Affinage

ARF4

ADP-ribosylation factor 4 · UniProt P18085

Length
180 aa
Mass
20.5 kDa
Annotated
2026-06-09
40 papers in source corpus 18 papers cited in narrative 18 extracted findings
Cross-family judge vs UniProt: tie faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

ARF4 is a small Ras-family GTPase that regulates multiple membrane trafficking pathways across the secretory and endosomal systems (PMID:8668142, PMID:24185178). At the trans-Golgi network it directly binds the VxPx C-terminal sorting motif of rhodopsin to generate post-Golgi carriers destined for the photoreceptor outer segment/cilium (PMID:15728366), and it nucleates a ciliary targeting complex in which the Arf GAP ASAP1 acts as both effector and scaffold, stimulating GTP hydrolysis on ARF4 and bridging Rab11/FIP3 and Rab8 (via Rabin8) to package cargo into budding carriers (PMID:19153612, PMID:22983554). ARF4 activation at the Golgi is driven by the GEF GBF1, which forms a GBF1–ARF4–rhodopsin complex that provides positive feedback for ciliary trafficking (PMID:29025970), and ARF4 similarly recognizes the ciliary targeting signals of fibrocystin and Presenilin-2 to control their delivery to the cilium/basal body and downstream Notch-dependent epidermal differentiation (PMID:24586199, PMID:27354375). Beyond cilia, ARF4 acts redundantly with other Arf isoforms: with ARF1 it maintains recycling-endosome morphology and supports retrograde transport from early/recycling endosomes to the TGN (PMID:23783033), and with ARF1 and ARF5 it is jointly required for ER export of receptor tyrosine kinases (PMID:38679330). ARF4 is transcriptionally induced as part of a CREB3–ARF4 Golgi stress response that buffers Golgi integrity and trafficking against disruption (PMID:24185178), is stabilized against K48-linked ubiquitination by the deubiquitinase USP7 (PMID:34556124), and supports diverse physiological and pathological processes including dendritic spine and cortical-neuron migration via N-cadherin trafficking (PMID:23050017, PMID:37848288), intestinal epithelial barrier permeability (PMID:28760826), nuclear EGFR retrograde signaling and chemoresistance in glioblastoma (PMID:38506351), and Golgi-dependent egress of multiple RNA viruses (PMID:39972062). Tissue-specific knockouts show ARF4 is dispensable for ciliary trafficking in rod photoreceptors and kidney but essential for pancreatic exocrine endomembrane function and embryonic viability (PMID:28410364, PMID:24586199).

Mechanistic history

Synthesis pass · year-by-year structured walk · 17 steps
  1. 2005 Medium

    Established ARF4 as a functional component of the secretory/vesicle-coat machinery by showing it can substitute in the Sec7-dependent secretory pathway.

    Evidence Human cDNA suppression of conditional-lethal yeast sec7 mutants with complementation and fractionation assays

    PMID:8668142

    Open questions at the time
    • Cross-species complementation does not define the native human substrate or carrier
    • Does not localize the relevant trafficking step
  2. 2005 High

    Identified ARF4 as a direct reader of a cargo sorting motif, linking it specifically to ciliary/outer-segment receptor trafficking.

    Evidence Rhodopsin C-terminal VxPx peptide pulldown plus dominant-negative ARF4 block and budding assays in frog retina

    PMID:15728366

    Open questions at the time
    • Did not define the full carrier-assembly machinery
    • GEF/GAP regulation of ARF4 in this step unknown at the time
  3. 2009 High

    Defined the ciliary targeting complex and its GAP, showing ASAP1-mediated GTP hydrolysis on ARF4 is required for productive carrier budding.

    Evidence Co-IP, in vitro GTP hydrolysis assay with the ARF4-I46D mutant, and transgenic frog with retinal-degeneration readout

    PMID:19153612

    Open questions at the time
    • How ASAP1 spatially couples hydrolysis to budding not resolved
    • Generalizability beyond rhodopsin unclear at the time
  4. 2012 High

    Extended the complex to a Rab cascade, positioning ASAP1 as a scaffold coordinating ARF4, Rab11 and Rab8 for ciliary cargo delivery.

    Evidence siRNA knockdown, reciprocal Co-IP and rhodopsin trafficking assays

    PMID:22983554

    Open questions at the time
    • Order of complex assembly not fully kinetically resolved
    • Signal recognition split between ARF4 (VxPx) and ASAP1 (FR) not mechanistically integrated
  5. 2012 Medium

    Connected ARF4 GTPase activity to neuronal synaptic structure, an output distinct from cilia.

    Evidence Arf4(+/-) mice, neuronal shRNA and GTPase-mutant overexpression, mEPSC recording and behavioral assay

    PMID:23050017

    Open questions at the time
    • Cargo carried by ARF4 in spines not identified
    • Single lab, mechanism downstream of ASAP1 antagonism unclear
  6. 2013 Medium

    Revealed an Arf-redundant role in endosomal recycling and retrograde transport, separating ARF4 function from the classic Golgi-only view.

    Evidence Single and double ARF1/ARF4 siRNA depletion with cargo-specific transport assays

    PMID:23783033

    Open questions at the time
    • Molecular basis of ARF1/ARF4 redundancy not defined
    • Effectors at recycling endosomes not identified
  7. 2013 High

    Placed ARF4 in a stress-response circuit, showing CREB3-driven ARF4 induction protects Golgi integrity and trafficking, with GBF1/ARF1/ARF5 dependence.

    Evidence Genome-wide haploid genetic screen, siRNA validation, Golgi morphology and gene-expression analyses

    PMID:24185178

    Open questions at the time
    • Direct transcriptional mechanism of CREB3 on ARF4 not detailed
    • Stress-sensing trigger upstream of CREB3 unresolved
  8. 2014 Medium

    Generalized ARF4 cargo recognition to a second ciliary receptor and exposed essential developmental functions via knockout.

    Evidence Arf4-fibrocystin CTS binding assay, pulse-chase trafficking, and conditional/global knockout mice

    PMID:24586199

    Open questions at the time
    • Only delivery kinetics, not steady-state levels, affected — significance unclear
    • Embryonic lethality limits adult-tissue analysis
  9. 2016 Medium

    Linked ARF4-dependent ciliary targeting (Presenilin-2 via VxPx) to Notch signaling and tissue differentiation.

    Evidence siRNA, VxPx-motif mutagenesis, immunofluorescence and epidermal differentiation assays

    PMID:27354375

    Open questions at the time
    • Direct ARF4-Presenilin binding not demonstrated
    • Single lab
  10. 2017 High

    Resolved the activation logic by showing GBF1 activates ARF4 in a cargo-coupled GBF1-ARF4-rhodopsin feedback complex.

    Evidence Co-IP with recombinant human proteins in frog retina, Golgicide A inhibition, pulse-chase trafficking

    PMID:29025970

    Open questions at the time
    • Stoichiometry and structure of the GBF1-ARF4-cargo complex unknown
    • How feedback is terminated unresolved
  11. 2017 High

    Challenged the obligatory ciliary-trafficking model by showing tissue-specific dispensability in retina and kidney while revealing an essential pancreatic role.

    Evidence Conditional and global knockout mice with retinal localization and histology

    PMID:28410364

    Open questions at the time
    • Source of tissue-specificity (Arf isoform redundancy) not defined
    • Pancreatic cargo dependency uncharacterized
  12. 2017 Medium

    Embedded ARF4 in a miRNA-controlled pathway regulating intestinal epithelial barrier permeability.

    Evidence miR-21-5p overexpression, ARF4/PTEN/PDCD4 RNAi, tight-junction and permeability assays in Caco-2 and mouse intestine

    PMID:28760826

    Open questions at the time
    • Trafficking step controlling tight junctions not identified
    • Direct ARF4 effectors in this context unknown
  13. 2021 Medium

    Identified post-translational control of ARF4 abundance through USP7-mediated deubiquitination, linking ARF4 stability to cancer cell survival.

    Evidence Co-IP, TMT proteomics, ubiquitination/apoptosis assays and intracranial xenografts

    PMID:34556124

    Open questions at the time
    • E3 ligase opposing USP7 on ARF4 not identified
    • Anti-apoptotic mechanism downstream of ARF4 not defined
  14. 2023 Medium

    Tied ARF4 to cortical neuron radial migration through N-cadherin trafficking, with cargo-supplementation rescue establishing causality.

    Evidence In utero electroporation shRNA, N-cadherin/Golgi imaging, time-lapse migration and N-cadherin rescue

    PMID:37848288

    Open questions at the time
    • Trafficking route of N-cadherin via ARF4 not defined
    • Single lab
  15. 2024 Medium

    Defined a triple-Arf requirement (ARF1/ARF4/ARF5) for ER export of receptor tyrosine kinases, reinforcing functional redundancy among Arf isoforms.

    Evidence siRNA triple knockdown, in vitro pulldown and RTK localization assays

    PMID:38679330

    Open questions at the time
    • Why all three Arfs are jointly required not mechanistically explained
    • Specific ARF4 contribution within the trio unresolved
  16. 2024 Medium

    Connected ARF4 retrograde trafficking to nuclear EGFR signaling, DNA-PK activation and temozolomide resistance in glioblastoma.

    Evidence CRISPR screen, ARF4 knockdown/overexpression, proteomics, spatial RNA-seq and intracranial PDX models

    PMID:38506351

    Open questions at the time
    • Direct ARF4 role in EGFR nuclear import step not defined
    • Single lab
  17. 2025 High

    Established ARF4 as a host factor required for Golgi-dependent egress of multiple RNA viruses and a druggable antiviral target.

    Evidence siRNA/CRISPR depletion, active/inactive ARF4 mutant complementation, Golgi/lysosome colocalization and in vivo peptide therapy

    PMID:39972062

    Open questions at the time
    • Viral cargo directly engaged by ARF4 not identified
    • How infection activates ARF4 not defined

Open questions

Synthesis pass · forward-looking unresolved questions
  • How ARF4 selects among its many cargoes and pathways — ciliary versus endosomal versus ER-export — and how Arf isoform redundancy is resolved in a tissue-specific manner remains unresolved.
  • No structural model of cargo/effector discrimination
  • Determinants of tissue-specific essentiality versus redundancy unknown
  • GEF/GAP regulatory cycle quantitatively undefined outside the rhodopsin system

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0003924 GTPase activity 3 GO:0060089 molecular transducer activity 2
Localization
GO:0005794 Golgi apparatus 3 GO:0005929 cilium 3 GO:0005768 endosome 1 GO:0005783 endoplasmic reticulum 1
Pathway
R-HSA-5653656 Vesicle-mediated transport 4 R-HSA-1643685 Disease 3 R-HSA-9609507 Protein localization 3 R-HSA-8953897 Cellular responses to stimuli 1
Partners
ARF1ARF5ASAP1FIP3GBF1RAB11USP7
Complex memberships
ARF4-ASAP1-Rab11-FIP3-Rab8 ciliary targeting complexGBF1-ARF4-rhodopsin complex

Evidence

Reading pass · 18 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2005 Human ARF4 (hARF4) directly interacts with Sec7p and suppresses yeast sec7 mutant growth by restoring the balance between cytosolic and membrane-associated Sec7p pools, supporting a role for ARF4 in vesicle coat dynamics and secretory pathway function. Genetic suppression screen (human cDNA library in conditional-lethal yeast sec7 mutants), complementation assays, subcellular fractionation Molecular and cellular biology Medium 8668142
2005 ARF4 directly binds the VxPx-COOH sorting motif of rhodopsin's C-terminus, and this interaction is required for generation of post-Golgi carriers targeted to rod outer segments; blocking ARF4 action phenocopies disruption of the rhodopsin C-terminal sorting signal and leads to aberrant trafficking. Binding assay (rhodopsin C-terminal peptide pulldown), dominant-negative ARF4 functional block in frog retina, vesicle budding assay Proceedings of the National Academy of Sciences of the United States of America High 15728366
2009 ARF4 assembles a ciliary targeting complex at the TGN comprising ARF4, Rab11, the Rab11/Arf effector FIP3, and the Arf GAP ASAP1; ASAP1 mediates GTP hydrolysis on ARF4 and functions as an ARF4 effector to regulate budding of post-TGN carriers. An ARF4 mutant (I46D) impaired in ASAP1-mediated GTP hydrolysis causes aberrant rhodopsin trafficking and retinal degeneration in transgenic animals. Co-immunoprecipitation, in vitro GTP hydrolysis assay, transgenic animal model (frog), live imaging of rhodopsin trafficking The EMBO journal High 19153612
2012 ASAP1 serves as a scaffold that brings together ARF4, Rab11, and Rab8 (via Rabin8) for ciliary cargo targeting; ASAP1 recognizes the FR ciliary targeting signal of rhodopsin. Ablation of ASAP1 abolishes ciliary targeting and causes actin-rich periciliary membrane projections accumulating mislocalized rhodopsin. siRNA knockdown, Co-immunoprecipitation, immunofluorescence, rhodopsin trafficking assays The EMBO journal High 22983554
2013 ARF4 depletion preserves viability, Golgi integrity, and cargo trafficking in the presence of brefeldin A (BFA), and these effects depend on the GEF GBF1 and ARF isoforms ARF1 and ARF5. ARF4 expression is induced by Golgi-disturbing agents and requires the CREB3 transcription factor, defining a CREB3-ARF4 signaling cascade as part of a Golgi stress response. Genome-wide haploid genetic screen, siRNA knockdown, Golgi morphology assays, pathogen infection assays, gene expression analysis Nature cell biology High 24185178
2013 Simultaneous depletion of ARF1 and ARF4 induces extensive tubulation of recycling endosomes and inhibits retrograde transport of TGN38 and mannose-6-phosphate receptor from early/recycling endosomes to the TGN, without affecting transferrin recycling or retrograde transport from late endosomes. siRNA knockdown (single and double depletion), immunofluorescence, transferrin recycling assay, cargo transport assays Molecular biology of the cell Medium 23783033
2012 Arf4 regulates dendritic spine development; Arf4(+/-) mice display spine loss and smaller mEPSCs in dentate gyrus granule cells. Constitutively active Arf4-Q71L promotes spine density more than wild-type, while inactive Arf4-T31N does not increase spine density. ASAP1 overexpression decreases spine density, an effect partially rescued by Arf4 or Arf4-Q71L co-overexpression. Arf4 heterozygous knockout mice, shRNA knockdown in primary neurons, overexpression of wild-type and mutant Arf4 constructs, spine density quantification, electrophysiology (mEPSC recording), behavioral pattern separation task PloS one Medium 23050017
2014 Arf4 binds to the ciliary targeting sequence (CTS) of fibrocystin; Arf4 knockdown causes a delay in delivery of newly synthesized fibrocystin CTS from the Golgi to the cilium, though steady-state CTS levels are unaffected. Arf4 mutant mice are embryonic lethal at mid-gestation with defects in visceral endoderm cell structure and apical protein localization but normal nodal cilia. Protein binding assay (Arf4-CTS interaction), siRNA knockdown with pulse-chase trafficking assay, conditional and global knockout mice, cilia functional assays (left-right symmetry) PLoS genetics Medium 24586199
2016 ARF4 is required for Presenilin-2 localization to basal bodies/cilia (via the VxPx motif) and for Notch signaling during epidermal differentiation; screening of ciliary targeting components identified ARF4 as necessary for Presenilin basal body localization and subsequent epidermal differentiation. siRNA knockdown, site-directed mutagenesis of VxPx motif, immunofluorescence, epidermal differentiation assays in skin development The Journal of cell biology Medium 27354375
2017 Arf4 deletion specifically in rod photoreceptors does not cause protein mislocalization or retinal degeneration, and Arf4 deletion in kidney does not cause cystic disease, arguing against a required role in ciliary trafficking in these tissues. Global Arf4 deletion causes severe pancreatic exocrine degeneration and early death, consistent with a critical role in endomembrane trafficking in the pancreas. Conditional and global knockout mice (Cre-lox), retinal protein localization by immunofluorescence, histology PLoS genetics High 28410364
2017 ARF4 is required for GBF1-dependent Arf4 activation at the Golgi/TGN; rhodopsin and Arf4 both bind the DCB-HUS regulatory domain of GBF1, forming a functional complex that is blocked by Golgicide A. This GBF1-Arf4-rhodopsin complex provides positive feedback to drive Arf4 activation during ciliary membrane trafficking. Co-immunoprecipitation with recombinant human proteins in frog retinas, Golgicide A pharmacological inhibition, pulse-chase trafficking assays Journal of cell science High 29025970
2017 ARF4 upregulation (induced by miR-21-5p via PTEN/PDCD4 suppression) increases intestinal epithelial permeability; ARF4 suppression in intestinal epithelial cells increases tight junction protein expression and decreases permeability. miRNA overexpression, RNAi knockdown of ARF4 and PTEN/PDCD4, tight junction protein expression assay (Western blot), intestinal permeability assay in Caco-2 cells and mouse intestinal epithelium The Journal of biological chemistry Medium 28760826
2021 USP7 directly interacts with ARF4 and catalyzes removal of K48-linked polyubiquitin chains from ARF4, stabilizing it as an anti-apoptotic substrate; USP7 inhibition enhances ARF4 ubiquitination and promotes apoptosis in glioblastoma cells. Co-immunoprecipitation, TMT proteomics, Western blotting, immunofluorescence, flow cytometry (apoptosis), intracranial xenograft model Cancer cell international Medium 34556124
2023 Arf4 knockdown in migrating cortical neurons causes stalling in the intermediate zone with disorientation of the Golgi and cytoplasmic accumulation of N-cadherin; exogenous N-cadherin supplementation partially rescues the migration defect, indicating Arf4 regulates radial migration via N-cadherin trafficking. In utero electroporation with shRNA knockdown, immunofluorescence (N-cadherin localization, Golgi orientation), time-lapse imaging of neuron migration, N-cadherin rescue experiment eNeuro Medium 37848288
2024 Simultaneous knockdown of ARF1, ARF4, and ARF5 (but not any single knockdown alone) blocks ER export of receptor tyrosine kinases (KIT, PDGFRA, EGFR, MET), mirroring the effect of BFA/M-COPA; in vitro pulldown assays confirmed BFA/M-COPA blocks ARF1, ARF4, and ARF5 function. RTKs require the simultaneous activation of ARF1, ARF4, and ARF5 for ER export. siRNA triple knockdown, in vitro pulldown assay, cell viability and apoptosis assays, immunofluorescence for RTK localization The Journal of biological chemistry Medium 38679330
2024 ARF4-mediated retrograde trafficking promotes nuclear EGFR (nEGFR) signaling and activates DNA-PK in glioblastoma; ARF4 suppression reduces nEGFR signaling and DNA-PK activity, enhancing temozolomide sensitivity. CRISPR-knockout screening, ARF4 knockdown/overexpression, proteomics, spatially resolved RNA-sequencing of patient tissue, intracranial PDX mouse models, kinase activity assays Neuro-oncology Medium 38506351
2025 ARF4 deletion suppresses infection by multiple RNA viruses (ZIKV, IAV, SARS-CoV-2); viral infection activates ARF4, and complementation with active ARF4 (but not inactive mutants) rescues virus production. Mechanistically, ARF4 deletion disrupts translocation of virus progeny into the Golgi complex and redirects them for lysosomal degradation. Peptides targeting ARF4 show antiviral efficacy in mouse challenge models. Genetic depletion (siRNA/CRISPR), ARF4 active/inactive mutant complementation, Golgi/lysosome co-localization assays, in vivo mouse infection models with therapeutic peptides Nature microbiology High 39972062
1995 Human ARF4 (ARF2) was mapped by fluorescence in situ hybridization to chromosome 3p21.2→p21.1. Fluorescence in situ hybridization (FISH) Cytogenetics and cell genetics Low 7956370

Source papers

Stage 0 corpus · 40 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2005 AUXIN RESPONSE FACTOR 2 (ARF2): a pleiotropic developmental regulator. The Plant journal : for cell and molecular biology 276 15960614
2009 Ciliary targeting motif VxPx directs assembly of a trafficking module through Arf4. The EMBO journal 214 19153612
2010 Auxin response factor 2 (ARF2) plays a major role in regulating auxin-mediated leaf longevity. Journal of experimental botany 173 20164142
2005 Rhodopsin C terminus, the site of mutations causing retinal disease, regulates trafficking by binding to ADP-ribosylation factor 4 (ARF4). Proceedings of the National Academy of Sciences of the United States of America 172 15728366
2013 A CREB3-ARF4 signalling pathway mediates the response to Golgi stress and susceptibility to pathogens. Nature cell biology 152 24185178
2016 Phosphorylation of ARF2 Relieves Its Repression of Transcription of the K+ Transporter Gene HAK5 in Response to Low Potassium Stress. The Plant cell 124 27895227
2012 The Arf GAP ASAP1 provides a platform to regulate Arf4- and Rab11-Rab8-mediated ciliary receptor targeting. The EMBO journal 107 22983554
2012 Failure of the tomato trans-acting short interfering RNA program to regulate AUXIN RESPONSE FACTOR3 and ARF4 underlies the wiry leaf syndrome. The Plant cell 105 23001036
2017 Commensal microbiota-induced microRNA modulates intestinal epithelial permeability through the small GTPase ARF4. The Journal of biological chemistry 102 28760826
2013 ARF1 and ARF4 regulate recycling endosomal morphology and retrograde transport from endosomes to the Golgi apparatus. Molecular biology of the cell 73 23783033
2017 MiR-221-3p targets ARF4 and inhibits the proliferation and migration of epithelial ovarian cancer cells. Biochemical and biophysical research communications 52 28057486
2018 Two TPL-Binding Motifs of ARF2 Are Involved in Repression of Auxin Responses. Frontiers in plant science 38 29619039
2021 ARF2 represses expression of plant GRF transcription factors in a complementary mechanism to microRNA miR396. Plant physiology 35 33580700
2012 Arf4 determines dentate gyrus-mediated pattern separation by regulating dendritic spine development. PloS one 33 23050017
2021 Auxin Response Factor 2 (ARF2), ARF3, and ARF4 Mediate Both Lateral Root and Nitrogen Fixing Nodule Development in Medicago truncatula. Frontiers in plant science 32 33897748
2017 Loss of Arf4 causes severe degeneration of the exocrine pancreas but not cystic kidney disease or retinal degeneration. PLoS genetics 32 28410364
1996 Human ARF4 expression rescues sec7 mutant yeast cells. Molecular and cellular biology 27 8668142
2014 Arf4 is required for Mammalian development but dispensable for ciliary assembly. PLoS genetics 25 24586199
2016 A Presenilin-2-ARF4 trafficking axis modulates Notch signaling during epidermal differentiation. The Journal of cell biology 24 27354375
2017 The Arf GEF GBF1 and Arf4 synergize with the sensory receptor cargo, rhodopsin, to regulate ciliary membrane trafficking. Journal of cell science 23 29025970
1995 Localization of human ARF2 and NCK genes and 13 other NotI-linking clones to chromosome 3 by fluorescence in situ hybridization. Cytogenetics and cell genetics 23 7956370
2019 The ins and outs of the Arf4-based ciliary membrane-targeting complex. Small GTPases 21 31068062
2013 Under-expression of the Auxin Response Factor Sl-ARF4 improves postharvest behavior of tomato fruits. Plant signaling & behavior 20 23857361
2020 ARF4 regulates shoot regeneration through coordination with ARF5 and IAA12. Plant cell reports 19 33180161
2022 ARF2-PIF5 interaction controls transcriptional reprogramming in the ABS3-mediated plant senescence pathway. The EMBO journal 18 35942625
2021 USP7 inhibition induces apoptosis in glioblastoma by enhancing ubiquitination of ARF4. Cancer cell international 14 34556124
2023 The ARF2-MYB6 module mediates auxin-regulated petal expansion in rose. Journal of experimental botany 13 37158672
2022 miR390-tasiRNA3-ARF4 pathway is involved in regulating flowering time in woodland strawberry. Plant cell reports 13 34985575
2020 Quantitative Proteomics Reveals Association of Neuron Projection Development Genes ARF4, KIF5B, and RAB8A With Hirschsprung Disease. Molecular & cellular proteomics : MCP 11 33561610
2025 ARF4-mediated intracellular transport as a broad-spectrum antiviral target. Nature microbiology 9 39972062
2024 Brefeldin A and M-COPA block the export of RTKs from the endoplasmic reticulum via simultaneous inactivation of ARF1, ARF4, and ARF5. The Journal of biological chemistry 6 38679330
2023 FTD/ALS Type 7-Associated Thr104Asn Mutation of CHMP2B Blunts Neuronal Process Elongation, and Is Recovered by Knockdown of Arf4, the Golgi Stress Regulator. Neurology international 5 37606396
2023 ADP Ribosylation Factor 4 (Arf4) Regulates Radial Migration through N-Cadherin Trafficking during Cerebral Cortical Development. eNeuro 5 37848288
2024 ARF4-mediated retrograde trafficking as a driver of chemoresistance in glioblastoma. Neuro-oncology 2 38506351
2024 Endothelial NMMHC IIA dissociation from PAR1 activates the CREB3/ARF4 signaling in thrombin-mediated intracerebral hemorrhage. Journal of advanced research 2 39521432
2007 Molecular cloning and expression analyses of a novel swine gene--ARF4. Molecular biology reports 2 18157702
2026 Heme oxygenase-1 attenuates sepsis-associated acute lung injury by suppressing the CREB3/ARF4 signaling pathway to mitigate Golgi stress in macrophages. Free radical biology & medicine 0 41967721
2026 MAPK pathway inhibitors enhance radioiodine sensitivity in anaplastic thyroid carcinoma through promoting NIS expression and ARF4-mediated NIS membrane transport. Scientific reports 0 42236533
2025 Conserved roles of ETT and ARF4 in gynoecium development in Brassicaceae with distinct fruit shapes. Development (Cambridge, England) 0 39936596
2024 [Characterization of host factors ARF4 and ARF5 upon Zika virus infection in vivo by construction of gene knockout mice]. Sheng wu gong cheng xue bao = Chinese journal of biotechnology 0 39722520

Missed literature

Know a paper Affinage missed for ARF4? Flag it for the maintainers and the community.

No submissions yet.