Affinage

AP2A2

AP-2 complex subunit alpha-2 · UniProt O94973

Round 2 corrected
Length
939 aa
Mass
104.0 kDa
Annotated
2026-04-28
64 papers in source corpus 15 papers cited in narrative 15 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

AP2A2 (alpha2-adaptin) is a core subunit of the heterotetrameric AP-2 clathrin adaptor complex that drives clathrin-mediated endocytosis at the plasma membrane, recruiting accessory proteins such as epsin and amphiphysin through its alpha-appendage domain and binding polyphosphoinositides to anchor the complex at the membrane (PMID:12086608, PMID:9723620, PMID:8552632). A conformational change in the AP-2 core, triggered by mu2 phosphorylation, exposes the Yxxφ cargo-binding site, enabling internalization of receptors including β-adrenergic receptors—whose AP2A2-dependent endocytosis controls adipocyte lipolysis—and transferrin receptor in neurons (PMID:12086608, PMID:31533003, PMID:38772452). AP2A2-mediated endocytosis is exploited by pathogens: HIV-1 Nef co-opts AP-2 to downregulate CD4, and Listeria monocytogenes LLO engages the AP2A2 PEST-binding site to clear pore-forming toxin from the host membrane (PMID:2014082, PMID:29902442, PMID:40847839). Loss-of-function mutations in AP2A2 cause a form of hereditary spastic paraplegia, with patient iPSC-derived neurons showing impaired clathrin-mediated endocytosis and altered axon initial segment length, and Xenopus ap2a2 knockout recapitulating neurological defects (PMID:38772452).

Mechanistic history

Synthesis pass · year-by-year structured walk · 10 steps
  1. 1991 High

    Establishing that the AP-2 endocytic machinery could be co-opted by a viral protein: HIV-1 Nef was shown to downregulate surface CD4 through AP-2-dependent endocytosis independently of CD4 phosphorylation, revealing that pathogens exploit clathrin-mediated internalization.

    Evidence Retroviral Nef expression in lymphocytic cell lines with flow cytometry and CD4 phosphorylation-site mutagenesis

    PMID:2014082

    Open questions at the time
    • Precise molecular interface between Nef and AP-2 subunits not defined
    • Contribution of AP2A2 versus AP2A1 isoform not resolved
  2. 1996 High

    Identification of amphiphysin as a direct partner of AP2A2 linked the adaptor complex to synaptic vesicle recycling and began cataloguing the alpha-appendage interactome.

    Evidence Gel overlay, affinity chromatography, and co-immunoprecipitation from brain extracts

    PMID:8552632

    Open questions at the time
    • Binding site on alpha-adaptin not mapped at residue level
    • Functional consequence of disrupting this specific interaction not tested in vivo
  3. 1998 High

    Discovery that epsin binds alpha-adaptin and is required for clathrin-mediated endocytosis established that the AP2A2 appendage domain serves as a platform to recruit essential accessory factors.

    Evidence Affinity chromatography and co-IP from brain extracts, functional disruption of epsin blocking endocytosis

    PMID:9723620

    Open questions at the time
    • Structural basis of epsin–alpha-appendage interaction not yet determined
    • Redundancy with AP2A1 not assessed
  4. 2002 High

    The 2.6 Å crystal structure of the AP-2 core resolved how the complex is organized, identified two polyphosphoinositide-binding sites (on alpha and mu2 subunits), and revealed that the Yxxφ cargo-binding pocket is occluded in the inactive conformation—requiring mu2 phosphorylation-induced conformational change for activation.

    Evidence X-ray crystallography of the 200 kDa AP-2 core with inositolhexakisphosphate

    PMID:12086608

    Open questions at the time
    • Structure captured the locked conformation; open/active-state structure not yet solved at this time
    • Contribution of alpha2 versus alpha1 isoform to PI binding kinetics not distinguished
  5. 2011 Medium

    Beyond endocytosis, AP2A2 was found to segregate asymmetrically during hematopoietic stem cell division and to positively regulate HSC self-renewal, raising the possibility of a non-canonical fate-determinant role.

    Evidence Functional screen of 73 polarity genes with in vitro-to-in vivo HSC assay and live-cell videomicroscopy of cytokinesis

    PMID:22174158

    Open questions at the time
    • Mechanism by which AP2A2 asymmetry controls HSC fate is unknown
    • In vivo confirmation in conditional KO HSCs not performed
    • Whether this role requires endocytic activity is untested
  6. 2018 High

    The molecular basis of pathogen exploitation was extended: Listeria LLO was shown to engage AP2A2 via a PEST-like sequence, co-opting clathrin-mediated endocytosis to clear cytotoxic pores from the host membrane—a mechanism functionally interchangeable with GPCR PEST motifs.

    Evidence Co-immunoprecipitation of LLO–AP2A2, siRNA knockdown with cytotoxicity phenotype, heterologous PEST-sequence complementation

    PMID:29902442

    Open questions at the time
    • Structural details of the AP2A2 PEST-binding pocket not resolved
    • Whether AP2A1 can substitute for AP2A2 in LLO clearance not tested
  7. 2019 High

    Adipocyte-specific Ap2a2 knockout demonstrated that AP2A2-dependent endocytosis of β2- and β3-adrenergic receptors is required for cAMP/PKA-driven lipolysis, placing AP2A2 as a PPARα target gene that connects transcriptional regulation to receptor trafficking in fat.

    Evidence Conditional KO mouse with lipolysis assays, cAMP/PKA measurements, receptor surface flow cytometry, PPARα agonist treatment

    PMID:31533003

    Open questions at the time
    • Whether signaling from internalized β-AR endosomes is the key mechanism or simply surface density effects is not resolved
    • Relevance to human adipose physiology not confirmed
  8. 2020 Medium

    Isoform-specific neuropathological mapping showed AP2A2 co-localizes with neurofibrillary tangles and microglial cells in late-onset Alzheimer's disease brains, with altered detergent solubility, distinguishing it from AP2A1's pathological associations.

    Evidence Double-label immunofluorescence, quantitative digital pathology, detergent fractionation across multiple cohorts

    PMID:31748784 PMID:34820873

    Open questions at the time
    • Causal role of AP2A2 in AD pathogenesis versus bystander accumulation not established
    • Mechanism linking AP2A2 to tangle biology or microglial endocytosis not defined
  9. 2024 High

    A homozygous AP2A2 missense variant was identified as the cause of hereditary spastic paraplegia, with patient neurons showing reduced AP2A2 protein, impaired transferrin receptor endocytosis, defective accessory protein binding, and altered axon initial segment length—confirmed by Xenopus knockout recapitulating neurological deficits.

    Evidence WES in consanguineous family, iPSC-derived neuron functional assays, mutant appendage-domain immunoprecipitation, Xenopus CRISPR KO

    PMID:38772452

    Open questions at the time
    • Whether other HSP-causing genes converge on AP2A2-dependent endocytic pathways is unknown
    • Neuropathological characterization of the animal model is limited
    • Rescue by wild-type AP2A2 re-expression not reported
  10. 2025 High

    CRISPR knockout of Ap2a2 in macrophages inhibited intracellular Listeria proliferation, extending the 2018 toxin-clearance finding to show that the entire AP-2 complex facilitates post-phagosomal bacterial replication independently of cell-to-cell spread.

    Evidence CRISPR KO of Ap2a2/Ap2m1/Ap2s1 in multiple cell lines, intracellular bacterial proliferation assay, label-free proteomics

    PMID:40847839

    Open questions at the time
    • Specific cargo whose AP2A2-dependent endocytosis enables Listeria cytosolic replication is not identified
    • In vivo infection model not tested

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key unresolved questions include the structural basis for AP2A2 versus AP2A1 isoform-specific functions, whether AP2A2's role in HSC asymmetric division is endocytosis-dependent, the causal contribution of AP2A2 to Alzheimer's disease pathogenesis, and identification of the full spectrum of AP2A2-specific cargo beyond β-ARs and transferrin receptor.
  • No structure distinguishing AP2A2 from AP2A1 appendage domains
  • Endocytosis-independent functions not formally tested
  • Genotype–phenotype spectrum for AP2A2-related HSP unknown

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060090 molecular adaptor activity 6 GO:0005198 structural molecule activity 2 GO:0008289 lipid binding 1
Localization
GO:0005886 plasma membrane 4 GO:0031410 cytoplasmic vesicle 3 GO:0005829 cytosol 1
Pathway
R-HSA-5653656 Vesicle-mediated transport 7 R-HSA-112316 Neuronal System 3 R-HSA-168256 Immune System 3 R-HSA-162582 Signal Transduction 1
Partners
ADRB2AMPHAP2B1AP2M1AP2S1EPN1SDC2
Complex memberships
AP-2 clathrin adaptor complex

Evidence

Reading pass · 15 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2002 Crystal structure of the 200 kDa AP2 core complex (comprising alpha trunk [AP2A2/AP2A1], beta2 trunk, mu2, and sigma2 subunits) complexed with inositolhexakisphosphate was solved at 2.6 Å resolution. Two polyphosphoinositide binding sites were identified, one on the alpha subunit and one on mu2. The binding site for Yxxφ endocytic motifs was found to be buried in the core structure, indicating that a conformational change—likely triggered by phosphorylation in the mu2 linker—is required for cargo motif binding. A model for AP2 recruitment and activation at the plasma membrane was proposed. X-ray crystallography at 2.6 Å, structural modeling Cell High 12086608
1998 Epsin was identified as a binding partner for alpha-adaptin (AP2A2-containing subunit of AP-2). Epsin co-precipitates with AP-2 and Eps15 from brain extracts. The central region of epsin directly binds AP-2. Disruption of epsin function blocks clathrin-mediated endocytosis, establishing that the epsin–alpha-adaptin interaction is functionally required for endocytosis. Affinity chromatography, co-immunoprecipitation from brain extracts, functional disruption assay Nature High 9723620
1996 Amphiphysin was shown to bind the alpha-C subunit of AP-2 adaptin (AP2A2) via a region distinct from its SH3 domain. The interaction was demonstrated by gel overlay and affinity chromatography, and the two proteins were co-precipitated from brain extracts, supporting in situ interaction in nerve terminals and implicating the amphiphysin–AP2A2 interaction in synaptic vesicle endocytosis. Gel overlay, affinity chromatography, co-immunoprecipitation from brain extracts, co-localization by immunofluorescence Proceedings of the National Academy of Sciences of the United States of America High 8552632
1991 HIV-1 Nef was shown to downregulate cell-surface CD4 through a mechanism involving the endocytic machinery including AP-2 (alpha-adaptin/AP2A2), acting independently of CD4 serine phosphorylation. Nef expression reduced surface CD4 without altering steady-state CD4 RNA or total protein, establishing that Nef co-opts AP-2-mediated endocytosis to internalize CD4. Retroviral vector expression in lymphocytic cell lines, flow cytometry, Western blot, mutagenesis of CD4 phosphorylation sites Nature High 2014082
2011 AP2A2 was identified as a positive regulator of hematopoietic stem cell (HSC) function in an in vitro-to-in vivo screen of 73 polarity candidate genes. Live-cell videomicroscopy demonstrated that AP2A2 protein segregates asymmetrically during HSC/progenitor cell cytokinesis, suggesting it functions as a fate determinant partitioned unequally between daughter cells during asymmetric cell division to regulate HSC self-renewal. In vitro to in vivo functional screen (altered HSC fate assay), live-cell videomicroscopy of cytokinesis Blood Medium 22174158
2018 LLO (Listeriolysin O) from Listeria monocytogenes interacts with AP2A2 via its PEST-like sequence. This interaction recruits AP2A2-dependent clathrin-mediated endocytosis to remove LLO from the inner plasma membrane leaflet, where it otherwise forms cytotoxic pores. Ap2a2-dependent endocytosis is required to prevent LLO-induced host cell death. An unrelated PEST-like sequence from a human GPCR that also binds AP2A2 could functionally substitute for the LLO PEST sequence, confirming the specificity of this interaction. Co-immunoprecipitation (LLO–AP2A2 interaction), siRNA knockdown of Ap2a2, cytotoxicity assays, heterologous PEST-sequence complementation experiment Cell host & microbe High 29902442
2019 Adipocyte-specific knockout of Ap2a2 in mice revealed that AP2A2 is required for β-adrenergic receptor (β2-AR and β3-AR) internalization in adipose tissue. Loss of Ap2a2 caused increased cell-surface localization of β2- and β3-ARs, impaired cAMP response, reduced PKA activation, and markedly decreased glycerol/fatty acid release upon β-adrenergic stimulation, demonstrating that AP2A2-mediated clathrin endocytosis controls lipolysis. AP2A2 was identified as a PPARα target gene, linking PPARα signaling to β-adrenergic regulation of adipose lipolysis. Adipocyte-specific conditional knockout mouse, lipolysis assays (glycerol/fatty acid release), cAMP measurement, PKA activation assay, flow cytometry for receptor surface localization, PPARα agonist treatment (WY-14643) FASEB journal High 31533003
2016 AP2A2 (along with AP2A1 and AP2B1) was identified as part of the EGFR interactome in non-small cell lung cancer cells (HCC4006), with increased levels of AP2 complex proteins detected by affinity purification–mass spectrometry in erlotinib-resistant cells, suggesting AP2A2-mediated endocytosis of EGFR is altered in drug resistance. Affinity purification coupled with high-resolution mass spectrometry (AP-MS) of EGFR interactome European journal of pharmaceutical sciences Low 27112992
2021 Immunohistochemical and immunofluorescence analyses in human brains demonstrated isoform-specific localization of alpha-adaptin proteins: AP2A1 co-localizes with tau pathology (neurofibrillary tangles) in late-onset Alzheimer's disease brains, whereas AP2A2 co-localizes specifically with microglial cells. AP2A2 was present in the detergent-insoluble fraction from cognitively impaired brains, indicating altered solubility in disease. Immunoblot after AP2A1/AP2A2 plasmid transfection (antibody validation), immunohistochemistry, immunofluorescence with digital quantification of co-localization, detergent fractionation Neuropathology and applied neurobiology Medium 34820873
2020 AP2A2 protein was found to co-localize with neurofibrillary tangles in late-onset Alzheimer's disease brains by double-label immunofluorescence, but not with pTau in progressive supranuclear palsy or TDP-43 proteinopathy, indicating disease-specific and isoform-specific association. AP2A2 expression was lower in brain samples from persons with longer MUC6 VNTR regions. Double-label immunofluorescence, quantitative digital pathology, RT-PCR expression analysis Journal of neuropathology and experimental neurology Medium 31748784
2020 AP2A2 was identified as a novel interaction partner of cardiac syndecan-2 in rat left ventricle by affinity purification mass spectrometry (three complementary methods), and the interaction was independently verified by co-immunoprecipitation in HEK293 cells. Three-method affinity purification mass spectrometry (rat left ventricle), co-immunoprecipitation verification in HEK293 cells Frontiers in cell and developmental biology Medium 32984315
2024 A homozygous missense variant in AP2A2 was identified in a Malian family with hereditary spastic paraplegia (HSP). In patient iPSC-derived neurons: (1) AP2A2 protein levels were reduced (Western blot); (2) transferrin receptor endocytosis was decreased, demonstrating defective clathrin-mediated endocytosis; (3) axon initial segment length was increased. Immunoprecipitation of the mutant AP-2 appendage alpha-C domain showed defective binding to accessory endocytic proteins. Xenopus tropicalis ap2a2 knockout tadpoles developed cerebral edema and progressive seizures. This establishes AP2A2 loss-of-function as the cause of a novel HSP genetic entity. Whole exome sequencing, Western blot, transferrin receptor endocytosis assay in patient iPSC-derived neurons, axon initial segment measurement, immunoprecipitation of mutant AP-2 appendage domain, Xenopus ap2a2 CRISPR knockout Neurobiology of disease High 38772452
2025 CRISPR/Cas9 knockout of Ap2a2 (along with Ap2m1 and Ap2s1) in macrophage and epithelial cell lines markedly inhibited intracellular L. monocytogenes proliferation. Proteomic analysis showed Ap2a2 cooperates with Ap2m1 and Ap2s1 during infection. AP-2 complex facilitates post-phagosomal cytosolic replication independently of bacterial cell-to-cell spread, identifying AP2A2 as a host factor exploited by the pathogen. CRISPR/Cas9 knockout (Ap2a2, Ap2m1, Ap2s1), quantitative intracellular bacterial proliferation assay, label-free proteomics, in vitro infection model (Raw264.7 macrophages, DC2.4, HeLa, Caco-2) Proteomics High 40847839
2025 siRNA-mediated knockdown of Ap2a2 in disease-relevant Psen2-knockdown BV2 microglial cells altered cellular phenotypes and reversed AD-associated proteomic patterns, identifying Ap2a2 as one of five targets (alongside Pdhb, Pdha1, Dlat, Psmc3) that impacted both phenotypic and proteomic responses in an Alzheimer's disease context. siRNA knockdown in BV2 Psen2-KD microglial cells, cellular phenotypic assays, quantitative proteomics Alzheimer's & dementia Medium 41388808
2024 AP2A2 protein was identified by label-free proteomics as significantly downregulated in cortical synaptosomes of rats with vascular dementia (bilateral carotid artery occlusion model), clustering with other AP-2 complex subunits (AP2B1, AP2M1, AP2S1) and clathrin heavy chain as hub proteins in the synaptic vesicle cycle network, suggesting disruption of AP2A2-dependent endocytosis at synapses underlies VaD-associated synaptopathy. Synaptosome isolation, label-free proteomics, PPI network hub analysis, Western blot validation of related proteins Molecular neurobiology Low 38990251

Source papers

Stage 0 corpus · 64 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2013 Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease. Nature genetics 3440 24162737
2020 A SARS-CoV-2 protein interaction map reveals targets for drug repurposing. Nature 3411 32353859
2012 Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 1718 22658674
2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America 1479 12477932
2015 The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell 1118 26186194
2017 Architecture of the human interactome defines protein communities and disease networks. Nature 1085 28514442
2015 A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell 1015 26496610
2020 A reference map of the human binary protein interactome. Nature 849 32296183
2003 Complete sequencing and characterization of 21,243 full-length human cDNAs. Nature genetics 754 14702039
1991 Serine phosphorylation-independent downregulation of cell-surface CD4 by nef. Nature 716 2014052
2021 Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Cell 705 33961781
2012 A census of human soluble protein complexes. Cell 689 22939629
2015 Gene essentiality and synthetic lethality in haploid human cells. Science (New York, N.Y.) 657 26472760
2011 Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Briefings in bioinformatics 656 21873635
2018 High-Density Proximity Mapping Reveals the Subcellular Organization of mRNA-Associated Granules and Bodies. Molecular cell 580 29395067
2020 Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms. Science (New York, N.Y.) 564 33060197
2002 Molecular architecture and functional model of the endocytic AP2 complex. Cell 495 12086608
1994 Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. Gene 492 8125298
1998 Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis. Nature 490 9723620
2000 Clathrin. Annual review of biochemistry 471 10966473
2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome research 438 15489334
2022 OpenCell: Endogenous tagging for the cartography of human cellular organization. Science (New York, N.Y.) 432 35271311
2015 Panorama of ancient metazoan macromolecular complexes. Nature 407 26344197
1996 Normalization and subtraction: two approaches to facilitate gene discovery. Genome research 401 8889548
2013 Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. Science signaling 383 24255178
2011 HIV-1 envelope glycoprotein biosynthesis, trafficking, and incorporation. Journal of molecular biology 362 21762802
2007 Functional specialization of beta-arrestin interactions revealed by proteomic analysis. Proceedings of the National Academy of Sciences of the United States of America 360 17620599
1996 A role of amphiphysin in synaptic vesicle endocytosis suggested by its binding to dynamin in nerve terminals. Proceedings of the National Academy of Sciences of the United States of America 359 8552632
2021 A proximity-dependent biotinylation map of a human cell. Nature 339 34079125
1998 Huntingtin interacts with a family of WW domain proteins. Human molecular genetics 338 9700202
2011 Asymmetric segregation and self-renewal of hematopoietic stem and progenitor cells with endocytic Ap2a2. Blood 70 22174158
2017 Epigenome-wide association study of asthma and wheeze in childhood and adolescence. Clinical epigenetics 57 29046734
2014 Genetic susceptibility for chronic bronchitis in chronic obstructive pulmonary disease. Respiratory research 44 25241909
2018 The Listeriolysin O PEST-like Sequence Co-opts AP-2-Mediated Endocytosis to Prevent Plasma Membrane Damage during Listeria Infection. Cell host & microbe 41 29902442
2020 Alzheimer Disease Pathology-Associated Polymorphism in a Complex Variable Number of Tandem Repeat Region Within the MUC6 Gene, Near the AP2A2 Gene. Journal of neuropathology and experimental neurology 25 31748784
2020 The MUC6/AP2A2 Locus and Its Relevance to Alzheimer's Disease: A Review. Journal of neuropathology and experimental neurology 25 32357373
2020 DNA methylation microarrays identify epigenetically regulated lipid related genes in obese patients with hypercholesterolemia. Molecular medicine (Cambridge, Mass.) 21 33028190
2019 The role of Ap2a2 in PPARα-mediated regulation of lipolysis in adipose tissue. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 21 31533003
2016 Utilising the EGFR interactome to identify mechanisms of drug resistance in non-small cell lung cancer - Proof of concept towards a systems pharmacology approach. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 21 27112992
2018 In silico epigenetics of metal exposure and subclinical atherosclerosis in middle aged men: pilot results from the Aragon Workers Health Study. Philosophical transactions of the Royal Society of London. Series B, Biological sciences 20 29685964
1986 Characterization of retrograde conduction by direct endocardial recording from an accessory atrioventricular pathway. Journal of the American College of Cardiology 20 3941206
2018 Genome-wide association study in Finnish twins highlights the connection between nicotine addiction and neurotrophin signaling pathway. Addiction biology 19 29532581
2022 Blood DNA Methylation Patterns in Older Adults With Evolving Dementia. The journals of gerontology. Series A, Biological sciences and medical sciences 16 35299244
2021 Lung expression of genes putatively involved in SARS-CoV-2 infection is modulated in cis by germline variants. European journal of human genetics : EJHG 15 33649539
2021 Alpha adaptins show isoform-specific association with neurofibrillary tangles in Alzheimer's disease. Neuropathology and applied neurobiology 15 34820873
2018 Association of Candidate Genes with Response to Heat and Newcastle Disease Virus. Genes 14 30463235
2017 Analytical Strategy to Prioritize Alzheimer's Disease Candidate Genes in Gene Regulatory Networks Using Public Expression Data. Journal of Alzheimer's disease : JAD 11 28800327
2013 The effect of clozapine on mRNA expression for genes encoding G protein-coupled receptors and the protein components of clathrin-mediated endocytosis. Psychiatric genetics 11 23811784
2020 Possible key microRNAs and corresponding molecular mechanisms for atrial fibrillation. Anatolian journal of cardiology 10 32478689
2024 An Insulin-Chromogranin A Hybrid Peptide Activates DR11-Restricted T Cells in Human Type 1 Diabetes. Diabetes 7 38295386
2020 The Cardiac Syndecan-2 Interactome. Frontiers in cell and developmental biology 7 32984315
2018 A genetic variant near adaptor-related protein complex 2 alpha 2 subunit gene is associated with coronary artery disease in a Chinese population. BMC cardiovascular disorders 6 30086706
2024 AP2A2 mutation and defective endocytosis in a Malian family with hereditary spastic paraplegia. Neurobiology of disease 4 38772452
2023 Genetic analyses of chr11p15.5 region identify MUC5AC-MUC5B associated with asthma-related phenotypes. The Journal of asthma : official journal of the Association for the Care of Asthma 4 36946148
2023 Exploring the Synergistic Mechanism of AP2A2 Transcription Factor Inhibition via Molecular Modeling and Simulations as a Novel Computational Approach for Combating Breast Cancer: In Silico Interpretations. Molecular biotechnology 4 37747672
2024 Genome-wide association study reveals the candidate genes of humerus quality in laying duck. Poultry science 3 38806002
2025 Whole-genome sequencing reveals the impact of lipid pathway and APOE genotype on brain amyloidosis. Human molecular genetics 2 39927718
2024 Synaptic Vesicle-Related Proteins and Ubiquilin 2 in Cortical Synaptosomes Mediate Cognitive Impairment in Vascular Dementia Rats. Molecular neurobiology 2 38990251
2025 Proteomics Reveals AP-2 Complex Depletion Suppressing Listeria monocytogenes Intracellular Replication. Proteomics 1 40847839
2025 Integrated phenotypic and proteomic screening identifies top-tier Alzheimer's disease therapeutic targets. Alzheimer's & dementia : the journal of the Alzheimer's Association 1 41388808
2026 Unveiling the molecular mechanisms of burn injury through integrated single-cell and bulk transcriptomic analysis. PloS one 0 41592030
2026 Epigenetic Alterations Beyond CpG Islands in Periodontitis: In Silico Study of DNA Methylation Data. Clinical and experimental dental research 0 41818416
2025 Integrated phenotypic and proteomic screening identifies top-tier Alzheimer's disease therapeutic targets. bioRxiv : the preprint server for biology 0 41278819
2024 Genetic and epigenetic factors affecting carotid intima-media thickness in monozygotic twins. Gene 0 39547361