Affinage

ADRA1B

Alpha-1B adrenergic receptor · UniProt P35368

Length
520 aa
Mass
56.8 kDa
Annotated
2026-06-09
64 papers in source corpus 14 papers cited in narrative 14 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

ADRA1B is a Gq-coupled alpha-1B adrenergic receptor that transduces sympathetic catecholamine signaling into cell-type-specific responses across heart, airway, liver, neural, and dental tissues (PMID:35787178, PMID:39259165, PMID:40660609). In human airway smooth muscle, where it is highly expressed, ADRA1B activation by epinephrine—unmasked when beta2-AR is desensitized or blocked—drives intracellular calcium mobilization, myosin light chain phosphorylation, and cell shortening, producing bronchoconstriction that is reversed by alpha1-AR antagonism (PMID:35787178). In the heart, alpha1-AR signaling including ADRA1B is required for adaptive responses to pressure overload, protecting against fibrosis and cardiomyocyte apoptosis (PMID:16585965). In hepatocytes, ADRA1B acts as a restraint on metabolic and inflammatory dysfunction: its sex-dependent loss in female mice exacerbates diet-induced obesity, insulin resistance, and impaired gluconeogenesis (PMID:39259165), and its deletion worsens hepatic inflammation and stellate cell activation in MASLD (PMID:41087030). In human dental pulp stem cells, where it is the dominant sympathetic receptor, ADRA1B suppresses proliferation, migration, and odontoblast differentiation by reprogramming mitochondrial metabolism toward glycolysis via PGC-1alpha, an effect confirmed in vivo by sympathectomy and conditional knockout that both enhance dentine formation (PMID:37769871, PMID:40660609). ADRA1B also promotes survival in MYCN-amplified neuroblastoma, where its genetic or pharmacological inhibition sensitizes cells to retinoid-induced differentiation and controls xenograft growth (PMID:37289021). Mechanistically, ADRA1B physically associates with GPR143 through a TM2 interface that potentiates ADRA1B-mediated ERK signaling (PMID:37394637), and receptor levels are controlled both by proteasome-mediated turnover (PMID:33402011) and by epigenetic regulation of its promoter—silencing via methylation in gastric cancer and activation via histone H3 acetylation in prefrontal cortex (PMID:17242706, PMID:29247759).

Mechanistic history

Synthesis pass · year-by-year structured walk · 13 steps
  1. 2006 Medium

    Established that cardiac alpha1-AR signaling, including ADRA1B, is not dispensable but actively required for adaptive cardiac remodeling under hemodynamic stress.

    Evidence Double Adra1a/Adra1b knockout mice subjected to transverse aortic constriction with histology, echocardiography, and cardiomyocyte apoptosis assays

    PMID:16585965

    Open questions at the time
    • ADRA1A and ADRA1B knocked out together, so the individual contribution of ADRA1B cannot be isolated
    • the downstream signaling cascade protecting against apoptosis was not defined
  2. 2007 Medium

    Identified promoter methylation as an epigenetic mechanism that silences ADRA1B expression, linking receptor loss to cancer.

    Evidence Methylation-sensitive representational difference analysis, bisulfite sequencing, and RT-PCR in paired gastric tumor/normal samples

    PMID:17242706

    Open questions at the time
    • functional consequence of ADRA1B loss for gastric tumor biology not tested
    • no causal demethylation rescue experiment
  3. 2014 Medium

    Showed that ADRA1B signaling competence, not merely expression, governs hypertrophic responsiveness in stem-cell-derived cardiomyocytes.

    Evidence Expression profiling, phenylephrine stimulation, and kinase inhibitor experiments in hESC-CMs versus hiPSC-CMs

    PMID:25418732

    Open questions at the time
    • the specific inhibitory kinases blocking ADRA1B signaling in hiPSC-CMs not identified
    • relevance to in vivo adult cardiomyocyte signaling unclear
  4. 2018 Low

    Placed dopamine receptor signaling upstream of histone-acetylation-based epigenetic control of the Adra1b promoter in cortical tissue.

    Evidence ChIP-qPCR for H3 acetylation at the Adra1b promoter with D1R/D2R pharmacological blockade after in vivo modafinil or methamphetamine (consolidates 2015 and 2018 findings)

    PMID:29247759 PMID:30056065

    Open questions at the time
    • single ChIP method with no direct functional readout on ADRA1B protein or downstream signaling
    • epistasis inferred indirectly via antagonists
    • behavioral or physiological consequence not established
  5. 2021 Medium

    Quantified ADRA1B protein stability and demonstrated that proteasome-mediated turnover sets receptor half-life.

    Evidence SNAP-tag NIR-imaging cycloheximide-chase assay with bortezomib in HEK293 cells across alpha1-AR subtypes

    PMID:33402011

    Open questions at the time
    • E3 ligase and degron mediating ADRA1B turnover not identified
    • whether agonist activation alters degradation kinetics untested
  6. 2021 Medium

    Defined an ADRA1B-to-Ece1/Edn1 signaling axis driving contrast-induced kidney injury, establishing ADRA1B as a pharmacological target via terazosin.

    Evidence Kidney RNA-seq, terazosin inhibition in vivo and in HK-2 cells, immunohistochemistry, and apoptosis assays

    PMID:33711514

    Open questions at the time
    • receptor specificity of terazosin not controlled by genetic knockout
    • mechanism linking ADRA1B to endothelin gene induction not resolved
  7. 2022 High

    Demonstrated that ADRA1B mediates bronchoconstriction in human airway smooth muscle when beta2-AR braking is lost, explaining paradoxical adrenergic contraction.

    Evidence Receptor profiling, calcium imaging, MLC phosphorylation, cell shortening mechanics, and doxazosin blockade in human primary airway smooth muscle cells

    PMID:35787178

    Open questions at the time
    • in vivo airway physiological relevance not directly tested
    • the desensitization signal that unmasks ADRA1B not mapped
  8. 2023 Medium

    Revealed that ADRA1B physically couples with GPR143 through a TM2 interface to amplify ERK signaling, adding an allosteric layer of receptor regulation.

    Evidence Reciprocal co-immunoprecipitation, ERK phosphorylation assays, chimeric receptors, and TAT-TM2 disrupting peptide in HEK293T cells

    PMID:37394637

    Open questions at the time
    • interaction shown in overexpression system, not endogenous tissue
    • physiological context where GPR143-ADRA1B coupling operates unknown
  9. 2023 High

    Established ADRA1B as a pro-survival, anti-differentiation factor in MYCN-amplified neuroblastoma and a tractable combination target with retinoids.

    Evidence Genetic ADRA1B knockout, doxazosin antagonism, viability and differentiation assays, and xenograft model with 13-cis retinoic acid

    PMID:37289021

    Open questions at the time
    • downstream survival signaling opposing retinoid differentiation not defined
    • endogenous ligand driving ADRA1B in the tumor not identified
  10. 2023 Medium

    Identified ADRA1B as the dominant sympathetic receptor in dental pulp stem cells that suppresses proliferation and migration via metabolic reprogramming.

    Evidence RNA-seq, Seahorse and ATP/lactate metabolic assays, migration and cell cycle assays with ADRA1B manipulation in hDPSCs

    PMID:37769871

    Open questions at the time
    • link between Gq signaling and the glycolytic shift mechanistically incomplete
    • in vivo validation provided only by later study
  11. 2024 High

    Demonstrated a sex-specific hepatic role for ADRA1B in glucose and energy homeostasis through tissue-specific genetics.

    Evidence CRISPR-Cas9 hepatocyte-specific Adra1b knockout in female and male mice with glucose/insulin tolerance tests and metabolic phenotyping

    PMID:39259165

    Open questions at the time
    • molecular basis of sex dimorphism not resolved
    • direct hepatocyte signaling driving gluconeogenic capacity not mapped
  12. 2025 High

    Extended hepatic ADRA1B function to show it restrains inflammation and fibrosis in MASLD independent of steatosis or systemic metabolism.

    Evidence Hepatocyte-specific Adra1b knockout on MASLD diet with histology, qPCR, and cytokine protein quantification

    PMID:41087030

    Open questions at the time
    • intracellular pathway by which ADRA1B suppresses cytokine production unresolved
    • whether the effect is cell-autonomous to hepatocytes or via stellate-cell crosstalk not dissected
  13. 2025 High

    Confirmed in vivo that ADRA1B suppresses odontoblast differentiation by inhibiting PGC-1alpha-dependent mitochondrial metabolism, linking sympathetic tone to dentine formation.

    Evidence Gain/loss-of-function in hDPSCs with OCR and differentiation assays, rat sympathectomy pulp-capping model, and Adra1bflox/flox;Prx1-cre conditional knockout mice

    PMID:40660609

    Open questions at the time
    • mechanism coupling ADRA1B Gq signaling to PGC-1alpha repression not defined
    • clinical relevance to human dentine regeneration untested

Open questions

Synthesis pass · forward-looking unresolved questions
  • How a single Gq-coupled receptor produces divergent, tissue-specific outcomes—protective in heart and liver, pro-pathologic in airway, neuroblastoma, and dental pulp—remains unresolved at the level of distinct downstream effector wiring.
  • no unified map linking ADRA1B to specific second-messenger and kinase outputs per cell type
  • endogenous ligands and receptor partners in each context incompletely defined
  • structural basis of the GPR143 TM2 interaction not solved

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060089 molecular transducer activity 2 GO:0098772 molecular function regulator activity 1
Localization
GO:0005886 plasma membrane 2
Pathway
R-HSA-1430728 Metabolism 2 R-HSA-162582 Signal Transduction 2
Partners
GPR143

Evidence

Reading pass · 14 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2006 Double knockout of cardiac alpha1A (Adra1a) and alpha1B (Adra1b) adrenergic receptors in mice worsened dilated cardiomyopathy after pressure overload (transverse aortic constriction), with increased interstitial fibrosis, increased apoptosis, failed induction of fetal hypertrophic genes, and desensitized beta-ARs. Before TAC, isolated KO myocytes were more susceptible to apoptosis after oxidative and beta-AR stimulation, indicating that alpha1-AR signaling (including ADRA1B) is required for cardiac adaptive responses to pressure overload. Double-KO mouse model, transverse aortic constriction, histology, echocardiography, isolated cardiomyocyte apoptosis assays The Journal of clinical investigation Medium 16585965
2007 The ADRA1B promoter is frequently methylated in gastric cancer (70.6% of cases), and this aberrant promoter methylation is associated with reduced ADRA1B mRNA expression in 91.7% of gastric cancers with reduced expression, identifying promoter methylation as an epigenetic mechanism silencing ADRA1B in gastric cancer. Methylation-sensitive representational difference analysis (MS-RDA), bisulfite sequencing, RT-PCR British journal of cancer Medium 17242706
2014 In human embryonic stem cell-derived cardiomyocytes (hESC-CMs), ADRA1B is upregulated and its signaling is intact, mediating hypertrophic responses to the alpha1-AR agonist phenylephrine. In contrast, hiPSC-CMs show upregulation of ADRA1B but defective ADRA1B signaling due to tonic activity of inhibitory kinase pathways, resulting in failure to mount a hypertrophic response. Gene expression analysis, pharmacological stimulation, kinase inhibitor experiments in hESC-CMs and hiPSC-CMs Stem cell reports Medium 25418732
2015 ADRA1B promoter activity is regulated epigenetically: in the mouse medial prefrontal cortex, repeated modafinil treatment increased histone H3 acetylation (H3ac) enrichment at the Adra1b promoter and increased Adra1b mRNA expression, whereas repeated methamphetamine did not produce this effect. ChIP-qPCR for H3ac at Adra1b promoter, RT-PCR for mRNA, in vivo drug treatment Progress in neuro-psychopharmacology & biological psychiatry Low 29247759
2018 Acute modafinil (but not methamphetamine) increased H3ac enrichment specifically at the Adra1b promoter in the mouse medial prefrontal cortex, with D1R and D2R antagonists modulating the overall histone acetylation effects of both drugs, placing dopamine receptor signaling upstream of epigenetic regulation at Adra1b. ChIP-qPCR for histone acetylation at Adra1b promoter, pharmacological blockade of D1R/D2R, in vivo drug administration Progress in neuro-psychopharmacology & biological psychiatry Low 30056065
2021 Inhibition of Adra1b with terazosin in a mouse model of contrast-induced acute kidney injury (CI-AKI) significantly decreased serum creatinine, urinary KIM-1, HIF-1α, apoptosis, and downstream Adra1b target genes including Ece1, Edn1, and pMAPK14. In HK-2 cells, Adra1b was upregulated by contrast exposure, and its inhibition abrogated Ece1, Edn1, Fsp-1, Mmp-2, Mmp-9 expression and caspase-3/7 activity, defining an Adra1b → Ece1/Edn1 signaling axis in kidney injury. RNA-seq in mouse kidney, pharmacological inhibition with terazosin in vivo and in vitro, immunohistochemistry, functional apoptosis assays Translational research : the journal of laboratory and clinical medicine Medium 33711514
2021 SNAP-tagged ADRA1B expressed in HEK293 cells has a protein degradation half-life quantified by cycloheximide-chase assay, and degradation is primarily proteasome-mediated as shown by bortezomib treatment. The half-life for ADRA1A, ADRA1B, and ADRA1D subtypes was quantified and found to range with ADRA1D being the shortest (0.52 h). SNAP-epitope tag/NIR imaging CHX-chase assay, proteasome inhibitor bortezomib treatment, 96-well plate format SLAS discovery : advancing life sciences R & D Medium 33402011
2022 Human airway smooth muscle (HASM) cells express a high abundance of ADRA1B (the alpha1B adrenergic receptor subtype). Upon beta2-AR desensitization or pharmacological beta2-AR blockade, ADRA1B activation by epinephrine evokes intracellular calcium mobilization, myosin light chain phosphorylation, and HASM cell shortening (bronchoconstriction). This pro-contractile effect was abrogated by the alpha1-AR antagonist doxazosin mesylate. Receptor expression profiling, calcium imaging, myosin light chain phosphorylation assay, cell shortening mechanics, pharmacological blockade with doxazosin American journal of physiology. Lung cellular and molecular physiology High 35787178
2023 GPR143 (the L-DOPA receptor) functionally couples with ADRA1B through its second transmembrane (TM2) domain. Co-expression of GPR143 augments phenylephrine-induced ERK phosphorylation via ADRA1B in HEK293T cells. Immunoprecipitation confirmed a physical interaction between GPR143 and ADRA1B, and a synthetic TAT-TM2 peptide that disrupts this interaction suppressed GPR143-mediated potentiation of ADRA1B signaling. Co-immunoprecipitation, ERK phosphorylation assay, chimeric receptor analysis, TAT-fused TM2 peptide disruption experiment in HEK293T cells Biological & pharmaceutical bulletin Medium 37394637
2023 Genetic knockout of ADRA1B or its pharmacological blockade with alpha1/alpha1B antagonists selectively sensitizes MYCN-amplified neuroblastoma cells to cell viability reduction and neural differentiation induced by isotretinoin (13-cis retinoic acid). ADRA1B expression was upregulated by the synergistic compound isorhamnetin. In vivo, doxazosin combined with 13-cis retinoic acid markedly controlled tumor growth in neuroblastoma xenograft mice. Genetic KO of ADRA1B, pharmacological antagonism (doxazosin), cell viability assays, differentiation assays, xenograft mouse model Cancer research High 37289021
2023 ADRA1B is the dominant sympathetic neurotransmitter receptor expressed in human dental pulp stem cells (hDPSCs), as identified by RNA-sequencing. Sympathetic nervous system activation through ADRA1B inhibits proliferation and migration of hDPSCs via metabolic reprogramming (shift from oxidative phosphorylation to anaerobic glycolysis) and through crosstalk with serine-threonine kinase and p38 MAPK signaling pathways. RNA-sequencing for receptor identification, Seahorse metabolic assay, ATP/lactate assays, Transwell and wound healing assays, cell cycle analysis, ADRA1B manipulation in hDPSCs Journal of endodontics Medium 37769871
2024 Hepatocyte-specific deletion of Adra1b in female mice exacerbated diet-induced obesity, insulin resistance, and glucose intolerance, and was accompanied by reduced hepatic gluconeogenic capacity and reprogramming of gonadal adipose tissue with hyperleptinemia. The effect was sex-dependent: male mice with hepatic Adra1b deletion showed no significant metabolic impact, demonstrating a sex-specific role for liver ADRA1B in energy and glucose homeostasis. CRISPR-Cas9 hepatocyte-specific Adra1b knockout mouse model, glucose/insulin tolerance tests, metabolic phenotyping, gene expression analysis American journal of physiology. Endocrinology and metabolism High 39259165
2025 Hepatocyte-specific Adra1b knockout (Adra1bLKO) mice fed a MASLD-inducing diet exhibited significantly increased hepatic inflammation (elevated TNF, IL-1b, MCP-1, IL-6) and activation of hepatic stellate cells (elevated TGF-β and alpha-SMA/Acta2), without changes in steatosis, body weight, glucose tolerance, or insulin sensitivity. This identifies ADRA1B as a restraint on hepatic inflammatory and fibrotic responses in MASLD. Hepatocyte-specific Adra1b knockout mouse model, automated histological image analysis (MorphoQuant), gene expression (qPCR), cytokine protein quantification, metabolic phenotyping American journal of physiology. Gastrointestinal and liver physiology High 41087030
2025 ADRA1B activation by adrenergic signaling inhibits odontoblast differentiation of human dental pulp stem cells (hDPSCs) by suppressing mitochondrial metabolism via PGC-1α. In vivo, sympathectomy (superior cervical ganglionectomy) enhanced dentine formation in a rat pulp-capping model, and mesenchymal cell-specific Adra1b ablation (Adra1bflox/flox;Prx1-cre mice) led to increased odontoblast differentiation and tertiary dentine formation. ADRA1B overexpression/knockdown in hDPSCs, OCR measurement (Seahorse), ALP activity, alizarin red S staining, DSPP/DMP1 expression; in vivo rat sympathectomy model; conditional Adra1b KO mouse model International endodontic journal High 40660609

Source papers

Stage 0 corpus · 64 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2009 A genome-wide association study on African-ancestry populations for asthma. The Journal of allergy and clinical immunology 141 19910028
2006 Alpha1-adrenergic receptors prevent a maladaptive cardiac response to pressure overload. The Journal of clinical investigation 124 16585965
2015 Endogenous microRNAs in human microvascular endothelial cells regulate mRNAs encoded by hypertension-related genes. Hypertension (Dallas, Tex. : 1979) 93 26283043
2011 Pharmacology, biodistribution, and efficacy of GPCR-based pepducins in disease models. Methods in molecular biology (Clifton, N.J.) 53 21053136
2017 Repeated methamphetamine and modafinil induce differential cognitive effects and specific histone acetylation and DNA methylation profiles in the mouse medial prefrontal cortex. Progress in neuro-psychopharmacology & biological psychiatry 51 29247759
1999 Complete genome searches for quantitative trait loci controlling blood pressure and related traits in four segregating populations derived from Dahl hypertensive rats. Mammalian genome : official journal of the International Mammalian Genome Society 49 10051321
2010 Domperidone treatment for gastroparesis: demographic and pharmacogenetic characterization of clinical efficacy and side-effects. Digestive diseases and sciences 45 21063774
2016 Altered Expression of Genes Encoding Neurotransmitter Receptors in GnRH Neurons of Proestrous Mice. Frontiers in cellular neuroscience 39 27774052
2004 The thiazide-sensitive Na(+)-Cl(-) cotransporter gene, C1784T, and adrenergic receptor-beta3 gene, T727C, may be gene polymorphisms susceptible to the antihypertensive effect of thiazide diuretics. Hypertension research : official journal of the Japanese Society of Hypertension 39 15824464
1994 High-resolution physical mapping of human 5q31-q33 using three methods: radiation hybrid mapping, interphase fluorescence in situ hybridization, and pulsed-field gel electrophoresis. Genomics 39 7698768
2014 Aberrant α-adrenergic hypertrophic response in cardiomyocytes from human induced pluripotent cells. Stem cell reports 38 25418732
2017 Utility of miR‑133a‑3p as a diagnostic indicator for hepatocellular carcinoma: An investigation combined with GEO, TCGA, meta‑analysis and bioinformatics. Molecular medicine reports 30 29138825
2010 The effects of sex and method of blood pressure measurement on genetic associations with blood pressure in the PAMELA study. Journal of hypertension 29 20032787
2018 De novo transcriptome sequencing and analysis of male and female swimming crab (Portunus trituberculatus) reproductive systems during mating embrace (stage II). BMC genetics 27 29298661
2015 Whole-Exome Sequencing Identifies Novel Somatic Mutations in Chinese Breast Cancer Patients. Journal of molecular and genetic medicine : an international journal of biomedical research 25 26870154
2018 The effects of single-dose injections of modafinil and methamphetamine on epigenetic and functional markers in the mouse medial prefrontal cortex: potential role of dopamine receptors. Progress in neuro-psychopharmacology & biological psychiatry 23 30056065
2012 A high density linkage disequilibrium mapping in 14 noradrenergic genes: evidence of association between SLC6A2, ADRA1B and ADHD. Psychopharmacology 23 23052569
2018 A locus on chromosome 5 shows African ancestry-limited association with alloimmunization in sickle cell disease. Blood advances 19 30578281
2013 Sustained in vivo blockade of α₁-adrenergic receptors prevented some of stress-triggered effects on steroidogenic machinery in Leydig cells. American journal of physiology. Endocrinology and metabolism 18 23695211
2012 Adrenergic alpha-1 pathway is associated with hypertension among Nigerians in a pathway-focused analysis. PloS one 17 22615923
2015 The PTIP-Associated Histone Methyltransferase Complex Prevents Stress-Induced Maladaptive Cardiac Remodeling. PloS one 15 26001054
2007 Frequent reduced expression of alpha-1B-adrenergic receptor caused by aberrant promoter methylation in gastric cancers. British journal of cancer 12 17242706
2022 Characterization of lncRNA/circRNA-miRNA-mRNA network to reveal potential functional ceRNAs in the skeletal muscle of chicken. Frontiers in physiology 11 36246144
2019 Fine mapping and subphenotyping implicates ADRA1B gene variants in psoriasis susceptibility in a Chinese population. Epigenomics 11 30785334
2016 Genetic variation in the alpha1B-adrenergic receptor and vascular response. The pharmacogenomics journal 11 27089938
2011 Epistasis between neurochemical gene polymorphisms and risk for ADHD. European journal of human genetics : EJHG 11 21368917
2021 Identification of novel therapeutic targets for contrast induced acute kidney injury (CI-AKI): alpha blockers as a therapeutic strategy for CI-AKI. Translational research : the journal of laboratory and clinical medicine 10 33711514
2023 Alpha-1 Adrenergic Antagonists Sensitize Neuroblastoma to Therapeutic Differentiation. Cancer research 9 37289021
2004 Haplotype block and superblock structures of the alpha1-adrenergic receptor genes reveal echoes from the chromosomal past. Molecular genetics and genomics : MGG 9 15503142
2024 Smoking-informed methylation and expression QTLs in human brain and colocalization with smoking-associated genetic loci. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 8 38830989
2023 Chemical profiling and investigation of molecular mechanisms underlying anti-hepatocellular carcinoma activity of extracts from Polygonum perfoliatum L. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 8 37579693
2022 Epinephrine evokes shortening of human airway smooth muscle cells following β2 adrenergic receptor desensitization. American journal of physiology. Lung cellular and molecular physiology 8 35787178
2022 Synthesis of genetic association studies on autism spectrum disorders using a genetic model-free approach. Psychiatric genetics 7 35353796
2022 Theory and Applications of the (Cardio) Genomic Fabric Approach to Post-Ischemic and Hypoxia-Induced Heart Failure. Journal of personalized medicine 7 36013195
2021 Identifying Novel Psoriatic Disease Drug Targets Using a Genetics-Based Priority Index Pipeline. Journal of psoriasis and psoriatic arthritis 7 35756599
2024 Sertraline Alleviates Chronic Prostatitis by Regulating the TRPV1 Channel. Journal of inflammation research 6 38979434
2023 A novel feature selection algorithm for identifying hub genes in lung cancer. Scientific reports 6 38066059
2019 An exaggerated epinephrine-adrenergic receptor signaling impairs uterine decidualization in mice. Reproductive toxicology (Elmsford, N.Y.) 6 31520687
2025 Analysis of Transcriptome Differences Between Subcutaneous and Intramuscular Adipose Tissue of Tibetan Pigs. Genes 5 40149398
2024 Liver adrenoceptor alpha-1b plays a key role in energy and glucose homeostasis in female mice. American journal of physiology. Endocrinology and metabolism 5 39259165
2023 Integrated LC-MS/MS and network pharmacology approach for predictingactive ingredients and pharmacological mechanisms of Tribulus terrestris L. against cardiac diseases. Journal of biomolecular structure & dynamics 5 37042962
2023 Human Dental Pulp Stem Cells Are Subjected to Metabolic Reprogramming and Repressed Proliferation and Migration by the Sympathetic Nervous System via α1B-Adrenergic Receptor. Journal of endodontics 5 37769871
2015 Novel Polymorphisms of Adrenergic, Alpha-1B-, Receptor and Peroxisome Proliferator-activated Receptor Gamma, Coactivator 1 Beta Genes and Their Association with Egg Production Traits in Local Chinese Dagu Hens. Asian-Australasian journal of animal sciences 5 26954135
2023 Idiopathic Pulmonary Fibrosis Molecular Substrates Revealed by Competing Endogenous RNA Regulatory Networks. Omics : a journal of integrative biology 4 37540140
2021 Development of a Novel SNAP-Epitope Tag/Near-Infrared Imaging Assay to Quantify G Protein-Coupled Receptor Degradation in Human Cells. SLAS discovery : advancing life sciences R & D 4 33402011
1994 Genes encoding adrenergic receptors are not clustered on the long arm of human chromosome 5. Cytogenetics and cell genetics 4 8039425
2025 Mechanism of action of aloperine in the treatment of pulmonary arterial hypertension based on network pharmacology and molecular docking methods. Herz 3 40055190
2024 Investigation of risk signatures associated with anoikis in thyroid cancer through integrated transcriptome and Mendelian randomization analysis. Frontiers in endocrinology 3 39568815
2022 The Mechanism of Crocetin Targeting Cardiovascular Disease Based on Network Pharmacology Constrained by Spectral Experiments. Chemistry & biodiversity 3 36251941
2020 Mechanism underpinning effects of Shichangpu (Rhizoma Acori Tatarinowii) on attention deficit hyperactivity disorder. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 3 32227770
2008 Cloning, expression and immunolocalization of alpha1-adrenoceptor in different tissues from rhesus monkey and human male reproductive tract. Molecular human reproduction 3 18204069
2025 Maternal history of maltreatment interacts with DNA methylation patterns to predict infant temperament. Child abuse & neglect 2 40974784
2022 Influence of Receptor Polymorphisms on the Response to α-Adrenergic Receptor Blockers in Pheochromocytoma Patients. Biomedicines 2 35453646
2015 Could α1-adrenoceptors and androgen receptors be modified by sexual maturation and testosterone in the rat testicular capsule? Life sciences 2 26388559
2025 [Effect of CMTM6 on PD-L1 in Helicobacter pylori infected gastric epithelial cells]. Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences 1 40219552
2025 Genes associated with calcium signaling have promising diagnostic potential for gastric cancer. Journal of gastrointestinal oncology 1 40672086
2025 Network pharmacology and bioinformatics insight into the mechanism of GeGen-QinLian decoction in colorectal cancer and type 2 diabetes mellitus. Medicine 1 40696679
2023 L-DOPA Receptor GPR143 Functionally Couples with Adrenergic α1B Receptor at the Second Transmembrane Interface. Biological & pharmaceutical bulletin 1 37394637
2025 Sympathetic nerves inhibit dental pulp stem cell differentiation and tertiary dentine formation via α1B-adrenergic receptor. International endodontic journal 0 40660609
2025 Somatic Mutations Profiling in Genes Other than BRCA and TP53 Increasing Breast Carcinoma Risk Among Pakistani Patients. Reviews on recent clinical trials 0 40755100
2025 Loss of hepatic alpha-1b adrenoceptor exacerbates inflammation and stellate cell activation in diet-induced MASLD. American journal of physiology. Gastrointestinal and liver physiology 0 41087030
2023 Effects of Genetic Mutation Sites in ADR Genes on Modern Chickens Produced and Domesticated by Artificial Selection. Biology 0 36829448
2023 A nutrigenomics approach to study the effects of ω-3 fatty acids in laying hens under physiological stress. Frontiers in physiology 0 37560158
2023 Smoking-informed methylation and expression QTLs in human brain and colocalization with smoking-associated genetic loci. medRxiv : the preprint server for health sciences 0 37790540

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