Affinage

ATP5F1B

ATP synthase F(1) complex subunit beta, mitochondrial · UniProt P06576

Round 2 corrected
Length
529 aa
Mass
56.6 kDa
Annotated
2026-04-28
56 papers in source corpus 22 papers cited in narrative 22 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

ATP5F1B is the catalytic β-subunit of mitochondrial F1-ATPase (Complex V), whose three copies cycle through distinct nucleotide-bound conformations to drive rotary ATP synthesis, as established by the landmark bovine F1 crystal structure (PMID:8065448). Beyond its canonical mitochondrial role, ATP5F1B is ectopically displayed on the plasma membrane of hepatocytes, endothelial cells, and cancer cells, where it functions as a high-affinity receptor for apoA-I mediating HDL endocytosis (PMID:12511957), a binding site for angiostatin mediating anti-angiogenic signaling (PMID:10077593), and a receptor for the HBV preS1 peptide facilitating viral entry (PMID:36076968). Catalytic activity is regulated by MOF-mediated acetylation at K201 (counteracted by SIRT3), with hyperacetylation impairing mitochondrial respiration and causing cardiac remodeling in vivo (PMID:39392752). Heterozygous dominant-negative missense variants in ATP5F1B (p.Thr334Pro, p.Val482Ala) cause Complex V deficiency and autosomal dominant early-onset dystonia (PMID:36860166).

Mechanistic history

Synthesis pass · year-by-year structured walk · 11 steps
  1. 1994 High

    The fundamental question of how the three β-subunits of F1-ATPase collaborate during catalysis was resolved by determining that each β-subunit simultaneously adopts a distinct nucleotide-bound conformation, providing the structural basis for the rotary catalytic mechanism.

    Evidence X-ray crystallography of bovine mitochondrial F1-ATPase at 2.8 Å resolution

    PMID:8065448

    Open questions at the time
    • Rotation was structurally inferred but not yet directly observed
    • No human-specific structure at the time
    • Post-translational regulatory mechanisms unknown
  2. 1999 High

    The discovery that ATP5F1B is ectopically expressed on the endothelial cell surface and serves as the angiostatin receptor established that ATP synthase subunits have non-canonical extramitochondrial functions.

    Evidence Ligand blot, N-terminal sequencing, flow cytometry, and antibody blocking of angiostatin's antiproliferative effect on endothelial cells

    PMID:10077593

    Open questions at the time
    • Mechanism of ATP5F1B trafficking to the plasma membrane unresolved
    • Stoichiometry and assembly state of ectopic complex unknown
  3. 2003 High

    Ectopic ATP5F1B on hepatocytes was shown to function as a high-affinity apoA-I receptor whose ATP hydrolase activity generates ADP to trigger HDL endocytosis, establishing a physiological role for cell-surface ATP synthase in lipoprotein metabolism.

    Evidence Receptor isolation from hepatocyte membranes, surface activity assays, and ex vivo perfused rat liver endocytosis experiments

    PMID:12511957

    Open questions at the time
    • Structural basis for apoA-I recognition by ectopic β-subunit undetermined
    • In vivo contribution to systemic HDL clearance not quantified
  4. 2011 Medium

    ATP5F1B was identified as a pro-viral host factor for HSV-1 (regulated via miR-101 targeting of its 3′UTR) and as a plasma membrane signaling partner of the calcium channel α2/δ1 subunit in developing myotubes, broadening its functional repertoire beyond energy metabolism.

    Evidence 3′UTR luciferase reporter plus siRNA/plaque assays for HSV-1; FRET, Co-IP, and calcium transient imaging in myotubes

    PMID:21291913 PMID:21490313

    Open questions at the time
    • Molecular mechanism by which ATP5F1B promotes HSV-1 replication unclear
    • Whether the calcium channel interaction occurs independently of ectopic ATP synthase complex is unknown
  5. 2019 High

    ATP5F1B was shown to bind rotavirus RNA 3′UTR consensus sequences and promote late-stage viral particle maturation without affecting RNA replication, pinpointing its pro-viral contribution to a specific assembly step.

    Evidence RaPID RNA–protein interaction screen, siRNA knockdown, chemical inhibition in cell lines and human intestinal enteroids

    PMID:30770472

    Open questions at the time
    • Whether ATP5F1B's RNA-binding and catalytic functions are separable in the viral context is untested
    • No structural data on the ATP5F1B–RV RNA interface
  6. 2022 Medium

    Cell-surface ATP5F1B on hepatocytes was identified as a receptor for the myristoylated preS1 domain of HBV, with knockdown reducing cccDNA formation, establishing ATP5F1B as an entry co-factor for HBV alongside NTCP.

    Evidence Flow cytometry, myristoylated peptide binding assay, siRNA knockdown with cccDNA quantification in NTCP-expressing HepG2 cells

    PMID:36076968

    Open questions at the time
    • Relative contribution of ATP5F1B versus NTCP to HBV entry kinetics not delineated
    • Whether ATP hydrolase activity is required for HBV internalization is unknown
  7. 2023 High

    Heterozygous missense variants in ATP5F1B were shown to cause autosomal dominant early-onset dystonia through a dominant-negative mechanism that severely impairs Complex V activity while preserving protein levels, establishing ATP5F1B as a Mendelian disease gene.

    Evidence Genetic segregation in families, Complex V enzymatic activity and mitochondrial membrane potential assays in patient fibroblasts

    PMID:36860166

    Open questions at the time
    • No structural explanation for how p.Thr334Pro and p.Val482Ala exert dominant-negative effects
    • Penetrance modifiers not identified
    • No animal model recapitulating the dystonia phenotype
  8. 2023 Medium

    ATP5F1B was found to bind HIF-1α mRNA and mediate translational inhibition when engaged by adamantaniline-containing small molecules, revealing an unexpected role as an RNA-binding translational regulator.

    Evidence Chemoproteomic target identification (affinity-based protein profiling), mRNA-binding assay, HIF-1α translation assay, in vivo xenograft model

    PMID:37401167

    Open questions at the time
    • Endogenous regulation of HIF-1α translation by ATP5F1B in the absence of small molecules not demonstrated
    • RNA-binding site on ATP5F1B not mapped
  9. 2023 Medium

    Under PFOS-induced stress, redistribution of ATP5F1B from the plasma membrane to mitochondria was shown to drive pathological iron and calcium overload by chaperoning TFR2 and bridging TRPML1–VDAC1, linking ectopic ATP5F1B trafficking to mitochondria-associated membrane signaling.

    Evidence Co-IP, subcellular fractionation, calcium and iron imaging, siRNA knockdown, and pharmacological stabilization of surface ATP5F1B in hepatocytes and mouse liver

    PMID:36801541 PMID:38626609 PMID:38944014

    Open questions at the time
    • Whether ATP5F1B redistribution occurs in physiological (non-PFOS) contexts is unknown
    • Direct biophysical evidence for a ternary ATP5F1B–TRPML1–VDAC1 complex is lacking
    • Mechanism by which ATP5F1B promotes VDAC1 oligomerization is undefined
  10. 2024 High

    MOF-mediated acetylation of ATP5F1B at K201, counteracted by SIRT3, was established as a regulatory switch for mitochondrial respiration; hyperacetylation impairs Complex V activity and causes cardiac remodeling and heart failure in vivo.

    Evidence Quantitative acetylome mass spectrometry, mitochondria-targeted MOF overexpression and SIRT3 knockout mouse models, mitochondrial respiration and cardiac phenotyping

    PMID:39392752

    Open questions at the time
    • Whether K201 acetylation affects rotary mechanism or assembly is not structurally resolved
    • Tissue-specific acetylation dynamics beyond heart are unexplored
  11. 2025 Medium

    ATP5F1B was shown to interact with Cend1, whose dimerization is required for full Complex V activity and neuroprotection during cerebral ischemia/reperfusion, revealing a regulatory partner that modulates ATP synthase function in the brain.

    Evidence Cend1 knockout mice, Co-IP, mutagenesis of Cend1 GXXXA dimerization motifs, small molecule (Tianeptine) stabilization of Cend1 dimers

    PMID:41469760

    Open questions at the time
    • Direct binding interface between ATP5F1B and Cend1 not mapped
    • Whether Cend1 is a stoichiometric complex subunit or a transient regulator is unclear

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key unresolved questions include the structural mechanism of ATP5F1B trafficking to the plasma membrane, the molecular basis for its multi-target RNA-binding capacity, how dominant-negative dystonia variants structurally disrupt the F1 hexamer, and whether ectopic versus mitochondrial pools of ATP5F1B are independently regulated.
  • No trafficking mechanism for ectopic ATP5F1B established
  • No cryo-EM or crystal structure of disease-mutant F1 complex
  • Relative physiological importance of RNA-binding versus catalytic functions undetermined

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140657 ATP-dependent activity 4 GO:0003723 RNA binding 2 GO:0016787 hydrolase activity 2 GO:0001618 virus receptor activity 1 GO:0005198 structural molecule activity 1
Localization
GO:0005886 plasma membrane 9 GO:0005739 mitochondrion 8
Pathway
R-HSA-1430728 Metabolism 5 R-HSA-1643685 Disease 5 R-HSA-382551 Transport of small molecules 3 R-HSA-162582 Signal Transduction 2 R-HSA-168256 Immune System 2
Partners
ATP5F1ACAV1CEND1KAT8SIRT3TFR2TRPML1VDAC1
Complex memberships
Ectopic cell-surface ATP synthase complexF1-ATPase (mitochondrial ATP synthase F1 sector)

Evidence

Reading pass · 22 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1994 Crystal structure of bovine mitochondrial F1-ATPase at 2.8 Å resolution revealed that the three catalytic β-subunits (ATP5F1B orthologs) differ in conformation and bound nucleotide, supporting a rotary catalytic mechanism in which the three catalytic subunits are in different states of the catalytic cycle at any instant, with interconversion achieved by rotation of the α3β3 subassembly relative to the γ-subunit. X-ray crystallography at 2.8 Å resolution Nature High 8065448
1999 The β-subunit of ATP synthase (ATP5F1B) is present on the surface of human endothelial cells and functions as a binding protein for angiostatin; angiostatin binding to cell-surface ATP synthase α/β-subunits mediates its antiproliferative and antiangiogenic effects on endothelial cells. Ligand blot analysis, amino-terminal sequencing, peptide mass fingerprinting, immunologic analysis, flow cytometry, immunofluorescence, anti-subunit antibody inhibition of angiostatin antiproliferative effect Proceedings of the National Academy of Sciences of the United States of America High 10077593
2003 The β-chain of ATP synthase (ATP5F1B) is ectopically expressed on the surface of hepatocytes and functions as a high-affinity receptor for apolipoprotein A-I (apoA-I), mediating HDL endocytosis; receptor stimulation by apoA-I triggers holo-HDL endocytosis via a mechanism strictly dependent on ADP generation by cell-surface ATP hydrolase activity. Biochemical receptor isolation, immunologic confirmation of ectopic localization, cell-surface ATP hydrolase activity assay, endocytosis assay with ATP synthase inhibitor in perfused rat liver ex vivo Nature High 12511957
2011 miR-101 directly binds to the 3'UTR of ATP5F1B (ATP5B) mRNA and negatively regulates ATP5B protein expression; knockdown of ATP5B significantly inhibits HSV-1 replication, demonstrating that ATP5B functions as a pro-viral host factor for HSV-1. Luciferase 3'UTR reporter assay, siRNA knockdown, plaque assay, real-time PCR Antiviral research Medium 21291913
2011 ATP5F1B (ATP5B) interacts with the calcium channel α2/δ1 subunit at the plasma membrane of developing myotubes, forming a functional signaling complex that accelerates the rate of decline of calcium transients, particularly during trains of stimulation pulses. FRET, coimmunoprecipitation, fluorescence imaging, calcium transient measurements in myotubes American journal of physiology. Cell physiology Medium 21490313
2012 In a mouse model of multiple sclerosis (ND4 mice), the mRNA export factor REF undergoes loss of deimination (arginine-to-citrulline conversion), which impairs its binding strength to ATP5F1B mRNA and reduces ATP5B mRNA transport to mitochondria; pharmacological inhibition of deimination in PC12 cells reduced mitochondrial ATP synthase activity. mRNA binding assay, mRNA transport assay, ATP synthase activity assay after deimination inhibition EMBO reports Medium 22261716
2016 Knockdown of Atp5b in mouse spermatocytes (GC2 cells) decreased mitochondrial membrane potential and induced apoptosis, demonstrating that Atp5b is required for maintaining mitochondrial integrity in spermatocytes. siRNA knockdown, flow cytometry (mitochondrial membrane potential, apoptosis assay) Environmental toxicology and pharmacology Medium 27525561
2019 ATP5F1B (ATP5B) binds to the 3'UTR consensus sequences of rotavirus (RV) RNA with high affinity; during RV infection, ATP5B co-localizes with viral RNA and viroplasm; siRNA-mediated depletion of ATP5B (or other ATP synthase subunits) reduces production of infectious viral progeny without altering intracellular viral RNA levels or translation, placing ATP5B as a positive regulator of late-stage RV maturation/particle formation. RaPID proteomics-based RNA-protein interaction screen, siRNA knockdown, viral plaque assay, chemical inhibition in human intestinal enteroids The Journal of biological chemistry High 30770472
2021 ATP5F1B (ATP5B) overexpression in gastric cancer cells elevates intracellular ATP content, increases extracellular ATP secretion, activates the P2X7 purinergic receptor, and thereby activates the FAK/AKT/MMP2 signaling pathway to promote cell migration, invasion, and proliferation; inhibitors of P2X7, FAK, AKT, and MMP2 suppress these effects. Overexpression and knockdown in gastric cancer cell lines, ATP content assay, migration/invasion assays, Western blotting for pathway components, pharmacological inhibitor experiments FASEB journal Medium 33715234
2021 Inhibition of ATP5F1B (ATP5B) by siRNA lentivirus impairs osteoclast differentiation, suppresses osteoclast-related gene and protein expression, significantly impairs F-actin ring formation, decreases adhesion-associated proteins, causes mitochondrial dysfunction, and impairs vacuolar proton secretion and MMP9 secretion, thereby protecting arthritic mouse joints from bone erosion. Lentiviral siRNA delivery in vitro and intra-articular in vivo, gene/protein expression analysis, F-actin staining, bone resorption pit assay, mitochondrial function assay Pharmacological research Medium 33515708
2021 Ectopic ATP5F1B (ATP5B) at the plasma membrane co-localizes and physically interacts with caveolin-1 (Cav-1) in MDA-MB-231 breast cancer cells; Cav-1 knockdown reduces migration and invasion abilities and is required for the pro-migratory/invasive function of ectopic ATP5B. Coimmunoprecipitation, double immunofluorescence staining, siRNA knockdown, migration/invasion assays Medical oncology Medium 34009483
2022 Cell-surface ATP5F1B (ATP5B) on hepatocellular carcinoma cells binds the myristoylated (but not non-myristoylated) preS1 2-47 peptide of hepatitis B virus; knockdown of ATP5B in NTCP-expressing HepG2 cells reduces HBV infectivity with less cccDNA formation, establishing ATP5B as an essential factor for HBV cell entry. Flow cytometry (cell surface expression), binding assay with myristoylated preS1 peptide, siRNA knockdown, HBV infection assay (cccDNA quantification) International journal of molecular sciences Medium 36076968
2023 Two heterozygous missense variants in ATP5F1B (p.Thr334Pro and p.Val482Ala) segregate with autosomal dominant early-onset isolated dystonia with incomplete penetrance; functional studies in patient fibroblasts showed preserved ATP5F1B protein levels but severe reduction of complex V (ATP synthase) activity and impaired mitochondrial membrane potential, consistent with a dominant-negative mechanism. Genetic segregation analysis, protein quantification, complex V enzymatic activity assay, mitochondrial membrane potential measurement in patient fibroblasts Brain High 36860166
2023 ATP5F1B (ATP5B) binds HIF-1α mRNA; small molecules (HI-derivatives containing an adamantaniline moiety) promote this binding and thereby inhibit HIF-1α translation without affecting mRNA levels; target identification was achieved via affinity-based protein profiling of the probe HI-102. Affinity-based protein profiling (chemoproteomic target ID), mRNA-binding assay, HIF-1α protein expression and translation assay, in vivo xenograft model Advanced science Medium 37401167
2023 Under PFOS exposure, ATP5F1B (ATP5B) redistributes from the plasma membrane to mitochondria and interacts with transferrin receptor 2 (TFR2), facilitating TFR2 translocation to mitochondria, leading to mitochondrial iron overload that precedes and causes insulin resistance; stabilizing ATP5B on the plasma membrane or knockdown of ATP5B blocked TFR2 translocation and prevented insulin resistance. Subcellular fractionation, Co-IP, pharmacological inhibition of ectopic ATP synthase, ATP5B knockdown, mitochondrial iron measurement, insulin resistance assays in hepatocytes and mouse liver Ecotoxicology and environmental safety Medium 36801541
2024 Mitochondria-localized acetyltransferase MOF directly acetylates ATP5F1B (ATP5B) at lysine K201; this acetylation, co-regulated by the deacetylase SIRT3, impairs mitochondrial respiration and energy metabolism; overexpression of mitochondria-targeted MOF in mice causes mitochondrial dysfunction, cardiac remodeling, and heart failure, and SIRT3 knockout aggravates these effects. Quantitative lysine acetylome mass spectrometry, mitochondria-targeted MOF overexpression mouse model, SIRT3 knockout, mitochondrial respiration assay, cardiac phenotyping Cell reports High 39392752
2024 Under PFOS exposure, ATP5F1B (ATP5B) interacts with TRPML1 (lysosomal calcium channel) and VDAC1 (mitochondrial calcium channel), facilitating calcium transmission from lysosomes to mitochondria; inhibiting ATP5B expression or retaining ATP5B on the plasma membrane disrupts TRPML1-VDAC1 interaction and reverses mitochondrial calcium overload and insulin resistance. Co-IP, subcellular fractionation, siRNA knockdown, calcium imaging, pharmacological inhibition, mouse liver experiments Ecotoxicology and environmental safety Medium 38626609
2024 Under PFOS exposure, ATP5F1B (ATP5B) interacts with VDAC1 and promotes VDAC1 translocation from the plasma membrane to mitochondria, where it undergoes oligomerization; this VDAC1 oligomerization activates the NLRP3 inflammasome; knockdown of ATP5B or immobilization of ATP5B on the plasma membrane prevents VDAC1 oligomerization and NLRP3 activation. Co-IP, VDAC1 oligomerization assay, siRNA knockdown, plasma membrane ATP5B stabilization, NLRP3 inflammasome activation assay in hepatocytes and mouse liver Ecotoxicology and environmental safety Medium 38944014
2024 ATP5F1B (ATP5B) interacts with TGEV (transmissible gastroenteritis coronavirus) nonstructural protein Nsp2; downregulation of ATP5B promotes TGEV replication, indicating that ATP5B functions as a negative regulator of TGEV replication. Immunoprecipitation/LC-MS/MS, Co-IP, indirect immunofluorescence, siRNA knockdown with viral replication assay Virulence Medium 39239724
2025 ATP5F1B (Atp5f1b) interacts with the mitochondrial protein Cend1; Cend1 deficiency in knockout mice exacerbates cerebral ischemia/reperfusion injury with impaired mitochondrial membrane potential, mPTP opening, ATP content reduction, and decreased Complex V activity; Cend1 dimerization via GXXXA motifs is required for ATP synthesis enhancement; the small molecule Tianeptine stabilizes Cend1 dimers, elevates ATP, and confers neuroprotection in a Cend1-dependent manner. Cend1 knockout mouse model, Co-IP (Atp5f1b-Cend1 interaction), mitochondrial function assays, mutagenesis (G130P), small molecule treatment, neurological phenotyping Communications biology Medium 41469760
2023 The Pseudomonas aeruginosa flagellar hook protein FlgE directly interacts with cell-surface ATP5F1B (ATP5B) on macrophages, and blocking ATP5B attenuates FlgE-induced NF-κB/MAPK signaling, inflammatory responses, SR-A1 upregulation, and foam cell formation, indicating ATP5B mediates pathogen-induced pro-atherogenic macrophage activation. Pull-down assay, Western blotting, blocking experiments with anti-ATP5B, in vitro macrophage assays, ApoE-/- mouse atherosclerosis model Atherosclerosis Low 38278062
2020 The bovine ATP5F1B (ATP5B) promoter contains two transcriptional start sites; the transcription factors MyoD and GATA1 bind to specific sites in the proximal promoter region (-539/+220 relative to TSS) and drive ATP5B basal transcription, as demonstrated by 5'-RACE, deletion analysis, site-directed mutagenesis, and ChIP assays. 5'-RACE, luciferase reporter deletion assay, site-directed mutagenesis, chromatin immunoprecipitation (ChIP) Animal biotechnology Medium 33124493

Source papers

Stage 0 corpus · 56 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1994 Structure at 2.8 A resolution of F1-ATPase from bovine heart mitochondria. Nature 2506 8065448
2005 A human protein-protein interaction network: a resource for annotating the proteome. Cell 1704 16169070
2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America 1479 12477932
2015 The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell 1118 26186194
2017 Architecture of the human interactome defines protein communities and disease networks. Nature 1085 28514442
2015 A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell 1015 26496610
2014 A proteome-scale map of the human interactome network. Cell 977 25416956
2005 Nucleolar proteome dynamics. Nature 934 15635413
2020 A reference map of the human binary protein interactome. Nature 849 32296183
2018 VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell discovery 829 29507755
2002 Directed proteomic analysis of the human nucleolus. Current biology : CB 780 11790298
2021 Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Cell 705 33961781
2012 A census of human soluble protein complexes. Cell 689 22939629
2011 Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Briefings in bioinformatics 656 21873635
2008 Genome-scale RNAi screen for host factors required for HIV replication. Cell host & microbe 627 18976975
2008 Large-scale proteomics and phosphoproteomics of urinary exosomes. Journal of the American Society of Nephrology : JASN 607 19056867
2011 Global landscape of HIV-human protein complexes. Nature 593 22190034
2017 Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15. Science (New York, N.Y.) 533 28302793
2021 Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV. Nature 532 33845483
1999 Angiostatin binds ATP synthase on the surface of human endothelial cells. Proceedings of the National Academy of Sciences of the United States of America 439 10077593
2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome research 438 15489334
2022 OpenCell: Endogenous tagging for the cartography of human cellular organization. Science (New York, N.Y.) 432 35271311
2011 Defining human ERAD networks through an integrative mapping strategy. Nature cell biology 427 22119785
2015 Panorama of ancient metazoan macromolecular complexes. Nature 407 26344197
2003 Ectopic beta-chain of ATP synthase is an apolipoprotein A-I receptor in hepatic HDL endocytosis. Nature 389 12511957
2004 Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. Current biology : CB 386 15324660
2005 Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular pathways. Proceedings of the National Academy of Sciences of the United States of America 383 16009940
2004 14-3-3-affinity purification of over 200 human phosphoproteins reveals new links to regulation of cellular metabolism, proliferation and trafficking. The Biochemical journal 372 14744259
2015 Proteome-wide profiling of protein assemblies by cross-linking mass spectrometry. Nature methods 370 26414014
2007 Functional specialization of beta-arrestin interactions revealed by proteomic analysis. Proceedings of the National Academy of Sciences of the United States of America 360 17620599
2011 MiR-101 regulates HSV-1 replication by targeting ATP5B. Antiviral research 94 21291913
2015 ATP5A1 and ATP5B are highly expressed in glioblastoma tumor cells and endothelial cells of microvascular proliferation. Journal of neuro-oncology 52 26526033
2013 Metabolic markers GAPDH, PKM2, ATP5B and BEC-index in advanced serous ovarian cancer. BMC clinical pathology 38 24252137
2021 ATP5B promotes the metastasis and growth of gastric cancer by activating the FAK/AKT/MMP2 pathway. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 28 33715234
2016 2,2',4,4'-Tetrabromodiphenyl ether injures cell viability and mitochondrial function of mouse spermatocytes by decreasing mitochondrial proteins Atp5b and Uqcrc1. Environmental toxicology and pharmacology 27 27525561
2019 Profiling of rotavirus 3'UTR-binding proteins reveals the ATP synthase subunit ATP5B as a host factor that supports late-stage virus replication. The Journal of biological chemistry 22 30770472
2014 Investigation of the association between ATP2B4 and ATP5B genes with colorectal cancer. Gene 20 24583174
2013 Porcine skeletal muscle differentially expressed gene ATP5B: molecular characterization, expression patterns, and association analysis with meat quality traits. Mammalian genome : official journal of the International Mammalian Genome Society 19 23420545
2017 Overexpression of ATP5b promotes cell proliferation in asthma. Molecular medicine reports 17 28901394
2024 Mitochondrial MOF regulates energy metabolism in heart failure via ATP5B hyperacetylation. Cell reports 15 39392752
2021 Targeted inhibition of ATP5B gene prevents bone erosion in collagen-induced arthritis by inhibiting osteoclastogenesis. Pharmacological research 15 33515708
2011 The calcium channel α2/δ1 subunit interacts with ATP5b in the plasma membrane of developing muscle cells. American journal of physiology. Cell physiology 15 21490313
2023 Mitochondrial iron overload mediated by cooperative transfer of plasma membrane ATP5B and TFR2 to mitochondria triggers hepatic insulin resistance under PFOS exposure. Ecotoxicology and environmental safety 14 36801541
2023 Variants in ATP5F1B are associated with dominantly inherited dystonia. Brain : a journal of neurology 13 36860166
2023 Adamantaniline Derivatives Target ATP5B to Inhibit Translation of Hypoxia Inducible Factor-1α. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 10 37401167
2024 Autophagy-dependent lysosomal calcium overload and the ATP5B-regulated lysosomes-mitochondria calcium transmission induce liver insulin resistance under perfluorooctane sulfonate exposure. Ecotoxicology and environmental safety 9 38626609
2014 Determining ACTB, ATP5B and RPL32 as optimal reference genes for quantitative RT-PCR studies of cryopreserved stallion semen. Animal reproduction science 9 25192831
2024 The VDAC1 oligomerization regulated by ATP5B leads to the NLRP3 inflammasome activation in the liver cells under PFOS exposure. Ecotoxicology and environmental safety 8 38944014
2021 The function of Cav-1 in MDA-MB-231 breast cancer cell migration and invasion induced by ectopic ATP5B. Medical oncology (Northwood, London, England) 8 34009483
2012 The role of deimination in ATP5b mRNA transport in a transgenic mouse model of multiple sclerosis. EMBO reports 7 22261716
2022 ATP5B Is an Essential Factor for Hepatitis B Virus Entry. International journal of molecular sciences 6 36076968
2016 ATP5B and ETFB metabolic markers in children with congenital hydronephrosis. Molecular medicine reports 4 27840937
2023 Flagellar hook protein FlgE promotes macrophage activation and atherosclerosis by targeting ATP5B. Atherosclerosis 2 38278062
2020 Characterization of the promoter region of bovine ATP5B: roles of MyoD and GATA1 in the regulation of basal transcription. Animal biotechnology 1 33124493
2025 Targeting Cend1-Atp5f1b interaction rescues mitochondrial dysfunction and ameliorates ischemic brain injury. Communications biology 0 41469760
2024 ATP synthase subunit ATP5B interacts with TGEV Nsp2 and acts as a negative regulator of TGEV replication. Virulence 0 39239724