Affinage

CAV1

Caveolin-1 · UniProt Q03135

Length
178 aa
Mass
20.5 kDa
Annotated
2026-06-09
100 papers in source corpus 16 papers cited in narrative 16 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 7/8 claims corpus-supported (88%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

CAV1 (Caveolin-1) is an integral membrane protein required for caveolae biogenesis that organizes lipid raft microdomains and serves as a scaffold coupling membrane organization to multiple signaling pathways (PMID:26918609, PMID:34643546). Its essential structural role is established by biallelic null variants causing congenital generalized lipodystrophy, in which patient fibroblasts lose caveolae entirely, lack caveolin-1 protein, and show concomitant loss of its partners CAV2 and CAVIN1, demonstrating that CAV1 is required for caveolae formation and for stabilization of these partner proteins (PMID:34643546); a de novo frame-shift mutation similarly causes a neonatal progeroid/lipodystrophy syndrome via loss of function (PMID:26176221). At the membrane, CAV1 co-resides with c-Src and EGFR in cholesterol-dependent lipid rafts, and disrupting raft integrity displaces these components and modulates downstream signaling (PMID:26918609). CAV1 negatively regulates endothelial eNOS/NO signaling, with its loss elevating eNOS activity in contexts of intraocular pressure and aqueous outflow (PMID:27228562, PMID:32428234), and it constrains JNK and NF-kB inflammatory signaling in vascular smooth muscle during atherosclerosis (PMID:29746866). CAV1 also participates in autophagy: phosphorylation at tyrosine-14 enables its scaffolding-domain-dependent interaction with the BECN1/VPS34 complex to promote autophagosome formation under oxidative stress, an interaction reversed by the phosphatase PTPN1 (PMID:28542134), while CAV1 itself is turned over by autophagy through a CAVIN1-LC3B axis under control of the AMPK-MTOR-PIK3C3 pathway (PMID:31448673). In cancer, CAV1 acts as a context-dependent regulator of invasion and EMT, driving HCC metastasis via Wnt/beta-catenin and ERK-dependent MMP-7 induction (PMID:25180681) and functioning as a transcriptional target and effector in other tumor pathways (PMID:17047056, PMID:29752441). More recently, CAV1 was found to mark intraluminal vesicles delivered to migrasomes via a Rab10/Myosin Va/RILPL2 transport pathway regulated by LRRK2 phosphorylation of Rab10 (PMID:39008679). CAV1 loss also disrupts hematopoietic stem cell quiescence (PMID:24675458) and is linked through enhancer variants to ALS via membrane lipid raft disruption (PMID:33264630).

Mechanistic history

Synthesis pass · year-by-year structured walk · 13 steps
  1. 2006 High

    Established CAV1 as a transcriptionally regulated effector with a defined role in the EMT/oncogenic program, linking it to Snail/E-cadherin control of anchorage-independent growth.

    Evidence ChIP, shRNA knockdown, re-expression rescue, and nude mouse xenografts in Ewing's sarcoma cells

    PMID:17047056

    Open questions at the time
    • Does not define how CAV1 mechanistically represses Snail
    • Tumor-type-specific; does not establish a general CAV1 EMT mechanism
  2. 2014 Medium

    Defined CAV1 as a positive driver of invasion and EMT through Wnt/beta-catenin and ERK-MMP-7 signaling, contrasting with its tumor-suppressive role in other contexts.

    Evidence Gain/loss-of-function with in vitro invasion and in vivo metastasis models in HCC

    PMID:25180681

    Open questions at the time
    • Mechanism by which CAV1 couples to Wnt/beta-catenin not resolved
    • Reconciliation of pro- vs anti-oncogenic roles not addressed
  3. 2014 Medium

    Showed CAV1 is required to maintain hematopoietic stem cell quiescence, expanding its role beyond signaling into stem cell biology.

    Evidence Cav1 KO mice with competitive transplantation, clonogenic assays, and cell cycle analysis

    PMID:24675458

    Open questions at the time
    • Molecular link between CAV1 and quiescence machinery undefined
    • Caveolae dependence of the HSC phenotype not tested
  4. 2016 Medium

    Positioned CAV1 within cholesterol-dependent lipid rafts as a scaffold co-organizing c-Src and EGFR, mechanistically tying membrane raft integrity to downstream signaling activation.

    Evidence Sucrose density fractionation, STED imaging, and MbetaCD cholesterol depletion with Dsg2 manipulation

    PMID:26918609

    Open questions at the time
    • Direct CAV1-EGFR/c-Src binding not distinguished from co-residence
    • Does not establish stoichiometry or scaffolding domain requirement
  5. 2016 Medium

    Demonstrated CAV1 negatively regulates eNOS/NO signaling in the conventional outflow pathway, mechanistically connecting CAV1 loss to elevated intraocular pressure.

    Evidence Cav1 KO mice with tonometry, outflow facility measurement, NOS pharmacology, and eNOS phospho-state western blots

    PMID:27228562

    Open questions at the time
    • The proposed protein kinase K nitration mechanism is correlative
    • Cell type responsible for outflow phenotype not pinpointed
  6. 2017 High

    Identified a phospho-switch controlling CAV1's autophagic function, where Y14 phosphorylation enables scaffolding-domain binding to BECN1/VPS34 to drive autophagy under oxidative stress.

    Evidence Reciprocal Co-IP, Y14 phospho-mutants, PTPN1 phosphatase overexpression, and Cav1 KO mouse stroke model with LC3 imaging

    PMID:28542134

    Open questions at the time
    • Kinase phosphorylating CAV1-Y14 in this context not identified
    • Structural basis of the scaffolding-domain/BECN1 interaction not resolved
  7. 2018 Medium

    Placed CAV1 upstream of JNK and NF-kB inflammatory signaling in vascular smooth muscle, defining its anti-atherosclerotic role through pathway-position rescue.

    Evidence Cav1-/- ApoE-/- mice with JNK activator rescue in ox-LDL-treated VSMCs

    PMID:29746866

    Open questions at the time
    • Direct molecular link between CAV1 and MKK7/JNK not shown
    • Whether effect requires caveolae not tested
  8. 2018 Medium

    Showed CAV1alpha isoform expression is controlled post-transcriptionally by PTBP3-mediated alternative splicing, placing a specific CAV1 isoform downstream in FAK/Src-driven metastasis.

    Evidence RNA immunoprecipitation, dual-luciferase reporters, and xenotransplant in gastric cancer

    PMID:29752441

    Open questions at the time
    • Functional difference between CAV1 isoforms not mechanistically dissected
    • How CAV1alpha modulates FAK/Src unresolved
  9. 2019 Medium

    Defined the autophagic turnover route of CAV1 itself, showing the AMPK-MTOR-PIK3C3 pathway controls CAV1 degradation via a CAVIN1-LC3B axis to regulate caveolae abundance and LDL transcytosis.

    Evidence Autophagy flux assays, AMPK-MTOR inhibition, CAV1 manipulation, LDL transcytosis assays, and gestational diabetes patient tissue

    PMID:31448673

    Open questions at the time
    • Direct CAVIN1-LC3B binding not biochemically resolved
    • Single-lab functional dissection
  10. 2020 Medium

    Linked CAV1 loss-of-function to ALS through enhancer variants that reduce CAV1/CAV2 expression and disrupt membrane lipid rafts.

    Evidence Rare variant burden analysis, patient-derived cells, and CRISPR-Cas9 enhancer perturbation in neurons

    PMID:33264630

    Open questions at the time
    • Downstream neuronal MLR targets mediating ALS pathology undefined
    • Causal mutation effect inferred from proximate CRISPR edit
  11. 2020 Medium

    Reinforced CAV1's reciprocal regulation of eNOS/NO in Schlemm's canal endothelium, showing ABCA1 modulates outflow resistance by tuning CAV1 levels.

    Evidence Bidirectional ABCA1 manipulation with TEER, NO measurement, and in vivo intracameral injection

    PMID:32428234

    Open questions at the time
    • Mechanism by which ABCA1 controls CAV1 expression not defined
    • Single-lab study
  12. 2021 Medium

    Established CAV1 as strictly required for caveolae biogenesis and for stability of CAV2 and CAVIN1, with biallelic null variants causing congenital generalized lipodystrophy.

    Evidence NGS, western blotting of patient fibroblasts, and electron microscopy of caveolae across two independent patients

    PMID:34643546

    Open questions at the time
    • Molecular basis of insulin resistance and premature senescence downstream of caveolae loss not dissected
    • Order of partner destabilization not resolved
  13. 2024 High

    Revealed a novel CAV1 trafficking role, marking intraluminal vesicles delivered to migrasomes via a Rab10/Myosin Va/RILPL2 pathway under LRRK2 control to drive macrophage differentiation.

    Evidence Live imaging, Co-IP, knockdown of motor/adaptor proteins, LRRK2 kinase assays, and macrophage differentiation readouts

    PMID:39008679

    Open questions at the time
    • How CAV1 selects intraluminal vesicle cargo not defined
    • Relationship of this trafficking route to canonical caveolae unclear

Open questions

Synthesis pass · forward-looking unresolved questions
  • The unifying basis for CAV1's opposing context-dependent roles — pro- versus anti-tumorigenic, and how its scaffolding, autophagy, eNOS regulation, and migrasome trafficking functions interrelate at the molecular level — remains unresolved.
  • No structural model reconciling scaffolding-domain interactions across partners
  • Determinants of tissue/context-specific CAV1 function not identified

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0098772 molecular function regulator activity 4 GO:0008289 lipid binding 2 GO:0060090 molecular adaptor activity 2 GO:0005198 structural molecule activity 1
Localization
GO:0005886 plasma membrane 3 GO:0005829 cytosol 1 GO:0031410 cytoplasmic vesicle 1
Pathway
R-HSA-162582 Signal Transduction 4 R-HSA-5653656 Vesicle-mediated transport 2 R-HSA-9612973 Autophagy 2 R-HSA-1852241 Organelle biogenesis and maintenance 1
Partners
BECN1CAV2CAVIN1EGFRLC3BPTPN1RAB10SRC
Complex memberships
caveolae

Evidence

Reading pass · 16 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2006 CAV1 is a direct transcriptional target of EWS/FLI-1 in Ewing's sarcoma cells. CAV1 knockdown upregulated Snail and caused loss of E-cadherin expression, while CAV1 knockdown inhibited anchorage-independent growth and tumor formation in xenografts. Re-expression of CAV1 or E-cadherin rescued the oncogenic phenotype, defining a CAV1/Snail/E-cadherin pathway downstream of EWS/FLI-1. Antisense and shRNA knockdown, chromatin immunoprecipitation, array analyses, re-expression studies, nude mouse xenografts Cancer research High 17047056
2017 Phosphorylation of CAV1 at tyrosine-14 is required for its interaction with the BECN1/VPS34 complex through CAV1's scaffolding domain. This interaction promotes autophagosome formation and autophagy flux under oxidative stress. The phosphatase PTPN1 dephosphorylates CAV1-Y14 and inhibits this autophagy activation. In Cav1 knockout mice, autophagy was impaired and cerebral infarct damage was aggravated. Co-immunoprecipitation, site-directed mutagenesis (Y14), PTPN1 phosphatase overexpression, Cav1 KO mouse model, LC3 foci imaging Cell death & disease High 28542134
2019 High glucose suppresses the AMPK-MTOR-PIK3C3 pathway, reducing autophagic degradation of CAV1. This causes CAV1 accumulation in the cytosol, increased caveolae formation at the cell membrane, and enhanced LDL transcytosis across endothelial cells. The CAV1-CAVIN1-LC3B axis mediates autophagic degradation of CAV1 under basal conditions. Autophagy flux assays, AMPK-MTOR pathway inhibition, CAV1 overexpression/knockdown, LDL transcytosis assay, gestational diabetes mellitus patient tissue analysis Autophagy Medium 31448673
2016 Desmoglein 2 (Dsg2) overexpression displaces CAV1, EGFR, and c-Src from light-density lipid raft fractions. CAV1 functions as part of a lipid raft signaling platform: perturbation of lipid rafts (by MβCD cholesterol chelation) shifts CAV1, c-Src, and EGFR out of rafts and activates downstream signaling. Dsg2 stimulates EGFR activation and cell proliferation/migration through a c-Src and CAV1-dependent mechanism using lipid rafts. Sucrose density fractionation, STED super-resolution imaging, Dsg2 knockdown/overexpression, MβCD treatment Oncotarget Medium 26918609
2014 CAV1 promotes HCC cell invasion and metastasis by inducing epithelial-mesenchymal transition (EMT) through the Wnt/β-catenin pathway. CAV1 also acts as a mediator between hyperactive ERK1/2 signaling and transcription of MMP-7, identifying MMP-7 as a novel downstream target of CAV1. CAV1 overexpression and stable knockdown, in vitro invasion assays, in vivo xenograft and lung metastasis models, tissue microarray immunohistochemistry PloS one Medium 25180681
2018 PTBP3 interacts with the CU-rich region of the CAV1 gene to downregulate CAV1α expression via alternative splicing. Knockdown of CAV1α abrogated the reduction of FAK and Src phosphorylation induced by PTBP3 knockdown, placing CAV1α downstream of PTBP3 in a gastric cancer metastasis pathway. RNA immunoprecipitation (RIP), dual-luciferase reporter assays, PTBP3 overexpression/knockdown, xenotransplant mouse model Cell death & disease Medium 29752441
2015 A de novo heterozygous frame-shift mutation in CAV1 (p.Phe160X) causes a severe neonatal progeroid and lipodystrophy syndrome. Western blotting of patient fibroblasts showed significantly decreased wild-type CAV1 protein, demonstrating a loss-of-function mechanism. RNA sequencing showed dysregulation of pathways related to apoptosis, DNA repair/replication, and mitochondrial function, and significant down-regulation of known CAV1 interaction partners. Whole-genome sequencing, RNA-seq, western blotting of patient fibroblasts PloS one Medium 26176221
2016 CAV1 knockout mice exhibit elevated intraocular pressure and reduced conventional outflow facility. CAV1 deficiency (and loss of CAV2) results in increased eNOS activity, as evidenced by increased eNOS, eNOS-phospho Ser1177, Akt, and nitrotyrosine, and decreased eNOS-phospho Thr495 levels. The IOP elevation may be mediated by increased tyrosine nitration of protein kinase K and impairment of its activity. CAV1 KO mouse model, rebound tonometry, western blot, topical NOS inhibitor/donor pharmacology, perfusion outflow facility measurement Investigative ophthalmology & visual science Medium 27228562
2014 CAV1 deletion in mice impairs hematopoietic stem cell (HSC) function. Cav-1-/- mice show increased numbers of LSK cells and LT-HSCs with age, but LT-HSCs have reduced self-renewal capacity in vitro and fail to reconstitute hematopoiesis in competitive transplantation assays. CAV1 deletion disrupts quiescence of LSKs and promotes cell cycle progression through G2/M phase. Cav-1 KO mouse model, FACS analysis, in vitro clonogenic assay, in vivo competitive transplantation, cell cycle analysis Cell death & disease Medium 24675458
2018 CAV1 deficiency activates JNK-associated signaling (MKK7/JNK pathway) in vascular smooth muscle cells. Cav-1-/- in ApoE-/- mice attenuated high-fat diet-induced atherosclerotic lesions, reduced macrophage content and pro-inflammatory cytokines, inactivated IKKβ/p65/IκBα signaling, and reduced MKK7/JNK activity. In vitro, JNK activation abolished the anti-atherosclerotic effects of CAV1 knockdown in ox-LDL-treated VSMCs, placing CAV1 upstream of JNK in atherosclerosis. Cav-1-/- ApoE-/- mouse model, western blot, RT-qPCR, Oil Red O staining, JNK activator rescue in vitro Biochemical and biophysical research communications Medium 29746866
2015 IFITM1 promotes colorectal cancer cell invasion with CAV1 acting as a downstream target. Knockdown of CAV1 abrogated the siIFITM1-mediated inhibition of cell invasion in CRC cells, placing CAV1 downstream of IFITM1 in invasion regulation. IFITM1 overexpression/knockdown, CAV1 knockdown epistasis experiment, cell migration/invasion assays Cancer letters Low 26259513
2022 In colorectal cancer, CD26 promotes metastasis through upregulation of MMP1; overexpression of CAV1 abrogated CD26-regulated MMP1 induction in CRC cell lines, placing CAV1 as a negative regulator of MMP1 expression downstream of CD26 signaling. CD26 overexpression/repression, CAV1 overexpression epistasis, genome-wide mRNA expression array, qPCR, in vivo mouse models International journal of molecular sciences Low 35163100
2021 Biallelic CAV1 null variants (homozygous loss-of-function) cause congenital generalized lipodystrophy (CGL3). Patient fibroblasts show complete loss of caveolae, absent caveolin-1 protein, and concomitant loss of caveolin-2 and cavin-1 partners, demonstrating that CAV1 is required for caveolae formation and for stability of its partner proteins CAVIN1 and CAV2. Patient fibroblasts also displayed insulin resistance, increased oxidative stress, and premature senescence. Next-generation sequencing, western blotting of patient fibroblasts, electron microscopy of caveolae, clinical/metabolic phenotyping European journal of endocrinology Medium 34643546
2024 CAV1 marks intraluminal vesicles destined for migrasomes, co-localizing with Rab10. Transport of Rab10-CAV1 vesicles to migrasomes requires the motor protein Myosin Va and adaptor proteins RILPL2. Phosphorylation of Rab10 by the kinase LRRK2 regulates this transport process. CSF-1 is transported to migrasomes via this CAV1-dependent mechanism to foster monocyte-macrophage differentiation. Live imaging, co-immunoprecipitation, dominant-negative/knockdown experiments for Myosin Va and RILPL2, LRRK2 kinase assay/inhibition, wound healing macrophage differentiation assay Proceedings of the National Academy of Sciences of the United States of America High 39008679
2020 Rare variants in CAV1/CAV2 enhancers are enriched in ALS patients. Patient-derived enhancer mutations reduce CAV1/CAV2 expression and disrupt membrane lipid rafts (MLRs). CRISPR-Cas9 perturbation proximate to a patient mutation was sufficient to reduce CAV1/CAV2 expression in neurons, establishing a loss-of-function mechanism for CAV1 in ALS via disruption of MLRs. Rare variant burden analysis, patient-derived cell studies, CRISPR-Cas9 perturbation in neurons, MLR functional assay Cell reports Medium 33264630
2020 ABCA1 upregulation in Schlemm's canal endothelial cells decreases CAV1 expression (~0.56-fold) and increases eNOS expression and NO production, reducing transendothelial resistance. Conversely, ABCA1 downregulation increases CAV1 expression and decreases eNOS/NO. This establishes that CAV1 negatively regulates eNOS/NO signaling in the aqueous humor outflow pathway. ABCA1 agonist (GW3965) treatment, lentiviral ABCA1 shRNA knockdown, western blot, transendothelial electrical resistance measurement, NO concentration measurement, intracameral injection in vivo Investigative ophthalmology & visual science Medium 32428234

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2005 Role of hippocampal Cav1.2 Ca2+ channels in NMDA receptor-independent synaptic plasticity and spatial memory. The Journal of neuroscience : the official journal of the Society for Neuroscience 357 16251435
2014 L-type CaV1.2 calcium channels: from in vitro findings to in vivo function. Physiological reviews 285 24382889
2012 CACNA1C (Cav1.2) in the pathophysiology of psychiatric disease. Progress in neurobiology 226 22705413
2005 G-protein-coupled receptor modulation of striatal CaV1.3 L-type Ca2+ channels is dependent on a Shank-binding domain. The Journal of neuroscience : the official journal of the Society for Neuroscience 217 15689540
2020 Mechanism of adrenergic CaV1.2 stimulation revealed by proximity proteomics. Nature 202 31969708
2008 The Timothy syndrome mutation differentially affects voltage- and calcium-dependent inactivation of CaV1.2 L-type calcium channels. Proceedings of the National Academy of Sciences of the United States of America 142 18250309
2011 BIN1 is reduced and Cav1.2 trafficking is impaired in human failing cardiomyocytes. Heart rhythm 136 22138472
2005 Association of CaV1.3 L-type calcium channels with Shank. The Journal of neuroscience : the official journal of the Society for Neuroscience 124 15689539
2014 The role of L-type voltage-gated calcium channels Cav1.2 and Cav1.3 in normal and pathological brain function. Cell and tissue research 123 24996399
2006 Caveolin-1 (CAV1) is a target of EWS/FLI-1 and a key determinant of the oncogenic phenotype and tumorigenicity of Ewing's sarcoma cells. Cancer research 123 17047056
2010 CaV1.2 beta-subunit coordinates CaMKII-triggered cardiomyocyte death and afterdepolarizations. Proceedings of the National Academy of Sciences of the United States of America 106 20194790
2003 Cav1.4alpha1 subunits can form slowly inactivating dihydropyridine-sensitive L-type Ca2+ channels lacking Ca2+-dependent inactivation. The Journal of neuroscience : the official journal of the Society for Neuroscience 106 12853422
2014 Cav1.3 channels control D2-autoreceptor responses via NCS-1 in substantia nigra dopamine neurons. Brain : a journal of neurology 102 24934288
2004 Ser1928 is a common site for Cav1.2 phosphorylation by protein kinase C isoforms. The Journal of biological chemistry 101 15509562
2005 Splicing for alternative structures of Cav1.2 Ca2+ channels in cardiac and smooth muscles. Cardiovascular research 100 16051206
2007 Protein kinase G phosphorylates Cav1.2 alpha1c and beta2 subunits. Circulation research 95 17626895
2004 Ca2+-binding protein-1 facilitates and forms a postsynaptic complex with Cav1.2 (L-type) Ca2+ channels. The Journal of neuroscience : the official journal of the Society for Neuroscience 94 15140941
2006 Ca1.2 and CaV1.3 neuronal L-type calcium channels: differential targeting and signaling to pCREB. The European journal of neuroscience 88 16706838
2016 L-type Cav1.3 channels regulate ryanodine receptor-dependent Ca2+ release during sino-atrial node pacemaker activity. Cardiovascular research 81 26786159
2006 Integrin receptor activation triggers converging regulation of Cav1.2 calcium channels by c-Src and protein kinase A pathways. The Journal of biological chemistry 81 16554304
2009 CaV1.2 channelopathies: from arrhythmias to autism, bipolar disorder, and immunodeficiency. Pflugers Archiv : European journal of physiology 77 19916019
2012 CaV1.2 signaling complexes in the heart. Journal of molecular and cellular cardiology 73 23266596
2019 CAV1-CAVIN1-LC3B-mediated autophagy regulates high glucose-stimulated LDL transcytosis. Autophagy 72 31448673
2015 IFITM1 promotes the metastasis of human colorectal cancer via CAV-1. Cancer letters 71 26259513
2014 Basal and β-adrenergic regulation of the cardiac calcium channel CaV1.2 requires phosphorylation of serine 1700. Proceedings of the National Academy of Sciences of the United States of America 66 25368181
2009 Developmental control of CaV1.2 L-type calcium channel splicing by Fox proteins. Molecular and cellular biology 66 19564422
2013 Cav1.3 channel α1D protein is overexpressed and modulates androgen receptor transactivation in prostate cancers. Urologic oncology 62 24054868
2007 Apical GLUT2 and Cav1.3: regulation of rat intestinal glucose and calcium absorption. The Journal of physiology 62 17272350
2017 Phosphorylated CAV1 activates autophagy through an interaction with BECN1 under oxidative stress. Cell death & disease 60 28542134
2012 Exploring the dominant role of Cav1 channels in signalling to the nucleus. Bioscience reports 60 23088728
2018 Postsynaptic localization and regulation of AMPA receptors and Cav1.2 by β2 adrenergic receptor/PKA and Ca2+/CaMKII signaling. The EMBO journal 57 30249603
2003 Enhanced expression of L-type Cav1.3 calcium channels in murine embryonic hearts from Cav1.2-deficient mice. The Journal of biological chemistry 57 12900400
2016 c-Src/Cav1-dependent activation of the EGFR by Dsg2. Oncotarget 53 26918609
2019 Cardiac CaV1.2 channels require β subunits for β-adrenergic-mediated modulation but not trafficking. The Journal of clinical investigation 52 30422117
2019 TDP-43 regulates early-phase insulin secretion via CaV1.2-mediated exocytosis in islets. The Journal of clinical investigation 52 31355778
2014 Characterization of Cav1.4 complexes (α11.4, β2, and α2δ4) in HEK293T cells and in the retina. The Journal of biological chemistry 52 25468907
2009 PIKfyve regulates CaV1.2 degradation and prevents excitotoxic cell death. The Journal of cell biology 52 19841139
2019 Identification of CAV1 and DCN as potential predictive biomarkers for lung adenocarcinoma. American journal of physiology. Lung cellular and molecular physiology 50 30604627
2018 PTBP3 contributes to the metastasis of gastric cancer by mediating CAV1 alternative splicing. Cell death & disease 49 29752441
2014 Regulation of gene transcription by voltage-gated L-type calcium channel, Cav1.3. The Journal of biological chemistry 49 25538241
2020 Skeletal muscle CaV1.1 channelopathies. Pflugers Archiv : European journal of physiology 48 32222817
2013 Cav1.1 controls frequency-dependent events regulating adult skeletal muscle plasticity. Journal of cell science 48 23321639
2014 CAV1 promotes HCC cell progression and metastasis through Wnt/β-catenin pathway. PloS one 47 25180681
2004 Localization and modulation of {alpha}1D (Cav1.3) L-type Ca channel by protein kinase A. American journal of physiology. Heart and circulatory physiology 47 15615842
2016 Cav1.2 and Cav1.3 L-type calcium channels independently control short- and long-term sensitization to pain. The Journal of physiology 46 27231046
2012 CaV1.2 sparklets in heart and vascular smooth muscle. Journal of molecular and cellular cardiology 46 23220157
2017 Genomic upregulation of cardiac Cav1.2α and NCX1 by estrogen in women. Biology of sex differences 45 28807015
2016 Genomic variant in CAV1 increases susceptibility to coronary artery disease and myocardial infarction. Atherosclerosis 44 26775120
2015 Cell-type-specific tuning of Cav1.3 Ca(2+)-channels by a C-terminal automodulatory domain. Frontiers in cellular neuroscience 43 26379493
2010 Analysis of Cav1.2 and ryanodine receptor clusters in rat ventricular myocytes. Biophysical journal 43 21156134
2004 Muscarinic M2 receptor stimulation of Cav1.2b requires phosphatidylinositol 3-kinase, protein kinase C, and c-Src. Circulation research 43 14739158
2022 CD26 Induces Colorectal Cancer Angiogenesis and Metastasis through CAV1/MMP1 Signaling. International journal of molecular sciences 42 35163100
2020 Disruption of Cav1.2-mediated signaling is a pathway for ketamine-induced pathology. Nature communications 42 32859919
2019 Estrogen receptor α promotes Cav1.2 ubiquitination and degradation in neuronal cells and in APP/PS1 mice. Aging cell 40 31012223
2015 Ca(2+) permeation and/or binding to CaV1.1 fine-tunes skeletal muscle Ca(2+) signaling to sustain muscle function. Skeletal muscle 40 25717360
2015 CaV1.2/CaV3.x channels mediate divergent vasomotor responses in human cerebral arteries. The Journal of general physiology 40 25918359
2017 Increased Ca2+ signaling through CaV1.2 promotes bone formation and prevents estrogen deficiency-induced bone loss. JCI insight 39 29202453
2013 Mosaic synaptopathy and functional defects in Cav1.4 heterozygous mice and human carriers of CSNB2. Human molecular genetics 39 24163243
2015 Cav1.3 Channels as Key Regulators of Neuron-Like Firings and Catecholamine Release in Chromaffin Cells. Current molecular pharmacology 38 25966692
2015 A Frame-Shift Mutation in CAV1 Is Associated with a Severe Neonatal Progeroid and Lipodystrophy Syndrome. PloS one 38 26176221
2016 eNOS Activity in CAV1 Knockout Mouse Eyes. Investigative ophthalmology & visual science 35 27228562
2017 Ca2+ protein alpha 1D of CaV1.3 regulates intracellular calcium concentration and migration of colon cancer cells through a non-canonical activity. Scientific reports 34 29079724
2013 Protein kinase C-dependent activation of CaV1.2 channels selectively controls human TH2-lymphocyte functions. The Journal of allergy and clinical immunology 33 24365142
2016 Regulation of aldosterone secretion by Cav1.3. Scientific reports 32 27098837
2012 Equal sensitivity of Cav1.2 and Cav1.3 channels to the opposing modulations of PKA and PKG in mouse chromaffin cells. The Journal of physiology 32 22826131
2020 Cav1.2 channelopathies causing autism: new hallmarks on Timothy syndrome. Pflugers Archiv : European journal of physiology 31 32621084
2012 Cav1.3 and Cav1.2 channels of adrenal chromaffin cells: emerging views on cAMP/cGMP-mediated phosphorylation and role in pacemaking. Biochimica et biophysica acta 31 23159773
2006 The junctional SR protein JP-45 affects the functional expression of the voltage-dependent Ca2+ channel Cav1.1. Journal of cell science 31 16638807
2024 Key Roles of CACNA1C/Cav1.2 and CALB1/Calbindin in Prefrontal Neurons Altered in Cognitive Disorders. JAMA psychiatry 30 38776078
2016 An autism-associated mutation in CaV1.3 channels has opposing effects on voltage- and Ca(2+)-dependent regulation. Scientific reports 30 27255217
2014 Differential regulation of CaV1.2 channels by cAMP-dependent protein kinase bound to A-kinase anchoring proteins 15 and 79/150. The Journal of general physiology 30 24567507
2015 Homer proteins mediate the interaction between STIM1 and Cav1.2 channels. Biochimica et biophysica acta 29 25712868
2007 Regulation of Cav1.2 current: interaction with intracellular molecules. Journal of pharmacological sciences 29 17409629
2010 Spatial association of the Cav1.2 calcium channel with α5β1-integrin. American journal of physiology. Cell physiology 28 21178109
2021 Mechanisms and Regulation of Cardiac CaV1.2 Trafficking. International journal of molecular sciences 27 34072954
2020 Rare Variant Burden Analysis within Enhancers Identifies CAV1 as an ALS Risk Gene. Cell reports 27 33264630
2019 Genetic silencing of striatal CaV1.3 prevents and ameliorates levodopa dyskinesia. Movement disorders : official journal of the Movement Disorder Society 27 31002755
2024 Rab10-CAV1 mediated intraluminal vesicle transport to migrasomes. Proceedings of the National Academy of Sciences of the United States of America 26 39008679
2019 Calcium Signaling in Neurons and Glial Cells: Role of Cav1 channels. Neuroscience 26 31678346
2015 Cacna1c (Cav1.2) Modulates Electroencephalographic Rhythm and Rapid Eye Movement Sleep Recovery. Sleep 26 25845695
2020 ABCA1 Regulates IOP by Modulating Cav1/eNOS/NO Signaling Pathway. Investigative ophthalmology & visual science 25 32428234
2014 Cav-1 deletion impaired hematopoietic stem cell function. Cell death & disease 25 24675458
2018 Tissue-selective restriction of RNA editing of CaV1.3 by splicing factor SRSF9. Nucleic acids research 24 29733375
2018 Cav-1 promotes atherosclerosis by activating JNK-associated signaling. Biochemical and biophysical research communications 24 29746866
2006 Protein kinase C activation inhibits Cav1.3 calcium channel at NH2-terminal serine 81 phosphorylation site. American journal of physiology. Heart and circulatory physiology 24 16973824
2016 Protein kinase A modulation of CaV1.4 calcium channels. Nature communications 23 27456671
2015 Modulation of CaV1.2 calcium channel by neuropeptide W regulates vascular myogenic tone via G protein-coupled receptor 7. Journal of hypertension 22 26536090
2023 ANO1, CaV1.2, and IP3R form a localized unit of EC-coupling in mouse pulmonary arterial smooth muscle. The Journal of general physiology 21 37702787
2021 Cav1.4 dysfunction and congenital stationary night blindness type 2. Pflugers Archiv : European journal of physiology 21 34212239
2022 Bipolar-associated miR-499-5p controls neuroplasticity by downregulating the Cav1.2 subunit CACNB2. EMBO reports 20 35969184
2022 CAV1 alleviated CaOx stones formation via suppressing autophagy-dependent ferroptosis. PeerJ 20 36128191
2018 Inhibition of Cx43 attenuates ERK1/2 activation, enhances the expression of Cav‑1 and suppresses cell proliferation. International journal of molecular medicine 20 30132504
2016 Rescuing cardiac automaticity in L-type Cav1.3 channelopathies and beyond. The Journal of physiology 20 27374078
2024 CardioDPi: An explainable deep-learning model for identifying cardiotoxic chemicals targeting hERG, Cav1.2, and Nav1.5 channels. Journal of hazardous materials 19 38805819
2022 CaV1.2 channelopathic mutations evoke diverse pathophysiological mechanisms. The Journal of general physiology 19 36167061
2018 Cav1.2 L-type calcium channels regulate stress coping behavior via serotonin neurons. Neuropharmacology 19 30176250
2015 L-type Calcium Channel Cav1.2 Is Required for Maintenance of Auditory Brainstem Nuclei. The Journal of biological chemistry 19 26242732
2011 Perinatal and postnatal expression of Cav1.3 α1D Ca²⁺ channel in the rat heart. Pediatric research 19 21378599
2021 Biallelic CAV1 null variants induce congenital generalized lipodystrophy with achalasia. European journal of endocrinology 18 34643546
2006 Genetic analysis of CAV1 gene in hypertension and metabolic syndrome. Thrombosis and haemostasis 18 16601841

Missed literature

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