Affinage

RAB10

Ras-related protein Rab-10 · UniProt P61026

Length
200 aa
Mass
22.5 kDa
Annotated
2026-04-28
100 papers in source corpus 49 papers cited in narrative 48 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

RAB10 is a small GTPase that serves as a master regulator of membrane trafficking across diverse cellular contexts, directing vesicle translocation, endocytic recycling, organelle dynamics, and autophagy. In adipocytes, RAB10 acts downstream of the AS160/TBC1D4 GAP and is activated by the GEF Dennd4C to drive insulin-stimulated GLUT4 storage vesicle translocation to the plasma membrane, engaging effectors including Myosin-Va, the exocyst subunits Exoc6/Exoc6b, SEC16A, and the Ral-GEF Rlf/RalA cascade (PMID:17403373, PMID:21454697, PMID:22908308, PMID:26299925, PMID:25103239); in epithelial cells and neurons, RAB10 controls basolateral endocytic recycling (with EHBP-1), tubular endosome formation (via KIF13A/KIF13B), ER tubule dynamics, phagosome maturation, lipophagy (with EHBP1 and EHD2), TLR4 surface delivery, and anterograde axonal transport through a kinesin-1/JIP1 complex released by Lgl1-mediated GDI displacement (PMID:16394106, PMID:30700496, PMID:23263280, PMID:20028485, PMID:28028537, PMID:20643919, PMID:24478353, PMID:21856246). RAB10 is a principal substrate of the Parkinson's disease kinase LRRK2, which phosphorylates Thr73 in the switch-II motif; pathogenic LRRK2 mutations hyperphosphorylate RAB10, impairing its interaction with OPTN to block mitophagy and redirecting phospho-RAB10 to RILPL1/RILPL2 at mother centriole subdistal appendages to disrupt ciliogenesis and centrosomal cohesion (PMID:27474410, PMID:30945962, PMID:33653948, PMID:35776681). LRRK2-mediated RAB10 phosphorylation on lysosomes is spatially regulated by perinuclear lysosome positioning and opposed by the phosphatase PPM1H, and phospho-RAB10 interacts with VPS13C to mediate lysosomal stress responses in dopaminergic neurons (PMID:36256825, PMID:38358348).

Mechanistic history

Synthesis pass · year-by-year structured walk · 17 steps
  1. 1993 Medium

    The first subcellular characterization of RAB10 established that despite 66% sequence identity to RAB8, RAB10 localizes to distinct perinuclear/Golgi-associated membranes, raising the question of what trafficking pathway it controls.

    Evidence HA-epitope tagging and immunofluorescence in stably transfected CHO and BHK cells

    PMID:7688123

    Open questions at the time
    • No functional assay performed
    • Localization in polarized or physiologically relevant cells not assessed
  2. 2006 High

    Three concurrent studies established RAB10 as a regulator of polarized membrane trafficking: it controls basolateral endocytic recycling in C. elegans intestine (upstream of RME-1), mediates sorting at basolateral endosomes in MDCK cells, and cooperates with RAB8a in Golgi-to-basolateral biosynthetic transport, defining RAB10 as a key GTPase for polarized epithelial trafficking.

    Evidence Null mutant analysis with cargo tracking in C. elegans; dominant-negative/constitutively active mutants with quantitative endocytic probes in MDCK cells; double-knockdown epistasis with RAB8a

    PMID:16394106 PMID:16641372 PMID:17132146

    Open questions at the time
    • Mammalian loss-of-function in vivo not yet performed
    • Effectors mediating these epithelial functions unidentified
  3. 2007 High

    The critical question of which Rab GTPase transduces insulin/AS160 signaling to GLUT4 vesicles was answered: RAB10 was identified as the specific downstream target of AS160/TBC1D4 GAP required for insulin-stimulated GLUT4 translocation in adipocytes.

    Evidence siRNA knockdown of individual Rab candidates, dominant-active mutant rescue, dual-knockdown epistasis in 3T3-L1 adipocytes

    PMID:17403373 PMID:18076383

    Open questions at the time
    • Upstream GEF for RAB10 in insulin signaling unknown at this point
    • Mechanism of vesicle docking/fusion downstream of RAB10 unresolved
  4. 2009 High

    RAB10 was shown to participate in innate immune membrane dynamics: it transiently associates with early phagosomes and promotes phagosome maturation, with constitutively active RAB10 partially rescuing maturation of Mycobacterium-arrested phagosomes.

    Evidence Gain- and loss-of-function RAB10 mutants with live-Mycobacterium infection assays and EEA1 acquisition imaging

    PMID:20028485

    Open questions at the time
    • Direct effectors on phagosomal membrane not identified
    • Whether LRRK2 regulates RAB10 on phagosomes unknown
  5. 2010 High

    Two functional axes were extended: RAB10 was shown to deliver TLR4 from Golgi to the plasma membrane in macrophages (with in vivo validation in acute lung injury), and the effector EHBP-1 was identified as a RAB10 binding partner required for endocytic recycling in C. elegans.

    Evidence Dominant-negative/siRNA in macrophages with in vivo mouse model; yeast two-hybrid identification of EHBP-1 with genetic phenocopy in C. elegans

    PMID:20573983 PMID:20643919

    Open questions at the time
    • Whether EHBP-1/EHBP1 functions are conserved in mammalian recycling not tested
    • TLR4 trafficking mechanism beyond RAB10 involvement unclear
  6. 2011 High

    Three mechanistic advances refined RAB10 activation and effector logic: Dennd4C was identified as the GEF activating RAB10 for GLUT4 translocation; Lgl1 was shown to release GDI from RAB10 to enable its membrane recruitment during axonal polarization; and Myosin-Va was confirmed as a RAB10 interactor (via exon D) connecting RAB10 vesicles to actin-based transport.

    Evidence siRNA phenocopy of Rab10 KD by Dennd4C KD in adipocytes; GDI release assay and in vivo cortical electroporation; yeast two-hybrid and FRET for Myosin V interaction domain mapping

    PMID:19008234 PMID:21454697 PMID:21856246

    Open questions at the time
    • How insulin regulates Dennd4C activity is unknown
    • Structural basis of Lgl1-mediated GDI displacement not resolved
  7. 2012 High

    RAB10 was established as an ER-resident Rab controlling tubular ER dynamics and phospholipid synthesis domain formation, revealing a function beyond endosomal/vesicular trafficking; simultaneously, TIRF imaging directly visualized RAB10-dependent GLUT4 vesicle docking at the plasma membrane via Myosin-Va.

    Evidence Live-cell ER imaging with siRNA and GDP-locked mutant; dual-color TIRF with IRAP-pHluorin fusion assay in adipocytes

    PMID:22908308 PMID:23263280

    Open questions at the time
    • ER tubule effectors downstream of RAB10 not identified
    • Whether ER and GLUT4 functions are coordinated is unknown
  8. 2014 High

    Multiple effector complexes were defined: kinesin-1/JIP1/RAB10 was shown to drive anterograde axonal transport of plasmalemmal precursor vesicles; MARCKS was identified as a phosphorylation-dependent RAB10 effector mediating vesicle–plasma membrane fusion during axon growth; RAB10 activated RalA via Rlf/Rgl2 in a GTPase cascade for GLUT4 translocation; and the exocyst/RAB-10/SEC-10 axis was placed in basolateral recycling in C. elegans.

    Evidence Co-IP and live axonal transport imaging with in vivo cortical electroporation; TIRF vesicle fusion assays; GTPase cascade rescue experiments; epistasis and EM in C. elegans intestine

    PMID:24478353 PMID:24662485 PMID:25103239 PMID:25301900

    Open questions at the time
    • Whether JIP1 and MARCKS pathways converge on the same vesicle population unclear
    • RalA cascade not independently confirmed
  9. 2015 Medium

    RAB10-mediated recruitment of the RAB-5 GAP TBC-2 (with amphiphysin AMPH-1) was identified as the mechanism for RAB-5 downregulation on endosomes, explaining how cargo exits early endosomes during recycling.

    Evidence Genetic epistasis, colocalization, and cargo tracking in C. elegans

    PMID:26393361

    Open questions at the time
    • Mammalian conservation of RAB10–TBC-2/AMPH-1 axis not demonstrated
    • Whether this mechanism operates in all RAB10 recycling contexts untested
  10. 2016 High

    A paradigm shift occurred when LRRK2 was shown to directly phosphorylate RAB10 at Thr73 in the switch-II motif, with pathogenic LRRK2 mutations causing hyperphosphorylation—establishing RAB10 as a central LRRK2 substrate linking Parkinson's disease genetics to Rab-dependent membrane trafficking.

    Evidence Phos-tag electrophoresis in kinase-dead knockin mouse models, LRRK2 kinase inhibitor treatment, multiple genetic models

    PMID:27474410

    Open questions at the time
    • Downstream consequences of pT73-Rab10 for trafficking not yet determined
    • Which cell types in the brain are most affected unclear
  11. 2016 High

    RAB10 was shown to drive lipophagy through a complex with EHBP1 and the membrane-deforming ATPase EHD2, recruited to nascent autophagic membranes engulfing lipid droplets in hepatocytes.

    Evidence siRNA knockdown, GTPase-defective mutant, Co-IP identifying RAB10–EHBP1–EHD2 complex, LC3 recruitment assay

    PMID:28028537

    Open questions at the time
    • Whether LRRK2 phosphorylation modulates lipophagy via RAB10 not tested
    • GEF activating RAB10 for lipophagy unknown
  12. 2019 High

    The pathological consequences of LRRK2-mediated RAB10 phosphorylation were mechanistically resolved in two directions: pT73-RAB10 impairs interaction with OPTN to block PINK1/PRKN-dependent mitophagy, and pT73-RAB10 is recruited to centrosomal RILPL1 causing ciliogenesis defects and centrosomal cohesion loss—both observed in patient-derived cells.

    Evidence Co-IP and phosphomimetic mutants with depolarization-induced mitophagy in patient cells; phospho-specific antibodies and LRRK2 inhibitor rescue in patient-derived peripheral cells and mutant LRRK2 mouse astrocytes

    PMID:30945962 PMID:31428781

    Open questions at the time
    • Whether mitophagy and ciliogenesis defects contribute differentially to PD pathogenesis is unknown
    • In vivo neuronal validation of ciliogenesis pathway incomplete
  13. 2019 High

    RAB10 was found to interact with kinesin motors KIF13A and KIF13B to generate tubular endosomes; CRISPR knockout of RAB10 completely abolished tubular endosomal structures.

    Evidence CRISPR knockout in HeLaM cells, domain truncation analysis of KIF13A

    PMID:30700496

    Open questions at the time
    • Cargo specificity of RAB10-dependent tubular endosomes not defined
    • Relationship to EHBP1L1-mediated recycling tubules not clarified
  14. 2020 High

    RAB10 was shown to selectively regulate macropinocytosis in immune cells, with LRRK2 phosphorylation blocking EHBP1L1-mediated recycling tubule formation and thereby stalling macropinosome cargo recycling to amplify PI3K-Akt signaling.

    Evidence siRNA in primary mouse and human macrophages/microglia, LRRK2 kinase inhibition, EHBP1L1 competitive overexpression

    PMID:32853409

    Open questions at the time
    • Whether macropinocytosis defects contribute to neuroinflammation in PD not tested in vivo
    • Specific cargo affected by recycling block not comprehensively catalogued
  15. 2021 High

    The ciliogenesis mechanism was refined: LRRK2 kinase activity blocks CP110 release from the mother centriole by preventing TTBK2 recruitment in a RAB10/RILPL1-dependent manner; separately, pT73-RAB10 sequesters Myosin-Va with RILPL2 at the peri-centriolar region, establishing two parallel phospho-RAB10 effector pathways at centrosomes.

    Evidence Live-cell imaging in R1441C MEFs, RAB10 and RILPL1 KO cells; Co-IP and FLIP microscopy with phospho-specific pulldowns

    PMID:33653948 PMID:33727250

    Open questions at the time
    • Whether RILPL1 and RILPL2 pathways are redundant or additive not fully resolved
    • Structural basis of pT73-RAB10 selectivity for RILPL1 vs RILPL2 unknown
  16. 2022 High

    The spatial regulation of LRRK2-RAB10 signaling was elucidated: pRab10 is restricted to perinuclear lysosomes, and lysosomal positioning controls phosphorylation via molecular proximity rather than kinase activation; the phosphatase PPM1H opposes this phosphorylation.

    Evidence LRRK2 lysosome-targeting constructs, ARL8B/SKIP overexpression, RILP overexpression, PPM1H knockdown with phospho-specific imaging

    PMID:36256825

    Open questions at the time
    • How lysosomal positioning is itself regulated in disease states is unclear
    • Whether PPM1H directly dephosphorylates pRab10 on lysosomal membranes not shown biochemically
  17. 2024 High

    Two new phospho-RAB10 effector pathways were defined: VPS13C was identified as a pRab10 interactor on lysosomes in iPSC-derived dopaminergic neurons mediating lysosomal stress responses, and pRab10 was shown to direct Myosin-Va/RILPL2-dependent transport of intraluminal vesicles to migrasomes for CSF-1 delivery during wound healing.

    Evidence Live-cell microscopy in iPSC-derived dopaminergic neurons with VPS13C KO; Co-IP and LRRK2 inhibition in migrasome transport assays with wound-healing model

    PMID:38358348 PMID:39008679

    Open questions at the time
    • Whether VPS13C–pRab10 interaction is disrupted in PD patient neurons not shown
    • Migrasome pathway not validated in vivo in disease models

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key unresolved questions include: how RAB10's diverse trafficking functions (GLUT4, ER tubules, recycling endosomes, phagosomes, autophagosomes, lysosomes, migrasomes) are coordinated or compartmentalized within a single cell; whether LRRK2-mediated phosphorylation modulates RAB10 functions beyond ciliogenesis, mitophagy, macropinocytosis, and lysosomal stress; and what structural features of pT73-RAB10 dictate selective effector engagement (RILPL1 vs RILPL2 vs OPTN vs VPS13C).
  • No structural model of pT73-RAB10 effector selectivity
  • Tissue-specific RAB10 knockout phenotypes in mammals largely uncharacterized
  • Integration of LRRK2-dependent and LRRK2-independent RAB10 functions not systematically addressed

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0003924 GTPase activity 6 GO:0008092 cytoskeletal protein binding 6
Localization
GO:0031410 cytoplasmic vesicle 6 GO:0005768 endosome 5 GO:0005794 Golgi apparatus 4 GO:0005815 microtubule organizing center 4 GO:0005886 plasma membrane 3 GO:0005764 lysosome 2 GO:0005783 endoplasmic reticulum 1
Pathway
R-HSA-5653656 Vesicle-mediated transport 11 R-HSA-9609507 Protein localization 5 R-HSA-1266738 Developmental Biology 4 R-HSA-162582 Signal Transduction 4 R-HSA-1643685 Disease 4 R-HSA-1852241 Organelle biogenesis and maintenance 4 R-HSA-168256 Immune System 3 R-HSA-382551 Transport of small molecules 3 R-HSA-9612973 Autophagy 3
Partners
EHBP1KIF13ALRRK2MAPK8IP1MYO5AOPTNRILPL1RILPL2
Complex memberships
Rab10/EHBP1/EHD2 lipophagy complexexocyst complexkinesin-1/JIP1/Rab10 transport complex

Evidence

Reading pass · 48 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2007 Rab10 functions as a downstream target of the AS160 (TBC1D4) Rab GTPase-activating protein in insulin signaling; Rab10 knockdown attenuates insulin-induced GLUT4 redistribution to the plasma membrane and reduces GLUT4 exocytosis rate, while a GTP-hydrolysis-defective Rab10 mutant increases plasma-membrane GLUT4 in basal adipocytes. Knockdown of Rab10 partially blocks the basal increase in surface GLUT4 caused by AS160 knockdown, placing Rab10 downstream of AS160. siRNA knockdown, dominant-active/dominant-negative mutant overexpression, re-expression rescue, dual-knockdown epistasis in 3T3-L1 adipocytes Cell metabolism High 17403373
2008 Among Rab8A, Rab8B, Rab10, and Rab14 (all AS160 GAP substrates present in GLUT4 vesicles), only Rab10 knockdown inhibited GLUT4 translocation in 3T3-L1 adipocytes; ~5% of total Rab10 resides in GLUT4 vesicles isolated from low-density microsomes; ~90% of Rab10 is in the GDP-bound (inactive) state in both basal and insulin-stimulated conditions. siRNA knockdown of individual Rab candidates, subcellular fractionation, pull-down GTP-loading assay The Biochemical journal High 18076383
2011 Dennd4C is identified as the guanine nucleotide exchange factor (GEF) for Rab10 required for insulin-stimulated GLUT4 translocation; Dennd4C is present in isolated GLUT4 vesicles, and its knockdown markedly inhibits GLUT4 translocation, phenocopying Rab10 knockdown. siRNA knockdown, subcellular fractionation, ectopic expression in 3T3-L1 adipocytes The Journal of biological chemistry High 21454697
2012 Rab10 directly facilitates GLUT4 storage vesicle (GSV) translocation to and docking at the plasma membrane, as visualized by dual-color TIRF microscopy and IRAP-pHluorin fusion assay; Myosin-Va associates with GSVs by interacting with Rab10, positioning peripherally recruited GSVs for ultimate fusion. Rab14 and Rab4/Rab8 regulate distinct, earlier endosomal recycling steps. Dual-color TIRF microscopy, IRAP-pHluorin fusion assay, co-immunoprecipitation, siRNA knockdown The Journal of cell biology High 22908308
2015 Rab10 in its GTP-bound form binds to exocyst subunits Exoc6 and Exoc6b; knockdown of either Exoc6 or Exoc6b inhibits insulin-stimulated GLUT4 translocation in 3T3-L1 adipocytes, linking Rab10-GTP to the tethering machinery. GTP-Rab10 pulldown, co-immunoprecipitation, siRNA knockdown in 3T3-L1 adipocytes Biochemical and biophysical research communications Medium 26299925
2016 SEC16A is a novel RAB10 effector required for insulin-stimulated GLUT4 translocation; SEC16A colocalizes with RAB10 in a perinuclear recycling endosome/TGN compartment, co-localization is augmented by insulin, and SEC16A knockdown phenocopies RAB10 knockdown. RAB10-SEC16A promotes mobilization of GLUT4 from a perinuclear compartment, acting independently of canonical COPII function. Co-localization imaging, siRNA knockdown, phenotypic rescue, vesicle fractionation in adipocytes The Journal of cell biology Medium 27354378
2014 Rab10 interacts with RalA through recruitment of the Ral-GEF Rlf/Rgl2; active Rab10 increases RalA-GTP levels, and Rab10 and RalA co-reside in GLUT4-storage vesicles. Membrane-tethered Rlf compensates for Rab10 loss in GLUT4 translocation, placing RalA downstream of Rab10 in a G protein cascade governing insulin-stimulated glucose uptake. Pulldown assays, GTPase activation assays, rescue by constitutively membrane-targeted Rlf, siRNA knockdown in adipocytes Molecular biology of the cell Medium 25103239
2020 The TBC1D4-RAB10 signaling module controls GLUT4 mobilization specifically from a trans-Golgi network (TGN) storage compartment; RAB10 is required for insulin-stimulated release from this intracellular sequestration site, and this function is distinct from copper-elicited ATP7A mobilization from the same TGN domain. siRNA/shRNA knockdown, live-cell imaging, cargo-specific stimulation experiments in adipocytes Molecular biology of the cell Medium 33175605
2012 Rab10 is an ER-specific Rab GTPase that localizes to dynamic ER-associated structures tracking along microtubules; depletion or GDP-locked Rab10 mutant reduces ER tubules by impairing tubule outgrowth and fusion. Rab10 partitions to leading-edge ER domains enriched in phospholipid synthesis enzymes PIS and CEPT1; GDP-locked Rab10 inhibits formation and function of these Rab10/PIS/CEPT1 domains. Live-cell fluorescence microscopy, siRNA knockdown, dominant-negative mutant expression, colocalization with ER markers Nature cell biology High 23263280
2006 In C. elegans intestinal epithelial cells, RAB-10 is required for basolateral endocytic recycling upstream of RME-1; rab-10 null mutants accumulate enlarged RAB-5-positive early endosomes, lose RME-1-positive recycling endosomes, and trap basolaterally recycling transmembrane cargo and fluid. GFP-RAB-10 localizes to endosomes and Golgi. Null mutant analysis, genetic epistasis, fluorescent reporter localization, cargo trafficking assays in C. elegans intestine Molecular biology of the cell High 16394106
2006 In polarized MDCK cells, Rab10 is associated with common/sorting endosomes accessible from both apical and basolateral surfaces; dominant-negative and constitutively active Rab10 mutants increase recycling from basolateral sorting endosomes to common endosomes, without affecting apical recycling or later recycling compartments. Quantitative confocal microscopy of GFP-Rab10 mutants, endocytic probe internalization from both surfaces Molecular biology of the cell High 16641372
2006 Rab10 localizes to Golgi during early polarization of MDCK cells; activated Rab10 mutant inhibits biosynthetic transport from the Golgi and missorts basolateral cargo to the apical membrane; simultaneous inhibition of Rab10 and Rab8a more strongly impairs basolateral sorting, indicating functional cooperation. GFP-tagged mutant expression, RNAi, immunofluorescence, biosynthetic transport assays in MDCK cells Traffic High 17132146
2010 Rab10 regulates continuous replenishment of TLR4 from Golgi to the plasma membrane in macrophages; blockade of Rab10 decreases surface TLR4, diminishes LPS-induced inflammatory cytokine and interferon production, and reduces disease severity in an in vivo LPS-induced acute lung injury model. Dominant-negative and siRNA-based Rab10 inhibition, surface TLR4 measurement, cytokine ELISAs, in vivo mouse model Proceedings of the National Academy of Sciences of the United States of America High 20643919
2008 Rab10 interacts with myosin Va, Vb, and Vc tails; this interaction requires the alternatively spliced exon D in myosin Va and Vb (and homologous region in Vc). Confirmed by yeast two-hybrid and FRET in vivo; Rab8a and Rab10 are mislocalized by dominant-negative myosin V tails. Yeast two-hybrid, FRET, dominant-negative myosin V tail overexpression, colocalization The Journal of biological chemistry High 19008234
2013 Myosin Vb interaction with Rab10 (via exon D-encoded domain) determines biogenesis of Rab10-positive post-Golgi carriers; blocking MYO5B-Rab10 interaction impairs fission of Rab10 vesicles from trans-Golgi membranes, reduces transport carrier number, and inhibits axon development in hippocampal neurons and in vivo in vertebrate neocortical neurons and zebrafish retinal ganglion cells. Co-immunoprecipitation, dominant-negative constructs, shRNA knockdown, live imaging, in vivo analysis in rat and zebrafish Nature communications High 23770993
2011 Lgl1 activates Rab10 by releasing GDP dissociation inhibitor (GDI) from Rab10; Lgl1 associates with plasmalemmal precursor vesicles (PPVs) and is enriched in developing axons. Rab10 lies downstream of Lgl1 in axon development and directional membrane insertion; both are required for neocortical neuronal polarization in vivo. Co-immunoprecipitation, GDI release assay, shRNA knockdown, epistasis by rescue, in vivo cortical electroporation Developmental cell High 21856246
2014 JIP1 (MAPK8IP1) interacts with GTP-locked active Rab10 and directly connects Rab10 to kinesin-1 light chain (KLC), forming a kinesin-1/JIP1/Rab10 complex required for anterograde transport of PPVs during axonal growth; disruption of any component reduces anterograde PPV transport and causes neuronal polarity defects in vitro and in vivo. Co-immunoprecipitation, dominant-negative/constitutively active Rab10 variants, shRNA knockdown, live axonal transport imaging, in vivo cortical electroporation The Journal of neuroscience High 24478353
2014 MARCKS (myristoylated alanine-rich C-kinase substrate) binds GTP-locked active Rab10 at the plasma membrane, and this interaction depends on the phosphorylation status of the MARCKS effector domain; silencing MARCKS or disrupting its interaction with Rab10 inhibits axonal growth, impairs docking/fusion of Rab10 vesicles with the plasma membrane, and prevents membrane insertion of axonal growth factor receptors. Co-immunoprecipitation, dominant-active Rab10 pull-down, shRNA knockdown, TIRF imaging, in vitro and in vivo neuronal assays Cell research High 24662485
1993 Epitope-tagged Rab10 expressed in CHO and BHK cells concentrates on membranes in the perinuclear region with partial overlap with the Golgi marker β-COP, distinct from Rab8 which localizes to the cell periphery/ruffling areas, establishing that Rab10 and Rab8 occupy distinct cellular compartments despite 66% sequence identity. HA-epitope tagging, immunofluorescence in stably transfected CHO, BHK, and Swiss 3T3 cells Proceedings of the National Academy of Sciences of the United States of America Medium 7688123
2010 Rab10 co-localizes with exocyst proteins at the base of primary cilia in renal epithelial cells in culture and in vivo, and physically interacts with the exocyst complex detected by anti-Sec8 co-immunoprecipitation, suggesting Rab10 mediates membrane transport to the primary cilium through exocyst interactions. Immunofluorescence colocalization, co-immunoprecipitation with anti-Sec8 antibody, in vivo renal tissue analysis American journal of physiology. Renal physiology Medium 20576682
2016 LRRK2 directly phosphorylates Rab10 at a conserved threonine residue (Thr73) in the effector-binding switch-II motif; phosphorylation is ablated in kinase-inactive LRRK2[D2017A] knockin cells/tissues, establishing LRRK2 as the major Rab10 kinase; pathogenic mutations G2019S and R1441G increase Rab10 phosphorylation; Ser910/Ser935 phosphorylation of LRRK2 and 14-3-3 binding facilitate Rab10 phosphorylation in vivo. Phos-tag electrophoresis, knockin mouse models (kinase-dead and phosphomutant), LRRK2 kinase inhibitor treatment The Biochemical journal High 27474410
2019 LRRK2-phosphorylated Rab10 (pT73) accumulates on depolarized mitochondria in a PINK1- and PRKN-dependent manner; Rab10 binds the autophagy receptor OPTN and promotes its accumulation on depolarized mitochondria to facilitate mitophagy. Pathogenic LRRK2 mutations (G2019S, R1441C) enhance Rab10 T73 phosphorylation, impairing Rab10-OPTN interaction and depolarization-induced mitophagy; phosphomimetic Rab10 T73E fails to rescue mitophagy in LRRK2-mutant cells. Co-immunoprecipitation, immunofluorescence, CCCP-induced depolarization, LRRK2 knockdown/inhibitor rescue, patient-derived cells Autophagy High 30945962
2019 LRRK2-phosphorylated Rab10 is recruited to centrosome-localized RILPL1, causing centrosomal cohesion deficits and ciliogenesis defects; both RAB8 and RAB10 contribute to these defects, which are reverted by LRRK2 kinase inhibition and are observed in patient-derived peripheral cells and primary astrocytes from mutant LRRK2 mice. Immunofluorescence, phospho-specific antibodies, LRRK2 kinase inhibition, patient-derived cells, mutant LRRK2 mice Human molecular genetics High 31428781
2021 LRRK2 kinase activity decreases the overall probability of ciliation without changing cilia formation rates; pathogenic LRRK2 blocks release of CP110 from the mother centriole by preventing TTBK2 recruitment, requiring both Rab10 and RILPL1. Deciliation probability relies on a distinct LRRK2 pathway independent of Rab10 and RILPL1. Live-cell fluorescence microscopy, R1441C LRRK2 MEFs, Rab10 and RILPL1 knockout cells, serum starvation/readdition ciliation assays Proceedings of the National Academy of Sciences of the United States of America High 33653948
2021 LRRK2-phosphorylated Rab10 sequesters Myosin Va with RILPL2 at the peri-centriolar region; the globular tail domain of Myosin Va contains a high-affinity binding site for LRRK2-phosphorylated Rab10; pathogenic LRRK2 causes phosphoRab10-dependent RILPL2 and MyoVa relocalization to the peri-centriolar region, as confirmed by FLIP microscopy. RILPL2 overexpression blocks ciliogenesis independent of TTBK2 recruitment. Co-immunoprecipitation, FLIP (fluorescence loss in photobleaching), phospho-specific pulldown, dominant-active/pathogenic LRRK2 mutants Life science alliance High 33727250
2020 Rab10 specifically regulates macropinocytosis in macrophages, dendritic cells, and microglia without affecting phagocytosis or clathrin-mediated endocytosis; LRRK2 phosphorylates cytoplasmic PI(3,4,5)P3-positive GTP-Rab10 before EEA1/Rab5 recruitment to early macropinosomes; LRRK2 phosphorylation of Rab10 blocks EHBP1L1-mediated recycling tubules, stalling macropinosome cargo recycling and promoting PI3K-Akt immunological responses. siRNA knockdown in primary mouse and human macrophages/microglia, LRRK2 kinase inhibition, live-cell imaging, EHBP1L1 competitive overexpression The EMBO journal High 32853409
2016 Rab10 activity is required for lipophagy (autophagic engulfment of lipid droplets) in hepatocytes; Rab10 is recruited to nascent autophagic membranes at the lipid droplet surface during autophagy. Rab10 activation stimulates its association with EHBP1 and the membrane-deforming ATPase EHD2, forming a complex essential for engulfment of lipid droplets by growing autophagosomes; Rab10 knockdown or GTPase-defective variant causes lipid droplet accumulation and blocks LC3 recruitment. siRNA knockdown, GTPase-defective mutant expression, co-immunoprecipitation, immunofluorescence in hepatocytes Science advances High 28028537
2010 RAB-10 and the calponin-homology domain protein EHBP-1 function together in endocytic recycling in C. elegans intestinal cells and interneurons; yeast two-hybrid identified EHBP-1 as a RAB-10 binding partner; EHBP-1-GFP colocalizes with RFP-RAB-10 on endosomal structures, and ehbp-1 loss-of-function mutants share specific endosome morphology and cargo localization defects with rab-10 mutants. Yeast two-hybrid, colocalization, genetic loss-of-function analysis in C. elegans Molecular biology of the cell High 20573983
2014 In C. elegans, RAB-10 cooperates with the exocyst subunit SEC-10 and microtubules to form endosomal tubular networks required for basolateral recycling of clathrin-independent cargoes (hTAC, GLUT1, DAF-4); SEC-10 acts at an intermediate step between early endosomes and recycling endosomes; epistasis analysis places SEC-10 downstream of early endosomes and upstream of recycling endosomes, in a pathway dependent on RAB-10. RNAi knockdown, fluorescent cargo tracking, epistasis analysis, electron microscopy in C. elegans intestine Proceedings of the National Academy of Sciences of the United States of America High 25301900
2009 Rab10 associates transiently with phagosomal membranes early (before Rab5 acquisition) and regulates phagosome maturation; Rab10 knockdown or dominant-negative expression delays phagosome maturation; constitutively active Rab10 partially rescues maturation of live Mycobacterium-containing phagosomes and enables EEA1 acquisition on normally arrested phagosomes. siRNA knockdown, dominant-negative and constitutively active Rab10 mutants, confocal microscopy, live-Mycobacterium infection assays Traffic High 20028485
2013 In Drosophila follicle cells, Rab10 is targeted by the DENN-domain protein Crag to structures in the basal cytoplasm, where it restricts secretion of basement membrane proteins to the basal cell surface; Rab10 and Tango1-positive ER exit sites are planar polarized at the basal epithelial surface, coupling BM protein synthesis and polarized secretion to organ morphogenesis. Genetic loss-of-function, live imaging, immunofluorescence, epistasis with Crag and Tango1 in Drosophila follicle cells Developmental cell High 23369713
2019 Rab10 localizes to tubular endosomes and its knockout completely abolishes tubular endosomal structures in HeLaM cells; Rab10 interacts with kinesin motors KIF13A and KIF13B (identified by in silico screening and validated); both the Rab10-binding homology domain and motor domain of KIF13A are required for Rab10-positive tubular endosome formation. CRISPR knockout, in silico screening followed by experimental validation, domain analysis with KIF13A truncations Journal of cell science High 30700496
2021 Salmonella effector SopD contains a C-terminal GTPase-activating protein (GAP) domain that directly binds and inhibits Rab10 GTPase; during infection, Rab10 and its effectors MICAL-L1 and EHBP1 are recruited to invasion sites, and SopD-mediated inhibition of Rab10 promotes removal of Rab10 and recruitment of Dynamin-2 to drive plasma membrane scission and Salmonella-containing vacuole formation. Biochemical GAP assay, co-immunoprecipitation, infection assays, Dynamin-2 recruitment imaging Nature communications High 34349110
2014 Rab10 GTPase mediates endocytosis of hyaluronan synthase HAS3 from the plasma membrane to early endosomes; Rab10 colocalized with HAS3 in intracellular vesicles and was co-immunoprecipitated with HAS3 from isolated endosomes; Rab10 silencing increases plasma membrane HAS3 and HA synthesis, whereas overexpression suppresses HA synthesis; reduced endocytosis of HAS3 enlarges the HA coat and impairs cell adhesion to type I collagen. siRNA silencing, overexpression, co-immunoprecipitation from endosomal fractions, HA synthesis assays, cell adhesion assay The Journal of biological chemistry Medium 24509846
2022 RAB10 promotes endosomal recycling of the LDL receptor (LDLR) from RAB11-positive endosomes to the plasma membrane in hepatocytes, and also promotes recycling of the transferrin receptor from a distinct RAB4-positive compartment. Genome-wide CRISPR screen followed by targeted validation, receptor recycling assays, compartment marker colocalization Journal of lipid research Medium 35753407
2023 Rab10 controls sorting of internalized TrkB receptors into signaling endosomes for retrograde axonal transport; Rab10 defines a membrane compartment that is rapidly mobilized toward the axon terminal upon BDNF stimulation, enabling fine-tuning of retrograde signaling from axon to soma. Primary mouse neuron cultures, live-cell imaging, BDNF stimulation assays, dominant-active/negative Rab10 mutants, retrograde transport tracking eLife High 36897066
2022 Lysosomal positioning regulates Rab10 phosphorylation by LRRK2: pRab10 is restricted to perinuclear lysosomes, and anterograde transport of lysosomes to the cell periphery (via ARL8B/SKIP overexpression or JIP4 knockdown) blocks Rab10 recruitment and phosphorylation. Conversely, clustering lysosomes in the perinuclear area (via RILP overexpression) increases LRRK2-dependent Rab10 phosphorylation. Phosphatase PPM1H knockdown significantly increases pRab10 and lysosomal tubulation. LRRK2 lysosome-targeting constructs, ARL8B/SKIP overexpression, RILP overexpression, JIP4 and PPM1H siRNA knockdown, phospho-specific imaging Proceedings of the National Academy of Sciences of the United States of America High 36256825
2022 RILPL1 localizes to the subdistal appendage of the mother centriole; LRRK2-phosphorylated Rab10 is recruited to RILPL1 at this location to cause centrosomal cohesion deficits and CDK5RAP2 displacement; centrosomal alterations require GTP-bound and phosphorylated Rab proteins and impair cell polarization (scratch wound assay), reverted by LRRK2 kinase inhibition. Transfected cell lines, patient-derived iPS cells, immunofluorescence, dominant/constitutive mutants, scratch wound assay, LRRK2 inhibitor treatment Biology open / iScience High 35721463 35776681
2024 VPS13C interacts with phospho-Rab10 (pRab10) as a phospho-dependent interactor on lysosomes in human iPSC-derived dopaminergic neurons; loss of VPS13C disrupts lysosomal morphology, dynamics, motility, distribution, hydrolytic activity, and acidification, and decreases the phospho-Rab10-mediated lysosomal stress response. Live-cell microscopy in iPSC-derived dopaminergic neurons, VPS13C knockout, phospho-Rab10 pulldown/interaction assays The Journal of cell biology High 38358348
2024 Rab10 and Caveolin-1 (CAV1) mark intraluminal vesicles in migrasomes; transport of Rab10-CAV1 vesicles to migrasomes requires the motor protein Myosin Va and adaptor protein RILPL2; LRRK2-mediated phosphorylation of Rab10 regulates this transport. CSF-1 is transported to migrasomes via this mechanism to foster monocyte-macrophage differentiation during wound healing. Live-cell imaging, Co-IP, dominant-negative/phosphomimetic Rab10 mutants, LRRK2 kinase inhibition, wound-healing model Proceedings of the National Academy of Sciences of the United States of America Medium 39008679
2015 RAB-10 in C. elegans controls dendritic branch distribution in the PVD sensory neuron by balancing the activities of molecular motors kinesin-1/UNC-116 and dynein; the exocyst complex cooperates with RAB-10 as a critical regulator of dendrite morphogenesis. Genetic loss-of-function, motor mutant epistasis, fluorescent reporter imaging in C. elegans PLoS genetics Medium 26633194
2017 RAB-10 promotes autophagic flux in C. elegans by regulating autophagosome formation and maturation, and controls the size of ATG-9-positive structures; GTPase cycling of RAB-10 is required to control ATG-9 foci size. RNAi, GFP::LGG-1 and GFP::ATG-9 reporters, chloroquine flux assay, colocalization with lysosome markers in C. elegans Autophagy Medium 28872980
2011 In human endothelial cells, Rab10 is enriched at the Golgi and is required for biogenesis of Weibel-Palade bodies (WPB); siRNA-mediated Rab10 suppression significantly reduces rapidly released von Willebrand factor upon secretagogue stimulation, placing Rab10 in WPB biogenesis at the Golgi. RNAi in HUVECs, VWF secretion assay, immunofluorescence colocalization with Golgi marker; initial hit identified by genome-wide RNAi screen in C. elegans Journal of thrombosis and haemostasis Medium 21070595
2016 Rab10-mediated secretion pathway promotes pericellular basement membrane protein accumulation and fibril formation in Drosophila egg chamber; live imaging and genetic manipulation show BM fibrils are assembled in pericellular spaces and oriented by directed epithelial migration; manipulating the Rab10-based secretion pathway alters BM fibrillar structure and egg chamber morphogenesis. Live imaging, genetic loss-of-function, manipulation of secretion pathway in Drosophila Developmental cell Medium 27404358
2015 RAB-10 and amphiphysin AMPH-1 bind to RAB-5 GAP TBC-2 and recruit it to endosomes; in the absence of RAB-10 or AMPH-1 binding, RAB-5 membrane association is abnormally high, trapping recycling cargo in early endosomes. This identifies RAB-10/AMPH-1-mediated TBC-2 recruitment as a mechanism for RAB-5 downregulation required for cargo exit from early endosomes. Genetic loss-of-function, epistasis, colocalization, cargo trafficking assays in C. elegans PLoS genetics Medium 26393361
2020 LRRK2 phosphorylation of Rab10 is potently stimulated by lysosomotropic drugs (lysosomal stressors) through enhanced molecular proximity of LRRK2 and Rab GTPases on the cytosolic surface of LRRK2-coated enlarged lysosomes, downstream of Rab29-mediated LRRK2 activation; this is not due to increased LRRK2 enzymatic activity per se. Pharmacological lysosomal stress, proximity ligation, Rab29 epistasis, autophosphorylation assays in cell lines Neurobiology of disease Medium 32919031
2017 RAB10 interacts with MGCRABGAP (a male germ cell-specific RabGAP containing a TBC domain) during spermiogenesis; MGCRABGAP exhibits GTPase-activating activity; MGCRABGAP-RAB10 complexes colocalize specifically in the manchette structure of spermatids, a critical structure for spermatid head formation. Co-immunoprecipitation, nano LC-MS/MS proteomics, GTPase activity assay, immunofluorescence colocalization International journal of molecular sciences Medium 28067790
2019 Activated α2-macroglobulin (α2M*) induces LRP1 recycling to the plasma membrane through a Rab10-dependent exocytic pathway regulated by PI3K/Akt in retinal Müller glial cells; Rab10 knockdown reduces LRP1 accumulation at the plasma membrane and impairs α2M*-induced cell migration. siRNA knockdown, receptor trafficking assays, PI3K/Akt inhibition, live imaging in MIO-M1 cells Scientific reports Medium 31519919

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2007 Rab10, a target of the AS160 Rab GAP, is required for insulin-stimulated translocation of GLUT4 to the adipocyte plasma membrane. Cell metabolism 296 17403373
2012 Rab10 GTPase regulates ER dynamics and morphology. Nature cell biology 191 23263280
2006 RAB-10 is required for endocytic recycling in the Caenorhabditis elegans intestine. Molecular biology of the cell 182 16394106
2019 LRRK2 mutations impair depolarization-induced mitophagy through inhibition of mitochondrial accumulation of RAB10. Autophagy 157 30945962
2016 A novel Rab10-EHBP1-EHD2 complex essential for the autophagic engulfment of lipid droplets. Science advances 152 28028537
1993 Expression and localization of two low molecular weight GTP-binding proteins, Rab8 and Rab10, by epitope tag. Proceedings of the National Academy of Sciences of the United States of America 142 7688123
2016 Phos-tag analysis of Rab10 phosphorylation by LRRK2: a powerful assay for assessing kinase function and inhibitors. The Biochemical journal 139 27474410
2012 Rab10 and myosin-Va mediate insulin-stimulated GLUT4 storage vesicle translocation in adipocytes. The Journal of cell biology 139 22908308
2006 Rab10 regulates membrane transport through early endosomes of polarized Madin-Darby canine kidney cells. Molecular biology of the cell 136 16641372
2010 Ras-related protein Rab10 facilitates TLR4 signaling by promoting replenishment of TLR4 onto the plasma membrane. Proceedings of the National Academy of Sciences of the United States of America 135 20643919
2013 A Rab10-dependent mechanism for polarized basement membrane secretion during organ morphogenesis. Developmental cell 127 23369713
2018 Interrogating Parkinson's disease LRRK2 kinase pathway activity by assessing Rab10 phosphorylation in human neutrophils. The Biochemical journal 117 29127255
2010 EHBP-1 functions with RAB-10 during endocytic recycling in Caenorhabditis elegans. Molecular biology of the cell 102 20573983
2006 Rab10 is involved in basolateral transport in polarized Madin-Darby canine kidney cells. Traffic (Copenhagen, Denmark) 102 17132146
2011 Lgl1 activation of rab10 promotes axonal membrane trafficking underlying neuronal polarization. Developmental cell 100 21856246
2008 Alternative splicing in class V myosins determines association with Rab10. The Journal of biological chemistry 95 19008234
2016 Rab10-Mediated Secretion Synergizes with Tissue Movement to Build a Polarized Basement Membrane Architecture for Organ Morphogenesis. Developmental cell 94 27404358
2008 Rab10 in insulin-stimulated GLUT4 translocation. The Biochemical journal 92 18076383
2019 Rab10 regulates tubular endosome formation through KIF13A and KIF13B motors. Journal of cell science 88 30700496
2018 LRRK2-mediated Rab10 phosphorylation in immune cells from Parkinson's disease patients. Movement disorders : official journal of the Movement Disorder Society 79 30597610
2017 Selective LRRK2 kinase inhibition reduces phosphorylation of endogenous Rab10 and Rab12 in human peripheral mononuclear blood cells. Scientific reports 79 28860483
2020 LRRK2 and Rab10 coordinate macropinocytosis to mediate immunological responses in phagocytes. The EMBO journal 76 32853409
2010 Rab10 associates with primary cilia and the exocyst complex in renal epithelial cells. American journal of physiology. Renal physiology 76 20576682
2007 RAB-10 regulates glutamate receptor recycling in a cholesterol-dependent endocytosis pathway. Molecular biology of the cell 76 17761527
2019 RAB8, RAB10 and RILPL1 contribute to both LRRK2 kinase-mediated centrosomal cohesion and ciliogenesis deficits. Human molecular genetics 73 31428781
2013 Myosin Vb controls biogenesis of post-Golgi Rab10 carriers during axon development. Nature communications 70 23770993
2017 [6]-Gingerol, from Zingiber officinale, potentiates GLP-1 mediated glucose-stimulated insulin secretion pathway in pancreatic β-cells and increases RAB8/RAB10-regulated membrane presentation of GLUT4 transporters in skeletal muscle to improve hyperglycemia in Leprdb/db type 2 diabetic mice. BMC complementary and alternative medicine 68 28793909
2015 RAB-10 Regulates Dendritic Branching by Balancing Dendritic Transport. PLoS genetics 68 26633194
2021 Pathogenic LRRK2 regulates ciliation probability upstream of tau tubulin kinase 2 via Rab10 and RILPL1 proteins. Proceedings of the National Academy of Sciences of the United States of America 66 33653948
2017 Linkage, whole genome sequence, and biological data implicate variants in RAB10 in Alzheimer's disease resilience. Genome medicine 66 29183403
2020 LRRK2 Is Recruited to Phagosomes and Co-recruits RAB8 and RAB10 in Human Pluripotent Stem Cell-Derived Macrophages. Stem cell reports 65 32359446
2011 Insulin-stimulated GLUT4 protein translocation in adipocytes requires the Rab10 guanine nucleotide exchange factor Dennd4C. The Journal of biological chemistry 65 21454697
2014 MARCKS regulates membrane targeting of Rab10 vesicles to promote axon development. Cell research 61 24662485
2009 Rab10 regulates phagosome maturation and its overexpression rescues Mycobacterium-containing phagosomes maturation. Traffic (Copenhagen, Denmark) 61 20028485
2014 JIP1 mediates anterograde transport of Rab10 cargos during neuronal polarization. The Journal of neuroscience : the official journal of the Society for Neuroscience 57 24478353
2021 R1441G but not G2019S mutation enhances LRRK2 mediated Rab10 phosphorylation in human peripheral blood neutrophils. Acta neuropathologica 53 34125248
2020 Roles of lysosomotropic agents on LRRK2 activation and Rab10 phosphorylation. Neurobiology of disease 52 32919031
2016 SEC16A is a RAB10 effector required for insulin-stimulated GLUT4 trafficking in adipocytes. The Journal of cell biology 48 27354378
2016 MiR-329 suppresses osteosarcoma development by downregulating Rab10. FEBS letters 46 27487475
2022 Lysosomal positioning regulates Rab10 phosphorylation at LRRK2+ lysosomes. Proceedings of the National Academy of Sciences of the United States of America 44 36256825
2020 Accurate MS-based Rab10 Phosphorylation Stoichiometry Determination as Readout for LRRK2 Activity in Parkinson's Disease. Molecular & cellular proteomics : MCP 44 32601174
2020 Divergent Effects of G2019S and R1441C LRRK2 Mutations on LRRK2 and Rab10 Phosphorylations in Mouse Tissues. Cells 44 33105882
2021 LRRK2-phosphorylated Rab10 sequesters Myosin Va with RILPL2 during ciliogenesis blockade. Life science alliance 41 33727250
2016 Rab3a and Rab10 are regulators of lysosome exocytosis and plasma membrane repair. Small GTPases 41 27687479
2021 Understanding LRRK2 kinase activity in preclinical models and human subjects through quantitative analysis of LRRK2 and pT73 Rab10. Scientific reports 40 34145320
2023 The role of microglial LRRK2 kinase in manganese-induced inflammatory neurotoxicity via NLRP3 inflammasome and RAB10-mediated autophagy dysfunction. The Journal of biological chemistry 37 37269951
2014 A Rab10:RalA G protein cascade regulates insulin-stimulated glucose uptake in adipocytes. Molecular biology of the cell 37 25103239
2021 LncRNA EBLN3P promotes the progression of osteosarcoma through modifying the miR-224-5p/Rab10 signaling axis. Scientific reports 36 33479458
2023 Exosomal miR-10527-5p Inhibits Migration, Invasion, Lymphangiogenesis and Lymphatic Metastasis by Affecting Wnt/β-Catenin Signaling via Rab10 in Esophageal Squamous Cell Carcinoma. International journal of nanomedicine 35 36636641
2020 microRNA-519d Induces Autophagy and Apoptosis of Human Hepatocellular Carcinoma Cells Through Activation of the AMPK Signaling Pathway via Rab10. Cancer management and research 34 32346312
2018 Rab10 Phosphorylation is a Prominent Pathological Feature in Alzheimer's Disease. Journal of Alzheimer's disease : JAD 34 29562525
2015 Anaplasma phagocytophilum Rab10-dependent parasitism of the trans-Golgi network is critical for completion of the infection cycle. Cellular microbiology 34 26289115
2015 A potential link between insulin signaling and GLUT4 translocation: Association of Rab10-GTP with the exocyst subunit Exoc6/6b. Biochemical and biophysical research communications 32 26299925
2015 Basolateral Endocytic Recycling Requires RAB-10 and AMPH-1 Mediated Recruitment of RAB-5 GAP TBC-2 to Endosomes. PLoS genetics 32 26393361
2014 SEC-10 and RAB-10 coordinate basolateral recycling of clathrin-independent cargo through endosomal tubules in Caenorhabditis elegans. Proceedings of the National Academy of Sciences of the United States of America 32 25301900
2020 Down-regulation of circ-PTN suppresses cell proliferation, invasion and glycolysis in glioma by regulating miR-432-5p/RAB10 axis. Neuroscience letters 29 32629066
2018 miR‑378a‑3p exerts tumor suppressive function on the tumorigenesis of esophageal squamous cell carcinoma by targeting Rab10. International journal of molecular medicine 29 29693138
2022 Circular RNA hsa_circ_0001658 regulates apoptosis and autophagy in gastric cancer through microRNA-182/Ras-related protein Rab-10 signaling axis. Bioengineered 28 35030981
2020 Distinct Roles for RAB10 and RAB29 in Pathogenic LRRK2-Mediated Endolysosomal Trafficking Alterations. Cells 27 32709066
2019 PSMB8-AS1 activated by ELK1 promotes cell proliferation in glioma via regulating miR-574-5p/RAB10. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 27 31812014
2014 Rab10-mediated endocytosis of the hyaluronan synthase HAS3 regulates hyaluronan synthesis and cell adhesion to collagen. The Journal of biological chemistry 26 24509846
2024 Rab10-CAV1 mediated intraluminal vesicle transport to migrasomes. Proceedings of the National Academy of Sciences of the United States of America 25 39008679
2022 Elevated Urinary Rab10 Phosphorylation in Idiopathic Parkinson Disease. Movement disorders : official journal of the Movement Disorder Society 25 35521944
2020 Insulin-promoted mobilization of GLUT4 from a perinuclear storage site requires RAB10. Molecular biology of the cell 25 33175605
2017 The recycling endosome protein RAB-10 promotes autophagic flux and localization of the transmembrane protein ATG-9. Autophagy 25 28872980
2020 Knockdown of circular RNA UBAP2 inhibits the malignant behaviours of esophageal squamous cell carcinoma by microRNA-422a/Rab10 axis. Clinical and experimental pharmacology & physiology 24 32012318
2017 RAB10 Interacts with the Male Germ Cell-Specific GTPase-Activating Protein during Mammalian Spermiogenesis. International journal of molecular sciences 24 28067790
2021 FAM49B promotes breast cancer proliferation, metastasis, and chemoresistance by stabilizing ELAVL1 protein and regulating downstream Rab10/TLR4 pathway. Cancer cell international 23 34645466
2015 Glut4 Is Sorted from a Rab10 GTPase-independent Constitutive Recycling Pathway into a Highly Insulin-responsive Rab10 GTPase-dependent Sequestration Pathway after Adipocyte Differentiation. The Journal of biological chemistry 23 26527681
2024 VPS13C regulates phospho-Rab10-mediated lysosomal function in human dopaminergic neurons. The Journal of cell biology 22 38358348
2020 LncRNA TUG1 Regulates Cell Viability and Death by Regulating miR-193a-5p/Rab10 Axis in Acute Myeloid Leukemia. OncoTargets and therapy 22 32103996
2020 Down-Regulation of miR-378d Increased Rab10 Expression to Help Clearance of Mycobacterium tuberculosis in Macrophages. Frontiers in cellular and infection microbiology 22 32257967
2021 Abrogation of LRRK2 dependent Rab10 phosphorylation with TLR4 activation and alterations in evoked cytokine release in immune cells. Neurochemistry international 21 34004238
2021 Salmonella effector SopD promotes plasma membrane scission by inhibiting Rab10. Nature communications 21 34349110
2023 Age-associated decline in RAB-10 efficacy impairs intestinal barrier integrity. Nature aging 19 37640905
2020 LINC00441 promotes cervical cancer progression by modulating miR-450b-5p/RAB10 axis. Cancer cell international 19 32774162
2013 Insulin triggers surface-directed trafficking of sequestered GLUT4 storage vesicles marked by Rab10. Small GTPases 19 24030635
2022 Pathogenic LRRK2 regulates centrosome cohesion via Rab10/RILPL1-mediated CDK5RAP2 displacement. iScience 18 35721463
2022 The small GTPase RAB10 regulates endosomal recycling of the LDL receptor and transferrin receptor in hepatocytes. Journal of lipid research 18 35753407
2022 The LRRK2 signaling network converges on a centriolar phospho-Rab10/RILPL1 complex to cause deficits in centrosome cohesion and cell polarization. Biology open 18 35776681
2021 Long noncoding RNA CYTOR triggers gastric cancer progression by targeting miR-103/RAB10. Acta biochimica et biophysica Sinica 17 34110382
2013 Rab10 delivers GLUT4 storage vesicles to the plasma membrane. Communicative & integrative biology 17 23713133
2011 A role for Rab10 in von Willebrand factor release discovered by an AP-1 interactor screen in C. elegans. Journal of thrombosis and haemostasis : JTH 15 21070595
2023 LRRK2 phosphorylation status and kinase activity regulate (macro)autophagy in a Rab8a/Rab10-dependent manner. Cell death & disease 14 37454104
2021 Multiple Pathways of LRRK2-G2019S/Rab10 Interaction in Dopaminergic Neurons. Journal of Parkinson's disease 14 34250948
2018 The pervasive effects of recombinant Fasciola gigantica Ras-related protein Rab10 on the functions of goat peripheral blood mononuclear cells. Parasites & vectors 14 30400957
2023 Rab10 regulates the sorting of internalised TrkB for retrograde axonal transport. eLife 13 36897066
2022 Circ_KCNQ5 participates in the progression of childhood acute myeloid leukemia by enhancing the expression of RAB10 via binding to miR-622. Hematology (Amsterdam, Netherlands) 13 35413218
2015 Role for Rab10 in Methamphetamine-Induced Behavior. PloS one 13 26291453
2024 Lysosomal stress drives the release of pathogenic α-synuclein from macrophage lineage cells via the LRRK2-Rab10 pathway. iScience 12 38313055
2022 LncRNA136131 suppresses apoptosis of renal tubular epithelial cells in acute kidney injury by targeting the miR-378a-3p/Rab10 axis. Aging 12 35482482
2019 Long Non-Coding RNA LINC00152 Regulates Cell Proliferation, Migration And Invasion In Esophageal Squamous Cell Carcinoma Via miR-107/Rab10 Axis. OncoTargets and therapy 12 31802892
2019 Activated α2-Macroglobulin Regulates LRP1 Levels at the Plasma Membrane through the Activation of a Rab10-dependent Exocytic Pathway in Retinal Müller Glial Cells. Scientific reports 11 31519919
1998 Analysis of rab10 localization in sea urchin embryonic cells by three-dimensional reconstruction. Experimental cell research 11 9716447
2021 Case Report: RAB10-ALK: A Novel ALK Fusion in a Patient With Gastric Cancer. Frontiers in oncology 10 33692962
2021 Rab10-Positive Tubular Structures Represent a Novel Endocytic Pathway That Diverges From Canonical Macropinocytosis in RAW264 Macrophages. Frontiers in immunology 10 34135890
2020 Human Peripheral Blood Neutrophil Isolation for Interrogating the Parkinson's Associated LRRK2 Kinase Pathway by Assessing Rab10 Phosphorylation. Journal of visualized experiments : JoVE 10 32250352
2025 Layered Double Hydroxide LDH-Loaded miR-141-3p Targets RAB10 Suppressing Cellular Autophagy to Reverse Paclitaxel Resistance in Breast Cancer. ACS omega 9 39989842
2024 The LRRK2 kinase substrates RAB8a and RAB10 contribute complementary but distinct disease-relevant phenotypes in human neurons. Stem cell reports 9 38307024
2021 LINC00152 acts as a potential marker in gliomas and promotes tumor proliferation and invasion through the LINC00152/miR-107/RAB10 axis. Journal of neuro-oncology 9 34478013