Affinage

Showing BCAP31 — BAP31 is a alias.

BCAP31

B-cell receptor-associated protein 31 · UniProt P51572

Length
246 aa
Mass
28.0 kDa
Annotated
2026-06-09
100 papers in source corpus 48 papers cited in narrative 48 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 8/8 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

BCAP31 (BAP31) is a polytopic ER integral membrane protein that functions as a broad-specificity chaperone and quality-control factor governing ER retention, export, and ERAD of client transmembrane proteins, and as a scaffold that couples the ER to mitochondria for both apoptotic and metabolic signaling (PMID:9334338, PMID:9396746, PMID:18555783). As a cargo/retention factor it controls ER-to-Golgi anterograde transport (cellubrevin export depends on its cytoplasmic tail) (PMID:9396746), retains immature or unassembled clients in the ER (membrane IgD, cytochrome P450 2C2) (PMID:12886015, PMID:16332681), promotes export and stabilization of peptide-loaded MHC class I (PMID:17056546, PMID:19342655), and supports surface delivery of tetraspanins CD9/CD81 to sustain integrin-mediated adhesion and survival (PMID:15946936); it itinerates between peripheral ER and a juxtanuclear quality-control compartment in a microtubule- and dynein-dynactin-dependent manner (PMID:18287538). Through association with the Sec61 translocon components Sec61β/TRAM and the Derlin-1 dislocation complex, BAP31 directs retrotranslocation and proteasomal degradation of misfolded clients such as ΔF508-CFTR (PMID:18555783). BAP31 is also a central apoptosis regulator: full-length BAP31 forms a complex with Bcl-2/Bcl-XL and procaspase-8(L) and inhibits BAX/BAK oligomerization and cytochrome c release, while caspase-8/caspase-1 cleavage generates a pro-apoptotic p20 fragment that triggers ER Ca²⁺ release, Drp1-dependent mitochondrial fission, and sensitization to cytochrome c release (PMID:9334338, PMID:10958671, PMID:11917123, PMID:12668660, PMID:12529377). This apoptotic platform is assembled at ER-mitochondria contacts with Fis1 (the 'ARCosome') and is engaged during ER stress through CDIP1 (PMID:21183955, PMID:24139803), with the BAP31 vDED region — structurally a coiled coil — directly binding the TPR domain of Fis1 (PMID:23967155, PMID:40770055). At ER-mitochondria contacts BAP31 additionally tethers the mitochondrial import receptor Tom40 to deliver the complex I subunit NDUFS4 and support oxidative phosphorylation (PMID:31206022). Loss-of-function mutations in BCAP31 in humans disrupt ER and Golgi morphology, establishing its requirement for ER-to-Golgi homeostasis (PMID:24011989). Its activity is modulated by post-translational modification, including PINK1-mediated phosphorylation at Ser142 and sirtuin 2-mediated deacetylation at Lys158 (PMID:41022756, PMID:39887347).

Mechanistic history

Synthesis pass · year-by-year structured walk · 20 steps
  1. 1997 High

    Established BAP31 as an ER membrane scaffold linking Bcl-2 family survival proteins to caspase-8, defining a caspase-cleavable substrate whose p20 product is itself pro-apoptotic.

    Evidence Reciprocal Co-IP in 293T cells, in vitro caspase cleavage with mutagenesis of AAVD sites, and ectopic p20 expression

    PMID:9334338

    Open questions at the time
    • Did not establish the physiological trigger for cleavage in intact cells
    • Did not localize the activity to ER-mitochondria contacts
  2. 1996 Medium

    Identified BAP31/BAP29 as transmembrane-domain-selective binding partners of membrane immunoglobulin, first hinting at a cargo/retention role for ER-resident clients.

    Evidence Mutagenesis of the IgD delta-m transmembrane domain with Co-IP

    PMID:8612576

    Open questions at the time
    • Functional consequence (retention vs export) of the IgD interaction not yet defined
    • Generality beyond IgD untested
  3. 1997 High

    Demonstrated that BAP31 actively controls ER export of a specific cargo, distinguishing a chaperone/export-receptor function from generic ER residence.

    Evidence Co-IP and recombinant pulldown with cellubrevin plus cytoplasmic-tail truncation mutants and nocodazole treatment in fibroblasts

    PMID:9396746

    Open questions at the time
    • Did not define the COPII/export machinery BAP31 engages
    • Cargo selectivity rules not established
  4. 2000 High

    Showed that cleavage status converts BAP31 from a survival factor to a death signal, revealing ER-mitochondria crosstalk in Fas apoptosis.

    Evidence Stable caspase-resistant crBAP31 mutant in KB cells with cytochrome c release and mitochondrial readouts

    PMID:10958671

    Open questions at the time
    • Molecular relay from ER cleavage to mitochondria not yet identified
    • Identity of mitochondrial effectors unknown at this stage
  5. 2002 High

    Placed BAP31/BAP29 epistatically upstream of procaspase-8L processing via a FADD-independent, Bcl-2-inhibitable route, defining a death-receptor-independent caspase-8 activation platform.

    Evidence BAP31/BAP29 gene deletion in mouse cells, dominant-negative Nex domain, Co-IP and caspase assays

    PMID:11917123

    Open questions at the time
    • Spatial assembly of the platform not yet resolved
    • Stimulus specificity beyond E1A not fully mapped
  6. 2003 High

    Resolved how p20 reaches mitochondria, showing it drives ER Ca²⁺ release and Drp1-dependent fission that sensitizes mitochondria to cytochrome c release.

    Evidence Adenoviral p20 expression with Ca²⁺ imaging, mitochondrial morphology, Drp1 dominant-negative and cytochrome c assays

    PMID:12668660

    Open questions at the time
    • Direct molecular target of p20 at the ER/mitochondria not defined
    • How Ca²⁺ release is gated by p20 unresolved
  7. 2003 High

    Defined the anti-apoptotic arm of full-length BAP31 as direct inhibition of BAX/BAK oligomerization, in partnership with the A4 ER channel protein and independent of p20 generation.

    Evidence Split-ubiquitin Y2H, Co-IP, Bap31-null reconstitution and inducible FKBPcasp8 cytochrome c assays

    PMID:12529377

    Open questions at the time
    • Mechanism by which BAP31 restrains BAX/BAK not structurally defined
    • Role of A4 channel activity unresolved
  8. 1997 Medium

    Extended BAP31 quality control to disease-relevant transmembrane clients, showing it retains and limits surface delivery of CFTR.

    Evidence Antisense knockdown in CHO cells, Xenopus oocyte co-expression electrophysiology and colocalization (combined 2001 finding)

    PMID:11274174

    Open questions at the time
    • Did not distinguish retention from degradation at this stage
    • ERAD machinery not yet linked
  9. 2004 Medium

    Broadened BAP31's role to active ER membrane protein quality control by showing it stabilizes a client (PTPLB) against proteasomal turnover.

    Evidence Split-ubiquitin cDNA screen, Bap31-null reconstitution and proteasome-inhibitor turnover assays

    PMID:15024066

    Open questions at the time
    • Whether stabilization reflects folding assistance or degradation shielding unclear
    • Recognition determinants on clients unknown
  10. 2005 High

    Connected BAP31 quality control to cell physiology by linking tetraspanin surface delivery to integrin-mediated adhesion and apoptotic sensitivity.

    Evidence Bap31-null cells, reconstitution, p20 expression, flow cytometry and adhesion/apoptosis assays

    PMID:15946936

    Open questions at the time
    • Direct binding to CD9/CD81 versus indirect chaperoning not fully resolved
    • Mechanism of p20 inhibition of egress unclear
  11. 2006 Medium

    Showed BAP31 promotes ER export and stabilization of peptide-loaded MHC class I, with the paralog BAP29 acting oppositely, refining its export-receptor function.

    Evidence YFP-Bap31 chimeras, surface class I flow cytometry and pulse-chase in HeLa cells (with 2009 FRET follow-up)

    PMID:17056546 PMID:19342655

    Open questions at the time
    • Structural basis of peptide-loading-dependent recognition undefined
    • Quantitative contribution to antigen presentation in vivo not established
  12. 2008 High

    Mechanistically integrated BAP31 into ERAD by showing it associates with Sec61β/TRAM and the Derlin-1 complex to drive retrotranslocation and degradation of ΔF508-CFTR.

    Evidence Co-IP with translocon/dislocation components, siRNA depletion, pulse-chase and surface biotinylation

    PMID:18555783

    Open questions at the time
    • How BAP31 selects clients for export versus dislocation not resolved
    • Stoichiometry within the dislocation complex unknown
  13. 2008 High

    Defined the itinerant cycling behavior and transmembrane-domain determinants underlying BAP31 trafficking between peripheral and juxtanuclear ER compartments.

    Evidence Live GFP-Bap31 imaging, FRAP, dominant-negative Sar1p/Arf1, nocodazole, dynein-dynactin disruption and TMD deletions

    PMID:18287538

    Open questions at the time
    • Functional role of juxtanuclear cycling in quality control not established
    • Cargo coupling to the cycling pathway unresolved
  14. 2010 High

    Localized the apoptotic platform to ER-mitochondria contacts by identifying the Fis1-BAP31 'ARCosome' that recruits and activates procaspase-8 via the vDED domain.

    Evidence Co-IP, Fis1/BAP31 overexpression and knockdown, vDED mutants and Ca²⁺ release measurements

    PMID:21183955

    Open questions at the time
    • Trigger that nucleates ARCosome assembly not defined
    • Quantitative Ca²⁺ feedback parameters unresolved
  15. 2013 High

    Linked ER stress to the BAP31 death platform by showing the p53 target CDIP1 binds BAP31, enables its cleavage, and recruits Bcl-2 to drive apoptosis.

    Evidence Co-IP, ER stress induction, CDIP1 knockout mice, BAP31 cleavage, caspase-8 and BAX oligomerization assays

    PMID:24139803

    Open questions at the time
    • How CDIP1 binding licenses cleavage mechanistically unclear
    • Interplay with the Fis1 ARCosome not integrated
  16. 2013 High

    Provided structural insight that the BAP31 vDED is not a canonical DED but a parallel coiled coil, reframing how it scaffolds caspase recruitment.

    Evidence X-ray crystallography of the vDED with CD and SEC solution validation

    PMID:23967155

    Open questions at the time
    • Structure of the full caspase-8/CED-4-bound complex unsolved
    • Functional coupling of the coiled coil to caspase activation untested structurally
  17. 2013 Medium

    Linked human BCAP31 loss-of-function to organelle morphology, establishing an in vivo requirement for ER-to-Golgi homeostasis distinct from the apoptotic/UPR axis.

    Evidence Patient-derived fibroblasts with LoF mutations, ER/Golgi immunofluorescence and UPR/cell-death marker assays

    PMID:24011989

    Open questions at the time
    • Molecular basis of Golgi disorganization undefined
    • Which cargo defects drive the morphological phenotype unknown
  18. 2019 High

    Established a non-apoptotic metabolic role for BAP31 as an ER-mitochondria tether that delivers NDUFS4 to mitochondria via Tom40 to support complex I activity.

    Evidence Co-IP, NDUFS4 translocation, complex I activity and oxygen consumption assays with BAP31 knockdown

    PMID:31206022

    Open questions at the time
    • How the same contact site partitions apoptotic versus import functions unclear
    • Generality to other imported subunits untested
  19. 2025 High

    Defined the atomic interface of the apoptotic tether, showing the BAP31 vDED engages the convex TPR surface of Fis1 with evidence for a Fis1 autoinhibitory arm.

    Evidence X-ray crystallography of Fis1 alone and the Fis1-Bap31_vDED co-complex

    PMID:40770055

    Open questions at the time
    • How procaspase-8 docks onto this interface not resolved
    • Regulation of the proposed autoinhibitory arm in cells untested
  20. 2025 Medium

    Identified post-translational control of BAP31 stability and activity through PINK1 phosphorylation at Ser142 and sirtuin 2 deacetylation at Lys158.

    Evidence Co-IP, site-directed S142A/S142E mutagenesis with ER-stress apoptosis readouts; SIRT2 knockdown and K158 acetylation mapping in liver injury models

    PMID:39887347 PMID:41022756

    Open questions at the time
    • How these modifications alter BAP31 conformation or partner binding mechanistically unclear
    • Crosstalk between phosphorylation and acetylation untested

Open questions

Synthesis pass · forward-looking unresolved questions
  • How BAP31 mechanistically partitions its many client and signaling roles — chaperone/export versus ERAD versus apoptotic scaffold versus mitochondrial tether — at a single ER-mitochondria platform remains unresolved.
  • No unified structural model of client recognition
  • Rules determining export versus dislocation versus retention undefined
  • Spatial/temporal switch between survival and death functions not mapped

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0038024 cargo receptor activity 3 GO:0044183 protein folding chaperone 3 GO:0060090 molecular adaptor activity 3 GO:0098772 molecular function regulator activity 2
Localization
GO:0005783 endoplasmic reticulum 4 GO:0005739 mitochondrion 2 GO:0031410 cytoplasmic vesicle 2 GO:0005811 lipid droplet 1
Pathway
R-HSA-5357801 Programmed Cell Death 5 R-HSA-392499 Metabolism of proteins 3 R-HSA-9609507 Protein localization 3 R-HSA-5653656 Vesicle-mediated transport 2
Partners
BCL2L1CASP8CDIP1FIS1PINK1SEC61BSTX17TOMM40
Complex memberships
ARCosome (Fis1-BAP31-procaspase-8 platform)BAP31-Bcl-2/Bcl-XL-procaspase-8 complexBAP31-Tom40 ER-mitochondria tetherDerlin-1 dislocation complex

Evidence

Reading pass · 48 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1997 BAP31 (p28) is a polytopic integral ER membrane protein that forms a complex with Bcl-2/Bcl-XL and procaspase-8 (FLICE). Caspase-8 and caspase-1 (but not caspase-3) cleave BAP31 at two identical AAVD.G caspase recognition sites in vitro, generating a p20 fragment. Bax prevents Bcl-2 from associating with the complex. The p20 fragment induces apoptosis when expressed ectopically. Co-immunoprecipitation in co-transfected 293T cells; in vitro caspase cleavage assays; ectopic expression of p20 fragment The Journal of cell biology High 9334338
1996 BAP31 preferentially associates with membrane IgD but not IgM, and specific amino acids in the transmembrane sequence of the IgD heavy chain (delta-m chain) are critical for binding to BAP29/BAP31, as determined by mutational analysis. Mutagenesis of IgD transmembrane domain; co-immunoprecipitation; cloning and sequence analysis The EMBO journal Medium 8612576
1997 BAP31 controls ER-to-Golgi anterograde transport of cellubrevin; BAP31 and cellubrevin interact via their transmembrane regions (sensitive to high ionic strength); truncation of the BAP31 cytoplasmic tail prevents ER export of cellubrevin but not of the transferrin receptor. BAP31 localizes to the ER and a paranuclear vesicular compartment dependent on intact microtubules. Co-immunoprecipitation from fibroblast detergent extracts; affinity pulldown with recombinant cellubrevin; immunocytochemistry; BAP31 cytoplasmic-tail truncation mutants; nocodazole treatment The Journal of cell biology High 9396746
1998 The predicted death effector homology (vDED) domain in the cytosolic region of BAP31 interacts with CED-4, which in turn contributes to recruitment of procaspase-8 to the BAP31 complex. Bcl-XL binds directly but weakly to the transmembrane region of BAP31, and indirectly and cooperatively to the cytosolic domain dependent on procaspase-8 and CED-4. CED-4Δc displaces Bcl-XL from the complex. Co-immunoprecipitation in co-transfected human cells; domain-mapping experiments The Journal of biological chemistry Medium 9452422
2000 Caspase-resistant BAP31 (crBAP31, with AAVD→AAVA mutations) blocks Fas-mediated cytochrome c release from mitochondria and membrane fragmentation, demonstrating that uncleaved full-length BAP31 is an inhibitor of these apoptotic events. The data reveal unexpected ER-mitochondria crosstalk during Fas apoptosis mediated through BAP31 cleavage status. Stable expression of caspase-resistant BAP31 mutant in KB epithelial cells; Fas stimulation; measurement of cytochrome c release, caspase activation, phosphatidylserine redistribution, mitochondrial membrane potential Molecular and cellular biology High 10958671
2001 BAP31 controls expression and ER-membrane retention of CFTR; antisense inhibition of BAP31 increases CFTR expression and enables cAMP-activated Cl⁻ currents in ΔF508-CFTR-expressing CHO cells; coexpression of CFTR with BAP31 attenuates cAMP-activated Cl⁻ currents in Xenopus oocytes. BAP31 and CFTR colocalize in the cytosol. Antisense knockdown of BAP31 in CHO cells; co-expression in Xenopus oocytes with electrophysiology; immunofluorescence colocalization The Journal of biological chemistry Medium 11274174
2002 Procaspase-8L, characterized by an N-terminal extension (Nex) domain, is selectively recruited to the BAP31 complex at the ER via its Nex domain. Gene deletion of BAP31 and the related BAP29 impairs processing of procaspase-8L in response to E1A by a FADD-independent, BCL-2-inhibitable mechanism, and curtails downstream caspase activation and cell death. BAP31/BAP29 gene deletion in mouse cells; dominant-negative Nex-domain mutant; co-immunoprecipitation; caspase activity assays Proceedings of the National Academy of Sciences of the United States of America High 11917123
2003 The p20 caspase-8 cleavage fragment of BAP31 triggers Ca²⁺ release from the ER, concomitant Ca²⁺ uptake into mitochondria, and mitochondrial recruitment of Drp1, resulting in mitochondrial fission. Inhibition of Drp1 or ER-mitochondrial Ca²⁺ signaling prevents p20-induced fission. p20 sensitizes mitochondria to caspase-8-induced cytochrome c release. Adenoviral expression of p20 BAP31 fragment; Ca²⁺ imaging; mitochondrial morphology assays; Drp1 dominant-negative inhibition; cytochrome c release assays The Journal of cell biology High 12668660
2003 Full-length BAP31, in association with the putative ER ion channel protein A4 (a constitutive BAP31-binding partner identified by split-ubiquitin yeast two-hybrid), is a direct inhibitor of BAX/BAK oligomerization and cytochrome c release downstream of caspase-8 activation, acting independently of its ability to generate p20. Split-ubiquitin yeast two-hybrid screen; co-immunoprecipitation; reconstitution in Bap31-null mouse cells; FKBPcasp8 inducible system; cytochrome c release assays The Journal of biological chemistry High 12529377
2003 BAP31 specifically associates with nonmuscle myosin heavy chain B and nonmuscle gamma-actin (components of the actomyosin cytoskeleton), and Fas-induced apoptosis releases these associations, potentially contributing to membrane remodelling during apoptosis. Capillary LC-MS/MS characterization of BAP31 immunocomplex from HepG2 cells; co-immunoprecipitation European journal of biochemistry Medium 12605685
2003 BAP29/BAP31 form high-molecular-weight complexes in the ER that retain membrane-bound IgD lacking its Ig-α/Ig-β subunits. In Drosophila S2 cells, surface appearance of IgD is prevented by coexpression of BAP29 and BAP31. The retention mechanism is true ER retention, not retrieval from a post-ER compartment. Blue native PAGE; co-immunoprecipitation; heterologous expression in Drosophila S2 cells; immunofluorescence Proceedings of the National Academy of Sciences of the United States of America Medium 12886015
2004 BAP31 specifically binds to CD11b/CD18 (beta-2 integrin) via the cytoplasmic tail of BAP31; the interaction is not dependent on divalent cations or the CD11b I-domain. BAP31 and CD11b/CD18 colocalize in neutrophil secondary granules and both redistribute to the plasma membrane upon fMLP stimulation. Monoclonal antibody co-precipitation; co-immunoprecipitation; GST-fusion binding assays; immunolocalization; subcellular fractionation The Journal of biological chemistry Medium 15294914
2004 BAP31 is required for stability of a novel ER integral membrane protein PTPLB; in Bap31-null mouse cells PTPLB turns over more rapidly via proteasomal degradation, whereas reconstitution with human BAP31 maintains PTPLB levels, consistent with a chaperone/quality control function for BAP31 in the ER membrane. Split-ubiquitin cDNA library screen; Bap31-null mouse cells reconstituted with BAP31; proteasome inhibitor experiments; turnover assays Molecular and cellular biology Medium 15024066
2005 BAP31 is required for cell-surface expression of tetraspanins CD9 and CD81; in Bap31-null mouse cells, CD9 and CD81 surface levels are reduced, integrin-mediated cell adhesion to extracellular matrix is impaired under serum stress, and cells are sensitized to apoptosis. Reconstitution of BAP31 restores surface tetraspanin levels and integrin-mediated survival. The p20 BAP31 cleavage product inhibits egress of tetraspanins and integrin-mediated cell attachment. Bap31-null mouse cells; reconstitution with wild-type BAP31; p20 BAP31 ectopic expression; flow cytometry for surface tetraspanins; adhesion and apoptosis assays; antibody antagonism of CD9/integrins The Journal of biological chemistry High 15946936
2005 BAP31 interacts with cytochrome P450 2C2 in the ER via transmembrane domain interactions (shown by bimolecular fluorescence complementation and Co-IP); BAP31 depletion causes redistribution of P450 2C2 from the ER to nuclear membrane and cell surface, and increases P450 2C2 expression levels, indicating BAP31 retains P450 2C2 in the ER. Bimolecular fluorescence complementation (BiFC); co-immunoprecipitation; siRNA knockdown of BAP31; Bap31-null ES cells reconstituted with BAP31; immunofluorescence The Journal of biological chemistry Medium 16332681
2006 BAP31 enhances ER export of peptide-loaded MHC class I molecules; overexpression of BAP31 increases surface class I levels by accelerating ER export and stabilizing exported molecules. BAP31 may also retrieve peptide-depleted class I from post-ER acidic compartments. Overexpression of the homolog BAP29 decreases surface class I levels. Transfection of YFP-Bap31 chimeras in HeLa cells; flow cytometry for surface MHC class I; pulse-chase experiments; comparison with BAP29 overexpression Journal of immunology Medium 17056546
2008 BAP31 is an itinerant ER protein that cycles between the peripheral ER and a juxtanuclear ER-related quality control compartment; this cycling depends on microtubules and dynein-dynactin function. The third and second transmembrane domains of BAP31 are principally responsible for movement to and recycling from the juxtanuclear region, respectively. Sar1p and Arf1 mutants affect BAP31 cycling. Live-cell fluorescence imaging with GFP-Bap31; FRAP; dominant-negative Sar1p and Arf1 mutants; microtubule depolymerization (nocodazole); dynein-dynactin disruption; transmembrane domain deletion mutants Molecular biology of the cell High 18287538
2008 BAP31 associates with two components of the Sec61 preprotein translocon (Sec61β and TRAM); BAP31 associates with the N-terminus of newly synthesized ΔF508-CFTR and promotes its retrotranslocation and degradation by the 26S proteasome. Depletion of BAP31 reduces proteasomal degradation of ΔF508 and allows it to reach the cell surface. BAP31 also physically and functionally associates with the Derlin-1 dislocation complex in the ΔF508 degradation pathway. Co-immunoprecipitation; siRNA depletion of BAP31; pulse-chase degradation assays; proteasome inhibition; cell-surface biotinylation; Derlin-1 association Cell High 18555783
2008 BAP31 interacts with HPV E5 proteins (HPV16 and HPV31); interaction confirmed by split-ubiquitin yeast two-hybrid and coimmunoprecipitation. Amino acids in the extreme C-terminus of E5 are required for stabilizing the interaction. Deletion of C-terminal E5 residues in complete HPV31 genomes impairs proliferative capacity of keratinocytes upon differentiation; siRNA knockdown of Bap31 similarly reduces this proliferative ability. Split-ubiquitin yeast two-hybrid screen; co-immunoprecipitation; E5 C-terminal deletion mutants in HPV31 genomes; siRNA knockdown of Bap31; colocalization (immunofluorescence) Journal of virology Medium 18684816
2009 BAP31 clusters with MHC class I (HLA-A2) in the ER and traffics with it to the ERGIC via export vesicles; FRET between BAP31 and HLA-A2 and forward traffic increase when class I molecules are loaded with peptide. Overexpression of BAP29 blocks BAP31-mediated forward traffic of class I. FRET (Förster resonance energy transfer); quantitative fluorescence microscopy; peptide pulse experiments; BAP29 overexpression Journal of immunology Medium 19342655
2010 Fis1 (outer mitochondrial membrane fission protein) interacts with BAP31 at the ER membrane to form the 'ARCosome' platform spanning the mitochondria-ER interface. This complex facilitates cleavage of BAP31 into pro-apoptotic p20BAP31. The BAP31 vDED domain is required for recruitment of procaspase-8 to the Fis1-BAP31 complex, and this recruitment is required for procaspase-8 activation. Activation triggers ER Ca²⁺ release establishing a feedback loop to activate mitochondria. Co-immunoprecipitation; Fis1 and BAP31 overexpression/knockdown; procaspase-8 recruitment assays; Ca²⁺ release measurements; BAP31 vDED domain mutants The EMBO journal High 21183955
2010 The yeast BAP31 homologs Yet1p and Yet3p form a complex (Yet complex) important for subunit stability and proper ER localization; the Yet complex is not efficiently packaged into COPII vesicles and is not an ER export receptor. Instead, a fraction of the Yet complex associates with the Sec61 ER translocation apparatus (Sec complex), and this association increases under ER stress and decreases when translocation substrates are depleted. Co-immunoprecipitation; COPII vesicle packaging assays; ER stress induction; genetic mutant analysis; protein stability assays in yeast The Journal of biological chemistry Medium 20378542
2011 BAP31 and the ER lumenal chaperone BiP are both required for dislocation of SV40 from the ER to the cytosol; both proteins colocalize with the virus in discrete foci. siRNA knockdown of BAP31 or BiP prevents ER-to-cytosol dislocation of SV40 particles. The ERAD machinery assists virus transport across the ER membrane. siRNA screen; immunofluorescence colocalization; SV40 infection and dislocation assays; siRNA knockdown functional validation Nature cell biology High 21947079
2013 CDIP1 (a proapoptotic p53 target) interacts with BAP31 at the ER membrane; upon ER stress CDIP1 is induced and enhances its association with BAP31. CDIP1 binding to BAP31 is required for BAP31 cleavage during ER stress and for BAP31-Bcl-2 association. The CDIP1-BAP31 complex recruits Bcl-2, promotes tBid and caspase-8 activation, and BAX oligomerization. CDIP1 knockout in mice impairs ER-stress-mediated apoptosis. Co-immunoprecipitation; ER stress induction; CDIP1 knockout mice; BAP31 cleavage assays; caspase-8 activation assays; BAX oligomerization Cell reports High 24139803
2013 Loss-of-function mutations in BCAP31 in humans result in ER morphology alteration and Golgi disorganization in primary fibroblasts, demonstrating that BAP31 is required for ER-to-Golgi crosstalk. Constitutive BCAP31 deficiency does not activate the unfolded protein response or cell-death effectors (in contrast to transient RNAi experiments). Patient-derived primary fibroblasts with loss-of-function BCAP31 mutations; immunofluorescence for ER/Golgi morphology; UPR marker assays; Western blot for cell-death effectors American journal of human genetics Medium 24011989
2013 The cytoplasmic variant of death effector domain (vDED) of BAP31 forms a dimeric parallel coiled coil (crystal structure determined), with no structural similarity to canonical DED domains. Solution studies confirm this coiled-coil conformation and suggest an additional C-terminal alpha-helical coiled-coil domain. BAP29 vDED is partially unfolded at neutral pH in vitro. X-ray crystallography (two crystal forms); circular dichroism; size-exclusion chromatography; solution biophysical characterization PloS one High 23967155
2015 BAP31 directly interacts with the RSV small hydrophobic (SH) protein; the C-terminal endodomain of BAP31 and SH protein interact directly as shown by NMR titration of purified proteins in detergent micelles, and SH protein pulls down endogenous BAP31. Membrane-based yeast two-hybrid; co-immunoprecipitation (pull-down); NMR titration of purified proteins Virology Medium 25854864
2015 BAP31 on the cell surface of human embryonic stem cells exposes its C-terminal domain extracellularly, representing a novel membrane topology distinct from its canonical ER orientation (where C-terminus faces cytosol). Epitope mapping with deletion mutants confirmed that both cytoplasm-facing and surface-exposed C-terminal residues 208–217 are recognized by antibodies. Monoclonal antibody epitope mapping; GST-fused BAP31 serial C-terminal deletion mutants; immunofluorescence on hESCs and mESCs PloS one Low 26102500
2017 BAP31 is required for T cell activation through TCR signaling; BAP31 conditional knockdown in mouse thymus reduces T cell numbers and proliferation, decreases phosphorylation of ZAP70, Lck, Lat (upstream TCR), and Akt, GSK, JNK, ERK (downstream), and reduces TCRα/β/CD3 expression and cytokines (IL-2, IFN-γ, IL-6, TNF-α). Conditional BAP31 knockdown mouse (Cre/loxP); T cell proliferation assays; Western blot for phosphorylated TCR signaling components; flow cytometry for surface markers; ELISA for cytokines Scientific reports Medium 28333124
2018 BAP31 is a binding partner of RTN3 and positively regulates RTN3 monomer stability; BAP31 knockout in hippocampal neurons increases RTN3 aggregate formation and decreases RTN3 monomer availability, enhancing BACE1-mediated APP processing and amyloid-β plaque deposition in an Alzheimer's disease mouse model. Co-immunoprecipitation; conditional BAP31 KO mice crossed with APP/PS1 AD model mice; Western blot for RTN3 monomer vs. aggregates; BACE1 activity; amyloid plaque quantification FASEB journal Medium 30596517
2017 Hepatocyte-specific deletion of BAP31 increases SREBP1C expression and activity; immunoprecipitation shows BAP31 interacts with SREBP1C and INSIG1; BAP31 deletion reduces INSIG1 expression, suggesting BAP31 regulates SREBP1C activity by modulating INSIG1 levels, leading to increased hepatic lipid accumulation and ER stress. Hepatocyte-specific conditional BAP31 KO mice; high-fat diet challenge; co-immunoprecipitation; Western blot for SREBP1C targets; hepatic lipid assays; ER stress markers Journal of lipid research Medium 29113994
2019 BAP31 interacts with the mitochondrial import protein Tom40 within ER-mitochondria contact sites; the BAP31-Tom40 complex facilitates translocation of NDUFS4 (a complex I subunit) from the cytosol to mitochondria. Disruption of the BAP31-Tom40 complex inhibits mitochondrial complex I activity and oxygen consumption. Co-immunoprecipitation; NDUFS4 translocation assays; mitochondrial complex I activity assays; oxygen consumption measurements; BAP31 knockdown Science advances High 31206022
2019 BAP31 inhibits autophagy by forming a BAP31-STX17 protein complex; loss of BAP31 stimulates tumor growth under metabolic stress conditions in vivo and enhances invasion activity. BAP31 acts to suppress ER stress adaptation and suppress autophagy. Co-immunoprecipitation of BAP31-STX17 complex; BAP31 KO cells; autophagy assays; xenograft tumor models; invasion assays Cells Medium 31671609
2019 BCAP31 interacts with EGFR and acts as an inhibitor of ligand-independent EGFR recycling, sustaining EGFR autophosphorylation and activation of downstream signaling. BCAP31 knockdown reduces TNBC tumor growth. Co-immunoprecipitation; EGFR recycling/trafficking assays; phosphorylation assays; BCAP31 knockdown in vitro and in vivo Theranostics Medium 31588230
2019 BAP31 specifically interacts with and regulates the proteasomal degradation of p27kip1 (cyclin kinase inhibitor); an intrabody (VH-D1) against BAP31 inhibits p27kip1 proteasome degradation, possibly by blocking BAP31-p27kip1 interaction, leading to suppressed proliferation and increased apoptosis in gastric cancer cells. Co-immunoprecipitation; intrabody expression; proteasome inhibitor assays; cell proliferation and apoptosis assays; xenograft mouse model International journal of cancer Medium 30338855
2019 BAP31 deficiency in microglia upregulates IRAK1 protein levels, which in turn increases NF-κB p65 and c-Jun nuclear translocation and transcriptional activity, enhancing LPS-induced proinflammatory cytokine production. Knockdown of IRAK1 or an IRAK1 inhibitor reverses these effects. BAP31 conditional knockdown mice; BV2 cell knockdown; Western blot for IRAK1, phospho-NF-κB, phospho-c-Jun; ELISA for cytokines; immunofluorescence for NF-κB translocation; LPS-induced cognitive impairment model Journal of neuroinflammation Medium 31883536
2020 BAP31 directly binds to SERPINE2 (serpin family E member 2); co-immunoprecipitation and immunofluorescence assays confirm the interaction; BAP31 promotes HCC tumor cell proliferation by stabilizing SERPINE2 and activating downstream Erk1/2 and p38 phosphorylation. Co-immunoprecipitation; immunofluorescence; RNA-seq; BAP31 knockdown/overexpression; tumor xenografts Frontiers in cell and developmental biology Medium 33363167
2023 BAP31 interacts with VDAC1 at the ER-mitochondria interface and affects VDAC1 oligomerization and polyubiquitination; knockdown of BAP31 increases lipid peroxidation and promotes ferroptosis and G1/S arrest in gastric cancer. HNF4A binds the BAP31 promoter and increases its transcription. Co-immunoprecipitation; VDAC1 oligomerization assays; ubiquitination assays; ChIP for HNF4A at BAP31 promoter; BAP31 knockdown; ferroptosis assays Cell death & disease Medium 37296105
2023 BAP31 interacts with Perilipin1 via its C-terminal cytoplasmic domain on the surface of lipid droplets; BAP31 depletion represses Perilipin1 proteasomal degradation, leading to enhanced Perilipin1 expression, blocked lipid droplet degradation, supersized lipid droplet formation, impaired lipolysis, and altered adipogenesis. Co-immunoprecipitation; BAP31-adipocyte-specific KO mice; adipocyte differentiation of MEFs; lipolysis assays; proteasome inhibitor experiments; lipid droplet imaging International journal of biological sciences Medium 37063427
2025 Sirtuin 2 deacetylates BAP31 specifically at lysine 158 (K158); this deacetylation stabilizes BAP31 expression. Loss of sirtuin 2 reduces BAP31 expression. Carnosol upregulates sirtuin 2, which in turn deacetylates BAP31 to attenuate ER stress and hepatocyte apoptosis in alcoholic liver disease. Sirtuin 2 knockdown; site-specific acetylation mapping at K158; Western blot; alcohol-induced liver injury mouse model British journal of pharmacology Medium 39887347
2025 Crystal structure of the Fis1 cytosolic domain bound to the C-terminal vDED region of BAP31 reveals that the Bap31_vDED region engages the convex surface of Fis1's tetratricopeptide repeat (TPR) domain. One Fis1 structure features an N-terminal 'Fis1 arm' conformation suggestive of an autoinhibitory function. X-ray crystallography of Fis1 alone (two conformations) and Fis1-Bap31_vDED co-complex Communications biology High 40770055
2025 PINK1 interacts with BAP31 and phosphorylates it at serine 142 (Ser142). PINK1-mediated phosphorylation of BAP31 is required for its neuroprotective effects against ER stress-mediated apoptosis; phosphomimetic BAP31-S142E strengthens protection while phospho-dead BAP31-S142A abolishes it. Co-immunoprecipitation; site-directed mutagenesis (S142A, S142E phosphomimetics); ER stress assays; PINK1 overexpression/knockdown; in vitro and in vivo neuronal models Cell death & disease Medium 41022756
2024 BCAP31 directly interacts with PINK1 and promotes PINK1 phosphorylation; BAP31 depletion reduces phosphorylated PINK1 levels, thereby inhibiting PINK1/Parkin-mediated mitophagy, leading to increased mitochondrial ROS, NF-κB activation, and alveolar epithelial cell apoptosis in acute lung injury. Co-immunoprecipitation (BAP31-PINK1); BCAP31 transgenic and conditional KO mice; mitophagy assays; mitochondrial ROS measurement; LPS-induced ALI model Research (Washington, D.C.) Medium 39381793
2024 BAP31 is exploited by Legionella pneumophila; a Legionella effector Lpg1152 binds to BAP31. BAP31 together with Rab10 and Rab4 GTPases facilitates transitioning the Legionella-containing vacuole (LCV) from smooth ER to rough ER association. Optimal Legionella growth requires both BAP31 and Lpg1152. Co-immunoprecipitation of Lpg1152 with BAP31; BAP31 knockdown; Rab10/Rab4 knockdown; LCV morphology imaging; bacterial growth assays Cell reports Medium 39661521
2022 BAP31 regulates ICAM-1 and VCAM-1 expression in endothelial cells via the MyD88/TRAF6-TAK1/NF-κB and PI3K/Akt signaling cascades; BAP31 knockdown deactivates these cascades, reducing NF-κB nuclear translocation and reducing neutrophil-endothelial cell adhesion in ALI. shBAP31 endothelial cell lines; endothelial-specific conditional BAP31 KO mice; luciferase reporter assays for ICAM-1/VCAM-1 promoters; ChIP; intravital microscopy; Western blot for NF-κB pathway proteins Life sciences Medium 36549351
2023 BAP31 promotes N-glycosylation of EpCAM by affecting the Sec61 translocation channel; the amino acid region 165-205 of BAP31 is important for this function. An intrabody (VH-F12) against this region inhibits EpCAM glycosylation. EpCAM glycosylation mutants (N76/111/198A); BAP31 C-terminal deletion constructs; intrabody expression; Western blot; Co-immunoprecipitation with Sec61 International journal of molecular sciences Medium 37834237
2025 BAP31 interacts with ELAVL1 (an RNA-binding protein) and promotes its maturation; ELAVL1 binds to the 3'UTR of SPINK6 mRNA to stabilize its expression. BAP31 silencing inhibits HCC cell invasion/migration and recovers cell polarity via reduction of SPINK6. IP-MS (immunoprecipitation mass spectrometry); immunofluorescence; RNA immunoprecipitation (RIP); RNA-FISH; RNA stability assays; luciferase reporter assay; in vivo metastasis model International journal of biological sciences Medium 39990675
2025 BAP31 interacts with PCMT1, a direct negative regulator of MST1 kinase; BAP31 knockdown activates MST1 and inhibits YAP transcription factor, suppressing breast cancer stemness via the Hippo pathway. Co-immunoprecipitation (BAP31-PCMT1); BAP31 knockdown; MST1 activity and YAP phosphorylation assays; tumor sphere formation; xenograft models International journal of molecular sciences Low 40332113

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2003 Caspase cleavage product of BAP31 induces mitochondrial fission through endoplasmic reticulum calcium signals, enhancing cytochrome c release to the cytosol. The Journal of cell biology 452 12668660
2010 Fis1 and Bap31 bridge the mitochondria-ER interface to establish a platform for apoptosis induction. The EMBO journal 434 21183955
1997 p28 Bap31, a Bcl-2/Bcl-XL- and procaspase-8-associated protein in the endoplasmic reticulum. The Journal of cell biology 283 9334338
2005 Accumulation of mutant alpha1-antitrypsin Z in the endoplasmic reticulum activates caspases-4 and -12, NFkappaB, and BAP31 but not the unfolded protein response. The Journal of biological chemistry 192 16183649
1998 Rapid cytochrome c release, activation of caspases 3, 6, 7 and 8 followed by Bap31 cleavage in HeLa cells treated with photodynamic therapy. FEBS letters 145 9804161
2004 Association of active caspase 8 with the mitochondrial membrane during apoptosis: potential roles in cleaving BAP31 and caspase 3 and mediating mitochondrion-endoplasmic reticulum cross talk in etoposide-induced cell death. Molecular and cellular biology 142 15254227
2011 BAP31 and BiP are essential for dislocation of SV40 from the endoplasmic reticulum to the cytosol. Nature cell biology 137 21947079
1997 Export of cellubrevin from the endoplasmic reticulum is controlled by BAP31. The Journal of cell biology 136 9396746
2008 BAP31 interacts with Sec61 translocons and promotes retrotranslocation of CFTRDeltaF508 via the derlin-1 complex. Cell 132 18555783
2019 BAP31 regulates mitochondrial function via interaction with Tom40 within ER-mitochondria contact sites. Science advances 119 31206022
2002 The procaspase-8 isoform, procaspase-8L, recruited to the BAP31 complex at the endoplasmic reticulum. Proceedings of the National Academy of Sciences of the United States of America 106 11917123
2000 Caspase-resistant BAP31 inhibits fas-mediated apoptotic membrane fragmentation and release of cytochrome c from mitochondria. Molecular and cellular biology 102 10958671
2008 Bap31 is an itinerant protein that moves between the peripheral endoplasmic reticulum (ER) and a juxtanuclear compartment related to ER-associated Degradation. Molecular biology of the cell 101 18287538
1996 The specificity of association of the IgD molecule with the accessory proteins BAP31/BAP29 lies in the IgD transmembrane sequence. The EMBO journal 92 8612576
2019 MiR-451a suppressing BAP31 can inhibit proliferation and increase apoptosis through inducing ER stress in colorectal cancer. Cell death & disease 84 30770794
2013 CDIP1-BAP31 complex transduces apoptotic signals from endoplasmic reticulum to mitochondria under endoplasmic reticulum stress. Cell reports 83 24139803
1998 Bcl-XL cooperatively associates with the Bap31 complex in the endoplasmic reticulum, dependent on procaspase-8 and Ced-4 adaptor. The Journal of biological chemistry 79 9452422
2019 Melatonin attenuates ER stress and mitochondrial damage in septic cardiomyopathy: A new mechanism involving BAP31 upregulation and MAPK-ERK pathway. Journal of cellular physiology 76 31535369
2003 A high-molecular-weight complex of membrane proteins BAP29/BAP31 is involved in the retention of membrane-bound IgD in the endoplasmic reticulum. Proceedings of the National Academy of Sciences of the United States of America 74 12886015
2010 Membrane-Associated RING-CH proteins associate with Bap31 and target CD81 and CD44 to lysosomes. PloS one 67 21151997
2008 Bap31 is a novel target of the human papillomavirus E5 protein. Journal of virology 67 18684816
2013 Mutations in BCAP31 cause a severe X-linked phenotype with deafness, dystonia, and central hypomyelination and disorganize the Golgi apparatus. American journal of human genetics 56 24011989
2003 Uncleaved BAP31 in association with A4 protein at the endoplasmic reticulum is an inhibitor of Fas-initiated release of cytochrome c from mitochondria. The Journal of biological chemistry 56 12529377
2018 BAP31, a newly defined cancer/testis antigen, regulates proliferation, migration, and invasion to promote cervical cancer progression. Cell death & disease 54 30022068
2006 Bap31 enhances the endoplasmic reticulum export and quality control of human class I MHC molecules. Journal of immunology (Baltimore, Md. : 1950) 53 17056546
2004 Association of BAP31 with CD11b/CD18. Potential role in intracellular trafficking of CD11b/CD18 in neutrophils. The Journal of biological chemistry 52 15294914
2001 Control of cystic fibrosis transmembrane conductance regulator expression by BAP31. The Journal of biological chemistry 50 11274174
2004 The yeast split-ubiquitin membrane protein two-hybrid screen identifies BAP31 as a regulator of the turnover of endoplasmic reticulum-associated protein tyrosine phosphatase-like B. Molecular and cellular biology 48 15024066
2023 HNF4A-BAP31-VDAC1 axis synchronously regulates cell proliferation and ferroptosis in gastric cancer. Cell death & disease 47 37296105
2002 Contiguous deletion of the X-linked adrenoleukodystrophy gene (ABCD1) and DXS1357E: a novel neonatal phenotype similar to peroxisomal biogenesis disorders. American journal of human genetics 47 11992258
2021 BAP31: Physiological functions and roles in disease. Biochimie 46 33930507
2005 BAP31 and its caspase cleavage product regulate cell surface expression of tetraspanins and integrin-mediated cell survival. The Journal of biological chemistry 44 15946936
2017 BAP31 is involved in T cell activation through TCR signal pathways. Scientific reports 42 28333124
2011 Fis1, Bap31 and the kiss of death between mitochondria and endoplasmic reticulum. The EMBO journal 42 21285974
2005 BAP31 is involved in the retention of cytochrome P450 2C2 in the endoplasmic reticulum. The Journal of biological chemistry 41 16332681
2019 A BAP31 intrabody induces gastric cancer cell death by inhibiting p27kip1 proteasome degradation. International journal of cancer 40 30338855
2009 Interaction of Bap31 and MHC class I molecules and their traffic out of the endoplasmic reticulum. Journal of immunology (Baltimore, Md. : 1950) 40 19342655
2020 Pirfenidone alleviates lipopolysaccharide-induced lung injury by accentuating BAP31 regulation of ER stress and mitochondrial injury. Journal of autoimmunity 39 32381456
2019 BAP31 regulates IRAK1-dependent neuroinflammation in microglia. Journal of neuroinflammation 38 31883536
2020 MiR-362 suppresses cervical cancer progression via directly targeting BAP31 and activating TGFβ/Smad pathway. Cancer medicine 33 33210473
2012 Contiguous deletion of SLC6A8 and BAP31 in a patient with severe dystonia and sensorineural deafness. Molecular genetics and metabolism 33 22472424
2020 BAP31 Promotes Tumor Cell Proliferation by Stabilizing SERPINE2 in Hepatocellular Carcinoma. Frontiers in cell and developmental biology 32 33363167
2018 BAP31 deficiency contributes to the formation of amyloid-β plaques in Alzheimer's disease by reducing the stability of RTN3. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 32 30596517
2017 Hepatocyte-specific deletion of BAP31 promotes SREBP1C activation, promotes hepatic lipid accumulation, and worsens IR in mice. Journal of lipid research 29 29113994
2014 Genotype-phenotype correlation of contiguous gene deletions of SLC6A8, BCAP31 and ABCD1. Clinical genetics 28 24597975
2003 The resident endoplasmic reticulum protein, BAP31, associates with gamma-actin and myosin B heavy chain. European journal of biochemistry 27 12605685
2018 Induction of Liver Steatosis in BAP31-Deficient Mice Burdened with Tunicamycin-Induced Endoplasmic Reticulum Stress. International journal of molecular sciences 26 30081561
2010 Yet1p and Yet3p, the yeast homologs of BAP29 and BAP31, interact with the endoplasmic reticulum translocation apparatus and are required for inositol prototrophy. The Journal of biological chemistry 26 20378542
2001 Endoplasmic reticulum membrane-sorting protein of lymphocytes (BAP31) is highly expressed in neurons and discrete endocrine cells. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 26 11561007
2019 BCAP31 drives TNBC development by modulating ligand-independent EGFR trafficking and spontaneous EGFR phosphorylation. Theranostics 25 31588230
1994 A new human gene (DXS1357E) with ubiquitous expression, located in Xq28 adjacent to the adrenoleukodystrophy gene. Genomics 25 7806238
2019 BAP31 Inhibits Cell Adaptation to ER Stress Conditions, Negatively Regulating Autophagy Induction by Interaction with STX17. Cells 23 31671609
2012 Contiguous ABCD1 DXS1357E deletion syndrome: report of an autopsy case. Neuropathology : official journal of the Japanese Society of Neuropathology 23 22994209
2015 BAP31, a promising target for the immunotherapy of malignant melanomas. Journal of experimental & clinical cancer research : CR 22 25903101
2018 Inhibition of BAP31 expression inhibits cervical cancer progression by suppressing metastasis and inducing intrinsic and extrinsic apoptosis. Biochemical and biophysical research communications 21 30503502
2022 Lanthanum decreased VAPB-PTPP51, BAP31-FIS1, and MFN2-MFN1 expression of mitochondria-associated membranes and induced abnormal autophagy in rat hippocampus. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20 35090998
2022 BAP31 regulates the expression of ICAM-1/VCAM-1 via MyD88/NF-κB pathway in acute lung injury mice model. Life sciences 20 36549351
2020 MicroRNA-362-3p Inhibits Migration and Invasion via Targeting BCAP31 in Cervical Cancer. Frontiers in molecular biosciences 20 32582765
2000 Limited caspase cleavage of human BAP31. FEBS letters 20 11078879
2020 BCAP31, a cancer/testis antigen-like protein, can act as a probe for non-small-cell lung cancer metastasis. Scientific reports 19 32132574
2014 Distal Xq28 microdeletions: clarification of the spectrum of contiguous gene deletions involving ABCD1, BCAP31, and SLC6A8 with a new case and review of the literature. American journal of medical genetics. Part A 19 25044748
2013 Structural and biophysical characterization of the cytoplasmic domains of human BAP29 and BAP31. PloS one 19 23967155
2023 The BAP31/miR-181a-5p/RECK axis promotes angiogenesis in colorectal cancer via fibroblast activation. Frontiers in oncology 15 36895489
2015 Interaction between human BAP31 and respiratory syncytial virus small hydrophobic (SH) protein. Virology 15 25854864
2017 BCAP31-associated encephalopathy and complex movement disorder mimicking mitochondrial encephalopathy. American journal of medical genetics. Part A 14 28332767
2024 BCAP31 Alleviates Lipopolysaccharide-Mediated Acute Lung Injury via Induction of PINK1/Parkin in Alveolar Epithelial Type II Cell. Research (Washington, D.C.) 13 39381793
2023 BAP31 depletion inhibited adipogenesis, repressed lipolysis and promoted lipid droplets abnormal growth via attenuating Perilipin1 proteasomal degradation. International journal of biological sciences 12 37063427
2020 Possible mitochondrial dysfunction in a patient with deafness, dystonia, and cerebral hypomyelination (DDCH) due to BCAP31 Mutation. Molecular genetics & genomic medicine 12 31953925
2019 BCAP31-related syndrome: The first de novo report. European journal of medical genetics 12 31330203
2021 Further delineation of BCAP31-linked intellectual disability: description of 17 new families with LoF and missense variants. European journal of human genetics : EJHG 10 33603160
2015 Epitope Mapping of Antibodies Suggests the Novel Membrane Topology of B-Cell Receptor Associated Protein 31 on the Cell Surface of Embryonic Stem Cells: The Novel Membrane Topology of BAP31. PloS one 10 26102500
2022 BAP31 Promotes Proliferation, Invasion, and Metastasis of Liver Cancer Cells via Activating PI3K/AKT Pathway. Journal of healthcare engineering 9 35449837
2020 De novo mutation and skewed X-inactivation in girl with BCAP31-related syndrome. Human mutation 9 32652807
2016 Plant-specific 4/1 polypeptide interacts with an endoplasmic reticulum protein related to human BAP31. Planta 9 27714454
2022 BAP31 Regulates Wnt Signaling to Modulate Cell Migration in Lung Cancer. Frontiers in oncology 8 35359416
2021 Regulation of Superoxide by BAP31 through Its Effect on p22phox and Keap1/Nrf2/HO-1 Signaling Pathway in Microglia. Oxidative medicine and cellular longevity 8 33777312
2022 BAP31 affects macrophage polarization through regulating helper T cells activation. Journal of molecular histology 7 36018529
2020 Schimke XLID syndrome results from a deletion in BCAP31. American journal of medical genetics. Part A 7 32681719
2025 Deacetylation of BAP31 by sirtuin 2 attenuates apoptosis of hepatocytes induced by endoplasmic reticulum stress, in chronic alcoholic liver injury. British journal of pharmacology 6 39887347
2024 BAP31 Promotes Adhesion Between Endothelial Cells and Macrophages Through the NF-κB Signaling Pathway in Sepsis. Journal of inflammation research 6 38434584
2024 BAP31 Promotes Angiogenesis via Galectin-3 Upregulation in Neuroblastoma. International journal of molecular sciences 6 38474195
2023 Knockdown of BAP31 Downregulates Galectin-3 to Inhibit the Wnt/β-Catenin Signaling Pathway to Modulate 5-FU Chemosensitivity and Cancer Stemness in Colorectal Cancer. International journal of molecular sciences 6 37762705
2023 BAP31-Mediated miR-206/133b Cluster Promotes Transendothelial Migration and Metastasis of Colorectal Cancer. International journal of molecular sciences 6 38069061
2009 Novel immunohistochemical monoclonal antibody against rat B cell receptor Associated Protein 31 (BAP31). Hybridoma (2005) 6 19857118
2023 BAP31 Knockout in Macrophages Affects CD4+T Cell Activation through Upregulation of MHC Class II Molecule. International journal of molecular sciences 5 37686286
2022 BCAP31 is involved in modulating colorectal cancer cell proliferation via the Emerin/β-catenin axis. Experimental cell research 5 35716785
2007 Preliminary structural studies on the leucine-zipper homology region of the human protein Bap31. Acta crystallographica. Section F, Structural biology and crystallization communications 5 17401199
2025 BAP31-ELAVL1-SPINK6 axis induces loss of cell polarity and promotes metastasis in hepatocellular carcinoma. International journal of biological sciences 3 39990675
2025 BAP31 represses endoplasmic reticulum stress-mediated apoptosis and alleviates neurodegeneration in Parkinson's disease. Cell death & disease 3 41022756
2024 NDC1 promotes hepatocellular carcinoma tumorigenesis by targeting BCAP31 to activate PI3K/AKT signaling. Journal of biochemical and molecular toxicology 3 38348718
2023 Knockdown of BAP31 Overcomes Hepatocellular Carcinoma Doxorubicin Resistance through Downregulation of Survivin. International journal of molecular sciences 3 37108785
2021 Hepatocyte-Specific Deficiency of BAP31 Amplified Acetaminophen-Induced Hepatotoxicity via Attenuating Nrf2 Signaling Activation in Mice. International journal of molecular sciences 3 34639126
2009 Monoclonal antibodies against human BAP31 for immunocytochemistry. Hybridoma (2005) 3 19519245
2025 An X-Linked Ataxia Syndrome in a Family with Hearing Loss Associated with a Novel Variant in the BCAP31 Gene. Movement disorders : official journal of the Movement Disorder Society 2 39831730
2025 BAP31 Promotes Epithelial-Mesenchymal Transition Progression Through the Exosomal miR-423-3p/Bim Axis in Colorectal Cancer. International journal of molecular sciences 2 40564945
2025 BCAP31 promotes colorectal cancer metastasis via oxidative phosphorylation-dependent macrophage immunosuppression: A single-cell transcriptomic study. Free radical biology & medicine 2 40769312
2025 Crystal structure of Fis1 and Bap31 provides information on protein-protein interactions at mitochondria-associated ER membranes. Communications biology 2 40770055
2023 An Intrabody against B-Cell Receptor-Associated Protein 31 (BAP31) Suppresses the Glycosylation of the Epithelial Cell-Adhesion Molecule (EpCAM) via Affecting the Formation of the Sec61-Translocon-Associated Protein (TRAP) Complex. International journal of molecular sciences 2 37834237
2025 Knockdown of BAP31 Suppresses Tumorigenesis and Stemness in Breast Cancer Cells via the Hippo Pathway. International journal of molecular sciences 1 40332113
2024 Legionella uses host Rab GTPases and BAP31 to create a unique ER niche. Cell reports 1 39661521

Missed literature

Know a paper Affinage missed for BCAP31? Flag it for the maintainers and the community.

No submissions yet.