Affinage

SDC2

Syndecan-2 · UniProt P34741

Length
201 aa
Mass
22.2 kDa
Annotated
2026-06-10
100 papers in source corpus 11 papers cited in narrative 11 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

SDC2 (syndecan-2/fibroglycan) is a transmembrane heparan sulfate proteoglycan expressed in a mesenchyme-restricted, developmentally regulated pattern that functions as a cell-surface co-receptor and scaffold to capture heparin-binding growth factors and couple them to downstream signaling (PMID:8187643, PMID:10446183). On activated macrophages it is synthesized de novo as the major surface HSPG and selectively binds FGF-2, VEGF, and HB-EGF, presenting FGF-2 in a form that transactivates FGF-receptor-bearing cells, establishing its role in growth-factor sequestration and delivery (PMID:10446183). SDC2 organizes morphogenetic signaling across systems: in zebrafish it acts cell-autonomously in Kupffer's vesicle to control left-right patterning via a Sdc2-Tbx16-Fgf2 pathway (PMID:24046323), and at developing synapses its ectodomain binds FGF22 to direct dendritic filopodial targeting and presynaptic maturation while enhancing NMDA-receptor targeting through the CASK-mLIN7-MINT1 adaptor complex (PMID:27627962). SDC2 also serves as a receptor for pleiotrophin in spermatogonial stem cells, supporting proliferation and GFRA1/HIF-1 signaling (PMID:39285301). Mechanistically it drives intracellular signaling by interacting with the PDK1 PH domain to facilitate PDK1 membrane translocation and AKT activation, and is itself stabilized post-translationally by the deubiquitinase USP14 (PMID:37496999). Microduplication of 8q22.1 encompassing SDC2 causes Leri's pleonosteosis, with SDC2 overexpression dysregulating extracellular-matrix genes and TGF-β/SMAD signaling (PMID:24442880).

Mechanistic history

Synthesis pass · year-by-year structured walk · 9 steps
  1. 1993 Medium

    Established that SDC2 (fibroglycan) marks the mesenchymal compartment during embryogenesis, distinguishing it spatially from epithelial syndecan-1 and implicating it in morphogenetic cell-cell/cell-matrix interactions.

    Evidence IHC, in situ hybridization, and Western blot of mouse embryo extracts

    PMID:8187643

    Open questions at the time
    • Localization pattern alone does not define a molecular function
    • No binding partners or signaling readouts identified
  2. 1999 Medium

    Showed SDC2 acts as a growth-factor co-receptor, answering how the proteoglycan engages signaling: it binds FGF-2, VEGF, and HB-EGF and presents FGF-2 to activate FGF-receptor-bearing cells.

    Evidence De novo synthesis analysis, growth factor binding assays, and BaF32 transactivation assay in activated macrophages

    PMID:10446183

    Open questions at the time
    • Does not resolve which structural domain (HS chains vs core protein) mediates binding
    • No downstream intracellular signaling defined
  3. 2013 Medium

    Placed SDC2 within a defined developmental signaling cascade, showing it controls left-right asymmetry cell-autonomously through a Sdc2-Tbx16-Fgf2 axis.

    Evidence Lineage-targeted morpholino knockdown with Fgf2 mRNA rescue and phenotypic readouts in zebrafish Kupffer's vesicle

    PMID:24046323

    Open questions at the time
    • Morpholino-based knockdown without genetic mutant confirmation
    • Mechanism linking Sdc2 to cilia length distinct from Fgf2 unresolved
  4. 2016 Medium

    Defined a synaptic scaffolding role: SDC2's ectodomain binds FGF22 to drive bidirectional synapse maturation and couples NMDAR targeting to the CASK-mLIN7-MINT1 adaptor complex.

    Evidence Co-IP, neuronal overexpression, live imaging of dendritic filopodia, and synaptic marker immunostaining

    PMID:27627962

    Open questions at the time
    • Co-IP interactions not validated by structural or reconstitution data
    • Stoichiometry within the adaptor complex undefined
  5. 2017 Medium

    Identified SDC2 as a functional surface marker of myogenic progenitors capable of long-term muscle regeneration, extending its role to stem/progenitor cell identity.

    Evidence PAX7 target analysis, FACS/MACS sorting, and in vivo muscle engraftment of CD54+α9β1+SDC2+ cells

    PMID:28658631

    Open questions at the time
    • Marker status does not establish a mechanistic role in myogenesis
    • Signaling downstream of SDC2 in progenitors not examined
  6. 2017 Low

    Linked SDC2 abundance to post-transcriptional control by miR-20a-5p and connected SDC2 levels to chemoresistance in osteosarcoma.

    Evidence miRNA mimic/antagomir, SDC2 siRNA knockdown and overexpression rescue, viability assays, and xenografts

    PMID:29118673

    Open questions at the time
    • Limited mechanistic depth on how SDC2 mediates drug resistance
    • Single lab, no orthogonal confirmation of the miR-20a-5p–SDC2 axis
  7. 2020 Low

    Connected SDC2 to vascular inflammatory pathology, placing it upstream of FAK/ERK signaling and under negative control by miR-9 in atherosclerosis.

    Evidence Ectopic miR-9 expression and SDC2 siRNA depletion in ACS mice with FAK/ERK Western blot and histology

    PMID:32765295

    Open questions at the time
    • Pathway placement upstream of FAK/ERK inferred indirectly
    • Single study, not independently replicated
  8. 2023 Medium

    Revealed an intracellular signaling mechanism: SDC2 binds the PDK1 PH domain to promote PDK1 membrane translocation and AKT activation, and is stabilized by the deubiquitinase USP14.

    Evidence Co-IP of SDC2-PDK1, overexpression/depletion, AKT phosphorylation Western blot, and USP14 inhibitor (IU1) treatment in gastric cancer cells

    PMID:37496999

    Open questions at the time
    • Direct vs indirect nature of SDC2-PDK1 binding not structurally resolved
    • How a transmembrane HSPG engages the cytosolic PDK1 PH domain mechanistically unclear
  9. 2024 Medium

    Established SDC2 as a pleiotrophin receptor in spermatogonial stem cells required for proliferation, PLZF/GFRA1 expression, and HIF-1 signaling.

    Evidence scRNA-seq, immunofluorescence co-localization, PTN-SDC2 immunoprecipitation, siRNA knockdown with PTN rescue, and transcriptome analysis in human SSC lines

    PMID:39285301

    Open questions at the time
    • Whether SDC2 signals alone or with a co-receptor for PTN unresolved
    • Direct interaction not validated by reciprocal or structural methods

Open questions

Synthesis pass · forward-looking unresolved questions
  • How SDC2's heparan sulfate chains versus core protein, and its transmembrane/cytoplasmic domains, mechanistically partition between extracellular growth-factor presentation and intracellular PDK1/AKT signaling across cell types remains unresolved.
  • No structural model of SDC2 in any signaling complex
  • Domain-resolution mapping of growth-factor vs adaptor binding lacking
  • Tissue-specific determinants of co-receptor partner choice unknown

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060089 molecular transducer activity 3 GO:0038024 cargo receptor activity 2 GO:0060090 molecular adaptor activity 2
Localization
GO:0005886 plasma membrane 3
Pathway
R-HSA-1266738 Developmental Biology 2 R-HSA-162582 Signal Transduction 2
Partners
FGF2FGF22HBEGFPDK1PTNUSP14VEGF

Evidence

Reading pass · 11 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1999 Activated human macrophages express a single major 48-kDa cell surface HSPG, syndecan-2 (fibroglycan), synthesized de novo upon activation. This macrophage-expressed SDC2 selectively binds FGF-2, VEGF, and HB-EGF, and can present FGF-2 in a form that transactivates FGF-receptor-bearing BaF32 cells, demonstrating SDC2's role in growth factor sequestration and delivery. De novo RNA/protein synthesis analysis, growth factor binding assays, BaF32 cell transactivation assay The Journal of biological chemistry Medium 10446183
1993 Fibroglycan (SDC2) is expressed exclusively on mesenchymal cells during mouse embryogenesis, with peak expression during morphogenetic phases and at sites of cell-cell/cell-matrix interactions (epithelial-mesenchymal interfaces, prechondrogenic condensations), in a pattern distinct from syndecan-1 (epithelial). This spatiotemporal pattern was confirmed by both immunohistochemistry and in situ hybridization. Immunohistochemistry with anti-human fibroglycan monoclonal antibody (10H4), in situ hybridization, Western blot of embryo extracts Development (Cambridge, England) Medium 8187643
2013 In zebrafish, Sdc2 (syndecan-2) regulates left-right patterning through cell-autonomous functions in Kupffer's vesicle (KV), including regulation of cell proliferation, adhesion, cilia length, and asymmetric fluid flow. Sdc2 and Tbx16 jointly regulate Fgf2 expression in KV; Fgf2 controls KV morphogenesis (but not cilia length) downstream of Sdc2, and Fgf2 mRNA rescue restores KV morphogenesis in sdc2 morphants, defining a Sdc2-Tbx16-Fgf2 pathway. Lineage-targeted morpholino knockdown, mRNA rescue, in situ hybridization, cilia length measurement, fluid flow analysis Development (Cambridge, England) Medium 24046323
2016 Postsynaptic SDC2 uses its ectodomain to interact with FGF22 and facilitate its targeting to dendritic filopodia, thereby triggering presynaptic maturation. SDC2 also enhances filopodial targeting of NMDAR via interaction with the CASK-mLIN7-MINT1 adaptor complex. Presynaptic maturation promoted by FGF22 feeds back through increased neurotransmitter release to activate NMDAR, promoting the dendritic filopodia-to-spine transition. CaMKII (activated by the NMDAR pathway) further facilitates FGF22 targeting via KIF17 regulation. Co-immunoprecipitation, transfection/overexpression in neurons, live imaging of dendritic filopodia, immunostaining of synaptic markers Scientific reports Medium 27627962
2017 SDC2 (Syndecan-2) is a surface marker on PAX7-induced human myogenic progenitors derived from pluripotent stem cells. CD54+α9β1+SDC2+ sorted cells contribute to long-term muscle regeneration in vivo, establishing SDC2 as a functional surface marker enabling isolation of myogenic progenitors. PAX7 genomic target analysis, fluorescent- and magnetic-based cell sorting (FACS/MACS), in vivo muscle engraftment assay Cell reports Medium 28658631
2023 SDC2 interacts with the PDK1-PH domain, facilitating PDK1 membrane translocation and AKT activation in gastric cancer cells. SDC2 also functions as a co-receptor for FGF2, contributing to the FGF2-AKT signaling axis. Additionally, the deubiquitinase USP14 stabilizes SDC2 protein by preventing its degradation, and the USP14 inhibitor IU1 decreases SDC2 abundance in GC cells. Co-immunoprecipitation (SDC2-PDK1 interaction), overexpression/depletion experiments, Western blot for AKT phosphorylation, USP14 inhibitor treatment, bioinformatics International journal of biological sciences Medium 37496999
2024 Pleiotrophin (PTN) secreted by Leydig cells signals to spermatogonial stem cells (SSCs) through SDC2 as a receptor. Protein immunoprecipitation confirmed PTN-SDC2 interaction in spermatogonia. SDC2 knockdown in human SSC lines impaired cell proliferation, DNA synthesis, PLZF expression, and downregulated GFRA1 and the HIF-1 signaling pathway. Exogenous PTN rescued proliferation and GFRA1 expression in SDC2 knockdown cells. Single-cell RNA sequencing analysis, immunofluorescence co-localization, protein immunoprecipitation, SDC2 siRNA knockdown, transcriptome analysis, proliferation/DNA synthesis assays Biological research Medium 39285301
2020 In atherosclerosis, SDC2 is highly expressed and miR-9 targets SDC2 to negatively regulate it. SDC2 depletion reduces aortic plaque area, collagen fiber proliferation, macrophage infiltration, and pro-inflammatory cytokines (IL-6, IL-1β, TNF-α) by suppressing the FAK/ERK signaling pathway, placing SDC2 upstream of FAK/ERK in atherosclerotic vascular pathology. Ectopic miR-9 expression in ACS mice, SDC2 siRNA depletion, Western blot for FAK/ERK pathway proteins, oil red O staining, Masson's trichrome staining, immunohistochemistry Frontiers in physiology Low 32765295
2017 miR-20a-5p targets SDC2 mRNA to suppress its expression. SDC2 mediates multi-drug resistance in osteosarcoma cells; siRNA-mediated SDC2 knockdown recapitulates the chemosensitizing effect of miR-20a-5p mimic, and SDC2 overexpression restores chemoresistance in miR-20a-5p-overexpressing cells. miRNA mimic/antagomir transfection, SDC2 siRNA knockdown, SDC2 overexpression, CCK8 cell viability assay, tumor xenograft in nude mice Cancer cell international Low 29118673
2014 Microduplication of chromosome 8q22.1 encompassing GDF6 and SDC2 causes Leri's pleonosteosis. Expression analysis of patient dermal fibroblasts shows overexpression of SDC2 dysregulates extracellular matrix genes and TGF-β pathway components, with markedly decreased inhibitory SMAD6 levels, linking SDC2 overexpression to TGF-β/SMAD signaling dysregulation. Whole-genome SNP genotyping, gene expression analysis of patient dermal fibroblasts, Western blot for SMAD6 Annals of the rheumatic diseases Low 24442880
2020 The recombinant ectodomain of syndecan-2 (HaSDC-2 from seahorse) promotes cell proliferation in a concentration-dependent manner and accelerates wound healing in scratch assays when applied exogenously. Overexpression of full-length HaSDC-2 confers significant cell survival against oxidative stressors (H2O2, HED), establishing functional roles for the SDC2 ectodomain in cell survival and proliferation. Recombinant ectodomain protein treatment, scratch wound healing assay, H2O2/HED stress survival assay, HaSDC-2 + pcDNA transfection Fish & shellfish immunology Low 31982583

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2002 HSPG modification by the secreted enzyme Notum shapes the Wingless morphogen gradient. Developmental cell 213 12015973
2013 An LRRTM4-HSPG complex mediates excitatory synapse development on dentate gyrus granule cells. Neuron 154 23911104
2013 Genome-wide identification and validation of a novel methylation biomarker, SDC2, for blood-based detection of colorectal cancer. The Journal of molecular diagnostics : JMD 145 23747112
1993 Spatial and temporal changes in the expression of fibroglycan (syndecan-2) during mouse embryonic development. Development (Cambridge, England) 132 8187643
2004 Axon sorting in the optic tract requires HSPG synthesis by ext2 (dackel) and extl3 (boxer). Neuron 131 15603738
2009 HTLV-1 uses HSPG and neuropilin-1 for entry by molecular mimicry of VEGF165. Blood 125 19270265
2005 HSPG synthesis by zebrafish Ext2 and Extl3 is required for Fgf10 signalling during limb development. Development (Cambridge, England) 115 16221725
1994 Lactoferrin binding to heparan sulfate proteoglycans and the LDL receptor-related protein. Further evidence supporting the importance of direct binding of remnant lipoproteins to HSPG. Arteriosclerosis and thrombosis : a journal of vascular biology 112 7526899
2019 Early detection of colorectal cancer based on presence of methylated syndecan-2 (SDC2) in stool DNA. Clinical epigenetics 105 30876480
1999 Inducible expression of the cell surface heparan sulfate proteoglycan syndecan-2 (fibroglycan) on human activated macrophages can regulate fibroblast growth factor action. The Journal of biological chemistry 104 10446183
2017 Colorectal adenoma and cancer detection based on altered methylation pattern of SFRP1, SFRP2, SDC2, and PRIMA1 in plasma samples. Epigenetics 96 28753106
2007 TACI regulates IgA production by APRIL in collaboration with HSPG. Blood 93 17119122
2017 Feasibility of quantifying SDC2 methylation in stool DNA for early detection of colorectal cancer. Clinical epigenetics 91 29225717
1997 Autism and multiple exostoses associated with an X;8 translocation occurring within the GRPR gene and 3' to the SDC2 gene. Human molecular genetics 88 9259269
1989 The Caenorhabditis elegans gene sdc-2 controls sex determination and dosage compensation in XX animals. Genetics 78 2759421
2017 PAX7 Targets, CD54, Integrin α9β1, and SDC2, Allow Isolation of Human ESC/iPSC-Derived Myogenic Progenitors. Cell reports 68 28658631
2020 Robust performance of a novel stool DNA test of methylated SDC2 for colorectal cancer detection: a multicenter clinical study. Clinical epigenetics 67 33126908
2004 Glypican-1 as an Abeta binding HSPG in the human brain: its localization in DIG domains and possible roles in the pathogenesis of Alzheimer's disease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 59 15084524
2018 An Input-Specific Orphan Receptor GPR158-HSPG Interaction Organizes Hippocampal Mossy Fiber-CA3 Synapses. Neuron 58 30290982
2012 Evaluating the performance of fibronectin 1 (FN1), integrin α4β1 (ITGA4), syndecan-2 (SDC2), and glycoprotein CD44 as the potential biomarkers of oral squamous cell carcinoma (OSCC). Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 58 23116545
2009 The heparan sulfate proteoglycan (HSPG) glypican-3 mediates commitment of MC3T3-E1 cells toward osteogenesis. Journal of cellular physiology 56 19479939
2020 Aberrant DNA Methylation of SEPT9 and SDC2 in Stool Specimens as an Integrated Biomarker for Colorectal Cancer Early Detection. Frontiers in genetics 51 32625237
2007 Adenovirus 5 fibers mutated at the putative HSPG-binding site show restricted retargeting with targeting peptides in the HI loop. Molecular therapy : the journal of the American Society of Gene Therapy 50 17245351
1988 Effect of puromycin aminonucleoside on HSPG core protein content of glomerular epithelial cells. The American journal of physiology 40 2972214
2008 A translational block to HSPG synthesis permits BMP signaling in the early Drosophila embryo. Development (Cambridge, England) 39 18256192
2021 SDC2 and TFPI2 Methylation in Stool Samples as an Integrated Biomarker for Early Detection of Colorectal Cancer. Cancer management and research 38 33958894
2016 Mobility of "HSPG-bound" LPL explains how LPL is able to reach GPIHBP1 on capillaries. Journal of lipid research 37 27811232
2014 Osteoactivin promotes osteoblast adhesion through HSPG and αvβ1 integrin. Journal of cellular biochemistry 34 24415158
2010 HSPG-binding peptide corresponding to the exon 6a-encoded domain of VEGF inhibits tumor growth by blocking angiogenesis in murine model. PloS one 33 20376344
2020 Umbilical cord-derived CD362+ mesenchymal stromal cells for E. coli pneumonia: impact of dose regimen, passage, cryopreservation, and antibiotic therapy. Stem cell research & therapy 32 32169108
2020 Circular RNA circNFATC3 acts as a miR-9-5p sponge to promote cervical cancer development by upregulating SDC2. Cellular oncology (Dordrecht, Netherlands) 29 32902825
2017 MiR-20a-5p represses the multi-drug resistance of osteosarcoma by targeting the SDC2 gene. Cancer cell international 29 29118673
2017 Control of Cell Shape, Neurite Outgrowth, and Migration by a Nogo-A/HSPG Interaction. Developmental cell 26 28943240
2017 Neuronal activity drives FMRP- and HSPG-dependent matrix metalloproteinase function required for rapid synaptogenesis. Science signaling 24 29114039
2021 Stool DNA test targeting methylated syndecan-2 (SDC2) as a noninvasive screening method for colorectal cancer. Bioscience reports 23 33393623
2021 The HSPG syndecan is a core organizer of cholinergic synapses. The Journal of cell biology 22 34213535
2016 Postsynaptic SDC2 induces transsynaptic signaling via FGF22 for bidirectional synaptic formation. Scientific reports 22 27627962
2013 A network of HSPG core proteins and HS modifying enzymes regulates netrin-dependent guidance of D-type motor neurons in Caenorhabditis elegans. PloS one 22 24066155
2003 Co-inheritance of specific genotypes of HSPG and ApoE gene increases risk of type 2 diabetic nephropathy. Molecular and cellular biochemistry 22 14674716
2022 Diagnostic accuracy of DNA-based SDC2 methylation test in colorectal cancer screening: a meta-analysis. BMC gastroenterology 21 35754025
2021 Methylated SFRP2 and SDC2 in stool specimens for Colorectal Cancer early detection: A cost-effective strategy for Chinese population. Journal of Cancer 20 33854626
2020 microRNA-9 Inhibits Vulnerable Plaque Formation and Vascular Remodeling via Suppression of the SDC2-Dependent FAK/ERK Signaling Pathway in Mice With Atherosclerosis. Frontiers in physiology 19 32765295
2014 Leri's pleonosteosis, a congenital rheumatic disease, results from microduplication at 8q22.1 encompassing GDF6 and SDC2 and provides insight into systemic sclerosis pathogenesis. Annals of the rheumatic diseases 19 24442880
2023 SDC2 Stabilization by USP14 Promotes Gastric Cancer Progression through Co-option of PDK1. International journal of biological sciences 18 37496999
2021 Colorectal cancer screening using a stool DNA-based SDC2 methylation test: a multicenter, prospective trial. BMC gastroenterology 18 33858326
2008 Insight into the role of HSPG in the cellular uptake of apolipoprotein E-derived peptide micelles and liposomes. Biochimica et biophysica acta 18 18930020
2022 A novel method for early detection of colorectal cancer based on detection of methylation of two fragments of syndecan-2 (SDC2) in stool DNA. BMC gastroenterology 16 35436855
2013 Sdc2 and Tbx16 regulate Fgf2-dependent epithelial cell morphogenesis in the ciliated organ of asymmetry. Development (Cambridge, England) 16 24046323
2010 The adenovirus type 3 dodecahedron's RGD loop comprises an HSPG binding site that influences integrin binding. Journal of biomedicine & biotechnology 16 20224646
2019 Fluoride regulates the expression of extracellular matrix HSPG and related signaling pathways FGFR3 and Ihh/PTHrP feedback loop during endochondral ossification. Environmental toxicology and pharmacology 15 31731208
2007 HSPG modulation of BMP signaling in fibrodysplasia ossificans progressiva cells. Journal of cellular biochemistry 15 17516498
2020 Umbilical Cord-Derived CD362+ Mesenchymal Stromal Cells Attenuate Polymicrobial Sepsis Induced by Caecal Ligation and Puncture. International journal of molecular sciences 14 33158246
2023 Combined detection of SDC2/ADHFE1/PPP2R5C methylation in stool DNA for colorectal cancer screening. Journal of cancer research and clinical oncology 13 37270460
2021 Effects of Altering HSPG Binding and Capsid Hydrophilicity on Retinal Transduction by AAV. Journal of virology 13 33658343
2019 The HSPG Glypican Regulates Experience-Dependent Synaptic and Behavioral Plasticity by Modulating the Non-Canonical BMP Pathway. Cell reports 13 31533037
2018 Regulation of eosinophil recruitment and allergic airway inflammation by heparan sulfate proteoglycan (HSPG) modifying enzymes. Experimental lung research 13 29621420
2014 Ectopic expression screen identifies genes affecting Drosophila mesoderm development including the HSPG Trol. G3 (Bethesda, Md.) 13 25538103
2002 Heparan sulfate (HS)/heparan sulfate proteoglycan (HSPG) and bikunin are up-regulated during calcium oxalate nephrolithiasis in rat kidney. The Kurume medical journal 13 12471724
1997 Time-dependent increases in syndecan-1 and fibroglycan messenger RNA expression in the infarct zone after experimentally induced myocardial infarction in rats. Coronary artery disease 13 9237025
1990 In situ hybridization to human chromosome 1 of a cDNA probe for the gene encoding the basement membrane heparan sulfate proteoglycan (HSPG). Cytogenetics and cell genetics 13 2249476
2022 Evaluation of combined detection of multigene mutation and SDC2/SFRP2 methylation in stool specimens for colorectal cancer early diagnosis. International journal of colorectal disease 12 35499710
2021 Identification of two methylated fragments of an SDC2 CpG island using a sliding window technique for early detection of colorectal cancer. FEBS open bio 12 33955718
2022 The methylation of SDC2 and TFPI2 defined three methylator phenotypes of colorectal cancer. BMC gastroenterology 11 35227195
2016 Desulfation of cell surface HSPG is an effective strategy for the treatment of gallbladder carcinoma. Cancer letters 11 27502167
2006 Real time monitoring of the effects of Heparan Sulfate Proteoglycan (HSPG) and surface charge on the cell adhesion process using thickness shear mode (TSM) sensor. Biosensors & bioelectronics 11 17175157
2024 DNA methylation analysis of the SDC2, SEPT9 and VIM genes in fecal DNA for colorectal cancer diagnosis. BMC cancer 10 39350171
2008 Complementary expression of HSPG 6-O-endosulfatases and 6-O-sulfotransferase in the hindbrain of Xenopus laevis. Gene expression patterns : GEP 10 19059363
2022 External quality assessment for detection of methylated Syndecan 2 (SDC2) in China. Clinical chemistry and laboratory medicine 8 35942951
2018 Heparan sulfate proteoglycan (HSPG) can take part in cell division: inside and outside. Cellular and molecular life sciences : CMLS 8 30465083
2009 Reduced APRIL expression induces cellular senescence via a HSPG-dependent pathway. Pathology oncology research : POR 8 19466596
2022 Downregulation of lncRNA SNHG16 inhibits vascular smooth muscle cell proliferation and migration in cerebral atherosclerosis by targeting the miR-30c-5p/SDC2 axis. Heart and vessels 7 35320391
2022 Analysis of SDC2 gene promoter methylation in whole blood for noninvasive early detection of colorectal cancer. Journal of cancer research and therapeutics 7 36510988
2014 Association of the SNP rs2623047 in the HSPG modification enzyme SULF1 with an Australian Caucasian breast cancer cohort. Gene 7 24911625
2024 PTN from Leydig cells activates SDC2 and modulates human spermatogonial stem cell proliferation and survival via GFRA1. Biological research 6 39285301
2010 Glial cells modulate heparan sulfate proteoglycan (HSPG) expression by neuronal precursors during early postnatal cerebellar development. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 6 20638466
2006 Femtosecond dynamics of proteoheparan sulfate (HS-PG) after UV excitation--a readout for arteriosclerotic nanoplaque formation? Biochemical and biophysical research communications 6 16707112
2024 Evaluating the clinical performance of SDC2/NDRG4 methylation for colorectal cancer detection. Epigenomics 5 38226561
2024 Dystroglycan-HSPG interactions provide synaptic plasticity and specificity. Glycobiology 5 39223703
2024 A Stool DNA-Based SDC2 Methylation Test for the Early Detection of Colorectal Cancer in an Asymptomatic, High-Risk Population: A Multicenter Prospective Randomized Trial. The American journal of gastroenterology 5 39292188
2023 Value of Methylation Status of RPRM, SDC2, and TCF4 Genes in Plasma for Gastric Adenocarcinoma Screening. International journal of general medicine 5 36855658
2023 [Methylated SDC2 testing in stool DNA for early screening of colorectal cancer in Shipai Town, Dongguan City]. Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery 5 37072315
2008 A computational model of FGF-2 binding and HSPG regulation under flow. IEEE transactions on bio-medical engineering 5 19272950
2023 Diagnostic value of human fecal SDC2 gene in colorectal cancer. American journal of translational research 4 37193183
2022 SEPTIN9-SDC2-VIM methylation signature as a biomarker for the early diagnosis of colorectal cancer. American journal of cancer research 4 35968354
2025 Ephrin-B1 regulates cell surface residency of heparan sulfate proteoglycans (HSPGs) and complexes with the HSPG CD44V3-10 and fibroblast growth factor receptors. Glycobiology 3 40294072
2024 Interlaboratory consistency of SDC2 promoter methylation detection in colorectal cancer using the post-optimized materials. iScience 3 39569371
2022 Methylation of CpG island promoters at ZNF625, LONRF2, SDC2 and WDR17 in a patient with numerous non-granular type laterally spreading tumors and colorectal cancer: A case report. Oncology letters 3 36478906
2021 Association of Nucleotide Variants of GRHL3, IRF6, NAT2, SDC2, BCL3, and PVRL1 Genes with Nonsyndromic Cleft Lip With/Without Cleft Palate in Multigenerational Families: A Retrospective Study. Contemporary clinical dentistry 3 34220153
2020 Molecular insights and immune responses of big belly seahorse syndecan-2 (CD362): Involvement of ectodomain in regulating cell survival, proliferation, and wound healing. Fish & shellfish immunology 3 31982583
2011 Inhibition of human tumor xenograft growth in nude mice by a novel monoclonal anti-HSPG isolated from human liver. Anticancer research 3 22199263
2025 SDC2 and FN as cargo proteins in circulating extracellular vesicles in obese breast cancer patients with lymph node metastasis. Scientific reports 2 40940401
2024 Cancer-associated point mutations within the extracellular domain of PTPRD affect protein stability and HSPG interaction. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2 38593345
2024 Fecal methylated syndecan-2 (SDC2) testing for early screening of colorectal cancerous and precancerous lesions: A real-world retrospective study in China. Cancer pathogenesis and therapy 2 39872370
2023 Development of a new heparan sulfate proteoglycan (HSPG) chromolith LC column to study the pH dependence binding of peptide vaccines to HSPG and role of human serum albumin on its binding. Analytical methods : advancing methods and applications 2 36810922
2023 Value of faecal exfoliated cells in colorectal tumour screening using SDC2 methylation test. Annals of medicine 2 37783044
2022 Integrated computational approach towards identification of HSPG and ACE2 mimicking moieties for SARS-CoV-2 inhibition. Journal of molecular liquids 2 36276265
2022 [Application study of stool-based methylated SDC2 test in the screening of colorectal neoplasms for physical examination population]. Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine] 2 36536564
2025 Early Diagnosis of Colorectal Cancer via Plasma-Derived SDC2, KCNQ5, and IKZF1 Methylation Levels. Clinical laboratory 1 40066557
2025 An Automated Multi-Sample Digital LAMP Platform for Quantitative Detection of SDC2 Methylation in Colorectal Cancer. Analytical chemistry 1 40990394
2010 [Effects of qufengtongluo recipe on expressions of HSPG mRNA and protein in adriamycin-induced nephropathy rats]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 1 20506637

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