Affinage

BCL11B

B-cell lymphoma/leukemia 11B · UniProt Q9C0K0

Length
894 aa
Mass
95.5 kDa
Annotated
2026-06-09
100 papers in source corpus 41 papers cited in narrative 41 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 8/9 claims corpus-supported (89%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

BCL11B (CTIP2) is a C2H2 zinc finger transcription factor that acts as a context-dependent transcriptional repressor and activator governing cell-fate decisions across the immune, nervous, and epithelial systems (PMID:27376470, PMID:30374131). Its repressive activity is executed through recruitment of chromatin-modifying machinery: BCL11B associates with the NuRD complex via direct interaction with RbAp46/RbAp48 to confer histone deacetylase activity at target promoters (PMID:16950772), recruits HDAC1/HDAC2 and cooperates with SUV39H1 to deposit H3K9 methylation and enable HP1-dependent heterochromatin formation (PMID:17245431, PMID:19581932), and partners with the LSD1 demethylase to silence transcription (PMID:22067449). BCL11B homodimerizes through its N-terminal CCHC zinc finger, a domain necessary and sufficient for dimerization and required for its transcription-regulatory, cell-cycle-arrest, and anti-apoptotic functions (PMID:29203643). Beyond chromatin silencing, BCL11B negatively regulates transcriptional elongation by associating with an inactive 7SK snRNP/HEXIM1 complex to repress P-TEFb/Cdk9 kinase activity, an inhibitory complex recruited to promoters by HMGA1 (PMID:23852730, PMID:24623795). Its repressor-versus-activator output is switched by post-translational modification: PKC-mediated phosphorylation at Ser2 dampens NuRD (MTA1/MTA3/RbAp46) binding and instead recruits P300 to convert BCL11B into an activator at target promoters such as IL-2 and Id2 (PMID:27161321). In T-lineage commitment, BCL11B is activated by an asynchronous combinatorial mechanism integrating TCF-1/GATA-3 locus poising, Notch-dependent stochastic permissivity, and Runx1 amplitude control (PMID:27376470), after which it collaborates with RUNX1 to maintain mSWI/SNF occupancy and poise effector chromatin landscapes (PMID:38632339), and represses Id2 and Zbtb16 to block alternative innate lymphoid, NK, and NKT fates (PMID:30374131). This innate-fate-restricting role recurs across lymphoid lineages including ILC2s, Treg cells, NK cells, tissue-resident memory CD8+ T cells, and in suppressing NK-like reprogramming of T cells via NuRD (PMID:26231117, PMID:25964370, PMID:31457080, PMID:33712472, PMID:37115913, PMID:37737560). In the nervous system, BCL11B acts downstream of Fezf2 to specify subcortical projection neuron identity (PMID:18678899), drives striatal medium spiny neuron differentiation and PKA signaling (PMID:18199763, PMID:31447328), directs hippocampal neurogenesis through its direct target Desmoplakin (PMID:22588081), and controls mossy fiber-CA3 synapse function via a C1ql2/Nrxn3(25b+) pathway (PMID:38358390). BCL11B binding sites, motif preferences, partner complexes, and post-translational modifications are cell-type-specific, explaining how a single factor controls distinct gene programs in different lineages (PMID:31653691).

Mechanistic history

Synthesis pass · year-by-year structured walk · 25 steps
  1. 2003 High

    Established BCL11B as an essential regulator of early thymocyte development, answering whether it had a non-redundant role in T-lineage differentiation and survival.

    Evidence Bcl11b knockout mice with flow cytometry and Tcrb PCR

    PMID:12717433

    Open questions at the time
    • Did not define the molecular mechanism of Tcrb regulation
    • Direct target genes not identified
  2. 2003 High

    Showed BCL11B operates through heterochromatin association, linking it to HP1alpha and silencing of HIV-1 by sequestering Tat into inactive chromatin.

    Evidence Co-IP, confocal microscopy, and domain-mapping deletion mutants in microglial cells

    PMID:12692243

    Open questions at the time
    • Cellular gene targets of HP1-bound BCL11B not addressed
    • Mechanism of recruitment to chromatin not defined
  3. 2006 High

    Defined the molecular basis of BCL11B repression by mapping a direct interaction with NuRD subunits RbAp46/48 that confers HDAC activity to BCL11B complexes.

    Evidence Co-IP, ChIP at p57KIP2, and HDAC activity assays in neuroblastoma cells

    PMID:16950772

    Open questions at the time
    • Did not establish whether NuRD recruitment is universal across target genes
    • Other NuRD subunit contacts not mapped
  4. 2007 High

    Resolved the chromatin-silencing mechanism by showing BCL11B recruits HDAC1/2 and cooperates with SUV39H1 for H3K9 methylation and HP1-mediated heterochromatin.

    Evidence Reciprocal Co-IP, ChIP, and reporter assays at the HIV-1 promoter

    PMID:17245431

    Open questions at the time
    • Order of HDAC versus methyltransferase recruitment unresolved
    • Generalization beyond HIV-1 promoter not tested here
  5. 2007 High

    Extended BCL11B function to positive selection of both T-cell lineages, tying its survival role to proximal TCR signaling competence.

    Evidence Conditional KO mice with calcium flux, ERK phosphorylation, and TCR transgene rescue

    PMID:17998389

    Open questions at the time
    • Direct transcriptional targets controlling TCR signaling not identified
    • Link to chromatin machinery not made
  6. 2008 High

    Placed Bcl11b genetically downstream of Fezf2 in cortical subcortical projection neuron fate specification, defining a CNS developmental pathway.

    Evidence Fezf2 KO mice, in utero electroporation, axonal tracing, and double-mutant epistasis

    PMID:18678899

    Open questions at the time
    • Direct Bcl11b target genes in this fate decision not defined
    • Cofactor requirements unknown
  7. 2008 High

    Identified Bcl11b as a master regulator of striatal medium spiny neuron differentiation and architecture.

    Evidence Ctip2 KO mice, immunohistochemistry, and striatal histology

    PMID:18199763

    Open questions at the time
    • Whether downstream markers are direct targets not established
    • Mechanism of patch aggregation control unknown
  8. 2009 High

    Generalized the SUV39H1-cooperative silencing mechanism to the cell-cycle gene p21, linking BCL11B to proliferation control.

    Evidence ChIP, chaetocin inhibition, siRNA, and cell cycle analysis

    PMID:19581932

    Open questions at the time
    • Direct BCL11B binding to p21 promoter versus indirect recruitment not fully separated
  9. 2012 High

    Defined Bcl11b as a direct transcriptional driver of hippocampal neurogenesis via its target Desmoplakin, established by rescue.

    Evidence Forebrain-specific KO, ChIP, Desmoplakin rescue, and behavioral testing

    PMID:22588081

    Open questions at the time
    • Cofactors mediating Desmoplakin regulation not identified
  10. 2012 Medium

    Revealed BCL11B as a bidirectional context-dependent regulator in epithelial development, controlling FGF/TGFbeta/Shh networks and epidermal lipid metabolism.

    Evidence Tissue-specific conditional KO, ChIP, and lipidomics across incisor and epidermis

    PMID:22629441 PMID:23015591 PMID:23096701

    Open questions at the time
    • Direct versus indirect target distinction incomplete for some networks
    • PTM-driven degradation (calcium, SUMO/ubiquitin) mechanistic detail limited to single lab
  11. 2013 High

    Discovered a non-chromatin repressive mechanism: BCL11B sequesters P-TEFb in an inactive 7SK/HEXIM1 complex to repress Cdk9 and elongation, with disease relevance in cardiac hypertrophy.

    Evidence Co-purification, Cdk9 kinase assay, ChIP at MYH7, and hypertrophic heart model

    PMID:23852730

    Open questions at the time
    • How BCL11B is recruited to the 7SK snRNP initially not resolved here
  12. 2014 Medium

    Identified HMGA1 as the recruiting factor delivering the inactive BCL11B/P-TEFb complex to promoters, solving the recruitment question.

    Evidence ChIP and combinatorial siRNA knockdown of HMGA1 and CTIP2

    PMID:24623795

    Open questions at the time
    • Direct HMGA1-BCL11B contact versus bridging not fully mapped
    • Single lab
  13. 2014 Medium

    Showed Ctip2 directly represses Unc5C in cortical neurons to control corticofugal axon projection via the Netrin1-Unc5C axis.

    Evidence Conditional KO, ChIP, axonal tracing, and Unc5C epistasis

    PMID:24739528

    Open questions at the time
    • Single lab
    • Cofactor mediating Unc5C repression unknown
  14. 2016 High

    Defined how Bcl11b expression is itself switched on, revealing an asynchronous combinatorial logic of TCF-1/GATA-3 poising, Notch permissivity, and Runx1 amplitude control.

    Evidence Single-cell live imaging with knock-in reporter and genetic perturbations

    PMID:27376470

    Open questions at the time
    • Molecular nature of the stochastic Notch step not resolved
    • How inputs converge at the locus mechanistically unclear
  15. 2016 High

    Established a PTM-driven repressor-to-activator switch: PKC phosphorylation at Ser2 trades NuRD binding for P300 recruitment at the same promoters.

    Evidence Endogenous MTA1/MTA3 Co-IP, phospho-specific antibodies, and ChIP in primary human CD4+ T cells

    PMID:27161321

    Open questions at the time
    • Structural basis of how Ser2 phosphorylation alters cofactor affinity unknown
    • Whether other PTMs tune the switch not addressed here
  16. 2016 High

    Demonstrated that Bcl11b maintains innate lymphoid identity, being required for ILC2 development and suppression of the ILC3/RORgt program.

    Evidence Reporter and conditional KO mice, fetal liver chimeras, ChIP for Ahr, and infection models

    PMID:25964370 PMID:26231117

    Open questions at the time
    • Cofactor complexes in ILC2s not defined in these studies
    • Direct versus indirect control of Gata3 not fully resolved
  17. 2018 High

    Mapped BCL11B homodimerization to the N-terminal CCHC zinc finger and showed it is required for transcriptional regulation, cell-cycle arrest, and apoptosis protection.

    Evidence FACS-FRET, AP-MS, and point mutagenesis with functional assays

    PMID:29203643

    Open questions at the time
    • Structural model of the dimer interface not determined
    • Whether heterodimerization with paralogs occurs not tested
  18. 2018 High

    Defined the genome-wide cofactor landscape in pro-T cells, identifying RUNX1 as the most frequent collaborator and Id2/Zbtb16 as direct repressed targets controlling innate fate exclusion.

    Evidence AP-MS, ChIP-seq, RNA-seq, and stage-specific cofactor-deletion epistasis

    PMID:30374131

    Open questions at the time
    • Mechanism dictating activation versus repression at individual RUNX1-shared sites unresolved
  19. 2018 High

    Showed Bcl11b physically binds GATA3 and co-regulates Th2 cytokine genes, maintaining chromatin states at the Th2 locus and restricting Runx3.

    Evidence Co-IP, ChIP-seq, ATAC-seq, and GATA3-dependence epistasis in Th2 cells

    PMID:29514917 PMID:29700302

    Open questions at the time
    • Whether GATA3 interaction uses the same surface as NuRD not addressed
  20. 2019 High

    Demonstrated that Bcl11b restrains innate lineage programs in Treg cells through direct binding overlapping Foxp3 and chromatin accessibility control.

    Evidence Treg-specific KO, ChIP-seq, ATAC-seq, and autoimmunity phenotype

    PMID:31457080

    Open questions at the time
    • Direct cooperativity with Foxp3 protein not biochemically tested here
  21. 2019 Medium

    Extended Bcl11b's binary-switch logic to olfactory receptor class choice and PKA signaling integration in human MSNs with Huntington's disease relevance.

    Evidence LOF/GOF mice and J-element analysis; transcriptomics and phospho-analysis of CTIP2-deficient human iPSC-MSNs

    PMID:31396576 PMID:31447328

    Open questions at the time
    • Single lab for each
    • Direct target genes in PKA integration not fully mapped
  22. 2020 High

    Established the principle that Bcl11b uses cell-type-specific motifs, PTMs, and partner complexes to control entirely different gene sets in pro-T cells versus ILC2s.

    Evidence Comparative ChIP-seq, proteomics, and conditional cell-type-specific KO

    PMID:31653691

    Open questions at the time
    • What dictates cell-type-specific motif selection mechanistically unknown
  23. 2023 High

    Linked BCL11B/NuRD repression of NK-cell fate in T cells to mitochondrial metabolism and acetyl-CoA-driven H3K27 acetylation, connecting metabolism to its epigenetic output.

    Evidence Co-IP, NuRD subunit and BCL11B deletion, metabolic profiling, and H3K27ac ChIP in human T cells

    PMID:37737560

    Open questions at the time
    • Direct metabolic targets of repression not all identified
  24. 2024 High

    Defined a PU.1-to-BCL11B 'relay' maintaining mSWI/SNF and RUNX1 occupancy that poises the T effector chromatin landscape before TCR expression.

    Evidence ATAC-seq and ChIP-seq for BCL11B/RUNX1/PU.1/mSWI/SNF with stage-specific conditional KO

    PMID:38632339

    Open questions at the time
    • Biochemical basis of the handoff between PU.1 and BCL11B not resolved
  25. 2024 High

    Connected Bcl11b to synaptic function by identifying C1ql2 as a direct target acting through Nrxn3(25b+) to control mossy fiber-CA3 LTP.

    Evidence ChIP, conditional KO, LTP electrophysiology, C1ql2-Nrxn3 Co-IP, and non-binding mutant rescue

    PMID:38358390

    Open questions at the time
    • Cofactors mediating C1ql2 activation not identified

Open questions

Synthesis pass · forward-looking unresolved questions
  • How BCL11B integrates cell-type-specific PTMs, dimerization state, and partner availability to choose between repressive (NuRD/SUV39H1/P-TEFb) and activating (P300/mSWI/SNF) outputs at specific loci remains unresolved.
  • No structural model linking PTM state to cofactor choice
  • Rules governing cell-type-specific motif and complex selection unknown
  • Direct DNA-binding specificity at endogenous targets not biochemically defined across lineages

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0003677 DNA binding 5 GO:0140110 transcription regulator activity 5 GO:0042393 histone binding 2 GO:0098772 molecular function regulator activity 2
Localization
GO:0005634 nucleus 5 GO:0000228 nuclear chromosome 2
Pathway
R-HSA-168256 Immune System 8 R-HSA-1266738 Developmental Biology 5 R-HSA-4839726 Chromatin organization 5 R-HSA-74160 Gene expression (Transcription) 4 R-HSA-1640170 Cell Cycle 3
Partners
GATA3HEXIM1HMGA1MTA1RBBP4RBBP7RUNX1SUV39H1
Complex memberships
NuRD complexinactive 7SK snRNP/HEXIM1/P-TEFb complexmSWI/SNF

Evidence

Reading pass · 41 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2003 Bcl11b is required for V(beta) to D(beta) recombination and Tcrb mRNA expression in thymocytes; Bcl11b-deficient mice show a developmental block at the CD4-CD8 double-negative stage with absent pre-TCR complex on the cell surface and profound apoptosis, establishing Bcl11b as a key regulator of both differentiation and survival during thymocyte development. Bcl11b knockout mouse model; flow cytometry; PCR for Tcrb expression Nature immunology High 12717433
2007 CTIP2 (BCL11B) recruits histone deacetylases HDAC1 and HDAC2 to promote local histone H3 deacetylation at the HIV-1 promoter, and associates with histone methyltransferase SUV39H1 to increase local H3K9 methylation, enabling HP1 protein recruitment and heterochromatin formation to silence HIV-1 transcription in microglial cells. Co-immunoprecipitation; chromatin immunoprecipitation (ChIP); reporter assays; confocal microscopy in microglial cells The EMBO journal High 17245431
2003 CTIP2 colocalizes and physically associates with heterochromatin protein HP1alpha, and forms a three-protein complex with HIV-1 Tat via two distinct CTIP2 domains (residues 145-434 for Tat binding, 717-813 for HP1 binding), recruiting Tat into inactive chromatin regions and inhibiting Tat-mediated transactivation of HIV-1 in microglial cells. Co-immunoprecipitation; confocal microscopy; deletion mutant analysis; HIV-1 replication assays Journal of virology High 12692243
2006 CTIP2 associates with the NuRD complex through direct interaction with RbAp46 and RbAp48 subunits, confers histone deacetylase activity to CTIP2 complexes, and co-occupies the p57KIP2 promoter with NuRD components to repress p57KIP2 transcription in neuroblastoma cells. Co-immunoprecipitation; chromatin immunoprecipitation (ChIP); HDAC activity assays; reporter assays in SK-N-MC cells The Journal of biological chemistry High 16950772
2007 BCL11B is required for positive selection of both CD4 and CD8 T cell lineages in double-positive thymocytes; BCL11B-deficient DP thymocytes display impaired proximal TCR signaling, attenuated ERK phosphorylation and calcium flux, and increased spontaneous apoptosis associated with elevated cleaved caspase-3 and altered pro-apoptotic/pro-survival factor balance. Conditional BCL11B knockout mice; flow cytometry; calcium flux assays; ERK phosphorylation assays; TCR transgene rescue experiments The Journal of experimental medicine High 17998389
2008 Ctip2 is a major downstream effector of Fezf2 in specifying subcortical projection neuron fate in the cerebral cortex; ectopic Ctip2 expression redirects callosal projection neurons to project subcortically, and Ctip2 can rescue the axonal phenotype of Fezf2 mutants, placing Ctip2 genetically downstream of Fezf2 in this pathway. Fezf2 knockout mice; in utero electroporation; axonal tracing; epistasis analysis with double mutants Proceedings of the National Academy of Sciences of the United States of America High 18678899
2008 Ctip2 is required for differentiation of striatal medium spiny neurons (MSN); in its absence, MSN markers including DARPP-32, FOXP1, Chrm4, and Plexin-D1 are dramatically reduced, MSN fail to aggregate into patches, and dopaminergic innervation is abnormal, establishing Ctip2 as a critical regulator of MSN differentiation and striatal architecture. Ctip2 knockout mice; immunohistochemistry; gene expression analysis; histological analysis of striatal organization The Journal of neuroscience High 18199763
2009 CTIP2 silences the p21(WAF1) gene promoter by recruiting histone deacetylases and cooperating with SUV39H1 histone methyltransferase; CTIP2 and SUV39H1 co-occupy the silenced p21 promoter and cooperatively inhibit p21 transcription through histone H3K9 trimethylation, and CTIP2 abolishes Vpr-mediated stimulation of p21. ChIP; pharmacological inhibition with chaetocin (SUV39H1 inhibitor); reporter assays; siRNA knockdown; cell cycle analysis Oncogene High 19581932
2011 LSD1 histone demethylase cooperates with CTIP2 to repress HIV-1 transcription in a synergistic manner; LSD1 recruitment to the HIV-1 proximal promoter is associated with both H3K4me3 and H3K9me3 epigenetic marks. ChIP; siRNA knockdown of LSD1; reporter assays; viral expression assays in microglial cells Nucleic acids research Medium 22067449
2012 Bcl11b/Ctip2 plays a dual role in hippocampal neurogenesis: it controls feedback regulation of the progenitor cell compartment and regulates granule cell differentiation. Desmoplakin is identified as a direct transcriptional target of Bcl11b, and re-expression of Desmoplakin in Bcl11b mutants rescues impaired neurogenesis, placing Bcl11b upstream of Desmoplakin in hippocampal development. Forebrain-specific Bcl11b knockout mice; ChIP for direct target identification; Desmoplakin rescue experiment; behavioral testing (spatial learning) The EMBO journal High 22588081
2013 CTIP2 is a negative regulator of P-TEFb activity; CTIP2 copurifies and interacts with an inactive P-TEFb complex containing 7SK snRNA and HEXIM1, associating directly with HEXIM1 and via the loop 2 of 7SK snRNA with P-TEFb, and significantly represses Cdk9 kinase activity. In hypertrophic cardiomyopathic mouse hearts, the inactive P-TEFb/CTIP2 complex associates with the MYH7 gene promoter to repress its activity. Co-purification; Co-immunoprecipitation; Cdk9 kinase activity assay; ChIP at MYH7 promoter; RNA-seq; siRNA knockdown Proceedings of the National Academy of Sciences of the United States of America High 23852730
2013 BCL11B acts as a transcriptional repressor in Ewing sarcoma and contributes to the EWS/FLI repressed gene signature; its repressive activity is mediated through the NuRD co-repressor complex. Re-expression of SPRY1, a repressed BCL11B target, limits transformation in Ewing sarcoma cells. siRNA knockdown; gene expression profiling; reporter assays; Co-immunoprecipitation for NuRD complex association PloS one Medium 23527175
2014 HMGA1 recruits the CTIP2-repressed inactive P-TEFb/7SK snRNP complex to cellular gene promoters and the HIV-1 promoter; HMGA1 knockdown reduces ChIP signals for CTIP2, 7SK, and P-TEFb at target promoters, revealing HMGA1 as the recruiting mechanism for the inactive P-TEFb complex. ChIP; siRNA knockdown of HMGA1 and CTIP2; reporter assays for HIV-1 and cellular promoters Nucleic acids research Medium 24623795
2014 Unc5C expression is under direct negative regulation by Ctip2 in cortical neurons; Ctip2 directly represses Unc5C, and the Netrin1-Unc5C interaction downstream of Ctip2 controls corticofugal axon projections. Conditional knockout mice; ChIP (direct regulation); axonal tracing; epistasis analysis Nature communications Medium 24739528
2015 Bcl11b acts directly upstream of Gfi1 to maintain its expression in mature ILC2s, and independently represses expression of the ILC3 transcription factor Ahr; Bcl11b-deficient ILC2s downregulate Gata3 and downstream IL-33 receptor, and upregulate Rorc and ILC3 genes, demonstrating a dual role in maintaining ILC2 identity and suppressing ILC3 programming. Conditional Bcl11b knockout mice; gene expression analysis; flow cytometry; functional cytokine production assays; ChIP for direct Ahr repression Immunity High 26231117
2015 Bcl11b is wholly required for ILC2 development; in vivo deletion of Bcl11b abolishes ILC2 generation with concomitant expansion of RORγt+ ILC3 population, suggesting Bcl11b negatively regulates the ILC3 lineage. Bcl11b reporter mice; conditional tamoxifen-induced deletion; fetal liver chimera reconstitution; flow cytometry; Nippostrongylus brasiliensis infection model The Journal of experimental medicine High 25964370
2016 Bcl11b expression is activated through three distinct asynchronous mechanisms during T cell commitment: an early locus 'poising' function dependent on TCF-1 and GATA-3, a stochastic-permissivity function dependent on Notch signaling, and an amplitude-control function dependent on Runx1; these inputs act in a stage-specific manner to activate Bcl11b. Single-cell live imaging with Bcl11b knock-in fluorescent reporter mice; genetic perturbations of TCF-1, GATA-3, Notch, and Runx1; clonal analysis Nature immunology High 27376470
2016 Protein kinase C (PKC)-mediated phosphorylation of BCL11B at Serine 2 negatively regulates its interaction with NuRD complexes by dampening interaction with MTA1/MTA3 and RbAp46; upon T cell activation, phospho-Ser2 BCL11B still binds IL-2 and Id2 promoters but recruits P300 instead of MTA1 to activate transcription, defining a PTM-driven repressor-to-activator switch. Co-immunoprecipitation of endogenous MTA1/MTA3; phospho-specific antibodies; ChIP at IL-2 and Id2 promoters; in vivo activation of primary human CD4+ T cells Molecular and cellular biology High 27161321
2016 Bcl11b promotes mammary epithelial stem cell quiescence; gain- and loss-of-function studies show that Bcl11b induces cells to enter G0, and loss of Bcl11b leads to Cdkn2a-dependent exhaustion of ductal epithelium and loss of regenerative capacity. Conditional knockout mice; transplantation assays; gain-of-function overexpression; cell cycle analysis (G0 determination); genetic interaction with Cdkn2a Cell stem cell Medium 28041896
2018 Bcl11b recruits distinct cofactors to selective target sites in pro-T cells; proteomics identified multiple Bcl11b-associated cofactors, Runx1 collaborates most frequently for both activation and repression, and Bcl11b directly represses Id2 and Zbtb16, which in turn control alternative innate lymphoid and NK/NKT cell programs. Proteomics (affinity purification-MS); ChIP-seq; stage-specific in vivo and in vitro deletions; RNA-seq; cofactor deletion epistasis Nature immunology High 30374131
2018 Bcl11b binds GATA3 through protein-protein interaction, and they co-localize at Th2 cis-regulatory elements. The GATA3/Bcl11b complex limits Th2 gene expression (IL-4, IL-5, IL-13), and Bcl11b upregulation of these cytokines in Bcl11b-deficient cells is completely GATA3-dependent. Co-immunoprecipitation; ChIP-seq; RNA-seq; Bcl11b conditional KO in Th2 cells; GATA3-dependence genetic rescue The Journal of experimental medicine High 29514917
2018 BCL11B homodimerizes via its N-terminal CCHC zinc finger motif; this CCHC ZF is necessary and sufficient for dimer formation, and mutation of the CCHC ZF abolishes BCL11B transcription-regulatory activity, its ability to induce cell cycle arrest, and its protection against DNA-damage-driven apoptosis. FACS-FRET assay; affinity purification followed by mass spectrometry; deletion/point mutagenesis; cell cycle and apoptosis assays Molecular and cellular biology High 29203643
2018 Bcl11b is required for maintaining chromatin accessibility at Th2-cytokine promoters and locus-control regions, binds the Il4 HS IV silencer to reduce its accessibility, binds Gata3-intronic and downstream non-coding sites to sustain Gata3 expression, and binds upstream enhancers at the Runx3 locus to deactivate them, thereby restricting Runx3 expression in Th2 cells. ChIP-seq; ATAC-seq; conditional Bcl11b KO in mature T cells; helminth infection and allergic asthma models Nature communications High 29700302
2019 HIV-1 Vpr mediates proteasomal degradation of CTIP2 in microglial cells and CD4+ T cells via association with the Cul4A-DDB1-DCAF1 ubiquitin ligase complex; this Vpr-dependent depletion of CTIP2 at the latent HIV-1 promoter counteracts CTIP2-mediated viral gene silencing and reactivates HIV-1 expression. Co-immunoprecipitation with Cul4A-DDB1-DCAF1 complex; proteasome inhibitor rescue; ChIP at HIV-1 promoter; microglial HIV-1 latency model Scientific reports Medium 31511615
2020 Bcl11b binding to genomic regions shows distinct cell-type-specific motif preferences and occupies functionally different sites in pro-T cells versus ILC2s, controlling totally different sets of target genes. In pro-T cells, Bcl11b represses Id2 preventing innate fates; in ILC2s, Bcl11b co-expresses with Id2 and does not repress it. Additionally, Bcl11b bears cell-type-specific post-translational modifications and organizes different cell-type-specific protein complexes. ChIP-seq comparing pro-T cells and ILC2s; proteomics; conditional cell-type-specific KO; gene expression analysis The Journal of experimental medicine High 31653691
2012 Ctip2 directly and positively regulates EGFR transcription in proliferating keratinocytes and Notch1 transcription in differentiating keratinocytes, integrating proliferation/differentiation switching; EGFR activation downregulates Ctip2 at the transcript level, while high calcium signaling triggers SUMOylation, ubiquitination, and proteasomal degradation of Ctip2 protein. ChIP at EGFR and Notch1 promoters; reporter assays; calcium treatment; SUMOylation/ubiquitination assays; proteasome inhibitor experiments Journal of cell science Medium 23015591
2015 Bcl11b regulates Wnt/β-catenin target gene expression; introduction of BCL11B in human cell lines downregulated transcription of β-catenin target genes, and Bcl11b attenuation in intestinal Lgr5+ crypt base columnar cells increased expression of β-catenin targets c-Myc and cyclin D1, linking BCL11B to intestinal tumorigenesis suppression. BCL11B overexpression in human cell lines; luciferase reporter assays for β-catenin targets; Lgr5-specific conditional KO mice; Apc(min/+) tumor model Carcinogenesis Medium 25827435
2016 HIC1 physically interacts with both Bcl11b/CTIP2 and HMGA1 to co-regulate HIV-1 gene expression; HIC1 represses Tat-dependent HIV-1 transcription, this repression is linked to HIC1 K314 acetylation status and SIRT1 deacetylase activity, and HIC1 repression of Tat function occurs in a TAR-dependent manner. Co-immunoprecipitation; reporter assays; siRNA knockdown; acetylation assays; SIRT1 inhibitor treatment Scientific reports Medium 27725726
2016 Bcl11b is required for BCL11B-dependent repression of Thpok prior to the pre-selection stage of thymocyte development; this initial Thpok repression is independent of the known Thpok silencer and requires the last zinc-finger motif of Bcl11b, which is dispensable for T-lineage commitment, thus mechanistically separating priming of lineage-specifying genes from commitment. Conditional Bcl11b KO mice; zinc-finger domain deletion mutants; gene expression analysis of Thpok and Runx3; lineage scrambling analysis Nature communications Medium 28951542
2019 Bcl11b controls odorant receptor class choice in olfactory sensory neurons; loss of Bcl11b causes neurons to adopt class I OR fate by default, while gain-of-function shows Bcl11b dictates class II OR choice by suppressing the activity of the J-element, a class I-OR enhancer, revealing a binary transcriptional switch mechanism. Conditional Bcl11b KO and gain-of-function mice; in situ hybridization for OR class expression; behavioral olfaction assays Communications biology Medium 31396576
2019 Bcl11b directly binds genomic regulatory regions of Treg program genes, overlapping with Foxp3 binding, and controls their chromatin accessibility; Bcl11b-deficient Treg cells show decreased expression of essential Treg program genes and gain myeloid and NK cell programs, demonstrating Bcl11b restrains innate lineage programs in Treg cells. Treg-specific conditional KO mice; ChIP-seq; ATAC-seq; gene expression analysis; autoimmunity phenotypic assay Science advances High 31457080
2021 BCL11B regulates NK cell differentiation; Bcl11b represses RUNX2 in canonical NK cells and ZBTB16 in adaptive NK cells; ectopic Bcl11b expression drives NK cell differentiation, and Bcl11b is required for adaptive NK cell responses in a murine cytomegalovirus model. Transcriptomics and epigenomics of seven human NK cell populations; ectopic Bcl11b expression; BCL11B-mutated patient analysis; MCMV infection model Science immunology Medium 33712472
2023 BCL11B and the NuRD complex physically associate and cooperatively repress NK-cell fate in T cells; deletion of NuRD subunits (MTA2, MBD2, CHD4) or BCL11B reprograms T cells into NK-like cells (ITNKs) that upregulate OPA1, exhibit elongated mitochondria with augmented OXPHOS, and elevated acetyl-CoA that drives H3K27 acetylation at specific targets. Co-immunoprecipitation of BCL11B with NuRD; genetic deletion of NuRD subunits and BCL11B in human T cells; metabolic profiling (OXPHOS); ChIP for H3K27ac; functional antitumor assays The EMBO journal High 37737560
2024 Bcl11b directly regulates C1ql2, a synaptic organizer that controls synaptic vesicle recruitment and LTP at mossy fiber-CA3 synapses; C1ql2 exerts its function through direct interaction with the specific splice variant Nrxn3(25b+), and interruption of C1ql2-Nrxn3(25b+) interaction or deletion of Nrxn3 in dentate gyrus granule neurons recapitulates Bcl11b and C1ql2 mutant synaptic phenotypes. ChIP for direct Bcl11b target; conditional KO mice; electrophysiology (LTP at mossy fiber-CA3); Co-IP of C1ql2-Nrxn3(25b+); non-binding C1ql2 mutant rescue; synaptic vesicle analysis eLife High 38358390
2024 BCL11B succeeds PU.1 in a 'relay' mechanism to maintain mSWI/SNF chromatin remodeling complex occupancy together with RUNX1 at T effector loci after PU.1 silencing during lineage commitment, thereby poising the T cell effector chromatin landscape before TCR expression. ATAC-seq; ChIP-seq for BCL11B, RUNX1, PU.1, mSWI/SNF components; conditional KO at defined developmental stages; chromatin accessibility profiling Nature immunology High 38632339
2019 CTIP2 governs PKA signaling in human medium spiny neurons; transcriptomic analysis of CTIP2-deficient MSNs identifies CTIP2 target genes at the heart of cAMP-Ca2+ signal integration, and CTIP2 deficiency causes substantial reduction in phosphorylation of DARPP32 and GLUR1, two PKA targets. This CTIP2-dependent dysregulation is shared by Huntington's disease hPSC-derived MSNs and HD mouse model striatal tissues. Transcriptomics of CTIP2-deficient human iPSC-derived MSNs; phosphorylation analysis of DARPP32 and GLUR1; HD mouse model validation Stem cell reports Medium 31447328
2012 BCL11B regulates FGF, TGFβ superfamily, Sprouty, and Sonic hedgehog pathway gene networks to control epithelial proliferation and developmental asymmetry of the mouse incisor; BCL11B is necessary for proliferation of the labial epithelium and suppresses epithelial proliferation on the lingual side, establishing bidirectional context-dependent transcriptional control. Bcl11b conditional KO mice (incisor-specific); ChIP; gene expression analysis of FGF/TGFβ/Shh target genes PloS one Medium 22629441
2015 Bcl11b-deficient craniofacial skeleton shows increased proliferation of osteoprogenitors, premature osteoblast differentiation, and enhanced skull mineralization leading to craniosynostosis; ectopic expression of Fgfr2c and Runx2 is detected in affected sutures of Bcl11b-/- mice, suggesting BCL11B normally represses Fgfr2c in sutural mesenchyme to prevent the RUNX2-dependent osteogenic program. Bcl11b knockout mice; histology; immunohistochemistry for FGFR2c and RUNX2; gene expression analysis Developmental biology Medium 26453795
2016 BCL11B regulates adipogenesis by stimulating C/EBPβ transcriptional activity and suppressing the Wnt/β-catenin signaling pathway; BCL11B expression transiently increases during adipogenesis, BCL11B knockdown reduces adipogenic capacity in 3T3-L1 cells and MEFs, and BCL11B-/- MEFs show failure to suppress Wnt/β-catenin target genes during differentiation. BCL11B knockout MEFs; 3T3-L1 knockdown; luciferase reporter assays for C/EBPβ activity and β-catenin targets; gene expression analysis Scientific reports Medium 27586877
2012 Ctip2 controls epidermal lipid metabolism; Ctip2-/- mice display altered ceramide and sphingomyelin composition, and Ctip2 is recruited to the promoter regions of genes involved in skin sphingolipid biosynthesis, suggesting direct transcriptional regulation of these genes. Ctip2 knockout mice; targeted lipidomics by mass spectrometry; ChIP at sphingolipid gene promoters The Journal of investigative dermatology Medium 23096701
2023 Bcl11b sustains the multipotent/multifunctional transcriptional program of intestinal-resident memory CD8+ T cells by maintaining chromatin accessibility and activating histone marks at TCF7 and other MP/MF program loci, while restricting the effector program (Prdm1/Blimp1) and limiting Ahr expression; Bcl11b acts upstream of Tcf1 and Blimp1 in the tissue residency program. Post-activation conditional Bcl11b KO in CD8+ T cells; ATAC-seq; ChIP for histone marks; Listeria infection model; recall response assays Science immunology High 37115913

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2003 Bcl11b is required for differentiation and survival of alphabeta T lymphocytes. Nature immunology 300 12717433
2007 Recruitment of chromatin-modifying enzymes by CTIP2 promotes HIV-1 transcriptional silencing. The EMBO journal 297 17245431
2008 The Fezf2-Ctip2 genetic pathway regulates the fate choice of subcortical projection neurons in the developing cerebral cortex. Proceedings of the National Academy of Sciences of the United States of America 279 18678899
2008 Ctip2 controls the differentiation of medium spiny neurons and the establishment of the cellular architecture of the striatum. The Journal of neuroscience : the official journal of the Society for Neuroscience 264 18199763
2021 Enhancer Hijacking Drives Oncogenic BCL11B Expression in Lineage-Ambiguous Stem Cell Leukemia. Cancer discovery 159 34103329
2015 Transcription Factor Bcl11b Controls Identity and Function of Mature Type 2 Innate Lymphoid Cells. Immunity 146 26231117
2015 Bcl11b is essential for group 2 innate lymphoid cell development. The Journal of experimental medicine 139 25964370
2004 CTIP1 and CTIP2 are differentially expressed during mouse embryogenesis. Gene expression patterns : GEP 132 15465497
2007 BCL11B is required for positive selection and survival of double-positive thymocytes. The Journal of experimental medicine 117 17998389
2016 Asynchronous combinatorial action of four regulatory factors activates Bcl11b for T cell commitment. Nature immunology 114 27376470
2013 A far downstream enhancer for murine Bcl11b controls its T-cell specific expression. Blood 105 23741008
2003 Homozygous deletions and point mutations of the Rit1/Bcl11b gene in gamma-ray induced mouse thymic lymphomas. Biochemical and biophysical research communications 104 12565905
2009 p21(WAF1) gene promoter is epigenetically silenced by CTIP2 and SUV39H1. Oncogene 101 19581932
2012 A dual function of Bcl11b/Ctip2 in hippocampal neurogenesis. The EMBO journal 99 22588081
2018 Bcl11b sets pro-T cell fate by site-specific cofactor recruitment and by repressing Id2 and Zbtb16. Nature immunology 97 30374131
2005 Disruption of the BCL11B gene through inv(14)(q11.2q32.31) results in the expression of BCL11B-TRDC fusion transcripts and is associated with the absence of wild-type BCL11B transcripts in T-ALL. Leukemia 97 15668700
2010 Critical roles of Bcl11b in T-cell development and maintenance of T-cell identity. Immunological reviews 94 20969590
2016 A Quiescent Bcl11b High Stem Cell Population Is Required for Maintenance of the Mammary Gland. Cell stem cell 92 28041896
2006 CTIP2 associates with the NuRD complex on the promoter of p57KIP2, a newly identified CTIP2 target gene. The Journal of biological chemistry 86 16950772
2014 The multifaceted roles of Bcl11b in thymic and peripheral T cells: impact on immune diseases. Journal of immunology (Baltimore, Md. : 1950) 78 25128552
2013 CTIP2 is a negative regulator of P-TEFb. Proceedings of the National Academy of Sciences of the United States of America 75 23852730
2021 14q32 rearrangements deregulating BCL11B mark a distinct subgroup of T-lymphoid and myeloid immature acute leukemia. Blood 74 33876209
2021 The transcription factor Bcl11b promotes both canonical and adaptive NK cell differentiation. Science immunology 73 33712472
2011 Common genetic variation in the 3'-BCL11B gene desert is associated with carotid-femoral pulse wave velocity and excess cardiovascular disease risk: the AortaGen Consortium. Circulation. Cardiovascular genetics 73 22068335
2017 Bcl11b and combinatorial resolution of cell fate in the T-cell gene regulatory network. Proceedings of the National Academy of Sciences of the United States of America 72 28584128
2012 The CB(1) cannabinoid receptor drives corticospinal motor neuron differentiation through the Ctip2/Satb2 transcriptional regulation axis. The Journal of neuroscience : the official journal of the Society for Neuroscience 69 23175820
2006 Inhibition of BCL11B expression leads to apoptosis of malignant but not normal mature T cells. Oncogene 68 17173069
2011 LSD1 cooperates with CTIP2 to promote HIV-1 transcriptional silencing. Nucleic acids research 67 22067449
2003 Recruitment of Tat to heterochromatin protein HP1 via interaction with CTIP2 inhibits human immunodeficiency virus type 1 replication in microglial cells. Journal of virology 65 12692243
2017 Bcl11b-A Critical Neurodevelopmental Transcription Factor-Roles in Health and Disease. Frontiers in cellular neuroscience 60 28424591
2014 Unc5C and DCC act downstream of Ctip2 and Satb2 and contribute to corpus callosum formation. Nature communications 59 24739528
2020 Cell type-specific actions of Bcl11b in early T-lineage and group 2 innate lymphoid cells. The Journal of experimental medicine 57 31653691
2012 Role of the transcription factor Bcl11b in development and lymphomagenesis. Proceedings of the Japan Academy. Series B, Physical and biological sciences 56 22450536
2011 Bcl11b/Ctip2 controls the differentiation of vomeronasal sensory neurons in mice. The Journal of neuroscience : the official journal of the Society for Neuroscience 54 21752992
2009 Ctip2/Bcl11b controls ameloblast formation during mammalian odontogenesis. Proceedings of the National Academy of Sciences of the United States of America 54 19251658
2017 The T-ALL related gene BCL11B regulates the initial stages of human T-cell differentiation. Leukemia 52 28232744
2012 Delayed cutaneous wound healing and aberrant expression of hair follicle stem cell markers in mice selectively lacking Ctip2 in epidermis. PloS one 51 22383956
2017 Priming of lineage-specifying genes by Bcl11b is required for lineage choice in post-selection thymocytes. Nature communications 50 28951542
2014 HMGA1 recruits CTIP2-repressed P-TEFb to the HIV-1 and cellular target promoters. Nucleic acids research 47 24623795
2007 Haploinsufficiency of Bcl11b for suppression of lymphomagenesis and thymocyte development. Biochemical and biophysical research communications 47 17306224
2018 Bcl11b, a novel GATA3-interacting protein, suppresses Th1 while limiting Th2 cell differentiation. The Journal of experimental medicine 46 29514917
2003 Activation of HOX11L2 by juxtaposition with 3'-BCL11B in an acute lymphoblastic leukemia cell line (HPB-ALL) with t(5;14)(q35;q32.2). Genes, chromosomes & cancer 46 12661009
2010 The corticofugal neuron-associated genes ROBO1, SRGAP1, and CTIP2 exhibit an anterior to posterior gradient of expression in early fetal human neocortex development. Cerebral cortex (New York, N.Y. : 1991) 44 21060114
2022 Single-cell deletion analyses show control of pro-T cell developmental speed and pathways by Tcf7, Spi1, Gata3, Bcl11a, Erg, and Bcl11b. Science immunology 42 35594339
2017 Promoter hypermethylation of BCL11B gene correlates with downregulation of gene transcription in ankylosing spondylitis patients. Genes and immunity 42 28794504
2013 BCL11B is up-regulated by EWS/FLI and contributes to the transformed phenotype in Ewing sarcoma. PloS one 38 23527175
2012 Selective ablation of Ctip2/Bcl11b in epidermal keratinocytes triggers atopic dermatitis-like skin inflammatory responses in adult mice. PloS one 36 23284675
2018 Bcl11b is essential for licensing Th2 differentiation during helminth infection and allergic asthma. Nature communications 33 29700302
2020 Distinct Notch1 and BCL11B requirements mediate human γδ/αβ T cell development. EMBO reports 32 32255245
2016 Structure-function integrity of the adult hippocampus depends on the transcription factor Bcl11b/Ctip2. Genes, brain, and behavior 32 26915960
2012 Ctip2 is a dynamic regulator of epidermal proliferation and differentiation by integrating EGFR and Notch signaling. Journal of cell science 32 23015591
2019 Bcl11b controls odorant receptor class choice in mice. Communications biology 31 31396576
2007 Expression of COUP-TF-interacting protein 2 (CTIP2) in mouse skin during development and in adulthood. Gene expression patterns : GEP 31 17631058
2019 Bcl11b prevents fatal autoimmunity by promoting Treg cell program and constraining innate lineages in Treg cells. Science advances 29 31457080
2016 Protein Kinase C-Mediated Phosphorylation of BCL11B at Serine 2 Negatively Regulates Its Interaction with NuRD Complexes during CD4+ T-Cell Activation. Molecular and cellular biology 29 27161321
2011 Down regulation of BCL11B expression inhibits proliferation and induces apoptosis in malignant T cells by BCL11B-935-siRNA. Hematology (Amsterdam, Netherlands) 29 21756541
2021 Inhibition of BCL11B induces downregulation of PTK7 and results in growth retardation and apoptosis in T-cell acute lymphoblastic leukemia. Biomarker research 28 33663588
2019 HIV-1 Vpr mediates the depletion of the cellular repressor CTIP2 to counteract viral gene silencing. Scientific reports 28 31511615
2018 The N-Terminal CCHC Zinc Finger Motif Mediates Homodimerization of Transcription Factor BCL11B. Molecular and cellular biology 28 29203643
2022 Transcription factors Bcl11a and Bcl11b are required for the production and differentiation of cortical projection neurons. Cerebral cortex (New York, N.Y. : 1991) 27 34963132
2009 CTIP2 expression in human head and neck squamous cell carcinoma is linked to poorly differentiated tumor status. PloS one 27 19399189
2022 Comparative roadmaps of reprogramming and oncogenic transformation identify Bcl11b and Atoh8 as broad regulators of cellular plasticity. Nature cell biology 26 36075976
2016 HIC1 controls cellular- and HIV-1- gene transcription via interactions with CTIP2 and HMGA1. Scientific reports 26 27725726
2015 BCL11B/CTIP2 is highly expressed in GABAergic interneurons of the mouse somatosensory cortex. Journal of chemical neuroanatomy 26 26698402
2012 BCL11B regulates epithelial proliferation and asymmetric development of the mouse mandibular incisor. PloS one 26 22629441
2010 Analysis of the expression pattern of the BCL11B gene and its relatives in patients with T-cell acute lymphoblastic leukemia. Journal of hematology & oncology 26 21080944
2020 Mutant BCL11B in a Patient With a Neurodevelopmental Disorder and T-Cell Abnormalities. Frontiers in pediatrics 25 33194885
2017 Gga-miR-219b targeting BCL11B suppresses proliferation, migration and invasion of Marek's disease tumor cell MSB1. Scientific reports 25 28652615
2010 Increased expression of bcl11b leads to chemoresistance accompanied by G1 accumulation. PloS one 25 20824091
2021 Epigenetic Dynamics in the Function of T-Lineage Regulatory Factor Bcl11b. Frontiers in immunology 24 33936112
2012 Transcription factor Ctip2 controls epidermal lipid metabolism and regulates expression of genes involved in sphingolipid biosynthesis during skin development. The Journal of investigative dermatology 24 23096701
2020 miR-21-5p promotes cell proliferation by targeting BCL11B in Thp-1 cells. Oncology letters 23 33376550
2019 CTIP2-Regulated Reduction in PKA-Dependent DARPP32 Phosphorylation in Human Medium Spiny Neurons: Implications for Huntington Disease. Stem cell reports 23 31447328
2018 Downregulated miR-17, miR-29c, miR-92a and miR-214 may be related to BCL11B overexpression in T cell acute lymphoblastic leukemia. Asia-Pacific journal of clinical oncology 23 29749698
2016 Transcription factor Bcl11b sustains iNKT1 and iNKT2 cell programs, restricts iNKT17 cell program, and governs iNKT cell survival. Proceedings of the National Academy of Sciences of the United States of America 23 27330109
2024 PU.1 and BCL11B sequentially cooperate with RUNX1 to anchor mSWI/SNF to poise the T cell effector landscape. Nature immunology 22 38632339
2014 Low expression of T-cell transcription factor BCL11b predicts inferior survival in adult standard risk T-cell acute lymphoblastic leukemia patients. Journal of hematology & oncology 22 25023966
2015 Bcl11b SWI/SNF-complex subunit modulates intestinal adenoma and regeneration after γ-irradiation through Wnt/β-catenin pathway. Carcinogenesis 21 25827435
2013 Reduced level of the BCL11B protein is associated with adult T-cell leukemia/lymphoma. PloS one 20 23383087
2021 Redefining the biological basis of lineage-ambiguous leukemia through genomics: BCL11B deregulation in acute leukemias of ambiguous lineage. Best practice & research. Clinical haematology 19 34865701
2020 Bcl11b/Ctip2 in Skin, Tooth, and Craniofacial System. Frontiers in cell and developmental biology 19 33363142
2019 Chimeric antigen receptor-induced BCL11B suppression propagates NK-like cell development. The Journal of clinical investigation 19 31479431
2016 Transcription Factor Bcl11b Controls Effector and Memory CD8 T cell Fate Decision and Function during Poxvirus Infection. Frontiers in immunology 19 27790219
2015 BCL11B regulates sutural patency in the mouse craniofacial skeleton. Developmental biology 19 26453795
2020 High Specificity of BCL11B and GLG1 for EWSR1-FLI1 and EWSR1-ERG Positive Ewing Sarcoma. Cancers 18 32164354
2020 BCL11B suppresses tumor progression and stem cell traits in hepatocellular carcinoma by restoring p53 signaling activity. Cell death & disease 18 33093445
2018 Bcl11b Regulates IL-17 Through the TGF-β/Smad Pathway in HDM-Induced Asthma. Allergy, asthma & immunology research 18 30088373
2016 N-acetylcysteine attenuates lipopolysaccharide-induced impairment in lamination of Ctip2-and Tbr1- expressing cortical neurons in the developing rat fetal brain. Scientific reports 18 27577752
2016 Identification of BCL11B as a regulator of adipogenesis. Scientific reports 17 27586877
2014 Bcl11b prevents the intrathymic development of innate CD8 T cells in a cell intrinsic manner. International immunology 17 25422283
2012 The role of BCL11B in regulating the proliferation of human naive T cells. Human immunology 17 22426257
2012 BCL11B, FLT3, NOTCH1 and FBXW7 mutation status in T-cell acute lymphoblastic leukemia patients. Blood cells, molecules & diseases 17 23040356
2024 Regulation of hippocampal mossy fiber-CA3 synapse function by a Bcl11b/C1ql2/Nrxn3(25b+) pathway. eLife 16 38358390
2023 Bcl11b sustains multipotency and restricts effector programs of intestinal-resident memory CD8+ T cells. Science immunology 16 37115913
2023 BCL11B and the NuRD complex cooperatively guard T-cell fate and inhibit OPA1-mediated mitochondrial fusion in T cells. The EMBO journal 16 37737560
2017 BCL11B-Mediated Epigenetic Repression Is a Crucial Target for Histone Deacetylase Inhibitors in Cutaneous T-Cell Lymphoma. The Journal of investigative dermatology 16 28288848
2014 TNF-α-dependent hematopoiesis following Bcl11b deletion in T cells restricts metastatic melanoma. Journal of immunology (Baltimore, Md. : 1950) 16 24446520
2013 Aberrant expression of BCL11B in mycosis fungoides and its potential role in interferon-induced apoptosis. The Journal of dermatology 15 23682716
2015 Bcl11b: A New Piece to the Complex Puzzle of Amyotrophic Lateral Sclerosis Neuropathogenesis? Neurotoxicity research 14 26563995
2014 BCL11B expression in intramembranous osteogenesis during murine craniofacial suture development. Gene expression patterns : GEP 14 25511173

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