Affinage

SUV39H1

Histone-lysine N-methyltransferase SUV39H1 · UniProt O43463

Length
412 aa
Mass
47.9 kDa
Annotated
2026-06-10
100 papers in source corpus 37 papers cited in narrative 37 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 9/9 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

SUV39H1 is a SET-domain histone methyltransferase that establishes constitutive heterochromatin by trimethylating histone H3 at lysine 9 (H3K9me3) at pericentric regions, an activity required to protect genome stability and ensure faithful chromosome segregation (PMID:11701123, PMID:10779362). Its substrate engagement depends on recognition of H3 residues flanking K9, with strict readout of R8 (PMID:28169523). Stable tethering to heterochromatin is achieved through two complementary modules: the SET domain mediates structural, near-immobile binding to pericentric chromatin, while the chromodomain recognizes both pre-existing H3K9me3 and chromatin-associated RNA, including major satellite/α-satellite transcripts that retain the enzyme in cis (PMID:16103223, PMID:26807716, PMID:28760200, PMID:28760201). Chromodomain-based H3K9me3 reading also drives a two-step allosteric activation switch, anchoring the enzyme and stimulating catalysis to spread H3K9me2/3 by positive feedback (PMID:26807716). SUV39H1-deposited H3K9me3 in turn directs Dnmt3b-dependent DNA methylation to pericentric satellite repeats and silences intact LINE/ERV retrotransposons in ES cells, with the histone and DNA methylation machineries physically bridged through direct interactions with DNMT3a, DNMT1, and HP1 proteins (PMID:12867029, PMID:12711675, PMID:24981170). SUV39H1 functions within a larger H3K9 methyltransferase network (G9a, GLP, SETDB1) whose members are mutually stabilized and co-recruited to satellite repeats (PMID:20129054), and it cooperates with HP1 both by binding via its N-terminal residues and by promoting HP1α sumoylation to seed de novo HP1 targeting (PMID:12565857, PMID:27426629, PMID:23836914). Beyond bulk heterochromatin, it is recruited by sequence-specific transcription factors—including the Rb/E2F axis in differentiating myoblasts, MyoD, AP-2α, and Snail—to deposit repressive H3K9me3 at defined promoters governing cell differentiation, EMT, and metastasis (PMID:14765126, PMID:16858404, PMID:22562246, PMID:24732798). Its activity is tightly controlled by post-translational modification: SIRT1-mediated deacetylation at K266 activates the enzyme and stabilizes it by blocking MDM2-dependent K87 polyubiquitination, SET7/9-mediated methylation at K105/K123 inhibits it, CDK2 phosphorylation at S391 releases it from chromatin during S phase, and conserved automethylation autoinhibits catalysis (PMID:18004385, PMID:21504832, PMID:23509280, PMID:24728993, PMID:30051891). SUV39H1 additionally methylates non-histone substrates such as SET8, RAG2, and DOT1L (PMID:28169523).

Mechanistic history

Synthesis pass · year-by-year structured walk · 32 steps
  1. 2000 High

    Established that SUV39H1 dynamically localizes to centromeres during mitosis and that its two ends carry separable functions, framing a model in which an N-terminal targeting region and a C-terminal catalytic domain coordinate heterochromatin function.

    Evidence Cell-cycle fractionation, immunofluorescence on dicentric/neocentromere chromosomes, and structure-function analysis with truncation mutants in transfected cells

    PMID:10671371 PMID:10779362

    Open questions at the time
    • Did not establish the enzymatic mark deposited in vivo
    • Phosphorylation sites and responsible kinases unmapped
  2. 2001 High

    Demonstrated genetically that Suv39h enzymes deposit pericentric H3K9 trimethylation and that this mark is essential for genome stability, defining the core biological role.

    Evidence Suv39h double-knockout mice with chromosome instability, tumor risk, and meiotic defects

    PMID:11701123

    Open questions at the time
    • Mechanism of recruitment to pericentric chromatin not resolved
    • Downstream effectors of instability undefined
  3. 2003 High

    Showed that SUV39H1-dependent H3K9me3 acts upstream of DNA methylation by recruiting Dnmt3b, and physically connected the histone and DNA methylation machineries via HP1 and DNMT interactions.

    Evidence Genetic epistasis in Suv39h-null ES cells, bisulfite sequencing, co-IP and GST pulldown with Dnmt3a/Dnmt1/HP1β

    PMID:12711675 PMID:12867029

    Open questions at the time
    • Stoichiometry and ordering of the histone-DNA methyltransferase complex unresolved
    • Whether interactions occur simultaneously in one complex untested
  4. 2002 Medium

    Linked SUV39H1 to deacetylase-dependent transcriptional repression, identifying an N-terminal repression domain functioning independently of catalysis.

    Evidence Co-IP with HDAC1/2/3 and reporter repression assays sensitive to HDAC inhibition

    PMID:11788710

    Open questions at the time
    • Single lab, two methods
    • Genomic targets of the HDAC-coupled repression not mapped
  5. 2004 Medium

    Defined a context-specific recruitment mode in which Suv39h methylates Rb/E2F target promoters selectively in differentiating cells, coupling heterochromatin machinery to cell-fate decisions.

    Evidence ChIP plus siRNA knockdown with differentiation readouts in myoblasts

    PMID:14765126

    Open questions at the time
    • Direct recruitment factor at these promoters not identified here
    • Single lab
  6. 2005 Medium

    Resolved the basis of stable heterochromatin tethering, showing the SET domain confers immobile structural binding largely independent of HP1.

    Evidence FRAP and FRET with deletion mutants in living cells

    PMID:16103223

    Open questions at the time
    • Molecular partner mediating SET-dependent anchoring not identified
    • Transient versus stable HP1 contributions only qualitatively defined
  7. 2006 Medium

    Extended factor-directed recruitment by showing Suv39h1 binds MyoD and represses muscle gene expression through HMT activity on target chromatin.

    Evidence Co-IP, ChIP, overexpression and siRNA with reporter and differentiation assays

    PMID:16858404

    Open questions at the time
    • Single lab
    • Interplay with the Rb/E2F differentiation pathway not integrated
  8. 2007 High

    Identified SIRT1 deacetylation at K266 as a direct activating switch for SUV39H1 catalysis, establishing the first PTM control of enzyme activity.

    Evidence Co-IP, in vitro deacetylation, K266 mutagenesis, and SIRT1 loss-of-function

    PMID:18004385

    Open questions at the time
    • Acetyltransferase responsible for K266 acetylation not identified
    • Quantitative contribution to global H3K9me3 unclear
  9. 2007 Medium

    Implicated the SUV39H1/HP1γ/H3K9me3 axis in chromatin-mediated silencing of integrated HIV-1, extending heterochromatin function to viral latency.

    Evidence ChIP, siRNA, and reporter assays in cellular and primary HIV-1 models

    PMID:17245432

    Open questions at the time
    • Direct SUV39H1 knockdown reactivation not demonstrated
    • Single lab
  10. 2010 Medium

    Placed SUV39H1 within a co-dependent megacomplex of H3K9 methyltransferases that are mutually stabilized and co-recruited to satellite and gene targets.

    Evidence Co-IP, protein stability in null cells, and ChIP

    PMID:20129054

    Open questions at the time
    • Architecture and direct contacts within the megacomplex unresolved
    • Single lab
  11. 2011 High

    Showed SIRT1 controls SUV39H1 abundance by blocking MDM2-dependent K87 polyubiquitination, linking enzyme stability to nutrient state.

    Evidence Ubiquitination and stability assays, K87 mutagenesis, and an in vivo calorie restriction model

    PMID:21504832

    Open questions at the time
    • How SIRT1 inhibits MDM2 toward this substrate not detailed
    • Other E3 contributions not excluded
  12. 2012 Medium

    Demonstrated that SUV39H1 methylation dynamics at the centromere are required for proper kinetochore-microtubule attachment and chromosome congression, mechanistically connecting H3K9 methylation to error-free segregation.

    Evidence Centromere-targeted FRET methylation sensors and chaetocin inhibition in living HeLa cells

    PMID:22831836

    Open questions at the time
    • Pharmacological inhibitor specificity limits attribution
    • Link to Aurora B/MCAK pathway correlative
  13. 2012 Medium

    Identified Snail as a recruiter of SUV39H1 to the E-cadherin promoter, defining an EMT/metastasis-promoting repression mechanism via SET-SNAG domain interaction.

    Evidence Co-IP with domain mapping, ChIP, knockdown, and in vivo metastasis assays in breast cancer cells

    PMID:22562246

    Open questions at the time
    • Single lab
    • Generality across other EMT transcription factors untested here
  14. 2013 High

    Discovered SET7/9-mediated methylation of SUV39H1 at K105/K123 as an inhibitory PTM that relaxes heterochromatin under DNA damage, adding a counterbalancing control to SIRT1 activation.

    Evidence Co-IP, mass spectrometry, methylation-specific antibodies, in vitro MTase and MNase sensitivity assays

    PMID:23509280

    Open questions at the time
    • Physiological signals beyond adriamycin not defined
    • Crosstalk with K266 acetylation not integrated
  15. 2013 High

    Showed that A-type lamins (and progerin) stabilize SUV39H1, and that Suv39h1 depletion delays senescence and extends lifespan in progeroid mice, tying heterochromatin maintenance to aging.

    Evidence Co-IP, stability assays, genetic depletion with DNA repair, senescence and Zmpste24-/- lifespan readouts

    PMID:23695662

    Open questions at the time
    • Mechanism by which lamin binding blocks degradation not detailed
    • Relationship to MDM2/CRL4 pathways unresolved
  16. 2013 Medium

    Established CRL4B/H2AK119ub as an upstream facilitator of SUV39H1-dependent H3K9me3 and DNA methylation, adding a ubiquitin-dependent chromatin crosstalk layer.

    Evidence Co-IP with SUV39H1/HP1/DNMT3A, ChIP, knockdown, and ubiquitination assays

    PMID:24292684

    Open questions at the time
    • Direct versus indirect facilitation not separated
    • Single lab
  17. 2013 Medium

    Dissected the HP1-binding contribution by showing direct Suv39h-HP1 binding is dispensable for pericentric H3K9me3/DNA methylation but needed for full HP1 recruitment and complete heterochromatin features.

    Evidence Reconstitution of ΔN truncation mutants in Suv39h-null ES cells with IF, ChIP and bisulfite sequencing

    PMID:23836914

    Open questions at the time
    • Alternative HP1-independent targeting determinant not identified here
    • Single lab
  18. 2014 High

    Identified CDK2 phosphorylation at S391 as a cell-cycle switch that evicts Suv39h1 from chromatin in S phase, allowing demethylase access and altered replication timing.

    Evidence In vitro kinase assay, phospho-specific antibodies, synchronized chromatin fractionation, and phospho-mimic mutants

    PMID:24728993

    Open questions at the time
    • Phosphatase reversing S391 not identified
    • Coordination with other PTMs across the cycle unmapped
  19. 2014 High

    Mapped the Suv39h-dependent H3K9me3 landscape genome-wide, showing selective silencing of intact LINE/ERV retrotransposons in ES cells.

    Evidence Genome-wide ChIP-seq in Suv39h double-null versus wild-type ES cells with repeat subfamily analysis

    PMID:24981170

    Open questions at the time
    • Determinants of selectivity for intact elements unresolved
    • Handoff to DNA methylation in committed cells only inferred
  20. 2014 Medium

    Extended factor-directed repression to adipogenesis, showing Suv39h1 cooperates with AP-2α and G9a in a sequential H3K9me2-to-me3 pathway at the C/EBPα promoter.

    Evidence Co-IP, ChIP, knockdown and overexpression with differentiation assays

    PMID:24732798

    Open questions at the time
    • Single lab
    • Ordering of AP-2α versus G9a recruitment correlative
  21. 2016 High

    Defined the two-step allosteric activation mechanism whereby chromodomain reading of H3K9me3 anchors the enzyme and stimulates catalysis to drive feedback spreading of the mark.

    Evidence Semi-synthetic designer chromatin reconstitution, in vitro MTase assays, chromodomain mutagenesis, cellular validation

    PMID:26807716

    Open questions at the time
    • How spreading is bounded at heterochromatin borders unresolved
    • Integration with RNA-binding by the same domain not addressed here
  22. 2016 Medium

    Revealed a catalysis-independent function in which Suv39h1 binds Ubc9 to promote HP1α sumoylation and seed de novo HP1 targeting.

    Evidence In vitro sumoylation, co-IP, heterochromatin tethering, and Ubc9-binding mutants

    PMID:27426629

    Open questions at the time
    • Single lab
    • Relative contribution versus H3K9me3-driven HP1 recruitment unclear
  23. 2017 High

    Established that chromatin-associated RNA, including α-satellite/major satellite transcripts, binds the chromodomain to retain SUV39H1 at heterochromatin, defining an RNA-dependent tethering mechanism distinct from H3K9me3 reading.

    Evidence In vitro nucleic acid binding, chromodomain mutagenesis, RNase/RNA-Pol inhibition, RNA-IP, RNA knockdown, native nucleosome purification across three studies

    PMID:28760199 PMID:28760200 PMID:28760201

    Open questions at the time
    • Whether RNA and H3K9me3 binding are mutually exclusive on the chromodomain unresolved
    • Role of RNA:DNA hybrids in human SUV39H1 vs paralog not fully separated
  24. 2017 Medium

    Showed isoform-selective HP1α/γ interactions reciprocally stabilize Suv39h1 by inhibiting MDM2-dependent K87 ubiquitination, integrating heterochromatin proteins into stress-responsive enzyme turnover.

    Evidence Co-IP, FRAP, stability and ubiquitination assays with isoform-specific knockdown

    PMID:28059589

    Open questions at the time
    • Single lab
    • Mechanism distinguishing HP1β exclusion not detailed
  25. 2017 Medium

    Defined SUV39H1 substrate-recognition rules and expanded its substrate repertoire to non-histone proteins including SET8, RAG2 and DOT1L, with functional consequences for H4K20 methylation.

    Evidence Peptide array specificity profiling, in vitro and cellular methylation, and SET8 activity assays

    PMID:28169523

    Open questions at the time
    • In vivo significance of each non-histone methylation event not fully established
    • Single lab
  26. 2017 Medium

    Implicated SUV39H/HP1γ in repressing SIRT1 transcription in stressed cardiomyocytes, revealing a feedback loop between the enzyme and its own activator and a role in myocardial injury.

    Evidence ChIP, SUV39H knockout mice, and chaetocin inhibition with cardiac function readouts

    PMID:28361889

    Open questions at the time
    • Inhibitor specificity limits attribution
    • Single lab
  27. 2017 Medium

    Showed SUV39H1 methylates the mycobacterial protein HupB to limit bacterial adhesion and survival, extending its activity to host-pathogen interaction.

    Evidence In vitro MTase assay, co-IP, adhesion and intracellular survival assays, mouse infection model

    PMID:29170282

    Open questions at the time
    • Single lab
    • Physiological relevance to human TB control not established
  28. 2018 High

    Established an evolutionarily conserved automethylation autoinhibition mechanism via crystallography of the S. pombe ortholog, with a corresponding automethylated lysine in human SUV39H2.

    Evidence X-ray crystallography, biochemical MTase assays, mutagenesis, and in vivo heterochromatin analysis in S. pombe

    PMID:30051891

    Open questions at the time
    • Direct demonstration of the autoinhibitory switch in human SUV39H1 not shown
    • Trigger relieving autoinhibition in vivo unknown
  29. 2018 Medium

    Identified SirT6-mediated cysteine monoubiquitination of the PRE-SET domain as a signal that releases Suv39h1 from the IκBα locus to attenuate NF-κB signaling.

    Evidence Co-IP, ubiquitination and ChIP assays with site-directed mutagenesis and NF-κB reporters

    PMID:29317652

    Open questions at the time
    • Single lab
    • Generality beyond the IκBα locus untested
  30. 2018 High

    Showed CRL4-DCAF13 degrades SUV39H1 to enable H3K9me3 removal and zygotic gene activation during preimplantation development, linking enzyme turnover to embryonic reprogramming.

    Evidence Co-IP, ubiquitination assays, and Dcaf13 knockout mice with embryo arrest and IF readouts

    PMID:30111536

    Open questions at the time
    • How DCAF13 selects SUV39H1 versus other substrates unclear
    • Relationship to MDM2/CRL4B degradation pathways unresolved
  31. 2024 Medium

    Identified UHRF1-deposited H3K18ub as an activating chromatin signal for SUV39H1/H2, mediating H3K9me3 accumulation at CpG island promoters and limiting the antiproliferative effect of DNMT1 inhibition.

    Evidence In vitro MTase assays on H3K18ub nucleosomes, genome-wide ChIP-seq, and UHRF1 disruption in colon cancer cells

    PMID:39631394

    Open questions at the time
    • Structural basis of H3K18ub stimulation not resolved
    • Single lab
  32. 2024 Medium

    Demonstrated that SUV39H1 disruption in CAR T cells enhances persistence and antitumor efficacy by preserving memory programs and limiting exhaustion, defining a therapeutic application.

    Evidence CRISPR editing in human CAR T cells with scRNA-seq, scATAC-seq, and in vivo rechallenge models

    PMID:37934007

    Open questions at the time
    • Direct chromatin targets driving the exhaustion program not pinpointed
    • Single lab

Open questions

Synthesis pass · forward-looking unresolved questions
  • How the multiple, sometimes opposing post-translational modifications and chromatin-derived signals are integrated to set SUV39H1 activity and abundance in a given cellular context remains unresolved.
  • No unified quantitative model linking acetylation, methylation, phosphorylation, ubiquitination and automethylation
  • Structure of human full-length SUV39H1 on a nucleosome not determined
  • Hierarchy among MDM2, CRL4B, CRL4-DCAF13 and SirT6 degradation inputs undefined

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0016740 transferase activity 5 GO:0140110 transcription regulator activity 4 GO:0003723 RNA binding 3 GO:0042393 histone binding 2 GO:0140096 catalytic activity, acting on a protein 2
Localization
GO:0000228 nuclear chromosome 4 GO:0005634 nucleus 3 GO:0005694 chromosome 3
Pathway
R-HSA-1266738 Developmental Biology 4 R-HSA-4839726 Chromatin organization 4 R-HSA-74160 Gene expression (Transcription) 4 R-HSA-1640170 Cell Cycle 3
Partners
CDK2DNMT1DNMT3AG9AHP1 (CBX5/CBX1/CBX3)MDM2SETD7SIRT1
Complex memberships
H3K9 methyltransferase megacomplex (G9a/GLP/SETDB1/Suv39h1)core HDAC complex (HDAC1/HDAC2/RbAp48/RbAp46)

Evidence

Reading pass · 37 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2001 Murine Suv39h histone methyltransferases govern H3K9 trimethylation specifically at pericentric heterochromatin; Suv39h-deficient mice display impaired viability, chromosomal instabilities, increased tumor risk, and perturbed chromosome interactions during male meiosis, establishing a crucial role for pericentric H3-K9 methylation in protecting genome stability. Suv39h double-knockout mice; immunofluorescence; chromosome analysis Cell High 11701123
2000 SUV39H1 transiently accumulates at centromeric positions during prometaphase and dissociates at the meta-to-anaphase transition; overexpression of full-length SUV39H1 induces severe mitotic defects and chromosome segregation errors and disperses the focal G2-specific distribution of phosphorylated histone H3 at serine 10; these properties depend on the C-terminal SET domain, while the N-terminal chromo domain plus first 44 amino acids direct specific accumulation at heterochromatin. The M31 (HP1β) interaction surface maps to the first 44 N-terminal amino acids. Structure-function analysis with deletion/truncation mutants in transfected cells; immunofluorescence; mitotic progression assays Molecular and cellular biology High 10779362
2000 SUV39H1 selectively associates with the active centromere of a dicentric chromosome and with neocentromeres during prometaphase, and is a phosphoprotein; two additional phosphorylated isoforms appear specifically in mitotic extracts at serine and to a lesser degree threonine residues, while steady-state protein levels remain constant during the cell cycle. Cell-cycle fractionation; immunofluorescence on dicentric/neocentromere chromosomes; phosphopeptide analysis Journal of cell science Medium 10671371
2003 Suv39h-mediated H3K9 trimethylation at pericentric heterochromatin is required to direct Dnmt3b-dependent DNA methylation to major satellite repeats; in Suv39h double-null ES cells, Dnmt3b fails to localize to heterochromatic foci and displays altered DNA methylation at pericentric satellite repeats. Conversely, H3K9 trimethylation at pericentric heterochromatin is not impaired in Dnmt-deficient ES cells. Physical interaction between Dnmt3b and HP1α is also demonstrated. Suv39h double-null mouse ES cells; immunofluorescence; bisulfite sequencing; co-immunoprecipitation Current biology : CB High 12867029
2003 SUV39H1 physically interacts with Dnmt3a (via Dnmt3a's PHD-like motif), with Dnmt1, and with HP1β both in vitro (GST pulldown) and in vivo (co-IP); SUV39H1 can purify DNA methyltransferase activity from nuclear extracts; HP1β also directly binds Dnmt1 and Dnmt3a, establishing a direct connection between the histone methylation and DNA methylation machineries. Co-immunoprecipitation (endogenous and transfected); GST pulldown; histone methyltransferase activity assay on nuclear extracts Nucleic acids research High 12711675
2002 SUV39H1 physically interacts with HDAC1, HDAC2, and HDAC3 by co-immunoprecipitation; the N-terminal portion of SUV39H1 (not requiring its catalytic SET domain) constitutes a transcriptional repression domain that binds the core HDAC complex (HDAC1, HDAC2, RbAp48, RbAp46); repression of a heterologous promoter by SUV39H1 is dependent on histone deacetylase activity. Co-immunoprecipitation; reporter gene repression assay; HDAC inhibitor treatment Nucleic acids research Medium 11788710
2003 The chromo shadow domain of HP1α directly interacts with the N-terminal 39 amino acid stretch of SUV39H1; a self-interaction (dimerization) of HP1α through its chromo shadow domain is required for this direct binding; a consensus peptide that disrupts chromo shadow domain dimerization also inhibits HP1α–SUV39H1 interaction. Yeast two-hybrid; GST pulldown; interaction-disrupting peptide; point mutagenesis (IY165/168EE) Biochemical and biophysical research communications Medium 12565857
2004 Suv39h mediates H3K9 methylation at Rb/E2F target promoters specifically in differentiating (but not cycling) cells; siRNA knockdown of Suv39h prevents H3K9 methylation and subsequent repression of S-phase gene promoters in differentiating myoblasts, and Suv39h-depleted myoblasts fail to express muscle differentiation markers. Chromatin immunoprecipitation; siRNA knockdown; gene expression analysis in cycling vs. differentiating cells The EMBO journal Medium 14765126
2005 A substantial population of SUV39H1 is immobile at pericentromeric heterochromatin (FRAP analysis); the SET domain mediates this stable, structural binding to heterochromatin; recruitment of SUV39H1 to heterochromatin is at least partly independent of HP1; HP1 transiently interacts with SUV39H1 at heterochromatin (FRET). FRAP (fluorescence recovery after photobleaching); FRET; deletion mutant analysis in living cells The Journal of cell biology Medium 16103223
2006 Suv39h1 interacts with MyoD in proliferating muscle cells and its HMT activity is associated with the MyoD complex on the chromatin regulatory regions of the myogenin gene, correlating with H3K9 methylation; increased Suv39h1 represses MyoD-dependent muscle gene expression in a manner requiring both its HMT activity and its association with MyoD; siRNA-mediated abrogation of Suv39h1 activates muscle gene expression by MyoD. Co-immunoprecipitation; chromatin immunoprecipitation; overexpression; siRNA knockdown; reporter assays The EMBO journal Medium 16858404
2007 SIRT1 directly interacts with SUV39H1, recruits it, and deacetylates SUV39H1 at lysine 266 within its catalytic SET domain; acetylation at K266 inhibits SUV39H1 activity; SIRT1-mediated deacetylation independently contributes to elevated SUV39H1 H3K9me3 methyltransferase activity and increased H3K9me3 levels; loss of SIRT1 greatly reduces SUV39H1-dependent H3K9me3 and impairs HP1 localization. Co-immunoprecipitation; in vitro deacetylation assay; site-directed mutagenesis (K266); immunofluorescence; SIRT1 knockdown/knockout Nature High 18004385
2007 Suv39H1, HP1γ, and H3K9 trimethylation are reversibly associated with the integrated HIV-1 promoter in a transcription-dependent manner and play a major role in chromatin-mediated repression of HIV-1 gene expression and post-integration latency; knockdown of HP1γ (not SUV39H1 directly) by RNA interference reactivated HIV-1 in multiple cellular models including PBMCs from HIV-1-infected donors. Chromatin immunoprecipitation; siRNA knockdown; reporter assays; primary cell models The EMBO journal Medium 17245432
2010 A subset of H3K9 methyltransferases — G9a, GLP, SETDB1, and Suv39h1 — co-exist in the same megacomplex; in Suv39h or G9a null cells, the remaining HKMTs are destabilized at the protein level, indicating interdependence; all four HKMTs are recruited to major satellite repeats and to multiple G9a target genes, where they functionally cooperate. Co-immunoprecipitation; protein stability in null cells; chromatin immunoprecipitation Molecular cell Medium 20129054
2011 SirT1 controls global levels of Suv39h1 by increasing its protein half-life through inhibition of MDM2-dependent polyubiquitination of Suv39h1 at lysine 87; SirT1 upregulation (e.g., under calorie restriction) increases Suv39h1 protein levels in vivo; this mechanism regulates Suv39h1 turnover at constitutive heterochromatin and ensures genome integrity. Protein stability assays; ubiquitination assays; site-directed mutagenesis (K87); co-immunoprecipitation; in vivo calorie restriction model Molecular cell High 21504832
2012 Snail interacts with Suv39H1 via the SNAG domain of Snail and the SET domain of Suv39H1; Snail recruits Suv39H1 to the E-cadherin promoter, leading to H3K9me3 and DNA methylation-based transcriptional repression; knockdown of Suv39H1 restores E-cadherin expression and inhibits cell migration, invasion, and metastasis of basal-like breast cancer cells. Co-immunoprecipitation; chromatin immunoprecipitation; siRNA knockdown; domain mapping; cell migration/invasion assays; in vivo metastasis assay Oncogene Medium 22562246
2013 SET7/9 interacts with SUV39H1 (via the chromodomain-containing region of SUV39H1) in response to adriamycin treatment; SET7/9 methylates SUV39H1 at lysines 105 and 123 (confirmed by mass spectrometry and specific antibodies); this methylation dramatically downregulates SUV39H1 methyltransferase activity, reduces H3K9me3 at heterochromatin, causes heterochromatin relaxation (increased satellite repeat transcription, increased MNase sensitivity), genome instability, and inhibits cell proliferation. Co-immunoprecipitation; GST pulldown; mass spectrometry; western blot with methylation-specific antibodies; in vitro methyltransferase assay; MNase sensitivity assay; immunofluorescence Proceedings of the National Academy of Sciences of the United States of America High 23509280
2013 A-type lamins interact with SUV39H1; prelamin A/progerin exhibits enhanced binding capacity to SUV39H1 compared to mature lamin A, protecting SUV39H1 from proteasomal degradation and consequently increasing H3K9me3 levels; depletion of Suv39h1 reduces H3K9me3, restores DNA repair capacity, delays senescence in progeroid cells, and extends lifespan of Zmpste24−/− mice by ~60%. Co-immunoprecipitation; protein stability assays; siRNA/genetic Suv39h1 depletion; DNA repair assays; mouse lifespan analysis Nature communications High 23695662
2013 CRL4B (containing CUL4B) associates with SUV39H1, HP1, and DNMT3A; CRL4B, through catalyzing H2AK119 monoubiquitination, facilitates SUV39H1-dependent H3K9 trimethylation and DNA methylation; depletion of CUL4B results in loss of H3K9me3 and DNA methylation at target gene promoters. Co-immunoprecipitation; chromatin immunoprecipitation; siRNA knockdown; ubiquitination assays Oncogene Medium 24292684
2014 CDK2 directly phosphorylates Suv39H1 at Ser391; phosphorylation levels oscillate during the cell cycle, peaking at S phase; CDK2-mediated phosphorylation at Ser391 causes preferential dissociation of Suv39H1 from chromatin, enhances occupancy of JMJD2A histone demethylase on heterochromatin, alters inactive histone marks, and phospho-mimic Suv39H1 induces early replication of heterochromatin. In vitro kinase assay; phospho-specific antibodies; cell cycle synchronization; chromatin fractionation; overexpression of phospho-mimic/phospho-defective mutants; replication timing assay Nucleic acids research High 24728993
2014 Suv39h1 enhances AP-2α-mediated transcriptional repression of C/EBPα during adipogenesis; Suv39h1 interacts with AP-2α and with G9a; G9a mediates H3K9me2 at the C/EBPα promoter, providing the substrate for Suv39h1-mediated H3K9me3; knockdown of Suv39h1 increases C/EBPα expression and promotes adipogenesis, while Suv39h1 overexpression impairs adipocyte differentiation. Co-immunoprecipitation; chromatin immunoprecipitation; siRNA knockdown; overexpression; differentiation assays Molecular and cellular biology Medium 24732798
2014 Suv39h-dependent H3K9me3 selectively accumulates at intact (full-length) LINE elements and ERVs (~8,150 intact LINEs/ERVs) covering ~5% of the ES cell epigenome; transcriptional repression of intact LINEs and ERVs is differentially regulated by Suv39h and other chromatin modifiers in ES cells but governed by DNA methylation in committed cells. Genome-wide ChIP sequencing in Suv39h double-null vs. wild-type mouse ES cells; bioinformatic repeat subfamily analysis Molecular cell High 24981170
2016 Suv39h1 operates through a two-step allosteric activation switch: (1) H3K9me3 recognition by its chromodomain anchors the enzyme to chromatin, (2) this anchoring allosterically promotes methyltransferase activity, enabling positive feedback spreading of H3K9me2/3 over heterochromatic regions; this mechanism was confirmed in cells using chromodomain mutants. Semi-synthetic 'designer chromatin' reconstitution with chemically defined nucleosomal substrates; in vitro methyltransferase assay; mutagenesis of chromodomain; cellular confirmation Nature chemical biology High 26807716
2016 Suv39h1 promotes HP1α sumoylation both in vitro and in vivo through a region (aa1-167) distinct from its catalytic KMT domain that mediates binding to Ubc9; tethering this 1-167 domain to pericentric heterochromatin accelerates de novo targeting of HP1α to these domains; mutants unable to bind Ubc9 lack this activity. In vitro sumoylation assay; co-immunoprecipitation; tethering assay; mutagenesis Nature communications Medium 27426629
2017 Chromatin-associated RNA (encoded partly by α-satellite sequences, retained in cis) contributes to stable association of SUV39H1 with constitutive heterochromatin; purified SUV39H1 directly binds nucleic acids through its chromodomain; nucleic acid-binding mutants of SUV39H1 and RNase treatment or RNA polymerase inhibition destabilize SUV39H1 association with chromatin in mitotic and interphase cells and cause heterochromatin function defects. In vitro nucleic acid binding assay (purified protein); chromodomain mutagenesis; RNase treatment of cells; RNA polymerase inhibition; live-cell imaging; chromatin fractionation eLife High 28760200
2017 Suv39h2 (paralog) contains an N-terminal basic domain that facilitates retention at mitotic chromatin and provides additional affinity for major satellite repeat RNA; Suv39h1 (and Suv39h2) exclusively associate with poly-nucleosomes purified from mouse ES cells; this association is attenuated by RNaseH and entirely lost by RNaseA, indicating RNA:DNA hybrid-dependent and RNA-dependent chromatin association respectively; major satellite repeat transcripts have secondary structures favoring RNA:DNA hybrid formation. Native nucleosome purification; RNase treatment; EMSA; structural analysis of RNA eLife High 28760199
2017 Suv39h1's chromodomain binds nucleic acids (higher affinity for RNA than DNA) independently of H3K9me3 recognition; Suv39h1 binds major satellite RNAs in vivo; knockdown of major satellite RNAs reduces Suv39h1 retention at pericentromere; both nucleic acid-binding and H3K9me-binding activities of Suv39h1's chromodomain are required for pericentric heterochromatin assembly. EMSA with purified chromodomain; RNA immunoprecipitation in vivo; RNA knockdown; chromodomain mutagenesis; immunofluorescence eLife High 28760201
2017 SUV39H cooperates with HP1γ to catalyze H3K9 trimethylation on the SIRT1 promoter, thereby repressing SIRT1 transcription in cardiomyocytes under ischemic/oxidative stress; SUV39H knockout mice are protected from myocardial infarction, and SUV39H inhibition attenuates cardiac injury following MI; SUV39H augments intracellular ROS levels in a SIRT1-dependent manner. Chromatin immunoprecipitation; SUV39H knockout mice; pharmacological inhibition (chaetocin); gene expression analysis; cardiac function measurement Nature communications Medium 28361889
2017 SUV39H1 substrate specificity requires recognition of H3 residues between K4 and G12, with highly specific readout of R8; SUV39H1 methylates non-histone substrates including RAG2, SET8, and DOT1L in cells; methylation of SET8 allosterically stimulates its H4K20 monomethylation activity, connecting SUV39H1 to increased H4K20me3; methylation of RAG2 alters its subnuclear localization. Peptide array substrate specificity profiling; in vitro methyltransferase assay at protein level; cellular methylation confirmation; functional activity assay for SET8 ACS chemical biology Medium 28169523
2017 SUV39H1 methylates the mycobacterial histone-like protein HupB; this trimethylation reduces the cell adhesion capability of mycobacteria and reduces mycobacterial survival inside host cells and biofilm formation; SUV39H1 associates with mycobacterial bacilli during infection. In vitro methyltransferase assay; co-immunoprecipitation; bacterial adhesion assays; intracellular survival assays; mouse infection model The EMBO journal Medium 29170282
2018 Automethylation of specific lysines in an internal loop of Clr4 (the S. pombe ortholog of SUV39H) inhibits catalytic activity by blocking the H3K9 substrate-binding pocket; automethylation promotes a conformational switch that enhances H3K9me activity; mutations disrupting this regulation lead to aberrant H3K9me and epigenetic instability; a corresponding lysine in human SUV39H2 is also automethylated, suggesting conserved mechanism. X-ray crystallography; biochemical methyltransferase assays; mutagenesis; in vivo heterochromatin analysis in S. pombe Nature High 30051891
2018 SirT6 binds to Suv39h1 and induces monoubiquitination of conserved cysteines in the PRE-SET domain of Suv39h1; following NF-κB signaling activation, Suv39h1 is released from the IκBα locus; SirT6-mediated cysteine monoubiquitination of Suv39h1 attenuates NF-κB pathway activity through IκBα upregulation. Co-immunoprecipitation; ubiquitination assay; chromatin immunoprecipitation; site-directed mutagenesis; NF-κB reporter assays Nature communications Medium 29317652
2018 CRL4-DCAF13 E3 ubiquitin ligase targets SUV39H1 for polyubiquitination and proteasomal degradation; Dcaf13 knockout embryos are arrested at the 8–16 cell stage with high levels of H3K9me3; DCAF13-mediated SUV39H1 degradation facilitates H3K9me3 removal and zygotic gene expression during preimplantation development. Co-immunoprecipitation; ubiquitination assays; Dcaf13 knockout mice; embryo arrest phenotype; immunofluorescence The EMBO journal High 30111536
2012 SUV39H1 orchestrates temporal dynamics of H3K9 methylation at the centromere during chromosome segregation; inhibition of SUV39H1 methylation dynamics perturbs chromosome congression, causes a brief increase in Aurora B kinase activity, enrichment of MCAK at centromeres, kinetochore-microtubule destabilization, reduced tension across sister kinetochores, and chromosome misalignment. FRET-based methylation sensors targeted to centromeres in living HeLa cells; immunofluorescence; pharmacological SUV39H1 inhibition (chaetocin) Journal of molecular cell biology Medium 22831836
2013 N-terminally truncated Suv39h1 (ΔN, HP1-binding defective) introduced into Suv39h-deficient ES cells recovers pericentric H3K9me3 and Dnmt3a/3b accumulation and DNA methylation at pericentromeres, but only marginally restores HP1 accumulation; Suv39h-HP1 direct binding is dispensable for pericentric H3K9me3 and DNA methylation but is required for full HP1 recruitment and complete heterochromatin features (ATRX association, H4K20me3). Reconstitution of truncation mutants in Suv39h-null ES cells; immunofluorescence; ChIP; bisulfite sequencing The Journal of biological chemistry Medium 23836914
2017 HP1α and HP1γ (but not HP1β) preferentially interact in vivo with Suv39h1 and regulate its dynamics and stability at heterochromatin by inhibiting MDM2-dependent Suv39h1-K87 polyubiquitination; reciprocally, Suv39h1 increases HP1α stability; loss of HP1α and γ inhibits stress-induced upregulation of Suv39h1 and H3K9me3; Suv39h1 deficiency abrogates stress-dependent upregulation of HP1α and γ. Co-immunoprecipitation; FRAP; protein stability assays; ubiquitination assays; isoform-specific knockdown Epigenetics Medium 28059589
2024 H3K18ub (catalyzed by UHRF1) enhances SUV39H1/H2 methyltransferase activity; disrupting H3K18ub-dependent SUV39H1/H2 activity prevents H3K9me3 accumulation at CpG island promoters following DNMT1 inhibition and enhances transcriptional activating and antiproliferative effects of DNMT1 inhibition. Genome-wide ChIP-seq; in vitro methyltransferase activity assay with H3K18ub nucleosomes; genetic disruption of UHRF1; colon cancer cell models Molecular cell Medium 39631394
2024 Genetic disruption of SUV39H1 in CAR T cells enhances early expansion, long-term persistence, and antitumor efficacy in leukemia and prostate cancer models; SUV39H1-edited CAR T cells show improved memory transcription factor accessibility, reduced inhibitory receptor expression, and reduced exhaustion upon multiple tumor rechallenges. Genetic CRISPR editing of SUV39H1 in human CAR T cells; scRNA-seq; scATAC-seq; in vivo tumor rechallenge models Cancer discovery Medium 37934007

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2001 Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability. Cell 1404 11701123
2003 Suv39h-mediated histone H3 lysine 9 methylation directs DNA methylation to major satellite repeats at pericentric heterochromatin. Current biology : CB 955 12867029
2003 The DNA methyltransferases associate with HP1 and the SUV39H1 histone methyltransferase. Nucleic acids research 571 12711675
2007 SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation. Nature 361 18004385
2008 PRC1 and Suv39h specify parental asymmetry at constitutive heterochromatin in early mouse embryos. Nature genetics 276 18311137
2010 A subset of the histone H3 lysine 9 methyltransferases Suv39h1, G9a, GLP, and SETDB1 participate in a multimeric complex. Molecular cell 270 20129054
2007 Suv39H1 and HP1gamma are responsible for chromatin-mediated HIV-1 transcriptional silencing and post-integration latency. The EMBO journal 265 17245432
2014 Suv39h-dependent H3K9me3 marks intact retrotransposons and silences LINE elements in mouse embryonic stem cells. Molecular cell 259 24981170
2012 Interaction with Suv39H1 is critical for Snail-mediated E-cadherin repression in breast cancer. Oncogene 170 22562246
2004 A Suv39h-dependent mechanism for silencing S-phase genes in differentiating but not in cycling cells. The EMBO journal 167 14765126
2000 Structure-function analysis of SUV39H1 reveals a dominant role in heterochromatin organization, chromosome segregation, and mitotic progression. Molecular and cellular biology 167 10779362
2017 Major satellite repeat RNA stabilize heterochromatin retention of Suv39h enzymes by RNA-nucleosome association and RNA:DNA hybrid formation. eLife 151 28760199
2017 RNA-dependent stabilization of SUV39H1 at constitutive heterochromatin. eLife 137 28760200
2002 Functional and physical interaction between the histone methyl transferase Suv39H1 and histone deacetylases. Nucleic acids research 136 11788710
2006 Zebra fish Dnmt1 and Suv39h1 regulate organ-specific terminal differentiation during development. Molecular and cellular biology 126 16980612
2013 Depleting the methyltransferase Suv39h1 improves DNA repair and extends lifespan in a progeria mouse model. Nature communications 122 23695662
2011 Stabilization of Suv39H1 by SirT1 is part of oxidative stress response and ensures genome protection. Molecular cell 116 21504832
2003 pRb2/p130-E2F4/5-HDAC1-SUV39H1-p300 and pRb2/p130-E2F4/5-HDAC1-SUV39H1-DNMT1 multimolecular complexes mediate the transcription of estrogen receptor-alpha in breast cancer. Oncogene 113 12789259
2008 Gestational choline supply regulates methylation of histone H3, expression of histone methyltransferases G9a (Kmt1c) and Suv39h1 (Kmt1a), and DNA methylation of their genes in rat fetal liver and brain. The Journal of biological chemistry 106 19001366
2006 Histone methyltransferase Suv39h1 represses MyoD-stimulated myogenic differentiation. The EMBO journal 104 16858404
2009 p21(WAF1) gene promoter is epigenetically silenced by CTIP2 and SUV39H1. Oncogene 101 19581932
2006 Histone H3 lysine 9 and H4 lysine 20 trimethylation and the expression of Suv4-20h2 and Suv-39h1 histone methyltransferases in hepatocarcinogenesis induced by methyl deficiency in rats. Carcinogenesis 101 16497704
2000 Mitotic phosphorylation of SUV39H1, a novel component of active centromeres, coincides with transient accumulation at mammalian centromeres. Journal of cell science 100 10671371
2013 CRL4B promotes tumorigenesis by coordinating with SUV39H1/HP1/DNMT3A in DNA methylation-based epigenetic silencing. Oncogene 99 24292684
2010 Ring1B and Suv39h1 delineate distinct chromatin states at bivalent genes during early mouse lineage commitment. Development (Cambridge, England) 96 20573702
2009 Reexpression of epigenetically silenced AML tumor suppressor genes by SUV39H1 inhibition. Oncogene 93 19881540
2018 Norisoboldine, a natural AhR agonist, promotes Treg differentiation and attenuates colitis via targeting glycolysis and subsequent NAD+/SIRT1/SUV39H1/H3K9me3 signaling pathway. Cell death & disease 92 29449535
2017 The histone H3K9 methyltransferase SUV39H links SIRT1 repression to myocardial infarction. Nature communications 91 28361889
2016 A two-state activation mechanism controls the histone methyltransferase Suv39h1. Nature chemical biology 91 26807716
2013 Methylation of SUV39H1 by SET7/9 results in heterochromatin relaxation and genome instability. Proceedings of the National Academy of Sciences of the United States of America 91 23509280
2015 Epigenetic silencing of Oct4 by a complex containing SUV39H1 and Oct4 pseudogene lncRNA. Nature communications 88 26158551
2014 Histone lysine methyltransferase SUV39H1 is a potent target for epigenetic therapy of hepatocellular carcinoma. International journal of cancer 88 24844570
2003 Self-interaction of heterochromatin protein 1 is required for direct binding to histone methyltransferase, SUV39H1. Biochemical and biophysical research communications 88 12565857
2016 Age-Associated Decrease of the Histone Methyltransferase SUV39H1 in HSC Perturbs Heterochromatin and B Lymphoid Differentiation. Stem cell reports 86 27304919
2020 SUV39H1 deficiency suppresses clear cell renal cell carcinoma growth by inducing ferroptosis. Acta pharmaceutica Sinica. B 82 33643820
2017 Impact of nucleic acid and methylated H3K9 binding activities of Suv39h1 on its heterochromatin assembly. eLife 82 28760201
2018 ALDH2 protects against high fat diet-induced obesity cardiomyopathy and defective autophagy: role of CaM kinase II, histone H3K9 methyltransferase SUV39H, Sirt1, and PGC-1α deacetylation. International journal of obesity (2005) 80 29535452
2013 Role of histone lysine methyltransferases SUV39H1 and SETDB1 in gliomagenesis: modulation of cell proliferation, migration, and colony formation. Neuromolecular medicine 80 23943221
2016 KAT7/HBO1/MYST2 Regulates CENP-A Chromatin Assembly by Antagonizing Suv39h1-Mediated Centromere Inactivation. Developmental cell 79 27270040
2009 Inhibition of SUV39H1 methyltransferase activity by DBC1. The Journal of biological chemistry 77 19218236
2015 The SUV39H1 inhibitor chaetocin induces differentiation and shows synergistic cytotoxicity with other epigenetic drugs in acute myeloid leukemia cells. Blood cancer journal 76 25978433
2010 RFX1 regulates CD70 and CD11a expression in lupus T cells by recruiting the histone methyltransferase SUV39H1. Arthritis research & therapy 68 21192791
2018 DCAF13 promotes pluripotency by negatively regulating SUV39H1 stability during early embryonic development. The EMBO journal 67 30111536
2024 Disruption of SUV39H1-Mediated H3K9 Methylation Sustains CAR T-cell Function. Cancer discovery 66 37934007
2009 EVI-1 interacts with histone methyltransferases SUV39H1 and G9a for transcriptional repression and bone marrow immortalization. Leukemia 65 19776757
2018 Automethylation-induced conformational switch in Clr4 (Suv39h) maintains epigenetic stability. Nature 64 30051891
2005 A glue for heterochromatin maintenance: stable SUV39H1 binding to heterochromatin is reinforced by the SET domain. The Journal of cell biology 63 16103223
2006 RUNX1 associates with histone deacetylases and SUV39H1 to repress transcription. Oncogene 61 16652147
2003 SUV39H1 interacts with AML1 and abrogates AML1 transactivity. AML1 is methylated in vivo. Oncogene 60 12917624
2019 Interplay among H3K9-editing enzymes SUV39H1, JMJD2C and SRC-1 drives p66Shc transcription and vascular oxidative stress in obesity. European heart journal 59 29077881
2011 Anti-leukemia activity of chaetocin via death receptor-dependent apoptosis and dual modulation of the histone methyl-transferase SUV39H1. Leukemia 58 21979880
2013 p53 promotes repair of heterochromatin DNA by regulating JMJD2b and SUV39H1 expression. Oncogene 57 23376847
2019 SUV39H1 Represses the Expression of Cytotoxic T-Lymphocyte Effector Genes to Promote Colon Tumor Immune Evasion. Cancer immunology research 55 30610059
2017 The KMT1A-GATA3-STAT3 Circuit Is a Novel Self-Renewal Signaling of Human Bladder Cancer Stem Cells. Clinical cancer research : an official journal of the American Association for Cancer Research 53 28765327
2011 Genetic examination of SETD7 and SUV39H1/H2 methyltransferases and the risk of diabetes complications in patients with type 1 diabetes. Diabetes 53 21896933
2007 The Suv39h-HP1 histone methylation pathway is dispensable for enrichment and protection of cohesin at centromeres in mammalian cells. Chromosoma 53 18075750
2019 IFI16, a nuclear innate immune DNA sensor, mediates epigenetic silencing of herpesvirus genomes by its association with H3K9 methyltransferases SUV39H1 and GLP. eLife 51 31682228
2018 SIRT6-dependent cysteine monoubiquitination in the PRE-SET domain of Suv39h1 regulates the NF-κB pathway. Nature communications 51 29317652
2001 Over-expression of the SUV39H1 histone methyltransferase induces altered proliferation and differentiation in transgenic mice. Mechanisms of development 49 11520670
2008 A novel interaction between the proto-oncogene Evi1 and histone methyltransferases, SUV39H1 and G9a. FEBS letters 46 18619962
2019 Class II transactivator (CIITA) mediates IFN-γ induced eNOS repression by enlisting SUV39H1. Biochimica et biophysica acta. Gene regulatory mechanisms 45 30716531
2008 EVI1 recruits the histone methyltransferase SUV39H1 for transcription repression. Journal of cellular biochemistry 45 18655152
2024 SUV39H1 Ablation Enhances Long-term CAR T Function in Solid Tumors. Cancer discovery 44 37934001
2019 Alpinetin improves intestinal barrier homeostasis via regulating AhR/suv39h1/TSC2/mTORC1/autophagy pathway. Toxicology and applied pharmacology 43 31676321
2017 SUV39H1 mediated SIRT1 trans-repression contributes to cardiac ischemia-reperfusion injury. Basic research in cardiology 43 28271186
2017 Metformin inhibits SUV39H1-mediated migration of prostate cancer cells. Oncogenesis 43 28459432
2011 Epigenetic regulation of surfactant protein A gene (SP-A) expression in fetal lung reveals a critical role for Suv39h methyltransferases during development and hypoxia. Molecular and cellular biology 43 21402781
2015 Inhibition of histone methyltransferases SUV39H1 and G9a leads to neuroprotection in an in vitro model of cerebral ischemia. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 42 25966950
2022 CD8+T cell responsiveness to anti-PD-1 is epigenetically regulated by Suv39h1 in melanomas. Nature communications 41 35768432
2014 Suv39h1 mediates AP-2α-dependent inhibition of C/EBPα expression during adipogenesis. Molecular and cellular biology 41 24732798
2021 Structure, Activity and Function of the Suv39h1 and Suv39h2 Protein Lysine Methyltransferases. Life (Basel, Switzerland) 40 34357075
2016 Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs. Molecular cell 40 27984744
2016 Histone H2AK119 and H2BK120 mono-ubiquitination modulate SET7/9 and SUV39H1 in type 1 diabetes-induced renal fibrosis. The Biochemical journal 39 27582499
2020 SUV39H1-DNMT3A-mediated epigenetic regulation of Tim-3 and galectin-9 in the cervical cancer. Cancer cell international 37 32699524
2020 CD74 knockout protects against LPS-induced myocardial contractile dysfunction through AMPK-Skp2-SUV39H1-mediated demethylation of BCLB. British journal of pharmacology 36 31877229
2012 SUV39H1 orchestrates temporal dynamics of centromeric methylation essential for faithful chromosome segregation in mitosis. Journal of molecular cell biology 36 22831836
2020 SUV39H1 regulates human colon carcinoma apoptosis and cell cycle to promote tumor growth. Cancer letters 35 32061753
2006 SUV39H1 interacts with HTLV-1 Tax and abrogates Tax transactivation of HTLV-1 LTR. Retrovirology 35 16409643
2022 LncRNA HOTAIR promotes the proliferation and invasion/metastasis of breast cancer cells by targeting the miR-130a-3p/Suv39H1 axis. Biochemistry and biophysics reports 32 35619625
2018 SUV39H1/DNMT3A-dependent methylation of the RB1 promoter stimulates PIN1 expression and melanoma development. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 32 29750576
2016 The methyltransferase Suv39h1 links the SUMO pathway to HP1α marking at pericentric heterochromatin. Nature communications 32 27426629
2020 SUV39H1 regulates the progression of MLL-AF9-induced acute myeloid leukemia. Oncogene 31 33037410
2017 The SUV39H1 Protein Lysine Methyltransferase Methylates Chromatin Proteins Involved in Heterochromatin Formation and VDJ Recombination. ACS chemical biology 31 28169523
2014 Aberrant histone methylation and the effect of Suv39H1 siRNA on gastric carcinoma. Oncology reports 31 24737085
2014 Suv39h1 protects from myocardial ischemia-reperfusion injury in diabetic rats. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 31 24752040
2018 Functional Role of SUV39H1 in Human Renal Tubular Epithelial Cells Under High-glucose Ambiance. Inflammation 30 28852907
2018 Epigenetic silenced miR-125a-5p could be self-activated through targeting Suv39H1 in gastric cancer. Journal of cellular and molecular medicine 30 30117667
2013 The histone methyltransferase SUV39H1 suppresses embryonal rhabdomyosarcoma formation in zebrafish. PloS one 30 23705022
2011 Histone methyltransferase KMT1A restrains entry of alveolar rhabdomyosarcoma cells into a myogenic differentiated state. Cancer research 30 21493592
2009 SUV39h-independent association of HP1 beta with fibrillarin-positive nucleolar regions. Chromosoma 30 20033197
2017 Histone methyltransferase SUV39H1 participates in host defense by methylating mycobacterial histone-like protein HupB. The EMBO journal 29 29170282
2014 CDK2-dependent phosphorylation of Suv39H1 is involved in control of heterochromatin replication during cell cycle progression. Nucleic acids research 28 24728993
2012 H3K9 trimethylation precedes DNA methylation during sheep oogenesis: HDAC1, SUV39H1, G9a, HP1, and Dnmts are involved in these epigenetic events. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 27 23019017
2024 DNA hypomethylation promotes UHRF1-and SUV39H1/H2-dependent crosstalk between H3K18ub and H3K9me3 to reinforce heterochromatin states. Molecular cell 26 39631394
2024 Histone methyltransferase Suv39h1 regulates hepatic stellate cell activation and is targetable in liver fibrosis. Gut 25 38176898
2019 Kindlin-2 suppresses transcription factor GATA4 through interaction with SUV39H1 to attenuate hypertrophy. Cell death & disease 23 31767831
2013 Pericentric heterochromatin generated by HP1 protein interaction-defective histone methyltransferase Suv39h1. The Journal of biological chemistry 23 23836914
2019 Suv39h1 promotes facet joint chondrocyte proliferation by targeting miR-15a/Bcl2 in idiopathic scoliosis patients. Clinical epigenetics 22 31337422
2004 Suv39h histone methyltransferases interact with Smads and cooperate in BMP-induced repression. Oncogene 22 15107829
2017 An HP1 isoform-specific feedback mechanism regulates Suv39h1 activity under stress conditions. Epigenetics 21 28059589

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