Affinage

RPL27

Large ribosomal subunit protein eL27 · UniProt P61353

Length
136 aa
Mass
15.8 kDa
Annotated
2026-06-10
54 papers in source corpus 15 papers cited in narrative 15 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

RPL27 is a conserved component of the large ribosomal subunit that sits at the base of the central protuberance on the interface side of the particle, in direct contact with 23S/large-subunit rRNA near the peptidyl transferase center (PTC) (PMID:3123891, PMID:6170935, PMID:3278299). Its flexible N-terminus protrudes toward the catalytic site and positions the acceptor ends of tRNA substrates: truncation of the first few N-terminal residues impairs A-site tRNA placement and peptidyl transferase activity in the bacterial ortholog, and single-molecule measurements identify residue K4 as a key determinant of peptidyl-tRNA stabilization at the P site (PMID:16285924, PMID:22930421). Despite this proximity to the active site, fast-kinetics analysis shows that peptide bond formation and peptidyl-tRNA hydrolysis proceed independently of L27, establishing that its primary contributions are to subunit association and substrate positioning rather than to catalysis itself, consistent with the ribosome-as-ribozyme model (PMID:26475831). The role of L27 in assembly is genetically separable from its role in translation (PMID:11673426, PMID:9677420), and the mammalian protein is functionally interchangeable with the eukaryotic ribosomal core (PMID:2643099). In humans, loss-of-function mutations in RPL27 cause Diamond-Blackfan anaemia by impairing pre-rRNA processing and erythropoiesis (PMID:25424902). RPL27 silencing in colorectal cancer cells suppresses proliferation, arrests the cell cycle, and induces apoptosis through downregulation of PLK1 and G2/M regulators (PMID:37387446).

Mechanistic history

Synthesis pass · year-by-year structured walk · 15 steps
  1. 1981 Medium

    Established the physical neighborhood of L27 within the large subunit by mapping it directly onto rRNA, the first step toward understanding where it acts.

    Evidence RNA-protein cross-linking (2-iminothiolane + UV) in E. coli 50S subunits, localizing L27 contacts to 23S rRNA positions 2332-2337

    PMID:3278299 PMID:6170935

    Open questions at the time
    • Cross-link mapping gives proximity, not functional consequence
    • No structural model of the contact at this stage
  2. 1987 Medium

    Independently positioned L27 at the base of the central protuberance near the PTC, corroborating the rRNA cross-linking and locating it at the subunit interface.

    Evidence Immuno-electron microscopy and 50S reconstitution with heterologous B. subtilis L27

    PMID:3123891

    Open questions at the time
    • Low resolution localization
    • Does not establish a catalytic or assembly role
  3. 1988 Medium

    Refined the rRNA cross-link site, reinforcing L27 proximity to the peptidyl transferase region.

    Evidence Independent RNA-protein cross-linking (2-iminothiolane + UV) with antibody affinity chromatography, refining the site to 23S positions 2320-2323

    PMID:3278299

    Open questions at the time
    • Replication of localization but no functional assignment
    • Method-dependent site mapping
  4. 1989 Medium

    Showed the mammalian ortholog is functionally compatible with the eukaryotic ribosome, validating cross-kingdom inference about RPL27 function.

    Evidence Heterologous complementation of yeast L29 deletion by mouse L27', with cycloheximide-resistance and growth assays

    PMID:2643099

    Open questions at the time
    • Functional substitution does not reveal mechanism
    • Yeast L29 is preferentially assembled when both present
  5. 1998 High

    Defined the functional consequences of losing L27, linking it to subunit assembly, peptidyl transferase activity, and specifically A-site tRNA binding.

    Evidence rpmA knockout in E. coli with sedimentation assembly analysis, peptidyl transferase assays, and A-/P-site tRNA binding assays

    PMID:9677420

    Open questions at the time
    • Whether the PTC defect is direct catalysis or substrate positioning is unresolved
    • Assembly and translation roles not yet separated
  6. 2001 Medium

    Separated the assembly role of L27 from its translation role by showing a heterologous ortholog restores function but not assembly.

    Evidence Complementation of E. coli L27 deletion with A. aeolicus L27, sedimentation, CD and NMR spectroscopy

    PMID:11673426

    Open questions at the time
    • Molecular basis of assembly defect not defined
    • Single heterologous protein tested
  7. 2004 High

    Provided an atomic-resolution fold for L27, revealing an all-beta architecture with a positively charged RNA-binding surface consistent with PTC contact.

    Evidence X-ray crystallography (MAD phasing) of T. thermophilus L27 at 2.8 Å

    PMID:15340170

    Open questions at the time
    • Isolated protein structure, not in ribosome context
    • N-terminal flexible region not resolved functionally
  8. 2005 High

    Pinpointed the flexible N-terminus as the functional element reaching into the PTC and positioning tRNA substrate, refining the mechanism from 'L27 is near the PTC' to 'L27's N-terminus orients the tRNA acceptor end'.

    Evidence N-terminal truncation mutagenesis, growth and peptidyl transferase assays, photoreactive tRNA cross-linking at the P site

    PMID:16285924

    Open questions at the time
    • Does not distinguish positioning from direct catalytic contribution
    • Residue-level determinants not yet mapped
  9. 2008 Low

    Computationally predicted that L27 contributes to substrate binding (via the A76 phosphate of A-site tRNA) rather than catalysis, anticipating the ribozyme-consistent view.

    Evidence Molecular dynamics / free energy perturbation simulations of the PTC reaction in T. thermophilus

    PMID:18393533

    Open questions at the time
    • Computational prediction with no experimental validation in the study
    • Predicted puromycin pH effect untested here
  10. 2012 Medium

    Demonstrated at single-molecule resolution that L27 stabilizes peptidyl-tRNA at the P site and identified K4 as a key residue, assigning a specific dynamic role to the N-terminus.

    Evidence Single-molecule FRET of tRNA dynamics with L27 N-terminal truncation and K4 point mutants

    PMID:22930421

    Open questions at the time
    • Single lab
    • Effect on overall translation rate not measured here
  11. 2015 High

    Resolved the long-standing catalysis question by showing peptide bond formation and termination hydrolysis are independent of L27, reassigning its primary role to subunit association and substrate positioning.

    Evidence Rapid stopped-flow kinetics, translation of natural mRNAs, pH-dependence measurements, and L27 deletion strain

    PMID:26475831

    Open questions at the time
    • Mechanism of how L27 promotes subunit association not fully defined
    • Bacterial system; eukaryotic specifics not directly addressed
  12. 2014 High

    Connected RPL27 to human disease, showing loss-of-function causes Diamond-Blackfan anaemia via impaired pre-rRNA processing and erythropoiesis.

    Evidence Whole-exome sequencing, siRNA knockdown with pre-rRNA processing analysis, and zebrafish mutant/morphant models with erythroid and developmental readouts

    PMID:25424902

    Open questions at the time
    • Tissue-selective sensitivity of erythropoiesis not mechanistically explained
    • Link between pre-rRNA processing defect and erythroid failure not detailed
  13. 2014 Medium

    Revealed that in some bacteria L27 requires post-translational N-terminal processing for function, identifying the Prp cysteine protease as the maturation enzyme.

    Evidence Proteomics, biochemical characterization of Prp protease activity, and sequence comparison of mature vs precursor L27 in S. aureus

    PMID:25388641

    Open questions at the time
    • Relevance to eukaryotic RPL27 not established
    • Functional consequence of uncleaved extension not quantified
  14. 2023 Medium

    Placed RPL27 upstream of a PLK1-dependent proliferation and stemness axis in cancer, extending its role beyond housekeeping translation.

    Evidence siRNA knockdown in colorectal cancer lines with proliferation/cell-cycle/apoptosis assays, xenografts, RNA-seq, western blot of PLK1 and G2/M regulators, and sphere-forming assays

    PMID:37387446

    Open questions at the time
    • Pathway placement based on protein-level correlation, not direct epistasis
    • Whether the effect is ribosome-dependent or extra-ribosomal is unresolved
  15. 2025 Medium

    Defined the Prp-L27 protease-substrate interaction at residue resolution and showed processing is required for optimal growth, while a redundant protease can substitute in some species.

    Evidence In vitro cleavage assays, PrpC34S and L27 F12A mutagenesis, in vivo overexpression and Δprp growth assays in S. pneumoniae (preprint)

    PMID:40766419

    Open questions at the time
    • Preprint, not yet peer-reviewed
    • Identity of redundant protease not determined
    • No eukaryotic counterpart addressed

Open questions

Synthesis pass · forward-looking unresolved questions
  • How RPL27 mechanistically couples its ribosomal function to the PLK1 proliferation/stemness axis, and why erythroid progenitors are selectively vulnerable to RPL27 loss in humans, remain open.
  • No direct epistasis linking RPL27 to PLK1
  • No mechanism for tissue-selective DBA phenotype
  • Extra-ribosomal functions of human RPL27 uncharacterized

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0003723 RNA binding 3 GO:0005198 structural molecule activity 3
Localization
GO:0005840 ribosome 3 GO:0005730 nucleolus 1
Pathway
R-HSA-392499 Metabolism of proteins 2 R-HSA-8953854 Metabolism of RNA 1
Partners
PRP
Complex memberships
60S/50S large ribosomal subunit

Evidence

Reading pass · 15 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1998 Deletion of the E. coli rpmA gene (encoding ribosomal protein L27) causes slow growth, cold- and temperature-sensitivity, accumulation of a 40S precursor to the 50S subunit deficient in proteins L16, L20, L21, and L27, and a 3-4-fold reduction in peptidyl transferase activity of 70S ribosomes. L27-lacking ribosomes are impaired in A-site tRNA binding (Phe-tRNAPhe) but not P-site binding, indicating L27 contributes to peptide bond formation by facilitating proper placement of the A-site tRNA acceptor end at the peptidyl transferase center. Gene deletion (rpmA knockout), ribosome assembly analysis by sedimentation, peptidyl transferase activity assay, tRNA binding assays (A-site and P-site) The Journal of biological chemistry High 9677420
2005 The N-terminal sequence of bacterial ribosomal protein L27 protrudes onto the interface of the 50S subunit and reaches the peptidyl transferase active site. Truncation of as few as 3 N-terminal amino acids reduces growth rate, impairs peptidyl transferase activity, and sharply decreases cross-linking of L27 to the 3' end of a photoreactive tRNA at the P site, demonstrating the flexible N-terminus is required for correct tRNA substrate positioning at the catalytic site. N-terminal truncation mutagenesis, growth rate assays, peptidyl transferase activity assays, photoreactive tRNA cross-linking at P site Molecular cell High 16285924
1987 Immuno-electron microscopy using antibodies specific for E. coli L27 and reconstitution of 50S subunits from L27-lacking mutants with B. subtilis L27 localized ribosomal protein L27 at the base of the central protuberance on the interface side of the 50S particle, in proximity to the peptidyl transferase centre. Immuno-electron microscopy, 50S subunit reconstitution with heterologous L27 Molecular & general genetics : MGG Medium 3123891
1981 RNA-protein cross-linking with 2-iminothiolane followed by UV irradiation in E. coli 50S subunits localized L27 cross-linking sites to positions 2332-2337 of 23S RNA, placing L27 in direct contact with the 23S rRNA near the peptidyl transferase region. RNA-protein cross-linking (2-iminothiolane + UV), RNA fragment analysis Nucleic acids research Medium 3278299 6170935
1988 A second independent RNA-protein cross-linking study confirmed L27 contact with 23S RNA, refining the cross-link site to positions 2320-2323, further supporting L27 proximity to the peptidyl transferase center. RNA-protein cross-linking (2-iminothiolane + UV), affinity chromatography with antibodies, RNA fragment analysis Nucleic acids research Medium 3278299
2004 Crystal structure of ribosomal protein L27 from Thermus thermophilus HB8 determined at 2.8 Å resolution by multiwavelength anomalous dispersion. The structure reveals an all-beta-sheet fold consisting of two sets of four-stranded beta-sheets around a hydrophobic core, with a highly positive surface charge consistent with RNA binding at the peptidyl transferase center. X-ray crystallography (MAD phasing), 2.8 Å resolution Protein science : a publication of the Protein Society High 15340170
2008 Computer simulations of the peptidyl transfer reaction in T. thermophilus ribosomes predict that deletion of L27 causes only a minor reduction in the rate of peptide bond formation, consistent with the ribozyme view. The N-terminus of L27 is predicted to interact with the A76 phosphate group of A-site tRNA, explaining the observed impairment of A-site substrate binding in L27-lacking ribosomes. For puromycin (which lacks the A76 phosphate), deprotonation of the L27 N-terminal amine is predicted to accelerate the reaction, potentially explaining pH dependence differences. Molecular dynamics / free energy perturbation simulations of the PTC reaction Biochemistry Low 18393533
2012 Single-molecule FRET measurements of tRNA dynamics at the peptidyl transfer center show that removing the first three N-terminal residues of L27 or mutating residue K4 reduces stable peptidyl tRNA formation after translocation, demonstrating that L27 stabilizes peptidyl tRNA at the P site and that K4 is a key residue for this stabilization. Single-molecule FRET (smFRET), L27 N-terminal truncation and point mutagenesis (K4) Protein science : a publication of the Protein Society Medium 22930421
2015 Fast kinetics experiments show that the rate of peptide-bond formation at physiological pH with aminoacyl-tRNA or puromycin is independent of the presence of L27; translation of natural mRNAs is only marginally affected in the absence of L27; and the pH dependence of the puromycin reaction is unaltered without L27, indicating the L27 N-terminal alpha-amine is not the ionizing group in catalysis. L27 is also not required for peptidyl-tRNA hydrolysis during termination. The primary functional role of L27 appears to be in subunit association rather than in the core mechanism of peptide bond formation. Rapid kinetics (stopped-flow), translation assays with natural mRNAs, pH-dependence measurements, L27 deletion strain RNA (New York, N.Y.) High 26475831
2001 A. aeolicus L27 expressed in an E. coli L27-deletion mutant is incorporated into completed E. coli ribosomes and can partially restore growth rate and ribosomal function, but unlike E. coli L27, fails to promote 50S subunit assembly, demonstrating a separable role for L27 in ribosome assembly versus translation. Heterologous complementation of L27 deletion mutant, growth rate assays, ribosome sedimentation analysis, CD and NMR spectroscopy Journal of bacteriology Medium 11673426
2014 In Staphylococcus aureus and other Firmicutes, ribosomal protein L27 is encoded with an N-terminal extension absent from mature ribosomes. A conserved cysteine protease (Prp) performs post-translational N-terminal cleavage of L27. This processing is required for normal ribosomal function, as the extension is absent from mature ribosomes. Proteomics identification, biochemical characterization of Prp protease activity, sequence analysis of mature L27 vs precursor Molecular microbiology Medium 25388641
2025 In S. pneumoniae, the Prp protease forms dimers that efficiently cleave ribosomal protein L27 in vitro at a specific N-terminal site. An inactive Prp variant (PrpC34S) binds L27 without cleaving it, and an L27 F12A mutation abolishes Prp binding, defining the cleavage site and protease-substrate interaction. Overexpression of PrpC34S in vivo is detrimental to S. pneumoniae growth. A Δprp strain is viable (unlike in S. aureus) because another protease can cleave L27, but a strain lacking the N-terminal extension shows impaired growth. In vitro cleavage assays, site-directed mutagenesis (PrpC34S, L27 F12A), in vivo overexpression, Δprp knockout, growth assays bioRxiv : the preprint server for biologypreprint Medium 40766419
2014 Loss-of-function mutations in RPL27 (including a de novo splicing error mutation) cause Diamond-Blackfan anaemia. In vitro knockdown of RPL27 disturbs pre-ribosomal RNA processing. Zebrafish models of rpl27 mutation show impairments of erythrocyte production and developmental defects (tail and/or brain), establishing RPL27 as required for pre-rRNA processing and erythropoiesis. Whole-exome sequencing, in vitro siRNA knockdown with pre-rRNA processing analysis, zebrafish morpholino/mutant model with erythroid and developmental phenotype readouts British journal of haematology High 25424902
2023 siRNA-mediated silencing of RPL27 in human colorectal cancer cell lines (HCT116, HT29) suppresses cell proliferation, arrests cell cycle, and induces apoptosis in vitro and inhibits xenograft growth in vivo. RPL27 silencing downregulates PLK1 protein and G2/M regulators (phospho-CDC25C, CDK1, cyclin B1), and reduces sphere-forming capacity of CD133+ cancer stem cells with concurrent decreases in CD133 and PLK1, placing RPL27 upstream of PLK1 in a signaling axis controlling CRC proliferation and stemness. siRNA knockdown, CCK8/colony assays, FACS, xenograft mouse model, RNA sequencing, western blotting, sphere-forming assays International journal of oncology Medium 37387446
1989 Mouse ribosomal protein L27' (homolog of human RPL27) can functionally substitute for yeast ribosomal protein L29 in yeast ribosomes when yeast L29 is absent, supporting viability and normal growth. However, when both yeast L29 and mouse L27' are present, yeast L29 is preferentially assembled, demonstrating that the mammalian protein is structurally and functionally compatible with the eukaryotic ribosome core. Heterologous complementation in yeast (L29 deletion strain), cycloheximide resistance assay, growth assays Proceedings of the National Academy of Sciences of the United States of America Medium 2643099

Source papers

Stage 0 corpus · 54 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2004 Quaternary structure, protein dynamics, and synaptic function of SAP97 controlled by L27 domain interactions. Neuron 206 15504326
2014 Loss of function mutations in RPL27 and RPS27 identified by whole-exome sequencing in Diamond-Blackfan anaemia. British journal of haematology 84 25424902
2005 A protein component at the heart of an RNA machine: the importance of protein l27 for the function of the bacterial ribosome. Molecular cell 80 16285924
1981 The use of 2-iminothiolane as an RNA-protein cross-linking agent in Escherichia coli ribosomes, and the localisation on 23S RNA of sites cross-linked to proteins L4, L6, L21, L23, L27 and L29. Nucleic acids research 72 6170935
2004 The tetrameric L27 domain complex as an organization platform for supramolecular assemblies. Nature structural & molecular biology 70 15048107
1976 Isolation of eukaryotic ribosomal proteins. Purification and characterization of the 60 S ribosomal subunit proteins L4, L5, L7, L9, L11, L12, L13, L21, L22, L23, L26, L27, L30, L33, L35', L37, and L39. The Journal of biological chemistry 70 1002715
2001 Enhanced expression of S8, L12, L23a, L27 and L30 ribosomal protein mRNAs in human hepatocellular carcinoma. Anticancer research 69 11724303
1977 Isolation of eukaryotic ribosomal proteins. Purification and characterization of 60 S ribosomal subunit proteins L3, L6, L7', L8, L10, L15, L17, L18, L19, L23', L25, L27', L28, L29, L31, L32, L34, L35, L36, L36', and L37'. The Journal of biological chemistry 68 863909
1988 RNA-protein cross-linking in Escherichia coli 50S ribosomal subunits; determination of sites on 23S RNA that are cross-linked to proteins L2, L4, L24 and L27 by treatment with 2-iminothiolane. Nucleic acids research 66 3278299
1998 Ribosomal protein L27 participates in both 50 S subunit assembly and the peptidyl transferase reaction. The Journal of biological chemistry 59 9677420
2008 Role of ribosomal protein L27 in peptidyl transfer. Biochemistry 37 18393533
2010 Central regulation of locomotor behavior of Drosophila melanogaster depends on a CASK isoform containing CaMK-like and L27 domains. Genetics 35 21059886
2004 Structural basis for L27 domain-mediated assembly of signaling and cell polarity complexes. The EMBO journal 34 15241471
2018 Purification and characterization of ribosomal proteins L27 and L30 having antimicrobial activity produced by the Lactobacillus salivarius SGL 03. Journal of applied microbiology 33 29159916
2005 A unified assembly mode revealed by the structures of tetrameric L27 domain complexes formed by mLin-2/mLin-7 and Patj/Pals1 scaffold proteins. Proceedings of the National Academy of Sciences of the United States of America 25 15863617
2002 Coordinated folding and association of the LIN-2, -7 (L27) domain. An obligate heterodimerization involved in assembly of signaling and cell polarity complexes. The Journal of biological chemistry 25 12110687
2007 Lin-7 targets the Kir 2.3 channel on the basolateral membrane via a L27 domain interaction with CASK. American journal of physiology. Cell physiology 24 17913842
1991 Ribosomal protein L27 is identical in chick and rat. Nucleic acids research 22 1709488
1979 Genes coding for ribosomal proteins S15, L21, and L27 map near argG in Escherichia coli. Journal of bacteriology 22 378941
2014 Specific N-terminal cleavage of ribosomal protein L27 in Staphylococcus aureus and related bacteria. Molecular microbiology 21 25388641
1994 Phorbol ester induction of differentiation and apoptosis in the K562 cell line is accompanied by marked decreases in the stability of globin mRNAs and decreases in the steady state level of mRNAs encoding for ribosomal proteins L35, L31, L27, and L21. Cellular & molecular biology research 20 7804323
1989 Functional substitution of mouse ribosomal protein L27' for yeast ribosomal protein L29 in yeast ribosomes. Proceedings of the National Academy of Sciences of the United States of America 19 2643099
1988 Nucleotide sequence of cloned cDNA specific for rat ribosomal protein L27. European journal of biochemistry 17 2833393
1980 Purification of Drosophila ribosomal proteins. Isolation of proteins S8, S13, S14, S16, S19, S20/L24, S22/L26, S24, S25/S27, S26, S29, L4, L10/L11, L12, L13, L16, L18, L19, L27, 1, 7/8, 9, and 11. Biochemistry 16 6773542
2015 Activities of the peptidyl transferase center of ribosomes lacking protein L27. RNA (New York, N.Y.) 15 26475831
2012 Structure of an L27 domain heterotrimer from cell polarity complex Patj/Pals1/Mals2 reveals mutually independent L27 domain assembly mode. The Journal of biological chemistry 15 22337881
2002 Simultaneous horizontal gene transfer of a gene coding for ribosomal protein l27 and operational genes in Arthrobacter sp. Journal of molecular evolution 15 12486522
1994 Cloning and nucleotide sequence of a full length cDNA encoding ribosomal protein L27 from human fetal kidney. Biochimica et biophysica acta 14 8148381
2023 RPL27 contributes to colorectal cancer proliferation and stemness via PLK1 signaling. International journal of oncology 13 37387446
2006 Promoter shuffling at a nuclear gene for mitochondrial RPL27. Involvement of interchromosome and subsequent intrachromosome recombinations. Plant physiology 11 16603668
2010 Structural basis for tandem L27 domain-mediated polymerization. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 10 20702775
1993 Cloning and nucleotide sequencing of the genes, rpIU and rpmA, for ribosomal proteins L21 and L27 of Escherichia coli. DNA sequence : the journal of DNA sequencing and mapping 10 8312607
2012 Role of the ribosomal protein L27 revealed by single-molecule FRET study. Protein science : a publication of the Protein Society 9 22930421
2004 Crystal structure of ribosomal protein L27 from Thermus thermophilus HB8. Protein science : a publication of the Protein Society 9 15340170
1987 Localization of ribosomal protein L27 at the peptidyl transferase centre of the 50 S subunit, as determined by immuno-electron microscopy. Molecular & general genetics : MGG 8 3123891
1988 Expression of naturally occurring RNA molecules complementary to the murine L27' ribosomal protein mRNA. Gene 7 2468568
2020 Identification and characterization of SaRpAMP, a 60S ribosomal protein L27-derived antimicrobial peptide from amur catfish, Silurus asotus. Fish & shellfish immunology 6 32711152
2018 Structures of the L27 Domain of Disc Large Homologue 1 Protein Illustrate a Self-Assembly Module. Biochemistry 6 29261291
2016 Coexpression of Escherichia coli obgE, Encoding the Evolutionarily Conserved Obg GTPase, with Ribosomal Proteins L21 and L27. Journal of bacteriology 6 27137500
2024 Identification of a novel antimicrobial peptide from amphioxus ribosomal protein L27. Fish & shellfish immunology 5 39622458
2014 Characterization and site-directed mutagenesis of a novel class II 5-enopyruvylshikimate-3-phosphate (EPSP) synthase from the deep-sea bacterium Alcanivorax sp. L27. Enzyme and microbial technology 5 25039062
2001 Differential effects of replacing Escherichia coli ribosomal protein L27 with its homologue from Aquifex aeolicus. Journal of bacteriology 5 11673426
2003 Trypanosoma cruzi: identification and characterization of a novel ribosomal protein L27 (TcrL27) that cross-reacts with an affinity-purified anti-Sm antibody. Parasitology 4 12866796
2024 The L27 domain of MPP7 enhances TAZ-YY1 cooperation to renew muscle stem cells. EMBO reports 3 39496834
2023 Effect of RPL27 knockdown on the proliferation and apoptosis of human liver cancer cells. Biochemical and biophysical research communications 3 37812860
2004 Ac His1 [D-Phe2, K15, R16, L27] VIP (3-7)/GRF (8-27)--a VPAC1 receptor antagonist--is an inverse agonist on two constitutively active truncated VPAC1 receptors. Peptides 3 15501526
2024 Identification of Genes Associated with Familial Focal Segmental Glomerulosclerosis Through Transcriptomics and In Silico Analysis, Including RPL27, TUBB6, and PFDN5. International journal of molecular sciences 1 39519211
2011 Crystallization and preliminary X-ray data collection of the L27(PATJ)-(L27N,L27C)(Pals1)-L27(MALS) tripartite complex. Acta crystallographica. Section F, Structural biology and crystallization communications 1 22102253
1994 The gene for ribosomal protein L27 is located on the plastid rather than the nuclear genome of the chlorophyll c-containing alga Pleurochrysis carterae. Plant molecular biology 1 8111025
2025 Cleavage of Streptococcus pneumoniae ribosomal protein L27 by the Prp protease. bioRxiv : the preprint server for biology 0 40766419
2025 Ribosomal protein L27 contributes to virulence and maduramicin resistance in Eimeria tenella. International journal for parasitology. Drugs and drug resistance 0 41004933
2024 De Novo Variant in the RPL27 Gene in a Second Infant with Diamond-Blackfan Anemia. Case reports in hematology 0 38988374
2023 The L27 Domain of MPP7 enhances TAZ-YY1 Cooperation to Renew Muscle Stem Cells. bioRxiv : the preprint server for biology 0 37961392
2023 The L27 Domain of MPP7 enhances TAZ-YY1 Cooperation to Renew Muscle Stem Cells. Research square 0 38077061

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