Affinage

MYO5A

Unconventional myosin-Va · UniProt Q9Y4I1

Round 2 corrected
Length
1855 aa
Mass
215.4 kDa
Annotated
2026-04-29
83 papers in source corpus 19 papers cited in narrative 18 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

MYO5A encodes a processive, actin-based molecular motor that takes ~36-nm steps along actin filaments and transports diverse membrane-bound organelles to the cell periphery and to specialized subcellular domains (PMID:10448864). In melanocytes, MYO5A is recruited to melanosomes via a tripartite Rab27A–melanophilin–myosin Va complex that requires the tissue-specific F-exon isoform, and loss-of-function mutations cause Griscelli syndrome type 1, characterized by pigmentary dilution with or without neurological impairment (PMID:11856727, PMID:9207796, PMID:12897212). In neurons, MYO5A drives Rab11-dependent AMPA receptor insertion into dendritic spines during long-term potentiation, distributes smooth endoplasmic reticulum vesicles in Purkinje cell dendrites, interacts with the endosomal effector ANKFY1, and maintains mitochondrial morphology (PMID:18311135, PMID:10749990, PMID:40022605). MYO5A additionally sequesters the BH3-only pro-apoptotic protein Bmf via dynein light chain 2, linking the actin-based motor to anoikis regulation (PMID:11546872).

Mechanistic history

Synthesis pass · year-by-year structured walk · 11 steps
  1. 1994 Medium

    Cloning of human MYO5A (MYH12) and mapping to 15q21 established the molecular identity of the human orthologue of the mouse dilute gene, enabling subsequent functional and genetic studies.

    Evidence PCR cloning from human brain cDNA library, somatic cell hybrid mapping, and sequence comparison with mouse dilute

    PMID:7835087 PMID:8188282

    Open questions at the time
    • No functional characterization performed
    • Motor activity not yet demonstrated for the human protein
  2. 1997 High

    Identification of MYO5A mutations in Griscelli syndrome patients established that this motor is essential for melanosome transport in humans and linked it to pigmentary dilution and neurological disease.

    Evidence Genetic linkage mapping to 15q21 and mutation analysis in GS patients, consistent with the mouse dilute phenotype

    PMID:9207796

    Open questions at the time
    • Cargo-recognition mechanism unknown at this point
    • Neurological versus pigmentary pathways not yet dissected
  3. 1999 High

    Single-molecule measurements demonstrated that myosin Va is an intrinsically processive motor taking ~36-nm steps, resolving the fundamental question of whether a single motor molecule can sustain organelle transport along actin.

    Evidence Optical trap and bead motility assays with purified myosin Va on actin filaments in vitro

    PMID:10448864

    Open questions at the time
    • Regulation of processivity in vivo not addressed
    • Cargo-induced changes in motility unknown
  4. 2000 High

    Analysis of the flailer mouse and PSD-95 complex studies placed MYO5A in neuronal organelle transport: the flailer dominant-negative globular tail disrupted smooth ER vesicle localization in Purkinje cell dendritic spines, and MYO5A co-immunoprecipitated with a PSD-95–GKAP–DLC complex from brain.

    Evidence Molecular characterization of the Gnb5-MYO5A fusion in flailer mice with immunolocalization of SER vesicles; co-IP and immunogold EM from rat brain

    PMID:10749990 PMID:10844022

    Open questions at the time
    • Direct motor activity requirement for SER positioning not tested
    • PSD-95 complex interaction lacks reciprocal MYO5A-specific validation
  5. 2001 High

    Discovery that the BH3-only protein Bmf is sequestered on myosin V motors via DLC2 revealed a non-transport function: linking actin cytoskeleton integrity to apoptosis signaling during anoikis.

    Evidence Co-immunoprecipitation, yeast two-hybrid, BH3 mutagenesis, and anoikis functional assays

    PMID:11546872

    Open questions at the time
    • Stoichiometry of Bmf–DLC2–MYO5A complex not defined
    • Whether MYO5A actively transports Bmf or merely anchors it is unresolved
  6. 2002 High

    Biochemical reconstitution of the Rab27A–melanophilin–myosin Va tripartite complex solved the cargo-recognition problem: melanophilin bridges GTP-Rab27A on melanosome membranes to the myosin Va globular tail, and mRNP association linked MYO5A to somatodendritic mRNA transport.

    Evidence Deletion/mutagenesis mapping, reciprocal co-IP from melanoma cells and neurons, yeast two-hybrid, dominant-negative perturbation in melanocytes; RNase-sensitive co-IP with Puralpha/mStaufen/FMRP

    PMID:11856727 PMID:11980908 PMID:12147688

    Open questions at the time
    • Structural basis of melanophilin–myosin Va interaction not resolved
    • MYO5A's specific mechanistic contribution to mRNA transport not functionally dissected
  7. 2003 High

    Identification of F-exon deletion patients with isolated hypopigmentation but no neurological disease dissected tissue-specific isoform function, establishing that the F-exon-containing MYO5A isoform is selectively required in melanocytes.

    Evidence Genetic analysis of Griscelli syndrome patients with isolated F-exon deletions, correlated with tissue-restricted expression data

    PMID:12897212

    Open questions at the time
    • Which neuronal isoform(s) compensate for F-exon loss in the brain is unknown
    • Full alternative splicing landscape of MYO5A not mapped
  8. 2004 High

    Genetic epistasis with the dilute suppressor (dsu) demonstrated that MYO5A is required for peripheral melanosome accumulation but is dispensable for melanosome transfer from melanocytes to keratinocytes, separating intra- from inter-cellular pigment pathways.

    Evidence dsu suppressor screen in MYO5A-deficient mice with histological assessment

    PMID:15550542

    Open questions at the time
    • Molecular identity of the dsu-dependent compensatory pathway was not defined in this study
  9. 2008 High

    Demonstration that MYO5A drives CaMKII-triggered AMPA receptor insertion into dendritic spines during LTP—enhanced by GTP-Rab11—established a specific neuronal transport function, explaining cerebellar and hippocampal phenotypes in MYO5A deficiency.

    Evidence Co-IP of myosin Va with GluR1, dominant-negative tail expression, live receptor imaging, and electrophysiological LTP recordings in rat hippocampal slices

    PMID:18311135

    Open questions at the time
    • Whether MYO5A also contributes to AMPAR endocytic recycling is untested
    • Structural basis for Rab11-enhanced MYO5A–AMPAR interaction unknown
  10. 2017 Medium

    Characterization of Myo5a-null rat brains revealed hyperphosphorylation and mitochondrial accumulation of alpha-synuclein, impaired respiratory complex activity, and DOPAL accumulation, linking MYO5A-dependent transport to neurodegenerative pathology.

    Evidence Myo5a-knockout rat model with immunohistochemistry, respiratory complex assays, and DOPAL measurements in dopaminergic neurons

    PMID:29217155

    Open questions at the time
    • Causal chain from transport defect to alpha-synuclein aggregation not mechanistically dissected
    • Whether phenotype is cell-autonomous in dopaminergic neurons is untested
  11. 2025 Medium

    Proteomics and co-IP from Myo5a-null cerebellum identified ANKFY1 (a Rab5A effector) as a novel MYO5A interactor and revealed elongated mitochondria in MYO5A-deficient neurons, expanding MYO5A's neuronal roles to early endosome transport and mitochondrial homeostasis.

    Evidence Mass spectrometry of cerebellar extracts from splice-variant Myo5a-null mice, co-immunoprecipitation, and primary neuron imaging

    PMID:40022605

    Open questions at the time
    • ANKFY1 interaction awaits reciprocal validation and reconstitution
    • Mechanism linking MYO5A loss to mitochondrial elongation is unknown
    • Single study requiring independent replication

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key open questions include the structural basis of auto-inhibition and cargo-induced activation of the full-length human MYO5A, the identity of neuronal cargo adaptors beyond melanophilin and Rab11, and whether MYO5A's role in mitochondrial morphology is direct or secondary to endosomal transport defects.
  • No high-resolution structure of full-length human MYO5A or GTD–cargo complex published
  • Neuronal cargo adaptor(s) analogous to melanophilin not identified
  • Mitochondrial phenotype mechanism unresolved

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0008092 cytoskeletal protein binding 2 GO:0003774 cytoskeletal motor activity 1 GO:0140657 ATP-dependent activity 1
Localization
GO:0031410 cytoplasmic vesicle 4 GO:0005856 cytoskeleton 3 GO:0005829 cytosol 2
Pathway
R-HSA-5653656 Vesicle-mediated transport 5 R-HSA-112316 Neuronal System 4 R-HSA-5357801 Programmed Cell Death 1 R-HSA-9612973 Autophagy 1
Partners
ANKFY1BMFDLG4DYNLL2FMRPMLPHRAB11RAB27A
Complex memberships
Rab27A–melanophilin–myosin Va tripartite complex

Evidence

Reading pass · 18 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1999 Myosin Va (MYO5A) is a processive actin-based motor that moves in large steps approximating the 36-nm pseudo-repeat of the actin filament, demonstrated by single-molecule mechanical measurements, establishing that single motors can support organelle movement along actin tracks. Single-molecule optical trap and bead motility assays (Tier 1 in vitro reconstitution) Nature High 10448864
1997 Griscelli disease (GS1) maps to chromosome 15q21 and is caused by mutations in the myosin-Va gene (MYO5A), establishing that MYO5A is required for proper melanosome transport in melanocytes and its loss causes pigmentary dilution and immunodeficiency. Genetic linkage mapping, mutation analysis in patients, phenotypic analysis Nature genetics High 9207796
2002 Slac2-a/melanophilin is the missing link between Rab27A and myosin Va: its N-terminal SLP homology domain binds GTP-Rab27A/B on melanosomes, while its C-terminal half directly binds the globular tail of myosin Va, forming a tripartite Rab27A–melanophilin–myosin Va complex that mediates melanosome transport to the cell periphery. Deletion analysis, site-directed mutagenesis, co-immunoprecipitation from melanoma cells, yeast two-hybrid The Journal of biological chemistry High 11856727 11980908
2002 Melanophilin links Rab27a and myosin Va function in melanosome transport: melanophilin associates simultaneously with activated (GTP-bound) Rab27a and the C-terminal tail of the melanocyte-specific splice isoform of myosin Va via distinct domains, confirmed by co-immunoprecipitation from melanocytes. Yeast two-hybrid, co-immunoprecipitation, overexpression of dominant-negative domain in melanocytes causing perinuclear melanosome clustering The Journal of biological chemistry High 11980908
2003 Deletion of the MYO5A F-exon (a tissue-restricted exon) produces Griscelli syndrome restricted to hypopigmentation (GS1) without neurological or immunological phenotype, demonstrating that the F-exon-containing isoform is specifically required in melanocytes for melanosome transport. Genetic analysis of GS patients, identification of F-exon deletion, functional correlation with tissue-restricted expression The Journal of clinical investigation High 12897212
2001 Bmf, a BH3-only pro-apoptotic protein, is sequestered to myosin V motors through association with dynein light chain 2 (DLC2) in healthy cells; loss of cell attachment (anoikis) releases Bmf from the myosin V–DLC2 complex, allowing it to bind pro-survival Bcl-2 proteins and trigger apoptosis. Co-immunoprecipitation, yeast two-hybrid, BH3 mutagenesis, anoikis functional assay Science High 11546872
2008 Myosin Va is required for CaMKII-triggered translocation of GluR1 (AMPA receptor) from dendritic shafts into spines during long-term potentiation (LTP) in rat hippocampus; myosin Va associates with AMPARs through its cargo-binding (globular tail) domain, and this interaction is enhanced by active GTP-bound Rab11. Myosin Va is specifically required for LTP but not for basal synaptic transmission. Co-immunoprecipitation, dominant-negative expression, live imaging of receptor translocation, electrophysiology (LTP recording) Nature neuroscience High 18311135
2000 The flailer mouse mutation produces a novel hybrid protein combining the N-terminal 83 amino acids of Gnb5 with the C-terminal 711 amino acids of MyoVA (including the globular tail organelle-binding domain); this flailer protein acts as a dominant negative by competing with wild-type MyoVA, preventing localization of smooth endoplasmic reticulum vesicles to dendritic spines of cerebellar Purkinje cells. Molecular cloning of hybrid gene, biochemical competition assay, immunolocalization of SER vesicles in Purkinje cells, genetic analysis Human molecular genetics High 10749990
2004 MYO5A is required for peripheral accumulation of melanosomes in melanocytes but is non-essential for melanosome transfer to keratinocytes and hair; the dilute suppressor gene (dsu) suppresses coat color dilution in an MYO5A-independent pathway, identifying a distinct mechanism for pigment incorporation into hair. Mouse genetic epistasis (dsu suppressor screen), MYO5A-deficient mouse analysis, histological assessment of melanosome distribution Proceedings of the National Academy of Sciences of the United States of America High 15550542
2002 Myosin Va associates with mRNA/protein (mRNP) complexes containing Puralpha, mStaufen, and FMRP, and co-localizes with rough endoplasmic reticulum equipped with a kinesin motor in neuronal cells, suggesting a role in somatodendritic mRNA transport. Co-immunoprecipitation (RNase-sensitive), subcellular fractionation, immunoelectron microscopy The Journal of biological chemistry Medium 12147688
2000 A complex containing PSD-95, GKAP, dynein light chain (DLC), and myosin Va can be immunoprecipitated from rat brain extracts; DLC colocalizes with PSD-95 and F-actin in dendritic spines, suggesting myosin Va participates in trafficking of the PSD-95 scaffold complex to postsynaptic sites. Co-immunoprecipitation from brain, yeast two-hybrid, immunogold electron microscopy The Journal of neuroscience Medium 10844022
2004 Rab27a recruits melanophilin as an effector, which in turn binds myosin Va, establishing that Rab GTPases function as organelle-specific receptors for class V myosin motors; this Rab-effector-myosin tripartite mechanism is proposed as a general paradigm for organelle transport. Review/synthesis integrating biochemical and genetic data from melanosome, yeast vesicle, and endosome systems Traffic Medium 15117313
2013 The globular tail domain (GTD) of human Myo5a was crystallized and diffracted to 2.5 Å resolution (space group P2₁2₁2₁), providing the first structural dataset for the human MYO5A cargo-binding and auto-inhibitory domain. Protein expression, purification, crystallization, X-ray diffraction data collection Acta crystallographica Section F Low 24192353
2017 Pleiotropic neuropathological alterations in Myo5a-mutant rats (lacking Myo5a protein in brain) include hyperphosphorylation of alpha-synuclein and tau, accumulation of the dopamine metabolite DOPAL due to decreased aldehyde dehydrogenase activity, and alpha-synuclein accumulation in mitochondria of dopaminergic neurons associated with impaired respiratory complex I and IV activity, linking Myo5a-dependent organelle transport to neurodegeneration. Rat knockout model, immunohistochemistry, biochemical assays for respiratory complex activity, DOPAL measurement, phosphoprotein analysis Brain research Medium 29217155
2021 Novel mutations in Myo5a in C57BL/6 mice cause coat color dilution by reducing full-length Myo5a transcript and protein levels, resulting in deficient melanosome transport, directly linking Myo5a expression level to melanosome peripheral distribution. Whole-genome sequencing, RNA-seq, RT-qPCR, protein level measurement, melanosome transport assay FASEB journal Medium 33715225
2025 A splice variant in exon 14 of Myo5a (c.1752g>a) that ablates MYO5A protein expression causes rapidly progressive ataxia with cerebellar Purkinje cell pathology; mass spectrometry of cerebellar extracts from Myo5a-null mice identified differentially abundant proteins involved in early endosome transport, and co-immunoprecipitation provided evidence for an interaction between MYO5A and ANKFY1, an effector for the endosomal protein RAB5A; additionally, neurons from Myo5a-null mice had elongated mitochondria, linking MYO5A to mitochondrial homeostasis. Genome sequencing, genome-wide mapping, mass spectrometry proteomics, co-immunoprecipitation, primary neuron imaging FASEB journal Medium 40022605
2015 High-throughput affinity-purification mass spectrometry (BioPlex) identified interaction partners of MYO5A in HEK293T cells, placing it within a network of proteins consistent with its role in intracellular transport. Affinity purification–mass spectrometry (AP-MS) at proteome scale Cell Low 26186194
1994 The human MYH12 gene (now MYO5A) was cloned from a human brain cDNA library and mapped to chromosome 15q21; the sequence is 95.8% identical to the mouse dilute gene at the amino acid level, confirming evolutionary conservation of the myosin Va motor. PCR cloning from cDNA library, somatic cell hybrid analysis, in situ hybridization Genomics Medium 7835087 8188282

Source papers

Stage 0 corpus · 83 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2015 The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell 1118 26186194
2017 Architecture of the human interactome defines protein communities and disease networks. Nature 1085 28514442
2015 A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell 1015 26496610
2012 The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Molecular cell 973 22681889
2018 VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell discovery 829 29507755
2003 Complete sequencing and characterization of 21,243 full-length human cDNAs. Nature genetics 754 14702039
2021 Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Cell 705 33961781
2011 Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Briefings in bioinformatics 656 21873635
1999 Myosin-V is a processive actin-based motor. Nature 613 10448864
2020 Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms. Science (New York, N.Y.) 564 33060197
2001 Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis. Science (New York, N.Y.) 501 11546872
2022 OpenCell: Endogenous tagging for the cartography of human cellular organization. Science (New York, N.Y.) 432 35271311
2015 Panorama of ancient metazoan macromolecular complexes. Nature 407 26344197
1996 Normalization and subtraction: two approaches to facilitate gene discovery. Genome research 401 8889548
1997 Griscelli disease maps to chromosome 15q21 and is associated with mutations in the myosin-Va gene. Nature genetics 344 9207796
2021 A proximity-dependent biotinylation map of a human cell. Nature 339 34079125
2002 Slac2-a/melanophilin, the missing link between Rab27 and myosin Va: implications of a tripartite protein complex for melanosome transport. The Journal of biological chemistry 299 11856727
2017 Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. Proceedings of the National Academy of Sciences of the United States of America 282 28611215
2002 A family of Rab27-binding proteins. Melanophilin links Rab27a and myosin Va function in melanosome transport. The Journal of biological chemistry 268 11980908
2022 Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration. Cell 256 35063084
2003 Griscelli syndrome restricted to hypopigmentation results from a melanophilin defect (GS3) or a MYO5A F-exon deletion (GS1). The Journal of clinical investigation 218 12897212
2008 Motor protein-dependent transport of AMPA receptors into spines during long-term potentiation. Nature neuroscience 206 18311135
2000 Interaction of the postsynaptic density-95/guanylate kinase domain-associated protein complex with a light chain of myosin-V and dynein. The Journal of neuroscience : the official journal of the Society for Neuroscience 196 10844022
1996 Synthetic lethality screen identifies a novel yeast myosin I gene (MYO5): myosin I proteins are required for polarization of the actin cytoskeleton. The Journal of cell biology 196 8682864
2020 Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions. Nature cell biology 194 32203420
2002 Identification of mRNA/protein (mRNP) complexes containing Puralpha, mStaufen, fragile X protein, and myosin Va and their association with rough endoplasmic reticulum equipped with a kinesin motor. The Journal of biological chemistry 188 12147688
1998 The localization of myosin VI at the golgi complex and leading edge of fibroblasts and its phosphorylation and recruitment into membrane ruffles of A431 cells after growth factor stimulation. The Journal of cell biology 171 9852149
2001 The 8-kDa dynein light chain binds to its targets via a conserved (K/R)XTQT motif. The Journal of biological chemistry 155 11148209
2004 Rab GTPases and myosin motors in organelle motility. Traffic (Copenhagen, Denmark) 152 15117313
2002 Human myosin-Vc is a novel class V myosin expressed in epithelial cells. Journal of cell science 149 11870218
1994 Identification and overlapping expression of multiple unconventional myosin genes in vertebrate cell types. Proceedings of the National Academy of Sciences of the United States of America 149 8022818
2012 Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription. Molecular & cellular proteomics : MCP 145 22586326
2005 The two senescence-related markers, GS1 (cytosolic glutamine synthetase) and GDH (glutamate dehydrogenase), involved in nitrogen mobilization, are differentially regulated during pathogen attack and by stress hormones and reactive oxygen species in Nicotiana tabacum L. leaves. Journal of experimental botany 111 16377736
2016 Cytosolic Glutamine Synthetase Gln1;2 Is the Main Isozyme Contributing to GS1 Activity and Can Be Up-Regulated to Relieve Ammonium Toxicity. Plant physiology 87 27231101
2020 Exosomes Derived from Brain Metastatic Breast Cancer Cells Destroy the Blood-Brain Barrier by Carrying lncRNA GS1-600G8.5. BioMed research international 83 32337272
2002 Evidence that Griscelli syndrome with neurological involvement is caused by mutations in RAB27A, not MYO5A. American journal of human genetics 60 12058346
2001 Constitutive overexpression of cytosolic glutamine synthetase (GS1) gene in transgenic alfalfa demonstrates that GS1 may be regulated at the level of RNA stability and protein turnover. Plant physiology 49 11351075
2004 dsu functions in a MYO5A-independent pathway to suppress the coat color of dilute mice. Proceedings of the National Academy of Sciences of the United States of America 42 15550542
2005 The two nitrogen mobilisation- and senescence-associated GS1 and GDH genes are controlled by C and N metabolites. Planta 41 15654637
2001 Binding of Griffonia simplicifolia 1 isolectin B4 (GS1 B4) to alpha-galactose antigens. Immunology and cell biology 37 11264704
1994 Cloning, analysis, and chromosomal localization of myoxin (MYH12), the human homologue to the mouse dilute gene. Genomics 36 8188282
2014 Impact of concurrent overexpression of cytosolic glutamine synthetase (GS1) and sucrose phosphate synthase (SPS) on growth and development in transgenic tobacco. Planta 35 25213117
2008 Bioremoval of hexavalent chromium from water by a salt tolerant bacterium, Exiguobacterium sp. GS1. Journal of industrial microbiology & biotechnology 34 18663504
2006 The 3' untranslated region of a soybean cytosolic glutamine synthetase (GS1) affects transcript stability and protein accumulation in transgenic alfalfa. The Plant journal : for cell and molecular biology 31 16460515
2001 Bioconversion of limonene to increased concentrations of perillic acid by Pseudomonas putida GS1 in a fed-batch reactor. Applied microbiology and biotechnology 30 11499915
1998 Identification of translin and trax as components of the GS1 strand-specific DNA binding complex enriched in brain. Journal of neurochemistry 30 9681436
2020 LINC01980 facilitates esophageal squamous cell carcinoma progression via regulation of miR-190a-5p/MYO5A pathway. Archives of biochemistry and biophysics 28 32325088
2000 The mouse neurological mutant flailer expresses a novel hybrid gene derived by exon shuffling between Gnb5 and Myo5a. Human molecular genetics 24 10749990
2022 Multi-Omics Techniques for Analysis Antifungal Mechanisms of Lipopeptides Produced by Bacillus velezensis GS-1 against Magnaporthe oryzae In Vitro. International journal of molecular sciences 22 35409115
2018 MYO5A inhibition by miR-145 acts as a predictive marker of occult neck lymph node metastasis in human laryngeal squamous cell carcinoma. OncoTargets and therapy 18 29950866
2012 Inactivation of the transcriptional regulator-encoding gene sdiA enhances rice root colonization and biofilm formation in Enterobacter cloacae GS1. Journal of bacteriology 18 23086212
1990 Phytochrome-mediated activation of the gene for cytosolic glutamine-synthetase (GS1) during imbibition of photosensitive lettuce seeds. Plant molecular biology 17 1983300
2018 Assessment of fish iridoviruses using a novel cell line GS-1, derived from the spleen of orange-spotted grouper Epinephelus coioides (Hamilton) and susceptible to ranavirus and megalocytivirus. The Journal of veterinary medical science 15 30224575
2010 Candida albicans Vrp1 is required for polarized morphogenesis and interacts with Wal1 and Myo5. Microbiology (Reading, England) 14 20656786
2022 Cytosolic Glutamine Synthetase GS1;3 Is Involved in Rice Grain Ripening and Germination. Frontiers in plant science 13 35211144
2017 Pleiotropic neuropathological and biochemical alterations associated with Myo5a mutation in a rat Model. Brain research 12 29217155
2000 Microbial degradation of disodium terephthalate by alkaliphilic Dietzia sp. strain GS-1. Bioscience, biotechnology, and biochemistry 12 11210143
2016 Efficient hydroxylation of 1,8-cineole with monoterpenoid-resistant recombinant Pseudomonas putida GS1. World journal of microbiology & biotechnology 11 27263007
1998 The maize glutamine synthetase GS1-2 gene is preferentially expressed in kernel pedicels and is developmentally-regulated. Plant & cell physiology 11 9615467
1995 Cloning and regional assignment of the human myosin heavy chain 12 (MYH12) gene to chromosome band 15q21. Cytogenetics and cell genetics 11 7835087
2022 Fatal melanoma with a novel MYO5A-BRAF fusion and small associated conventional nevus: A case report and review of literature. Journal of cutaneous pathology 10 35596628
2021 Novel mutations in the Myo5a gene cause a dilute coat color phenotype in mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 10 33715225
2019 Function of Brassica napus BnABI3 in Arabidopsis gs1, an Allele of AtABI3, in Seed Development and Stress Response. Frontiers in plant science 10 30804960
2010 The 3' untranslated region of the two cytosolic glutamine synthetase (GS(1)) genes in alfalfa (Medicago sativa) regulates transcript stability in response to glutamine. Planta 10 20706735
2021 MYO5A Frameshift Variant in a Miniature Dachshund with Coat Color Dilution and Neurological Defects Resembling Human Griscelli Syndrome Type 1. Genes 9 34680875
2020 Central nervous system ganglioneuroblastoma harboring MYO5A-NTRK3 fusion. Brain tumor pathology 8 32556925
2023 circFNDC3B promotes esophageal squamous cell carcinoma progression by targeting MYO5A via miR-370-3p/miR-136-5p. BMC cancer 7 37667251
2014 Permanent draft genome sequence of Geobacillus thermocatenulatus strain GS-1. Marine genomics 6 25280889
2005 Highly effective expression of glutamine synthetase genes GS1 and GS2 in transgenic rice plants increases nitrogen-deficiency tolerance. Zhi wu sheng li yu fen zi sheng wu xue xue bao = Journal of plant physiology and molecular biology 6 16222091
2023 MYO5A overexpression promotes invasion and correlates with low lymphocyte infiltration in head and neck squamous carcinoma. BMC cancer 5 38129784
2023 Circ-FNDC3B Functions as an Oncogenic Factor in Esophageal Squamous Cell Carcinoma via Upregulating MYO5A by Absorbing miR-136-5p and miR-370-3p. Biochemical genetics 4 36884165
1997 Cloning and sequencing of ribosomal protein L27a and a gene similar to human GS1 in Drosophila. Gene 3 9055824
2016 Kinetic commitment in the catalysis of glutamine synthesis by GS1 from Arabidopsis using 14N/15N and solvent isotope effects. Plant physiology and biochemistry : PPB 2 27448794
1998 Loss of heterozygosity at the dilute-short ear (Myo5a-Bmp5) region of the mouse: mitotic recombination or double non-disjunction? Genetical research 2 10036975
2023 Development and marker-trait relationships of functional markers for glutamine synthetase GS1 and GS2 homoeogenes in bread wheat. Molecular breeding : new strategies in plant improvement 1 37309364
2019 Whole-Genome Sequence of Corynebacterium xerosis Strain GS1, Isolated from Yak in Gansu Province, China. Microbiology resource announcements 1 31515333
2026 Safety, pharmacokinetics, and pharmacodynamics of GS1-144, a neurokinin-3 receptor antagonist: A randomized phase 1 single and multiple ascending dose and food effect study. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 0 41539370
2026 Efficacy and safety of GS1-144, a novel neurokinin 3 receptor antagonist, for moderate-to-severe vasomotor symptoms associated with menopause in Chinese women: a randomized, double-blind, placebo-controlled phase 2 trial. Menopause (New York, N.Y.) 0 41979542
2025 A novel, rapidly progressive ataxia due to a spontaneous Myo5a mutation in mice impairs transport proteins and alters mitochondria. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 0 40022605
2024 Rare variant of large pediatric glioneuronal tumor with novel MYO5A::NTRK3 fusion: illustrative case. Journal of neurosurgery. Case lessons 0 38437672
2023 MYO5A Inhibition by miR-145 Acts as a Predictive Marker of Occult Neck Lymph Node Metastasis in Human Laryngeal Squamous Cell Carcinoma [Retraction]. OncoTargets and therapy 0 37694106
2013 Purification, crystallization and preliminary crystallographic analysis of the globular domain of the human type V myosin Myo5a. Acta crystallographica. Section F, Structural biology and crystallization communications 0 24192353
1995 Modulation of oligosaccharide structure of a pro-urokinase derivative (pro-UK delta GS1) by changing culture conditions of a lymphoblastoid cell line Namalwa KJM-1 adapted to serum-free medium. Cytotechnology 0 8987501