Affinage

TPT1

Translationally-controlled tumor protein · UniProt P13693

Length
172 aa
Mass
19.6 kDa
Annotated
2026-06-10
100 papers in source corpus 35 papers cited in narrative 34 extracted findings
Cross-family judge vs UniProt: tie faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

TPT1 (TCTP/fortilin) is a multifunctional cytoprotective protein that integrates pro-survival, growth, and developmental signaling, and whose loss is embryonically lethal in mice (PMID:11598139, PMID:18274553, PMID:19364479). Its dominant function is suppression of apoptosis through convergent mechanisms: it inserts into the mitochondrial membrane to inhibit Bax dimerization via a Bax-like H2–H3 helical region (PMID:18274553), it contains a BH3-like domain that—unlike all other BH3 proteins—activates rather than inhibits the anti-apoptotic activity of Bcl-xL (PMID:26813996), and it sequesters intracellular Ca²⁺ through N-terminal residues to block Ca²⁺-dependent death (PMID:17705784). TCTP is a central negative regulator of p53: it binds the p53 DNA-binding domain to block Bax transactivation (PMID:21795694) and competes with NUMB at the p53–MDM2 complex to promote MDM2-mediated p53 ubiquitination and degradation, with p53 reciprocally repressing TCTP transcription (PMID:22157679); this axis is required for cardiomyocyte survival in vivo, as cardiac p53 deletion rescues the lethal heart failure of fortilin heart-specific knockouts (PMID:34689154). It further restrains the ER-stress sensor IRE1α by directly inhibiting both its kinase and RNase activities (PMID:28550308), protects peroxiredoxin-1 from inactivating Mst1 phosphorylation to limit ROS damage (PMID:26726832), and stabilizes the survival factor CTNNA3 against phosphorylation-driven proteasomal degradation (PMID:39747445). TCTP also drives cell growth and proliferation by acting as a GEF for Rheb to activate TOR signaling (PMID:27151460), by interacting with the COP9 signalosome subunit CSN4 to regulate CUL1 neddylation and the G1/S transition (PMID:30695029), and by activating Wnt/β-catenin–TCF-4 signaling (PMID:24311645); its own abundance is controlled translationally by the PI3-K/Akt/mTORC1 pathway, including under DNA-damage stress where it promotes drug resistance (PMID:25936523, PMID:28143584). The protein is stabilized by MCL1, which acts as a chaperone for fortilin (PMID:12149273). A distinct enzymatic activity—NAD⁺-dependent RNA 2'-phosphotransferase that resolves internal RNA 2'-monophosphates—is encoded by Tpt1 orthologs in fungi and archaea and represents a separate, non-mammalian function of this locus family (PMID:30202863, PMID:30644400).

Mechanistic history

Synthesis pass · year-by-year structured walk · 32 steps
  1. 2001 High

    Established TPT1/fortilin as a bona fide anti-apoptotic protein, distinct from the known Bcl-2 and IAP families, defining a new cytoprotective factor.

    Evidence Overexpression, antisense depletion, and caspase-3 assays across HeLa, U2OS, and MCF-7 cells

    PMID:11598139

    Open questions at the time
    • Molecular target of caspase suppression not defined
    • Did not localize the protective step within the apoptotic cascade
  2. 2002 High

    Identified MCL1 as a binding partner that chaperones and stabilizes fortilin, linking its abundance to a known survival protein.

    Evidence Yeast two-hybrid, reciprocal co-IP, pulse-chase with the R21A binding mutant, and siRNA

    PMID:12149273

    Open questions at the time
    • Whether MCL1 binding contributes to anti-apoptotic activity beyond stabilization unresolved at this stage
    • Structural basis of the interaction not defined
  3. 2002 Medium

    Placed TCTP in a tumor-reversion/reprogramming pathway, showing its downregulation reverses the malignant phenotype.

    Evidence Differential expression, antisense/siRNA, and tumorigenicity assays relative to SIAH-1

    PMID:12399545

    Open questions at the time
    • Direct molecular link between TCTP and SIAH-1 not established
    • Mechanism of phenotypic reversion left undefined
  4. 2006 High

    Defined transcriptional control of TPT1 by CREB/ATF1 via proximal CRE sites, connecting cAMP/PKA signaling to TCTP synthesis.

    Evidence Reporter assays, EMSA/footprinting/supershift, promoter deletions, and forskolin stimulation

    PMID:16859841

    Open questions at the time
    • Physiological stimuli driving CRE-dependent expression in vivo not defined
    • Interplay with later-identified p53 repression not addressed
  5. 2007 High

    Showed fortilin is an intracellular Ca²⁺ scavenger whose N-terminal Ca²⁺ binding is required for protection against Ca²⁺-dependent apoptosis.

    Evidence Ca²⁺-overlay, flow dialysis, CD spectroscopy, E58A/E60A mutant, and thapsigargin death assays

    PMID:17705784

    Open questions at the time
    • Very low affinity (Kd ~10 mM) raises questions about which physiological Ca²⁺ pools are buffered
    • Connection to ER stress signaling not yet drawn
  6. 2007 Medium

    Implicated Tpt1 in pluripotency-gene activation, showing it can promote oct4/nanog transcription during somatic nuclear reprogramming.

    Evidence Oct4-region affinity purification, mass spectrometry, and transcript depletion/elevation in Xenopus oocyte nuclear transfer

    PMID:17442571

    Open questions at the time
    • Direct vs. indirect action on pluripotency promoters unresolved
    • Apparent conflict with later mouse data showing Oct4 repression
  7. 2008 High

    Provided structural and in vivo basis for anti-apoptosis: a Bax-like H2–H3 region inserts into mitochondria to block Bax dimerization, and loss is embryonically lethal.

    Evidence 2.0 Å crystal structure, H2–H3 mutagenesis, mitochondrial insertion/Bax dimerization assays, and Tctp-null mice

    PMID:18274553

    Open questions at the time
    • Stoichiometry and lipid requirements of membrane insertion not defined
    • Whether mitochondrial action is the principal cause of embryonic lethality not isolated
  8. 2008 Medium

    Connected TCTP to the mitotic spindle checkpoint through a microtubule-dependent interaction with the Chfr checkpoint protein.

    Evidence Yeast two-hybrid, endogenous co-IP, spindle colocalization, and microtubule depolymerization

    PMID:18504434

    Open questions at the time
    • Functional consequence of Chfr binding for checkpoint output not tested
    • Whether TCTP is a Chfr substrate or regulator unresolved
  9. 2008 Medium

    Identified fortilin as a druggable target: dihydroartemisinin binds it and triggers its ubiquitin-proteasome degradation, sensitizing cells to apoptosis.

    Evidence Binding, ubiquitination, pulse-chase, proteasome inhibition, and knockdown/overexpression DNA-fragmentation rescue

    PMID:18325342

    Open questions at the time
    • DHA binding site on fortilin not mapped
    • E3 ligase mediating DHA-induced ubiquitination not identified
  10. 2008 Low

    Linked fortilin to TGF-β signaling antagonism by promoting proteasomal degradation of the pro-apoptotic factor TSC-22.

    Evidence Yeast two-hybrid, knockdown/overexpression, apoptosis rescue, and degradation analysis

    PMID:18325344

    Open questions at the time
    • No in-cell co-IP confirming the direct interaction
    • Degradation mechanism (E3 ligase, ubiquitination site) not defined
  11. 2009 High

    Established fortilin as an inhibitor of BMP signaling required for neural development, integrating its survival role with embryonic patterning.

    Evidence Mouse knockout (lethal ~3.5 dpc), Xenopus gain/loss-of-function with BMP4 target readouts, and MEF siRNA

    PMID:19364479

    Open questions at the time
    • Molecular point of BMP-pathway inhibition not identified
    • Discrepancy in reported lethality timing versus earlier knockout not reconciled
  12. 2011 High

    Defined a direct anti-p53 mechanism: fortilin binds the p53 DNA-binding domain to block Bax transactivation and drive tumorigenesis.

    Evidence Co-IP, p53-binding-deficient mutant, Bax reporter assay, apoptosis assay, and xenografts

    PMID:21795694

    Open questions at the time
    • Whether binding affects other p53 targets beyond Bax not addressed
    • Structural details of the p53–fortilin interface not resolved
  13. 2011 High

    Showed TCTP promotes p53 degradation by competing with NUMB at the p53–MDM2 complex, establishing a reciprocal TCTP–p53 regulatory loop.

    Evidence Co-IP, ubiquitination assays, promoter reporters, Tctp+/- mice, and pharmacological inhibition

    PMID:22157679

    Open questions at the time
    • Relative contribution of direct p53 binding (#12) versus MDM2-competition pathway not quantified
    • How the two opposing transcriptional arms are balanced in vivo unclear
  14. 2012 Medium

    Demonstrated context-dependent control of Oct4: in mouse pluripotent cells TCTP binds the Sf1 site of the Oct4 promoter and represses it, contrasting with the Xenopus activation phenotype.

    Evidence Overexpression/knockdown, promoter reporter, and N-terminal (1–60) deletion mapping

    PMID:22281008

    Open questions at the time
    • Direct DNA binding vs. cofactor-mediated promoter occupancy not distinguished
    • Basis of opposite direction relative to #6 unresolved
  15. 2013 Medium

    Positioned TCTP as an upstream activator of Wnt/β-catenin–TCF-4 signaling driving glioma proliferation.

    Evidence Co-IP, TOPflash reporter, target-gene Western blots, TCF-4 shRNA rescue, and xenografts

    PMID:24311645

    Open questions at the time
    • Whether TCTP acts directly on the β-catenin/TCF-4 complex or upstream not defined
    • Link to the separately reported β-catenin stabilization mechanism not integrated
  16. 2015 High

    Established that TCTP protein levels are set translationally by PI3-K/Akt/mTORC1 acting on its 5'-TOP mRNA.

    Evidence Polysome profiling, mTOR/Akt inhibitors, TSC2 KO, eIF4E overexpression, and constitutively active 4E-BP1

    PMID:25936523

    Open questions at the time
    • Interplay between this translational control and CREB-dependent transcription not addressed
    • Physiological signals tuning TCTP translation in vivo not defined
  17. 2016 High

    Resolved the BH3-like mechanism: TCTP refolds into a helix in the Bcl-xL groove and uniquely activates rather than inhibits Bcl-xL.

    Evidence Crystal structure of the Bcl-xL–TCTP11-31 complex, reconstitution, hybrid-BH3 mutagenesis, and TCTP+/- mice

    PMID:26813996

    Open questions at the time
    • Mechanism by which groove occupancy activates rather than inhibits Bcl-xL not fully explained
    • Relationship to the mitochondrial Bax-inhibition mechanism not unified
  18. 2016 High

    Defined TCTP as a Rheb GEF that activates TOR-driven growth, with 14-3-3 proteins required for the TCTP–Rheb interaction.

    Evidence Drosophila genetic epistasis, co-IP, phospho-S6K/4E-BP blots, and cyclin E rescue

    PMID:27151460

    Open questions at the time
    • Whether mammalian TCTP retains Rheb-GEF activity not tested here
    • Relationship to TCTP being itself an mTORC1 translational target (#15) creates a feedback loop not dissected
  19. 2016 Medium

    Revealed a chromatin role: TCTP restrains the Brahma remodeler to silence transposons and stabilize heterochromatin.

    Evidence Drosophila Tctp/brm epistasis, transcriptome/transposon analysis, and su(var)3-9 regulation

    PMID:27687497

    Open questions at the time
    • Direct Tctp–Brm binding in mammals not shown
    • Mechanism linking Brm modulation to heterochromatin stability incomplete
  20. 2016 Medium

    Showed the TCTP–Mcl1 axis supports axonal mitochondrial function and projection growth in neurons.

    Evidence Xenopus morpholino knockdown, axonal-compartment co-IP, live imaging, and Mcl1 epistasis

    PMID:26903505

    Open questions at the time
    • Whether axonal effects are MCL1-stabilization–dependent or independent not resolved
    • Direct cause of mitochondrial dysfunction not pinpointed
  21. 2016 High

    Identified an antioxidant mechanism: fortilin stabilizes PRX1 and blocks its inactivating Mst1 phosphorylation, protecting against ROS-mediated liver damage.

    Evidence Co-IP, proteasome inhibition, Mst1 kinase assay, and liver-specific transgenic mice in an alcohol model

    PMID:26726832

    Open questions at the time
    • How fortilin shields the PRX1 phospho-site mechanistically not defined
    • Generalizability beyond liver tissue not established
  22. 2017 High

    Showed TCTP directly inhibits the ER stress sensor IRE1α, blocking both its kinase and RNase activities to prevent ER-stress apoptosis.

    Evidence Co-IP, in vitro kinase and RNase assays, cellular apoptosis assays, and whole-animal ER-stress model

    PMID:28550308

    Open questions at the time
    • Binding interface on the IRE1α cytoplasmic domain not mapped
    • Effect on the XBP1-splicing arm of the UPR not separately quantified
  23. 2017 Medium

    Linked TCTP translational upregulation to chemoresistance, showing mTORC1-driven TCTP induction protects colon cancer cells from DNA-damaging drugs.

    Evidence mTOR inhibitors, mRNA/protein dissociation, and siRNA sensitization to 5-FU/oxaliplatin

    PMID:28143584

    Open questions at the time
    • Downstream effector responsible for resistance not isolated
    • Whether p53 inhibition mediates the resistance not tested
  24. 2017 Medium

    Demonstrated TCTP preserves oocyte spindle dynamics, linking its mitotic-spindle association to reproductive aging and embryo competency.

    Evidence siRNA/mRNA injection, live spindle imaging, and fertilization/embryo-development assays in mouse oocytes

    PMID:28476647

    Open questions at the time
    • Molecular partner mediating spindle stabilization not identified
    • Relationship to the Chfr–spindle interaction (#8) not addressed
  25. 2018 High

    Characterized the distinct enzymatic Tpt1 activity—NAD⁺-dependent RNA 2'-phosphotransferase resolving internal RNA 2'-monophosphates—in fungal/archaeal orthologs.

    Evidence In vitro enzymatic assays with purified Tpt1 enzymes from diverse taxa and product characterization

    PMID:30202863

    Open questions at the time
    • This RNA-repair activity is not demonstrated for the mammalian anti-apoptotic protein
    • Endogenous RNA substrate in higher eukaryotes not defined
  26. 2019 High

    Provided the structural mechanism of Tpt1 2'-PO4 splice-junction recognition and RNA phospho-ADP-ribosylation.

    Evidence 1.4 Å crystal structure in a product-mimetic complex with ADP-ribose-1''-phosphate and pAp

    PMID:30644400

    Open questions at the time
    • Relevance to mammalian TCTP biology remains separate
    • Physiological substrate identity in most lineages unresolved
  27. 2019 Medium

    Connected TCTP to cell-cycle control through CSN4/COP9 signalosome interaction regulating CUL1 neddylation at G1/S, conserved across plants and flies.

    Evidence Cross-species genetic interaction (Arabidopsis, Drosophila) and CUL1 neddylation/cell-cycle assays

    PMID:30695029

    Open questions at the time
    • Direct biochemical effect of TCTP on COP9 deneddylase activity not measured
    • Human relevance not directly tested
  28. 2019 High

    Established a cardiac survival role: TCTP loss triggers Bnip3-dependent apoptotic/autophagic cardiomyocyte death with mPTP opening, and overexpression protects against doxorubicin cardiotoxicity.

    Evidence siRNA, cardiomyocyte-specific transgenic mice, mPTP assays, Bnip3 blots, and doxorubicin heart-failure model

    PMID:31320615

    Open questions at the time
    • Mechanism by which TCTP suppresses Bnip3 not defined
    • Relationship to the p53-dependent cardiac death pathway (#28) not unified
  29. 2020 Medium

    Showed TCTP promotes EMT and invasion partly by binding and stabilizing β-catenin and inducing uPA, integrating its Wnt and migratory functions.

    Evidence Stable overexpression/knockdown, migration/invasion assays, EMT-marker blots, TCTP–β-catenin co-IP, and uPA assay

    PMID:28958626 PMID:30881019

    Open questions at the time
    • Direct vs. indirect β-catenin stabilization mechanism not resolved
    • Whether p53 downregulation drives the EMT program not isolated
  30. 2020 Medium

    Identified DLC1 as a negative regulator of TCTP levels at focal adhesions, controlling Cdc42-driven migration independently of DLC1 RhoGAP activity.

    Evidence Co-IP, colocalization, siRNA, GAP-dead R718A mutant, Cdc42 activation, and migration assays

    PMID:33150340

    Open questions at the time
    • Mechanism by which DLC1 lowers TCTP (degradation vs. translation) not defined
    • Direct vs. complex-mediated interaction not resolved
  31. 2022 Medium

    Linked TCTP to tumor immune evasion via phospho-dependent Na,K-ATPase interaction activating EGFR-AKT-MCL-1/CXCL10 signaling.

    Evidence Transcriptomics, immune-refractory tumor models, DHA inhibition, co-IP, phosphorylation, and T-cell killing assays

    PMID:35440620

    Open questions at the time
    • Causal step from Na,K-ATPase binding to immune refractoriness not fully isolated
    • Whether extracellular/membrane TCTP mediates this not addressed
  32. 2025 High

    Defined a new survival mechanism: fortilin specifically binds CTNNA3 (not other catenins) and protects it from phosphorylation-driven ubiquitin-proteasome degradation to prevent apoptosis.

    Evidence Co-IP, PLA, MST, BLI, phospho-null/mimetic CTNNA3 mutants, proteasome inhibition, and apoptosis assays

    PMID:39747445

    Open questions at the time
    • Kinase phosphorylating CTNNA3 not identified
    • Tissue contexts where CTNNA3 protection is physiologically relevant not defined

Open questions

Synthesis pass · forward-looking unresolved questions
  • How TCTP's many parallel pro-survival and growth mechanisms are coordinated within a single cell — and whether the mammalian protein possesses any of the RNA 2'-phosphotransferase enzymatic activity of its fungal/archaeal orthologs — remains unresolved.
  • No integrated model ranks the relative in vivo contribution of the p53, Bcl-xL, IRE1α, Ca²⁺, and PRX1 pathways
  • Whether mammalian TCTP/fortilin has any catalytic RNA-repair role is untested
  • Structural basis of most protein-protein interfaces (p53, IRE1α, CSN4) unresolved

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0098772 molecular function regulator activity 5 GO:0140096 catalytic activity, acting on a protein 3 GO:0140098 catalytic activity, acting on RNA 2 GO:0003677 DNA binding 1 GO:0140313 molecular sequestering activity 1
Localization
GO:0005634 nucleus 2 GO:0005739 mitochondrion 2 GO:0005829 cytosol 2 GO:0005856 cytoskeleton 2 GO:0005783 endoplasmic reticulum 1
Pathway
R-HSA-5357801 Programmed Cell Death 4 R-HSA-162582 Signal Transduction 3 R-HSA-1640170 Cell Cycle 3 R-HSA-1643685 Disease 3 R-HSA-8953897 Cellular responses to stimuli 3
Partners
BCL2L1CTNNA3ERN1MCL1MDM2PRDX1RHEBTP53
Complex memberships
COP9 signalosome

Evidence

Reading pass · 34 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2001 Fortilin (TPT1/TCTP) overexpression in HeLa and U2OS cells prevents etoposide-induced apoptosis in a dose-dependent manner and inhibits caspase-3-like activity, establishing it as a novel antiapoptotic protein structurally distinct from Bcl-2 family members and IAPs. Antisense depletion of fortilin from MCF-7 cells caused massive cell death. Transient/stable overexpression, antisense depletion, fluorogenic caspase substrate assay, immunocytochemistry The Journal of biological chemistry High 11598139
2002 Fortilin (TPT1) physically interacts with MCL1 both in vitro and in vivo; MCL1 acts as a chaperone that stabilizes fortilin by protecting it from rapid degradation. The fortilin(R21A) point mutant lacking MCL1-binding has a significantly shorter half-life than wild-type fortilin. Yeast two-hybrid screening, co-immunoprecipitation, siRNA knockdown, pulse-chase experiment, confocal immunostaining, site-directed mutagenesis The Journal of biological chemistry High 12149273
2002 TCTP/TPT1 is the most strongly downregulated gene during tumor reversion; antisense cDNA or siRNA-mediated inhibition of TCTP expression suppresses the malignant phenotype and causes cellular reorganization similar to SIAH-1 overexpression, placing TCTP in a cellular reprogramming pathway. Differential gene expression analysis, Northern blot, quantitative PCR, antisense cDNA transfection, siRNA, phenotypic assays (tumorigenicity) Proceedings of the National Academy of Sciences of the United States of America Medium 12399545
2004 Fortilin and MCL1 protect cells from 5-FU-induced cytotoxicity independently of each other: when MCL1 is silenced by siRNA, fortilin retains cytoprotective activity, and vice versa. The fortilin–MCL1 interaction therefore augments, but is not required for, their individual antiapoptotic functions. siRNA-mediated gene silencing, cell viability assays in monoclonal and polyclonal U2OS populations, subcellular localization analysis The Journal of biological chemistry Medium 15262975
2006 Transcription of the human TPT1 gene is regulated through two conserved CRE sites in the proximal promoter; supershift assays identified CREB I and Fra II (CREB/ATF1/AP1 family) as the interacting transcription factors. cAMP signaling via PKA-dependent CREB phosphorylation stimulates TCTP synthesis. Reporter-gene assays, gelshift (EMSA), footprinting, supershift assays, promoter deletion analysis, forskolin/PMA stimulation Gene High 16859841
2007 Fortilin binds Ca²⁺ with a Kd of ~10 mM (N-terminal residues 1–72 required); Ca²⁺ binding induces a conformational change in fortilin. The double point mutant fortilin(E58A/E60A) lacks Ca²⁺-binding ability and fails to protect cells against thapsigargin-induced, Ca²⁺-dependent apoptosis, establishing fortilin as an intracellular Ca²⁺ scavenger. Ca²⁺-overlay assay, flow dialysis, CD spectropolarimetry, intracellular Ca²⁺ measurement, site-directed mutagenesis, cell death assays The Biochemical journal High 17705784
2007 Tpt1 in Xenopus oocytes activates transcription of oct4 and nanog upon nuclear transfer of somatic nuclei: depletion of tpt1 transcripts reduces oct4/nanog transcription, while elevation of tpt1 causes earlier activation of oct4 transcription. Protein isolation by binding to oct4 regulatory region, mass spectrometry identification, oocyte transcript depletion, nuclear transfer, mRNA quantification Current biology : CB Medium 17442571
2008 Crystal structure of human TCTP at 2.0 Å resolution reveals structural similarity between TCTP helices H2–H3 and Bax helices H5–H6. Site-directed mutagenesis of H2–H3 impairs TCTP's antiapoptotic function. TCTP inserts into the mitochondrial membrane and inhibits Bax dimerization. Tctp-null mice show increased spontaneous embryonic apoptosis and die between E6.5 and E9.5. X-ray crystallography (2.0 Å), site-directed mutagenesis, mitochondrial membrane insertion assay, Bax dimerization assay, Tctp knockout mice Cell death and differentiation High 18274553
2008 Chfr checkpoint protein physically interacts with endogenous TCTP (identified by yeast two-hybrid and confirmed by co-immunoprecipitation of endogenous proteins); both co-localize to the mitotic spindle. The Chfr–TCTP interaction is stable throughout the cell cycle but is diminished by complete microtubule depolymerization, suggesting TCTP participates in the mitotic spindle checkpoint. Yeast two-hybrid screen, endogenous co-immunoprecipitation, immunofluorescence localization, microtubule depolymerization experiments Oncogene Medium 18504434
2008 Dihydroartemisinin (DHA) binds human fortilin, increases its ubiquitination, shortens its half-life in a proteasome-dependent manner, and reduces cellular fortilin levels. DHA-induced DNA fragmentation is fortilin-dependent: fortilin-knockdown cells are less susceptible and fortilin-overexpressing cells are more susceptible to DHA-induced apoptosis. Binding assay, ubiquitination assay, pulse-chase (half-life measurement), proteasome inhibitor studies, siRNA knockdown, overexpression, DNA fragmentation assay FEBS letters Medium 18325342
2008 Fortilin interacts with TSC-22 (TGF-β stimulated clone-22) via yeast two-hybrid; fortilin overexpression reverses TSC-22-mediated apoptosis in ovarian carcinoma cells, and fortilin promotes proteasomal degradation of TSC-22. Yeast two-hybrid screening, siRNA knockdown, overexpression, apoptosis assays, protein degradation analysis FEBS letters Low 18325344
2009 Fortilin-null (fortilin⁻/⁻) mice are embryonically lethal around 3.5 dpc. In Xenopus, fortilin depletion compromises neural tissue formation, while overexpression induces partial double body axis and blocks BMP4-induced transcription of Vent1, Vent2, and Msx1. In mouse embryonic fibroblasts, fortilin siRNA depletion allows BMP4 to cause extensive DNA fragmentation and increased Msx2 expression, establishing fortilin as an inhibitor of the BMP signaling pathway. Targeted gene disruption in mice, Xenopus embryo injections (mRNA depletion/overexpression), siRNA in MEFs, BMP4 stimulation, reporter gene assays, DNA fragmentation Biochimica et biophysica acta High 19364479
2011 Fortilin binds specifically to the sequence-specific DNA-binding domain of p53, blocking p53-induced transcriptional activation of Bax. A double-point mutant of fortilin lacking p53 binding fails to inhibit p53-dependent apoptosis. Cells expressing wild-type fortilin (but not the p53-binding mutant) form large tumors in athymic mice. Co-immunoprecipitation, site-directed mutagenesis, reporter gene assay (Bax transcription), apoptosis assay, xenograft tumor assay The Journal of biological chemistry High 21795694
2011 TCTP promotes p53 degradation by competing with NUMB for binding to p53-MDM2 complexes; TCTP inhibits MDM2 auto-ubiquitination and promotes MDM2-mediated ubiquitination and degradation of p53. P53 reciprocally directly represses TCTP transcription. Tctp haploinsufficient mice are sensitized to p53-dependent apoptosis. Co-immunoprecipitation, ubiquitination assays, knockdown/overexpression, promoter reporter assays, Tctp+/- mouse model, pharmacological inhibition (sertraline/thioridazine) Nature medicine High 22157679
2013 TCTP enhances glioma cell proliferation through increased β-catenin binding to TCF-4 and elevated TOPflash transcription activity and Wnt/β-catenin target gene expression (c-Myc, cyclin D1). TCF-4 shRNA rescues the TCTP overexpression-induced proliferation, establishing TCTP as an upstream activator of Wnt/β-catenin signaling. Co-immunoprecipitation (TCTP/TCF-4/β-catenin), TOPflash/FOPflash reporter assay, shRNA knockdown, xenograft model, Western blot Neuro-oncology Medium 24311645
2015 TCTP mRNA translation is regulated through the PI3-K/Akt/mTORC1 signalling pathway. mTOR kinase inhibitors and Akt inhibitors block serum-induced increases in TCTP protein. TSC2 knockout derepresses TCTP translation under starvation. A constitutively active 4E-BP1 mutant inhibits TCTP mRNA translation, and eIF4E overexpression increases polysomal association of TCTP mRNA. Polysome profiling, mRNA quantification by RT-qPCR, mTOR/Akt inhibitors, TSC2 knockout cells, eIF4E overexpression, 4E-BP1 constitutively active mutant, Western blot Cellular signalling High 25936523
2016 TCTP contains a BH3-like domain that binds the BH3-groove of Bcl-xL. Crystal structure of a Bcl-xL deletion variant–TCTP11-31 complex at atomic resolution shows TCTP refolds into a helical conformation upon Bcl-xL binding. Unlike all other BH3-domain proteins (which inhibit Bcl-xL), TCTP activates the anti-apoptotic function of Bcl-xL. Replacing the non-conserved h1 of TCTP with that from Bax drastically increases affinity for Bcl-xL and changes biological properties. X-ray crystallography (Bcl-xL–TCTP complex), in vitro reconstitution, in vivo functional assays, TCTP+/- mouse model, mutagenesis (hybrid BH3) Scientific reports High 26813996
2016 Drosophila TCTP (Tctp) physically interacts with Rheb GTPase and acts as a guanine nucleotide exchange factor (GEF) for Rheb, activating TOR signalling for organ growth. 14-3-3 proteins physically interact with both Tctp and Rheb; knockdown of both 14-3-3 isoforms abolishes Tctp–Rheb binding, reduces phospho-S6K, phospho-4E-BP, and cyclin E, impairing tissue growth. Growth defects are suppressed by CycE overexpression. Genetic epistasis (Drosophila knockdown/synergy), co-immunoprecipitation, phospho-S6K/4E-BP Western blot, cyclin E rescue Nature communications High 27151460
2016 Drosophila Tctp binds the Brahma (Brm) chromatin remodeler and negatively modulates its activity. Tctp mutants show elevated transcription of a large gene set and transposons; brm mutations ameliorate these defects. Tctp also promotes stability of rDNA and pericentromeric heterochromatin by opposing Brm and regulating su(var)3-9 transcription. Genetic epistasis (Drosophila Tctp mutants + brm mutants), chromatin/transcription analysis, transposon assays Nature communications Medium 27687497
2016 Tctp interacts with Mcl1 in the axonal compartment of Xenopus retinal ganglion cells; Tctp deficiency results in stunted retinotectal projections with mitochondrial dysfunction and impaired axon extension. Mcl1 knockdown phenocopies Tctp deficiency, placing Tctp upstream of Mcl1-mediated pro-survival signalling in axon development. Morpholino-mediated knockdown in Xenopus, co-immunoprecipitation in axonal compartment, live imaging, mitochondrial dysfunction assays, genetic epistasis Development (Cambridge, England) Medium 26903505
2016 Fortilin physically interacts with peroxiredoxin-1 (PRX1), protects PRX1 from proteasome-mediated degradation, and prevents its inactivating phosphorylation by Mst1 kinase. Liver-specific fortilin overexpression in transgenic mice reduces PRX1 phosphorylation and enhances PRX1 peroxidase activity, protecting against alcohol-induced ROS-mediated liver damage. Co-immunoprecipitation, proteasome inhibitor assays, kinase (Mst1) phosphorylation assay, transgenic mouse liver overexpression, PRX1 activity assay, alcohol liver-damage model Scientific reports High 26726832
2017 TCTP mRNA translation is upregulated via the mTORC1 pathway in HCT116 colon cancer cells in response to the DNA-damaging drugs 5-FU and oxaliplatin; mTOR kinase inhibitors prevent this upregulation. TCTP knockdown sensitises HCT116 cells to cytotoxicity by both drugs, establishing TCTP as a contributor to drug resistance via translational regulation. Western blot, RT-qPCR, mTOR inhibitors, siRNA knockdown, RTCA system, MTS cell viability assay Cell communication and signaling : CCS Medium 28143584
2017 Fortilin directly interacts with the cytoplasmic domain of IRE1α (the ER stress sensor), inhibits both its kinase and endoribonuclease (RNase) activities, and protects cells and whole animals from ER stress-induced apoptosis. Co-immunoprecipitation, in vitro kinase assay, in vitro RNase assay, cellular apoptosis assays, whole-animal (in vivo) ER stress model Nature communications High 28550308
2018 RNA 2'-phosphotransferase Tpt1 (the enzymatic activity encoded by the TPT1/Tpt1 gene in fungi) catalyzes NAD⁺-dependent conversion of internal RNA 2'-monophosphate to 2'-OH via a two-step mechanism forming a 2'-phospho-ADP-ribosylated RNA intermediate. A subset of Tpt1 enzymes (e.g., Aeropyrum pernix Tpt1) also catalyze NAD⁺-dependent ADP-ribosylation of 5'-monophosphate RNA/DNA termini to create a 5'-phospho-ADP-ribosylated cap. In vitro enzymatic assay with purified Tpt1 enzymes from diverse taxa, NAD⁺ substrate studies, product characterization Nucleic acids research High 30202863
2019 Crystal structure of Tpt1 (1.4 Å) in a product-mimetic complex with ADP-ribose-1″-phosphate (in NAD⁺ site) and pAp (in RNA site) reveals the mechanism of 2'-PO4 RNA splice-junction recognition and RNA phospho-ADP-ribosylation. Evidence is provided that a bacterium has an endogenous phosphorylated substrate for Tpt1. X-ray crystallography (1.4 Å), product-mimetic complex, substrate binding analysis Nature communications High 30644400
2019 TCTP controls the G1/S transition by interacting with CSN4 (a subunit of the COP9 Signalosome); TCTP loss leads to increased fraction of deneddylated CUL1 (a substrate of the COP9 complex). This mechanism is conserved between Arabidopsis and Drosophila: dCSN4 or dTCTP knockdown in Drosophila similarly impairs cell proliferation and CUL1 neddylation. Genetic interaction studies (Arabidopsis and Drosophila), CUL1 neddylation assays, cell cycle analysis, knockdown of CSN4 and TCTP PLoS genetics Medium 30695029
2019 Cardiomyocyte-specific TCTP knockdown with siRNA induces apoptotic and autophagic cell death accompanied by mitochondrial permeability transition pore (mPTP) opening; Bnip3 mediates this TCTP-loss-induced death. Cardiomyocyte-specific TCTP overexpression in mice decreases susceptibility to doxorubicin-induced cardiac dysfunction with attenuated Bnip3 induction. siRNA knockdown, cardiomyocyte-specific transgenic overexpression, mPTP assay, Bnip3 Western blot, doxorubicin heart failure model in mice Cell death & disease High 31320615
2020 TCTP/fortilin promotes epithelial-mesenchymal transition (EMT): overexpression increases ZEB1, α-SMA, and invasiveness while decreasing E-cadherin and p53 expression in A549 lung adenocarcinoma cells, and knockdown has opposite effects. TCTP also interacts with β-catenin to stabilize it and promote nuclear localization, and induces urokinase plasminogen activator (uPA) to destabilize ECM. Stable lentiviral overexpression/knockdown, scratch and transwell migration/invasion assays, Western blot for EMT markers, co-immunoprecipitation (TCTP–β-catenin), uPA assay OncoTargets and therapy / Biochimica et biophysica acta. Molecular cell research Medium 28958626 30881019
2021 Heart-specific fortilin knockout mice (fortilinKO-heart) die by 9 weeks with extensive cardiomyocyte apoptosis and severe heart failure; hearts show drastic upregulation of p53 target genes. Additional heart-specific p53 deletion in fortilinKO-heart mice extends lifespan from 9 to 18 weeks by mitigating cardiomyocyte apoptosis, establishing fortilin as a cardiac p53 inhibitor in vivo. Cardiomyocyte-specific conditional knockout (fortilinKO-heart), double knockout (fortilinKO-heart × p53KO-heart), cardiac phenotyping, p53 target gene expression, TUNEL/caspase apoptosis assays Cell death discovery High 34689154
2025 Fortilin specifically interacts with CTNNA3 (α-T-catenin) but not with CTNNA1, CTNNA2, or CTNNB. Fortilin silencing promotes phosphorylation of CTNNA3, leading to its ubiquitination and proteasome-mediated degradation. CTNNA3 knockdown causes 293T cells to undergo apoptosis, placing fortilin as a guardian of CTNNA3 stability and cell survival. Co-immunoprecipitation Western blot, proximity ligation assay, microscale thermophoresis, biolayer interferometry, siRNA knockdown, phospho-null and phospho-mimetic CTNNA3 mutants, proteasome inhibitor assays Communications biology High 39747445
2017 TCTP activates the EGFR-AKT-MCL-1/CXCL10 pathway via phosphorylation-dependent interaction with Na,K-ATPase, conferring immune-refractory phenotypes (decreased T cell trafficking and resistance to CTL-mediated killing) in tumor cells. Transcriptome analysis, immune-refractory tumor models, pharmacological inhibition (DHA), co-immunoprecipitation (TCTP–Na,K-ATPase), phosphorylation assays, T cell killing assays Nature communications Medium 35440620
2012 TCTP overexpression in mouse pluripotent P19 and ES cells downregulates Oct4 transcription; the N-terminal 1–60 aa of TCTP are required for this suppression. TCTP binds the Sf1 site of the Oct4 promoter, and siRNA knockdown of TCTP increases Oct4 expression. Overexpression, siRNA knockdown, promoter reporter assay, N-terminal deletion analysis, Oct4 mRNA/protein quantification BMB reports Medium 22281008
2017 TCTP regulates spindle dynamics in mouse oocytes: TCTP knockdown accelerates reduction of spindle dynamics during postovulatory aging, causing aging-related deterioration of oocyte quality, whereas TCTP overexpression preserves spindle dynamics and prevents aging-associated abnormalities, improving fertilization competency and embryo development. siRNA knockdown, mRNA overexpression injection, live spindle imaging (spindle dynamics), fertilization and embryo development assays in mouse oocytes Biochimica et biophysica acta. Molecular cell research Medium 28476647
2020 DLC1 and TCTP co-localize in focal adhesions and form a protein complex; DLC1 negatively regulates TCTP levels in a RhoGAP-independent manner (both WT and GAP-dead R718A mutant reduce TCTP). Depletion of DLC1 increases TCTP expression and elevates Cdc42 and downstream JNK/NF-κB and N-WASP signaling, promoting cancer cell migration. Co-immunoprecipitation, colocalization (immunofluorescence), siRNA depletion, GFP-DLC1 WT and GAP-dead mutant transfection, Cdc42 activation assay, migration assays Food & function Medium 33150340

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2004 The translationally controlled tumour protein (TCTP). The international journal of biochemistry & cell biology 343 14687915
2001 Characterization of fortilin, a novel antiapoptotic protein. The Journal of biological chemistry 233 11598139
2002 Biological models and genes of tumor reversion: cellular reprogramming through tpt1/TCTP and SIAH-1. Proceedings of the National Academy of Sciences of the United States of America 227 12399545
2011 Reciprocal repression between P53 and TCTP. Nature medicine 189 22157679
2008 TCTP protects from apoptotic cell death by antagonizing bax function. Cell death and differentiation 167 18274553
2002 Physical and functional interaction between myeloid cell leukemia 1 protein (MCL1) and Fortilin. The potential role of MCL1 as a fortilin chaperone. The Journal of biological chemistry 133 12149273
2012 TPT1/ TCTP-regulated pathways in phenotypic reprogramming. Trends in cell biology 99 23122550
2014 TCTP as therapeutic target in cancers. Cancer treatment reviews 88 24650927
2007 Tpt1 activates transcription of oct4 and nanog in transplanted somatic nuclei. Current biology : CB 86 17442571
2012 Targeting TCTP as a new therapeutic strategy in castration-resistant prostate cancer. Molecular therapy : the journal of the American Society of Gene Therapy 72 22893039
2010 Shrimp Pm-fortilin inhibits the expression of early and late genes of white spot syndrome virus (WSSV) in an insect cell model. Developmental and comparative immunology 72 21130805
2018 Long non-coding RNA TPT1-AS1 promotes cell growth and metastasis in cervical cancer via acting AS a sponge for miR-324-5p. Journal of experimental & clinical cancer research : CR 70 30045766
2017 Fortilin binds IRE1α and prevents ER stress from signaling apoptotic cell death. Nature communications 66 28550308
2013 TCTP promotes glioma cell proliferation in vitro and in vivo via enhanced β-catenin/TCF-4 transcription. Neuro-oncology 61 24311645
2017 Dihydroartemisinin inhibits TCTP-dependent metastasis in gallbladder cancer. Journal of experimental & clinical cancer research : CR 60 28506239
2009 Gene silencing of translationally controlled tumor protein (TCTP) by siRNA inhibits cell growth and induces apoptosis of human prostate cancer cells. International journal of oncology 60 19360337
2007 Fortilin binds Ca2+ and blocks Ca2+-dependent apoptosis in vivo. The Biochemical journal 59 17705784
2012 Biological effects of Mammalian translationally controlled tumor protein (TCTP) on cell death, proliferation, and tumorigenesis. Biochemistry research international 58 22675633
2004 Antiapoptotic protein partners fortilin and MCL1 independently protect cells from 5-fluorouracil-induced cytotoxicity. The Journal of biological chemistry 58 15262975
2015 Phospho-TCTP as a therapeutic target of Dihydroartemisinin for aggressive breast cancer cells. Oncotarget 56 25779659
2019 LncRNA TPT1-AS1 promotes tumorigenesis and metastasis in epithelial ovarian cancer by inducing TPT1 expression. Cancer science 54 30941821
2017 Lipid-oligonucleotide conjugates improve cellular uptake and efficiency of TCTP-antisense in castration-resistant prostate cancer. Journal of controlled release : official journal of the Controlled Release Society 52 28472637
2011 Expression of Wnt9, TCTP, and Bmp1/Tll in sea cucumber visceral regeneration. Gene expression patterns : GEP 51 22079950
2008 Chfr interacts and colocalizes with TCTP to the mitotic spindle. Oncogene 51 18504434
2017 The Translational Controlled Tumour Protein TCTP: Biological Functions and Regulation. Results and problems in cell differentiation 50 29149404
2020 MiR-216a-5p inhibits tumorigenesis in Pancreatic Cancer by targeting TPT1/mTORC1 and is mediated by LINC01133. International journal of biological sciences 45 32792860
2017 MicroRNA-216b-5p Functions as a Tumor-suppressive RNA by Targeting TPT1 in Pancreatic Cancer Cells. Journal of Cancer 45 28928875
2020 Dysregulation of TCTP in Biological Processes and Diseases. Cells 44 32645936
2008 Human fortilin is a molecular target of dihydroartemisinin. FEBS letters 44 18325342
2018 NAD+-dependent synthesis of a 5'-phospho-ADP-ribosylated RNA/DNA cap by RNA 2'-phosphotransferase Tpt1. Nucleic acids research 42 30202863
2017 Translationally controlled tumour protein TCTP is induced early in human colorectal tumours and contributes to the resistance of HCT116 colon cancer cells to 5-FU and oxaliplatin. Cell communication and signaling : CCS 42 28143584
2013 The effect of translationally controlled tumour protein (TCTP) on programmed cell death in plants. BMC plant biology 41 24040826
2020 Long non-coding RNA TPT1-AS1 promotes angiogenesis and metastasis of colorectal cancer through TPT1-AS1/NF90/VEGFA signaling pathway. Aging 40 32248186
2016 TCTP contains a BH3-like domain, which instead of inhibiting, activates Bcl-xL. Scientific reports 40 26813996
2012 TCTP in development and cancer. Biochemistry research international 40 22649730
2008 The role of Pm-fortilin in protecting shrimp from white spot syndrome virus (WSSV) infection. Fish & shellfish immunology 39 18793729
2018 LncRNA LINC01446 promotes glioblastoma progression by modulating miR-489-3p/TPT1 axis. Biochemical and biophysical research communications 38 30029885
2010 Translationally controlled tumour protein (TCTP) is a novel glucose-regulated protein that is important for survival of pancreatic beta cells. Diabetologia 38 21063673
2016 14-3-3 proteins regulate Tctp-Rheb interaction for organ growth in Drosophila. Nature communications 37 27151460
2015 Growth-factor dependent expression of the translationally controlled tumour protein TCTP is regulated through the PI3-K/Akt/mTORC1 signalling pathway. Cellular signalling 37 25936523
2019 circOMA1-Mediated miR-145-5p Suppresses Tumor Growth of Nonfunctioning Pituitary Adenomas by Targeting TPT1. The Journal of clinical endocrinology and metabolism 36 30721952
2013 TCTP overexpression is associated with the development and progression of glioma. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 36 23749504
2007 Annetocin and TCTP expressions in the earthworm Eisenia fetida exposed to PAHs in artificial soil. Ecotoxicology and environmental safety 35 18096229
2011 Physical and functional antagonism between tumor suppressor protein p53 and fortilin, an anti-apoptotic protein. The Journal of biological chemistry 32 21795694
2018 Tumor suppressor miR-145-5p sensitizes prolactinoma to bromocriptine by downregulating TPT1. Journal of endocrinological investigation 31 30370446
2015 Expression and clinical role of TCTP in epithelial ovarian cancer. Journal of molecular histology 31 25564355
2008 Messenger RNA expression of translationally controlled tumor protein (TCTP) in liver regeneration and cancer. Anticancer research 31 18630514
2016 Fortilin potentiates the peroxidase activity of Peroxiredoxin-1 and protects against alcohol-induced liver damage in mice. Scientific reports 30 26726832
2016 Tumor protein Tctp regulates axon development in the embryonic visual system. Development (Cambridge, England) 30 26903505
2009 Embryonic lethality of fortilin-null mutant mice by BMP-pathway overactivation. Biochimica et biophysica acta 30 19364479
2019 Long noncoding RNA TPT1-AS1 downregulates the microRNA-770-5p expression to inhibit glioma cell autophagy and promote proliferation through STMN1 upregulation. Journal of cellular physiology 29 31637705
2017 TCTP as a therapeutic target in melanoma treatment. British journal of cancer 28 28751755
2020 Combination of dihydroartemisinin and resveratrol effectively inhibits cancer cell migration via regulation of the DLC1/TCTP/Cdc42 pathway. Food & function 27 33150340
2019 Structure of tRNA splicing enzyme Tpt1 illuminates the mechanism of RNA 2'-PO4 recognition and ADP-ribosylation. Nature communications 27 30644400
2013 TCTP is an androgen-regulated gene implicated in prostate cancer. PloS one 25 23894469
2013 The response profiles of HSPA12A and TCTP from Mytilus galloprovincialis to pathogen and cadmium challenge. Fish & shellfish immunology 24 23643947
2008 Interaction between fortilin and transforming growth factor-beta stimulated clone-22 (TSC-22) prevents apoptosis via the destabilization of TSC-22. FEBS letters 24 18325344
2003 Adenoviral gene transfer of fortilin attenuates neointima formation through suppression of vascular smooth muscle cell proliferation and migration. Circulation 24 12515750
2022 Positive feedback regulation of lncRNA TPT1-AS1 and ITGB3 promotes cell growth and metastasis in pancreatic cancer. Cancer science 23 35534983
2019 TCTP and CSN4 control cell cycle progression and development by regulating CULLIN1 neddylation in plants and animals. PLoS genetics 22 30695029
2016 Antagonistic roles of Drosophila Tctp and Brahma in chromatin remodelling and stabilizing repeated sequences. Nature communications 21 27687497
2006 Expression of the human TPT1 gene coding for translationally controlled tumor protein (TCTP) is regulated by CREB transcription factors. Gene 21 16859841
2005 Evolution and expression of translationally controlled tumour protein (TCTP) of fish. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 21 16006164
2003 Genomic organization and expression of mouse Tpt1 gene. Genomics 21 12782126
2019 MiR-204 suppresses cell proliferation and promotes apoptosis in ovarian granulosa cells via targeting TPT1 in polycystic ovary syndrome. Biochemistry and cell biology = Biochimie et biologie cellulaire 20 31460785
2013 Fortilin reduces apoptosis in macrophages and promotes atherosclerosis. American journal of physiology. Heart and circulatory physiology 20 24043250
2011 The Pot1a-associated proteins Tpt1 and Pat1 coordinate telomere protection and length regulation in Tetrahymena. Molecular biology of the cell 20 21900503
2025 Fortilin binds CTNNA3 and protects it against phosphorylation, ubiquitination, and proteasomal degradation to guard cells against apoptosis. Communications biology 19 39747445
2020 LncRNA TPT1-AS1 Sponges miR-23a-5p in Glioblastoma to Promote Cancer Cell Proliferation. Cancer biotherapy & radiopharmaceuticals 19 32783743
2012 Dimerization of TCTP and its clinical implications for allergy. Biochimie 19 23104268
2007 PAI-1 induces cell detachment, downregulates nucleophosmin (B23) and fortilin (TCTP) in LnCAP prostate cancer cells. International journal of molecular medicine 19 17549383
2021 Long non-coding RNA TPT1-AS1 sensitizes breast cancer cell to paclitaxel and inhibits cell proliferation by miR-3156-5p/caspase 2 axis. Human cell 18 33999360
2021 Fortilin inhibits p53, halts cardiomyocyte apoptosis, and protects the heart against heart failure. Cell death discovery 18 34689154
2020 TCTP is Essential for Cell Proliferation and Survival during CNS Development. Cells 18 31935927
2017 Insights into the role and regulation of TCTP in skeletal muscle. Oncotarget 18 27813490
2014 Elevation of serum fortilin levels is specific for apoptosis and signifies cell death in vivo. BBA clinical 17 25558447
2020 Guizhi Fuling pills inhibit the proliferation, migration and invasion of human cutaneous malignant melanoma cells by regulating the molecular axis of LncRNA TPT1-AS1 / miR-671-5p. Cellular and molecular biology (Noisy-le-Grand, France) 16 33040829
2019 Translationally controlled tumor protein (TCTP) plays a pivotal role in cardiomyocyte survival through a Bnip3-dependent mechanism. Cell death & disease 16 31320615
2018 Some Biological Consequences of the Inhibition of Na,K-ATPase by Translationally Controlled Tumor Protein (TCTP). International journal of molecular sciences 16 29867020
2018 Long noncoding RNA lncBRM promotes proliferation and invasion of colorectal cancer by sponging miR-204-3p and upregulating TPT1. Biochemical and biophysical research communications 16 30563768
2017 Targeting TCTP with Sertraline and Thioridazine in Cancer Treatment. Results and problems in cell differentiation 16 29149415
2022 Targeting TCTP sensitizes tumor to T cell-mediated therapy by reversing immune-refractory phenotypes. Nature communications 15 35440620
2020 Flexible loop and helix 2 domains of TCTP are the functional domains of dimerized TCTP. Scientific reports 15 31932619
2017 TCTP regulates spindle assembly during postovulatory aging and prevents deterioration in mouse oocyte quality. Biochimica et biophysica acta. Molecular cell research 15 28476647
2017 Fortilin: A Potential Target for the Prevention and Treatment of Human Diseases. Advances in clinical chemistry 15 28939212
2017 Role of TCTP for Cellular Differentiation and Cancer Therapy. Results and problems in cell differentiation 15 29149414
2007 Induction of translationally controlled tumor protein (TCTP) by transcriptional and post-transcriptional mechanisms. The FEBS journal 15 17894822
2021 Long noncoding RNA TPT1-AS1 promotes the progression and metastasis of colorectal cancer by upregulating the TPT1-mediated FAK and JAK-STAT3 signalling pathways. Aging 14 33428595
2020 The permissive role of TCTP in PM2.5/NNK-induced epithelial-mesenchymal transition in lung cells. Journal of translational medicine 14 32046740
2017 Translationally controlled tumor protein (TCTP) is required for TGF-β1 induced epithelial to mesenchymal transition and influences cytoskeletal reorganization. Biochimica et biophysica acta. Molecular cell research 14 28958626
2016 Translationally controlled tumour protein (TCTP) from tomato and Nicotiana benthamiana is necessary for successful infection by a potyvirus. Molecular plant pathology 14 27159273
2012 Translationally controlled tumor protein (TCTP) downregulates Oct4 expression in mouse pluripotent cells. BMB reports 14 22281008
2007 To cease or to proliferate: new insights into TCTP function from a Drosophila study. Cell adhesion & migration 14 19262129
2021 Knockdown of TPT1-AS1 inhibits cell proliferation, cell cycle G1/S transition, and epithelial-mesenchymal transition in gastric cancer. Bosnian journal of basic medical sciences 13 32156253
2021 lncRNA TPT1‑AS1 knockdown inhibits liver cancer cell proliferation, migration and invasion. Molecular medicine reports 13 34498708
2017 Upregulation of TCTP is associated with cholangiocarcinoma progression and metastasis. Oncology letters 13 29113234
2015 TCTP Expression After Rat Spinal Cord Injury: Implications for Astrocyte Proliferation and Migration. Journal of molecular neuroscience : MN 13 26266488
2011 Expression of translationally controlled tumor protein (TCTP) in the uterus of mice of early pregnancy and its possible significance during embryo implantation. Human reproduction (Oxford, England) 13 21865235
2021 Role of TCTP in Cell Biological and Disease Processes. Cells 12 34571939
2019 TCTP promotes epithelial-mesenchymal transition in lung adenocarcinoma. OncoTargets and therapy 12 30881019

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