Affinage

BORA

Protein aurora borealis · UniProt Q6PGQ7

Length
559 aa
Mass
61.2 kDa
Annotated
2026-04-28
45 papers in source corpus 17 papers cited in narrative 20 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

BORA is an intrinsically disordered cofactor that functions as the essential scaffold for Aurora A kinase–dependent activation of PLK1 at the G2/M transition, thereby triggering mitotic entry. Accumulating in G2, BORA is phosphorylated by Cyclin A/B–Cdk1 at conserved N-terminal sites (notably Ser112), and by PKA, enabling it to bind Aurora A through TPX2-like motifs whose phospho-Ser112 mimics activation-loop phosphorylation in trans, while simultaneously bridging Aurora A to PLK1 via a conserved C-helix pocket interaction that orients the PLK1 T210 activation loop for phosphorylation (PMID:18566290, PMID:33771996, PMID:41606264, PMID:29870721, PMID:40849432). During mitosis, PLK1 phosphorylates a DSGxxT degron in BORA to recruit SCF-β-TrCP for proteasomal degradation, creating a negative-feedback loop; the DNA damage response independently triggers BORA destruction via ATR-mediated Thr-501 phosphorylation and disrupts Aurora A recruitment to the BORA–PLK1 complex, thereby enforcing G2 arrest (PMID:18378770, PMID:23592782, PMID:27721411). This Cyclin A/Cdk1→BORA→Aurora A→PLK1→Cyclin B/Cdk1 cascade constitutes the triggering event for the bistable switch that commits cells to mitosis, and BORA additionally contributes to meiotic spindle organization and centrosome maturation (PMID:29870721, PMID:23610072).

Mechanistic history

Synthesis pass · year-by-year structured walk · 8 steps
  1. 2006 High

    The initial identification of Bora as a direct activator of Aurora A kinase resolved how Aurora A is switched on at mitotic entry, revealing a cofactor-dependent mechanism conserved from Drosophila to humans.

    Evidence Drosophila bora mutants phenocopy aurora-A; recombinant Bora activates Aurora A in vitro; Bora translocates from nucleus to cytoplasm in a Cdc2-dependent manner

    PMID:16890155

    Open questions at the time
    • Mechanism by which Bora activates Aurora A was unknown
    • Whether Bora acts through PLK1 was not addressed
    • Signal triggering Bora nuclear export not defined beyond Cdc2 dependence
  2. 2008 High

    Two simultaneous studies established that Bora bridges Aurora A to PLK1 to drive PLK1 T210 phosphorylation and mitotic entry, and that PLK1 in turn triggers Bora's own destruction via SCF-β-TrCP, revealing a coupled activation–degradation circuit.

    Evidence Co-IP of Bora with PLK1, reconstituted Aurora A–Bora–PLK1 kinase cascade in vitro, RNAi phenotype; identification of DSGxxT degron phosphorylated by PLK1, Co-IP with β-TrCP, non-degradable mutant delays anaphase

    PMID:18378770 PMID:18566290

    Open questions at the time
    • Structural basis of Bora–Aurora A and Bora–PLK1 interfaces unknown
    • Which Cdk–cyclin complex provides the priming phosphorylation was unresolved
  3. 2013 High

    Multiple regulatory inputs onto Bora were uncovered: ATR-mediated Thr-501 phosphorylation channels DNA-damage signaling into Bora degradation and G2 arrest; a retained mitotic pool sustains PLK1 activity as a bistable switch; and Pin1 binding modulates Bora turnover timing.

    Evidence In vitro ATR kinase assay on Bora T501, Co-IP with β-TrCP, G2 arrest assay; FRET PLK1 biosensor showing persistent Bora–Aurora A dependence in mitosis; Co-IP of Bora with Pin1, mutagenesis of S274/S278

    PMID:23592782 PMID:23970419 PMID:24338364

    Open questions at the time
    • Relative contributions of PLK1- versus ATR-mediated Bora degradation not quantified in vivo
    • Mechanism by which DNA damage disrupts Aurora A–Bora association unclear
  4. 2015 High

    Cdk1 phosphorylation of SPAT-1/Bora was shown to be the conserved priming event that enables Aurora A–dependent PLK1 activation, and a phosphorylation-dependent interaction with MDC1 linked Bora to double-strand break repair.

    Evidence C. elegans CDK-1 phosphosite mutagenesis with in vitro reconstitution of Aurora A–PLK-1 phosphorylation; Co-IP of Bora with MDC1 BRCT domain, γH2AX foci and clonogenic assays

    PMID:25742493 PMID:25753036

    Open questions at the time
    • MDC1 interaction reported by single lab with moderate follow-up
    • Specific Cdk1 phosphosites required for PLK1 activation versus degradation not fully separated
    • Bora's role in DSB repair versus checkpoint signaling not distinguished
  5. 2016 High

    Cyclin B–Cdk1 was identified as the specific Cdk complex phosphorylating Bora's N-terminal sites via conserved cyclin-binding motifs, and the DNA damage response was shown to act by disrupting Aurora A recruitment to the Bora–PLK1 complex rather than breaking the Bora–PLK1 interaction itself.

    Evidence GST pulldown of Bora with Cyclin B, mutagenesis of cyclin-binding motifs and three Sp/Tp sites, FRET biosensor; Aurora A–Bora fusion protein rescues T210 phosphorylation after DNA damage

    PMID:27068477 PMID:27721411

    Open questions at the time
    • Whether Cyclin A and Cyclin B have distinct temporal roles on Bora was not resolved
    • Structural basis of DDR-mediated Aurora A–Bora dissociation unknown
  6. 2018 High

    Cyclin A/Cdk1 phosphorylation of Bora was demonstrated to be the specific triggering event for mitotic commitment, positioning the Cyclin A→Bora→Aurora A→PLK1→Cyclin B/Cdk1 cascade as the core bistable switch for mitotic entry.

    Evidence In vitro Cyclin A/Cdk1 kinase assay on Bora, Xenopus egg extract complementation with phospho-mutant Bora, mathematical modeling of bistability

    PMID:29870721

    Open questions at the time
    • Whether Cyclin A acts exclusively through Bora or has parallel substrates in the switch was not excluded
    • Spatial regulation of Cyclin A/Cdk1–Bora encounter not addressed
  7. 2021 High

    The molecular mechanism of Aurora A activation by Bora was resolved: phospho-Ser112 within a TPX2-like motif substitutes in trans for Aurora A T288 activation-loop phosphorylation, explaining how an intrinsically disordered cofactor allosterically activates a kinase.

    Evidence NMR spectroscopy of Aurora A–Bora interaction, in vitro kinase assay with pSer112 mutants, Xenopus egg extract and human cell validation

    PMID:33771996

    Open questions at the time
    • Full atomic structure of Bora–Aurora A complex not yet determined by X-ray or cryo-EM
    • Whether pSer112 mechanism operates identically in all cell types not tested
  8. 2025 High

    PKA was identified as an additional G2-phase kinase that phosphorylates Bora to enable Aurora A binding, adding a cAMP-dependent input to the mitotic entry switch; simultaneously, NMR-validated structural models of the ternary Aurora A/Bora/PLK1 complex revealed how Bora wraps around Aurora A's N-lobe and bridges to a conserved PLK1 C-helix pocket to orient T210 for phosphorylation.

    Evidence In vitro PKA kinase assay, Co-IP, phospho-mimetic rescue of PKA inhibition, cell-cycle assays; NMR-validated AlphaFold models, 39-variant mutagenesis panel, Xenopus extract reconstitution

    PMID:40849432 PMID:41606264

    Open questions at the time
    • PKA phosphorylation site(s) on Bora and their relationship to Cdk1 sites not fully mapped
    • High-resolution cryo-EM or crystal structure of the full ternary complex still lacking
    • In vivo validation of ternary-complex structural model in mammalian cells not yet reported

Open questions

Synthesis pass · forward-looking unresolved questions
  • Open questions remain regarding the spatial regulation of distinct Bora–PLK1 pools at different cellular structures (centrosomes, kinetochores), the precise hierarchy and interplay of PKA, Cyclin A/Cdk1, and Cyclin B/Cdk1 phosphorylation events on Bora, and whether Bora's interaction with MDC1 reflects a direct role in DNA repair.
  • No high-resolution experimental structure of full-length Bora or complete ternary complex
  • Spatial pools of Bora at centrosomes versus cytoplasm not resolved in vivo
  • Functional significance of Bora–MDC1 interaction in DNA repair remains incompletely characterized

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0098772 molecular function regulator activity 4 GO:0060090 molecular adaptor activity 3
Localization
GO:0005829 cytosol 2 GO:0005634 nucleus 1 GO:0005856 cytoskeleton 1
Pathway
R-HSA-1640170 Cell Cycle 7 R-HSA-162582 Signal Transduction 3 R-HSA-73894 DNA Repair 3
Partners
AURKABTRCCCNA2CCNB1CDK1MDC1PIN1PLK1
Complex memberships
Aurora A–Bora–PLK1 ternary complexSCF-β-TrCP (as substrate)

Evidence

Reading pass · 20 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2006 Bora is required for the activation of Aurora-A at the onset of mitosis; both Drosophila and human Bora bind to Aurora-A and activate the kinase in vitro. In interphase cells Bora is nuclear, but upon mitotic entry it is excluded from the nucleus and translocates to the cytoplasm in a Cdc2-dependent manner, where it can bind and activate Aurora-A. Genetic loss-of-function in Drosophila PNS (bora mutants phenocopy aurora-A), in vitro kinase assay, rescue by Bora overexpression, live-cell fractionation/imaging for localization Developmental Cell High 16890155
2008 Bora accumulates in G2, interacts with Plk1, and controls the accessibility of Plk1's activation loop for phosphorylation (T210) and activation by Aurora A, thereby promoting Cdk1 activation and mitotic entry. Bora and Aurora A act synergistically to activate Plk1. Co-immunoprecipitation of Bora with Plk1, RNAi knockdown, in vitro kinase assay reconstitution, cell cycle staging by FACS Science High 18566290
2008 Plk1 phosphorylates a conserved DSGxxT degron in Bora, promoting its recognition by the SCF-β-TrCP E3 ubiquitin ligase and proteasomal degradation in mitosis. Bora protein peaks in G2 and is degraded during mitosis; a non-degradable Bora variant prolongs metaphase and delays anaphase onset. Co-IP of Bora with β-TrCP, in vitro phosphorylation assay, site-directed mutagenesis of degron, proteasome inhibition, cell cycle synchronization Journal of Cell Biology High 18378770
2010 In C. elegans, SPAT-1 (Bora ortholog) acts with PLK-1 (not AIR-1/Aurora A) to regulate both PAR polarity and cell cycle progression; SPAT-1 binds PLK-1 directly, and depletion of SPAT-1 or PLK-1 produces identical polarity and division defects distinct from those of air-1 depletion. RNAi depletion, Co-IP of SPAT-1 with PLK-1, genetic epistasis (par-2 suppressor rescue), live imaging Development High 20823068
2013 The Bora-Aurora A complex remains the major activator of Plk1 in mitosis; a fraction of Bora is retained in mitosis and is essential for continued Aurora A-dependent T210 phosphorylation of Plk1, functioning as a bistable switch. FRET-based Plk1 activity biosensor, immunoprecipitation, quantitative phospho-immunoblot, Aurora A inhibitor titration Journal of Cell Science High 24338364
2013 ATR phosphorylates Bora at Thr-501 following UV irradiation; phospho-Thr-501 is recognized by SCF-β-TrCP, targeting Bora for ubiquitin-mediated degradation, which compromises Plk1 activation and contributes to DNA-damage-induced G2 arrest. In vitro kinase assay with ATR, Co-IP of Bora with β-TrCP, phospho-specific antibody, site-directed mutagenesis, G2 arrest assay Journal of Biological Chemistry High 23592782
2013 Phosphorylation of Bora at Ser274 and Ser278 is required for Pin1 binding; Pin1 interaction alters Bora's cytoplasmic translocation and promotes premature β-TrCP-mediated degradation, delaying mitotic entry. Aurora A phosphorylates Pin1 at Ser16 to suppress this negative regulation. Co-IP of Bora with Pin1 and Aurora A, site-directed mutagenesis of Bora phosphosites, live-cell imaging of Bora translocation, cell cycle FACS Journal of Cell Science Medium 23970419
2014 Cdk1-mediated phosphorylation of Bora on the consensus site T52 blocks Plk1-mediated Bora degradation in CSF extracts; upon fertilization, Calcineurin dephosphorylates T52, triggering Plx1 activity oscillations, demonstrating that Cdk1 regulates Bora stability through an incoherent feedforward loop. Xenopus CSF extract biochemistry, phospho-specific immunoblot, calcineurin inhibition, site-directed mutagenesis, GFP-Bora degradation assay Cell Cycle Medium 24675888
2015 CDK-1 phosphorylates SPAT-1/Bora at multiple sites to regulate its interaction with PLK-1/Plk1 and trigger mitotic entry in C. elegans embryos; phospho-SPAT-1 promotes Aurora A-mediated PLK-1 T-loop phosphorylation in vitro. This mechanism is conserved: phosphorylation of human Bora by Cdk1 also promotes Aurora A-dependent Plk1 phosphorylation. In vitro kinase assay (CDK-1 on SPAT-1, Aurora A on PLK-1), site-directed mutagenesis of CDK-1 phosphosites in SPAT-1/Bora, C. elegans embryo live imaging, co-IP of SPAT-1 with PLK-1 Journal of Cell Biology High 25753036
2016 Bora interacts with Cyclin B and is phosphorylated by Cyclin B/Cdk1 at three conserved N-terminal Sp/Tp residues; the N-terminus of Bora (first 225 aa) containing two Cyclin binding motifs is sufficient to promote Aurora A-mediated Plk1 phosphorylation in vitro. Mutation of either Cyclin binding sites or the three phosphorylation sites abrogates Plk1 activation and impairs mitotic entry after DNA damage. In vitro kinase assay, GST pulldown of Bora with Cyclin B, site-directed mutagenesis, FRET Plk1 biosensor, C. elegans embryo assay Cell Reports High 27068477
2016 DNA damage inhibits Plk1 activity at T210 by perturbing Aurora A recruitment to the Bora-Plk1 complex, rather than by disrupting the Bora-Plk1 interaction itself. A direct Aurora A-Bora fusion protein prevents DNA-damage-induced loss of Plk1 T210 phosphorylation, demonstrating that the DDR targets Aurora A-Bora association. FRET-based Plk1 activity biosensor, Aurora A-Bora fusion construct, Co-IP, phospho-specific immunoblot for T210 Oncogene High 27721411
2018 Cyclin A/Cdk1 phosphorylates Bora to promote Aurora A-dependent Plk1 activation and mitotic entry; phosphorylation of a specific site in Bora by Cyclin A/Cdk1 is both necessary and sufficient for mitotic commitment, constituting the triggering event for the cyclin B/Cdk1 bistable switch. In vitro kinase assay (Cyclin A/Cdk1 on Bora, Aurora A on Plk1), site-directed mutagenesis, Xenopus egg extract complementation, mathematical modeling Developmental Cell High 29870721
2021 Phospho-Bora (phosphorylated by CyclinA/B-Cdk1 at Ser112) is a direct activator of Aurora A kinase activity; the phospho-Ser112-Pro motif within a TPX2-like region substitutes in trans for Aurora A T288 activation-loop phosphorylation to stabilize the active kinase conformation. Two short TPX2-like motifs and pSer112 in the first ~100 aa of Bora are the key determinants. In vitro kinase assay, site-directed mutagenesis, NMR spectroscopy, structural modeling, Xenopus egg extract reconstitution, human cell functional assay Nature Communications High 33771996
2015 Bora specifically interacts with the tandem BRCT domain of MDC1 in a phosphorylation-dependent manner after irradiation; overexpression of Bora abolishes irradiation-induced MDC1 foci formation, and Bora knockdown accelerates DSB repair, conferring radioresistance. Co-IP of Bora with MDC1, clonogenic survival assay, γH2AX foci assay, knockdown by siRNA PLOS ONE Medium 25742493
2013 Bora localizes to meiotic spindles in mouse oocytes (co-localizing with α-tubulin at prometaphase/metaphase but dissociating at anaphase/telophase); depletion or inhibition of Bora causes defective spindle morphology, chromosome misalignment, and arrest at prometaphase/metaphase-I, with loss of Aurora A and Plk1 at the spindle. Immunofluorescence co-localization, siRNA microinjection, anti-Bora antibody microinjection, live imaging of GVBD and polar body extrusion Molecular Reproduction and Development Medium 23610072
2025 cAMP-dependent protein kinase (PKA) phosphorylates Bora during G2 phase, enabling Bora to bind Aurora A and recruit it to the Bora-Plk1 complex, thereby facilitating Aurora A-dependent Plk1 activation and G2/M transition. Disruption of PKA-mediated Bora phosphorylation impairs Plk1 activation; a phospho-mimetic Bora mutant bypasses PKA requirement. In vitro kinase assay (PKA on Bora), Co-IP of Bora with Aurora A, site-directed mutagenesis (phospho-mimetic and phospho-null Bora), Plk1 activity assay, cell cycle synchronization, DNA damage checkpoint recovery assay Nature Communications Medium 40849432
2026 Structural models of the Aurora A/Bora and Aurora A/Bora/PLK1 ternary complex validated by NMR and mutagenesis show that Bora wraps around the N-lobe of Aurora A, with pSer112 mimicking T-loop phosphorylation. In the ternary complex Bora bridges both kinases, orienting PLK1's activation loop toward Aurora A's active site via Bora residues 56-66 engaging a conserved C-helix pocket on PLK1 analogous to the TPX2-binding Y-pocket of Aurora A. Aurora A phosphorylation of Bora Ser59 creates an additional interface that increases PLK1 phosphorylation efficiency. NMR spectroscopy, site-specific mutagenesis, in vitro biochemical assay, structural modeling (AlphaFold-based validated models) EMBO Reports High 41606264
2025 Bora is the main driver of Plk1 activation for mitotic entry, DNA-damage recovery, and centrosome maturation, while centriole disengagement is primarily regulated by Cep192 and Cenexin, demonstrating that distinct Plk1 co-activators control different cell cycle steps via spatially distinct Plk1 pools in human cells. siRNA knockdown of individual Plk1 co-activators (Bora, Cep192, Cenexin), FRET Plk1 biosensor, live-cell imaging, centrosome maturation and centriole disengagement assays bioRxivpreprint Medium
2025 Aurora A:Bora complex specifically phosphorylates PLK1 T210 in vitro, whereas Aurora A alone, other Aurora A:activator complexes, and Aurora B:INCENP fail to phosphorylate T210. A transient Bora-PLK1 interaction identified by structural modeling and confirmed by mutagenesis is uniquely required for T210 phosphorylation; mutating PLK1 Lys208 to Arg eliminates Bora dependency and allows phosphorylation by multiple Aurora kinases. In vitro kinase assay reconstitution with purified components, structural modeling, site-directed mutagenesis of Bora-PLK1 interface and PLK1 Lys208 bioRxivpreprint Medium
2025 Structural modeling (AlphaFold3) and E. coli reconstitution assay show that phospho-Bora wraps around the N-terminal lobe of Aurora A, positioning pSer112 in Aurora A's activation loop to mimic T-loop phosphorylation; Bora additionally bridges Aurora A activity to the PLK1 T-loop via a conserved motif interacting with the PLK1 alpha-C helix, which is otherwise impervious to Aurora A phosphorylation. E. coli-based reconstitution of Bora-Aurora A-dependent Plk1 T-loop phosphorylation (MITOKINAC), AlphaFold3 structural modeling, 39-variant mutagenesis panel, Xenopus egg extract assay bioRxivpreprint Medium

Source papers

Stage 0 corpus · 45 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2008 Bora and the kinase Aurora a cooperatively activate the kinase Plk1 and control mitotic entry. Science (New York, N.Y.) 508 18566290
2011 Triple antiretroviral compared with zidovudine and single-dose nevirapine prophylaxis during pregnancy and breastfeeding for prevention of mother-to-child transmission of HIV-1 (Kesho Bora study): a randomised controlled trial. The Lancet. Infectious diseases 315 21237718
2018 Long-term safety and efficacy of benralizumab in patients with severe, uncontrolled asthma: 1-year results from the BORA phase 3 extension trial. The Lancet. Respiratory medicine 227 30416083
2006 Mitotic activation of the kinase Aurora-A requires its binding partner Bora. Developmental cell 156 16890155
2008 Plk1- and beta-TrCP-dependent degradation of Bora controls mitotic progression. The Journal of cell biology 120 18378770
2013 Bora and Aurora-A continue to activate Plk1 in mitosis. Journal of cell science 91 24338364
2018 Cyclin A-cdk1-Dependent Phosphorylation of Bora Is the Triggering Factor Promoting Mitotic Entry. Developmental cell 84 29870721
2015 Cdk1 phosphorylates SPAT-1/Bora to trigger PLK-1 activation and drive mitotic entry in C. elegans embryos. The Journal of cell biology 51 25753036
2016 Cdk1 Phosphorylates SPAT-1/Bora to Promote Plk1 Activation in C. elegans and Human Cells. Cell reports 46 27068477
2010 SPAT-1/Bora acts with Polo-like kinase 1 to regulate PAR polarity and cell cycle progression. Development (Cambridge, England) 45 20823068
2021 Bora phosphorylation substitutes in trans for T-loop phosphorylation in Aurora A to promote mitotic entry. Nature communications 39 33771996
2011 Synthesis and characterization of high-affinity 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene-labeled fluorescent ligands for human β-adrenoceptors. Journal of medicinal chemistry 39 21870877
2010 Crystallographic, photophysical, NMR spectroscopic and reactivity manifestations of the "8-heteroaryl effect" in 4,4-difluoro-8-(C(4)H(3)X)-4-bora-3a,4a-diaza-s-indacene (X = O, S, Se) (BODIPY) systems. Inorganic chemistry 39 20420417
2007 Use of fluorescence-activated flow cytometry to determine membrane lipid peroxidation during hypothermic liquid storage and freeze-thawing of viable boar sperm loaded with 4, 4-difluoro-5-(4-phenyl-1,3-butadienyl)-4-bora-3a,4a-diaza-s-indacene-3-undecanoic acid. Journal of animal science 39 17296775
2016 Inhibition of Polo-like kinase 1 during the DNA damage response is mediated through loss of Aurora A recruitment by Bora. Oncogene 36 27721411
2013 Pin1 acts as a negative regulator of the G2/M transition by interacting with the Aurora-A-Bora complex. Journal of cell science 35 23970419
2016 Mitotic entry: The interplay between Cdk1, Plk1 and Bora. Cell cycle (Georgetown, Tex.) 33 27831827
2009 Comparison of the Generic HIV Viral Load assay with the Amplicor HIV-1 monitor v1.5 and Nuclisens HIV-1 EasyQ v1.2 techniques for plasma HIV-1 RNA quantitation of non-B subtypes: the Kesho Bora preparatory study. Journal of virological methods 33 19837114
2013 Ataxia telangiectasia-mutated- and Rad3-related protein regulates the DNA damage-induced G2/M checkpoint through the Aurora A cofactor Bora protein. The Journal of biological chemistry 32 23592782
1997 Synthesis and characterization of 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY)-labeled fluorescent ligands for the mu opioid receptor. Biochemical pharmacology 25 9393674
2011 4,4-Difluoro-4-bora-3a,4a-diaza-s-indacene as a bright fluorescent label for DNA. The Journal of organic chemistry 20 21381720
2008 Uncoupled protein 3 and p38 signal pathways are involved in anti-obesity activity of Solanum tuberosum L. cv. Bora Valley. Journal of ethnopharmacology 20 18579324
2017 Synthesis and Spectroscopic and Cellular Properties of Near-IR [a]Phenanthrene-Fused 4,4-Difluoro-4-bora-3a,4a-diaza-s-indacenes. The Journal of organic chemistry 18 28845980
2014 Phosphorylation-mediated stabilization of Bora in mitosis coordinates Plx1/Plk1 and Cdk1 oscillations. Cell cycle (Georgetown, Tex.) 16 24675888
2020 Phylogenetic relationships of three Kudoa spp. with morphologically similar myxospores (K. iwatai, K. lutjanus, and K. bora), with the redescription of K. uncinata and K. petala and description of a new species (K. fujitai n. sp.) in fishes in the South China Sea. Parasitology research 14 32179988
2020 Aurora Borealis (Bora), Which Promotes Plk1 Activation by Aurora A, Has an Oncogenic Role in Ovarian Cancer. Cancers 14 32268485
2019 Doxorubicin loaded carboxymethyl Assam bora rice starch coated superparamagnetic iron oxide nanoparticles as potential antitumor cargo. Heliyon 14 31294107
2013 Infant feeding modes and determinants among HIV-1-infected African Women in the Kesho Bora Study. Journal of acquired immune deficiency syndromes (1999) 14 23075919
2014 Interactions of "bora-penicilloates" with serine β-lactamases and DD-peptidases. Biochemistry 9 25302576
2020 Bacillus thuringiensis strains isolated from Qatari soil, synthesizing δ-endotoxins highly active against the disease vector insect Aedes aegypti Bora Bora. Heliyon 8 33163639
2015 Cdk1 plays matchmaker for the Polo-like kinase and its activator SPAT-1/Bora. Cell cycle (Georgetown, Tex.) 8 26038951
2013 Bora regulates meiotic spindle assembly and cell cycle during mouse oocyte meiosis. Molecular reproduction and development 8 23610072
2020 BORA regulates cell proliferation and migration in bladder cancer. Cancer cell international 6 32655322
2015 Bora downregulation results in radioresistance by promoting repair of double strand breaks. PloS one 6 25742493
2018 Cyclin A Turns on Bora to Light the Path to Mitosis. Developmental cell 4 29870714
2026 Bora bridges Aurora-A activation and substrate recognition of PLK1. EMBO reports 3 41606264
2022 Citric acid esterified Glutinous Assam bora rice starch enhances disintegration and dissolution efficiency of model drug. International journal of biological macromolecules 3 36549610
2025 The cAMP-PKA signaling initiates mitosis by phosphorylating Bora. Nature communications 2 40849432
2024 Tanshinone T1/T2A inhibits non-small cell lung cancer through Lin28B-let-7-BORA/MYC regulatory network. Gene 2 39481768
2016 BORA-dependent PLK1 regulation: A new weapon for cancer therapy? Molecular & cellular oncology 2 27857970
2017 Hydrogen Liberation from Gaseous 2-Bora-1,3-diazacycloalkanium Cations. The journal of physical chemistry. A 1 28934854
1993 [The mechanisms of the antiviral action of the bora-adamantane derivative preparation BG-12]. Voprosy virusologii 1 8073750
2026 Cooking and eating quality of ethnic Bora rice (Oryza sativa L.): machine learning-based prediction of resistant starch content in ready-to-eat products. Journal of the science of food and agriculture 0 41562155
2026 Mitotic entry: Bora takes Polo to Aurora, and gives them a hug. The EMBO journal 0 41606195
2023 Synthesis and In Vitro Biocompatibility Studies of Novel Alkoxy 4,4-Difluoro-4-bora-3a,4a-diaza-s-indacenes. Materials (Basel, Switzerland) 0 38005015