral defense. Cell 104 25126784
2011 RNA helicases p68 and p72: multifunctional proteins with important implications for cancer development. Future oncology (London, England) 98 21345143
2010 Sumoylation of p68 and p72 RNA helicases affects protein stability and transactivation potential. Biochemistry 97 19995069
2008 p72 DEAD box RNA helicase is required for optimal function of the zinc-finger antiviral protein. Proceedings of the National Academy of Sciences of the United States of America 96 18334637
2010 Multi-talented DEAD-box proteins and potential tumor promoters: p68 RNA helicase (DDX5) and its paralog, p72 RNA helicase (DDX17). American journal of translational research 95 20589163
1996 p72: a human nuclear DEAD box protein highly related to p68. Nucleic acids research 95 8871553
2008 The DEAD box RNA helicases p68 (Ddx5) and p72 (Ddx17): novel transcriptional co-regulators. Biochemical Society transactions 93 18631126
2021 DDX17-regulated alternative splicing that produced an oncogenic isoform of PXN-AS1 to promote HCC metastasis. Hepatology (Baltimore, Md.) 88 34626132
2001 Rearrangement of structured RNA via branch migration structures catalysed by the highly related DEAD-box proteins p68 and p72. Nucleic acids research 87 11353078
2019 Genome comparison of African swine fever virus China/2018/AnhuiXCGQ strain and related European p72 Genotype II strains. Transboundary and emerging diseases 82 30637968
2023 DDX17 induces epithelial-mesenchymal transition and metastasis through the miR-149-3p/CYBRD1 pathway in colorectal cancer. Cell death & disease 81 36593242
2003 The highly related DEAD box RNA helicases p68 and p72 exist as heterodimers in cells. Nucleic acids research 73 12595555
2020 The role of miRNA biogenesis and DDX17 in tumorigenesis and cancer stemness. Biomedical journal 72 32513392
2022 DDX5 and DDX17-multifaceted proteins in the regulation of tumorigenesis and tumor progression. Frontiers in oncology 64 35992805
2012 Dual role of the ddx5/ddx17 RNA helicases in the control of the pro-migratory NFAT5 transcription factor. Oncogene 61 22266867
1990 Mapping and sequence of the gene coding for protein p72, the major capsid protein of African swine fever virus. Virology 61 2327074
2010 Pleiotropic effects of p300-mediated acetylation on p68 and p72 RNA helicase. The Journal of biological chemistry 60 20663877
2007 Intra-genotypic resolution of African swine fever viruses from an East African domestic pig cycle: a combined p72-CVR approach. Virus genes 60 17674176
1994 African swine fever virus structural protein p72 contains a conformational neutralizing epitope. Virology 59 7514322
2019 Regulation of miRNA Biogenesis and Histone Modification by K63-Polyubiquitinated DDX17 Controls Cancer Stem-like Features. Cancer research 55 30877109
2023 A Re-Evaluation of African Swine Fever Genotypes Based on p72 Sequences Reveals the Existence of Only Six Distinct p72 Groups. Viruses 53 38005923
2017 DDX17 nucleocytoplasmic shuttling promotes acquired gefitinib resistance in non-small cell lung cancer cells via activation of β-catenin. Cancer letters 53 28259822
2018 The RNA helicase DDX17 controls the transcriptional activity of REST and the expression of proneural microRNAs in neuronal differentiation. Nucleic acids research 51 29931089
2018 Functions of DEAD box RNA helicases DDX5 and DDX17 in chromatin organization and transcriptional regulation. BMB reports 50 30293550
2018 Linear epitopes in African swine fever virus p72 recognized by monoclonal antibodies prepared against baculovirus-expressed antigen. Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc 48 29327672
2013 The Ddx5 and Ddx17 RNA helicases are cornerstones in the complex regulatory array of steroid hormone-signaling pathways. Nucleic acids research 48 24275493
2021 DDX17 is an essential mediator of sterile NLRC4 inflammasome activation by retrotransposon RNAs. Science immunology 47 34860583
2017 Genetic Assessment of African Swine Fever Isolates Involved in Outbreaks in the Democratic Republic of Congo between 2005 and 2012 Reveals Co-Circulation of p72 Genotypes I, IX and XIV, Including 19 Variants. Viruses 47 28218698
2015 Comparative analysis of the complete genome sequences of Kenyan African swine fever virus isolates within p72 genotypes IX and X. Virus genes 46 25645905
1994 Association of p72 tyrosine kinase with Stat factors and its activation by interleukin-3, interleukin-6, and granulocyte colony-stimulating factor. Blood 46 7515712
2001 The mRNA of DEAD box protein p72 is alternatively translated into an 82-kDa RNA helicase. The Journal of biological chemistry 45 11675387
2022 Development of a p72 trimer-based colloidal gold strip for detection of antibodies against African swine fever virus. Applied microbiology and biotechnology 44 35291024
2019 RNA Specificity and Autoregulation of DDX17, a Modulator of MicroRNA Biogenesis. Cell reports 40 31851931
2002 A bipartite Ca2+-regulated nucleoside-diphosphate kinase system within the Chlamydomonas flagellum. The regulatory subunit p72. The Journal of biological chemistry 39 12095989
1996 Strong sequence conservation of African swine fever virus p72 protein provides the molecular basis for its antigenic stability. Archives of virology 39 8893801
1999 Volume expansion stimulates p72(syk) and p56(lyn) in skate erythrocytes. The Journal of biological chemistry 38 10075687
2024 DEAD-box helicase 17 (DDX17) protects cardiac function by promoting mitochondrial homeostasis in heart failure. Signal transduction and targeted therapy 37 38782919
2022 DDX17 helicase promotes resolution of R-loop-mediated transcription-replication conflicts in human cells. Nucleic acids research 37 36453994
2019 DDX17 promotes hepatocellular carcinoma progression via inhibiting Klf4 transcriptional activity. Cell death & disease 37 31653828
2018 Phylodynamics and evolutionary epidemiology of African swine fever p72-CVR genes in Eurasia and Africa. PloS one 37 29489860
2007 The DEAD-box p68/p72 proteins and the noncoding RNA steroid receptor activator SRA: eclectic regulators of disparate biological functions. Cell cycle (Georgetown, Tex.) 36 17495528
2007 Concerted activation of the Mdm2 promoter by p72 RNA helicase and the coactivators p300 and P/CAF. Journal of cellular biochemistry 35 17226766
1991 Differential regulation of the p72-74 RAF-1 kinase in 3T3 fibroblasts expressing ras or src oncogenes. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 35 1888699
2012 Forced expression of miR-143 represses ERK5/c-Myc and p68/p72 signaling in concert with miR-145 in gut tumors of Apc(Min) mice. PloS one 34 22876303
2023 Identification of p72 epitopes of African swine fever virus and preliminary application. Frontiers in microbiology 31 36819042
2013 The RNA helicase Ddx5/p68 binds to hUpf3 and enhances NMD of Ddx17/p72 and Smg5 mRNA. Nucleic acids research 31 23788676
2022 Development of a Blocking ELISA Kit for Detection of ASFV Antibody Based on a Monoclonal Antibody Against Full-Length p72. Journal of AOAC International 30 35595230
2021 RNA Helicase DDX17 Inhibits Hepatitis B Virus Replication by Blocking Viral Pregenomic RNA Encapsidation. Journal of virology 30 34287051
2016 Upregulation of p72 Enhances Malignant Migration and Invasion of Glioma Cells by Repressing Beclin1 Expression. Biochemistry. Biokhimiia 30 27301285
2015 DDX17 (P72), a Sox2 binding partner, promotes stem-like features conferred by Sox2 in a small cell population in estrogen receptor-positive breast cancer. Cellular signalling 30 26569340
2022 Lateral Flow Assay for the Detection of African Swine Fever Virus Antibodies Using Gold Nanoparticle-Labeled Acid-Treated p72. Frontiers in chemistry 28 35047481
2013 DDX17 promotes the production of infectious HIV-1 particles through modulating viral RNA packaging and translation frameshift. Virology 28 23769241
2013 Nonstructural protein P7-2 encoded by Rice black-streaked dwarf virus interacts with SKP1, a core subunit of SCF ubiquitin ligase. Virology journal 28 24176102
2015 Phylogeographic analysis of African swine fever virus based on the p72 gene sequence. Genetics and molecular research : GMR 27 25966230
2021 DDX17 is involved in DNA damage repair and modifies FUS toxicity in an RGG-domain dependent manner. Acta neuropathologica 26 34061233
1994 p72, a marker protein for melatonin action in ovine pars tuberalis cells: its regulation by protein kinase A and protein kinase C and differential secretion relative to prolactin. Neuroendocrinology 25 8202212
2007 Identification of novel pathway partners of p68 and p72 RNA helicases through Oncomine meta-analysis. BMC genomics 24 18005418
2003 Molecular characterization of a male-specific glycosyl hydrolase, Lma-p72, secreted on to the abdominal surface of the Madeira cockroach Leucophaea maderae (Blaberidae, Oxyhaloinae). The Biochemical journal 24 12593672
1998 Physical and functional interaction between p72(syk) and erythropoietin receptor. The Journal of biological chemistry 24 9852052
2013 Negative effect of P72 polymorphism on p53 gene in IVF outcome in patients with repeated implantation failure and pregnancy loss. Journal of assisted reproduction and genetics 23 24327010
2022 Indirect ELISA Using Multi-Antigenic Dominants of p30, p54 and p72 Recombinant Proteins to Detect Antibodies against African Swine Fever Virus in Pigs. Viruses 22 36560663
2018 Genetic characterisation of African swine fever virus from 2017 outbreaks in Zambia: Identification of p72 genotype II variants in domestic pigs. The Onderstepoort journal of veterinary research 22 30035596
2022 Identification of novel linear epitopes in P72 protein of African swine fever virus recognized by monoclonal antibodies. Frontiers in microbiology 21 36406452
2000 Developmental and tissue-specific expression of DEAD box protein p72. Neuroreport 21 10718294
2019 Blocking tombusvirus replication through the antiviral functions of DDX17-like RH30 DEAD-box helicase. PLoS pathogens 20 31136641
2020 The Significance of Circular RNA DDX17 in Prostate Cancer. BioMed research international 19 32904557
2020 Human DDX17 Unwinds Rift Valley Fever Virus Non-Coding RNAs. International journal of molecular sciences 19 33374561
2022 HBx Mediated Increase of DDX17 Contributes to HBV-Related Hepatocellular Carcinoma Tumorigenesis. Frontiers in immunology 18 35784274
2022 MTDH-stabilized DDX17 promotes tumor initiation and progression through interacting with YB1 to induce EGFR transcription in Hepatocellular Carcinoma. Oncogene 17 36385375
2022 The oncogenic JAG1 intracellular domain is a transcriptional cofactor that acts in concert with DDX17/SMAD3/TGIF2. Cell reports 17 36417870
2016 The loop structure and the RNA helicase p72/DDX17 influence the processing efficiency of the mice miR-132. Scientific reports 17 26947125
2009 Regulation of membrane band 3 Tyr-phosphorylation by proteolysis of p72(Syk) and possible involvement in senescence process. Acta biochimica et biophysica Sinica 17 19779650
2022 DDX17 is required for efficient DSB repair at DNA:RNA hybrid deficient loci. Nucleic acids research 16 36200807
2018 DDX17 Specifically, and Independently of DDX5, Controls Use of the HIV A4/5 Splice Acceptor Cluster and Is Essential for Efficient Replication of HIV. Journal of molecular biology 16 30131116
2002 Reduced levels of DEAD-box proteins DBP-RB and p72 in fetal Down syndrome brains. Neurochemical research 16 12462412
1996 Identification of the polymerase polyprotein products p72 and p65 of the murine coronavirus MHV-JHM. Virus research 16 8896245
2023 Development and characterization of monoclonal antibody against the critical loop structure of african swine fever virus P72 protein. Veterinary microbiology 15 37270924
2022 DDX17 promotes the growth and metastasis of lung adenocarcinoma. Cell death discovery 15 36273228
1993 High-level expression in Escherichia coli of the gene coding for the major structural protein (p72) of African swine fever virus. Gene 15 8428668
2022 THOC5 complexes with DDX5, DDX17, and CDK12 to regulate R loop structures and transcription elongation rate. iScience 14 36590164
2016 The miRNA biogenesis factors, p72/DDX17 and KHSRP regulate the protein level of Ago2 in human cells. Biochimica et biophysica acta 14 27478153
2000 Tyrosine phosphorylation and association of FcgammaRII and p72(Syk) are not limited to the FcgammaRII signalling pathway. Cellular signalling 14 10704823
2024 Nanobodies against African swine fever virus p72 and CD2v proteins as reagents for developing two cELISAs to detect viral antibodies. Virologica Sinica 13 38588947
2023 Development of an effective one-step double-antigen sandwich ELISA based on p72 to detect antibodies against African swine fever virus. Frontiers in veterinary science 13 37360404
2021 An extensive evaluation of codon usage pattern and bias of structural proteins p30, p54 and, p72 of the African swine fever virus (ASFV). Virusdisease 13 34901328
2016 Regulation of the U3-, U8-, and U13snoRNA Expression by the DEAD Box Proteins Ddx5/Ddx17 with Consequences for Cell Proliferation and Survival. Non-coding RNA 13 29657268
2024 A highly efficient blocking ELISA based on p72 monoclonal antibody for the detection of African swine fever virus antibodies and identification of its linear B cell epitope. International journal of biological macromolecules 12 38642684
2022 DDX17 modulates the expression and alternative splicing of genes involved in apoptosis and proliferation in lung adenocarcinoma cells. PeerJ 12 36164607

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