Affinage

Showing RPL10 — UL16 is a alias.

RPL10

Large ribosomal subunit protein uL16 · UniProt P27635

Length
214 aa
Mass
24.6 kDa
Annotated
2026-06-10
100 papers in source corpus 27 papers cited in narrative 27 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

RPL10 (QM/uL16) is an essential protein of the 60S large ribosomal subunit that couples late cytoplasmic ribosome maturation to the mechanics of translation elongation (PMID:18824477, PMID:24214990). It assembles onto the 60S subunit at a late cytoplasmic step rather than in the nucleolus (PMID:9443083), where it is required for release of the nuclear export adapter Nmd3 from the ribosome; mutations in its central loop (residues ~102–112) impair Nmd3 release, and the loop also mediates recruitment of the maturation factor Sdo1, linking maturation to the subunit's rotational state (PMID:17761675, PMID:24214990). Within the mature ribosome, an internal loop of RPL10 acts as a central controller of intersubunit rotation that propagates allosteric information across both subunits, while its N-terminal hook inserts into 25S/23S rRNA helix 89 to govern tRNA movement through the large subunit and translational fidelity (PMID:18824477, PMID:24214990); the bacterial ortholog uL16 participates in A-tRNA discrimination at the A-site entrance corridor (PMID:27791159). In bacteria, the L10 ortholog autoregulates its own operon by forming an L10(L12)4 complex that binds kink-turn motifs shared between its mRNA leader and rRNA, repressing expression by translational or transcription-attenuation mechanisms, and free L10 is rapidly degraded unless stabilized by L12 (PMID:6765237, PMID:18247578, PMID:26101249, PMID:2403546). Beyond the ribosome, RPL10 binds the SH3 domain of c-Yes and suppresses its kinase activity (PMID:12138090), localizes to mitochondria where it modulates Complex I activity and ROS levels (PMID:30172100), and undergoes ufmylation that drives cancer cell proliferation and stemness via KLF4 (PMID:37280198). Recurrent somatic RPL10 mutations, most notably R98S, occur in ~10% of pediatric T-ALL and cause ribosome biogenesis defects (PMID:23263491); mechanistically R98S traps Nmd3 in the P site by blocking Sdo1-stimulated Efl1 GTPase activity (PMID:28715419), impairs programmed ribosomal frameshifting at JAK-STAT genes to hyper-activate that pathway (PMID:28744013), and shifts cells toward IRES-dependent BCL-2 translation under mitochondrial ROS stress, conferring Venetoclax sensitivity (PMID:29930300). RPL10 missense variants also cause X-linked microcephaly and intellectual disability with associated translational defects (PMID:25316788, PMID:26290468).

Mechanistic history

Synthesis pass · year-by-year structured walk · 17 steps
  1. 1980 High

    Established that the L10 ribosomal protein controls its own expression, defining ribosomal protein autoregulation at the translational level.

    Evidence DNA-dependent cell-free in vitro translation with purified E. coli L10

    PMID:6994102

    Open questions at the time
    • Did not identify the RNA element bound
    • Bacterial system; eukaryotic relevance untested
  2. 1982 High

    Identified the molecular basis of autoregulation by showing the L10-L12 complex binds the operon mRNA leader and that rRNA competes for binding, providing a feedback link between ribosome assembly and protein synthesis.

    Evidence mRNA binding assays, leader RNA deletion/point mutations, rRNA competition

    PMID:6765237

    Open questions at the time
    • Structural basis of dual mRNA/rRNA recognition not resolved
    • Bacterial operon context
  3. 1990 Medium

    Resolved how L10/L12 stoichiometry is balanced, showing free L10 is degraded unless stabilized by complex formation with L7/L12.

    Evidence rplL ribosome-binding-site genetics, overproduction, pulse-chase stability analysis in E. coli

    PMID:2403546

    Open questions at the time
    • Protease responsible not identified
    • Bacterial system
  4. 1996 Medium

    Connected mammalian RPL10 to candidate extraribosomal roles by identifying it as the Jun-binding protein/QM tumor-suppressor homolog.

    Evidence cDNA and N-terminal protein sequencing, Southern blot

    PMID:8780716

    Open questions at the time
    • Functional consequence of Jun interaction not tested here
  5. 1998 Medium

    Localized 60S assembly of RPL10 to the cytoplasm, establishing that it acts at a late, post-nucleolar maturation step.

    Evidence Immunofluorescence co-localization with a core 60S protein in human cells

    PMID:9443083

    Open questions at the time
    • Single localization method
    • Mechanism of assembly not defined
  6. 2002 Medium

    Provided direct biochemical evidence for an extraribosomal signaling role by showing RPL10/QM binds and suppresses c-Yes kinase.

    Evidence SH3 pull-down/co-IP, in vitro kinase and autophosphorylation assays, immunofluorescence

    PMID:12138090

    Open questions at the time
    • Physiological context of c-Yes suppression unclear
    • Single lab
  7. 2007 High

    Mapped a central loop of Rpl10 as required for release of the export adapter Nmd3, linking RPL10 to controlled 60S maturation and nuclear export.

    Evidence Systematic mutagenesis, Nmd3 release and localization assays in yeast

    PMID:17761675

    Open questions at the time
    • Structural state of the loop during release not captured
    • GTPase coupling not yet defined
  8. 2008 High

    Defined how RPL10 transduces conformational signals, showing the N-terminal hook in rRNA helix 89 controls tRNA movement, elongation factor binding, and fidelity.

    Evidence Yeast mutagenesis, rRNA chemical probing, drug-sensitivity and fidelity assays

    PMID:18824477

    Open questions at the time
    • Atomic-resolution dynamics of the hook during elongation not resolved
  9. 2008 High

    Showed the L10(L12)4 complex uses shared kink-turn motifs to bind both mRNA and rRNA, unifying the autoregulatory and assembly functions, with L11 enhancing rRNA binding.

    Evidence Fluorescence binding/affinity assays and kink-turn mutagenesis with bacterial L10(L12)4

    PMID:18247578

    Open questions at the time
    • Bacterial system
    • Eukaryotic equivalent of motif-based regulation untested
  10. 2013 High

    Identified the RPL10 internal loop as a central controller of ribosomal intersubunit rotation that allosterically links all functional centers and couples rotation to Sdo1-dependent maturation.

    Evidence rRNA chemical probing, frameshifting/fidelity assays, suppressor genetics, EF-binding assays in yeast

    PMID:24214990

    Open questions at the time
    • Direct structural snapshots of loop-driven rotation lacking
  11. 2012 Medium

    Linked RPL10 to cancer by discovering recurrent somatic mutations (R98S) in pediatric T-ALL associated with ribosome biogenesis defects.

    Evidence Exome sequencing of T-ALL patients with yeast and lymphoid cell functional validation

    PMID:23263491

    Open questions at the time
    • Molecular mechanism of R98S not yet defined at this stage
  12. 2017 High

    Defined the molecular defect of R98S, showing it traps Nmd3 in the P site by blocking Sdo1-stimulated Efl1 GTPase activity, with suppressors validating the mechanism.

    Evidence In vitro reconstitution with purified components, GTPase and Nmd3 release assays, yeast suppressor genetics

    PMID:28715419

    Open questions at the time
    • How trapped Nmd3 translates to oncogenic ribosome function not addressed here
  13. 2017 High

    Connected R98S to oncogenic signaling, showing impaired ribosomal frameshifting at JAK-STAT genes reduces JAK1 degradation and hyper-activates JAK-STAT.

    Evidence Proteome screen, transgenic mouse and xenograft models, frameshift reporters, proteasome assays

    PMID:28744013

    Open questions at the time
    • Generality of frameshift defect across transcripts not fully mapped
  14. 2018 High

    Established a metabolic/survival axis for R98S, linking ROS accumulation and mitochondrial dysfunction to IRES-driven BCL-2 translation and Venetoclax sensitivity.

    Evidence ROS/mitochondrial/ATP assays, IRES reporters, BCL-2 quantification, xenograft Venetoclax treatment

    PMID:29930300

    Open questions at the time
    • Mechanism coupling ribosome defect to IRES selectivity not fully resolved
  15. 2018 Medium

    Identified a mitochondrial role for RPL10 in regulating Complex I activity and ROS, while excluding a transcription-factor function.

    Evidence ChIP-seq, transcriptomics, Complex I activity and ROS assays in pancreatic cancer cells

    PMID:30172100

    Open questions at the time
    • How a ribosomal protein localizes to and acts in mitochondria unresolved
    • Single lab
  16. 2014 High

    Demonstrated RPL10 dosage and loss-of-function cause neurodevelopmental disease, with K78E reducing bulk translation and increasing brain apoptosis.

    Evidence Zebrafish knockdown and in vivo complementation, translation and apoptosis assays

    PMID:25316788

    Open questions at the time
    • Tissue specificity of translational vulnerability not explained
  17. 2023 Medium

    Identified ufmylation of RPL10 as a post-translational modification driving cancer cell proliferation and stemness via KLF4 upregulation.

    Evidence Mass spectrometry site mapping, site mutagenesis, proliferation/stemness assays, KLF4 analysis in tissues

    PMID:37280198

    Open questions at the time
    • UFM1 ligase machinery and mechanistic link to KLF4 not defined
    • Single lab

Open questions

Synthesis pass · forward-looking unresolved questions
  • How RPL10's ribosomal, mitochondrial, and signaling activities are integrated, and how its ufmylation and extraribosomal interactions are regulated in human cells, remains open.
  • No structural model of human RPL10 during Nmd3 release
  • Mechanism of mitochondrial targeting unknown
  • Regulation of ufmylation in vivo undefined

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0003723 RNA binding 3 GO:0005198 structural molecule activity 3 GO:0098772 molecular function regulator activity 3
Localization
GO:0005840 ribosome 3 GO:0005739 mitochondrion 1 GO:0005829 cytosol 1
Pathway
R-HSA-1643685 Disease 3 R-HSA-8953854 Metabolism of RNA 2
Partners
EFL1NMD3RPL11RPL12RPS6SBDSUFM1YES1
Complex memberships
60S large ribosomal subunitL10(L12)4 complex

Evidence

Reading pass · 27 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1982 The ribosomal protein L10-L12 complex binds specifically to the leader sequence of the L10 operon mRNA, preventing translation of L10 and L12 proteins. rRNA prevents this binding, and extended sequence homologies between 23S rRNA and the L10 leader RNA were identified, suggesting the L10-L12 complex can be sequestered into assembling 50S subunits to relieve translational repression. mRNA binding assay, deletion/point mutation analysis of leader RNA, rRNA competition assay The EMBO journal High 6765237
1980 E. coli ribosomal protein L10 autoregulates its own translation in vitro: addition of exogenous L10 inhibits L10 synthesis but not L12, beta/beta'-RNA polymerase subunit, or EF-Tu synthesis. Inhibition occurs at the level of translation, not mRNA degradation. DNA-dependent cell-free protein synthesis (in vitro translation assay) with purified L10 Proceedings of the National Academy of Sciences of the United States of America High 6994102
1979 Chemical modification of arginine residues in E. coli ribosomal protein L10 inhibits its binding to ribosomes and 23S rRNA but does not affect its ability to bind four molecules of L7/L12. This suggests L10 uses separate domains for rRNA/ribosome binding versus L7/L12 interaction, and its role in promoting L7/L12 ribosome association is mediated through simultaneous binding to both 23S rRNA and L7/L12. Chemical modification (arginine-specific reagents) of L10 followed by binding assays with ribosomes, 23S rRNA, and L7/L12 Nucleic acids research Medium 379826
1989 Structural and sequence analysis revealed that eukaryotic and archaebacterial L10 proteins contain approximately three-fourths of an L12 protein sequence fused to their C-terminus, with a repeated 26-amino acid module present in two copies in eukaryotes that may mediate L12 dimerization and L10-L12 complex formation. Comparative sequence analysis of cloned L10 genes from Halobacterium, Sulfolobus, and Saccharomyces cerevisiae Canadian journal of microbiology Low 2497941
1990 E. coli ribosomal protein L10 is rapidly proteolytically degraded when synthesized in excess of L7/L12. L7/L12 stabilizes L10 by forming a complex with it; free L10 (not complexed with L7/L12) is subject to rapid proteolytic decay, contributing to balanced stoichiometric expression of both proteins. Genetic manipulation of rplL ribosome-binding site, overproduction in trans, pulse-chase analysis of protein stability Journal of bacteriology Medium 2403546
1996 Rat ribosomal protein L10 was found to be the mammalian homolog of the chicken Jun-binding protein (Jif-1) and nearly identical to a putative Wilms' tumor suppressor (QM), indicating conservation of potential extraribosomal functions. The protein has 213 amino acids (N-terminal Met removed post-translationally) with a molecular weight of 24,456 Da. cDNA sequencing, N-terminal amino acid sequencing, Southern blot hybridization Biochemical and biophysical research communications Medium 8780716
1998 The human QM protein (RPL10) assembles onto the 60S ribosomal subunit in the cytoplasm, not in the nucleolus. Immunofluorescence co-localization showed QM co-localizes with the large P-antigen (60S core ribosomal protein) only in the cytoplasm at the rough endoplasmic reticulum, consistent with a role in a late step of 60S subunit assembly. Indirect immunofluorescence co-localization with core 60S ribosomal protein (large P-antigen) in human cells Journal of cellular biochemistry Medium 9443083
2002 The QM protein (RPL10) interacts with the SH3 domain of the proto-oncogene c-Yes kinase through two distinct regions of QM (neither containing canonical SH3 binding motifs), reduces c-Yes kinase activity by ~70%, and inhibits c-Yes autophosphorylation. QM overexpression also increases c-Yes protein and mRNA levels. Co-localization in tumor cell lines was demonstrated by immunofluorescence. SH3 domain pull-down/co-IP, in vitro kinase activity assay, autophosphorylation assay, immunofluorescence co-localization The Journal of biological chemistry Medium 12138090
2003 E. histolytica L10 (EhL10, homologous to human QM/RPL10) is part of the ribosomal complex, localizes primarily to the nucleus of trophozoites, and overexpression reduces cellular growth by 60%. DNA mobility-shift assays showed EhL10 can destabilize the AP-1 (activating protein 1) complex by binding specifically to the c-Jun-like protein, suggesting an extraribosomal function in suppressing c-Jun-dependent gene transcription. Western blot fractionation, immunofluorescence, overexpression growth assay, DNA mobility-shift (EMSA) assay Molecular and biochemical parasitology Medium 12672524
2004 In yeast, rpL10/Grc5p functionally interacts with the nuclear export factor Nmd3p to modulate the cellular polysome complement, and with small subunit protein rpS6 in 40S/60S subunit joining and differential protein expression. Genetic and biochemical analysis of polysome profiles, subunit joining assays, functional interaction studies in S. cerevisiae FEMS yeast research Medium 15556089
2006 Two missense mutations (L206M and H213Q) in human RPL10 identified in autism patients confer hypomorphism with respect to translational regulation while preserving basic translation function, as assessed using yeast as a model system with aberrant ribosomal profiles. Yeast complementation/ribosomal profile analysis with patient-derived RPL10 mutants Molecular psychiatry Medium 16940977
2006 Heterozygosity for rpl10Δ in yeast reduces the translating ribosome population and increases replicative lifespan by 24%, linking RPL10 gene dosage to modulation of translation and aging. Yeast deletion genetics, polysome profiling, replicative lifespan assay Experimental gerontology Medium 17174052
2007 Extensive mutational analysis of yeast Rpl10 showed that mutations in a central loop (residues 102–112) significantly impair release of the 60S nuclear export adapter Nmd3, while Rpl10 mutants unable to bind the ribosome accumulate in the nucleus, suggesting a nuclear role. The central loop is unstructured in prokaryotic crystal/solution structures and plays a dynamic role in ribosome function or factor regulation. Systematic mutagenesis of RPL10, Nmd3 release assays, subcellular localization analysis in S. cerevisiae The Journal of biological chemistry High 17761675
2008 Yeast ribosomal protein L10's N-terminal 'hook' (which inserts into 25S rRNA helix 89 bulge) controls tRNA movement through the large subunit. Mutations in this domain cause broad effects on rRNA structure along the tRNA 3' end path, ribosome biogenesis, elongation factor binding, drug resistance, and translational fidelity, indicating L10 transduces conformational information through the ribosome. Yeast mutagenesis, killer virus maintenance assay (proxy for 60S defects), rRNA chemical modification (SHAPE/DMS), drug sensitivity, translational fidelity assays Nucleic acids research High 18824477
2008 The L10(L12)4 pentameric complex binds both mRNA leader and rRNA targets using structurally similar kink-turn RNA motifs. The ribosomal protein L11 enhances L10(L12)4 binding to rRNA by ~100-fold through a protein-protein interaction, ensuring saturation of the ribosomal binding site. mRNA and rRNA targets use equivalent kink-turn and loop-AA recognition elements but in different structural contexts. Fluorescence binding assays, mutagenesis of kink-turn motifs in mRNA and rRNA, quantitative affinity measurements using Bacillus stearothermophilus L10(L12)4 Biochemistry High 18247578
2012 Recurrent somatic mutations in RPL10 (most notably Arg98Ser, R98S) are found in ~10% of pediatric T-ALL patients. Yeast and lymphoid cells expressing RPL10 R98S showed a ribosome biogenesis defect. Exome sequencing of T-ALL patients, functional validation in yeast and lymphoid cells (ribosomal profiling) Nature genetics Medium 23263491
2013 An internal loop in yeast rpL10 acts as a central controller of ribosomal intersubunit rotation. Mutations in this loop cause opposing shifts in the rotational equilibrium between non-rotated and rotated ribosomal states, with allosteric effects propagating through both subunits and linking all functional centers. An rpL3 mutation with opposing structural effects suppresses an rpL10 mutant by re-establishing rotational equilibrium. The rpL10 loop is also involved in Sdo1p recruitment, linking rotational status to late-stage 60S maturation. rRNA chemical modification (DMS), ribosomal frameshifting assays, translational fidelity assays, genetic suppressor analysis, biochemical elongation factor binding assays in S. cerevisiae Nucleic acids research High 24214990
2014 A novel RPL10 missense mutation (p.K78E) causes X-linked microcephaly with seizures and growth retardation. Zebrafish rpl10 knockdown decreases head size with reduced bulk translation and increased apoptosis in the brain. In vivo complementation showed p.K78E is a loss-of-function variant. RPL10 is in close proximity to the peptidyl transferase active site of the 60S subunit. Zebrafish morpholino knockdown, bulk translation assays, apoptosis assays, in vivo complementation with wildtype vs mutant RPL10 Genetics High 25316788
2014 The antituberculosis antibiotic capreomycin inhibits the L12-L10 protein-protein interaction, thereby inhibiting elongation factor G-dependent GTPase activity and ribosome-mediated protein synthesis. Overexpression of L12 and/or L10 increases capreomycin MIC, and blocking protein synthesis with thiostrepton restrains capreomycin bactericidal activity. L12-L10 interaction assay, MIC measurements, in vitro GTPase activity assay, in vitro protein synthesis assay Antimicrobial agents and chemotherapy Medium 24449778
2015 A novel RPL10 missense mutation (p.A64V) in the N-terminal domain causes X-linked intellectual disability with cerebellar hypoplasia and spondylo-epiphyseal dysplasia. Unlike other RPL10 mutations, the A64V variant generates a functional ribosomal protein able to complement yeast translational defects but results in an increase in the actively translating ribosome population. Yeast complementation assay, polysome profiling, translational capacity measurement Human mutation Medium 26290468
2015 In Bacillus subtilis, the ribosomal protein L10(L12)4 complex autoregulates rplJL operon expression by a transcription attenuation mechanism: L10(L12)4 binds to an anti-antiterminator RNA structure in the rplJL leader transcript, stabilizing it and promoting formation of an intrinsic terminator, thereby repressing transcription. This is distinct from the E. coli translational repression mechanism. Transcriptional and translational fusions, RNA binding studies, in vitro transcription, competitor oligonucleotides, in vivo mutational analysis Nucleic acids research High 26101249
2016 Crystal structures of the eubacterial large ribosomal subunit in complex with orthosomycin antibiotics (avilamycin and evernimicin) revealed that ribosomal protein uL16 (RPL10 bacterial ortholog) participates in binding and discriminating A-tRNA at the A-tRNA entrance corridor. Structural analysis showed that differences in the α1 helix length of uL16 between eukaryotes and prokaryotes are key determinants of drug selectivity. High-resolution X-ray crystallography of large ribosomal subunit–antibiotic complexes Proceedings of the National Academy of Sciences of the United States of America High 27791159
2017 The T-ALL-associated RPL10 R98S mutation causes failure to release the 60S export adapter Nmd3 from the ribosomal P site. In vitro reconstitution showed Nmd3 inhibits Sdo1-stimulated Efl1 GTPase activity on RPL10 R98S but not wild-type 60S subunits. Suppressor mutations in Nmd3 and Tif6 that disrupted Nmd3-ribosome or Nmd3-Tif6 interactions rescued the defect in vivo and in vitro, defining the molecular defect of RPL10 R98S. In vitro reconstitution with purified components, Nmd3 release assays, Efl1 GTPase activity assays, suppressor genetic screen, yeast genetics PLoS genetics High 28715419
2017 The RPL10 R98S mutation causes overexpression of JAK-STAT signaling proteins in mouse lymphoid cells. RPL10 R98S expressing cells display JAK-STAT pathway hyper-activation upon cytokine stimulation. Mechanistically, RPL10 R98S reduces apparent programmed ribosomal frameshifting at JAK-STAT gene frameshift signals and decreases JAK1 degradation. RPL10 R98S cells also show reduced proteasome activity. Proteome screen, transgenic mouse model, xenograft T-ALL samples, cytokine stimulation assays, ribosomal frameshift reporter assays, proteasome activity assays Leukemia High 28744013
2018 RPL10 R98S mutant leukemia cells accumulate reactive oxygen species, causing mitochondrial dysfunction and reduced ATP levels, leading to a proliferation defect. These cells survive oxidative stress via specific upregulation of IRES-mediated translation of BCL-2 anti-apoptotic factor, resulting in BCL-2 protein overexpression and sensitivity to the BCL-2 inhibitor Venetoclax. ROS measurement, mitochondrial function assays, ATP quantification, IRES reporter assays, BCL-2 protein quantification, xenograft mouse model with Venetoclax treatment Leukemia High 29930300
2018 RPL10 in mitochondria of pancreatic cancer cells regulates ROS levels by affecting mitochondrial Complex I activity. ChIP-seq showed RPL10 is unlikely to function as a transcription factor. Transcriptome analysis indicated RPL10 regulates expression of proteins related to ROS production. Chromatin immunoprecipitation sequencing (ChIP-seq), transcriptome analysis, mitochondrial Complex I activity assay, ROS measurement Redox biology Medium 30172100
2023 RPL10 undergoes ufmylation (UFM1 modification) in pancreatic cancer tissues and cell lines, with specific modification sites identified and verified by mutagenesis. RPL10 ufmylation increases cell proliferation and stemness primarily through upregulation of the transcription factor KLF4. Mutagenesis of ufmylation sites in RPL10 confirmed the connection between ufmylation and these cellular phenotypes. Mass spectrometry identification of ufmylation sites, site-directed mutagenesis, cell proliferation assays, stemness assays, KLF4 expression analysis in patient tissues and cell lines Cell death & disease Medium 37280198

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2009 QM/MM methods for biomolecular systems. Angewandte Chemie (International ed. in English) 1720 19173328
2001 ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor. Immunity 949 11239445
2012 Exome sequencing identifies mutation in CNOT3 and ribosomal genes RPL5 and RPL10 in T-cell acute lymphoblastic leukemia. Nature genetics 336 23263491
2007 QM/MM studies of enzymes. Current opinion in chemical biology 242 17307018
2003 Human cytomegalovirus glycoprotein UL16 causes intracellular sequestration of NKG2D ligands, protecting against natural killer cell cytotoxicity. The Journal of experimental medicine 209 12782710
2006 Proteolytic release of soluble UL16-binding protein 2 from tumor cells. Cancer research 207 16510567
1991 The open reading frames UL3, UL4, UL10, and UL16 are dispensable for the replication of herpes simplex virus 1 in cell culture. Journal of virology 161 1846207
2003 Effects of human cytomegalovirus infection on ligands for the activating NKG2D receptor of NK cells: up-regulation of UL16-binding protein (ULBP)1 and ULBP2 is counteracted by the viral UL16 protein. Journal of immunology (Baltimore, Md. : 1950) 131 12847260
2001 The UL16-binding proteins, a novel family of MHC class I-related ligands for NKG2D, activate natural killer cell functions. Immunological reviews 105 11513139
2010 Plant L10 ribosomal proteins have different roles during development and translation under ultraviolet-B stress. Plant physiology 99 20516338
2006 Ribosomal proteins Rpl10 and Rps6 are potent regulators of yeast replicative life span. Experimental gerontology 99 17174052
2013 Convergence in the QM-only and QM/MM modeling of enzymatic reactions: A case study for acetylene hydratase. Journal of computational chemistry 97 23913757
2014 A novel ribosomopathy caused by dysfunction of RPL10 disrupts neurodevelopment and causes X-linked microcephaly in humans. Genetics 86 25316788
2006 Mutations in the ribosomal protein gene RPL10 suggest a novel modulating disease mechanism for autism. Molecular psychiatry 85 16940977
2016 QM/MM Calculations on Proteins. Methods in enzymology 76 27498637
2013 Effect of Geometry Optimizations on QM-Cluster and QM/MM Studies of Reaction Energies in Proteins. Journal of chemical theory and computation 75 26592409
2007 RAET1E2, a soluble isoform of the UL16-binding protein RAET1E produced by tumor cells, inhibits NKG2D-mediated NK cytotoxicity. The Journal of biological chemistry 68 17470428
1982 Autogenous control: ribosomal protein L10-L12 complex binds to the leader sequence of its mRNA. The EMBO journal 68 6765237
2012 Comparison of QM-Only and QM/MM Models for the Mechanism of Tungsten-Dependent Acetylene Hydratase. Journal of chemical theory and computation 67 26593020
2007 Dynamic interactions of the UL16 tegument protein with the capsid of herpes simplex virus. Journal of virology 67 17855514
2005 Complex formation between the UL16 and UL21 tegument proteins of pseudorabies virus. Journal of virology 66 15650177
1980 Autogenous control of Escherichia coli ribosomal protein L10 synthesis in vitro. Proceedings of the National Academy of Sciences of the United States of America 66 6994102
2021 Harder, better, faster, stronger: Large-scale QM and QM/MM for predictive modeling in enzymes and proteins. Current opinion in structural biology 65 34388673
2017 The T-cell leukemia-associated ribosomal RPL10 R98S mutation enhances JAK-STAT signaling. Leukemia 65 28744013
2008 The ribosomal protein L10/QM-like protein is a component of the NIK-mediated antiviral signaling. Virology 65 18789471
2009 Theoretical studies of RNA catalysis: hybrid QM/MM methods and their comparison with MD and QM. Methods (San Diego, Calif.) 64 19398008
2009 Interaction domains of the UL16 and UL21 tegument proteins of herpes simplex virus. Journal of virology 64 20042500
2014 QM/MM molecular dynamics studies of metal binding proteins. Biomolecules 62 25006697
2010 QM/MM approaches in medicinal chemistry research. Current topics in medicinal chemistry 61 19929827
2013 Eukaryotic rpL10 drives ribosomal rotation. Nucleic acids research 60 24214990
2008 Analysis of the interaction between the UL11 and UL16 tegument proteins of herpes simplex virus. Journal of virology 60 18715918
2018 The ribosomal RPL10 R98S mutation drives IRES-dependent BCL-2 translation in T-ALL. Leukemia 53 29930300
2006 Porcine UL16-binding protein 1 expressed on the surface of endothelial cells triggers human NK cytotoxicity through NKG2D. Journal of immunology (Baltimore, Md. : 1950) 53 16887974
2023 Best Practices on QM/MM Simulations of Biological Systems. Journal of chemical information and modeling 51 37100031
2003 Expression of the UL16 glycoprotein of Human Cytomegalovirus protects the virus-infected cell from attack by natural killer cells. BMC immunology 51 12694635
1989 Structure and evolution of the L11, L1, L10, and L12 equivalent ribosomal proteins in eubacteria, archaebacteria, and eucaryotes. Canadian journal of microbiology 45 2497941
2010 Structure of the HCMV UL16-MICB complex elucidates select binding of a viral immunoevasin to diverse NKG2D ligands. PLoS pathogens 43 20090832
1992 The UL16 gene of human cytomegalovirus encodes a glycoprotein that is dispensable for growth in vitro. Journal of virology 41 1328682
2018 QM/MM methods for free energies and photochemistry. Current opinion in structural biology 40 29414514
1979 Studies on the RNA and protein binding sites of the E. coli ribosomal protein L10. Nucleic acids research 40 379826
2023 Drug Design in the Exascale Era: A Perspective from Massively Parallel QM/MM Simulations. Journal of chemical information and modeling 39 37319347
2020 Both Configuration and QM Region Size Matter: Zinc Stability in QM/MM Models of DNA Methyltransferase. Journal of chemical theory and computation 39 32243149
2011 Direct and specific binding of the UL16 tegument protein of herpes simplex virus to the cytoplasmic tail of glycoprotein E. Journal of virology 39 21734044
1996 The primary structure of rat ribosomal protein L10: relationship to a Jun-binding protein and to a putative Wilms' tumor suppressor. Biochemical and biophysical research communications 39 8780716
2018 Ribosomal protein L10 in mitochondria serves as a regulator for ROS level in pancreatic cancer cells. Redox biology 38 30172100
2002 QM, a putative tumor suppressor, regulates proto-oncogene c-yes. The Journal of biological chemistry 38 12138090
2021 Open-Source Multi-GPU-Accelerated QM/MM Simulations with AMBER and QUICK. Journal of chemical information and modeling 37 33913331
1998 Characterization of the UL16 gene product of herpes simplex virus type 2. Archives of virology 36 9645194
2007 Mutational analysis of the ribosomal protein Rpl10 from yeast. The Journal of biological chemistry 35 17761675
1998 Assembly of the QM protein onto the 60S ribosomal subunit occurs in the cytoplasm. Journal of cellular biochemistry 34 9443083
2009 How mitogen-activated protein kinases recognize and phosphorylate their targets: A QM/MM study. Journal of the American Chemical Society 33 19361221
2023 The ufmylation modification of ribosomal protein L10 in the development of pancreatic adenocarcinoma. Cell death & disease 32 37280198
2020 Ribosomal protein QM/RPL10 positively regulates defence and protein translation mechanisms during nonhost disease resistance. Molecular plant pathology 30 32964634
2016 On-the-Fly QM/MM Docking with Attracting Cavities. Journal of chemical information and modeling 30 27983849
2015 A Novel Mutation in RPL10 (Ribosomal Protein L10) Causes X-Linked Intellectual Disability, Cerebellar Hypoplasia, and Spondylo-Epiphyseal Dysplasia. Human mutation 30 26290468
2014 The antituberculosis antibiotic capreomycin inhibits protein synthesis by disrupting interaction between ribosomal proteins L12 and L10. Antimicrobial agents and chemotherapy 30 24449778
2006 Human cytomegalovirus-encoded UL16 discriminates MIC molecules by their alpha2 domains. Journal of immunology (Baltimore, Md. : 1950) 30 16920952
2016 Mitochondrial Ribosomal Protein L10 Associates with Cyclin B1/Cdk1 Activity and Mitochondrial Function. DNA and cell biology 29 27726420
2020 Ribosomal Protein L10: From Function to Dysfunction. Cells 28 33227977
2008 Yeast ribosomal protein L10 helps coordinate tRNA movement through the large subunit. Nucleic acids research 28 18824477
2015 Sigma factor WhiGch positively regulates natamycin production in Streptomyces chattanoogensis L10. Applied microbiology and biotechnology 27 25724582
2009 Fluorine in protein environments: a QM and MD study. The journal of physical chemistry. B 27 19947631
2008 Mapping protein electron transfer pathways with QM/MM methods. Journal of the Royal Society, Interface 27 18445553
2021 Mechanisms of Proteolytic Enzymes and Their Inhibition in QM/MM Studies. International journal of molecular sciences 26 33810118
2018 QM/MM Calculations on Protein-RNA Complexes: Understanding Limitations of Classical MD Simulations and Search for Reliable Cost-Effective QM Methods. Journal of chemical theory and computation 26 30199638
2015 RPL10 mutation segregating in a family with X-linked syndromic Intellectual Disability. American journal of medical genetics. Part A 26 25846674
2004 Functional interaction in establishment of ribosomal integrity between small subunit protein rpS6 and translational regulator rpL10/Grc5p. FEMS yeast research 26 15556089
1994 Molecular phylogenies based on ribosomal protein L11, L1, L10, and L12 sequences. Journal of molecular evolution 26 8007008
2020 Differentiating the Roles of UL16, UL21, and Us3 in the Nuclear Egress of Herpes Simplex Virus Capsids. Journal of virology 25 32321804
2018 Biological Function of Ribosomal Protein L10 on Cell Behavior in Human Epithelial Ovarian Cancer. Journal of Cancer 25 29556332
2011 Comparison of QM-only and QM/MM models for the mechanism of tyrosinase. Faraday discussions 25 21322480
2009 Ribosomal protein L10 is encoded in the mitochondrial genome of many land plants and green algae. BMC evolutionary biology 25 19917118
2003 The human cytomegalovirus protein UL16 mediates increased resistance to natural killer cell cytotoxicity through resistance to cytolytic proteins. Journal of virology 25 12663760
2024 Software Infrastructure for Next-Generation QM/MM-ΔMLP Force Fields. The journal of physical chemistry. B 23 38905451
2008 Specific interactions of the L10(L12)4 ribosomal protein complex with mRNA, rRNA, and L11. Biochemistry 23 18247578
2018 Comparative Analysis of UL16 Mutants Derived from Multiple Strains of Herpes Simplex Virus 2 (HSV-2) and HSV-1 Reveals Species-Specific Requirements for the UL16 Protein. Journal of virology 22 29669832
2018 QM Cluster or QM/MM in Computational Enzymology: The Test Case of LigW-Decarboxylase. Frontiers in chemistry 22 30003076
2015 Thermodynamics calculation of protein-ligand interactions by QM/MM polarizable charge parameters. Journal of biomolecular structure & dynamics 22 25761118
2012 Identification and expression of small non-coding RNA, L10-Leader, in different growth phases of Streptococcus mutans. Nucleic acid therapeutics 22 22468692
2009 An investigation of ribosomal protein L10 gene in autism spectrum disorders. BMC medical genetics 22 19166581
2004 UL16 binding proteins. Immunobiology 22 15518340
2003 L10 ribosomal protein from Entamoeba histolytica share structural and functional homologies with QM/Jif-1: proteins with extraribosomal functions. Molecular and biochemical parasitology 22 12672524
2017 The Product of the Herpes Simplex Virus 2 UL16 Gene Is Critical for the Egress of Capsids from the Nuclei of Infected Cells. Journal of virology 21 28275195
2006 Expression of the NKG2D ligand UL16 binding protein-1 (ULBP-1) on dendritic cells. European journal of immunology 21 16342232
1999 Analysis of the pattern of QM expression during mouse development. Differentiation; research in biological diversity 21 10234813
2022 Factors That Determine the Variation of Equilibrium and Kinetic Properties of QM/MM Enzyme Simulations: QM Region, Conformation, and Boundary Condition. Journal of chemical theory and computation 19 35226489
2017 The T-cell leukemia related rpl10-R98S mutant traps the 60S export adapter Nmd3 in the ribosomal P site in yeast. PLoS genetics 19 28715419
2017 A de novo mutation in RPL10 causes a rare X-linked ribosomopathy characterized by syndromic intellectual disability and epilepsy: A new case and review of the literature. European journal of medical genetics 19 29066376
2016 Avilamycin and evernimicin induce structural changes in rProteins uL16 and CTC that enhance the inhibition of A-site tRNA binding. Proceedings of the National Academy of Sciences of the United States of America 19 27791159
1990 Escherichia coli ribosomal protein L10 is rapidly degraded when synthesized in excess of ribosomal protein L7/L12. Journal of bacteriology 19 2403546
2019 Differential Requirements for gE, gI, and UL16 among Herpes Simplex Virus 1 Syncytial Variants Suggest Unique Modes of Dysregulating the Mechanism of Cell-to-Cell Spread. Journal of virology 18 31092572
2019 QM/MM study of the taxadiene synthase mechanism. Journal of computational chemistry 17 31062376
2018 Glycoprotein D of HSV-1 is dependent on tegument protein UL16 for packaging and contains a motif that is differentially required for syncytia formation. Virology 17 30465930
2017 Identification of Mycobacterial RplJ/L10 and RpsA/S1 Proteins as Novel Targets for CD4+ T Cells. Infection and immunity 17 28115505
2015 Ribosomal protein L10(L12)4 autoregulates expression of the Bacillus subtilis rplJL operon by a transcription attenuation mechanism. Nucleic acids research 17 26101249
2006 The human cytomegalovirus glycoprotein UL16 traffics through the plasma membrane and the nuclear envelope. Cellular microbiology 17 16548884
2005 Overexpression of QM induces cell differentiation and mineralization in MC3T3-E1. Biological & pharmaceutical bulletin 17 16079476
2022 Predicting Effects of Site-Directed Mutagenesis on Enzyme Kinetics by QM/MM and QM Calculations: A Case of Glutamate Carboxypeptidase II. The journal of physical chemistry. B 15 34978450
2017 Domain Interaction Studies of Herpes Simplex Virus 1 Tegument Protein UL16 Reveal Its Interaction with Mitochondria. Journal of virology 15 27847362
2013 QM and QM/MM simulations of proteins. Methods in molecular biology (Clifton, N.J.) 15 23034747

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