Affinage

AP2M1

AP-2 complex subunit mu · UniProt Q96CW1

Length
435 aa
Mass
49.7 kDa
Annotated
2026-06-09
32 papers in source corpus 19 papers cited in narrative 19 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

AP2M1 encodes the μ2 (medium, ~50 kDa) chain of the clathrin adaptor protein complex AP-2 and serves as the principal cargo-recognition module of clathrin-mediated endocytosis (PMID:3148444). Its binding domain directly engages tyrosine-based YXXΦ internalization motifs in the cytoplasmic tails of diverse transmembrane cargo, including the immune receptors CTLA-4 (PMID:9200449, PMID:9256472) and CD22 (PMID:12646615), the α1b-adrenergic receptor (PMID:18523139), the tight-junction protein claudin-2 (PMID:34964704), and the AMPA-receptor subunit GluA2 (PMID:41740904), directing these proteins into clathrin-coated vesicles. Cargo selectivity is gated by phosphorylation: for CTLA-4, phosphorylation of the YXXΦ tyrosine abolishes AP2M1 binding and instead recruits PI3K, switching the receptor between endocytic and signaling fates (PMID:9256472, PMID:9200449). AP2M1 activity is itself controlled by phosphorylation at Thr156 by NAK-family kinases (AAK1, GAK, BMP2K) and by LRRK2, which activates cargo engagement and licenses coat assembly (PMID:8257432, PMID:34315807, PMID:41982333); LRRK2 gain-of-function additionally impairs vesicle uncoating (PMID:34315807). Numerous viruses subvert this machinery by presenting their own YXXΦ motifs to AP2M1 to drive assembly, entry, and intracellular trafficking, including HCV core (PMID:22916011), PRRSV GP5/CD163 (PMID:41982333), and a broad panel of RNA viruses whose replication depends on AP2M1 (PMID:32923629). AP2M1-dependent endocytosis is required for neuronal development, supporting Vangl2-mediated dendrite morphogenesis (PMID:34626136), and a recurrent de novo p.Arg170Trp variant that blocks AP-2 conformational activation and reduces clathrin-mediated endocytosis causes developmental and epileptic encephalopathy (PMID:31104773).

Mechanistic history

Synthesis pass · year-by-year structured walk · 13 steps
  1. 1988 High

    Established the molecular identity of AP2M1 by cloning the 50 kDa medium chain of the AP-2 coat complex, defining the protein whose function would later be dissected.

    Evidence Molecular cloning and full amino-acid sequencing from rat brain cDNA

    PMID:3148444

    Open questions at the time
    • Sequence alone did not reveal the cargo-binding function
    • No structural or regulatory mechanism defined at this stage
  2. 1993 High

    Identified Thr156 as the single regulatory phosphorylation site on AP2M1, targeted by an associated kinase activity rather than autophosphorylation, establishing post-translational control of the subunit.

    Evidence In vitro phosphorylation, tryptic peptide mapping and Edman degradation

    PMID:8257432

    Open questions at the time
    • Identity of the responsible kinase(s) not established
    • Functional consequence of Thr156 phosphorylation for cargo binding not yet shown
  3. 1997 High

    Demonstrated that AP2M1 directly recognizes YXXΦ motifs in cargo, using CTLA-4, and that phosphorylation of the cargo tyrosine acts as a binary switch between AP2M1-mediated endocytosis and PI3K signaling.

    Evidence Yeast two-hybrid, Co-IP, surface expression assays, and phospho- vs non-phosphopeptide binding with Y201 mutagenesis

    PMID:9200449 PMID:9256472

    Open questions at the time
    • Generality of the YXXΦ recognition across cargo not yet established
    • Structural basis of the phospho-switch not resolved
  4. 2003 High

    Extended the cargo-recognition model to CD22, showing AP2M1-mediated internalization is a general mechanism for receptor downregulation via tyrosine motifs.

    Evidence Yeast two-hybrid, Co-IP of α-adaptin, and internalization assays with cargo mutants

    PMID:12646615

    Open questions at the time
    • Quantitative contribution of each tyrosine motif in vivo unclear
    • Did not address regulation by AP2M1 phosphorylation
  5. 2008 High

    Showed that AP2M1 binding to cargo (α1b-AR) can be necessary but insufficient for efficient internalization, positioning AP2M1 within a multi-adaptor system that includes β-arrestin.

    Evidence Co-IP, β-arrestin translocation, biotinylation, confocal imaging and RNAi

    PMID:18523139

    Open questions at the time
    • Hierarchy between AP2M1 and arrestin adaptors not generalized
    • Did not define receptor classes requiring AP2M1 alone
  6. 2012 High

    Linked AP2M1 Thr156 phosphorylation by AAK1/GAK to active cargo engagement, demonstrated for HCV core, connecting the 1993 phospho-site to functional cargo binding.

    Evidence Affinity analysis, complementation assay, Co-IP in infected cells, mutagenesis, siRNA, dominant-negative and kinase inhibition

    PMID:22916011

    Open questions at the time
    • Whether host cargo (not viral) is similarly gated by Thr156 not directly tested here
    • Structural mechanism of phospho-activation unresolved
  7. 2018 Medium

    Placed AP2M1 downstream of the cdk4–EZH2 axis in chemotherapy-induced senescence, implicating its endocytic activity in intercellular senescence signaling and escape.

    Evidence Quantitative proteomics, EZH2 siRNA/inhibition, and cell emergence assays

    PMID:29415991

    Open questions at the time
    • Direct endocytic cargo mediating senescence signals not identified
    • Mechanism inferred rather than reconstituted
  8. 2019 High

    Defined AP2M1 as a human disease gene by showing a recurrent de novo p.Arg170Trp variant impairs AP-2 conformational activation and clathrin-mediated endocytosis, causing developmental and epileptic encephalopathy.

    Evidence Exome sequencing, dynamics modeling, complementation in human cells and transferrin endocytosis in AP-2μ conditional-KO mouse astrocytes

    PMID:31104773

    Open questions at the time
    • Cell types and circuits driving epilepsy not defined
    • How reduced endocytosis produces the neurological phenotype unresolved
  9. 2020 High

    Generalized AP2M1 as a broadly exploited host factor across RNA viruses via their YXXΦ motifs, and showed pharmacological disruption of these interactions is antiviral.

    Evidence YXXΦ mutagenesis, siRNA depletion, ACA small-molecule inhibition, localization and in vitro/in vivo antiviral assays across multiple viruses

    PMID:32923629

    Open questions at the time
    • Whether ACA also impairs essential host endocytosis not fully resolved
    • Virus-specific dependencies on AP2M1 phosphorylation not dissected
  10. 2021 High

    Established LRRK2 as a direct AP2M1 kinase whose phosphorylation drives coat assembly while gain-of-function blocks uncoating, linking AP2M1 regulation to dopaminergic neurodegeneration.

    Evidence Kinase binding/phosphorylation assays in SH-SY5Y cells, LRRK2-KO and G2019S mouse tissue, and a Drosophila PD model

    PMID:34315807

    Open questions at the time
    • Whether LRRK2 and NAK kinases compete or cooperate at Thr156 unclear
    • Brain-specificity mechanism not fully explained
  11. 2021 Medium

    Expanded AP2M1's physiological roles to tight-junction remodeling (autophagy-driven CLDN2 degradation), dendrite morphogenesis (Vangl2 endocytosis), and TGF-β signaling via the C. elegans ortholog.

    Evidence Co-IP, CRISPR KO, fractionation and in vivo/ex vivo tissue (CLDN2); yeast two-hybrid and shRNA in cortical neurons (Vangl2); suppressor screen and epistasis in C. elegans (TGF-β/CAV-1)

    PMID:33561975 PMID:34626136 PMID:34964704

    Open questions at the time
    • Vangl2 and TGF-β roles rest on single-lab and ortholog evidence
    • Direct cargo relationships in mammalian neurons partially inferred
  12. 2026 High

    Connected AP2M1-driven cargo endocytosis to disease-relevant synaptic dysfunction, showing enhanced GluA2–AP2M1 interaction underlies AMPAR loss in Alzheimer models and that blocking it rescues cognition.

    Evidence Co-IP, surface biotinylation, competitive peptide (G2CT), in vivo electrophysiology and behavior in 5×FAD mice with human AD tissue validation

    PMID:41740904

    Open questions at the time
    • Whether AP2M1 Thr156 phosphorylation modulates the GluA2 interaction not tested
    • Generalizability beyond amyloid models unknown
  13. 2026 High

    Confirmed that NAK-family kinases (AAK1, GAK, BMP2K) activate AP2M1 via Thr156 to promote YXXΦ cargo engagement, demonstrated for PRRSV GP5/CD163 trafficking.

    Evidence siRNA/CRISPR and pharmacological kinase inhibition, Thr156 mutagenesis, Co-IP and viral entry/trafficking assays

    PMID:41982333

    Open questions at the time
    • Endogenous host cargo dependence on each NAK kinase not fully mapped
    • Spatial/temporal coordination with LRRK2 phosphorylation unresolved

Open questions

Synthesis pass · forward-looking unresolved questions
  • How AP2M1 loss-of-function and altered cargo selectivity translate into specific neurodevelopmental and neurodegenerative phenotypes — and how Thr156 phosphorylation by competing kinases is coordinated in vivo — remains unresolved.
  • No unified model linking endocytic deficit to circuit-level pathology
  • Kinase hierarchy controlling AP2M1 activation in different tissues undefined
  • Structural mechanism of p.Arg170Trp-induced conformational defect not solved

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0038024 cargo receptor activity 5 GO:0060090 molecular adaptor activity 5 GO:0001618 virus receptor activity 2
Localization
GO:0005886 plasma membrane 4 GO:0031410 cytoplasmic vesicle 2 GO:0005811 lipid droplet 1
Pathway
R-HSA-162582 Signal Transduction 3 R-HSA-1643685 Disease 3 R-HSA-5653656 Vesicle-mediated transport 3 R-HSA-168256 Immune System 2 R-HSA-9612973 Autophagy 1
Partners
AAK1ADRA1BCD22CLDN2CTLA4GRIA2LRRK2VANGL2
Complex memberships
AP-2 adaptor complex

Evidence

Reading pass · 19 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1988 AP50 (AP2M1) was molecularly cloned and identified as the 50 kDa medium-chain protein component of the clathrin-coated vesicle coat assembly protein complex AP-2, encoding a 435 amino acid polypeptide of 49,612 Da that is highly conserved between rat and bovine brain. Molecular cloning and amino acid sequencing from rat brain cDNA libraries DNA (Mary Ann Liebert, Inc.) High 3148444
1993 AP50 (AP2M1) is phosphorylated in vivo and in vitro at a single site, Thr-156, by an AP50 kinase activity that co-purifies with the AP complex (AP-1 and a soluble ~280 kDa protein complex); AP50 itself cannot autophosphorylate. In vitro phosphorylation, tryptic peptide mapping, automated Edman degradation, synthetic peptide substrate assay, gel filtration The Biochemical journal High 8257432
1995 The human CLAPM1 (AP2M1) gene maps to chromosome region 3q28 by chromosomal in situ hybridization. Chromosomal fluorescence in situ hybridization (FISH) of a human genomic clone Genomics Medium 8595912
1997 AP2M1 (AP50), the medium chain of AP-2, directly binds the cytoplasmic domain of CTLA-4 via the YXXΦ motif (GVYVKM, residues 199–204); mutation of Y201 abrogates binding and causes accumulation of CTLA-4 at the cell surface, demonstrating that AP2M1 mediates ligand-independent endocytosis of CTLA-4 into clathrin-coated vesicles. Yeast two-hybrid, co-immunoprecipitation, cell surface expression assay, site-directed mutagenesis (Y201 mutation) Journal of immunology High 9200449 9256472
1997 Phosphorylation of CTLA-4 Y201 abolishes its binding to AP2M1 (AP50) and instead enables binding to the p85 subunit of PI3K (and weakly to SHP-2/SHP-1), demonstrating that the phosphorylation status of the YXXΦ motif determines which downstream effector is recruited. Yeast two-hybrid, co-immunoprecipitation in 293T cells, CTLA-4 phosphopeptide vs. unphosphorylated peptide binding assays Proceedings of the National Academy of Sciences of the United States of America High 9200449 9256472
1999 The Drosophila ortholog of AP2M1 (AP50) is 86% identical to mouse and human AP2M1, is encoded by a single-copy gene at polytene chromosome position 94B1-B2, and is highly expressed in the central nervous system and midgut caecum during embryogenesis, consistent with conserved function in clathrin-mediated endocytosis in neurons. EST database identification, cDNA cloning, polytene chromosome mapping, in situ hybridization Gene Medium 10375633
2003 AP2M1 (AP50) binds the cytoplasmic domain of B cell co-receptor CD22 via tyrosine-based internalization motifs; Tyr843 constitutes the primary binding site, and either Tyr843 or Tyr863 is sufficient for mAb-mediated internalization of CD22 via the AP-2 complex. Yeast two-hybrid, co-immunoprecipitation (co-precipitation of alpha-adaptin), transfectant Jurkat cell internalization assays with wild-type and mutant CD22 Journal of immunology High 12646615
2008 AP2M1 (AP50) binds the alpha1b-adrenergic receptor (alpha1b-AR) via a YXXΦ motif in its C-tail; the alpha1a-AR does not bind AP50. Phosphorylation sites in the alpha1b-AR C-tail are required for beta-arrestin interaction (the dominant endocytic trigger), while AP50 binding alone is insufficient to drive efficient internalization. Co-immunoprecipitation, beta-arrestin translocation assays, biotinylation experiments, confocal microscopy, RNA interference Molecular pharmacology High 18523139
2012 A conserved YXXΦ motif in HCV core protein mediates direct binding to AP2M1; this interaction recruits AP2M1 to lipid droplets, promotes core trafficking away from lipid droplets toward the trans-Golgi network, and is essential for viral assembly but not RNA replication. AAK1 and GAK kinases, which phosphorylate AP2M1 at Thr156, stimulate core–AP2M1 binding and are required for HCV assembly. Microfluidics affinity analysis, protein-fragment complementation assay, co-immunoprecipitation in infected cells, YXXΦ mutagenesis, AP2M1 siRNA knockdown, dominant-negative AP2M1 overexpression, quantitative confocal immunofluorescence, pharmacological kinase inhibition PLoS pathogens High 22916011
2018 AP2M1 is identified as a downstream target of the cdk4–EZH2 axis during chemotherapy-induced senescence; AP2M1 is involved in transmission of secreted signals from senescent cells (likely via receptor endocytosis), and its upregulation by EZH2 facilitates escape from senescence in colorectal/breast cancer cells. Quantitative proteomic analysis, siRNA knockdown of EZH2, pharmacological EZH2 inhibition, cell emergence assay Cell death & disease Medium 29415991
2019 A recurrent de novo p.Arg170Trp variant in AP2M1 impairs the conformational activation of the AP-2 complex and significantly reduces clathrin-mediated endocytosis of transferrin in human cells and in astrocytes from AP-2μ conditional knockout mice, without affecting AP2M1 stability, expression, membrane recruitment, or localization. Whole-exome sequencing, protein dynamics modeling, functional complementation of p.Arg170Trp in human cells, transferrin endocytosis assay in AP-2μ conditional KO mouse astrocytes American journal of human genetics High 31104773
2020 AP2M1 is exploited by multiple viruses (influenza A, ZIKV, HIV, MERS-CoV, SARS-CoV-2, enterovirus A71) through their conserved YXXΦ motifs; AP2M1 depletion or YXXΦ mutation causes incorrect localization of viral proteins (e.g., failure of IAV nucleoprotein nuclear import, loss of ER localization of ZIKV-NS3), suppressing viral replication. The small molecule ACA disrupts AP2M1–virus interactions and inhibits viral replication in vitro and in vivo. YxxΦ mutagenesis of viral proteins, AP2M1 siRNA depletion, pharmacological inhibition (ACA compound), immunofluorescence localization, in vitro and in vivo antiviral assays across multiple virus types Science advances High 32923629
2021 AP2M1 mediates autophagy-induced clathrin-dependent endocytosis and lysosomal degradation of the tight junction protein CLDN2 (claudin-2). AP2M1 binds CLDN2 via YXXΦ motifs (residues 67–70 and 148–151), and increased AP2M1 phosphorylation upon starvation promotes CLDN2-LC3 interaction. AP2M1 knockout prevents autophagy-induced CLDN2 degradation and enhances intestinal TJ permeability. Co-immunoprecipitation, immunolocalization, membrane fractionation, pharmacological inhibition of clathrin-mediated endocytosis, site-directed mutagenesis of CLDN2 YXXΦ motifs, AP2M1 CRISPR knockout, in vitro (cell lines), in vivo (mouse colon), ex vivo (human colon) Autophagy High 34964704
2021 AP2M1 (dpy-23 in C. elegans) supports TGF-β signaling for collagen expression by limiting caveolin-1 (CAV-1) expression; loss of dpy-23/AP2M1 upregulates cav-1 in hypodermis, which increases clathrin-independent endocytosis and reduces TGF-β receptor I (TβRI) levels, thereby reducing TGF-β signaling and collagen production. C. elegans suppressor screen, RNA-seq, cav-1 RNAi knockdown, genetic epistasis (dpy-23 × lon-2 double mutant) International journal of molecular sciences Medium 33561975
2021 AP2M1 interacts with the planar cell polarity protein Vangl2 at both its N-terminus and C-terminal Prickle-binding domain; knockdown of AP2M1 in developing cortical neurons reduces dendritic branching similarly to Vangl2 knockdown, establishing AP2M1-mediated endocytosis as necessary for dendrite morphogenesis. Yeast two-hybrid screen from mouse brain lysate, pull-down assay, shRNA knockdown in cortical neurons with dendritic branching quantification Genes to cells Medium 34626136
2021 LRRK2 directly binds and phosphorylates AP2M1 (μ2 subunit of AP-2); loss of LRRK2 reduces AP2M1 phosphorylation (required for initial clathrin-coated vesicle formation), while overexpression or gain-of-function LRRK2 G2019S inhibits CCV uncoating at later stages, blocking new CCV formation cycles. LRRK2-dependent AP2M1 phosphorylation is brain-specific and mediates dopaminergic neurodegeneration in a Drosophila PD model. Kinase binding and phosphorylation assays, analysis of SH-SY5Y cells, mouse neurons and tissues (LRRK2 KO and G2019S knockin), Drosophila genetic model of PD with neurodegeneration readout Science signaling High 34315807
2025 In a Drosophila model of AP2M1-DEE, pan-neuronal RNAi knockdown of the AP-2μ ortholog causes heat-sensitive paralysis and altered class IV dendritic arborization neuron morphology; a CRISPR-engineered p.Arg170Trp fly shows a milder seizure-resistant phenotype, suggesting the epilepsy in AP2M1-DEE may arise from broader neuronal developmental defects rather than direct synaptic dysfunction. Pan-neuronal RNAi, CRISPR knock-in of p.Arg170Trp, Drosophila behavioral assays (heat-sensitive paralysis, electrically induced seizures), dendritic morphology analysis Disease models & mechanisms Medium 41017589
2026 In APP-overexpressing neurons, GluA2 (AMPAR subunit) undergoes enhanced endocytosis driven by increased interaction with AP2M1; a competitive peptide (G2CT) targeting the GluA2–AP2M1 interaction restores GluA2 membrane expression, improves synaptic function in vivo, and rescues cognitive deficits in 5×FAD mice without altering amyloid processing. Co-immunoprecipitation, surface biotinylation, competitive peptide (G2CT) treatment, in vivo electrophysiology, behavioral cognitive testing in 5×FAD mice, human AD brain tissue validation Neuropharmacology High 41740904
2026 NAK family kinases (AAK1, GAK, BMP2K) phosphorylate AP2M1 at Thr156, activating AP2M1 and promoting its interaction with the YXXΦ motif in PRRSV glycoprotein GP5 and the receptor CD163, which is critical for efficient PRRSV trafficking to early endosomes; disruption of this phosphorylation or blockade of the AP2M1–YXXΦ interaction significantly impairs PRRSV internalization. Genetic (siRNA/CRISPR) and pharmacological inhibition of AAK1/GAK/BMP2K, AP2M1 phosphorylation site mutagenesis (Thr156), co-immunoprecipitation, viral entry/trafficking assays Transboundary and emerging diseases High 41982333

Source papers

Stage 0 corpus · 32 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1997 Interaction of CTLA-4 with the clathrin-associated protein AP50 results in ligand-independent endocytosis that limits cell surface expression. Journal of immunology (Baltimore, Md. : 1950) 167 9200449
1997 Interaction of CTLA-4 with AP50, a clathrin-coated pit adaptor protein. Proceedings of the National Academy of Sciences of the United States of America 136 9256472
2012 Identification and targeting of an interaction between a tyrosine motif within hepatitis C virus core protein and AP2M1 essential for viral assembly. PLoS pathogens 129 22916011
2019 A Recurrent Missense Variant in AP2M1 Impairs Clathrin-Mediated Endocytosis and Causes Developmental and Epileptic Encephalopathy. American journal of human genetics 96 31104773
2007 Frequent overexpression of the genes FXR1, CLAPM1 and EIF4G located on amplicon 3q26-27 in squamous cell carcinoma of the lung. International journal of cancer 92 17290396
2021 AP2M1 mediates autophagy-induced CLDN2 (claudin 2) degradation through endocytosis and interaction with LC3 and reduces intestinal epithelial tight junction permeability. Autophagy 78 34964704
2020 Viruses harness YxxØ motif to interact with host AP2M1 for replication: A vulnerable broad-spectrum antiviral target. Science advances 53 32923629
2018 Regulation of senescence escape by the cdk4-EZH2-AP2M1 pathway in response to chemotherapy. Cell death & disease 51 29415991
1988 Molecular cloning and complete amino acid sequence of AP50, an assembly protein associated with clathrin-coated vesicles. DNA (Mary Ann Liebert, Inc.) 45 3148444
2008 Different internalization properties of the alpha1a- and alpha1b-adrenergic receptor subtypes: the potential role of receptor interaction with beta-arrestins and AP50. Molecular pharmacology 43 18523139
2003 The B cell coreceptor CD22 associates with AP50, a clathrin-coated pit adapter protein, via tyrosine-dependent interaction. Journal of immunology (Baltimore, Md. : 1950) 39 12646615
2021 Dysregulation of the AP2M1 phosphorylation cycle by LRRK2 impairs endocytosis and leads to dopaminergic neurodegeneration. Science signaling 33 34315807
1993 The 50 kDa protein subunit of assembly polypeptide (AP) AP-2 adaptor from clathrin-coated vesicles is phosphorylated on threonine-156 by AP-1 and a soluble AP50 kinase which co-purifies with the assembly polypeptides. The Biochemical journal 29 8257432
2022 Bioinformatics-based study reveals that AP2M1 is regulated by the circRNA-miRNA-mRNA interaction network and affects Alzheimer's disease. Frontiers in genetics 24 36468008
1991 Simple quantitative haemolytic microassay for determination of complement alternative pathway activation (AP50). Journal of immunological methods 24 2061618
1976 Characteristics of phage AP50, an RNA phage containing phospholipids. The Journal of general virology 20 822131
2020 Alantolactone inhibits cell autophagy and promotes apoptosis via AP2M1 in acute lymphoblastic leukemia. Cancer cell international 18 32943990
1999 Cloning, mapping and tissue-specific expression of Drosophila clathrin-associated protein AP50 gene. Gene 9 10375633
1995 Chromosome localization of human genes for clathrin adaptor polypeptides AP2 beta and AP50 and the clathrin-binding protein, VCP. Genomics 9 8595912
2025 AP2M1 as the potential biomarker for prediction of the response of atopic dermatitis to Dupilumab therapy: Multi-omics analysis and evidence. International journal of biological macromolecules 6 39818381
2021 AP2M1 Supports TGF-β Signals to Promote Collagen Expression by Inhibiting Caveolin Expression. International journal of molecular sciences 5 33561975
2021 Planar cell polarity protein Vangl2 and its interacting protein Ap2m1 regulate dendritic branching in cortical neurons. Genes to cells : devoted to molecular & cellular mechanisms 4 34626136
2025 AP2M1 Is a Candidate Gene for Microcephaly and Intellectual Disability in 3q27.1 Deletions. American journal of medical genetics. Part A 2 40631915
2025 AP2M1 Amplification Orchestrates Notch-Mediated Chemoresistance in Hematopoietic Stem Cells of Acute Myeloid Leukemia Patients. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2 41082341
2025 Modeling AP2M1 developmental and epileptic encephalopathy in Drosophila. Disease models & mechanisms 1 41017589
2025 Copy Number Variation and SNP Affect Egg Production in Chickens by Regulating AP2M1 Expression to Inhibit GnRH Synthesis. Animals : an open access journal from MDPI 1 41153917
2026 Mendelian randomization analysis identifies HLA-A and AP2M1 as genetic biomarkers linked to immune-endocytic crosstalk in intervertebral disc degeneration. Journal of cell communication and signaling 0 41696752
2026 Inhibiting AP2M1-mediated GluA2 endocytosis by G2CT peptide ameliorates synaptic and memory deficits in Alzheimer's Disease. Neuropharmacology 0 41740904
2026 Numb-Associated Kinases-Mediated AP2M1 Activation Facilitates Porcine Reproductive and Respiratory Syndrome Virus Entry. Transboundary and emerging diseases 0 41982333
2025 The role of AP2M1 in oncofetal characteristics: integrative in silico, in vitro, and in vivo analyses using zebrafish models. European journal of medical research 0 41327404
2025 [Clinical and genetic analysis of a child with intellectual developmental disorder and seizures associated with variant of AP2M1 gene]. Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics 0 41451492
2018 Quantitation of Regulatory Activity for the Complement Alternative PathwayUsing an Adaptation of the AP50 in vitro Assay. Bio-protocol 0 34532558

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