Affinage

YES1

Tyrosine-protein kinase Yes · UniProt P07947

Length
543 aa
Mass
60.8 kDa
Annotated
2026-06-11
100 papers in source corpus 20 papers cited in narrative 20 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

YES1 is a non-receptor Src-family tyrosine kinase that drives cell proliferation, survival, migration, and oncogenic transformation by phosphorylating distinct substrates in a manner that is non-redundant with c-Src (PMID:37936984, PMID:16400523). A recurrent output of YES1 signaling is control of the transcriptional coactivators YAP/TAZ: YES1 phosphorylates YAP/TAZ and promotes their nuclear accumulation and transcriptional activity, and these effectors are required for YES1-dependent oncogenic transformation of hepatocytes (PMID:35041461, PMID:31391186). YES1 also phosphorylates ANXA2 at Tyr24 downstream of the EphA2 receptor to promote invasion (PMID:33941853), VE-cadherin to govern endothelial junction turnover, endocytosis, and vascular integrity in a flow-dependent manner (PMID:37936984), and the transporter OCT1 to regulate its activity (PMID:33790797). Beyond YAP/TAZ, YES1 engages mTOR signaling to drive lung tumor growth and metastasis (PMID:31166114). Its kinase activity is set by both inhibitory and activating inputs: Ca2+-dependent association with inhibitory proteins suppresses c-Yes activity (distinct from c-Src) (PMID:8246968), ACSL3 binds YES1 and suppresses its Tyr419 activation (PMID:38953696), membrane anchoring by the SMIM30 peptide promotes its phosphorylation (PMID:32461121), and the mislocalized scaffold Scrib recruits the active, αC-helix-in conformer to enhance YAP1-Y357 phosphorylation independently of canonical Hippo signaling (PMID:33730553); transcriptionally, the Ets factor Etv2 directly binds the YES1 promoter to control its expression during embryogenesis (PMID:31278282). Clinically, YES1 amplification confers sensitivity to the SFK inhibitor dasatinib and drives resistance to HER2-targeted therapies, which dasatinib can reverse (PMID:31166114, PMID:32572172, PMID:31856375).

Mechanistic history

Synthesis pass · year-by-year structured walk · 10 steps
  1. 1993 High

    Established that c-Yes is regulated differently from its closest relative c-Src, answering whether SFK members are functionally interchangeable.

    Evidence in vitro kinase assays, immunoprecipitation, and Ca2+-supplemented extracts with EGTA reversal in mammalian cells

    PMID:8246968

    Open questions at the time
    • The identity of the Ca2+-dependent inhibitory protein(s) was not molecularly defined
    • Physiological contexts triggering this Ca2+-dependent inhibition were not established
  2. 2005 High

    Showed YES1 has cellular roles non-redundant with c-Src by defining specific requirements in West Nile virus maturation and in BLT1-driven neutrophil degranulation.

    Evidence RNAi knockdown distinguishing Yes from Src, PP2/PP1 inhibitors, dominant-negative dynamin, EndoH digestion, and selective kinase activity assays

    PMID:15749899 PMID:16140770

    Open questions at the time
    • Direct YES1 substrates in viral glycoprotein trafficking and neutrophil degranulation were not identified
    • How endocytosis couples to selective Yes activation was not resolved
  3. 2006 Medium

    Demonstrated a unique YES1 function in VEGF-induced endothelial migration distinct from Src and Fyn, refining the division of labor among SFKs in angiogenesis.

    Evidence selective RNAi of individual SFKs with migration, proliferation, and tube formation assays in retinal microvascular endothelial cells

    PMID:16400523

    Open questions at the time
    • No substrate linking YES1 to migration machinery was identified
    • Single lab; mechanism downstream of VEGF receptor not mapped
  4. 2013 Low

    Extended YES1 function to anti-apoptotic stress signaling in germ cells and introduced a miRNA-based control of YES1 abundance.

    Evidence SU6656 inhibition with ERK/MTA1/p53 readout in spermatocytes, and luciferase 3'UTR validation of miR-210 targeting in HCC cells

    PMID:24132961 PMID:26676187

    Open questions at the time
    • miR-210 link is indirect with no direct kinase assay
    • Whether YES1 directly phosphorylates ERK-pathway components was not tested
  5. 2019 High

    Identified YAP1 as a downstream effector of YES1 kinase activity and mTOR as a parallel oncogenic output, defining the core proliferative circuitry exploited in YES1-amplified cancers.

    Evidence CRISPR/shRNA depletion, YES1 inhibitor CH6953755, nuclear fractionation, phosphorylation and reporter assays, and PDX models in lung cancer

    PMID:31166114 PMID:31391186

    Open questions at the time
    • Whether YES1 directly versus indirectly phosphorylates YAP1 was not fully resolved at this stage
    • Relative contributions of YAP1 versus mTOR arms not dissected
  6. 2019 Medium

    Placed YES1 under direct transcriptional control of Etv2, establishing how YES1 expression is set during development.

    Evidence ChIP-seq, doxycycline-inducible Etv2 ES/EB system, luciferase reporter, and Etv2-null embryoid bodies

    PMID:31278282

    Open questions at the time
    • Functional consequence of Etv2-driven YES1 expression in vivo not established
    • Other transcriptional regulators of YES1 not surveyed
  7. 2020 Medium

    Defined a membrane-anchoring activation mechanism via the SMIM30 micropeptide and clarified YES1 amplification as a driver of resistance to HER2-targeted therapy.

    Evidence RIP-seq, co-IP/pulldown with MAPK readout in HCC; T-DM1 acquired-resistance modeling with copy number analysis, siRNA, and dasatinib rescue in xenografts

    PMID:32461121 PMID:32572172

    Open questions at the time
    • SMIM30 binding interface and selectivity for YES1 versus SRC not structurally defined
    • Which downstream pathway (EGFR/PI3K/MAPK) is rate-limiting for resistance not isolated
  8. 2021 High

    Mapped specific YES1 substrate-effector relationships: ANXA2-Tyr24 downstream of EphA2, OCT1 tyrosine phosphorylation, and Scrib-scaffolded YAP1-Y357 phosphorylation independent of Hippo.

    Evidence co-IP, Tyr24F mutagenesis and invasion assays (ANXA2); phospho-proteomics with dasatinib and in vivo biomarker (OCT1); HaloPROTAC degradation, AP-MS, and conformation-selective binding (Scrib)

    PMID:33730553 PMID:33790797 PMID:33941853

    Open questions at the time
    • Generality of EphA2-YES1-ANXA2 axis beyond gastric cancer not established
    • Direct kinase-substrate reconstitution for OCT1 and YAP1-Y357 not performed
    • How Scrib selects the active YES1 conformer mechanistically unresolved
  9. 2022 High

    Solidified YES1 as a YAP/TAZ-activating kinase in hepatocytes and endothelial-junction kinase, and revealed a replisome/DNA-repair vulnerability conferring radiosensitivity.

    Evidence transgenic activated-YES1 mouse hepatocytes with epistasis (HCC); EC-specific YES1 knockout mice with live imaging and VE-cadherin internalization; CRISPR/shRNA, CH6953755/dasatinib, organoids and PDX with transcriptomics (SCLC)

    PMID:35041461 PMID:35988891 PMID:37936984

    Open questions at the time
    • Direct YES1 substrate in the replisome/DNA-repair response not identified
    • Mechanism linking junctional VE-cadherin phosphorylation to collective migration not fully resolved
  10. 2024 Medium

    Identified ACSL3 as a negative regulator of YES1 activation, adding a brake on the YES1-YAP1 axis.

    Evidence co-IP, Tyr419 phosphorylation assays, nuclear fractionation, and gain/loss-of-function in breast cancer cells and in vivo

    PMID:38953696

    Open questions at the time
    • Whether ACSL3 directly competes with activating inputs or sequesters YES1 not defined
    • Single lab; reciprocal validation limited

Open questions

Synthesis pass · forward-looking unresolved questions
  • Whether the multiple activating and inhibitory inputs (SMIM30, Scrib, EphA2, Ca2+-proteins, ACSL3) converge on a single conformational switch governing YES1 substrate selection across tissues remains unresolved.
  • No unified structural model of YES1 activation states
  • Substrate-selection rules distinguishing YAP/TAZ versus VE-cadherin versus ANXA2 contexts not established

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140096 catalytic activity, acting on a protein 5 GO:0016740 transferase activity 4
Localization
GO:0005886 plasma membrane 2 GO:0005829 cytosol 1
Pathway
R-HSA-162582 Signal Transduction 5 R-HSA-1643685 Disease 4
Partners
ACSL3ANXA2EPHA2SCRIBSMIM30TAZVE-CADHERINYAP1

Evidence

Reading pass · 20 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2020 The small peptide SMIM30, encoded by lncRNA LINC00998, drives membrane anchoring of YES1 (and SRC) by directly binding to them, thereby promoting YES1 phosphorylation and activating the downstream MAPK signaling pathway in hepatocellular carcinoma cells. RIP-seq, co-immunoprecipitation/pulldown, functional overexpression/knockdown assays, MAPK pathway readout Journal of hepatology Medium 32461121
2022 YES1 (c-Yes tyrosine kinase), rather than Src, is specifically localized at endothelial cell junctions where it becomes activated in a flow-dependent manner, phosphorylates VE-cadherin to regulate its constitutive turnover and endocytosis, and thereby maintains endothelial junction plasticity and vascular integrity. EC-specific YES1 deletion suppressed VE-cadherin phosphorylation and arrested VE-cadherin at junctions, causing loss of collective migration and exaggerated agonist-induced leakage. Endothelial cell-specific YES1 knockout mice, live imaging, phosphorylation assays, VE-cadherin internalization assays, comparison with Src-deficient ECs Nature cardiovascular research High 37936984
2021 YES1 is a substrate and effector of the EphA2 receptor tyrosine kinase: EphA2 activates YES1, which then phosphorylates ANXA2 at Tyr24, leading to ANXA2 activation and increased nuclear distribution of ANXA2 in gastric cancer cells, promoting invasion and migration. Co-immunoprecipitation, knockdown/overexpression, site-directed mutagenesis (ANXA2 Tyr24F mutant), in vitro invasion/migration assays, mouse xenograft models Oncogene High 33941853
2022 YES1 signaling promotes nuclear accumulation and transcriptional activity of YAP and TAZ in hepatocellular carcinoma cells and liver tumors. YES1 phosphorylates YAP/TAZ, driving their nuclear accumulation, and YAP/TAZ are required effectors of YES1-dependent oncogenic transformation of hepatocytes. Genetic (transgenic expression of activated YES1 in mouse hepatocytes) and pharmacological interventions, phosphorylation assays, nuclear fractionation, epistasis experiments in cellular and mouse HCC models Science signaling High 35041461
2019 YES1 drives lung cancer growth and metastasis primarily through mTOR signaling. YES1 genetic depletion (CRISPR/Cas9) significantly reduced tumor growth and metastasis in preclinical models, and YES1 gene amplification confers high sensitivity to the SFK inhibitor dasatinib. CRISPR/Cas9 knockout, in vivo tumor and metastasis models, patient-derived xenografts, mTOR signaling pathway analysis by immunoblotting American journal of respiratory and critical care medicine High 31166114
2019 YES1 regulates YAP1 transcriptional activity by controlling YAP1 nuclear translocation and serine phosphorylation in YES1-amplified cancer cells, placing YAP1 as a downstream effector of YES1 kinase activity. shRNA knockdown, YES1-specific kinase inhibitor (CH6953755), nuclear fractionation, phosphorylation assays, transcriptional reporter assays Cancer research Medium 31391186
1993 c-Yes kinase is inactivated by elevation of intracellular calcium levels through a Ca2+-dependent association with specific cellular proteins, which forms complexes not seen with c-Src, and one of these proteins can inhibit c-Yes kinase activity in vitro. This regulation is distinct from c-Src, which is activated under the same conditions. In vitro kinase assays, immunoprecipitation, gradient sedimentation, Ca2+-supplemented cell extracts, protein tyrosine phosphatase treatment, EGTA reversal Molecular and cellular biology High 8246968
2005 c-Yes kinase activity is specifically required for West Nile virus particle maturation: RNAi knockdown of c-Yes (but not c-Src) reduces virus yield, and Yes kinase activity is needed for the viral envelope glycoprotein E to transit beyond the endoplasmic reticulum, enabling virion egress through the secretory pathway. RNA interference knockdown, SFK inhibitor PP2 treatment, endoglycosidase H digestion of viral envelope glycoprotein, electron microscopy, viral titer assays Journal of virology High 16140770
2006 YES1 (c-Yes) plays a unique and non-redundant role in VEGF-mediated endothelial cell migration: selective knockdown of Yes (but not Src or Fyn) by RNAi significantly decreased VEGF-induced cell migration in human retinal microvascular endothelial cells, while all three kinases were required for VEGF mitogenic signaling. RNA interference selective knockdown of individual Src family kinases, VEGF-induced migration assay, proliferation assay, tube formation assay Angiogenesis Medium 16400523
2005 c-Yes kinase is specifically activated downstream of the leukotriene B4 high-affinity receptor BLT1 following LTB4 stimulation of neutrophils, and BLT1 endocytosis is required for Yes kinase activation. Yes kinase activation (but not c-Src or other SFKs) is required for LTB4-induced neutrophil degranulation. Src family kinase inhibitor PP1, dominant-negative dynamin (endocytosis block), selective kinase activity assays for individual SFKs, degranulation enzyme release assay Journal of immunology Medium 15749899
2021 Mislocalized Scribble (Scrib) scaffolds active YES1 (preferentially in its kinase-active, αC helix-in conformation) in the cytoplasm, enhancing YAP1 phosphorylation at Y357. Scrib HaloPROTAC degradation attenuates YAP1-Y357 phosphorylation, and Snail-induced Scrib mislocalization promotes YAP1 nuclear localization independently of Hippo-regulated YAP-S127 phosphorylation. HaloTag genome engineering, PROTAC degradation, affinity purification mass spectrometry, phosphorylation assays, confocal imaging Cell chemical biology Medium 33730553
2013 YES1 activation in mouse pachytene spermatocytes in response to heat stress is anti-apoptotic, operating via the ERK/MTA1/p53 cascade. Co-culture with Sertoli cells enhances heat stress-induced YES1 activation through paracrine signaling. Pharmacological inhibition of YES1 with SU6656 dramatically increased heat stress-induced apoptosis. Primary cell culture, YES1 selective inhibitor SU6656, co-culture with Sertoli cells, apoptosis assays, immunoblotting for ERK/MTA1/p53 Biology of reproduction Medium 24132961
2021 YES1 phosphorylates OCT1 (organic cation transporter 1) on tyrosine residues, and YES1 kinase inhibition by dasatinib suppresses OCT1 transporter activity both in cells and in mice, as demonstrated by modulation of the OCT1 biomarker isobutyryl L-carnitine. Phospho-proteomics screen, genetic and pharmacological inhibition of YES1 (dasatinib), targeted metabolomics for OCT1 biomarker, in vivo mouse studies Frontiers in pharmacology Medium 33790797
2019 Etv2 (an Ets transcription factor) directly binds to the promoter region of YES1 and functions as a transcriptional regulator of YES1 during embryogenesis. Etv2 induction increases YES1 transcript levels dose-dependently, and YES1 is reduced in Etv2 null embryoid bodies. ChIP-seq, RNA-seq, doxycycline-inducible Etv2 ES/EB system, luciferase reporter assay, promoter binding assays, single-cell RNA-seq Scientific reports Medium 31278282
2024 ACSL3 interacts with YES1 and suppresses its activation (phosphorylation at Tyr419). Decreased active YES1 consequently inhibits YAP1 nuclear colocalization and transcriptional complex formation in breast cancer cells. Co-immunoprecipitation (ACSL3-YES1 interaction), phosphorylation assays (Tyr419), nuclear fractionation, gain- and loss-of-function assays, in vitro and in vivo experiments Cancer biology & medicine Medium 38953696
2022 YES1 promotes YAP1 nuclear translocation and drives gastric cancer cell proliferation. In the linc01133/miR-145-5p/YES1 axis, YES1 upregulation increases CDK4, CDK6, and cyclin D1 to promote G1-S phase transition via YAP1 nuclear translocation. ceRNA sponging assays, luciferase reporter assay, YES1 knockdown/overexpression, nuclear fractionation, cell cycle analysis Cell death & disease Low 35017464
2020 YES1 amplification leads to resistance to trastuzumab-emtansine (T-DM1) and cross-resistance to all types of HER2-targeted drugs. YES1 activates multiple proliferation-related signaling pathways including EGFR, PI3K, and MAPK. Inhibiting YES1 with dasatinib sensitizes resistant cells in vitro and in vivo. Acquired resistance modeling with escalating T-DM1, gene copy number analysis, siRNA knockdown and stable overexpression, western blotting for signaling pathways, xenograft models British journal of cancer Medium 32572172
2020 YES1 amplification confers resistance to neratinib (HER2 TKI) in HER2-amplified breast and lung cancers. YES1 activation leads to downregulation of HER2, AKT, and MAPK signaling upon combined dasatinib treatment. Knockdown of YES1 by siRNA or pharmacological inhibition by dasatinib restored neratinib sensitivity. Acquisition of drug resistance by escalating drug exposure, copy number analysis, siRNA knockdown, pharmacological inhibition, in vitro and in vivo (xenograft) studies, signaling pathway analysis Cancer science Medium 31856375
2022 YES1 inhibition in SCLC cells causes alterations in the replisome and DNA repair processes, conferring sensitivity to irradiation, in addition to reducing proliferation and inducing apoptosis. YES1 protein is detectable in plasma exosomes from patients and mouse models. Genetic depletion (CRISPR/shRNA), pharmacological inhibition (CH6953755/dasatinib), organoid models, patient-derived xenografts, transcriptomic analysis of replisome/DNA repair pathways, irradiation sensitivity assays Journal of thoracic oncology Medium 35988891
2013 miR-210 directly targets the 3'UTR of YES1 mRNA and reduces YES1 protein expression, thereby suppressing hepatocellular carcinoma cell proliferation and cell cycle progression. Luciferase reporter assay (3'UTR binding), siRNA knockdown of YES1, miR-210 mimic/inhibitor transfection, flow cytometry cell cycle analysis, proliferation assay World journal of gastroenterology Low 26676187

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2008 Expression of Yes-associated protein in common solid tumors. Human pathology 484 18703216
2008 Mst2 and Lats kinases regulate apoptotic function of Yes kinase-associated protein (YAP). The Journal of biological chemistry 311 18640976
2013 Yes-associated protein up-regulates Jagged-1 and activates the Notch pathway in human hepatocellular carcinoma. Gastroenterology 286 23419361
1986 yes-related protooncogene, syn, belongs to the protein-tyrosine kinase family. Proceedings of the National Academy of Sciences of the United States of America 243 3526330
2015 Yes-associated protein regulates endothelial cell contact-mediated expression of angiopoietin-2. Nature communications 207 25962877
2016 Yes-associated protein mediates immune reprogramming in pancreatic ductal adenocarcinoma. Oncogene 188 27546622
2020 Peptide SMIM30 promotes HCC development by inducing SRC/YES1 membrane anchoring and MAPK pathway activation. Journal of hepatology 185 32461121
2013 Wnt your brain be inflamed? Yes, it Wnt! Trends in molecular medicine 140 23312954
2011 Yes-associated protein 1 is widely expressed in human brain tumors and promotes glioblastoma growth. Journal of neuropathology and experimental neurology 138 21666501
2017 Co-activation of STAT3 and YES-Associated Protein 1 (YAP1) Pathway in EGFR-Mutant NSCLC. Journal of the National Cancer Institute 135 28376152
2016 Long noncoding RNA H19 competitively binds miR-17-5p to regulate YES1 expression in thyroid cancer. The FEBS journal 132 27093644
2017 miR-140-5p suppresses the proliferation, migration and invasion of gastric cancer by regulating YES1. Molecular cancer 123 28818100
2004 The p53 protein family and radiation sensitivity: Yes or no? Cancer metastasis reviews 103 15197326
2015 Are Platelets Cells? And if Yes, are They Immune Cells? Frontiers in immunology 101 25750642
2015 Yes-Associated Protein is up-regulated by mechanical overload and is sufficient to induce skeletal muscle hypertrophy. FEBS letters 95 25959868
2011 Yes-associated protein regulation of adaptive liver enlargement and hepatocellular carcinoma development in mice. Hepatology (Baltimore, Md.) 84 21391223
2021 EphA2-YES1-ANXA2 pathway promotes gastric cancer progression and metastasis. Oncogene 69 33941853
2005 The Src family kinase c-Yes is required for maturation of West Nile virus particles. Journal of virology 69 16140770
2023 The beneficial role of autophagy in multiple sclerosis: Yes or No? Autophagy 65 37712858
2012 Yes-associated protein 1 is activated and functions as an oncogene in meningiomas. Molecular cancer research : MCR 62 22618028
2019 YES1 Drives Lung Cancer Growth and Progression and Predicts Sensitivity to Dasatinib. American journal of respiratory and critical care medicine 60 31166114
2014 Yes-associated protein 1 (YAP1) promotes human gallbladder tumor growth via activation of the AXL/MAPK pathway. Cancer letters 60 25218593
2019 YES1 Is a Targetable Oncogene in Cancers Harboring YES1 Gene Amplification. Cancer research 54 31391186
2017 Expression of YES-associated protein (YAP) and its clinical significance in breast cancer tissues. Human pathology 51 28899737
2017 Dual roles of yes-associated protein (YAP) in colorectal cancer. Oncotarget 49 29088905
2022 YES1: A Novel Therapeutic Target and Biomarker in Cancer. Molecular cancer therapeutics 47 35732509
2022 β-Catenin Sustains and Is Required for YES-associated Protein Oncogenic Activity in Cholangiocarcinoma. Gastroenterology 46 35489428
2006 Src, Fyn and Yes play differential roles in VEGF-mediated endothelial cell events. Angiogenesis 46 16400523
2014 Yes-associated protein (YAP) modulates oncogenic features and radiation sensitivity in endometrial cancer. PloS one 45 24972085
2015 Expression of Yes-associated protein (YAP) in metastatic breast cancer. International journal of clinical and experimental pathology 43 26617849
2014 The Yes-associated protein controls the cell density regulation of Hedgehog signaling. Oncogenesis 43 25111861
2022 Tyrosine-protein kinase Yes controls endothelial junctional plasticity and barrier integrity by regulating VE-cadherin phosphorylation and endocytosis. Nature cardiovascular research 42 37936984
2015 MiR-17-5p up-regulates YES1 to modulate the cell cycle progression and apoptosis in ovarian cancer cell lines. Journal of cellular biochemistry 42 25561420
2010 Elevated c-Src and c-Yes expression in malignant skin cancers. Journal of experimental & clinical cancer research : CR 42 20796316
2016 IQGAP1 Binds to Yes-associated Protein (YAP) and Modulates Its Transcriptional Activity. The Journal of biological chemistry 39 27440047
2014 Yes! Sex matters: sex, the brain and blood pressure. Current hypertension reports 39 24929952
2011 Differences in Yes-associated protein and mRNA levels in regenerating liver and hepatocellular carcinoma. Molecular medicine reports 39 22012126
2005 Involvement of BLT1 endocytosis and Yes kinase activation in leukotriene B4-induced neutrophil degranulation. Journal of immunology (Baltimore, Md. : 1950) 39 15749899
2004 NO means no and yes: regulation of cell signaling by protein nitrosylation. Free radical research 37 15061648
2020 Endothelial cell HSPA12B and yes-associated protein cooperatively regulate angiogenesis following myocardial infarction. JCI insight 35 32790647
2018 Yes-associated protein promotes the abnormal proliferation of psoriatic keratinocytes via an amphiregulin dependent pathway. Scientific reports 35 30323299
2013 The hippo-yes association protein pathway in liver cancer. Gastroenterology research and practice 35 23986776
2019 Yes-associated protein regulates podocyte cell cycle re-entry and dedifferentiation in adriamycin-induced nephropathy. Cell death & disease 34 31801948
1993 Inactivation of c-Yes tyrosine kinase by elevation of intracellular calcium levels. Molecular and cellular biology 33 8246968
2019 β-Catenin and Yes-Associated Protein 1 Cooperate in Hepatoblastoma Pathogenesis. The American journal of pathology 32 30794807
2013 YES1 activation elicited by heat stress is anti-apoptotic in mouse pachytene spermatocytes. Biology of reproduction 32 24132961
2012 C-Src and c-Yes are two unlikely partners of spermatogenesis and their roles in blood-testis barrier dynamics. Advances in experimental medicine and biology 31 23397631
2020 Progesterone, via yes-associated protein, promotes cardiomyocyte proliferation and cardiac repair. Cell proliferation 30 33047378
2020 Circ_0057553/miR-515-5p Regulates Prostate Cancer Cell Proliferation, Apoptosis, Migration, Invasion and Aerobic Glycolysis by Targeting YES1. OncoTargets and therapy 30 33177837
2016 Yes-associated protein impacts adherens junction assembly through regulating actin cytoskeleton organization. American journal of physiology. Gastrointestinal and liver physiology 30 27229120
2015 miR-203 downregulates Yes-1 and suppresses oncogenic activity in human oral cancer cells. Journal of bioscience and bioengineering 29 25910964
2022 miR-133a targets YES1 to reduce cisplatin resistance in ovarian cancer by regulating cell autophagy. Cancer cell international 28 35012539
2013 Identification of potent Yes1 kinase inhibitors using a library screening approach. Bioorganic & medicinal chemistry letters 28 23787099
2022 Linc01133 contributes to gastric cancer growth by enhancing YES1-dependent YAP1 nuclear translocation via sponging miR-145-5p. Cell death & disease 26 35017464
2018 Yes-associated protein enhances proliferation and attenuates sensitivity to cisplatin in human gastric cancer cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 25 30021363
2014 Expression of Yes-associated protein in cervical squamous epithelium lesions. International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 25 25304677
2006 Yes-associated protein (YAP65) in relation to Smad7 expression in human pancreatic ductal adenocarcinoma. International journal of molecular medicine 25 16596258
2022 Matrix Mechanotransduction via Yes-Associated Protein in Human Lamina Cribrosa Cells in Glaucoma. Investigative ophthalmology & visual science 24 35015027
2020 YES1 amplification confers trastuzumab-emtansine (T-DM1) resistance in HER2-positive cancer. British journal of cancer 24 32572172
2022 Bioactive Phytoconstituents as Potent Inhibitors of Tyrosine-Protein Kinase Yes (YES1): Implications in Anticancer Therapeutics. Molecules (Basel, Switzerland) 23 35630545
2020 YES1 activation induces acquired resistance to neratinib in HER2-amplified breast and lung cancers. Cancer science 23 31856375
2019 CCN1-Yes-Associated Protein Feedback Loop Regulates Physiological and Pathological Angiogenesis. Molecular and cellular biology 23 31262999
2021 Influence of YES1 Kinase and Tyrosine Phosphorylation on the Activity of OCT1. Frontiers in pharmacology 22 33790797
2020 Yes-Associated Protein 1: Role and Treatment Prospects in Orthopedic Degenerative Diseases. Frontiers in cell and developmental biology 22 33178690
2022 YES1 Is a Druggable Oncogenic Target in SCLC. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 21 35988891
2021 Hippo/yes-associated protein signaling functions as a mechanotransducer in regulating vascular homeostasis. Journal of molecular and cellular cardiology 21 34547259
2017 Yes-associated protein 1 promotes the differentiation and mineralization of cementoblast. Journal of cellular physiology 21 28688217
1991 Distribution of c-yes-1 gene product in various cells and tissues. British journal of cancer 21 2021534
2021 Scribble sub-cellular localization modulates recruitment of YES1 to regulate YAP1 phosphorylation. Cell chemical biology 20 33730553
2020 Long non-coding TUG1 accelerates prostate cancer progression through regulating miR-128-3p/YES1 axis. European review for medical and pharmacological sciences 20 32016963
2015 Up-regulation of microRNA-210 inhibits proliferation of hepatocellular carcinoma cells by targeting YES1. World journal of gastroenterology 20 26676187
2023 The yes-associated protein (YAP) is associated with resistance to anti-GD2 immunotherapy in neuroblastoma through downregulation of ST8SIA1. Oncoimmunology 19 37554309
2024 ACSL3 regulates breast cancer progression via lipid metabolism reprogramming and the YES1/YAP axis. Cancer biology & medicine 18 38953696
2018 Yes-associated protein promotes early hepatocyte cell cycle progression in regenerating liver after tissue loss. FASEB bioAdvances 18 30740593
2015 Role of Yes-associated protein 1 in gliomas: pathologic and therapeutic aspects. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 18 25750037
2023 Yes-Associated Protein Mediates the Transition from Inflammation to Fibrosis in Graves' Orbitopathy. Thyroid : official journal of the American Thyroid Association 17 37800725
2023 A New Player in the Mechanobiology of Deep Fascia: Yes-Associated Protein (YAP). International journal of molecular sciences 17 37895068
2020 Phosphorylated Ezrin (Thr567) Regulates Hippo Pathway and Yes-Associated Protein (Yap) in Liver. The American journal of pathology 17 32289287
2019 Time is on the Immune System's Side, Yes it is. The Yale journal of biology and medicine 17 31249483
2013 The Src family kinases: distinct functions of c-Src, Yes, and Fyn in the liver. Biomolecular concepts 17 25436571
2010 Transcriptional profiling of the nucleus pulposus: say yes to notochord. Arthritis research & therapy 17 20497604
2005 c-Yes response to growth factor activation. Growth factors (Chur, Switzerland) 17 16338789
2020 MiR-133 Targets YES1 and Inhibits the Growth of Triple-Negative Breast Cancer Cells. Technology in cancer research & treatment 16 32462982
2020 Inhibition of yes-associated protein dephosphorylation prevents aggravated periodontitis with occlusal trauma. Journal of periodontology 16 33094479
2017 Expression of Yes-associated protein 1 and its clinical significance in ovarian serous cystadenocarcinoma. Oncology reports 16 28339095
2021 Circ-ZNF124 downregulation inhibits non-small cell lung cancer progression partly by inactivating the Wnt/β-catenin signaling pathway via mediating the miR-498/YES1 axis. Anti-cancer drugs 15 33186139
2019 Deficiency of Yes-Associated Protein Induces Cataract in Mice. Aging and disease 15 31011480
2024 Emerging Roles of YES1 in Cancer: The Putative Target in Drug Resistance. International journal of molecular sciences 14 38338729
2024 The role of yes activated protein (YAP) in melanoma metastasis. iScience 14 38770136
2023 Yes-associated protein nuclear translocation promotes anabolic activity in human articular chondrocytes. Osteoarthritis and cartilage 14 37100374
2022 Signaling by the tyrosine kinase Yes promotes liver cancer development. Science signaling 14 35041461
2022 Yes-associated protein promotes endothelial-to-mesenchymal transition of endothelial cells in choroidal neovascularization fibrosis. International journal of ophthalmology 14 35601164
2022 Intermittent compressive force regulates human periodontal ligament cell behavior via yes-associated protein. Heliyon 14 36247165
2021 Yes, MAM! Molecular & cellular oncology 14 34616865
2019 RNA-binding protein QKI regulates contact inhibition via Yes-associate protein in ccRCC. Acta biochimica et biophysica Sinica 14 30566575
2024 Yes, polygenic sex determination is a thing! Trends in genetics : TIG 13 39505660
2022 Circ_0081143 Contributes to Gastric Cancer Malignant Development and Doxorubicin Resistance by Elevating the Expression of YES1 by Targeting mziR-129-2-3p. Gut and liver 13 35686503
2021 Matrine Regulates Proliferation, Apoptosis, Cell Cycle, Migration, and Invasion of Non-Small Cell Lung Cancer Cells Through the circFUT8/miR-944/YES1 Axis. Cancer management and research 13 33907466
2023 Yes-Associated Protein and Transcriptional Coactivator with PDZ-Binding Motif in Cardiovascular Diseases. International journal of molecular sciences 12 36675179
2019 Etv2 transcriptionally regulates Yes1 and promotes cell proliferation during embryogenesis. Scientific reports 12 31278282

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